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Paul hodges

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https://www.readbyqxmd.com/read/29617053/efficacy-and-safety-of-rivaroxaban-compared-to-enoxaparin-in-treatment-of-cancer-associated-venous-thromboembolism
#1
Benjamin Simmons, Waldemar Wysokinski, Rayya A Saadiq, Dalene Bott-Kitslaar, Stanislav Henkin, Ana Casanegra, Charles Lenz, Paul Daniels, Haraldur Bjarnason, Emily Vargas, David Hodge, Sara J Holton, James R Cerhan, Charles Loprinzi, Robert McBane
BACKGROUND: Low molecular weight heparin (LMWH) is the guideline endorsed treatment for cancer associated venous thromboembolism (cVTE). Study objectives were to compare the efficacy and safety of rivaroxaban and enoxaparin in cVTE. METHODS: Using a cohort study design, consecutive patients with cVTE (3/1/2013-7/31/2016), enrolled in the Mayo Thrombophilia Clinic Direct Oral Anticoagulants Registry were compared to contemporary cancer patients receiving enoxaparin...
April 4, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29609898/real-time-pathophysiologic-correlates-of-left-atrial-appendage-thrombus-in-patients-who-underwent-transesophageal-guided-electrical-cardioversion-for-atrial-fibrillation
#2
Rowlens M Melduni, Bernard J Gersh, Waldemar E Wysokinski, Naser M Ammash, Paul A Friedman, David O Hodge, Krishnaswamy Chandrasekaran, Jae K Oh, Hon-Chi Lee
Although current guidelines advocate using the CHA2 DS2 -VASc score to assess the risk of stroke in patients with atrial fibrillation (AF), compared with transesophageal echocardiography (TEE), its ability to predict left atrial appendage thrombus (LAAT) is limited. We studied 3,324 consecutive patients with sustained AF from our prospective registry of patients who underwent first-time TEE-guided electrical cardioversion (ECV) from May 2000 through March 2012. The association of CHA2 DS2 -VASc score or TEE risk factors with the occurrence of LAAT was analyzed...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29597080/individual-variation-in-pain-sensitivity-and-conditioned-pain-modulation-in-acute-low-back-pain-impact-of-stimulus-type-sleep-psychological-and-lifestyle-factors
#3
David M Klyne, G Lorimer Moseley, Michele Sterling, Mary F Barbe, Paul W Hodges
Generalised hyperalgesia and impaired pain modulation are reported in chronic low back pain (LBP). Few studies have tested whether these features are present in the acute-phase. This study aimed to test for differences in pain presentation in early-acute LBP and evaluate the potential contribution of other factors to variation in sensitivity. Individuals within two weeks of onset of acute LBP (N=126) and pain-free controls (N=74) completed questionnaires related to their pain, disability, behaviour and psychological status before undergoing conditioned pain modulation (CPM) and pain threshold (heat, cold and pressure) testing at the back and forearm/thumb...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29496226/how-is-symptom-flare-defined-in-musculoskeletal-conditions-a-systematic-review
#4
REVIEW
Nathalia Costa, Manuela L Ferreira, Marita Cross, Joanna Makovey, Paul W Hodges
OBJECTIVE: To systematically review the definitions for "flare" in musculoskeletal conditions, the derivation processes, and validation of definitions for the 12 most burdensome musculoskeletal conditions. METHODS: A literature search was conducted in MEDLINE, EMBASE, CINAHL, AMED, PsycInfo and Lilacs to identify studies that investigated derivation or validation of a flare definition, which we considered as a phrase or group of domains. RESULTS: Reports of derivation of flare definitions were identified for 9/12 musculoskeletal conditions...
January 31, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29491031/state-dependent-judgement-bias-in-drosophila-evidence-for-evolutionarily-primitive-affective-processes
#5
Amanda Deakin, Michael Mendl, William J Browne, Elizabeth S Paul, James J L Hodge
Affective states influence decision-making under ambiguity in humans and other animals. Individuals in a negative state tend to interpret ambiguous cues more negatively than individuals in a positive state. We demonstrate that the fruit fly, Drosophila melanogaster , also exhibits state-dependent changes in cue interpretation. Drosophila were trained on a Go/Go task to approach a positive (P) odour associated with a sugar reward and actively avoid a negative (N) odour associated with shock. Trained flies were then either shaken to induce a purported negative state or left undisturbed (control), and given a choice between: air or P; air or N; air or ambiguous odour (1 : 1 blend of P : N)...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29486364/gluteal-tendinopathy-and-hip-osteoarthritis-different-pathologies-different-hip-biomechanics
#6
Kim Allison, Michelle Hall, Paul W Hodges, Tim V Wrigley, Bill Vicenzino, Yong-Hao Pua, Ben Metcalf, Alison Grimaldi, Kim L Bennell
BACKGROUND: Gluteal tendinopathy (GT) and hip osteoarthritis (OA) are the most common causes of hip pain and associated disability in older adults. Pain and altered walking biomechanics are common to both conditions. This study aimed to compare three-dimensional walking biomechanics between individuals with unilateral, symptomatic GT and HOA. METHODS: Sixty individuals with symptomatic unilateral GT confirmed by magnetic-resonance-imaging and 73 individuals with symptomatic unilateral HOA (Kellgren-Lawrence Grade ≥ 2) underwent three-dimensional gait analysis...
March 2018: Gait & Posture
https://www.readbyqxmd.com/read/29462464/determining-brain-mechanisms-that-underpin-analgesia-induced-by-the-use-of-pain-coping-skills
#7
Leonie J Cole, Kim L Bennell, Yasmin Ahamed, Christina Bryant, Francis Keefe, G Lorimer Moseley, Paul Hodges, Michael J Farrell
Objective: Cognitive behavioral therapies decrease pain and improve mood and function in people with osteoarthritis. This study assessed the effects of coping strategies on the central processing of knee pain in people with osteoarthritis of the knees. Methods: Mechanical pressure was applied to exacerbate knee pain in 28 people with osteoarthritis of the knee. Reports of pain intensity and functional magnetic resonance imaging measures of pain-related brain activity were recorded with and without the concurrent use of pain coping skills...
February 16, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29460011/issls-prize-in-clinical-science-2018-longitudinal-analysis-of-inflammatory-psychological-and-sleep-related-factors-following-an-acute-low-back-pain-episode-the-good-the-bad-and-the-ugly
#8
David M Klyne, Mary F Barbe, Wolbert van den Hoorn, Paul W Hodges
STUDY DESIGN: Prospective longitudinal study. OBJECTIVE: To determine whether systemic cytokines and C-reactive protein (CRP) during an acute episode of low back pain (LBP) differ between individuals who did and did not recover by 6 months and to identify sub-groups based on patterns of inflammatory, psychological, and sleep features associated with recovery/non-recovery. Systemic inflammation is observed in chronic LBP and may contribute to the transition from acute to persistent LBP...
February 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29432721/vastus-lateralis-motor-unit-firing-rate-is-higher-in-females-with-patellofemoral-pain
#9
Alessio Gallina, Michael A Hunt, Paul Hodges, S Jayne Garland
OBJECTIVE: To compare neural drive, determined from motor unit firing rate, to the vastus medialis and lateralis in females with and without patellofemoral pain. DESIGN: Cross-sectional study. SETTING: University research laboratory. PARTICIPANTS: Females (N=56) 19-35 years old, 36 with patellofemoral pain and 20 controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE(S): Participants sustained an isometric knee extension contraction at 10% of their maximal voluntary effort for 70s...
February 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29399393/pd-1-blockade-reverses-adaptive-immune-resistance-induced-by-high-dose-hypofractionated-but-not-low-dose-daily-fractionated-radiation
#10
Megan Morisada, Paul E Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W Hodge, James B Mitchell, Jay Friedman, Clint T Allen
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck squamous cell carcinoma results in lymphopenia and may be immunosuppressive. We compared immune correlates, primary tumor and abscopal tumor control rates following the addition of PD-1 mAb to either high-dose hypofractioned (8Gyx2) or low-dose daily fractionated (2Gyx10) IR in syngeneic models of cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29395230/effects-of-intervertebral-disc-lesion-and-multifidus-muscle-resection-on-the-structure-of-the-lumbar-intervertebral-discs-and-paraspinal-musculature-of-the-rat
#11
Huub Maas, Wendy Noort, Paul W Hodges, Jaap van Dieën
The aim of this study was to investigate whether elimination of multifidus muscle in rats causes intervertebral disc (IVD) degeneration similar to that found after IVD lesion. Data were obtained from 36 male Wistar rats randomly assigned to one of three groups: (i) IVD lesion, in which the L4/L5 IVD was stabbed; (ii) multifidus muscle resection, in which all multifidus tissue between L3 and L6 was excised bilaterally; (iii) control, in which no intervention was applied. At 7, 14, and 28 days post-intervention, L4/L5 IVDs were harvested for histological analysis; left and right multifidus fascicles between L3 and S1 (from control and IVD lesion animals) and medial longissimus between L1 and S3 (from all animals) were dissected and weighed...
January 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29383498/episodic-bouts-of-hyperaemia-and-shear-stress-improve-arterial-blood-flow-and-endothelial-function
#12
Gary J Hodges, Desmond G Stewart, Paul J Davison, Stephen S Cheung
INTRODUCTION: Exercise and heat stress lead to systemic improvements in arterial endothelial function, vascular stiffness, and cardiopulmonary capacity. The improvements in endothelial function may be primarily mediated via increases in shear stress. This study examined whether improvements in arterial function may be achieved in the absence of systemic vascular adaptations. Specifically, we hypothesized that repeated bouts of brief occlusion would improve arterial endothelial function via shear stress-dependent mechanisms...
January 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29364067/effect-of-experimental-muscle-pain-on-the-acquisition-and-retention-of-locomotor-adaptation-different-motor-strategies-for-a-similar-performance
#13
Jason Bouffard, Sauro Emerick Salomoni, Catherine Mercier, Kylie J Tucker, Jean-Sebastien Roy, Wolbert van den Hoorn, Paul W Hodges, Laurent J Bouyer
BACKGROUND: As individuals with musculoskeletal disorders often experience motor impairments, contemporary rehabilitation relies heavily on the use of motor learning principles. However, motor impairments are often associated with pain. While there is substantial evidence that muscle pain interferes with motor control, much less is known on its impact on motor learning, especially on locomotor learning. The objective of the present study was to assess the effects of muscle pain on locomotor learning...
January 24, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29353742/trunk-pelvis-and-hip-biomechanics-in-individuals-with-femoroacetabular-impingement-syndrome-strategies-for-step-ascent
#14
Laura E Diamond, Kim L Bennell, Tim V Wrigley, Rana S Hinman, Michelle Hall, John O'Donnell, Paul W Hodges
BACKGROUND: Femoroacetabular impingment (FAI) syndrome is common among young active adults and a proposed risk factor for the future development of hip osteoarthritis. Pain is dominant and drives clinical decision-making. Evidence for altered hip joint function in this patient population is inconsistent, making the identification of treatment targets challenging. A broader assessment, considering adjacent body segments (i.e. pelvis, trunk) and individual movement strategies, may better inform treatment programs...
March 2018: Gait & Posture
https://www.readbyqxmd.com/read/29353149/different-ways-to-balance-the-spine-in-sitting-muscle-activity-in-specific-postures-differs-between-individuals-with-and-without-a-history-of-back-pain-in-sitting
#15
Andrew P Claus, Julie A Hides, G Lorimer Moseley, Paul W Hodges
BACKGROUND: Previous research explored muscle activity in four distinct sitting postures with fine-wire electromyography, and found that lumbar multifidus muscle activity increased incrementally between sitting with flat thoracolumbar and lumbar regions, long thoracolumbar lordosis, or short lordosis confined to the lumbar region. This study used similar methods to explore whether people with a history of low back pain provoked by prolonged sitting used different patterns of trunk muscle activity in specific postures...
February 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29352737/bronchiolitis-obliterans-syndrome-is-associated-with-increased-p-glycoprotein-expression-and-loss-of-glucocorticoid-receptor-from-steroid-resistant-proinflammatory-cd8-t-cells
#16
G Hodge, S Hodge, P T Nguyen, A Yeo, P Sarkar, A Badiei, C L Holmes-Liew, P N Reynolds, M Holmes
Immunosuppressive therapy fails to suppress the production of proinflammatory cytokines, particularly by CD8+ T cells, in stable lung transplant recipients and those undergoing chronic rejection, suggesting that some patients may become relatively resistant to immunosuppressants such as glucocorticoids (GC). We have shown loss of GC receptor (GCR) from the CD8+ cells, and we hypothesized that the drug membrane efflux pump, p-glycoprotein-1 (Pgp), may also be involved in lymphocyte steroid resistance following lung transplant...
May 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29323299/rotation-in-c-ii-emitting-gas-in-two-galaxies-at-a-redshift-of-6-8
#17
Renske Smit, Rychard J Bouwens, Stefano Carniani, Pascal A Oesch, Ivo Labbé, Garth D Illingworth, Paul van der Werf, Larry D Bradley, Valentino Gonzalez, Jacqueline A Hodge, Benne W Holwerda, Roberto Maiolino, Wei Zheng
The earliest galaxies are thought to have emerged during the first billion years of cosmic history, initiating the ionization of the neutral hydrogen that pervaded the Universe at this time. Studying this 'epoch of reionization' involves looking for the spectral signatures of ancient galaxies that are, owing to the expansion of the Universe, now very distant from Earth and therefore exhibit large redshifts. However, finding these spectral fingerprints is challenging. One spectral characteristic of ancient and distant galaxies is strong hydrogen-emission lines (known as Lyman-α lines), but the neutral intergalactic medium that was present early in the epoch of reionization scatters such Lyman-α photons...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29321191/mortality-after-magnetic-resonance-imaging-of-the-brain-in-patients-with-cardiovascular-implantable-devices
#18
Deepak Padmanabhan, Mary L Jondal, David O Hodge, Ramila A Mehta, Nancy G Acker, Connie M Dalzell, Suraj Kapa, Samuel J Asirvatham, Yong-Mei Cha, Joel P Felmlee, Robert E Watson, Paul A Friedman
BACKGROUND: Use of magnetic resonance imaging (MRI) brain is restricted in patients with cardiovascular implantable electronic devices (CIEDs). We proposed to determine whether mortality difference exists for patients with non-MRI-conditional CIEDs undergoing brain MRI compared with controls. METHODS AND RESULTS: Retrospective analysis of prospectively collected data was performed to compare all-cause mortality in patients with CIEDs undergoing brain MRI (CIED-MRI) with 3 control groups matched for age, sex, imaging year, and type of CIED: (1) no CIED, brain MRI (no-CIED-MRI); (2) CIED, brain computerized tomography (CT) scan (CIED-CT); and (3) no CIED, brain CT (no-CIED-CT)...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29238985/impaired-functional-vitamin-b6-status-is-associated-with-increased-risk-of-lung-cancer
#19
Despoina Theofylaktopoulou, Øivind Midttun, Per M Ueland, Klaus Meyer, Anouar Fanidi, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang, Ross Prentice, Mary Pettinger, Cynthia A Thomson, Graham G Giles, Allison Hodge, Qiuyin Cai, William J Blot, Jie Wu, Mikael Johansson, Johan Hultdin, Kjell Grankvist, Victoria L Stevens, Marjorie M McCullough, Stephanie J Weinstein, Demetrius Albanes, Regina Ziegler, Neal D Freedman, Arnulf Langhammer, Kristian Hveem, Marit Naess, Howard D Sesso, J Michael Gaziano, Julie E Buring, I-Min Lee, Gianluca Severi, Xuehong Zhang, Meir J Stampfer, Jiali Han, Stephanie A Smith-Warner, Anne Zeleniuch-Jacquotte, Loic Le Marchand, Jian-Min Yuan, Renwei Wang, Lesley M Butler, Woon-Puay Koh, Yu-Tang Gao, Nathaniel Rothman, Ulrika Ericson, Emily Sonestedt, Kala Visvanathan, Miranda R Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Arve Ulvik
Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3)...
December 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29149847/individuals-explanations-for-their-persistent-or-recurrent-low-back-pain-a-cross-sectional-survey
#20
Jenny Setchell, Nathalia Costa, Manuela Ferreira, Joanna Makovey, Mandy Nielsen, Paul W Hodges
BACKGROUND: Most people experience low back pain (LBP), and it is often ongoing or recurrent. Contemporary research knowledge indicates individual's pain beliefs have a strong effect on their pain experience and management. This study's primary aim was to determine the discourses (patterns of thinking) underlying people's beliefs about what causes their LBP to persist. The secondary aim was to investigate what they believed was the source of this thinking. METHODS: We used a primarily qualitative survey design: 130 participants answered questions about what caused their LBP to persist, and where they learned about these causes...
November 17, 2017: BMC Musculoskeletal Disorders
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