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https://www.readbyqxmd.com/read/29792368/electrophysiological-multimodal-assessments-improve-outcome-prediction-in-traumatic-cervical-spinal-cord-injury
#1
Markus Hupp, Chiara Pavese, Lucas Bachmann, Rene Koller, Martin Schubert
Outcome prediction after spinal cord injury (SCI) is essential for early counseling and orientation of the rehabilitative intervention. Moreover, prognostication of outcome is crucial to achieve meaningful stratification when conceiving clinical trials. Neurophysiological examinations are commonly employed for prognostication after SCI, but whether neurophysiology could improve the functional prognosis based on clinical predictors remains open. Data of 224 patients included in the European Multicenter Study about Spinal Cord Injury were analyzed with bootstrapping analysis and multivariate logistic regression to derive prediction models of complete functional recovery in chronic stage after traumatic cervical SCI...
May 24, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29791761/nerve-action-potential-amplitudes-a-robust-marker-of-diabetic-peripheral-neuropathy
#2
Marie Monlun, Marie Hugo, Laurence Blanco, Kamel Mohammedi, Ahdab Rechdi, Laure Alexandre, Stéphane Poirot-Mazeres, Kalina Rajaobelina, Vincent Rigalleau
We were interested in the recent publication of Peterson et al. (1) who reported a progressive reduction of sural nerve amplitudes from 10.9μV to 7.0μV, during a ten year follow-up of 87 people with varying degrees of glucose intolerance. This reduction was more pronounced for people whose glucose tolerance deteriorated during the follow-up period, and paralleled their increasing HbA1c. In contrast, nerve conduction velocities only decreased from 47.6 to 45.8 m/s, without any significant relation to HbA1c This article is protected by copyright...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29789137/serratus-intercostal-interfascial-block-as-an-opioid-saving-strategy-in-supra-umbilical-open-surgery
#3
M T Fernández Martín, S López Álvarez, M A Pérez Herrero
INTRODUCTION: The administration of local anaesthetic in the serratus-intercostal space provides adequate analgesia in non-reconstructive breast surgery. The aim of this study was to evaluate whether the blockage of the last intercostal nerves (T7-T11) can lead to opioid savings in supra-umbilical open surgery procedures. MATERIAL AND METHODS: A prospective observational study was conducted on patients undergoing open supra-umbilical surgery under general anaesthesia and with a serratus-intercostal plane block [modified Blocking the bRanches of IntercostaL nerves in the Middle Axillary line (BRILMA)] as an associated analgesic strategy...
May 19, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29787402/a-pilot-study-of-a-novel-automated-somatosensory-evoked-potential-ssep-monitoring-device-for-detection-and-prevention-of-intraoperative-peripheral-nerve-injury-in-total-shoulder-arthroplasty-surgery
#4
Jason Chui, John M Murkin, Darren Drosdowech
INTRODUCTION: Peripheral nerve injury is a potentially devastating complication after total shoulder arthroplasty (TSA) surgery. This pilot study aimed to assess the feasibility of using an automated somatosensory evoked potential (SSEP) device to provide a timely alert/intervention to minimize intraoperative nerve insults during TSA surgery. METHODS: A prospective, single-arm, observational study was conducted in a single university hospital. The attending anesthesiologist monitored the study participants using the EPAD automated SSEP device and an intervention was made if there was an alert during TSA surgery...
May 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29784662/ibuprofen-decreases-spontaneous-activity-and-enhances-nerve-evoked-contractions-to-minimise-mitomycin-c-induced-bladder-dysfunction
#5
Eliza G West, Ryan Lang, Donna Sellers, Russ Chess-Williams, Catherine M McDermott
Inflammation may play a causal role in urological side effects reported following intravesical mitomycin C (MMC). Our aim was to investigate the effects of the non-steroidal anti-inflammatory drug ibuprofen (IBU) on the cytotoxic potency of MMC and the potential for IBU to protect against bladder dysfunction. Malignant (RT4, T24) and normal (UROtsa) urothelial lines were treated with MMC followed by ibuprofen, with cell viability and caspase-3 activity assessed. Female C57BL/6JArc mice (Saline/Control, MMC, Saline + IBU and MMC + IBU), received intravesical treatment (1hr) with saline or MMC (2mg/mL), with IBU (1mg/mL) delivered in drinking water (for 7-days)...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29782453/a-robust-approach-to-implementing-fascia-iliaca-compartment-nerve-blocks-in-hip-fracture-patients
#6
Mark G Williams, Zachary Jeffery, Henry W Corner, John Charity, Marina Quantick, Natalie Sartin
BACKGROUND: A clear imperative exists to optimize the preoperative pain management of hip fracture patients. Increasingly, fascia iliaca compartment blocks (FICBs) are being effectively utilized as an adjunct to oral analgesia in the emergency department. PURPOSE: We investigated the feasibility, safety, and delivery rate when junior doctors and specialist nurses are trained in FICBs delivery, alongside the introduction of a step-by-step proforma. METHODS: We conducted a retrospective study of hip fractures patients presenting preinterventions (n = 138) between October and December 2014 and postinterventions (n = 246) between April and August 2015...
May 2018: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29781504/epidural-versus-non-epidural-or-no-analgesia-for-pain-management-in-labour
#7
REVIEW
Millicent Anim-Somuah, Rebecca Md Smyth, Allan M Cyna, Anna Cuthbert
BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects on the mother and infant. This is an update of an existing Cochrane Review (Epidural versus non-epidural or no analgesia in labour), last published in 2011. OBJECTIVES: To assess the effectiveness and safety of all types of epidural analgesia, including combined-spinal-epidural (CSE) on the mother and the baby, when compared with non-epidural or no pain relief during labour...
May 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29780864/change-in-retinal-structural-anatomy-during-the-preclinical-stage-of-alzheimer-s-disease
#8
Cláudia Y Santos, Lenworth N Johnson, Stuart E Sinoff, Elena K Festa, William C Heindel, Peter J Snyder
Introduction: We conducted a 27-month longitudinal study of mid-life adults with preclinical Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare changes in volume and thickness in all retinal neuronal layers to those of age-matched healthy control subjects. Methods: Fifty-six older adults (mean age = 65.36 years) with multiple risk factors for AD completed spectral domain optical coherence tomography retinal imaging and cognitive testing at baseline...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780224/correlative-study-between-c-reactive-protein-clinical-severity-and-nerve-conduction-studies-in-guillain-barr%C3%A3-syndrome
#9
Yosria A Altaweel, Sawsan Abdelaziz, Hala A Fathy, Shimaa AbdelBadea
Background: Guillain-Barre' syndrome (GBS) is a serious autoimmune disorder in which the immune system attacks healthy nerve cells of the peripheral nervous system causing polyradiculoneuropathy which leads to weakness, numbness, and tingling, and can eventually cause paralysis. Autoimmune conditions like GBS can induce a high level of inflammation resulting in an increase in the C-reactive protein( CRP) production. The aim of this study is to assess the relationship between CRP level and the clinical severity as well as the electrophysiological findings of nerve conduction studies in patients with GBS...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29780222/role-of-concentric-needle-single-fiber-electromyography-in-detection-of-subclinical-motor-involvement-in-carpal-tunnel-syndrome
#10
Aliaa A Tawfeek, Amani M Nawito, Radwa M Azmy, Amr Hassan, Lamia M Afifi, Saly H Elkholy
Background: Conventional motor nerve conduction studies are usually normal in early and mild carpal tunnel syndrome (CTS). Single-fiber electromyography (SFEMG) measures the mean consecutive difference (MCD) as an expression of the variability in impulse transmission over the motor endplates and along the nerve fibers distally to the last branching point and along the muscle fibers.Application of concentric needle SFEMG in a group of CTS patients who showed pure sensory abnormalities in nerve conduction studies to examine for subclinical motor involvement...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29779092/neurodynamic-evaluation-and-nerve-conduction-studies-in-patients-with-forward-head-posture
#11
Tugba Ozudogru Celik, Burcu Duyur Cakit, Baris Nacir, Hakan Genc, Mehmet Onat Cakit, Aynur Karagoz
Forward head posture (FHP) is one of the most frequently seen problems. The aim of this study was to evaluate the neurodynamic tests and peripheral nerve conductions of upper extremity in patients with FHP. The study population included 100 patients with upper extremity and neck problems and 34 healthy individuals as a control group. Craniovertebral angle measurement was used to determine forward head posture. Stretch tests for radial, ulnar and median nerves were performed. Nerve conductions of bilateral median, radial, ulnar and medial antebrachial cutaneous (MAC) nerves were examined in all patients included in the study...
May 19, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29778132/cervical-vestibular-evoked-myogenic-potentials-cvemps-evoked-by-air-conducted-stimuli-in-patients-with-functional-neck-dissection
#12
Hasan Demirhan, Bahtiyar Hamit, Özgür Yiğit
OBJECTIVE: Cervical vestibular-evoked myogenic potentials (cVEMPs) are short-latency vestibulocollic reflexes. The damage on any point of the vestibulocollic reflex pathway could affect the cVEMPs. Whether neck dissection has an effect on the sacculocollic pathway, and consequently on cVEMPs, remains unexplored. The aim of this study was to evaluate the cVEMP findings in patients with functional neck dissection without vestibular symptoms. PATIENTS AND METHODS: This cross-sectional study design, 20 patients who had undergone unilateral neck dissection with sparing of the accessory nerve, SCM and internal jugular vein, were included...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29777714/efficiency-of-neuromuscular-electrical-stimulation-and-transcutaneous-nerve-stimulation-on-hemiplegic-shoulder-pain-a-prospective-randomized-controlled-trial
#13
Meimei Zhou, Fang Li, Weibo Lu, Junfa Wu, Song Pei
OBJECTIVE: To compare the efficacy of neuromuscular electrical stimulation (NMES) and transcutaneous nerve stimulation (TENS) on hemiplegic shoulder pain (HSP). DESIGN: This is a prospective randomized controlled trial (RCT). SETTING: A total of 184 HSP patients, aged 18-80 years, were recruited in the Rehabilitation Hospital from February 2014 to July 2016. The Ethics approval was obtained from the Institutional Review Board of the Hospital...
May 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29777675/brain-derived-microparticles-activate-microglia-macrophages-and-induce-neuroinflammation
#14
Hongtao Rong, Yueshan Fan, Mengchen Yang, Baoliang Zhang, Dongdong Sun, Zilong Zhao, Dong Wang, Weidong Fan, Jianhao Wang, Gang Gu, Fanjian Li, Xilei Liu, Chenxu Rao, Huijiao Chen, Yi Wang, Ye Tian, Jianning Zhang
Microparticles are cell fragments derived from damaged cells that are able to present an antigen from the parent cells to other cells to activate intracellular signaling pathways. Microparticles are closely related to the inflammatory response. Brain-derived microparticles (BDMPs) play an important role in brain injury. However, the inflammatory effect of BDMPs on microglia/macrophages remains unclear. The BDMPs were consumed by microglia/macrophages in vivo and in vitro. The BDMPs activated microglia/macrophages and changed their morphology in vitro...
May 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29775143/testing-the-effectiveness-and-the-contribution-of-experimental-supercharge-reversed-end-to-side-nerve-transfer
#15
Mustafa Nadi, Sudheesh Ramachandran, Abir Islam, Joanne Forden, Gui Fang Guo, Rajiv Midha
OBJECTIVE Supercharge end-to-side (SETS) transfer, also referred to as reverse end-to-side transfer, distal to severe nerve compression neuropathy or in-continuity nerve injury is gaining clinical popularity despite questions about its effectiveness. Here, the authors examined SETS distal to experimental neuroma in-continuity (NIC) injuries for efficacy in enhancing neuronal regeneration and functional outcome, and, for the first time, they definitively evaluated the degree of contribution of the native and donor motor neuron pools...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29774175/motor-interconnections-between-superior-and-inferior-laryngeal-nerves
#16
Emin Gurleyik
Introduction Anatomical studies on human cadavers have established anastomoses between laryngeal nerves. However, we need to functionally identify motor communication via these anastomoses between the recurrent laryngeal nerve (RLN) and the external branch of the superior laryngeal nerve (EBSLN) in living bodies. We aim to establish motor interconnections using intraoperative nerve monitoring (IONM). Methods IONM of 112 EBSLNs and RLNs in 62 thyroidectomy cases was used to establish motor functions of laryngeal nerves...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29773852/protective-effects-of-intraoperative-nerve-monitoring-ionm-for-recurrent-laryngeal-nerve-injury-in-thyroidectomy-meta-analysis
#17
Binglong Bai, Wuzhen Chen
Recurrent laryngeal nerve (RLN) injury is an intractable complication of thyroidectomy. Intraoperative nerve monitoring (IONM) was designed to prevent RLN injury. However, the results concerning the protective effect of IONM on RLN injury are still controversial. We searched all eligible databases from 1980 to 2017. Meta-analysis was performed to evaluate the effect of IONM on RLN injury. Sensitivity analysis was also conducted to check the stability of our results. There were 34 studies included in the analysis...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772247/internode-length-is-reduced-during-myelination-and-remyelination-by-neurofilament-medium-phosphorylation-in-motor-axons
#18
Eric Villalón, Devin M Barry, Nathan Byers, Katie Frizzi, Maria R Jones, Dan S Landayan, Jeffrey M Dale, Natalie L Downer, Nigel A Calcutt, Michael L Garcia
The distance between nodes of Ranvier, referred to as internode length, positively correlates with axon diameter, and is optimized during development to ensure maximal neuronal conduction velocity. Following myelin loss, internode length is reestablished through remyelination. However, remyelination results in short internode lengths and reduced conduction rates. We analyzed the potential role of neurofilament phosphorylation in regulating internode length during remyelination and myelination. Following ethidium bromide induced demyelination, levels of neurofilament medium (NF-M) and heavy (NF-H) phosphorylation were unaffected...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29770208/case-report-polyarteritis-nodosa-or-complicated-henoch-schonlein-purpura-a-rare-case
#19
Sajad Hasanzadeh, Seyedeh Maryam Alavi, Elahe Masnavi, Maryam Rohani, Saeid Jokar
Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium sized arteries. PAN is a rare disease and requires a high vilgilance for diagnosis. For instance, PAN and Henoch-Schonlein purpura (HSP) have narrowing differential diagnosis. Here, we report a case of PAN. Case presentation : Our patient was a 65 year old woman that came to hospital due to abdominal pain and skin lesion on the right upper and right lower extremities. All rheumatologic tests were negative. A biopsy of the skin lesion was reported as mild hyperkeratosis, slight spongiosis with intact basal layer...
2018: F1000Research
https://www.readbyqxmd.com/read/29768985/effects-of-monoclonal-antibodies-against-nerve-growth-factor-on-healthy-bone-and-joint-tissues-in-mice-rats-and-monkeys-histopathologic-biomarker-and-microcomputed-tomographic-assessments
#20
Kathryn E Gropp, Cathy S Carlson, Mark G Evans, Cedo M Bagi, William J Reagan, Susan I Hurst, David L Shelton, Mark A Zorbas
Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials of anti-NGF antibodies, some patients reported unexpected adverse events requiring total joint replacements, resulting in a partial clinical hold on all NGF inhibitors. Three nonclinical toxicology studies were conducted to evaluate the effects of tanezumab or the murine precursor muMab911 on selected bone and joint endpoints and biomarkers in cynomolgus monkeys, Sprague-Dawley rats, and C57BL/6 mice...
January 1, 2018: Toxicologic Pathology
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