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https://www.readbyqxmd.com/read/29221952/danshensu-prevents-hypoxic-pulmonary-hypertension-in-rats-by-inhibiting-the-proliferation-of-pulmonary-artery-smooth-muscle-cells-via-tgf-%C3%AE-smad3-associated-pathway
#1
Ning Zhang, Mingqing Dong, Ying Luo, Feng Zhao, Yongjun Li
Hypoxic pulmonary hypertension is characterized by the remodeling of pulmonary artery. Previously we showed that tanshinone IIA, one lipid-soluble component from the Chinese herb Danshen, ameliorated hypoxic pulmonary hypertension by inhibiting pulmonary artery remodeling. Here we explored the effects of danshensu, one water-soluble component of Danshen, on hypoxic pulmonary hypertension and its mechanism. Rats were exposed to hypobaric hypoxia for 4 weeks to develop hypoxic pulmonary hypertension along with administration of danshensu...
December 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29221312/port-access-thoracoscopic-bisubsegmentectomy-of-right-upper-lobe-posterior-and-anterior-segments
#2
Hirohisa Kato, Hiroyuki Oizumi, Jun Suzuki, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Mitsuaki Sadahiro
A 64-year-old woman was admitted to our hospital with a 16-mm non-solid tumor with pure ground-glass nodule (GGN) contents in the posterior segment near the anterior segment of her right upper lung lobe that was suspicious of adenocarcinoma in situ (AIS). Three-dimensional computed tomography (3DCT) simulation was performed to identify the subsegmental artery and vein pre- or intra-operatively. Port-access thoracoscopic bisubsegmentectomy of the right upper lobe was performed. A frozen section revealed AIS...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29209025/oblique-corpectomy-in-the-cervical-spine
#3
Tomasz Tykocki, Łukasz A Poniatowski, Marcin Czyz, Guy Wynne-Jones
STUDY DESIGN: A narrative review. OBJECTIVES: A literature review of studies reporting on the application of oblique corpectomy (OC) in various pathologies of the cervical spine. SETTING: UK. METHODS: A search was carried out using the PubMed and Google Scholar up to 18 March 2017. Finally, 26 studies met the inclusion criteria. RESULTS: A multilevel OC shows good clinical outcomes in various pathologies in the cervical spine...
December 5, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29207367/subadventitial-advancement-of-a-mother-and-child-catheter-to-allow-successful-recanalization-of-a-complex-in-stent-chronic-total-occlusion-testing-the-resistance-of-the-adventitia
#4
Luciano Candilio, Satoru Mitomo, Mauro Carlino, Antonio Colombo, Lorenzo Azzalini
In-stent chronic total occlusion (CTO) represents a challenging lesion subset for percutaneous coronary intervention (PCI), and although a true-to-true lumen crossing is the first-line strategy, a subadventitial approach may become necessary. Here we describe a case of successful in-stent right coronary artery CTO-PCI performed with subadventitial crossing, crushing of the occluded stents, and advancement of a mother-and-child catheter to the distal right coronary artery through the subadventitial space to allow stent delivery...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29205216/investigation-of-blood-flow-rheology-using-second-grade-viscoelastic-model-phan-thien-tanner-within-carotid-artery
#5
Abas Ramiar, Morsal Momenti Larimi, Ali Akbar Ranjbar
PURPOSE: Hemodynamic factors, such as Wall Shear Stress (WSS), play a substantial role in arterial diseases. In the larger arteries, such as the carotid artery, interaction between the vessel wall and blood flow affects the distribution of hemodynamic factors. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid and the effects of viscoelastic on blood flow in carotid artery is investigated. METHODS: Pulsatile flow studies were carried out in a 3D model of carotid artery...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29204771/comparison-of-blood-pressure-monitoring-by-applanation-tonometry-and-invasively-assessed-blood-pressure-in-cardiological-patients
#6
G Greiwe, S Hoffmann, L Herich, M S Winkler, C J Trepte, C R Behem, M Petzoldt, D A Reuter, S A Haas
The aim of this study was to evaluate the accuracy and precision of non-invasive continuous blood pressure measurement by applanation tonometry (AT) in awake or anaesthetised cardiological intensive care patients. Patients suffering from highly impaired left ventricular function atrial fibrillation or severe aortic valve stenosis were included into the study. Arterial blood pressure was recorded by applanation tonometry (T-Line 400, Tensys Medical®, USA) and an arterial line in awake or anaesthetised patients...
December 4, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29203579/heads-and-tails-of-natriuretic-peptides-neuroprotective-role-of-brain-natriuretic-peptide
#7
Héctor Fernández-Susavila, Manuel Rodríguez-Yáñez, Antonio Dopico-López, Susana Arias, María Santamaría, Paulo Ávila-Gómez, Juan M Doval-García, Tomás Sobrino, Ramón Iglesias-Rey, José Castillo, Francisco Campos
BACKGROUND: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first time the clinical association between BNP (by means of proBNP) and good outcome in ischemic stroke patients, and analyzed the effect of blood BNP increase in an ischemic animal model. METHODS AND RESULTS: A retrospective study with 2 different cohorts (262 patients in cohort I and 610 in cohort II) from the same prospective stroke registry was performed...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203066/-the-sural-medial-perforator-flap-anatomical-bases-surgical-technique-and-indications-in-head-and-neck-reconstruction
#8
S Struk, J-B Schaff, Q Qassemyar
INTRODUCTION: The medial sural artery perforator (MSAP) flap is defined as a thin cutaneo-adipose perforator flap harvested on the medial aspect of the leg. The aims of this study were to describe the anatomical basis as well as the surgical technique and discuss the indications in head and neck reconstructive surgery. MATERIAL AND METHODS: We harvested 10 MSAP flap on 5 fresh cadavers. For each case, the number and the location of the perforators were recorded...
December 1, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29198338/ponatinib-in-chronic-myeloid-leukemia-cml-consensus-on-patient-treatment-and-management-from-a-european-expert-panel
#9
REVIEW
Martin C Müller, Francisco Cervantes, Henrik Hjorth-Hansen, Jeroen J W M Janssen, Dragana Milojkovic, Delphine Rea, Gianantonio Rosti
Five tyrosine kinase inhibitors (TKIs) are currently approved in the European Union for treatment of chronic myeloid leukemia (CML) and all have considerable overlap in their indications. While disease-specific factors such as CML phase, mutational status, and line of treatment are key to TKI selection, other important features must be considered, such as patient-specific comorbidities and TKI safety profiles. Ponatinib, the TKI most recently approved, has demonstrated efficacy in patients with refractory CML, but is associated with an increased risk of arterial hypertension, sometimes severe, and serious arterial occlusive and venous thromboembolic events...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29189639/effects-of-closed-endotracheal-suctioning-on-systemic-and-cerebral-oxygenation-and-hemodynamics-in-children
#10
Madhuradhar Chegondi, Teshaun Francis, Wei-Chiang Lin, Sayed Naqvi, Andre Raszynski, Balagangadhar R Totapally
OBJECTIVES: To evaluate the effects of closed endotracheal tube suctioning on systemic oxygen saturation, cerebral regional oxygen saturation, and somatic regional (renal) oxygen saturation and hemodynamic variables in children. DESIGN: Prospective observational. SETTING: A tertiary care PICU. SUBJECTS: Children aged 0-18 years, requiring invasive mechanical ventilation and with an arterial line. INTERVENTIONS: Closed endotracheal suction...
November 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29188285/association-of-exercise-preconditioning-with-immediate-cardioprotection-a-review
#11
Dick H J Thijssen, Andrew Redington, Keith P George, Maria T E Hopman, Helen Jones
Importance: Exercise reduces the risk of cardiovascular events, including through an underrecognized, clinically useful form of acute cardioprotection accessible after a single episode of exercise, which is called cardiovascular preconditioning. Observations: Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits...
November 29, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29187381/crrl269-a-novel-designer-and-renal-enhancing-pgc-a-peptide-activator
#12
Yang Chen, Gail J Harty, Brenda K Huntley, Seethalakshmi R Iyer, Denise M Heublein, Gerald E Harders, Laura M G Meems, Shuchong Pan, S Jeson Sangaralingham, Tomoko Ichiki, John C Burnett
AIMS: The natriuretic peptides (NPs) b-type NP (BNP) and urodilatin (URO) exert renal protective properties via the particulate guanylyl cyclase A receptor (pGC-A). As a potential renal enhancing strategy, we engineered a novel designer peptide that we call CRRL269. CRRL269 was investigated in human cell lines and in normal canines to define potential cardiorenal enhancing actions. The mechanism of its cardiorenal selective properties was also investigated. METHODS AND RESULTS: In vitro NP receptor activity was quantified with 3', 5' cyclic guanosine monophosphate (cGMP) generation...
November 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29181682/effectiveness-of-hepatic-artery-infusion-hai-versus-selective-internal-radiation-therapy-y90-for-pretreated-isolated-unresectable-colorectal-liver-metastases-iu-crclm
#13
Mashaal Dhir, Mazen S Zenati, Heather L Jones, David L Bartlett, M Haroon A Choudry, James F Pingpank, Matthew P Holtzman, Nathan Bahary, Melissa E Hogg, Herbert J Zeh, David A Geller, J Wallis Marsh, Allan Tsung, Amer H Zureikat
BACKGROUND: In the era of modern effective systemic chemotherapy, the comparative effectiveness of hepatic artery infusion (HAI) versus selective internal radiation therapy (yttrium-90 [Y90]) for pretreated patients with isolated unresectable colorectal liver metastasis (IU-CRCLM) remains unknown. This study sought to compare the overall survival (OS) after HAI versus Y90 for IU-CRCLM patients treated with modern chemotherapy and to perform a cost analysis of both regional methods. METHODS: This study retrospectively reviewed patients receiving HAI or Y90 in combination with modern chemotherapy as second-line therapy for IU-CRCLM...
November 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29181655/the-organisation-of-the-acute-ischemic-stroke-management-key-notes-of-the-italian-neurological-society-and-of-the-italian-stroke-organization
#14
E Agostoni, A Carolei, G Micieli, L Provinciali, D Toni, Simone Vidale
The main aim of acute ischemic stroke treatment is the as much possible prompt, safe and effective arterial recanalisation, in order to restore reperfusion into the ischemic brain area. The procedures obtaining this result are rapidly evolving and in the last years, we observed new evidences that affirmed the therapeutical benefit of the concomitant treatment using endovenous thrombolysis and mechanical thrombectomy in selected patients with ischemic stroke. However, all treatments are time-sensitive and the main limitation for their application is represented by the time...
November 27, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29178987/time-to-threshold-as-a-new-indicator-of-circulatory-state-and-prognosis-in-patients-with-pulmonary-embolism
#15
Andreas Gunter Bach, Bettina-Maria Taute, Alexey Surov
BACKGROUND: Bolus tracking is commonly applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). TTT could be associated with the circulatory state, and ultimately with prognosis in patients with PE. AIM: The purpose of the present study was to examine the correlation of TTT with embolus burden, radiological and clinical parameters of circulatory state, and ultimately with 30-day mortality...
November 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29174503/external-validation-of-the-arterial-based-complexity-score-and-first-head-to-head-comparison-with-the-r-e-n-a-l-and-padua-scores-and-c-index
#16
Alessandro Antonelli, Alessandro Veccia, Marco Sandri, Maria Chiara Furlan, Stefano Recenti, Mario Sodano, Carlotta Palumbo, Alberto Cozzoli, Claudio Simeone
INTRODUCTION: We performed an external validation of the arterial-based complexity (ABC) score using a head-to-head comparison with the R.E.N.A.L. (radius, exophytic/endophytic tumor properties, nearness of tumor to deepest portion of collecting system or sinus, anterior/posterior descriptor, location relative to the polar line), PADUA (preoperative aspects and dimension for anatomic classification of renal tumors), and C-index scores for the prediction of surgical outcomes after partial nephrectomy...
November 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29173297/the-clinical-utility-and-safety-of-a-new-strategy-for-the-treatment-of-refractory-kawasaki-disease
#17
Takasuke Ebato, Shohei Ogata, Yoshihito Ogihara, Mayu Fujimoto, Atsushi Kitagawa, Manabu Takanashi, Masahiro Ishii
OBJECTIVE: To assess the clinical utility and safety of a strategy for refractory Kawasaki disease, defined by Egami score ≥3. STUDY DESIGN: First-line treatment was with intravenous methylprednisolone (30 mg/kg, 2 hours, 1 dose) plus intravenous immunoglobulin (2 g/kg, 24 hours) treatment. Patients resistant to first-line treatment received additional intravenous immunoglobulin as a second-line treatment. Patients resistant to second-line treatment who had received Bacillus Calmette-Guérin vaccination 6 months earlier were treated with infliximab; otherwise, plasma exchange was performed...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29172746/pazopanib-for-renal-cell-carcinoma-leads-to-elevated-mean-arterial-pressures-in-a-murine-model
#18
Amber Kempton, Cody Justice, Aaron Guo, Matthew Cefalu, Michael Makara, Paul Janssen, Thai H Ho, Sakima A Smith
BACKGROUND: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as hypertension, heart failure, and myocardial ischemia. OBJECTIVE: Define the in vivo role of pazopanib in the development of cardiotoxicity. METHODS: Wild type mice were dosed for 42 days via oral gavage, and separated into control and treatment (pazopanib) groups. Baseline ECG's, echocardiograms, and blood pressures were recorded...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29170412/ischemic-postconditioning-protects-against-intestinal-ischemia-reperfusion-injury-via-the-hif-1%C3%AE-mir-21-axis
#19
Zhongzhi Jia, Weishuai Lian, Haifeng Shi, Chuanwu Cao, Shilong Han, Kai Wang, Maoquan Li, Xiaoping Zhang
Intestinal ischemia/reperfusion (I/R) can lead to tissue damage associated with inflammation and mucosal apoptosis. Ischemic postconditioning (IPostC), a series of repeated, brief, intermittent periods of ischemia and reperfusion, has beneficial effects against I/R-induced injury in the heart and intestine, although the underlying mechanisms for these effects remain unclear. We evaluated the involvement of microRNA-21 (miR-21) in the protective effects of IPostC in a rat model of I/R induced by superior mesenteric artery occlusion and reopening...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29170348/51%C3%A2-paediatric-emergency-clinicians-are-rarely-exposed-to-non-airway-critical-procedures-a-predict-pern-study
#20
Juan P Garrahan, Mark Lyttle, Ed Oakley, Stuart Dalziel, Lucia Nguyen, Arjun Rao, Santiago Mintegi, Franz Babl
BACKGROUND: Recent studies suggest that approximately one per thousand paediatric ED attendances may require some sort of critical procedure, with intubation being by far the most common. It is unknown how often critical non-airway procedures such as chest decompression, CPR, ED thoracotomy, defibrillation, pacing, and advanced vascular access techniques are performed by paediatric emergency clinicians. OBJECTIVE: To determine the recent performance or supervision, and confidence for various paediatric critical non-airway procedures by senior paediatric emergency clinicians...
December 2017: Emergency Medicine Journal: EMJ
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