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Jong-Hyeon Park, Dongseob Tark, Kwang-Nyeong Lee, Ji-Eun Chun, Hyang-Sim Lee, Young-Joon Ko, Soo-Jeong Kye, Yong-Joo Kim, Jae-Ku Oem, Soyoon Ryoo, Sung-Bin Lim, Seo-Yong Lee, Joo-Hyung Choi, Mi-Kyeong Ko, Su-Hwa You, Myoung-Heon Lee, Byounghan Kim
On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak occurred in South Korea. Although vaccinations were administered, cases of FMD increased steadily for five months and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccinations. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea from April 2010 to July 2014. However, the virus in December 2014 had a unique difference in a partial deletion of the 5' noncoding region, which had not been seen in the previous SEA topotype isolates that were identified in Korea...
November 23, 2017: Journal of Veterinary Science
Ting Fu, Luis Miranda-Moreno, Nicolas Saunier
This paper proposes a new framework to evaluate pedestrian safety at non-signalized crosswalk locations. In the proposed framework, the yielding maneuver of a driver in response to a pedestrian is split into the reaction and braking time. Hence, the relationship of the distance required for a yielding maneuver and the approaching vehicle speed depends on the reaction time of the driver and deceleration rate that the vehicle can achieve. The proposed framework is represented in the distance-velocity (DV) diagram and referred as the DV model...
November 20, 2017: Accident; Analysis and Prevention
Arianne Lewyllie, Maria Cadenas De Llano-Pérula, Anna Verdonck, Guy Willems
OBJECTIVES: To systematically review the xmethodological quality of three-dimensional (3D) imaging studies of patients with craniofacial syndromes and to propose recommendations for future research. METHODS: PubMed, Embase and Cochrane databases as well as Grey literature were electronically searched. Inclusion criteria were patients with genetic syndromes with craniofacial manifestations and 3D imaging of facial soft and/or hard tissues. Exclusion criteria consisted of non-syndromic conditions or conditions due to environmental causes, injury or trauma, facial soft and hard tissues not included in the image analysis, case reports, reviews, opinion articles...
November 23, 2017: Dento Maxillo Facial Radiology
D Tsakogiannis, G D Moschonas, E Bella, Z Kyriakopoulou, G D Amoutzias, T G Dimitriou, C Kottaridi, P Markoulatos
The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3'UTR of exon 3 of p16 gene are implicated in several types of cancer, while their role in cervical cancer development remains rather vague. In the present study, we investigated for the impact of p16 genotypes/haplotypes on patients' vulnerability to cervical disease and examined whether these factors can be used as progression markers in the Greek population...
November 23, 2017: Journal of Medical Virology
Inmaculada Salcedo-Bellido, Juan Miguel Martínez-Galiano, Rocío Olmedo-Requena, Juan Mozas-Moreno, Aurora Bueno-Cavanillas, Jose J Jimenez-Moleon, Miguel Delgado-Rodríguez
Pregnancy increases the requirements of certain nutrients, such as vitamins, to provide nutrition for the newborn. The aim was to analyze the association between dietary intake of vitamins during pregnancy and risk of having a small for gestational age (SGA) newborn. A matched case-control study was conducted (518 cases and 518 controls of pregnant women) in Spain. Dietary vitamin intake during pregnancy was assessed using a validated food frequency questionnaire, categorized into quintiles. Odds ratios (ORs) and their 95% confidence intervals (CI) were estimated with conditional regression logistic models...
November 23, 2017: Nutrients
Luz Maria De-Regil, Maria Elena D Jefferds, Juan Pablo Peña-Rosas
BACKGROUND: Approximately 600 million children of preschool and school age are anaemic worldwide. It is estimated that at least half of the cases are due to iron deficiency. Point-of-use fortification of foods with micronutrient powders (MNP) has been proposed as a feasible intervention to prevent and treat anaemia. It refers to the addition of iron alone or in combination with other vitamins and minerals in powder form, to energy-containing foods (excluding beverages) at home or in any other place where meals are to be consumed...
November 23, 2017: Cochrane Database of Systematic Reviews
Nicolas Kern, Mateusz P Plesniak, Joseph J W McDouall, David J Procter
The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step. Unfortunately, carrying out reactions with radicals in an enantiocontrolled fashion remains challenging due to their high reactivity. This is particularly the case for reactions of radicals generated using the classical reagent, SmI2...
December 2017: Nature Chemistry
Vladimir V Korolkov, Matteo Baldoni, Kenji Watanabe, Takashi Taniguchi, Elena Besley, Peter H Beton
Two-dimensional (2D) supramolecular arrays provide a route to the spatial control of the chemical functionality of a surface, but their deposition is in almost all cases limited to a monolayer termination. Here we investigated the sequential deposition of one 2D array on another to form a supramolecular heterostructure and realize the growth-normal to the underlying substrate-of distinct ordered layers, each of which is stabilized by in-plane hydrogen bonding. For heterostructures formed by depositing terephthalic acid or trimesic acid on cyanuric acid/melamine, we have determined, using atomic force microscopy under ambient conditions, a clear epitaxial arrangement despite the intrinsically distinct symmetries and/or lattice constants of each layer...
December 2017: Nature Chemistry
Jyothi Bhat, V G Rao, R K Sharma, M Muniyandi, Rajiv Yadav, M K Bhondley
BACKGROUND & OBJECTIVES: Prevalence of pulmonary tuberculosis (PTB) is known to be high in the indigenous tribal community Saharia in Madhya Pradesh, India. The risk factors for PTB are not well known among them. This study was done to determine various risk factors associated with PTB in the indigenous community Saharia. METHODS: A prevalence survey was conducted among Saharias of Gwalior district of Madhya Pradesh. The population surveyed was 12,123 which was the source of cases and controls for the present study...
July 2017: Indian Journal of Medical Research
Kemal Utku Yazici, Ipek Percinel Yazici, Bilal Ustundag
BACKGROUND: Recent studies showed that vitamin D deficiency may lead to dysfunctional changes in the brain and may be associated with neuropsychiatric diseases. AIMS: The present study aims to investigate vitamin D, calcium, phosphorus and alkaline phosphatase levels in children and adolescents diagnosed with obsessive-compulsive disorder (OCD) and compared them to healthy controls. Additionally, the correlation of OCD symptom severity with serum vitamin D level will be analyzed...
November 23, 2017: Nordic Journal of Psychiatry
Önder Doksöz, Hikmet Tekin Nacaroğlu, Gökhan Ceylan, Mehmet Çeleğen, Şenay Aşık-Nacaroğlu, Demet Can, Timur Meşe, Nurettin Ünal
Doksöz Ö, Nacaroğlu HT, Ceylan G, Çeleğen M, Aşık-Nacaroğlu Ş, Can D, Meşe T, Ünal N. The evaluation of right and left ventricular functions in children with episodic wheezing exposed to environmental tobacco smoke. Turk J Pediatr 2017; 59: 42-48. The objective of this study is to examine the right and left ventricular functions in children with episodic wheezing at the ages of 1-3 exposed to environmental tobacco smoke (ETS). Thirty-two children monitored at the Pediatric Allergy and Immunology Department of a Research and Training Hospital with the diagnosis of episodic wheezing were included...
2017: Turkish Journal of Pediatrics
İpek Güney-Varal, Nilgün Köksal, Hilal Özkan, Onur Bağcı, Pelin Doğan
Güney-Varal İ, Köksal N, Özkan H, Bağcı O, Doğan P. The effect of early administration of combined multi-strain and multi-species probiotics on gastrointestinal morbidities and mortality in preterm infants: A randomized controlled trial in a tertiary care unit. Turk J Pediatr 2017; 59: 13-19. Necrotizing enterocolitis (NEC) is a gastrointestinal emergency of the neonatal period. The aim of this study was to demonstrate the use of multistrain and multispecies probiotic on gastrointestinal morbidities and mortality...
2017: Turkish Journal of Pediatrics
Raquel E Reinbolt, Stephen Sonis, Cynthia D Timmers, Juan Luis Fernández-Martínez, Ana Cernea, Enrique J de Andrés-Galiana, Sepehr Hashemi, Karin Miller, Robert Pilarski, Maryam B Lustberg
Many breast cancer (BC) patients treated with aromatase inhibitors (AIs) develop aromatase inhibitor-related arthralgia (AIA). Candidate gene studies to identify AIA risk are limited in scope. We evaluated the potential of a novel analytic algorithm (NAA) to predict AIA using germline single nucleotide polymorphisms (SNP) data obtained before treatment initiation. Systematic chart review of 700 AI-treated patients with stage I-III BC identified asymptomatic patients (n = 39) and those with clinically significant AIA resulting in AI termination or therapy switch (n = 123)...
November 23, 2017: Cancer Medicine
Christel C L M Boons, Lonneke Timmers, Natasja M van Schoor, Eleonora L Swart, N Harry Hendrikse, Jeroen J W M Janssen, Jacqueline G Hugtenburg
Adequate information on oral anticancer agent (OACA) use is an essential element of optimal cancer care. The present study aimed to get insight into the experiences of patients with information on OACA treatment and their characteristics regarding information dissatisfaction. Patients of four Dutch university hospitals using OACA participated in this observational study and completed the Satisfaction with Information about Medicines Scale (SIMS), EORTC Quality of Life Questionnaire-C30, Brief Illness Perception Questionnaire, and Beliefs about Medicines Questionnaire-Specific...
November 23, 2017: Cancer Medicine
S Das, C Baruah, A K Saikia, S Bose
Rheumatoid arthritis (RA) is a complex, multifactorial, systemic autoimmune disease. Reports are suggestive of the role of HLA especially HLA-DRB1 alterations in RA pathogenesis. Existing data involving different geographical populations on the role of alterations in specific locus of HLA-DRB1 in RA susceptibility and severity are equivocal, with no data available from ethnically distinct North-east Indian population, where RA cases are alarmingly increasing. This study aimed to evaluate the association of HLA-DRB1 gene SNPs (rs13192471, rs660895 and rs6457617) with susceptibility and severity of RA in an ethnically distinct North-east Indian population...
November 23, 2017: International Journal of Immunogenetics
Julia So Severo, Aline Elisa Santana, Valeria Aoki, Nilceo S Michalany, Matheus Matioli Mantovani, Carlos Eduardo Larsson, Carlos Eduardo Larsson
BACKGROUND: C-reactive protein (CRP) is a major acute phase protein in dogs and may be an inflammatory marker of autoimmune diseases. HYPOTHESIS/OBJECTIVES: To measure pre- and post-treatment CRP levels in dogs with superficial pyoderma (SP) and pemphigus foliaceus (PF) compared to normal dogs; to evaluate possible correlation between CRP values, indirect immunofluorescence (IIF), and pemphigus foliaceus extent and severity index (PEFESI) scores. ANIMALS: Fifty nine dogs divided into three groups: Group I (control, n = 31), Group II (SP, n = 14) and Group III (PF, n = 14)...
November 22, 2017: Veterinary Dermatology
Laure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renee T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, Rosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A Schmidt, Kay-Tee Khaw, Konstantinos K Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
Bensong Duan, Jiangfeng Hu, Hongliang Liu, Yanru Wang, Hongyu Li, Shun Liu, Jichun Xie, Kouros Owzar, James Abbruzzese, Herbert Hurwitz, Hengjun Gao, Qingyi Wei
The PDGF signaling pathway plays important roles in development and progression of human cancers. In this study, we aimed to identify genetic variants of the PDGF pathway genes associated with pancreatic cancer risk in European populations by using three published GWAS datasets, which consisted of 9,381 cases and 7,719 controls. The expression quantitative trait loci (eQTL) analysis was also performed by using data from the 1000 Genomes, TCGA and GTEx projects. As a result, we identified two potential susceptibility loci (rs5757573 and rs6001516) of PDGFB associated with pancreatic cancer risk [odds ratio (OR) = 1...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
Faris Tarlochan, Hassan Mehboob, Ali Mehboob, Seung-Hwan Chang
Cementless hip prostheses with porous outer coating are commonly used to repair the proximally damaged femurs. It has been demonstrated that stability of prosthesis is also highly dependent on the bone ingrowth into the porous texture. Bone ingrowth is influenced by the mechanical environment produced in the callus. In this study, bone ingrowth into the porous structure was predicted by using a mechano-regulatory model. Homogenously distributed pores (200 and 800 [Formula: see text]m in diameter) and functionally graded pores along the length of the prosthesis were introduced as a porous coating...
November 22, 2017: Biomechanics and Modeling in Mechanobiology
Jinbing Bai, Madhusmita Behera, Deborah Watkins Bruner
PURPOSE: The gut microbiome plays a critical role in maintaining children's health and in preventing and treating children's disease. Current application of the gut microbiome in childhood cancer is still lacking. This study aimed to systematically review the following: (1) alternations in the gut microbiome throughout cancer treatment trajectories in children, (2) the associations between the gut microbiome and gastrointestinal (GI) symptoms and psychoneurological symptoms (PNS), and (3) the efficacy of therapeutic interventions in the gut microbiome in children with cancer...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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