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https://www.readbyqxmd.com/read/29134743/rapid-determination-of-ginkgolic-acids-in-ginkgo-biloba-kernels-and-leaves-by-direct-analysis-in-real-time-mass-spectrometry
#1
Zhongping Huang, Yueting Xu, Yilei Huang, Charles Liu, Kezhi Jiang, Lili Wang
A novel method on basis of direct analysis in real time integrated with mass spectrometry was established and applied into rapid determination of ginkgolic acids in Ginkgo biloba kernels and leaves. Instrument parameter settings were optimized to obtain the sensitive and accurate determination of ginkgolic acids. At the sample introduction speed of 0.2 mm/s, high intensity of [M-H](-) ions for ginkgolic acids were observed in the negative ion mode by utilization of high purity helium gas at 450°C. 2 μL methanol extract of Ginkgo biloba kernels or leaves dropped on the surface of Quick-Strip module was analyzed after solvent evaporated to dryness...
November 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29127795/an-investigation-of-the-leaf-retention-capacity-efficiency-and-mechanism-for-atmospheric-particulate-matter-of-five-greening-tree-species-in-beijing-china
#2
Jinqiang Liu, Zhiguo Cao, Songyan Zou, Huanhuan Liu, Xiao Hai, Shihua Wang, Jie Duan, Benye Xi, Guangxuan Yan, Shaowei Zhang, Zhongkui Jia
Urban trees have the potential to reduce air pollution, but the retention capacity and efficiency of different tree species for atmospheric particulate matter (PM) accumulation and the underlying mechanism hasn't been well understood. To select tree species with high air purification abilities, the supplementing ultrasonic cleaning (UC) procedure was first introduced into the conventional leaf cleaning methods [single water cleaning (WC) or plus brush cleaning (BC)] for eluting the leaf-retained PM. Further updates to the methodology were applied to investigate the retention capacity, efficiency, and mechanism for PM of five typical greening tree species in Beijing, China...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29121568/a-metabolic-exposure-oriented-network-regulation-strategy-for-the-identification-of-effective-combination-in-the-extract-of-ginkgo-biloba-l
#3
Xin-Guang Liu, Cai-Yi Cheng, Ji-Xin Wang, Hong Luo, Li-Fan Tu, Lin Lin, Bin Wu, Hui-Ying Wang, Ke Liu, Ping Li, Hua Yang
Nowadays, network pharmacology-based methods were increasing proposed to screen synergistic or combinatorial compounds from herbal medicines (HMs), while these researches mainly focused on structural prediction or experiment-based interaction between single compound and target protein. The proportion of each chemical in the nature and their metabolic process was ignored, which might decide an optimized composition for their synergistic effect. To exact the effective combination of HMs, a metabolic distribution-oriented network regulation strategy was developed for the identification of effective combination...
November 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29098842/-drug-combination-characteristics-of-shenxiong-glucose-injection-in-treating-ischemic-cerebrovascular-disease-in-real-world
#4
Gui-Qian Wang, Yan-Ming Xie, Huan Liu, Yin Zhang, Ping-Ping Jia, Yan Zhuang
To analyze the clinical drug use characteristics of Shenxiong glucose injection in the treatment of ischemic cerebrovascular disease. From hospital information system (HIS) of 19 hospitals over China, the basic information of patients with Shenxiong glucose injection for ischemic cerebrovascular disease, traditional Chinese medicine and Western medicine diagnosis information, order information, and laboratory examination information were extracted. Then Apriori algorithm was used to construct the model, and the association analysis was performed by using Clementine 12 to analyze the clinical drug use characteristics of Shenxiong glucose injection in the real world...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29058254/neuroprotective-effects-of-ginkgo-biloba-extract-and-ginkgolide-b-against-oxygen-glucose-deprivation-reoxygenation-and-glucose-injury-in-a-new-in-vitro-multicellular-network-model
#5
Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of Ginkgo biloba extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel in vitro rat cortical capillary endothelial cellastrocyte- neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen-glucose deprivation/reoxygenation and glucose (OGD/R) injury...
October 2, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29054095/ginkgolide-b-and-bilobalide-ameliorate-neural-cell-apoptosis-in-%C3%AE-synuclein-aggregates
#6
Jun Hua, Nuo Yin, Beibei Yang, Ji Zhang, Jianhua Ding, Yi Fan, Gang Hu
The accumulation of aggregated forms of the α-Synuclein (α-Syn) is associated with the pathogenesis of Parkinson's disease (PD), a chronic progressive neurodegenerative disorder. Extensive evidences have shown the promising effects of Ginkgo biloba consumption on motor activity after PD. However, the mechanisms underline the α-Syn-induced cell damage and whether ginkgolides exert neuroprotection against this injury are unclear. Here we showed that aggregated recombinant human α-Syn, but not α-Syn monomers, triggered cell injury in cultured human neuroblastoma cell line SH-SY5Y in an apoptosis way by using flow cytometry and western blot assay...
October 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29047177/selected-hepatoprotective-herbal-medicines-evidence-from-ethnomedicinal-applications-animal-models-and-possible-mechanism-of-actions
#7
REVIEW
Muhammad Ali, Tariq Khan, Kaneez Fatima, Qurat Ul Ain Ali, Muhammad Ovais, Ali Talha Khalil, Ikram Ullah, Abida Raza, Zabta Khan Shinwari, Muhammad Idrees
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044313/evaluation-of-the-anti-osteoporotic-effect-of-ginkgo-biloba-l-in-wistar-rats-with-glucocorticoid-induced-osteoporosis-by-bone-densitometry-using-dual-energy-x-ray-absorptiometry-dexa-and-mechanical-testing
#8
Leda M F Lucinda, Beatriz J V Aarestrup, Maycon M Reboredo, Thais D A Pains, Raphael Z Chaves, João E P Reis, Mário J Q Louzada, Martha O Guerra
Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29042071/influence-of-ginkgo-biloba-extract-egb-761-on-expression-of-il-1-beta-il-6-tnf-alfa-hsp-70-hsf-1-and-cox-2-after-noise-exposure-in-the-rat-cochlea
#9
Remzi Dogan, Alev Pektas Sjostrand, Alper Yenıgun, Ersin Karatas, Abdurrahim Kocyigit, Orhan Ozturan
OBJECTIVE: The objective of this study was to investigate the influence of Ginkgo Biloba in early treatment of noise induced hearing loss on expression of IL-6, IL-1 Beta, TNF-alfa, HSP-70, HSF-1 and COX-2 in the rat cochlea. METHODS: Thirty two female rats were randomly divided into four groups (Acoustic Trauma, Ginkgo Biloba, Acoustic Trauma+Ginkgo Biloba, Non Treatment). Auditory brainstem response (ABR) was applied in all the groups. At the end of the study, IL-1Beta, IL-6, TNF-alpha, HSP-70, HSF-1 and COX-2 were studied in cochlear tissue with ELISA and Western blot analysis...
October 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29032664/the-protective-effect-of-egb-761-against-3-nitropropionic-acid-induced-hearing-loss-the-role-of-sirtuin-1
#10
Mun Young Chang, Jihye Rhee, Shin Hye Kim, Young Ho Kim
Objectives: Local administration of 3-nitropropionic acid (3-NP) to the inner ear induces sensorineural hearing loss. Several studies have shown the otoprotective effects of ginkgo biloba extract EGb 761. Moreover, EGb 761 has been reported to activate Sirtuin 1 (SIRT1). The present study was designed to investigate whether EGb 761 prevents 3-NPinduced sensorineural hearing loss and determine its effects on the expression of SIRT1. Methods: Sprague Dawley rats were divided into four experimental groups: control group receiving vehicle of 3-NP, EGb group receiving EGb 761, 3-NP group receiving 3-NP, and EGb+3-NP group receiving EGb 761 and 3-NP...
October 17, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29032040/effects-of-dietary-ginkgo-biloba-leaf-extract-on-growth-performance-plasma-biochemical-parameters-fish-composition-immune-responses-liver-histology-and-immune-and-apoptosis-related-genes-expression-of-hybrid-grouper-epinephelus-lanceolatus%C3%A2-%C3%A3-epinephelus-fuscoguttatus%C3%A2
#11
Xiaohong Tan, Zhenzhu Sun, Qingying Liu, Huaqun Ye, Cuiyun Zou, Chaoxia Ye, Anli Wang, Heizhao Lin
For thousands of years, leaves from the Ginkgo biloba tree have been a common treatment in Chinese medicine. The present study was conducted to investigate the effects of dietary ginkgo biloba leaf extract (GBE) supplementation on growth performance, plasma biochemical parameters, fish composition, immune responses, liver histology, and immune and apoptosis-related genes expression of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀) fed high lipid diets. A basal diet supplemented with GBE at 0, 0...
October 11, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29027416/-application-of-quality-by-design-in-granulation-process-for-ginkgo-leaf-tablet-%C3%A2-%C3%AF-influence-and-control-of-raw-materials-quality-variation
#12
Xiang-Long Cui, Bing Xu, Jun-Wen Liu, Guo-Lin Shi, Xin-Yuan Shi, Yan-Jiang Qiao
Raw materials' quality variation could affect the quality consistency of product and the clinical efficacy. In this paper, the high shear wet granulation (HSWG) process of the ginkgo leaf tablet was taken as the research object. Ginkgo biloba extracts and excipients microcrystalline cellulose collected from various sources and batches were used to simulate raw materials' quality variation. Real-time torque was recorded to analyze the viscosity of the wetting mass, and then by combining with physical fingerprint, the impact of physical quality variation of powders on granule properties could be investigated...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027414/-application-of-quality-by-design-in-granulation-process-for-ginkgo-leaf-tablet-%C3%A2-%C3%AF-identification-of-critical-quality-attributes
#13
Bing Xu, Xiang-Long Cui, Chan Yang, Xin Wang, Xin-Yuan Shi, Yan-Jiang Qiao
Quality by design (QbD) highlights the concept of "begin with the end", which means to thoroughly understand the target product quality first, and then guide pharmaceutical process development and quality control throughout the whole manufacturing process. In this paper, the Ginkgo biloba granules intermediates were taken as the research object, and the requirements of the tensile strength of tablets were treated as the goals to establish the methods for identification of granules' critical quality attributes (CQAs) and establishment of CQAs' limits...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027413/-application-of-quality-by-design-in-granulation-process-for-ginkgo-leaf-tablet-%C3%A2-%C3%AF-comprehensive-characterization-of-granule-properties
#14
Xiang-Long Cui, Bing Xu, Yi Zhang, Na Zhang, Xin-Yuan Shi, Yan-Jiang Qiao
In this paper, the granules intermediate prepared from the wet granulation process of ginkgo leaf tablet were taken as the research object, and then the stackability, homogeneity, flowability, compressibility and stability of granules were characterized by using micromeritics evaluation method. The physical fingerprint of granules were constructed by 16 indexes including bulk density, tapped density, span, width, relative homogeneity index, aspect ratio, Hausner ratio, angle of repose, granule flow time, inter-particle porosity, Carr index, specific surface area, pore volume, pore size distribution, loss on drying and hygroscopicity...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29023415/characterization-function-and-transcriptional-profiling-analysis-of-3-hydroxy-3-methylglutaryl-coa-synthase-gene-gbhmgs1-towards-stresses-and-exogenous-hormone-treatments-in-ginkgo-biloba
#15
Xiangxiang Meng, Qiling Song, Jiabao Ye, Lanlan Wang, Feng Xu
3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is one of the rate-limiting enzymes in the mevalonate pathway as it catalyzes the condensation of acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA. In this study, A HMGS gene (designated as GbHMGS1) was cloned from Ginkgo biloba for the first time. GbHMGS1 contained a 1422-bp open-reading frame encoding 474 amino acids. Comparative and bioinformatics analysis revealed that GbHMGS1 was extensively homologous to HMGSs from other plant species. Phylogenetic analysis indicated that the GbHMGS1 belonged to the plant HMGS superfamily, sharing a common evolutionary ancestor with other HMGSs, and had a further relationship with other gymnosperm species...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28994537/-simultaneous-determination-of-eleven-components-in-ginkgo-biloba-leaves-by-high-performance-liquid-chromatography-method
#16
Jin-Li Lv, Biao Yang, Meng-Xuan Li, Zhao-Qing Meng, Shi-Ping Ma, Zhen-Zhong Wang, Gang Ding, Wen-Zhe Huang, Wei Xiao
To study Ginkgo biloba leaves in different producing area, we establish an HPLC method for the simultaneously determination of seven flavonoids glycosides and four biflavonoids in G. biloba leaves. The analysis was performed on an Agilent ZORBAX SB-C₁₈ column(4.6 mm×250 mm, 5 μm) wich acetonitrile, and 0.4% phosphoric acid as mobile phase at flow rate of 1 mL•min⁻¹ in a gradient edution, and the detection was carried out at 254 nm.The calibration curves of the seven flavonoids glycosides and four biflavonoids had a good linearitiy with good recoveries...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28993980/characterization-cytotoxicity-and-genotoxicity-of-tio2-and-folate-coupled-chitosan-nanoparticles-loading-polyprenol-based-nanoemulsion
#17
Ran Tao, Chengzhang Wang, Changwei Zhang, WenJun Li, Hao Zhou, Hongxia Chen, Jianzhong Ye
The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving polyprenol in nanoemulsion of sodium tripolyphosphate (TPP)/TiO2 solution, Triton X-100, and 1-octanol by inversed-phase emulsification (EIP) and ultrasonic emulsification (UE) method. Folic acid (FA)-coupled chitosan (CS) nanoparticles (NPs), GBP-FA-CS-NPs and GBP-TiO2-FA-CS-NPs, were fabricated by ionic cross-linking of positively charged FA-CS conjugates and negatively charged nanoemulsion with TPP/TiO2...
October 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28980599/-the-influence-of-memoplant-monotherapy-on-the-dizziness
#18
A I Kryukov, N L Kunel'skaya, E S Yanyushkina, E V Baybakova, M A Chugunova, M V Tardov, Z O Zaoeva, G N Izotova
The objective of the present work was to study the influence of the dry extract from the leaves of Ginkgo biloba EGb 761 (used as monotherapy at a dose of 120 mg twice daily during 4 months) on the vestibular function of the patients presenting with cochleovestibular pathology of peripheral and mixed genesis. We present the results obtained by the objective and subjective methods for the evaluation of the vestibular function as well as the neurological and psychoemotional state of the 40 patients that was carried out during the four months of memoplant monotherapy...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28973764/in-vivo-antimutagenic-activity-of-the-medicinal-plants-pfaffia-glomerata-brazilian-ginseng-and-ginkgo-biloba
#19
I V Almeida, E Düsman, G I Mattge, F Toledo, A F Reusing, V E P Vicentini
Complementary and alternative therapies, including the use of medicinal plants, have become almost standard among the world's population. Pfaffia glomerata (PG), popularly known as Brazilian ginseng, is widely used as a restorer of vital functions, increasing mental balance, and is used for the treatment of diabetes and rheumatism. Ginkgo biloba (GB) is one of the oldest known gymnosperms, whose leaves are widely used for its potentiating action on the nervous system. The biological activities of these plants were determined on bone marrow cells of Wistar rats treated in vivo...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28966643/extract-of-ginkgo-biloba-promotes-neuronal-regeneration-in-the-hippocampus-after-exposure-to-acrylamide
#20
Wei-Ling Huang, Yu-Xin Ma, Yu-Bao Fan, Sheng-Min Lai, Hong-Qing Liu, Jing Liu, Li Luo, Guo-Ying Li, Su-Min Tian
Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba. To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus...
August 2017: Neural Regeneration Research
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