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Ginkgo biloba

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https://www.readbyqxmd.com/read/28642670/ginkgo-biloba-improves-bone-formation-during-fracture-healing-an-experimental-study-in-rats
#1
Nizamettin Guzel, Emrah Sayit, Osman Aynaci, Servet Kerimoglu, Esin Yulug, Murat Topbas
OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28639555/ginkgo-biloba-and-lycopene-are-effective-on-cisplatin-induced-ototoxicity
#2
Erkan Esen, Fatih Özdoğan, Seren Gülşen Gürgen, Halil Erdem Özel, Serdar Başer, Selahattin Genç, Adin Selçuk
OBJECTIVE: The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS AND METHODS: Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2 ; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into four groups. Group 1 (n=8) was defined as the healthy control group. Cisplatin was given intraperitoneally as single dose of 12 mg/kg to group 2 (n=8), group 3 (n=8), and group 4 (n=8)...
June 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28622621/development-of-an-ultra-fast-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-determination-of-seven-flavonoids-in-rat-plasma-application-to-a-comparative-pharmacokinetic-investigation-of-ginkgo-biloba-extract-and-single-pure-ginkgo-flavonoids
#3
Tianyang Wang, Jie Xiao, Huiping Hou, Pei Li, Ziyue Yuan, Huarong Xu, Ran Liu, Qing Li, Kaishun Bi
For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C18 chromatographic column (100mm×2...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28616659/isolation-and-functional-characterization-of-a-circadian-regulated-constans-homolog-gbco-from-ginkgo-biloba
#4
Jiaping Yan, Dun Mao, Xiaomeng Liu, Lanlan Wang, Feng Xu, Guiyuan Wang, Weiwei Zhang, Yongling Liao
This is the first report to clone and functionally characterize a flowering time gene GbCO in perennial gymnosperm Ginkgo biloba. GbCO complements the co mutant of Arabidopsis, restoring normal early flowering. CONSTANS (CO) is a central regulator of photoperiod pathway, which channels inputs from light, day length, and circadian clock to promote the floral transition. In order to understand the role of CO in gymnosperm Ginkgo biloba, which has a long juvenile phase (15-20 years), a CO homolog (GbCO) was isolated and characterized from G...
June 14, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28603534/combining-metabolic-profiling-and-gene-expression-analysis-to-reveal-the-biosynthesis-site-and-transport-of-ginkgolides-in-ginkgo-biloba-l
#5
Xu Lu, Hua Yang, Xinguang Liu, Qian Shen, Ning Wang, Lian-Wen Qi, Ping Li
The most unique components of Ginkgo biloba extracts are terpene trilactones (TTLs) including ginkgolides and bilobalide. Study of TTLs biosynthesis has been stagnant in recent years. Metabolic profiling of 40 compounds, including TTLs, flavonoids, and phenolic acids, were globally analyzed in leaf, fibrous root, main root, old stem and young stem extracts of G. biloba. Most of the flavonoids were mainly distributed in the leaf and old stem. Most of phenolic acids were generally distributed among various tissues...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28591721/ginkgolide-k-attenuates-neuronal-injury-after-ischemic-stroke-by-inhibiting-mitochondrial-fission-and-gsk-3%C3%AE-dependent-increases-in-mitochondrial-membrane-permeability
#6
Xu Zhou, Hui-Ying Wang, Bin Wu, Cai-Yi Cheng, Wei Xiao, Zhen-Zhong Wang, Yu-Yu Yang, Ping Li, Hua Yang
Ginkgolide K (GK) belongs to the ginkgolide family of natural compounds found in Ginkgo biloba leaves, which have been used for centuries to treat cerebrovascular and cardiovascular diseases. We evaluated the protective effects of GK against neuronal apoptosis by assessing its ability to sustain mitochondrial integrity and function. Co-immunoprecipitation showed that Drp1 binding to GSK-3β was increased after an oxygen-glucose deprivation/reperfusion (OGD/R) insult in cultured neuroblastoma cells. This induced Drp1 and GSK-3β translocation to mitochondria and mitochondrial dysfunction, which was attenuated by GK...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28558873/mechanism-for-ginkgolic-acid-15-1-induced-mdck-cell-necrosis-mitochondria-and-lysosomes-damages-and-cell-cycle-arrest
#7
Qing-Qing Yao, Zhen-Hua Liu, Ming-Cheng Xu, Hai-Hong Hu, Hui Zhou, Hui-Di Jiang, Lu-Shan Yu, Su Zeng
Ginkgolic acids (GAs), primarily found in the leaves, nuts, and testa of ginkgo biloba, have been identified with suspected allergenic, genotoxic and cytotoxic properties. However, little information is available about GAs toxicity in kidneys and the underlying mechanism has not been thoroughly elucidated so far. Instead of GAs extract, the renal cytotoxicity of GA (15 : 1), which was isolated from the testa of Ginkgo biloba, was assessed in vitro by using MDCK cells. The action of GA (15 : 1) on cell viability was evaluated by the MTT and neutral red uptake assays...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28553632/hydroquinone-a-novel-bioactive-compound-from-plant-derived-smoke-can-cue-seed-germination-of-lettuce
#8
Muhammad Kamran, Abdul L Khan, Liaqat Ali, Javid Hussain, Muhammad Waqas, Ahmed Al-Harrasi, Qari M Imran, Yoon-Ha Kim, Sang-Mo Kang, Byung-Wook Yun, In-Jung Lee
Plant-derived smoke has been known to play an important role in distribution and growth of vegetation. Using a proficiently designed furnace, we extracted smoke from the leaves of four plant viz. Helianthus annuus,Aloe vera,Ginkgo biloba, and Cymbopogon jwarancusa. Smoke dilutions obtained from these plants were obtained in different concentrations to identify potential lettuce growth promoting smoke solution. Results revealed that smoke obtained from G. biloba significantly enhanced the lettuce seed germination...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28553225/cardioprotective-action-of-ginkgo-biloba-extract-against-sustained-%C3%AE-adrenergic-stimulation-occurs-via-activation-of-m2-no-pathway
#9
Thássio R R Mesquita, Itamar C G de Jesus, Jucilene F Dos Santos, Grace K M de Almeida, Carla M L de Vasconcelos, Silvia Guatimosim, Fabrício N Macedo, Robervan V Dos Santos, José E R de Menezes-Filho, Rodrigo Miguel-Dos-Santos, Paulo T D Matos, Sérgio Scalzo, Valter J Santana-Filho, Ricardo L C Albuquerque-Júnior, Rose N Pereira-Filho, Sandra Lauton-Santos
Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of several human disorders. However, the mechanisms involved in the protective actions of Ginkgo biloba on cardiovascular diseases remain poorly elucidated. Taking into account recent studies showing beneficial actions of cholinergic signaling in the heart and the cholinergic hypothesis of Ginkgo biloba-mediated neuroprotection, we aimed to investigate whether Ginkgo biloba extract (GBE) promotes cardioprotection via activation of cholinergic signaling in a model of isoproterenol-induced cardiac hypertrophy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28454337/inhibitory-effect-of-ginkgol-c17-1-on-the-biological-behavior-of-tumor-cells
#10
Yueying Li, Jun Liu, Yali Liu, Xiaoming Yang, Bingzhong Huang, Min Chen
Ginkgol C17:1 is a bioactive compound derived from Ginkgo biloba. In the present study, the effect and possible mechanisms of action of Ginkgol C17:1 on the biological behaviors of tumor cells were investigated. Whilst cell proliferation was assessed using the MTT assay, the behaviors of cell migration and invasion were explored using Transwell and modified Transwell assays. The results revealed that Ginkgol C17:1 significantly inhibited the proliferation, migration and invasion of human tumor cells in a dose-dependent manner...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28449688/yy-1224-a-terpene-trilactone-strengthened-ginkgo-biloba-attenuates-neurodegenerative-changes-induced-by-%C3%AE-amyloid-1-42-or-double-transgenic-overexpression-of-app-and-ps1-via-inhibition-of-cyclooxygenase-2
#11
Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima, Hyoung-Chun Kim
BACKGROUND: Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened extract of G. biloba, showed anti-inflammatory, neurotrophic, and antioxidant effects. RESULTS: We investigated the pharmacological potential of YY-1224 in β-amyloid (Aβ) (1-42)-induced memory impairment using cyclooxygenase-2 (COX-2) knockout (-/-) and APPswe/PS1dE9 transgenic (APP/PS1 Tg) mice...
April 27, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28449063/extraction-and-determination-of-quercetin-from-ginkgo-biloba-by-dess-based-polymer-monolithic-cartridge
#12
Xiaoqin Wang, Guizhen Li, Kyung Ho Row
Deep eutectic solvents (DES) were formed from choline chloride (ChCl). DES-modified polymer monolithic (DES-M), template molecular polymer monolithic and non-DES-M without a molecular template were synthesized in identical process. These polymer materials were characterized by field emission scanning electron microscopy and Fourier transform infrared spectroscopy. The significant selective adsorption properties of the polymers were assessed by an absorption capacity experiment and solid-phase extraction (SPE)...
April 26, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28444385/the-effects-of-bacillus-coagulans-fermented-and-non-fermented-ginkgo-biloba-on-abdominal-fat-deposition-and-meat-quality-of-peking-duck
#13
Xiaoyan Liu, Guanjun Cao, Jinglong Zhou, Xuan Yao, Binghu Fang
No abstract text is available yet for this article.
May 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28416372/effects-of-bilobalide-ginkgolide-b-and-picrotoxinin-on-gabaa-receptor-modulation-by-structurally-diverse-positive-modulators
#14
Chiu Chin Ng, Rujee K Duke, Tina Hinton, Graham A R Johnston
Anxiolytics and anticonvulsants generally positively modulate the action of GABA, whereas many convulsants (including the chloride channel blocker picrotoxinin) negatively modulate the action of GABA on GABAA receptors. Like picrotoxinin, bilobalide and ginkgolide B, active constituents of Ginkgo biloba, have been shown to negatively modulate the action of GABA at α1β2γ2L GABAA receptors. However, unlike picrotoxinin, bilobalide and ginkgolide B are not known to cause convulsions. We have assessed the action of bilobalide, ginkgolide B and picrotoxinin on a range of GABAA modulators (etomidate, loreclezole, propofol, thiopentone sodium, diazepam, and allopregnanolone), using two-electrode voltage clamp electrophysiology at recombinant α1β2γ2L GABAA receptors expressed in Xenopus oocytes...
April 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28416145/the-ginkgo-biloba-extract-gbe-protects-the-kidney-from-damage-produced-by-a-single-and-low-dose-of-carbon-tetrachloride-in-adult-male-rats
#15
R M Chávez-Morales, F Jaramillo-Juárez, M L Rodríguez-Vázquez, M C Martínez-Saldaña, F A Posadas Del Río, J A Garfias-López
Gingko biloba leaves have been used as herbal medicine in China for 5000 years, and the standardized leaf extract (GB-STE) has some beneficial effects in the treatment of age-related, cardiovascular, and neurological diseases. The aim of this study was to investigate the renoprotective effects of the Gingko biloba extract (GbE) against the toxicity of a single and relatively low dose of carbon tetrachloride (CCl4). In male adult Wistar rats, we determined the urine flux, the concentration of total proteins in urine, the concentration of glucose in urine, and the concentration of malondialdehyde (MDA) in renal cortex as well as two markers of renal function (clearance of inulin and p-aminohippurate); we also compared the histological lesions caused by CCl4...
April 13, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28403270/evidence-for-anti-aging-south-korean-cosmeceuticals
#16
Ellinor R Quay, Yunyoung C Chang, Emmy Graber
<p>As the market for South Korean skin care products grows in the U.S. and worldwide, consumers will increasingly seek advice from dermatologists regarding their efficacy. In this paper, the evidence behind the anti-aging and skin whitening activity of ingredients in the most popular South Korean skin care products was reviewed and critically evaluated. Industry profit data from Euromonitor was obtained to identify the top cosmeceutical brands by retail value in South Korea. The top selling products and their ingredients were then identified from individual brand websites...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28402272/ginkgolic-acids-inhibit-migration-in-breast-cancer-cells-by-inhibition-of-nemo-sumoylation-and-nf-%C3%AE%C2%BAb-activity
#17
Sami Hamdoun, Thomas Efferth
Ginkgolic acids (GA), a group of alkyl phenols found in crude extracts of Ginkgo biloba leaves, are known to have anticancer activity, but their mode of action is not well understood. Our aim in this study was to investigate the anti-migratory activity of seven GA against breast cancer cells and to determine the molecular mechanism behind this activity. All seven GA and their mixture inhibited wound healing in MCF-7 and MDA-MB 231 breast cancer cells. None of the compounds nor the mixture showed cytotoxicity towards the two cell lines, if tested by the resazurin assay...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394269/ginkgolide-a-ameliorates-lps-induced-inflammatory-responses-in-vitro-and-in-vivo
#18
Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun, Yuxin Li
Ginkgolide A (GA) is a natural compound isolated from Ginkgo biloba and has been used to treat cardiovascular diseases and diabetic vascular complications. However, only a few studies have been conducted on the anti-inflammatory effects of GA. In particular, no related reports have been published in a common inflammation model of lipopolysaccharide (LPS)-stimulated macrophages, and the anti-inflammatory mechanisms of GA have not been fully elucidated. In the present study, we extensively investigated the anti-inflammatory potential of GA in vitro and in vivo...
April 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28391531/efficacy-of-steroid-therapy-based-on-symptomatic-and-functional-improvement-in-patients-with-vestibular-neuritis-a-prospective-randomized-controlled-trial
#19
Myung Hoon Yoo, Chan Joo Yang, Shin Ae Kim, Marn Joon Park, Joong Ho Ahn, Jong Woo Chung, Hong Ju Park
The aim of this study was to examine the efficacy of methylprednisolone in vestibular neuritis (VN) by objective and subjective measures. This prospective controlled randomized study was conducted at one tertiary hospital. Twenty-nine VN patients were randomized to either the steroid (n = 15) or the control (n = 14) group. The steroid group received methylprednisolone for 2 weeks, whereas control patients did not; both groups underwent regular vestibular exercises and were prescribed a Ginkgo biloba...
June 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28390940/ginkgo-biloba-l-attenuates-spontaneous-recurrent-seizures-and-associated-neurological-conditions-in-lithium-pilocarpine-rat-model-of-temporal-lobe-epilepsy-through-inhibition-of-mammalian-target-of-rapamycin-pathway-hyperactivation
#20
Arindam Ghosh Mazumder, Pallavi Sharma, Vikram Patial, Damanpreet Singh
ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgo biloba L. (Ginkgoaceae) has been widely used in traditional medicine for variety of neurological conditions particularly behavioral and memory impairments. AIM OF THE STUDY: The present study was envisaged to explore the effect of a standardized fraction of Ginkgo biloba leaves (GBbf) in rat model of lithium-pilocarpine induced spontaneous recurrent seizures, and associated behavioral impairments and cognitive deficit. MATERIALS AND METHODS: Rats showing appearance of spontaneous recurrent seizures following lithium pilocarpine (LiPc)-induced status epilepticus (SE) were treated with different doses of GBbf or vehicle for subsequent 4 weeks...
May 23, 2017: Journal of Ethnopharmacology
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