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Tze Ping Loh, Stefan Ma, Derrick Heng, Chin Meng Khoo
We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/ residential dwelling type stratification, followed up ethnicity. 2,407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis...
2016: PloS One
Susanna Calling, Xinjun Li, Naomi Kawakami, Tsuyoshi Hamano, Kristina Sundquist
BACKGROUND: Living in a socially deprived neighborhood is associated with lifestyle risk factors, e.g., smoking, physical inactivity and unhealthy diet, as well as an increased risk of cardiovascular disease, i.e., coronary heart disease and stroke. The aim was to study whether the odds of cardiovascular disease vary with the neighbourhood availability of potentially health-damaging and health-promoting resources. METHODS: A nationwide sample of 2 040 826 men and 2 153 426 women aged 35-80 years were followed for six years for first hospitalization of coronary heart disease or stroke...
2016: BMC Public Health
Kevin van Schie, Suzanne C van Veen, Iris M Engelhard, Irene Klugkist, Marcel A van den Hout
BACKGROUND: In eye movement desensitization and reprocessing (EMDR), patients make eye movements (EM) while recalling traumatic memories. Making EM taxes working memory (WM), which leaves less resources available for imagery of the memory. This reduces memory vividness and emotionality during future recalls. WM theory predicts that individuals with small working memory capacities (WMCs) benefit more from low levels of taxing (i.e., slow EM) whereas individuals with large WMC benefit more from high levels of taxing (i...
2016: European Journal of Psychotraumatology
Richard C Sadler, Andrew F Clark, Piotr Wilk, Colleen O'Connor, Jason A Gilliland
OBJECTIVES: This study examines the influence of adolescents' exposure to unhealthy food outlets on junk food purchasing during trips between home and school, with particular attention to how exposure and purchasing differ according to child's biological sex, mode of transportation, and direction to or from school. METHODS: Between 2010 and 2013, students (n = 654) aged 9-13 years from 25 schools in London and Middlesex County, ON, completed a socio-demographic survey and an activity diary (to identify food purchases), and were observed via a global positioning system for 2 weeks (to track routes for trips to/from school)...
2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Hamidur Rahman, Mobyen Uddin Ahmed, Shahina Begum
Research progressing during the last decade focuses more on non-contact based systems to monitor Heart Rate (HR) which are simple, low-cost and comfortable to use. Most of the non-contact based systems are using RGB videos which is suitable for lab environment. However, it needs to progress considerably before they can be applied in real life applications. As luminance (light) has significance contribution on RGB videos HR monitoring using RGB videos are not efficient enough in real life applications in outdoor environment...
2016: Studies in Health Technology and Informatics
Shuangni Zhao, Le Van Minh, Na Li, Vasil M Garamus, Ulrich A Handge, Jianwen Liu, Rongguang Zhang, Regine Willumeit-Römer, Aihua Zou
The hydrophilic drug Doxorubicin hydrochloride (DOX) paired with oleic acid (OA) was successfully incorporated into nanostructured lipid carriers (NLCs) by a high-pressure homogenization (HPH) method. Drug nanovehicles with proper physico-chemical characteristics (less than 200nm with narrow size distribution, spherical shape, layered internal organization, and negative electrical charge) were prepared and characterized by dynamic light scattering, zeta potential measurements, transmission electron microscopy, small-angle X-ray scattering and differential scanning calorimetry...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
Jessica Fuhrmeister, Annika Zota, Tjeerd P Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G Okun, Stephan Herzig, Adam J Rose
Recent studies have demonstrated that repeated short-term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we show that, metabolic control, particularly systemic and liver lipid metabolism, is aberrantly regulated in the fasted state in mouse models of metabolic dysfunction. Liver transcript assays between lean/healthy and obese/diabetic mice in fasted and fed states uncovered "growth arrest and DNA damage-inducible" GADD45β as a dysregulated gene transcript during fasting in several models of metabolic dysfunction including ageing, obesity/pre-diabetes and type 2 diabetes, in both mice and humans...
2016: EMBO Molecular Medicine
Giovanni Bellanova, Francesco Buccelletti, Riccardo Berletti, Marco Cavana, Giorgio Folgheraiter, Francesca Groppo, Chiara Marchetti, Amelia Marzano, Alessandro Massè, Antonio Musetti, Tina Pelanda, Nicola Ricci, Gregorio Tugnoli, Damiano Papadia, Claudio Ramponi
AIM: Aim of this study is to analyze how the starting of Course of Trauma in our hospital improved survival and organization in management of polytraumatized patients. MATERIAL OF STUDY: We analysed all major trauma patients (Injury Severity Score (Injury Severity Score (ISS)> 15) treated at Emergency Department of the Santa Chiara Hospital between January 2011 and December 2014. The training courses (TC) were named "management of polytrauma" (MP) and "clinical cases discussion" (CCD), and started in November 2013...
2016: Annali Italiani di Chirurgia
Qiuying Han, Laura M Soissons, Tjeerd J Bouma, Marieke M van Katwijk, Dongyan Liu
Excess nutrients are potential factors that drive phase shifts from seagrasses to macroalgae. We carried out a manipulative field experiment to study the effects of macroalgae Ulva pertusa loading and nutrient addition to the water column on the nitrogen (N) and carbon (C) contents (i.e., fast indicators) as well as on the morphology and structure (i.e., slow indicators) of Zostera marina. Our results showed rapid impact of increased macroalgae and nutrient load on Z. marina C/N ratios. Also, macroalgae addition resulted in a trend of decreasing belowground biomass of seagrasses, and nutrient load significantly decreased above to belowground biomass ratio...
May 15, 2016: Marine Pollution Bulletin
Tengfei Wang, Hany E Marei
PURPOSE: The prevalence of phenotypes of Arylamine N-acetyltransferase-2(NAT2) gene (i.e. fast, intermediate and slow acetylators) among ethnic groups, as well as the association studies regarding NAT2 polymorphisms and risk of breast cancer produced inconsistent results. This meta-analysis aimed to clarify whether the selected NAT2 phenotypes have an effect on the susceptibility to breast cancer. METHODS: After aggregating the frequencies of fast, intermediate and slow phenotypes of NAT2 in breast cancer subjects, the odds ratio and relevant 95% confidence intervals were examined using combined data from all published 36 articles...
February 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
M Zanobetti, A Coppa, P Nazerian, S Grifoni, M Scorpiniti, F Innocenti, A Conti, S Bigiarini, S Gualtieri, C Casula, P F Ticali, R Pini
PURPOSE: To evaluate the feasibility of a new protocol, Chest Abdominal-Focused Assessment Sonography for Trauma (CA-FAST), during the primary survey and to estimate its diagnostic accuracy when compared with thoracoabdominal computed tomography (CT) scan. METHODS: A prospective accuracy study was performed from November 2012 to November 2013 at the Emergency Department. Only adult trauma patients who underwent a CA-FAST examination prior to a thoracoabdominal CT scan were enrolled...
December 18, 2015: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Marko Pavlovic, Monika Adok-Sipiczki, Corinne Nardin, Samuel Pearson, Elodie Bourgeat-Lami, Vanessa Prevot, Istvan Szilagyi
The colloidal behavior of layered double hydroxide nanoparticles containing Mg(2+) and Al(3+) ions as intralayer cations and nitrates as counterions (MgAl-NO3-LDH) was studied in the presence of a short statistical copolymer of acrylic acid (AA) and butyl acrylate (BA) terminated with 4-cyano-4-thiothiopropylsulfanyl pentanoic acid (CTPPA) (P(AA7.5-stat-BA7.5)-CTPPA) synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization. Surface charge properties and aggregation of the particles were investigated by electrophoresis and dynamic light scattering (DLS), respectively...
November 24, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
Christopher W Resnyk, Chuming Chen, Hongzhan Huang, Cathy H Wu, Jean Simon, Elisabeth Le Bihan-Duval, Michel J Duclos, Larry A Cogburn
Genetic selection for enhanced growth rate in meat-type chickens (Gallus domesticus) is usually accompanied by excessive adiposity, which has negative impacts on both feed efficiency and carcass quality. Enhanced visceral fatness and several unique features of avian metabolism (i.e., fasting hyperglycemia and insulin insensitivity) mimic overt symptoms of obesity and related metabolic disorders in humans. Elucidation of the genetic and endocrine factors that contribute to excessive visceral fatness in chickens could also advance our understanding of human metabolic diseases...
2015: PloS One
K L Koslov, A N Shishkevich, V N Kravchuk, S S Mikhaĭlov, E A Kniazev, I B Oleksiuk
Hybrid revasculization of myocardium combined the advantages of mammary-coronary bypass surgery and coronary arteries stenting. It presented itself as a perspective direction in treatment of ischemic coronary disease. The article provides the results of comparison of usage of hybrid revasculization of myocardium and aortocoronary bypass in 71 patients with multivessel coronary artery disease. The data obtained indicated, that hybrid approach allowed complete revasculization of the myocardium (as in case of aortocoronary bypass), fast recovery of the patient, shortening a hospital stay due to decrease of intra- and postoperative complications...
2015: Vestnik Khirurgii Imeni I. I. Grekova
Longsheng Zhang, Qianwei Ding, Yunpeng Huang, Huahao Gu, Yue-E Miao, Tianxi Liu
The practical applications of transition metal oxides and hydroxides for supercapacitors are restricted by their intrinsic poor conductivity, large volumetric expansion, and rapid capacitance fading upon cycling, which can be solved by optimizing these materials to nanostructures and confining them within conductive carbonaceous frameworks. In this work, flexible hybrid membranes with ultrathin Ni(OH)2 nanoplatelets vertically and uniformly anchored on the electrospun carbon nanofibers (CNF) have been facilely prepared as electrode materials for supercapacitors...
October 14, 2015: ACS Applied Materials & Interfaces
Nicolas Lepareur, Loleh Leal E Costa, Maëva Bocqué, Clément Blondelle, Clément Ruello, Marie Desjulets, Nicolas Noiret, Sandrine Cammas-Marion
INTRODUCTION: Encapsulation of biologically active molecules into nanoparticles (NPs), for site-specific delivery, is a fast growing area. These NPs must be biocompatible, non-toxic, and able to release their load in a controlled way. We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted stealth analog and target-specific biotin-PEG-b-PMLABe one. A lipophilic radiotracer has then been encapsulated into these NPs...
2015: Frontiers in Medicine
Gary W Witmer, Nathan P Snow, Rachael S Moulton
Invasive American bullfrogs [Rana catesbeiana (Lithobates catesbeianus)] are outcompeting and predating on native biota and contributing to reductions in biodiversity worldwide. Current methods for controlling American bullfrogs are incapable of stopping their expansion, thus more cost-effective and broadly applicable methods are needed. Although chemical control compounds have been identified as effective for removing other invasive amphibians, none have been tested for American bullfrogs. Our objective was to expand on previous research and test the efficacy of 10 potential chemical control compounds for removing invasive American bullfrogs...
2015: SpringerPlus
Josje M de Valk, Jasper G Wijnen, Mariska E Kret
Efficiently responding to others' emotions, especially threatening expressions such as anger and fear, can have great survival value. Previous research has shown that humans have a bias toward threatening stimuli. Most of these studies focused on facial expressions, yet emotions are expressed by the whole body, and not just by the face. Body language contains a direct action component, and activates action preparation areas in the brain more than facial expressions. Hence, biases toward threat may be larger following threatening bodily expressions as compared to facial expressions...
2015: Frontiers in Psychology
Jun Chen, Jing Shen, Lars Ingvar Hellgren, Peter Ruhdal Jensen, Christian Solem
Lactococcus lactis is essential for most cheese making, and this mesophilic bacterium has its growth optimum around 30 °C. We have, through adaptive evolution, isolated a mutant TM29 that grows well up to 39 °C, and continuous growth at 40 °C is possible if pre-incubated at a slightly lower temperature. At the maximal permissive temperature for the wild-type, 38 °C, TM29 grows 33% faster and has a 12% higher specific lactate production rate than its parent MG1363, which results in fast lactate accumulation...
2015: Scientific Reports
G R Tundo, D Sbardella, C Ciaccio, S De Pascali, V Campanella, P Cozza, U Tarantino, M Coletta, F P Fanizzi, S Marini
Cisplatin is a widely used chemotherapy drug which exerts cytotoxic activity by affecting both nuclear and cytosolic pathways. Herewith, we report, for the first time, that cisplatin inhibits proteasome activity in vitro. Cisplatin induces a dose dependent inhibition of the three enzymatic activities of proteasome (i.e., the chymotrypsin-like activity, the trypsin-like activity and the caspase-like activity). Moreover, cisplatin administration to neuroblastoma cells brings about a fast loss of proteasome particle activity, which is followed by a de novo synthesis of proteasome...
December 2015: Journal of Inorganic Biochemistry
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