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Ginkgo biloba

Xiao-Fang Huang, Song-Zhao Zhang, Ya-Yu You, Na Zhang, Hong Lu, Alan Daugherty, Xiao-Jie Xie
Abdominal aortic aneurysms (AAAs) are a chronic vascular disease characterized by pathological luminal dilation. Aortic rupture is the fatal consequence of AAAs. Ginkgo biloba extracts (GBEs), a natural herb extract widely used as food supplements, drugs, and cosmetics, has been reported to suppress development of calcium chloride-induced AAAs in mice. Calcium chloride-induced AAAs do not rupture, while angiotensin II (AngII)-induced AAAs in mice have high rate of aortic rupture, implicating potentially different mechanisms from calcium chloride-induced AAAs...
May 18, 2018: Acta Pharmacologica Sinica
Ao Wang, Qiwei Yang, Qiuju Li, Xiaonan Wang, Shuhong Hao, Jincheng Wang, Ming Ren
BACKGROUND The oxidative stress environment of pathological tissue has an adverse effect on the survival of bone marrow mesenchymal stem cells (BMSCs) transplantation. Ginkgo biloba L. extract (EGB) has a potent antioxidant effect. In this research, we assessed the protective effects of EGB and EGB-Containing Serum (EGB CS) on BMSCs against injury induced by hydrogen peroxide (H2O2). MATERIAL AND METHODS BMSCs were pretreated with EGB or EGB CS and treated with H2O2. The cell counting kit-8 (CCK-8) method was utilized to detect cell viability...
May 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Chan Wu, Yong Xiang Wei, Jayant Marian Pinto, Jun Tian, Xian Dao Yuan, Xiao Jun Zhan
Objective: To determine whether ginkgo biloba extract(GBE)combined with dexamethasone(DEX)plays a role in the treatment of allergic rhinitis-related olfactory dysfunction using an animal model. Method: Six week old BALB/C mice were sensitized and challenged with ovalbumin.30 sensitized mice were divided into three groups:Group 1 was given high-dose GBE and DEX(n=10);Group 2 was given low dose GBE and DEX(n=10);Group 3 was given DEX alone(n=10).We assessed the histology of the olfactory mucosa and serum IL-4,IFN-γ,and caspase 1...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Lihu Zhang, Tingting Wu, Wei Xiao, Zhenzhong Wang, Gang Ding, Linguo Zhao
In the present study, the performance and separation characteristics of six macroporous resins for the enrichment and purification of total ginkgo flavonoid O -glycosides (TGFs) (quercetin (I), kaempferol (II), isorhamnetin (III)) from Ginkgo Biloba extracts (EGB) are evaluated. The adsorption and desorption properties of TGFs are studied on macroporous resins, including D101, D201, AB-8, HPD400, D301, and D311. Along with the results, AB-8 resin exhibits the best adsorption and desorption capacity for these three ginkgo flavonoid O -glycosides among the six resins...
May 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Natasha R Catlin, Bradley J Collins, Scott S Auerbach, Stephen S Ferguson, James M Harnly, Chris Gennings, Suramya Waidyanatha, Glenn E Rice, Stephanie L Smith-Roe, Kristine L Witt, Cynthia V Rider
No abstract text is available yet for this article.
May 9, 2018: Food and Chemical Toxicology
Hong Liu, Li-Ping Tan, Xin Huang, Yi-Qiu Liao, Wei-Jian Zhang, Pei-Bo Li, Yong-Gang Wang, Wei Peng, Zhong Wu, Wei-Wei Su, Hong-Liang Yao
Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3- O -α-l-glucoside, 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yanying Hu, Qingyuan Hua, Guojuan Sun, Kunpeng Shi, Huitu Zhang, Kai Zhao, Shiru Jia, Yujie Dai, Qingli Wu
The toxic ginkgolic acids are the main safety concern for the application of Ginkgo biloba. In this study, the degradation ability of salicylic acid decarboxylase (SDC) for ginkgolic acids was examined using ginkgolic acid C15:1 as a substrate. The results indicated that the content of ginkgolic acid C15:1 in Ginkgo biloba seeds was significantly decreased after 5 h treatment with SDC at 40 °Cand pH 5.5. In order to explore the structure of SDC and the interaction between SDC and substrates, homology modeling, molecular docking and molecular dynamics were performed...
May 2, 2018: Computational Biology and Chemistry
Hongxiang Li, Xiaoyuan Sun, Fan Yu, Lijia Xu, Jianhua Miu, Peigen Xiao
Based on compelling experimental and clinical evidence, Ginkgo biloba L. exerts a beneficial effect in ameliorating mild to moderate dementia in patients with Alzheimer’s disease (AD) and other neurological disorders, although the pharmacological mechanisms remain unknown. In the present study, compounds, their putative target proteins identified using an inverse docking approach, and clinically tested AD-related target proteins were systematically integrated together with applicable bioinformatics methods in silico ...
May 10, 2018: Nutrients
Dan J Siskind, Michael Lee, Arul Ravindran, Qichen Zhang, Evelyn Ma, Balaji Motamarri, Steve Kisely
BACKGROUND: Although clozapine is the most effective medication for treatment refractory schizophrenia, only 40% of people will meet response criteria. We therefore undertook a systematic review and meta-analysis of global literature on clozapine augmentation strategies. METHODS: We systematically reviewed PubMed, PsycInfo, Embase, Cochrane Database, Chinese Biomedical Literature Service System and China Knowledge Resource Integrated Database for randomised control trials of augmentation strategies for clozapine resistant schizophrenia...
May 1, 2018: Australian and New Zealand Journal of Psychiatry
Qingchuan Hu, Peng Shen, Shunjie Bai, Meixue Dong, Zihong Liang, Zhi Chen, Wei Wang, Haiyang Wang, Siwen Gui, Pengfei Li, Peng Xie
Purpose: Ginkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects of DG and venlafaxine (for comparison) on behavioral and metabolite changes in the PFC using mice models and gas chromatography-mass spectrometry-based metabolomics. Materials and methods: Mice were randomly divided into control (saline), DG (12...
2018: Neuropsychiatric Disease and Treatment
Man-Zhong Li, Yi Zhang, Hai-Yan Zou, Jun-Yao Ouyang, Yu Zhan, Le Yang, Brian Chi-Yan Cheng, Lei Wang, Qiu-Xia Zhang, Jian-Feng Lei, Yuan-Yuan Zhao, Hui Zhao
EGb 761 is a standardized natural extract from Ginkgo biloba leaf that has shown neuroprotective effects after ischemic stroke. This study aimed to use magnetic resonance imaging (MRI) to noninvasively evaluate whether EGb 761 promotes neurovascular restoration and axonal remodeling in a rat model of focal cerebral ischemia. Male Sprague-Dawley rats were subjected to permanent right middle cerebral artery occlusion (MCAO) and treated with EGb 761 (60 mg/kg) or saline intragastrically once daily for 15 days starting 6 h after MCAO...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nora Hohmann, Eva M Wolf, Philippe Rigault, Wenbin Zhou, Markus Kiefer, Yunpeng Zhao, Cheng-Xin Fu, Marcus A Koch
BACKGROUND: At the end of the Pliocene and the beginning of Pleistocene glaciation and deglaciation cycles Ginkgo biloba went extinct all over the world, and only few populations remained in China in relict areas serving as sanctuary for Tertiary relict trees. Yet the status of these regions as refuge areas with naturally existing populations has been proven not earlier than one decade ago. Herein we elaborated the hypothesis that during the Pleistocene cooling periods G. biloba expanded its distribution range in China repeatedly...
April 27, 2018: BMC Genomics
Guisheng Zhou, Jiayan Ma, Yuping Tang, Xinmin Wang, Jing Zhang, Jin-Ao Duan
In the present study, the process of ultrasonic assisted enzymatic extraction (UAEE), followed by macroporous resin purification, was successfully developed to achieve maximal recovery of flavonoids and ginkgolides from Ginkgo biloba fallen leaves (GBFL). Three effective extracted factors, including UAE power, EtOH%, and the amount of cellulase were screened by Plackett⁻Burman design (PBD). The important variables were further optimized by rotatable central composite design (RCCD). After the combination of PBD and RCCD, the resulting optimal UAEE conditions were as follows: UAE power of 218 W; EtOH% of 68%; the amount of cellulase of 8...
April 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ya Nan Ruan, Sheng Xu, Long Guo, Ming Zhu Zhu, Cong Wang, Shu Yuan Li, Hong Yan Wang
By using the open top chambers (OTCs) fumigation method, this paper investigated the changes of foliar injury, level of reactive oxygen species (ROS), activities and gene expression of antioxidant enzymes in Ginkgo biloba leaves under different ozone (ambient ozone≈40, 80, 160, 200 nmol·mol-1 ) concentrations, in order to study the effects of elevated ozone (O3 ) concentrations on reactive metabolism. The results showed that the obvious foliar injuries were observed in 160 and 200 nmol·mol-1 O3 treatments, while no visible injury was observed in 80 nmol·mol-1 O3 and ambient O3 treatments...
November 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Jinfan Tian, Yanfei Liu, Yue Liu, Keji Chen, Shuzheng Lyu
Diabetes was induced in high-fat diet-fed ApoE-/- mice via administration of low-dose streptozotocin (STZ) for five days. Mice were then treated with GBE (200 or 400 mg/kg) by gastric gavage daily for 12 weeks. Mice in the untreated diabetic group received saline instead, and nondiabetic C57BL/6J mice served as controls. Collagen І and ІІІ mRNA expression was measured by real-time PCR. TNF- α , IL-1 β mRNA levels, and NF- κ B expression were determined to analyze intramyocardial inflammation. Hallmarks of endoplasmic reticulum stress- (ERS-) related apoptosis pathways, including phosphorylated c-Jun N-terminal kinase (p-JNK), C/EBP homologous protein (CHOP), caspase-12, and cleaved caspase-3, were analyzed by Western blotting...
2018: Oxidative Medicine and Cellular Longevity
Gallant K L Chan, Winnie W H Hu, Zoey X Zheng, M Huang, Yan X Y Lin, Caroline Y Wang, Amy G W Gong, X Y Yang, Karl W K Tsim, Tina T X Dong
Dementia is a persistent disorder of the mental processes and is strongly related to depression. However, the performance of current antidepression medicine is far from satisfactory. Herbal extract provides an excellent source to identify compounds for possible drug development against depression. Here, HerboChips were employed to search herbal compounds that could bind nerve growth factor (NGF). By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba , showed a strong binding to NGF...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ming Lyu, Ying Cui, Tiechan Zhao, Zhaochen Ning, Jie Ren, Xingpiao Jin, Guanwei Fan, Yan Zhu
Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pharmacology analysis, we compared transcriptome profiles of brain and heart ischemia reperfusion injury in C57BL/6J mice to identify common and differential target genes by SXNI. Models for myocardial ischemia reperfusion injury (MIRI) by ligating left anterior descending coronary artery (LAD) for 30 min ischemia and 24 h reperfusion and cerebral ischemia reperfusion injury (CIRI) by middle cerebral artery occlusion (MCAO) for 90 min ischemia and 24 h reperfusion were employed to identify the common mechanisms of SXNI on both cerebral and myocardial ischemia reperfusion...
2018: Frontiers in Pharmacology
Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Heshu Sulaiman Rahman, Abdullah Rasedee
Background and aim: Type 2 diabetes mellitus (T2DM) is one of the major diseases confronting the health care systems. In diabetes mellitus (DM), combined use of oral hypoglycemic medications has been shown to be more effective than metformin (Met) alone in glycemic control. This study determined the effects of Ginkgo biloba (GKB) extract as an adjuvant to Met in patients with uncontrolled T2DM. Subjects and methods: Sixty T2DM patients were recruited in a randomized, placebo-controlled, double-blinded, and multicenter trial...
2018: Drug Design, Development and Therapy
Matthew Haworth, Claire M Belcher, Dilek Killi, Rebecca A Dewhirst, Alessandro Materassi, Antonio Raschi, Mauro Centritto
Global warming events have coincided with turnover of plant species at intervals in Earth history. As mean global temperatures rise, the number, frequency and duration of heat-waves will increase. Ginkgo biloba was grown under controlled climatic conditions at two different day/night temperature regimes (25/20 °C and 35/30 °C) to investigate the impact of heat stress. Photosynthetic CO2 -uptake and electron transport were reduced at the higher temperature, while rates of respiration were greater; suggesting that the carbon balance of the leaves was adversely affected...
April 18, 2018: Scientific Reports
Félix Forest, Justin Moat, Elisabeth Baloch, Neil A Brummitt, Steve P Bachman, Steffi Ickert-Bond, Peter M Hollingsworth, Aaron Liston, Damon P Little, Sarah Mathews, Hardeep Rai, Catarina Rydin, Dennis W Stevenson, Philip Thomas, Sven Buerki
Driven by limited resources and a sense of urgency, the prioritization of species for conservation has been a persistent concern in conservation science. Gymnosperms (comprising ginkgo, conifers, cycads, and gnetophytes) are one of the most threatened groups of living organisms, with 40% of the species at high risk of extinction, about twice as many as the most recent estimates for all plants (i.e. 21.4%). This high proportion of species facing extinction highlights the urgent action required to secure their future through an objective prioritization approach...
April 16, 2018: Scientific Reports
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