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https://www.readbyqxmd.com/read/29775119/effects-of-exercise-in-combination-with-autologous-bone-marrow-stem-cell-transplantation-for-patients-with-type-1-diabetes
#1
Marwa Taher Mohamed, Eman Ahmed Embaby, Awatif Labib, Mohammed El-Husseiny, Hazem Khamis, Ahmed El-Demery, Mohamed Mounir Shoukry
Stem cell therapy is a promising approach for the treatment of type 1 diabetes mellitus (T1D). Previous studies recommended regular exercise for the control of T1D. Experimental studies showed that a combination of stem cells and exercise yielded a better outcome. Yet, the effect of exercise programs following stem cell transplantation in patients with T1D has not been investigated. Thus, the current study aimed to examine the effect of a combined exercise program on measures of glycemic control in patients with T1D who received autologous bone marrow stem cell transplantation (ABMSCT)...
May 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29626665/ethiopian-highlands-as-a-cradle-of-the-african-fossorial-root-rats-genus-tachyoryctes-the-genetic-evidence
#2
Radim Šumbera, Jarmila Krásová, Leonid A Lavrenchenko, Sewnet Mengistu, Afework Bekele, Ondřej Mikula, Josef Bryja
Root-rats of the genus Tachyoryctes (Spalacidae) are subterranean herbivores occupying open humid habitats in the highlands of Eastern Africa. There is strong disagreement about species diversity of the genus, because some authors accept two species, while others more than ten. Species with relatively high surface activity, the giant root-rat Tachyoryctes macrocephalus, which is by far largest member of the genus, and the more fossorial African root-rat Tachyoryctes splendens, which eventually has been divided up to 12-13 species, represent two major morphological forms within the genus...
April 4, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29495861/ion-temperature-measurements-of-indirect-drive-implosions-with-the-neutron-time-of-flight-detector-on-sg-iii-laser-facility
#3
Zhongjing Chen, Xing Zhang, Yudong Pu, Ji Yan, Tianxuan Huang, Wei Jiang, Bo Yu, Bolun Chen, Qi Tang, Zifeng Song, Jiabin Chen, Xiayu Zhan, Zhongjie Liu, Xufei Xie, Shaoen Jiang, Shenye Liu
The accuracy of the determination of the burn-averaged ion temperature of inertial confinement fusion implosions depends on the unfold process, including deconvolution and convolution methods, and the function, i.e., the detector response, used to fit the signals measured by neutron time-of-flight (nToF) detectors. The function given by Murphy et al. [Rev. Sci. Instrum. 68(1), 610-613 (1997)] has been widely used in Nova, Omega, and NIF. There are two components, i.e., fast and slow, and the contribution of scattered neutrons has not been dedicatedly considered...
February 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29318244/metabolic-fate-of-strawberry-polyphenols-after-chronic-intake-in-healthy-older-adults
#4
Amandeep K Sandhu, Marshall G Miller, Nopporn Thangthaeng, Tammy M Scott, Barbara Shukitt-Hale, Indika Edirisinghe, Britt Burton-Freeman
Strawberries contain a wide array of nutrients and phytochemicals including polyphenols such as anthocyanins, proanthocyanidins and ellagitannins. These polyphenols are absorbed and metabolized to various phenolic metabolites/conjugates in the body, which may play a role in disease risk reduction. In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d-1 , equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults...
January 24, 2018: Food & Function
https://www.readbyqxmd.com/read/29274761/spatial-integration-during-performance-in-pigeons
#5
Aaron P Blaisdell, Julia E Schroeder, Cynthia D Fast
We've shown that pigeons can integrate separately acquired spatial maps into a cognitive map. Integration requires an element shared between maps. In two experiments using a spatial-search task in pigeons, we test spatial combination rules when no shared element was present during training. In all three experiments, pigeons first learned individual landmark-target maps. In subsequent tests involving combinations of landmarks, we found evidence that landmarks collaborate in guiding spatial choice at test (Experiment 1)...
December 21, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29233823/large-cardiac-muscle-patches-engineered-from-human-induced-pluripotent-stem-cell-derived-cardiac-cells-improve-recovery-from-myocardial-infarction-in-swine
#6
Ling Gao, Zachery R Gregorich, Wuqiang Zhu, Saidulu Mattapally, Yasin Oduk, Xi Lou, Ramaswamy Kannappan, Anton V Borovjagin, Gregory P Walcott, Andrew E Pollard, Vladimir G Fast, Xinyang Hu, Steven G Lloyd, Ying Ge, Jianyi Zhang
Background -Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth-muscle cells, and endothelial cells that had been differentiated from human induced-pluripotent stem cells (hiPSCs) in a fibrin scaffold and then culturing the construct on a dynamic (rocking) platform. Methods - In vitro assessments of hCMPs suggest maturation in response to dynamic culture stimulation. In vivo assessments were conducted in a porcine model of myocardial infarction (MI)...
December 12, 2017: Circulation
https://www.readbyqxmd.com/read/29231227/viscoelastic-behaviour-and-relaxation-modes-of-one-polyamic-acid-organogel-studied-by-rheometers-and-dynamic-light-scattering
#7
Ensong Zhang, Yong Zhao, Wenke Yang, Hongxiang Chen, Wei Liu, Xuemin Dai, Xuepeng Qiu, Xiangling Ji
A novel polyamic acid (PAA from BAPMPO-BPDA) organogel was synthesized and characterized via dynamic light scattering (DLS), a classical rheometer, and diffusion wave spectroscopy (DWS). In situ monitoring was performed using a classical rheometer to observe the formation of the PAA organogel. The rheological curves confirm the formation of the PAA gel network and the origin of hydrogen bonding from the -NH- group (donor) and P[double bond, length as m-dash]O group (acceptor). The autocorrelation functions of PAA under different conditions (pure gel, gel with NaNO3 , gel with formamide) are measured via DLS, and different characteristic times are obtained via the CONTIN method...
December 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/29146418/diagnostic-accuracy-of-the-extended-focused-abdominal-sonography-for-trauma-e-fast-performed-by-emergency-physicians-compared-to-computed-tomography
#8
Haldun Akoglu, Omer Faruk Celik, Ali Celik, Rabia Ergelen, Ozge Onur, Arzu Denizbasi
INTRODUCTION: The diagnostic accuracy of the FAST exam performed by EM residents were shown to be similar to radiology residents. However, in the last 2 decades, an extended-FAST (E-FAST) protocol including thoracic examination to exclude pneumo- and hemothorax was introduced. The accuracy of emergency physicians (EPs) while performing E-FAST is a less studied area, especially in Europe. The aim of this study was to compare the diagnostic accuracy of the E-FAST exam performed by EM residents with the results of CT scan as a gold standard...
November 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29125636/very-tight-vs-tight-control-what-should-be-the-criteria-for-pharmacologic-therapy-dose-adjustment-in-diabetes-in-pregnancy-evidence-from-randomized-controlled-trials
#9
REVIEW
Claudia Caissutti, Gabriele Saccone, Andrea Ciardulli, Vincenzo Berghella
INTRODUCTION: There is inconclusive evidence from randomized controlled trials (RCTs) to support any specific criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy. Our objective was to analyze the criteria for dose adjustment of pharmacologic treatment for diabetes mellitus (DM) in pregnancy. MATERIAL AND METHODS: Data sources: MEDLINE, OVID and Cochrane Library were searched from their inception to September 2017. Selection criteria included all trials of DM in pregnancy managed by oral hypoglycemic agents or insulin reporting criteria for pharmacologic therapy dose adjustment...
March 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29062231/positive-end-expiratory-pressure-attenuates-hemodynamic-effects-induced-by-an-overload-of-inspiratory-muscles-in-patients-with-copd
#10
Flavia Schaper-Magalhães, José Felippe Pinho, Carolina Andrade Bragança Capuruço, Maria Glória Rodrigues-Machado
BACKGROUND: Inspiratory muscle training (IMT) using a Threshold® device is commonly used to improve the strength and endurance of inspiratory muscles. However, the effect of IMT, alone or with positive end-expiratory pressure (PEEP), on hemodynamic parameters in patients with chronic obstructive pulmonary disease (COPD) remains unknown. OBJECTIVE: To assess the effects of an overload of inspiratory muscles using IMT fixed at 30% of the maximal inspiratory pressure (MIP), and IMT associated with 5 cmH2 O of PEEP (IMT + PEEP), on the echocardiographic parameters in healthy subjects and patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28804466/interpersonal-movement-synchrony-responds-to-high-and-low-level-conversational-constraints
#11
Alexandra Paxton, Rick Dale
Much work on communication and joint action conceptualizes interaction as a dynamical system. Under this view, dynamic properties of interaction should be shaped by the context in which the interaction is taking place. Here we explore interpersonal movement coordination or synchrony-the degree to which individuals move in similar ways over time-as one such context-sensitive property. Studies of coordination have typically investigated how these dynamics are influenced by either high-level constraints (i.e., slow-changing factors) or low-level constraints (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28690568/fat-content-modulates-rapid-detection-of-food-a-visual-search-study-using-fast-food-and-japanese-diet
#12
Reiko Sawada, Wataru Sato, Motomi Toichi, Tohru Fushiki
Rapid detection of food is crucial for the survival of organisms. However, previous visual search studies have reported discrepant results regarding the detection speeds for food vs. non-food items; some experiments showed faster detection of food than non-food, whereas others reported null findings concerning any speed advantage for the detection of food vs. non-food. Moreover, although some previous studies showed that fat content can affect visual attention for food, the effect of fat content on the detection of food remains unclear...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28648696/integrating-behaviour-into-the-pace-of-life-continuum-divergent-levels-of-activity-and-information-gathering-in-fast-and-slow-living-snakes
#13
Eric J Gangloff, Melinda Chow, Vianey Leos-Barajas, Stephanie Hynes, Brooke Hobbs, Amanda M Sparkman
An animal's life history, physiology, and behaviour can be shaped by selection in a manner that favours strong associations among these aspects of an integrated phenotype. Recent work combining animal personality and life-history theory proposes that animals with faster life-history strategies (i.e., fast growth, high annual reproductive rate, short lifespan) should exhibit higher general activity levels relative to those with slower life-history strategies, but empirical tests of within-species variation in these traits are lacking...
September 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28631802/aqueous-tantalum-polyoxometalate-reactivity-with-peroxide
#14
Lauren B Fullmer, Christopher E Malmberg, Dylan B Fast, Lindsay A Wills, Paul Ha-Yeon Cheong, Michelle R Dolgos, May Nyman
Peroxide ligation of aqueous metal-oxo clusters provides rich speciation and structural diversity, radiation sensitivity for manipulation with light, and both broadens and shifts pH-range stability. Here we demonstrate peroxide ligation of the polyoxometalate (POM) [Ta6 O19 ]8- . We study in detail solution speciation of the peroxide-substituted cluster, and benchmark it to the peroxide-ligated niobate analogue, [Nb6 O10 (OH)3 (O2 )6 ]5- , whose solid-state structure has been reported. Raman and electrospray ionization mass spectroscopy do not detect any significant differences between the two analogues...
July 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28465592/gene-co-expression-network-analysis-identifies-porcine-genes-associated-with-variation-in-metabolizing-fenbendazole-and-flunixin-meglumine-in-the-liver
#15
Jeremy T Howard, Melissa S Ashwell, Ronald E Baynes, James D Brooks, James L Yeatts, Christian Maltecca
Identifying individual genetic variation in drug metabolism pathways is of importance not only in livestock, but also in humans in order to provide the ultimate goal of giving the right drug at the right dose at the right time. Our objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver. The population consisted of female and castrated male pigs that were sired by boars represented by 4 breeds. Progeny were randomly placed into groups: no drug (UNT), FLU or FBZ administered...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416629/individual-differences-in-fear-extinction-and-anxiety-like-behavior
#16
Gabrielle King, Elliot Scott, Bronwyn M Graham, Rick Richardson
There is growing appreciation for the substantial individual differences in the acquisition and inhibition of aversive associations, and the insights this might give into identifying individuals particularly vulnerable to stress and psychopathology. We examined whether animals that differed in rate of extinction (i.e., Fast versus Slow) were different in their response to an acute stress in adulthood or following a chronic stress that occurred either early or later in life. We found that Slow Extinguishers had significantly poorer extinction retention than Fast Extinguishers, but an acute stressor did not differentially affect anxiety-like behavior in the two groups...
May 2017: Learning & Memory
https://www.readbyqxmd.com/read/28315251/fpps-fast-profiling-of-protease-specificity
#17
Matej Vizovišek, Robert Vidmar, Marko Fonović
Profiling of protease specificity is crucial for characterization of these important enzymes that play numerous roles in health and disease. In the past, several proteomic methods have been developed that enable profiling of protease specificities. Although able to identify thousands of protease cleavage events, these degradomics approaches are often time consuming and methodologically challenging, which limits their application to specialized proteomic groups or the laboratories that initially introduced them...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28263560/compressible-dense-three-dimensional-holey-graphene-monolithic-architecture
#18
Xiaogang Han, Zhi Yang, Bin Zhao, Shuze Zhu, Lihui Zhou, Jiaqi Dai, Jae-Woo Kim, Boyang Liu, John W Connell, Teng Li, Bao Yang, Yi Lin, Liangbing Hu
By creating holes in 2D nanosheets, tortuosity and porosity can be greatly tunable, which enables a fast manufacturing process (i.e., fast removal of gas and solvent) toward various nanostructures. We demonstrated outstanding compressibility of holey graphene nanosheets, which is impossible for pristine graphene. Holey graphene powder can be easily compressed into dense and strong monoliths with different shapes at room temperature without using any solvents or binders. The remarkable compressibility of holey graphene, which is in sharp contrast with pristine graphene, not only enables the fabrication of robust, dense graphene products that exhibit high density (1...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28153011/association-between-caregivers-knowledge-and-care-seeking-behaviour-for-children-with-symptoms-of-pneumonia-in-six-sub-saharan-african-countries
#19
Aaltje Camielle Noordam, Alyssa B Sharkey, Paddy Hinssen, GeertJan Dinant, Jochen W L Cals
BACKGROUND: Pneumonia is the main cause of child mortality world-wide and most of these deaths occur in sub-Saharan Africa (SSA). Treatment with effective antibiotics is crucial to prevent these deaths; nevertheless only 2 out of 5 children with symptoms of pneumonia are taken to an appropriate care provider in SSA. While various factors associated with care seeking have been identified, the relationship between caregivers' knowledge of pneumonia symptoms and actual care seeking for their child with symptoms of pneumonia is not well researched...
February 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28097510/when-headache-warns-of-homeostatic-threat-the-metabolic-headaches
#20
REVIEW
Parneet Grewal, Jonathan H Smith
Headache attributable to disorders of homeostasis represents a diverse diagnostic category in which external (i.e., high-altitude) or internal (i.e., fasting) demands exceed homeostatic capacity, resulting in symptomatic headaches. Metabolic headaches, especially fasting headache, have been observed to be common in the general population. In many cases, a history of migraine is a risk factor, consistent with the hypothesis of an adaptive, evolutionary role of headache to warn against environmental and physiological threats...
January 2017: Current Neurology and Neuroscience Reports
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