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Posterior fossa tumors

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https://www.readbyqxmd.com/read/29774098/establishment-of-primary-cell-culture-and-an-intracranial-xenograft-model-of-pediatric-ependymoma-a-prospect-for-therapy-development-and-understanding-of-tumor-biology
#1
Lorena Favaro Pavon, Tatiana Tais Sibov, Silvia Regina Caminada de Toledo, Daniela Mara de Oliveira, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Luciana C Marti, Jackeline Moraes Malheiros, Edgar Ferreira da Cruz, Fernando F Paiva, Suzana M F Malheiros, Manoel A de Paiva Neto, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Nasjla Saba Silva, Andrea Maria Cappellano, Antonio Sérgio Petrilli, Ana Marisa Chudzinski-Tavassi, Sérgio Cavalheiro
Background: Ependymoma (EPN), the third most common pediatric brain tumor, is a central nervous system (CNS) malignancy originating from the walls of the ventricular system. Surgical resection followed by radiation therapy has been the primary treatment for most pediatric intracranial EPNs. Despite numerous studies into the prognostic value of histological classification, the extent of surgical resection and adjuvant radiotherapy, there have been relatively few studies into the molecular and cellular biology of EPNs...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29770250/the-usefulness-of-indocyanine-green-during-surgery-for-hypervascular-posterior-fossa-tumors
#2
Takahiro Shinya, Hideki Nagamine, Ken-Ichi Sugawara, Shogo Ishiuchi
Background: Cerebral hemangioblastomas are benign tumors with abundant blood flow that occur mainly in the posterior fossa. Tumor removal en bloc is important in surgical treatment because of the risk of bleeding; however, it is actually rather difficult in practice. Therefore, we propose a surgical strategy for visualizing hypervascular tumors of the posterior fossa utilizing indocyanine green (ICG). Case Description: Case 1 involved a 48-year-old male with a history of von Hippel-Lindau (VHL) disease...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29770223/profound-hearing-loss-following-surgery-in-pediatric-patients-with-posterior-fossa-low-grade-glioma
#3
Yahya Ghazwani, Ibrahim Qaddoumi, Johnnie K Bass, Shengjie Wu, Jason Chiang, Frederick Boop, Amar Gajjar, Zsila Sadighi
Background: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. Methods: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology...
May 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29765890/intraoperative-monitoring-of-hypoglossal-nerve-using-hypoglossal-motor-evoked-potential-in-infratentorial-tumor-surgery-a-report-of-two-cases
#4
Seung Yeun Kim, Hyo Won Im, Young-Doo Choi, Keewon Kim, Jin Wook Kim, Yong Hwy Kim, Han Gil Seo
The hypoglossal nerve (CN XII) may be placed at risk during posterior fossa surgeries. The use of intraoperative monitoring (IOM), including the utilization of spontaneous and triggered electromyography (EMG), from tongue muscles innervated by CN XII has been used to reduce these risks. However, there were few reports regarding the intraoperative transcranial motor evoked potential (MEP) of hypoglossal nerve from the tongue muscles. For this reason, we report here two cases of intraoperative hypoglossal MEP monitoring in brain surgery as an indicator of hypoglossal deficits...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29764030/-neuroendoscopy-assisted-microneurosurgery-for-posterior-cranial-fossa-lesion
#5
J Li, D Zhong, D Lü, H Y Huang, W Du, J Yang, Y T Wu, H J Xia, W Y Tang, X C Sun
Objective: To study the value of neuroendoscopy assisted microneurosurgery technique in the treatment of posterior cranial fossa lesion. Methods: Clinical data of 36 patients with posterior fossa lesions who accepted neuroendoscopy assisted microneurosurgery (NEAM group) in the department of neurosurgery of the First Affiliated Hospital of Chongqing Medical University, from January 2014 to December 2016, were retrospectively enrolled. A total of 113 cases diagnosed with the same lesions and accepted conventional microneurosurgery (non-NEAM group) in the same period were analyzed as control group...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29758594/phox2b-is-a-reliable-immunomarker-in-distinguishing-peripheral-neuroblastic-tumors-from-cns-embryonal-tumors
#6
Sanda Alexandrescu, Vera Paulson, Adrian Dubuc, Azra Ligon, Hart G Lidov
INTRODUCTION: The PHOX2B gene regulates neuronal maturation in the brain stem nuclei associated with cardiorespiratory function, and in the autonomic sympathetic and enteric nervous system. PHOX2B expression is a reliable immunomarker for peripheral neuroblastic tumors, however no systematic evaluation of CNS embryonal tumors was included in the studies. We encountered two cases in which the differential diagnosis included neuroblastoma and CNS embryonal tumor, and we hypothesized that PHOX2B immunostain would be helpful establishing the diagnosis...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29753895/infected-intradural-dermoid-cyst-with-complete-dermal-sinus-of-posterior-fossa
#7
Félix K K Ségbédji, A J Tokpo, A A Nubukpo-Guménu, N K Alaoui, L M A Quenum, K Chakour, M F Chaoui, M Benzagmout
BACKGROUND: Intracranial dermoid cysts represent benign embryologic tumors. Children and young adults are most affected. Infected intradural dermoid cyst with complete dermal sinus of posterior fossa is exceptional. The main feature of this dermal sinus leads from the midline intradural cyst through an opening in the occipital bone to be attached to the skin. METHOD: We report two cases of infected intradural dermoid cyst with complete dermal sinus of posterior fossa in children, with special attention to the clinical, anatomical features of this rare combination...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29745267/pilocytic-astrocytoma-with-spontaneous-malignant-transformation-with-intracranial-and-skeletal-dissemination-case-report-and-review-of-the-literature
#8
Subhas K Konar, B N Nandeesh, M Sandhya, N Chandana, B Indira Devi, Dhananjaya I Bhat
Pilocytic astrocytoma is a benign low-grade tumor with a favorable prognosis. We present a 47-year-old- lady with a posterior fossa pilocytic astrocytoma who underwent surgical decompression. She developed multiple early local recurrences Along with malignant transformation of the cranial lesion she developed skeletal dissemination within a very short time frame. There were no features or family history of neurofibromatosis 1. She did not receive radiotherapy or chemotherapy prior to the recurrences.
May 10, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29742711/pituitary-apoplexy-following-lumbar-fusion-surgery-in-prone-position-a-case-report
#9
Chunghee Joo, Geol Ha, Yeon Jang
RATIONALE: Pituitary apoplexy (PA) is a syndrome caused by acute hemorrhage or infarction of the pituitary gland, generally within a pituitary adenoma. PA following spinal surgery is a very rare complication and may be difficult to diagnose. However, early diagnosis of PA is essential for the timely treatment of pan-hypopituitarism and prevention of severe neurologic complications. PATIENT CONCERNS: A 73-year-old man had a posterior lumbar fusion surgery over a period of 8 hours on prone position...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741274/neurologic-impairments-from-pediatric-low-grade-glioma-by-tumor-location-and-timing-of-diagnosis
#10
Zsila S Sadighi, Elizabeth Curtis, Jennifer Zabrowksi, Catherine Billups, Amar Gajjar, Raja Khan, Ibrahim Qaddoumi
BACKGROUND: The neurologic outcomes of low-grade gliomas (LGGs) according to tumor location and duration of presenting symptoms remain poorly characterized in children. PROCEDURE: We retrospectively reviewed neurologic impairments in 246 pediatric patients with LGGs (88 with optic pathway and midline tumors, 56 with posterior fossa tumors, 52 with cerebral hemisphere tumors, 35 with brainstem tumors, and 15 with spinal cord tumors) who were treated at St. Jude Children's Research Hospital between 1995 and 2005...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29730270/management-of-iatrogenic-spinal-cerebrospinal-fluid-leaks-a-cohort-of-124-patients
#11
Royce W Woodroffe, Kirill V Nourski, Logan C Helland, Brian Walsh, Jennifer Noeller, Panagiotis Kerezoudis, Patrick W Hitchon
OBJECTIVES: Cerebrospinal fluid leaks are a frequent complication of spinal surgery, with reported rates between 2 and 20%. Management is highly variable and dependent on comorbidities, complexity of the index procedure, and surgeons' experience. Treatment options include primary or delayed repair, with or without spinal drainage. Using a retrospective cohort, the authors aim to identify the appropriate management of iatrogenic spinal cerebrospinal fluid (CSF) leaks. PATIENTS AND METHODS: We queried our institutional database for postoperative spinal CSF leaks between 1/1/2007 and 3/14/2017 using Current Procedural Terminology (CPT) and International Classification of Disease (ICD) codes...
April 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29726777/surgical-outcomes-after-reoperation-for-recurrent-skull-base-meningiomas
#12
Stephen T Magill, David S Lee, Adam J Yen, Calixto-Hope G Lucas, David R Raleigh, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
OBJECTIVE Skull base meningiomas are surgically challenging tumors due to the intricate skull base anatomy and the proximity of cranial nerves and critical cerebral vasculature. Many studies have reported outcomes after primary resection of skull base meningiomas; however, little is known about outcomes after reoperation for recurrent skull base meningiomas. Since reoperation is one treatment option for patients with recurrent meningioma, the authors sought to define the risk profile for reoperation of skull base meningiomas...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29712574/durable-regression-of-medulloblastoma-after-regional-and-intravenous-delivery-of-anti-her2-chimeric-antigen-receptor-t-cells
#13
Anandani Nellan, Christopher Rota, Robbie Majzner, Cynthia M Lester-McCully, Andrea M Griesinger, Jean M Mulcahy Levy, Nicholas K Foreman, Katherine E Warren, Daniel W Lee
BACKGROUND: Standard-of-care therapies for treating pediatric medulloblastoma have long-term side effects, even in children who are cured. One emerging modality of cancer therapy that could be equally effective without such side effects would be chimeric antigen receptor (CAR) T cells. Knowing that human epidermal growth factor receptor 2 (HER2) is overexpressed in many medulloblastomas and has been used as a CAR T target before, we sought to evaluate the efficacy of more sophisticated anti-HER2 CAR T cells, as well as the feasibility and efficacy of different routes of delivering these cells, for the treatment of pediatric medulloblastoma...
April 30, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29707472/bilateral-supratentorial-subdural-hematomas-after-craniotomy-for-posterior-fossa-tumor-removal
#14
Aikaterini Solomou, Pantelis Kraniotis, George Bonanos, Constantine Constantoyannis
A 69-year-old man was admitted to the emergency department with headache and dizziness. He was submitted to brain computed tomography (CT) which showed a tumor in the right cerebellar hemisphere, findings which were subsequently confirmed with magnetic resonance imaging (MRI). He underwent a paramedian suboccipital craniotomy for removal of the mass. Histology confirmed the presence of a hemangiopericytoma. The patient was discharged 5 days postoperatively with improvement in his symptoms. Fifteen days later, he presented with gait difficulties...
April 2018: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/29706825/medulloblastoma-in-a-toddler-with-gorlin-syndrome
#15
Mohamad G Al-Rahawan, Sorleen Trevino, Roy Jacob, Jeffrey C Murray, Mohamad M Al-Rahawan
Gorlin syndrome (GS) is a rare hereditary multisystem disorder caused by mutations in PTCH1, PTCH2 , or SUFU . It is characterized by multiple anomalies and an increased risk of developing various tumors. Basal cell carcinoma is most common, and medulloblastoma (MB) is especially frequent in patients with SUFU mutations. MB treatment often includes radiation therapy in patients older than 3 years; however, such treatment is very toxic to patients with GS. Most reported cases of MB in patients with GS present after GS is diagnosed...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29704232/prognostic-and-microrna-profile-analysis-for-cd44-positive-expression-pediatric-posterior-fossa-ependymoma
#16
C Shu, Q Wang, X Yan, J Wang
BACKGROUND: Ependymoma is the third most common pediatric brain tumor and occurs most frequently in the posterior fossa. However, the lack of immortalized cell lines, xenografts, or animal models has significantly hindered the study of pediatric posterior fossa ependymoma (P-PF-EPN) pathogenesis. This prompted us to use clinical big data to study this rare disease. METHODS: Application of the robust rank aggregation method revealed CD44 as a reliable biomarker in P-PF-EPN...
April 27, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29701558/syringobulbia-in-pediatric-patients-with-chiari-malformation-type-i
#17
Arnold H Menezes, Jeremy D W Greenlee, Brian J Dlouhy
OBJECTIVE Syringobulbia (SB) is a rare entity, with few cases associated with Chiari malformation type I (CM-I) in the pediatric population. The authors reviewed all pediatric cases of CM-I-associated SB managed at their institution in order to better understand the presentation, treatment, and surgical outcomes of this condition. METHODS A prospectively maintained institutional database of craniovertebral junction abnormalities was analyzed to identify all cases of CM-I and SB from the MRI era (i.e., after 1984)...
April 27, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29701550/brain-invasion-and-the-risk-of-seizures-in-patients-with-meningioma
#18
Katharina Hess, Dorothee Cäcilia Spille, Alborz Adeli, Peter B Sporns, Caroline Brokinkel, Oliver Grauer, Christian Mawrin, Walter Stummer, Werner Paulus, Benjamin Brokinkel
OBJECTIVE Identification of risk factors for perioperative epilepsy remains crucial in the care of patients with meningioma. Moreover, associations of brain invasion with clinical and radiological variables have been largely unexplored. The authors hypothesized that invasion of the cortex and subsequent increased edema facilitate seizures, and they compared radiological data and perioperative seizures in patients with brain-invasive or noninvasive meningioma. METHODS Correlations of brain invasion with tumor and edema volumes and preoperative and postoperative seizures were analyzed in univariate and multivariate analyses...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29686816/evaluation-of-the-prognostic-value-of-multimodal-intraoperative-monitoring-in-posterior-fossa-surgery-patients-with-cerebellopontine-angle-tumors
#19
Mohsen Dalvandi, Ali Nazemi Rafie, Alireza Kamali, Alireza Jamshidifard
The aim of this study was to compare the outcomes of four intraoperative monitoring approaches in order to compare their prognostic value in surgical complications of the facial nerve. This quasi-experimental study was conducted on 25 patients with Cerebellopontine Angle (CPA) tumors, who were hospitalized in the Valiasr Hospital, affiliated to the Arak University of Medical Sciences, Arak, Iran. The degree of the facial nerve paralysis was assessed based on the House-Brackmann (HB) facial nerve grading system...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29684637/reconstruction-of-condyles-by-transport-distraction-osteogenesis-3-case-report-with-complication-management
#20
Dogan Dolanmaz, Kayhan Ozturk, Mehmet Bahadir Llik, Murat Celik
OBJECTIVE: The aim of this case report is to evaluate the clinical outcomes that including minor postoperative complications of the transport distraction osteogenesis (TDO) for reconstruction of the ramus-condyle unit. STUDY DESIGN: We present 3 cases of the ramus condyle unit reconstruction after the resection of bone tumors. All three bone tumors were excised intraoperatively and the histologic assessment confirmed the clinical diagnosis of osteochondroma, condylar hyperplasia and osteoma...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
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