keyword
MENU ▼
Read by QxMD icon Read
search

Icariin

keyword
https://www.readbyqxmd.com/read/28812170/a-novel-approach-to-utilize-icariin-as-icariin-derived-ecm-on-small-intestinal-submucosa-scaffold-for-bone-repair
#1
Mei Li, Chi Zhang, Yi Zhong, Jiyuan Zhao
Icariin (Ic) has been demonstrated as a potent osteoinductive compound for bone tissue engineering. However, toxic side effects of the drug and poor biocompatibility of drug delivery systems (DDSs) still limit its application for bone repair in the clinic. To overcome these disadvantages and utilize the osteoinductivity of Ic, we developed a novel method to utilize Ic as an Ic-derived osteoinductive extracellular matrix (ECM) on small intestinal submucosa (SIS) (Ic-ECM-SIS). The generated Ic-ECM-SIS scaffolds, as a natural construct, exhibited much better biocompatibility (including cell adhesion, cell survival and cell proliferation) than Ic-SIS scaffolds generated by traditional DDSs...
August 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28810527/icariin-combined-with-snailase-shows-improved-intestinal-hydrolysis-and-absorption-in-osteoporosis-rats
#2
Congyan Liu, Xia Gao, Yuping Liu, Mengmeng Huang, Ding Qu, Yan Chen
Icariin has a significant anti-osteoporotic activity, but its clinical application is limited due to a poor oral bioavailability especially under pathological conditions like osteoporosis. Based on the intestinal absorption and metabolism characteristics of icariin in the osteoporosis rats, a kind of simple enteric capsules containing icariin and snailase was designed to overcome this issue in this study. Snailase was secleted as the most efficient exogenous hydrolase of icariin and the related hydrolysis reaction parameters were optimized in the artificial intestinal liquid...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28742995/icaritin-induces-mc3t3-e1-subclone14-cell-differentiation-through-estrogen-receptor-mediated-erk1-2-and-p38-signaling-activation
#3
Zhidi Wu, Ling Ou, Chaopeng Wang, Li Yang, Panpan Wang, Hengrui Liu, Yingquan Xiong, Kehuan Sun, Ronghua Zhang, Xiaofeng Zhu
Icaritin (ICT), a hydrolytic product of icariin from the genus Epimedium, has many indicated pharmacological and biological activities. Several studies have shown that ICT has potential osteoprotective effects, including stimulation of osteoblast differentiation and inhibition of osteoclast differentiation. However, the molecular mechanism for this anabolic action of ICT remains largely unknown. Here, we found that ICT could enhance MC3T3-E1 subclone 14 preosteoblastic cell differentiation associated with increased mRNA levels and protein expression of the differentiation markers alkaline phosphatase (ALP), type 1 collagen (COL1), osteocalcin (OC), osteoponin (OPN) and runt-related transcription factor 2 (RUNX2), and improved mineralization, confirmed by bone nodule formation and collagen synthesis...
July 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28698566/evaluation-of-osteogenesis-and-angiogenesis-of-icariin-in-local-controlled-release-and-systemic-delivery-for-calvarial-defect-in-ovariectomized-rats
#4
Yuqiong Wu, LingYan Cao, Lunguo Xia, Qianju Wu, Jie Wang, Xiao Wang, Lianyi Xu, Yuning Zhou, Yuanjin Xu, Xinquan Jiang
Typically, bone regenerative medicine is applied to repair bone defects in patients with osteoporosis. Meanwhile, there is an urgent need to develop safe and cheap drugs that induce bone formation. Icariin, which is reported to promote the osteogenesis of stem cells in vitro, is the main active component of Herba Epimedii. However, whether icariin could repair bone defects caused by osteoporosis remains unknown. In this study, an osteoporosis model in rats was established by an ovariectomy first, and then, the osteogenic and angiogenic differentiation of bone mesenchymal stem cells (BMSCs) treated with icariin was evaluated...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28681147/therapeutic-effect-of-icariin-combined-with-stem-cells-on-postmenopausal-osteoporosis-in-rats
#5
Dao Tang, Cuiling Ju, Yanjie Liu, Fei Xu, Zhengguang Wang, Dongbo Wang
Osteoporosis is characterized by skeletal fragility and microarchitectural deterioration. The side effects of drugs to treat osteoporosis will negatively affect the health of patients. This study aimed to investigate the therapeutic effects of icariin combined with adipose-derived stem cells on osteoporosis in a postmenopausal osteoporosis model after ovariectomy in rats. After ovariectomy the rats were treated with icariin combined with adipose-derived stem cell transplantation. The levels of alkaline phosphatase, tartrate-resistant acid phosphatase, osteoprotegerin, and bone γ-carboxyglutamate protein in serum were determined by ELISA...
July 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28680528/protective-effect-of-icariin-on-the-development-of-preimplantation-mouse-embryos-against-hydrogen-peroxide-induced-oxidative-injury
#6
Rong Ye, Songhua Xu, Yue Liu, Lili Pang, Xiuli Lian, Yuhuan Zhong, Yang Su, Shie Wang
During in vitro cultivation of preimplantation embryos, the balance between ROS production and clearance is disturbed and may lead to incompetent embryos, which might be a main reason of IVF-ET failure. Icariin (ICA) is reported to be active in clearing ROS. The present study aimed to investigate whether ICA could reverse H2O2 pretreatment-induced mouse preimplantation embryo development arrest and, furthermore, to study the underlying mechanisms by detecting ROS levels, mitochondrial membrane potential (ΔΨm), and zygotic gene expression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28669561/effects-of-icariin-on-asthma-mouse-model-are-associated-with-regulation-of-prostaglandin-d2-level
#7
J Qiao, S Sun, L Yuan, J Wang
BACKGROUND: We aimed to observe the effect of icariin on an asthma mouse model and explore the potential underlying mechanisms. METHODS: The asthma mouse model was established by ovalbumin (OVA) sensitisation and respiratory syncytial virus (RSV) infection and then treated with icariin. Airway resistance was assessed by whole body plethysmograph. In addition, pathological slides were stained with haematoxylin-eosin, and the peribronchial inflammation was observed microscopically...
June 29, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28667862/icariin-exerts-inhibitory-effects-on-the-growth-and-metastasis-of-kyse70-human-esophageal-carcinoma-cells-via-pi3k-akt-and-stat3-pathways
#8
Zhen-Fang Gu, Zi-Teng Zhang, Jun-Ye Wang, Bao-Bin Xu
Esophageal cancer is one of the leading causes of cancer related mortality across the globe. The current treatment options are insufficient and are associated with number of side effects. Therefore there is a pressing need to develop effective and more efficient strategies for the treatment of esophageal cancer. Consistently, natural products are considered potential candidates for develop of cancer chemotherapy. Icariin is a naturally occurring flavonol glucoside and has been reported to possess tremendous pharmacological potential ranging from neuroprotection to anticancer activity...
June 19, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28662275/childhood-cancer-chemotherapy-induced-bone-damage-pathobiology-and-protective-effects-of-resveratrol-and-other-nutraceuticals
#9
REVIEW
Yu-Wen Su, Ke-Ming Chen, Mohammadhossein Hassanshahi, Qian Tang, Peter R Howe, Cory J Xian
Intensive cancer chemotherapy causes significant bone loss, for which the mechanisms remain unclear and effective treatments are lacking. This is a significant issue particularly for childhood cancers, as the most common ones have a >75% cure rate following chemotherapy; there is an increasing population of survivors who live with chronic bone defects. Studies suggest that these defects are the result of reduced bone from increased marrow fat formation and increased bone resorption following chemotherapy...
June 29, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28635220/-the-bisphenol-a-enhanced-activity-of-thyroid-carcinoma-cell-line-b-cpap-is-inhibited-by-icarrin
#10
C M Zheng, X Z Liu, Q L Li, J F Wang, Z Tan, M H Ge
Objective: To investigate the effect of icariin (ICA) on the bisphenol A (BPA)-enhanced proliferation function of thyroid carcinoma cell B-CPAP and underlying mechanism. Methods: The proliferation of Gastric B-CPAP cell line was evaluated by cell counting kit-8 (CCK-8). Apoptosis and ROS expression in B-CPAP cells were detected by flow cytometry. The expression of superoxide dismutase (SOD) and malondialdehyde (MDA) in B-CPAP cells were measured by individual assay kits. The expressions of Bcl-2 and γ-HA2X were detected by Western blot...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28629034/icariin-immobilized-electrospinning-poly-l-lactide-fibrous-membranes-via-polydopamine-adhesive-coating-with-enhanced-cytocompatibility-and-osteogenic-activity
#11
Hua Liu, Wenling Li, Binghong Luo, Xuexing Chen, Wei Wen, Changren Zhou
In this study, icariin (ICA), one of the main active ingredients of Herba Epimedii for osteogenesis, was applied to functionalize electrospinning poly(l-lactide) (PLLA) fibrous membrane via an intermediate layer of polydopamine (PDA) to obtain enhanced cytocompatibility and osteogenic activity. For this purpose, an array of PDA-coated PLLA fibrous membranes (PLLA-0.5PDA, PLLA-1PDA, PLLA-2PDA, PLLA-5PDA) and ICA-modified PLLA-2PDA fibrous membranes (PLLA-2PDA-10ICA, PLLA-2PDA-20ICA, PLLA-2PDA-40ICA) were successively prepared...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28619001/icariin-attenuates-interleukin-1%C3%AE-induced-inflammatory-response-in-human-nucleus-pulposus-cells
#12
Wen-Bin Hua, Yu-Kun Zhang, Xing-Huo Wu, Liang Kang, Ji Tu, Kang-Cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-Jin Luo, Zeng-Wu Shao, Cao Yang
BACKGROUND: Low back pain is a common problem, mainly caused by intervertebral disc degeneration (IDD). An important pathophysiological characteristic of IDD is the loss of homeostatic balance of the extracellular matrix metabolism. Interleukin-1β (IL-1β) is one of the inflammatory mediators stimulating the degradation of extracellular matrix in the nucleus pulposus (NP) and contributing to IDD pathogenesis. Icariin, which is isolated from Epimedium brevicornum, acts as an anti-inflammatory drug...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28611679/icariin-a-novel-blocker-of-sodium-and-calcium-channels-eliminates-early-and-delayed-afterdepolarizations-as-well-as-triggered-activity-in-rabbit-cardiomyocytes
#13
Wanzhen Jiang, Mengliu Zeng, Zhenzhen Cao, Zhipei Liu, Jie Hao, Peipei Zhang, Youjia Tian, Peihua Zhang, Jihua Ma
Icariin, a flavonoid monomer from Herba Epimedii, has confirmed pharmacological and biological effects. However, its effects on arrhythmias and cardiac electrophysiology remain unclear. Here we investigate the effects of icariin on ion currents and action potentials (APs) in the rabbit myocardium. Furthermore, the effects of icariin on aconitine-induced arrhythmias were assessed in whole rabbits. Ion currents and APs were recorded in voltage-clamp and current-clamp mode in rabbit left ventricular myocytes (LVMs) and left atrial myocytes (LAMs), respectively...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28608834/multi-dimensional-spectrum-effect-relationship-of-the-impact-of-chinese-herbal-formula-lichong-shengsui-yin-on-ovarian-cancer
#14
Yanhong Wang, Yang Li, Yan Zhang, Guan Feng, Zhixin Yang, Qingxia Guan, Rui Wang, Fengjuan Han
Lichong Shengsui Yin (LCSSY) is an effective and classic compound prescription of Traditional Chinese Medicines (TCMs) used for the treatment of ovarian cancer. To investigate its pharmacodynamic basis for treating ovarian cancer, the multi-dimensional spectrum-effect relationship was determined. Four compositions (I to IV) were obtained by extracting LCSSY successively with supercritical CO₂ fluid extraction, 75% ethanol reflux extraction, and the water extraction-ethanol precipitation method. Nine samples for pharmacological evaluation and fingerprint analysis were prepared by changing the content of the four compositions...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28608833/potential-of-icariin-metabolites-from-epimedium-koreanum-nakai-as-antidiabetic-therapeutic-agents
#15
Da Hye Kim, Hyun Ah Jung, Hee Sook Sohn, Jin Woong Kim, Jae Sue Choi
The therapeutic properties of Epimediumkoreanum are presumed to be due to the flavonoid component icariin, which has been reported to have broad pharmacological potential and has demonstrated anti-diabetic, anti-Alzheimer's disease, anti-tumor, and hepatoprotective activities. Considering these therapeutic properties of icariin, its deglycosylated icaritin and glycosylated flavonoids (icaeriside II, epimedin A, epimedin B, and epimedin C) were evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28574448/simultaneous-quantification-of-multiple-representative-components-in-the-xian-ling-gu-bao-capsule-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#16
Zhi-Hong Yao, Zi-Fei Qin, Hong Cheng, Xiao-Meng Wu, Yi Dai, Xin-Luan Wang, Ling Qin, Wen-Cai Ye, Xin-Sheng Yao
Xian-Ling-Gu-Bao capsule (XLGB), a famous traditional Chinese medicine prescription, is extensively used for the treatment of osteoporosis in China. However, few studies on the holistic quality control of XLGB have been reported. In this study, a reliable method using 18 representative components in XLGB was successfully established and applied to evaluate 34 batches of XLGB samples by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The choice of quantitative markers mostly followed four principles, i...
June 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28565854/effect-of-icariin-on-fracture-healing-in-an-ovariectomized-rat-model-of-osteoporosis
#17
Hong Cao, Ying Zhang, Wei Qian, Xiao-Peng Guo, Chen Sun, Lei Zhang, Xin-Hua Cheng
Osteoporosis is frequently asymptomatic, presenting a significant clinical and economic burden, particularly following an osteoporosis-associated fracture. Icariin has been reported to inhibit osteoporosis in vitro, and the present study investigated whether icariin also promoted bone fracture healing in ovariectomized osteoporotic (OVX) rats in vivo. A total of 30 female rats were randomly divided into three groups (n=10 per group): i) Sham surgery; ii) OVX; and iii) OVX with icariin (OVX + ICA) groups. At 3 months after the ovariectomy, a unilateral cross-tibia fracture was made at the proximal right tibia...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28536643/icariin-prevents-h2o2-induced-apoptosis-via-the-pi3k-akt-pathway-in-rat-nucleus-pulposus-intervertebral-disc-cells
#18
Xiangyu Deng, Sheng Chen, Dong Zheng, Zengwu Shao, Hang Liang, Hongzhi Hu
Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum. This study investigated the mechanism by which icariin prevents H2O2-induced apoptosis in rat nucleus pulposus (NP) cells. NP cells were isolated from the rat intervertebral disc and they were divided into five groups after 3 passages: (A) blank control; (B) 200 μM H2O2; (C) 200 μM H2O2 + 20 μM icariin; (D) 20 μM icariin + 200 μM H2O2 + 25 μM LY294002; (E) 200 μM H2O2 + 25 μM LY294002. LY294002 is a selective inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28525525/morphological-observation-on-critical-sized-cranial-defect-repaired-by-icariin-and-autologous-concentrate-growth-factors-in-rabbits
#19
Gang Li, Jie Wang, Guiyun Ren, Fuliang Hao, Yanning Zhang, Peikai Shi, Xiao Liu, Fusheng Dong
BACKGROUND Morphological changes repaired by icariin and autologous concentrate growth factors (ACGF) in critical-sized cranial defect were observed and their promoting effects were investigated. MATERIAL AND METHODS Seventy-two New Zealand white rabbits weighing 1.8~2.0kg were used to build a critical-sized cranial defect model and were randomly divided into 3 groups. X-ray, HE staining, general and histological observation, and immunohistochemistry were used to describe the changes caused by normal saline, icariin, and ACGF...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28505603/icariin-protects-against-thioacetamide-induced-liver-fibrosis-in-rats-implication-of-anti-angiogenic-and-anti-autophagic-properties
#20
Mardi M Algandaby, Randa M Breikaa, Basma G Eid, Thikrayat A Neamatallah, Ashraf B Abdel-Naim, Osama M Ashour
BACKGROUND: Liver fibrosis is a major health problem. The current study evaluated the potential of icariin (ICA) to guard against thioacetamide (TAA)-induced liver fibrosis in rats. METHODS: Four groups of male rats were treated as follows: group 1 was the control group, group 2 was given TAA (200mg/kg), group 3 was administered ICA (50mg/kg) and TAA (200mg/kg), and group 4 was given ICA (50mg/kg) alone. Animal treatment was continued for four weeks. RESULTS: Co-administration of ICA guarded against TAA hepatotoxicity as indicated by significant inhibition in the rise of serum ALT and AST activities and albumin concentrations...
February 24, 2017: Pharmacological Reports: PR
keyword
keyword
71241
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"