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https://www.readbyqxmd.com/read/28183845/incidence-of-idiopathic-ventricular-arrhythmias-a-population-based-study
#1
Surksha Sirichand, Ammar M Killu, Deepak Padmanabhan, David O Hodge, Alanna M Chamberlain, Peter A Brady, Suraj Kapa, Peter A Noseworthy, Douglas L Packer, Thomas M Munger, Bernard J Gersh, Christopher J McLeod, Win-Kuang Shen, Yong-Mei Cha, Samuel J Asirvatham, Paul A Friedman, Siva K Mulpuru
BACKGROUND: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown. METHODS AND RESULTS: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28102966/histone-deacetylase-2-is-decreased-in-peripheral-blood-pro-inflammatory-cd8-t-and-nkt-like-lymphocytes-following-lung-transplant
#2
Greg Hodge, Sandra Hodge, Chien-Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral blood T and natural killer T (NKT)-like cells. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) upregulate/downregulate pro-inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102670/microfluidization-of-graphite-and-formulation-of-graphene-based-conductive-inks
#3
Panagiotis G Karagiannidis, Stephen A Hodge, Lucia Lombardi, Flavia Tomarchio, Nicolas Decorde, Silvia Milana, Ilya Goykhman, Yang Su, Steven V Mesite, Duncan N Johnstone, Rowan K Leary, Paul A Midgley, Nicola M Pugno, Felice Torrisi, Andrea C Ferrari
We report the exfoliation of graphite in aqueous solutions under high shear rate [∼ 10(8) s(-1)] turbulent flow conditions, with a 100% exfoliation yield. The material is stabilized without centrifugation at concentrations up to 100 g/L using carboxymethylcellulose sodium salt to formulate conductive printable inks. The sheet resistance of blade coated films is below ∼2Ω/□. This is a simple and scalable production route for conductive inks for large-area printing in flexible electronics.
February 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28092298/individualized-exercise-interventions-for-spinal-pain
#4
Deborah Falla, Paul W Hodges
Exercise is the most effective treatment for the management and prevention of spinal pain, yet on average it delivers small to moderate treatment effects, which are rarely long-lasting. This review examines the hypothesis that outcome of exercise interventions can be optimized when targeted towards the "right" patients and when tailored to address the neuromuscular impairments of each individual.
January 13, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28078667/philanthropy-in-health-professions-education-research-determinants-of-success
#5
Robert Paul, Elisa Hollenberg, Brian D Hodges
CONTEXT: Fund-raising is a new practice in medical education research. OBJECTIVES: This qualitative study explores a cross-sectional analysis of philanthropy in medical education in Canada and Europe and identifies some common characteristics in the fund-raising system, key roles and characteristics of research sites that have had success. METHODS: Medical education research sites that had received donations greater than Can$100 000 were identified by searching publicly available sources...
January 11, 2017: Medical Education
https://www.readbyqxmd.com/read/27998891/inflammatory-cytokines-and-lung-cancer-risk-in-3-prospective-studies
#6
Darren R Brenner, Anouar Fanidi, Kjell Grankvist, David C Muller, Paul Brennan, Jonas Manjer, Graham Byrnes, Allison Hodge, Gianluca Severi, Graham G Giles, Mikael Johansson, Mattias Johansson
To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malmö Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, interferon γ, tumor necrosis factor α, and granulocyte-macrophage colony-stimulating factor...
January 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27943333/endocardial-device-leads-in-patients-with-patent-foramen-ovale-echocardiographic-correlates-of-stroke-tia-and-mortality
#7
Shiva P Ponamgi, Vaibhav R Vaidya, Christopher V Desimone, Amit Noheria, David O Hodge, Joshua P Slusser, Naser M Ammash, Charles J Bruce, Alejandro A Rabinstein, Paul A Friedman, Samuel J Asirvatham
BACKGROUND: Echocardiographically detected patent foramen ovale (PFO) has been associated with stroke/transient ischemic attack (TIA) in patients with cardiac implantable electronic devices (CIED). We sought to evaluate the relationship between echocardiographic characteristics and risk of stroke/TIA and mortality in CIED patients with PFO. METHODS: In 6086 device patients, PFO was detected in 319 patients. A baseline echocardiogram was present in 250 patients, with 186 having a follow-up echocardiogram...
December 12, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27943113/significance-and-clinical-characteristics-of-atrial-fibrillation-post-epicardial-access
#8
Alan Sugrue, Ammar M Killu, David O Hodge, Christopher J McLeod, Thomas M Munger, Siva K Mulpuru, Douglas L Packer, Suraj Kapa, Samuel J Asirvatham, Paul A Friedman
INTRODUCTION: Epicardial access (EpiAcc) has become an important adjunct for ventricular tachycardia (VT) or premature ventricular complex (PVC) ablation. We hypothesized that post-procedural pericarditis may lead to an increased risk of atrial fibrillation (AF), and therefore assessed the incidence and clinical impact of post-procedural AF in patients undergoing EpiAcc. METHODS: We reviewed the records of all patients who underwent EpiAcc as part of an ablation procedure between January 1, 2004 and July 31, 2014 at Mayo Clinic Rochester...
December 9, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27940786/long-term-behavioral-problems-in-children-with-severe-malaria
#9
John Mbaziira Ssenkusu, James Steven Hodges, Robert Opika Opoka, Richard Idro, Elsa Shapiro, Chandy Chiramukhathu John, Paul Bangirana
BACKGROUND: Severe malaria in children is associated with long-term neurocognitive impairment, but it is unclear whether it is associated with long-term behavioral problems. METHODS: Children <5 years old with cerebral malaria (CM) or severe malarial anemia (SMA) treated at Mulago Hospital, Kampala, Uganda were assessed for behavioral outcomes at 0, 6, 12, and 24 months using the Child Behavior Checklist. Sample sizes at 0, 12, and 24 months were 122, 100, and 80 in the CM group, 130, 98, and 81 in the SMA group, and 149, 123, and 90 in healthy community control (CC) children, respectively...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27906831/bos-is-associated-with-increased-cytotoxic-pro-inflammatory-cd8-t-nkt-like-and-nk-cells-in-the-small-airways
#10
Greg Hodge, Sandra Hodge, Aeneas Yeo, Phan Nguyen, Emily Hopkins, Holmes-Liew Cl, Paul N Reynolds, Mark Holmes
BACKGROUND: Immunosuppression therapy following lung transplantation fails to prevent bronchiolitis obliterans syndrome (BOS) in many patients, primarily a disease of the small airways. We have reported that BOS is associated with a lack of suppression of cytotoxic mediators, and pro-inflammatory cytokines, in peripheral blood T, NKT-like (particularly CD8+) and NK cells. We also showed a loss of glucocorticoid receptor (GCR) in pro-inflammatory lymphocytes following transplant. It is unknown whether these pro-inflammatory lymphocytes target the small and/or large airways in BOS...
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27857147/molecular-mechanism-of-action-of-antimalarial-benzoisothiazolones-species-selective-inhibitors-of-the-plasmodium-spp-mep-pathway-enzyme-ispd
#11
Kathryn E Price, Christopher M Armstrong, Leah S Imlay, Dana M Hodge, C Pidathala, Natalie J Roberts, Jooyoung Park, Marwa Mikati, Raman Sharma, Alexandre S Lawrenson, Niraj H Tolia, Neil G Berry, Paul M O'Neill, Audrey R Odom John
The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d]isothiazol-3(2H)-ones as species-selective inhibitors of Plasmodium spp. 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD), the third catalytic enzyme of the MEP pathway. 2-Phenyl benzo[d]isothiazol-3(2H)-ones display nanomolar inhibitory activity against P...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27816023/kinematics-and-kinetics-during-stair-ascent-in-individuals-with-gluteal-tendinopathy
#12
Kim Allison, Bill Vicenzino, Kim L Bennell, Tim V Wrigley, Alison Grimaldi, Paul W Hodges
BACKGROUND: Individuals with gluteal tendinopathy commonly report lateral hip pain and disability during stair ascent. This study aimed to compare kinematics and kinetics between individuals with and without gluteal tendinopathy during a step up task. METHODS: 35 individuals with unilateral gluteal tendinopathy and 35 pain-free controls underwent three-dimensional motion analysis of stance phase during stair ascent. An analysis of covariance was performed to compare hip, pelvis and trunk kinematic and kinetic variables between groups...
October 5, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27769261/steroid-resistance-in-copd-is-associated-with-impaired-molecular-chaperone-hsp90-expression-by-pro-inflammatory-lymphocytes
#13
Greg Hodge, Eugene Roscioli, Hubertus Jersmann, Hai B Tran, Mark Holmes, Paul N Reynolds, Sandra Hodge
BACKGROUND: Corticosteroid resistance is a major barrier to effective treatment of COPD. We have shown that the resistance is associated with decreased expression of glucocorticoid receptor (GCR) by senescent CD28nullCD8+ pro-inflammatory lymphocytes in peripheral blood of COPD patients. GCR must be bound to molecular chaperones heat shock proteins (Hsp) 70 and Hsp90 to acquire a high-affinity steroid binding conformation, and traffic to the nucleus. We hypothesized a loss of Hsp70/90 from these lymphocytes may further contribute to steroid resistance in COPD...
October 21, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27753239/application-of-shear-wave-elastography-to-estimate-the-stiffness-of-the-male-striated-urethral-sphincter-during-voluntary-contractions
#14
Ryan E Stafford, Rafeef Aljuraifani, François Hug, Paul W Hodges
OBJECTIVES: To investigate whether increases in stiffness can be detected in the anatomical region associated with the striated urethral sphincter during voluntary activation using shear wave elastography; to identify the location and area of the stiffness increase relative to the point of greatest dorsal displacement of the mid urethra (i.e. striated urethral sphincter); and to determine the relationship between muscle stiffness and contraction intensity. SUBJECTS AND METHODS: Ten healthy men participated...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27748530/sudden-death-and-its-risk-factors-after-atrioventricular-junction-ablation-and-pacemaker-implantation-in-patients-with-atrial-fibrillation
#15
Ru-Xing Wang, Hon-Chi Lee, Jia-Ping Li, David O Hodge, Yong-Mei Cha, Paul A Friedman, Thomas M Munger, Komandoor Srivathsan, Behzad B Pavri, Win-Kuang Shen
BACKGROUND: Although sudden death (SD) is a rare complication after atrioventricular junction (AVJ) ablation and permanent pacemaker implantation, the risk factors leading to this SD remain unknown. The purpose of this study was to investigate SD and its risk factors after ablate-and-pace strategy for rate control in atrial fibrillation (AF) patients during long-term follow-up. HYPOTHESIS: METHODS: From January 2005 to December 2009, we enrolled into this study 517 AF patients with AVJ ablation and right ventricular pacemaker implantation...
January 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/27738059/lead-extraction-outcomes-in-patients-with-congenital-heart-disease
#16
Erin A Fender, Ammar M Killu, Bryan C Cannon, Paul A Friedman, Christopher J Mcleod, David O Hodge, Craig S Broberg, Charles A Henrikson, Yong-Mei Cha
AIMS: Patients with congenital heart disease (CHD) are at increased risk for intracardiac device malfunction and infection that may necessitate extraction; however, the risk of extraction is poorly understood. This study addresses the safety of extraction in patients with structural heart disease and previous cardiac surgery. METHODS: This retrospective study included 40 CHD and 80 matched control patients, who underwent transvenous lead extractions between 2001 and 2014...
October 13, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27720935/systemic-inflammatory-profiles-and-their-relationships-with-demographic-behavioural-and-clinical-features-in-acute-low-back-pain
#17
David M Klyne, Mary F Barbe, Paul W Hodges
Systemic inflammation is linked with development and persistence of many pathological pain states. Although chronic phase inflammatory responses are well reported, the acute phase has received limited attention. Here we investigated circulating pro-inflammatory cytokines and C-reactive protein (CRP), and explored their relationships with symptom severity and other factors in acute low back pain (LBP). Ninety-nine individuals within two weeks of onset of acute LBP and 55 pain-free controls completed questionnaires related to their pain (visual analogue scale, VAS) and disability, behaviour, sleep quality and psychological status...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27707785/outcomes-of-lead-extraction-without-subsequent-device-reimplantation
#18
Mohammed A Al-Hijji, Ammar M Killu, Omid Yousefian, David O Hodge, Jae Yoon Park, Shrinivas Hebsur, Abdallah El Sabbagh, Victor G Pretorius, Michael J Ackerman, Paul A Friedman, Ulrika Birgersdotter-Green, Yong-Mei Cha
AIMS: Outcomes among patients who do not receive device reimplantation after cardiovascular implantable electronic device (CIED) extraction have not been well studied. The present study aims to investigate the outcomes of patients without device reimplantation after lead extraction and device removal. METHODS AND RESULTS: We retrospectively searched for consecutive patients who underwent CIED extraction at Mayo Clinic, Rochester, MN and University of California San Diego Medical Center from 2001 through 2012...
October 5, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27689709/the-effect-of-colonization-with-potentially-pathogenic-microorganisms-on-efferocytosis-in-chronic-obstructive-pulmonary-disease
#19
Sandra Hodge, Hubertus Jersmann, Paul N Reynolds
No abstract text is available yet for this article.
October 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27633027/utility-of-clinical-tests-to-diagnose-mri-confirmed-gluteal-tendinopathy-in-patients-presenting-with-lateral-hip-pain
#20
Alison Grimaldi, Rebecca Mellor, Phillipa Nicolson, Paul Hodges, Kim Bennell, Bill Vicenzino
PURPOSE: Gluteal tendinopathy (GT) is a source of lateral hip pain, yet common clinical diagnostic tests have limited validity. Patients with GT are often misdiagnosed, resulting in inappropriate management, including surgery. This study determined the diagnostic utility of clinical tests for GT, using MRI as the reference standard. METHODS: 65 participants with lateral hip pain were examined to evaluate the ability of clinical tests to detect MRI-determined GT (an increase in intratendinous signal intensity on T2-weighted images)...
September 15, 2016: British Journal of Sports Medicine
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