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mechanical ventilation newborn

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https://www.readbyqxmd.com/read/29910548/clinicoetiological-pattern-and-outcome-of-neonates-requiring-mechanical-ventilation-study-in-a-tertiary-care-centre
#1
Mohini Yadav, Gauri Chauhan, A K Bhardwaj, P D Sharma
The clinical and etiological pattern of ventilated newborns, their outcome in relation to morbidity and mortality was studied with 50 ventilated newborns, including outborns. M:f ratio was 2.1:1. The most common gestational age 28-36 weeks (60%) and mostly were appropriate for gestational age (66%). Survival rate 40% (20/50) being directly proportional to the gestational age and intrauterine growth pattern ( P < 0.01). Babies by LSCS Lower Segment Cessarian Section survived more than born by normal vaginal delivery (46...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910465/neural-breathing-patterns-in-preterm-newborns-supported-with-non-invasive-neurally-adjusted-ventilatory-assist
#2
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Gloria Galán Henríquez, Sonia Rivero Rodríguez, Alberto Hernández Gómez
OBJECTIVE: To characterize the neural breathing pattern in preterm infants supported with non-invasive neurally adjusted ventilatory assist (NIV-NAVA). STUDY DESIGN: Single-center prospective observational study. The electrical activity of the diaphragm (EAdi) was periodically recorded in 30-second series with the Edi catheter and the Servo-n software (Maquet, Solna, Sweden) in preterm infants supported with NIV-NAVA. The EAdiPeak , EAdiMin , EAdiTonic , EAdiPhasic , neural inspiratory, and expiratory times (nTi and nTe) and the neural respiratory rate (nRR) were calculated...
June 18, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29905634/ability-to-assent-in-pediatric-critical-care-research-a-prospective-environmental-scan-of-two-canadian-picus
#3
Katharine J O'Hearn, Dori-Ann Martin, Maryse Dagenais, Kusum Menon
OBJECTIVES: To determine the number of patients considered not appropriate to approach for assent within the first 24 hours of PICU admission. DESIGN: Exploratory prospective 1-month environmental scan. SETTING: Two tertiary Canadian PICUs. PATIENTS: Ninety patients age newborn to 17 years old admitted to the PICU during September 2016 (Site 1) or May 2017 (Site 2). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: At PICU admission, 81% of patients were deemed not appropriate to approach for assent most commonly due to age, influence of psychotropic medications, and/or mechanical ventilation...
June 13, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29895840/altered-metabolites-in-newborns-with-persistent-pulmonary-hypertension
#4
Martina A Steurer, Scott Oltman, Rebecca J Baer, Sky Feuer, Liang Liang, Randi A Paynter, Larry Rand, Kelli K Ryckman, Roberta L Keller, Laura L Jelliffe-Pawlowski
BACKGROUND: There is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN) METHODS: Nested case-control study from population-based database. Cases were infants with ICD-9 code for PPHN receiving mechanical ventilation. Controls receiving mechanical ventilation were matched 2:1 for gestational age, sex, birth weight, parenteral nutrition administration, and age at NBS collection...
June 12, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29894205/elafin-treatment-rescues-egfr-klf4-signaling-and-lung-cell-survival-in-ventilated-newborn-mice
#5
Miguel A Alejandre Alcazar, Mark Kaschwich, Robert Ertsey, Stefanie Preuss, Carlos Milla, Sana Mujahid, Juliet Masumi, Suleman Khan, Lucia M Mokres, Lu Tian, Jasmine Mohr, Dharmesh V Hirani, Marlene Rabinovitch, Richard D Bland
RATIONALE: Mechanical ventilation with O2 -rich gas (MV-O2 ) inhibits alveologenesis and lung growth. We showed that MV-O2 increases elastase activity and apoptosis in lungs of newborn mice; elastase inhibition by elafin suppressed apoptosis and enabled lung growth. In pilot studies, MV-O2 reduced lung expression of pro-survival factors, pEGFR and Klf4. OBJECTIVES: Determine if apoptosis and lung growth arrest evoked by MV-O2 reflect disrupted pEGFR-Klf4 signaling, which elafin treatment preserves...
June 12, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29850636/preterm-neonates-with-respiratory-distress-syndrome-ventilator-induced-lung-injury-and-oxidative-stress
#6
Clarissa Gutiérrez Carvalho, Renato Soibelmann Procianoy, Eurico Camargo Neto, Rita C Silveira
Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1 β , IL-10, and IL-8 and TNF- α in preterm newborns under mechanical ventilation (MV) in their first two days. Methods . Prospective cohort including neonates with severe respiratory distress...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29793868/lower-distending-pressure-improves-respiratory-mechanics-in-congenital-diaphragmatic-hernia-complicated-by-persistent-pulmonary-hypertension
#7
David Guevorkian, Sebastien Mur, Eric Cavatorta, Laurence Pognon, Thameur Rakza, Laurent Storme
OBJECTIVE: To investigate the effects of distending pressures on respiratory mechanics and pulmonary circulation in newborn infants with congenital diaphragmatic hernia (CDH) and persistent pulmonary hypertension (PPHN). STUDY DESIGN: In total, 17 consecutive infants of ≥37 weeks of gestational age with CDH and PPHN were included in this prospective, randomized, crossover pilot study. Infants were assigned randomly to receive 2 or 5 cmH2 O of positive end-expiratory pressure (PEEP) for 1 hour in a crossover design...
May 21, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29790141/-using-trm-to-enhance-the-accuracy-of-ventilator-associated-pneumonia-preventive-measures-implemented-by-neonatal-intensive-care-unit-medical-staffs
#8
Yu-Ting Huang, Chao-Ya Huang, Hsiu-Ya Su, Chen-Te Ma
BACKGROUND & PROBLEMS: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the neonatal intensive care unit (NICU). The average VAP infection density was 4.7‰ in our unit between June and August 2015. The results of a status survey indicated that in-service education lacked specialization, leading to inadequate awareness among staffs regarding the proper care of newborns with VAP and a lack of related care guides. This, in turn, resulted in inconsistencies in care measures for newborns with VAP...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29780032/severe-outcomes-associated-with-respiratory-viruses-in-newborns-and-infants-a-prospective-viral-surveillance-study-in-jordan
#9
Najwa Khuri-Bulos, Lindsey Lawrence, Bhinnata Piya, Li Wang, Christopher Fonnesbeck, Samir Faouri, Asem Shehabi, Sten H Vermund, John V Williams, Natasha B Halasa
OBJECTIVE: To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). DESIGN: Prospective cohort study. SETTING: A government hospital serving low-income and middle-income population in Amman, Jordan. PARTICIPANTS: Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29756460/inhaled-fasudil-lacks-pulmonary-selectivity-in-thromboxane-induced-acute-pulmonary-hypertension-in-newborn-lambs
#10
Shawn F L Hanson, Michael H Terry, Dafne T Moretta, Gordon G Power, Sean M Wilson, Farzana Alam, Fakhrul Ahsan, Arlin B Blood, Paresh C Giri
INTRODUCTION: Pulmonary hypertension (PH) is a potentially deadly disease for infants and adults with few existing medical interventions and no cure. In PH, increased blood pressure in the pulmonary artery eventually leads to heart failure. Fasudil, an antagonist of Rho-kinase, causes vasodilation leading to decreased systemic artery pressure and pulmonary artery pressure (PAP). This study compared the effects of fasudil administered as either an intravenous infusion or inhaled aerosol in newborn lambs...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29746013/accuracy-of-oscillatory-pressure-measured-by-mechanical-ventilators-during-high-frequency-oscillatory-ventilation-in-newborns
#11
Chiara Veneroni, Marta Tossici, Emanuela Zannin, Ilaria Milesi, Raffaele L Dellaca'
BACKGROUND: Oscillatory pressure (ΔP) measurement during high frequency oscillatory ventilation (HFOV) is technically challenging and influenced by all the components of the measurement system. OBJECTIVES: To evaluate the differences between the ΔP delivered at the inlet of the endotracheal tube and those displayed by commercial neonatal mechanical ventilators and monitoring devices and to characterize how the ventilator circuit and the flowmeter proximal to the patient affect these differences...
May 10, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29745619/incidence-and-risk-factors-of-ventilator-associated-pneumonia-in-neonatal-intensive-care-unit-a-first-french-study
#12
Guillaume Geslain, Isabelle Guellec, Romain Guedj, Julia Guilbert, Sandrine Jean, Cécile Valentin, Maryne Demoulin, Yohann Soreze, Ricardo Carbajal, Pierre-Louis Leger, Jerome Rambaud
BACKGROUND: Ventilator-associated pneumonia (VAP) is a severe intensive complication and remains under estimated in neonatal intensive care unit (NICU). Center for Disease Control defined criteria for adults and pediatrics without neonatal criteria. The objective of this article was to evaluate the rate, the risks factors and the outcome of neonates suffering from ventilator-associated pneumonia in a French NICU. METHODS: We conducted a prospective observational study within a one-year period in our NICU...
May 9, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29721741/off-label-and-unlicensed-drug-use-in-hospitalized-newborns-in-a-saudi-tertiary-care-hospital-a-cohort-study
#13
Faizan Mazhar, Shahzad Akram, Nafis Haider, Muhammad Abdul Hadi, Jabeen Sultana
Objective To determine the extent of off-label and unlicensed prescribing in hospitalized newborns and to identify patient-related risk factors associated with off-label prescribing. Methods A prospective cohort study was conducted between January and March 2016 at a neonatology department of a tertiary-care hospital in the Eastern province. All consecutive admissions to all neonatal care levels meeting the inclusion and exclusion criteria were eligible for enrollment. All prescriptions were classified as off-label or unlicensed according to drug product monograph...
May 2, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29719811/unusual-long-survival-despite-severe-lung-disease-of-a-child-with-biallelic-loss-of-function-mutations-in-abca-3
#14
P El Boustany, R Epaud, C Grosse, F Barriere, E Grimont-Rolland, A Carsin, J C Dubus
Homozygous or compound heterozygous for frameshift or nonsense mutations in the ATP-binding cassette transporter A3 (ABCA3) is associated with neonatal respiratory failure and death within the first year of life without lung transplantation. We report the case of a newborn baby girl who developed severe respiratory distress soon after birth. She was diagnosed with compound heterozygous frameshift mutation of the ABCA3 gene. Despite extensive treatment (intravenous corticosteroids pulse therapy, oral corticosteroids, azithromycin, and hydroxychloroquine), she developed chronic respiratory failure...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29712500/effects-of-fentanyl-for-pain-control-and-neuroprotection-in-very-preterm-newborns-on-mechanical-ventilation
#15
Jie Qiu, Li Zhao, Yang Yang, Jing-Han Zhang, Yun Feng, Rui Cheng
OBJECTIVE: This study aimed to evaluate the cerebral protection effect of fentanyl infusion in very preterm infants in the first 72 h of mechanical ventilation. METHODS: In this double-blind, randomized, controlled trial, mechanically ventilated newborns (<32 weeks' gestational age) were randomized to fentanyl (continuous infusion of fentanyl) or placebo (continuous infusion of glucose, controls) in the first 72 h of the mechanical ventilation period. The premature infant pain profile (PIPP), cerebral blood flow velocity, neuron-specific enolase (NSE) concentrations in plasma samples, and cerebral function monitoring (CFM) recordings were evaluated...
May 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29704686/a-novel-nkx3-2-mutation-associated-with-perinatal-lethal-phenotype-of-spondylo-megaepiphyseal-metaphyseal-dysplasia-in-a-neonate
#16
Pelin Ozlem Simsek-Kiper, Can Kosukcu, Ozlem Akgun-Dogan, Rahsan Gocmen, Gulen Eda Utine, Tutku Soyer, Ayse Korkmaz-Toygar, Gen Nishimura, Mehmet Alikasifoglu, Koray Boduroglu
Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD) is an autosomal recessive skeletal dysplasia, characterized by disproportionate short stature with a short and stiff neck and trunk. SMMD is caused by inactivating mutations in NKX3-2, which encodes a homeobox-containing protein. Because of the rarity of the disorder, the diagnostic feature has not been fully established yet. We describe an affected newborn with dysmorphic facial features and severe short trunk. The patient required immediate intubation at the delivery room and duodenal atresia was detected during his course in neonatal intensive care unit...
April 25, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29667359/predicting-responses-to-mechanical-ventilation-for-preterm-infants-with-acute-respiratory-illness-using-artificial-neural-networks
#17
Katharine Brigham, Samir Gupta, John C Brigham
Infants born prematurely are particularly susceptible to respiratory illness due to underdeveloped lungs, which can often result in fatality. Preterm infants in acute stages of respiratory illness typically require mechanical ventilation assistance, and the efficacy of the type of mechanical ventilation and its delivery has been the subject of a number clinical studies. With recent advances in machine learning approaches, particularly deep learning, it may be possible to estimate future responses to mechanical ventilation in real time, based on ventilation monitoring up to the point of analysis...
April 17, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#18
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29607416/correlation-of-retinopathy-of-prematurity-with-bronchopulmonary-dysplasia
#19
Wojciech Podraza, Beata Michalczuk, Karolina Jezierska, Hanna Domek, Agnieszka Kordek, Beata Łoniewska, Monika Modrzejewska, Joanna Kot
Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) are diseases that occur only in preterm infants. The etiology of these disorders is multifactorial; however, it is believed that some of the factors in children presenting with BPD affect both the initiation and severity of ROP. The aim of the study was to evaluate the degree of clinical severity of ROP in infants with BPD compared to those without BPD. Methodology: Infants were divided into two groups: the BPD+ study group and BPD- control group...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29559762/pulmonary-atelectasis-in-newborns-with-clinically-treatable-diseases-who-are-on-mechanical-ventilation-clinical-and-radiological-aspects
#20
Mariana Chiaradia Dominguez, Beatriz Regina Alvares
Objective: To analyze the radiological aspects of pulmonary atelectasis in newborns on mechanical ventilation and treated in an intensive care unit, associating the characteristics of atelectasis with the positioning of the head and endotracheal tube seen on the chest X-ray, as well as with the clinical variables. Materials and Methods: This was a retrospective cross-sectional study of 60 newborns treated between 1985 and 2015. Data were collected from medical records and radiology reports...
January 2018: Radiologia Brasileira
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