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https://www.readbyqxmd.com/read/28431766/analysis-of-2-week-data-from-two-randomized-controlled-trials-conducted-in-subjects-with-frequent-heartburn-treated-with-esomeprazole-20-mg
#1
Philip O Katz, Anne Le Moigne, Charles Pollack
PURPOSE: These secondary analyses used data from 2 similarly designed studies in subjects experiencing frequent heartburn to evaluate the efficacy of esomeprazole 20 mg once daily for 2 weeks, which reflects the approved over-the-counter dosage and duration. METHODS: Subjects without endoscopically identified erosive esophagitis who were experiencing heartburn for ≥6 months and ≥4 of 7 days prior to baseline (study 1, N = 368; study 2, N = 349) were randomly assigned to receive double-blind treatment with esomeprazole 40 or 20 mg (administered as esomeprazole magnesium trihydrate 44...
April 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28430981/central-nervous-system-glp-1-receptors-regulate-islet-hormone-secretion-and-glucose-homeostasis-in-male-rats
#2
Lene Jessen, Eric P Smith, Yvonne Ulrich-Lai, James P Herman, Randy J Seeley, Darleen Sandoval, David D'Alessio
The glucagon-like peptide 1 (GLP-1) system plays an important role in blood glucose regulation, in great part through coordinate control of insulin and glucagon secretion. These effects are generally attributed to GLP-1 produced in peripheral sites, principally the intestine. GLP-1 is also produced in hindbrain neurons that signal through GLP-1 receptors (GLP-1r) expressed in brain regions involved in metabolic regulation. GLP-1 in the central nervous system (CNS) induces satiety, visceral illness, and stress responses...
April 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28426040/enhancement-of-the-hole-conducting-effect-of-nio-by-a-n2-blow-drying-method-in-printable-perovskite-solar-cells-with-low-temperature-carbon-as-the-counter-electrode
#3
T A Nirmal Peiris, Ajay K Baranwal, Hiroyuki Kanda, Shota Fukumoto, Shusaku Kanaya, Ludmila Cojocaru, Takeru Bessho, Tsutomu Miyasaka, Hiroshi Segawa, Seigo Ito
In this article, we demonstrate for the first time a mesoscopic printable perovskite solar cell (PSC) using NiO as the hole transporting material and low-temperature processed carbon as the counter electrode. A single deposition method assisted by N2 blow drying was used for the deposition of MAPbI3 on a TiO2/ZrO2/NiO screen-printed electrode. As the final step a low-temperature processing (i.e. 75 °C) carbon counter layer was fabricated on MAPbI3 by a blade coating method. It is found that the capping layer thickness of MAPbI3 has a significant effect on the device efficiency, especially when NiO is introduced as a hole transporting material into the structure...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28423277/controlling-the-intermediate-structure-of-an-ionic-liquid-for-f-block-element-separations
#4
Carter W Abney, Changwoo Do, Huimin Luo, Joshua Wright, Lilin He, Sheng Dai
Recent research has revealed molecular structure beyond the inner coordination sphere is essential in defining the performance of separations processes, but nevertheless remains largely unexplored. Here we apply small angle neutron scattering (SANS) and x-ray absorption fine structure (XAFS) spectroscopy to investigate the structure of an ionic liquid system studied for f-block element separations. SANS data reveal dramatic changes in the ionic liquid microstructure (~150 Å) which we demonstrate can be controlled by judicious selection of counter ion...
April 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28420773/are-direct-to-consumer-marketing-and-over-the-counter-sale-of-hearing-aids-beneficial-to-patients-with-hearing-loss-a-provider-s-perspective
#5
Kenneth P Thomas
No abstract text is available yet for this article.
March 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28420227/efficacy-and-tolerability-of-a-plant-based-multi-component-cream-ginetrox%C3%A2-in-vulvovaginal-disorders-of-the-genitourinary-syndrome-during-menopause
#6
Roberto Marrai, Giovanni Lissi, Stefano Togni, Giada Maramaldi, Marco Barbara, Luca Giacomelli
BACKGROUND: Genitourinary syndrome of menopause (GSM) is a symptomatic condition including vaginal dryness, irritation, dyspareunia and recurrent urinary tract infections which affects 40-54% of post-menopausal women. Although several estrogen-based therapies are available, it is generally preferable to avoid hormonal therapy, particularly in women with mild symptoms or at risk for estrogen-responsive neoplasia. Therefore, the most common treatment options are over-the-counter vaginal creams for symptomatic relief...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28419446/from-autonomy-to-divinity-the-cultural-socialization-of-moral-reasoning-in-an-evangelical-christian-community
#7
Allison DiBianca Fasoli
This study examined moral reasoning in parent-child conversations within a U.S. evangelical Christian community. The goal was to identify social-communicative processes that may promote the development of Divinity in children's moral reasoning. Sixteen parent-child dyads (6-9 years old) discussed hypothetical moral vignettes about failures to help peers in need. Analyses revealed that Divinity typically co-occurred with Autonomy in these conversations and that such co-occurrences typically happened through three distinct social-communicative processes, labeled "align," "scaffold," and "counter...
April 17, 2017: Child Development
https://www.readbyqxmd.com/read/28418620/fast-and-highly-sensitive-ionic-polymer-gated-ws2-graphene-photodetectors
#8
Jake D Mehew, Selim Unal, Elias Torres Alonso, Gareth F Jones, Saad Fadhil Ramadhan, Monica F Craciun, Saverio Russo
The combination of graphene with semiconductor materials in heterostructure photodetectors enables amplified detection of femtowatt light signals using micrometer-scale electronic devices. Presently, long-lived charge traps limit the speed of such detectors, and impractical strategies, e.g., the use of large gate-voltage pulses, have been employed to achieve bandwidths suitable for applications such as video-frame-rate imaging. Here, atomically thin graphene-WS2 heterostructure photodetectors encapsulated in an ionic polymer are reported, which are uniquely able to operate at bandwidths up to 1...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28417992/eluxadoline-efficacy-in-ibs-d-patients-who-report-prior-loperamide-use
#9
Brian E Lacy, William D Chey, Brooks D Cash, Anthony J Lembo, Leonard S Dove, Paul S Covington
OBJECTIVES: Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success. This analysis evaluated the efficacy of eluxadoline in patients previously treated with loperamide in two phase 3 studies. METHODS: Adults with IBS-D (Rome III criteria) were enrolled and randomized to placebo or eluxadoline (75 or 100 mg) twice daily for 26 (IBS-3002) or 52 (IBS-3001) weeks. Patients reported loperamide use over the previous year and recorded their rescue loperamide use during the studies...
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28416070/-intentional-suicide-with-cyclizine
#10
Nikolaj Preus Hatting, Peter Martin Hansen
Cyclizine is an antihistamine with a sedative effect. In Denmark it is an over-the-counter drug, whereas it is a prescription drug in many other countries. It possesses anticholinergic and antiemetic properties, although the exact mechanism of action is unknown. At doses greater than 5 mg/kg potent side effects of anticholinergic character can be expected. This case report is a description of an intentional suicide with a dose greater than 70 mg/kg.
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28415065/acute-effect-of-biomechanical-muscle-stimulation-on-the-counter-movement-vertical-jump-power-and-velocity-in-division-i-football-players
#11
Bert H Jacobson, Taylor P Monaghan, John H Sellers, Eric C Conchola, Zach K Pope, Rob G Glass
Jacobson, BH, Monaghan, TP, Sellers, JH, Conchola, EC, Pope, ZK, and Glass, RG. Acute effect of biomechanical muscle stimulation on the counter-movement vertical jump power and velocity in division I football players. J Strength Cond Res 31(5): 1259-1264, 2017-Research regarding whole body vibration (WBV) largely supports such training augmentation in attempts to increase muscle strength and power. However, localized biomechanical vibration has not received the same attention. The purpose of this study was to assess peak and average power before and after acute vibration of selected lower-body sites in division I athletes...
May 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28411789/significant-cost-savings-from-treating-peristomal-irritant-contact-dermatitis-with-an-over-the-counter-spray
#12
Timothy C Michaelis, Brett C Neill, Vikas Patel, Daniel J Aires, Anand N Rajpara
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28411537/longitudinal-monitoring-of-whole-body-counter-nai-tl-detector-efficiency
#13
R J Shypailo
Assessing accuracy of radiation counting systems over time is critical. We examined long-term WBC performance in detail. Efficiency factors for 54 detectors were updated annually over several years. Newer efficiency values were compared with baseline and with annual values. Overall system efficiency has declined (-1.9% over 3 yrs) and appears to be doing so at an increasing rate. Having more specific performance data on individual components can make the process of system maintenance and repair more straightforward and efficient...
April 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28411319/fifty-year-spatiotemporal-analysis-of-landscape-changes-in-the-mont-saint-hilaire-unesco-biosphere-reserve-quebec-canada
#14
Marc Béliveau, Daniel Germain, Ana-Neli Ianăş
Diachronic analysis with a GIS-based classification of land-use changes based on aerial photographs, orthophotos, topographic maps, geotechnical reports, urban plans, and using landscape metrics has permitted insight into the driving forces responsible for landscape fragmentation in the Mont Saint-Hilaire (MSH) Biosphere Reserve over the period 1958-2015. Although the occurrence of exogenous factors, such as extreme weather and fires, can have a significant influence on the fragmentation of the territory in time and space, the accelerated development of the built environment (+470%) is nevertheless found to be primarily responsible for landscape fragmentation and the loss of areas formerly occupied by orchards, agriculture, and woodlands...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28405552/over-the-counter-and-prescription-medications-for-acne-a-cross-sectional-survey-in-a-sample-of-university-students-in-saudi-arabia
#15
Mohja D Alshehri, Abdulsalam T Almutairi, Asma M Alomran, Batool A Alrashed, Feroze Kaliyadan
INTRODUCTION AND BACKGROUND: Acne is a very common dermatological condition found among the adolescent population in Saudi Arabia. Many patients with acne try various forms of self-medication, over the counter medicines (OTC), and prescription medicines for the same. MATERIALS AND METHODS: This was a cross-sectional study among university students in the Kingdom of Saudi Arabia (KSA). A validated questionnaire was distributed to a convenience sample of university students to evaluate their knowledge and attitudes towards OTC (mainly) as well as prescription medicine for acne...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28405070/nitrous-oxide-induced-vitamin-b12-deficiency
#16
Lindsey Stockton, Cameron Simonsen, Susan Seago
Nitrous oxide is a gas that is odorless, colorless, and has a sweet taste at room temperature. Nitrous oxide has several uses, including in surgery and dentistry (referred to as "laughing gas"), in automotive racing, and in aerosol spray propellants. The aerosol spray propellants that typically use nitrous oxide are whipped cream canisters and cooking sprays. Unfortunately, these over-the-counter household items are a source of nitrous oxide that can be used for recreational use. The most popular is the use of industrial-grade canisters having the slang term "whippets...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28402480/cognitive-benefit-and-cost-of-acute-stress-is-differentially-modulated-by-individual-brain-state
#17
Nils Kohn, Erno J Hermans, Guillén Fernández
Acute stress is associated with beneficial as well as detrimental effects on cognition in different individuals. However, it is not yet known how stress can have such opposing effects. Stroop-like tasks typically show this dissociation: stress diminishes speed, but improves accuracy. We investigated accuracy and speed during a stroop-like task of 120 healthy male subjects after an experimental stress induction or control condition in a randomized, counter-balanced cross-over design; we assessed brain-behavior associations and determined the influence of individual brain connectivity patterns on these associations, which may moderate the effect and help identify stress resilience factors...
April 11, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28402415/single-versus-repeat-doses-of-misoprostol-for-treatment-of-early-pregnancy-loss-a-randomized-clinical-trial
#18
Yossi Mizrachi, Ann Dekalo, Ohad Gluck, Hadas Miremberg, Lotem Dafna, Ohad Feldstein, Eran Weiner, Jacob Bar, Ron Sagiv
STUDY QUESTION: Does repeat administration of misoprostol for early pregnancy loss increase the treatment success rate? SUMMARY ANSWER: Repeat administration of misoprostol does not increase the treatment success rate, and is associated with more analgesics use. WHAT IS KNOWN ALREADY: Misoprostol reduces the need for surgical evacuation and shortens the time to complete expulsion in patients with early pregnancy loss. However, the impact of repeat doses of misoprostol is not clear...
April 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28401798/most-frequently-reported-prescription-medications-and-supplements-in-couples-planning-pregnancy-the-life-study
#19
Kristin Palmsten, Katrina F Flores, Christina D Chambers, Lauren A Weiss, Rajeshwari Sundaram, Germaine M Buck Louis
OBJECTIVE: To identify frequently reported prescription medications and supplements among couples planning pregnancy because there is a lack of descriptive information on these agents in women and men who are trying to conceive. METHODS: Five hundred one couples enrolled in the Longitudinal Study of Infertility and the Environment, which took place between 2005 and 2009. Participants reported prescription medications as well as prescription and over-the-counter supplements used through interviews at study enrollment and through daily dairies during the 12-month follow-up...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28400999/mtor-function-and-therapeutic-targeting-in-breast-cancer
#20
REVIEW
Stephen H Hare, Amanda J Harvey
The mTOR pathway was discovered in the late 1970s after the compound and natural inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus. mTOR is serine/threonine kinase belonging to the phosphoinositide 3-kinase related kinase (PIKK) family. It forms two distinct complexes; mTORC1 and mTORC2. mTORC1 has a key role in regulating protein synthesis and autophagy whilst mTORC2 is involved in regulating kinases of the AGC family. mTOR signaling is often over active in multiple cancer types including breast cancer...
2017: American Journal of Cancer Research
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