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Posterior fossa tumors

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https://www.readbyqxmd.com/read/29143922/pre-treatment-lymphopenia-and-indication-of-tumor-induced-systemic-immunosuppression-in-medulloblastoma
#1
Seema Patel, Shiyang Wang, Matija Snuderl, Matthias A Karajannis
The presence of tumor-induced systemic immune suppression, including lymphopenia, has been recognized in adult patients with glioblastoma for several decades, and pre-treatment neutrophil-to-lymphocyte count ratio (NLCR) is associated with inferior clinical outcome in patients with glioblastoma. Whether tumor-induced systemic immune suppression is also present in children with malignant brain tumors is not known. We performed a retrospective analysis of pretreatment neutrophil and lymphocyte counts in pediatric patients with medulloblastoma (MB) compared to a control group of children with posterior fossa pilocytic astrocytoma (PA)...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29116485/prevalence-risk-factors-and-response-to-treatment-for-hypersomnia-of-central-origin-in-survivors-of-childhood-brain-tumors
#2
Raja B Khan, Thomas E Merchant, Zsila S Sadighi, Mercedes S Bello, Zhaohua Lu, April Sykes, Merrill S Wise, Valerie M Crabtree, Jennifer Zabrowski, Andrea Simmons, Mary E Clark, Belinda N Mandrell
Daytime sleepiness is recognized in childhood brain tumor survivors. Our objective was to determine prevalence, risk factors for PSG/MLST proven hypersomnia/narcolepsy, and response to stimulants in childhood brain tumor survivors. Standard PSG/MSLT criteria were used to diagnose hypersomnia/narcolepsy. Medical records of brain tumor survivors having undergone a PSG/MSLT were reviewed for the diagnostic code of hypersomnia/narcolepsy. Survivors with hypersomnia/narcolepsy were matched with 2-3 survivors without reported hypersomnia/narcolepsy by age at tumor diagnosis, gender, and time from tumor diagnosis...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29114295/tumor-recurrence-in-a-glioblastoma-patient-after-discontinuation-of-prolonged-temozolomide-treatment
#3
Wei-Lung Tseng, Hsu-Hsien Hsu, Yun Chen, Sheng-Hong Tseng
There is no consensus regarding the duration of temozolomide (TMZ) treatment for glioblastoma multiforme (GBM). We report a 53-year-old woman who had a left frontal GBM. The tumor showed good response to TMZ treatment, which was discontinued after 5.5 years with recurrence of tumor at the posterior fossa 6 months later, although there was no definite tumor recurrence in the left frontal region. The tumor failed to respond to the reinstitution of TMZ therapy. Continuous TMZ treatment may be necessary in GBM patients on prolonged TMZ treatment despite improved neurological condition and imaging studies revealing marked tumor regression...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29114284/intraoperative-magnetic-resonance-imaging-for-cranial-and-spinal-cases-using-preexisting-c-shaped-three-side-open-0-2-tesla-magnetic-resonance-imaging
#4
Vinod Kumar Tewari, Ravindra Tripathi, Subodh Aggarwal, Mazhar Hussain, Hari Kishan Das Gupta
Background: The existing Intraoperative MRI (IMRI) of developed countries is too costly to be affordable in any developing country and out of the reach of common and poor people of developing country at remote areas. We have used the pre-existing (refurbished) 3 side open "C" shaped 0.2 Tesla MRI for IMRI in a very remote area. Materials and Methods: In this technique the 0.2 Tesla MRI and the operating theatre were merged. MRI table was used as an operation table...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29101614/visual-outcome-after-endoscopic-third-ventriculostomy-for-hydrocephalus
#5
Ji-Ho Jung, Yong-Hyun Chai, Shin Jung, In-Young Kim, Woo-Youl Jang, Kyung-Sub Moon, Seul-Kee Kim, Sangjoon Chong, Seung-Ki Kim, Tae-Young Jung
PURPOSE: Hydrocephalus-related symptoms are mostly improved after successful endoscopic third ventriculostomy (ETV). However, visual symptoms can be different. This study was focused on visual symptoms. We analyzed the magnetic resonance images (MRI) of the orbit and visual outcomes. METHODS: From August 2006 to November 2016, 50 patients with hydrocephalus underwent ETV. The male-to-female ratio was 33:17, and the median age was 61 years (range, 5-74 years). There were 18 pediatric and 32 adult patients...
November 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29099350/letter-to-the-editor-posterior-fossa-tumor-resection-and-the-failure-of-endoscopic-third-ventriculostomy-and-ventriculoperitoneal-shunts
#6
Chiazor U Onyia
No abstract text is available yet for this article.
November 3, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29076464/-extended-endoscopic-endonasal-posterior-transclival-approach-to-tumors-of-the-clival-region-and-ventral-posterior-cranial-fossa-part-2-topographic-and-anatomical-aspects-and-surgical-technique
#7
A N Shkarubo, K V Koval', G F Dobrovol'skiy, M A Shkarubo, G A Polev, D N Andreev, I V Chernov, V V Karnaukhov, O A Gadzhieva
PURPOSE: to present the main topographic and anatomical features of the clivus and adjacent structures for improving and optimizing the extended endoscopic transnasal posterior (transclival) approach in removal of clival and ventral posterior cranial fossa lesions. MATERIAL AND METHODS: We performed a topographic and anatomical study of 25 cadaver heads, the vascular bed of which was filled with colored silicone using the original technique for visualizing the bed features and individual variability...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29075584/subarachnoid-hemorrhage-associated-with-intratumoral-aneurysm-rupture-within-a-posterior-fossa-hemangioblastoma-the-importance-of-continued-surveillance-for-cerebral-vasospasm
#8
Connie Ju, Christina H Wright, James Wright, Yifei Duan, Nicholas C Bambakidis
Cerebellar hemangioblastomas are rare tumors of the neuraxis. Only seven cases of hemangioblastoma associated with a cerebral aneurysm have been reported. We report a case of a patient who presented with acute onset headache as a result of subarachnoid hemorrhage (SAH) and hydrocephalus. Radiographic workup revealed a hemangioblastoma with an intratumoral aneurysm. Preoperative cerebral angiography was performed for both embolization as well as characterization of the aneurysm. The patient underwent a suboccipital craniotomy for tumor resection...
August 24, 2017: Curēus
https://www.readbyqxmd.com/read/29074422/suboccipital-craniotomy-versus-craniectomy-a-survey-of-practice-patterns
#9
Elizabeth N Kuhn, Gustavo Chagoya, Bonita S Agee, Mark R Harrigan
OBJECT: Open surgical access to the posterior fossa has traditionally been achieved by permanent bone removal and remains the mainstay of posterior fossa surgery, although craniotomy is an alternative. Considerable variation exists at both the national and international levels within a variety of neurological and neurosurgical disciplines. In this study we surveyed current practice patterns regarding preference of suboccipital craniotomy or craniectomy. METHODS: The membership directory of the American Academy of Neurological Surgeons (AANS) was reviewed...
October 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29067507/non-surgical-transient-cerebellar-mutism-case-report-and-systematic-review
#10
Serge Makarenko, Navneet Singh, Patrick J McDonald
INTRODUCTION: Transient cerebellar mutism has been well recognized in literature as a complication of posterior fossa tumor resection. It is marked by profound impairment of fluency, articulation, and modulation of speech, irritability and autistic features and typically resolves within days to months. Underlying pathophysiology is debated, but currently unknown. METHODS: We present a case of a child with similar clinical findings after cerebellitis, demonstration of diffuse cerebellar signal changes, swelling, and protruding tonsils at the level of foramen magnum...
October 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29062268/comparison-of-diffusion-weighted-mri-reconstruction-methods-for-visualization-of-cranial-nerves-in-posterior-fossa-surgery
#11
Brendan Behan, David Q Chen, Francesco Sammartino, Danielle D DeSouza, Erika Wharton-Shukster, Mojgan Hodaie
Diffusion-weighted imaging (DWI)-based tractography has gained increasing popularity as a method for detailed visualization of white matter (WM) tracts. Different imaging techniques, and more novel, advanced imaging methods provide significant WM structural detail. While there has been greater focus on improving tract visualization for larger WM pathways, the relative value of each method for cranial nerve reconstruction and how this methodology can assist surgical decision-making is still understudied. Images from 10 patients with posterior fossa tumors (4 male, mean age: 63...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29061299/challenges-and-recent-advances-in-medulloblastoma-therapy
#12
REVIEW
Vinod Kumar, Virender Kumar, Timothy McGuire, Donald W Coulter, John G Sharp, Ram I Mahato
Medulloblastoma (MB) is the most common childhood brain tumor, which occurs in the posterior fossa. MB tumors are highly heterogeneous and have diverse genetic make-ups, with differential microRNA (miRNA) expression profiles and variable prognoses. MB can be classified into four subgroups, each with different origins, pathogenesis, and potential therapeutic targets. miRNA and small-molecule targeted therapies have emerged as a potential new therapeutic paradigm in MB treatment. However, the development of chemoresistance due to surviving cancer stem cells and dysregulation of miRNAs remains a challenge...
October 20, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29059949/application-of-mri-texture-analysis-in-the-study-of-the-posterior-fossa-tumors-growing-trend-in-children
#13
Mengmeng Li, Zhigang Shang, Yonghui Dong, Yong Zhang, Ya Li
In order to analyze the growing trend of the posterior fossa tumor in children and provide assistant basis for the treatment or surgery of tumors, a variety of texture analysis methods were comprehensive used to analyze and identify three kinds of brain tissues, tumor region, tumor diffusion region and normal brain tissue region. The MRIs of tumor patients were collected to extract texture features. Then feature selection method CFS and feature compression method partial least squares regression (PLSR) were used to process these feature space...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054779/prevalence-characteristics-and-long-term-prognosis-of-epilepsy-associated-with-pediatric-brain-tumors
#14
Hadar Weisman, Iris Fried, Tal Gilboa, Odeya Bennett-Back, Dana Ekstein, Moatasem Shweiki, Yigal Shoshan, Mony Benifla
OBJECTIVE: We investigated the prevalence, onset, characteristics and long-term course of epilepsy disease in children who underwent surgical intervention for diagnosed brain tumors. METHODS: We reviewed the medical records of children with diagnosed brain tumors, who underwent surgery during 2004-2014 at the Hadassah Medical Center. All patients with epilepsy were invited to a clinical visit that included a neurological exam. The primary outcome measures were neurological status according to the Glasgow Outcome Scale (GOS) and postoperative seizure outcome according to the Engel system...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29045264/patterns-of-failure-in-patients-with-adult-medulloblastoma-presenting-without-extraneural-metastasis
#15
Meriem Mokhtech, Christopher G Morris, Daniel J Indelicato, Michael S Rutenberg, Robert J Amdur
OBJECTIVES: The objective of this study is to evaluate long-term outcomes, specifically patterns of tumor recurrence, in patients with adult medulloblastoma treated with radiotherapy. METHODS: We recorded outcomes of 28 (median age, 25 y) patients 18 years old or above with M0 to M3 medulloblastoma treated between 1971 and 2012. Among them, 61% had standard-risk disease. All received craniospinal irradiation with a posterior fossa boost. Median dose to the craniospinal axis was 36 Gy...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29027018/accelerated-growth-of-hemangioblastoma-in-pregnancy-the-role-of-proangiogenic-factors-and-upregulation-of-hypoxia-inducible-factor-hif-in-a-non-oxygen-dependent-pathway
#16
REVIEW
Yosef Laviv, Joshua L Wang, Matthew P Anderson, Ekkehard M Kasper
Hemangioblastomas (HBs) are benign, highly vascular tumors, often characterized by loss of function of the von Hippel-Lindau (vHL) gene. They are the most common central nervous system tumor observed in vHL syndrome. Loss of function of the vHL gene creates a "pseudo-hypoxic" state, causing overactivation of hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF)-related pathways. In some cases, HBs can rapidly increase in size during pregnancy to then present acutely, which most frequently occurs after the 20th gestational week...
October 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29026675/advantages-of-using-a-detachable-tip-microcatheter-and-liquid-embolic-agents-in-the-preoperative-embolization-of-a-recurrent-cerebellar-hemangioblastoma-a-case-report
#17
Nicolas Yanez, Luisa K Cifuentes, Marcela Mejia, Juan N Useche
BACKGROUND: The preferred treatment for intracranial hemangioblastomas is surgical resection with or without preoperative embolization, however, embolization remains controversial due to risks such as distal tip entrapment, vascular injury during navigation, and embolic agent migration. CASE DESCRIPTION: A 54-year-old woman was admitted for surgical resection and preoperative embolization of a cerebellar hemangioblastoma. Although experience using Onyx with detachable and nondetachable tip microcatheters has been well reported in a variety of clinical circumstances, we describe the first case of a presurgical embolization of an intra-axial tumor using a second-generation detachable-tip microcatheter and a nonadhesive liquid embolic agent...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28986231/microsphere-embolization-of-hypervascular-posterior-fossa-tumors-a-technical-note
#18
Oluwaseun O Akinduro
BACKGROUND: Preoperative embolization of highly vascular tumors of the posterior fossa can decrease morbidity and operative blood loss. No clear consensus exists for the embolization agent of choice for optimal devascularization of these tumors. OBJECTIVE: The purpose of this analysis was to assess the effectiveness of microsphere embolization, in reducing tumor hypervascularity before surgical resection METHODS: We retrospectively reviewed medical records of patients with hypervascular posterior fossa tumors who were treated at a single institution from 2009 through 2016...
October 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28984116/cerebellar-liponeurocytoma-with-atypical-histological-features-a-rare-example-of-a-glioneuronal-tumor
#19
Blanka Hermann, Michal Woznica, Wojciech Kloc, Piotr Borkowski, Witold Libionka, Ewa Izycka-Swieszewska
We present a case of a rare neoplasm in a 77-year-old woman with previous oncological history, who developed a rapid onset of cerebellar symptoms. The neuroimaging detected a posterior fossa tumor suspected of meningioma which was completely resected soon after. Histologically the neoplasm had two components with different immunophenotype. One constituent was lobular, composed of monotonous mitotically active round cells with a predominant neuronal profile. The second, astrocytic component contained lipomatous cells intermixed with larger gemistocytic astrocytes...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28973649/dural-closure-in-confined-spaces-of-the-skull-base-with-nonpenetrating-titanium-clips
#20
Chad A Glenn, Cordell M Baker, Joshua D Burks, Andrew K Conner, Adam D Smitherman, Michael E Sughrue
BACKGROUND: Dural repair in areas with limited operative maneuverability has long been a challenge in skull base surgery. Without adequate dural closure, postoperative complications, including cerebrospinal fluid (CSF) leak and infection, can occur. METHODS: We reviewed 53 consecutive surgical patients in whom a dural repair technique utilizing titanium microclips was performed from 2013 to 2016 at our institution. The repairs primarily involved difficult-to-reach dural defects in which primary suturing was difficult or impractical...
July 25, 2017: Operative Neurosurgery (Hagerstown, Md.)
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