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Posterior fossa lymphoma

Yoshinobu Takahashi, Akimasa Nishio, Daisuke Yamamoto, Hajime Kamada, Naoya Hashimoto
BACKGROUND AND PURPOSE: Among adults with posterior fossa tumors, an intraaxial location of the tumor is less common than an extraaxial location. Moreover, the differential diagnosis of a single cerebellar tumor in adults is sometimes difficult by conventional magnetic resonance imaging. We aimed to report the findings of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) and methionine in adult patients with intraaxial and solitary metastatic brain tumors. MATERIALS AND METHODS: FDG-PET was performed on 12 patients with posterior fossa tumors: 4 had solid hemangioblastoma (HB), 3 had primary central nervous system lymphomas, 1 had a glioblastoma, and 4 had single metastatic brain tumors (METs)...
February 2018: World Neurosurgery
Moritaka Yamauchi, Tomohisa Okada, Tsutomu Okada, Akira Yamamoto, Yasutaka Fushimi, Yoshiki Arakawa, Susumu Miyamoto, Kaori Togashi
This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4...
August 2017: Medicine (Baltimore)
Jennifer A Kosty, Norberto Andaluz
BACKGROUND: Thymic epithelial tumors (TETs) are uncommon lesions, and cerebral metastases from these tumors are even rarer. We report a case of a posterior fossa metastasis in a patient with a known history of thymic carcinoma. CASE DESCRIPTION: A 47-year-old man with a history of Hodgkin lymphoma and thymic carcinoma presented with headache, nausea, and ataxia. Imaging revealed a large posterior fossa mass. This lesion was completely resected without complications...
September 2016: World Neurosurgery
Kazunori Kihara, Motoki Sato, Ken Kado, Kazumasa Fukuda, Takao Nakamura, Iwao Yamakami, Yasuo Iwadate
Primary dural lymphoma (PDL) is a rare type of primary central nervous system lymphoma (PCNSL); however, its clinical etiology and appearance on magnetic resonance images (MRI) are similar to those of meningioma. We report a case of PDL mimicking a meningioma in the jugular tubercle, with hemiparesis and double vision, and review the published PDL case reports. A 41-year-old woman experienced numbness on her right side, and reported right hemiparesis and double vision 2 days thereafter. Her cranial computed tomography (CT) scan showed a mass lesion in the posterior fossa, and contrasted MRI revealed homogenous tumor with a dural tail sign in the left jugular tubercle...
May 2016: No Shinkei Geka. Neurological Surgery
W Oliver Tobin, Fredric B Meyer, B Mark Keegan
OBJECTIVE: We aimed to determine the diagnostic yield and safety of posterior fossa parenchymal biopsy. METHODS: One-hundred-thirty-six patients who underwent 137 posterior fossa (brainstem or cerebellar) parenchymal biopsies at Mayo Clinic (Rochester, Minnesota, USA) between 1996 and 2009 were identified by chart review. Case histories; radiologic, surgical, and pathologic reports; and safety outcomes were assessed. RESULTS: Posterior fossa parenchymal biopsies were performed on 78 male and 58 female patients of median age 47 years (interquartile range 28-61)...
December 2015: World Neurosurgery
Huang-I Hsu, Ping-Hong Lai, Hui-Hwa Tseng, Shu-Shong Hsu
INTRODUCTION: Primary central nervous lymphoma(PCNSL) is a rare form of non-Hodgkin lymphoma confined to the central nervous system. Most of the lesions are supratentorial and periventricular, often involving deep structures such as corpus callosum and basal ganglion. Isolated intraventricular lymphoma is rare and only a few case reports. We report, to the best of our knowledge, the seventh case of isolated PCNSL in the fourth ventricle in an immunocompetent patient. PRESENTATION OF CASE: A 61-year-old male presenting with 3 months of headache and dizziness followed with unsteady gait for days...
2015: International Journal of Surgery Case Reports
Amanda M Li, Christopher Dunham, Uri Tabori, Anne-Sophie Carret, P Daniel McNeely, Donna Johnston, Lucie Lafay-Cousin, Beverly Wilson, David D Eisenstat, Nada Jabado, Shayna Zelcer, Mariana Silva, Katrin Scheinemann, Christopher Fryer, Glenda Hendson, Abbas Fotovati, Cynthia Hawkins, Stephen Yip, Sandra E Dunn, Juliette Hukin
BACKGROUND: The cure rate for childhood intracranial ependymoma is approximately 70% in the setting of a gross total resection followed by radiation, but management remains challenging in patients with residual disease. Therefore, robust biomarkers are needed to guide the development of new targeted therapy. The authors evaluated the expression of several biomarkers in pediatric intracranial ependymoma and observed that the expression of enhancer of zeste homolog 2 (EZH2), a polycomb complex protein involved in epigenetic regulation of gene expression, was independently associated with poor survival...
May 1, 2015: Cancer
V R N Gunness, A Hana, C Berthold, G Dooms, F Hertel
BACKGROUND: Toxoplasmosis is the most frequent opportunistic infection of the central nervous system among individuals with the acquired immunodeficiency syndrome. Radiographic modalities include brain CT, MRI and PET scan. The differential diagnosis are usually: primary CNS lymphoma, cerebral metastasis, Progressive multifocal leukoencephalopathy, cytomegalovirus. It indicates severe immunodeficiency and, if it remains untreated, it may lead to death. CASE DESCRIPTION: A 65 year old immunodeficiency woman with a Non Hodgkin Lymphoma treated with Chemotherapy...
2014: Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg
Asari Sai, Taro Shimono, Akira Yamamoto, Toru Takeshita, Masahiko Ohsawa, Kenichi Wakasa, Yukio Miki
INTRODUCTION: The aim of this study is to investigate the relationship between abnormal retropharyngeal lymph nodes (RPLNs) and sinonasal malignancies among adults. METHODS: Magnetic resonance and computed tomography images from 89 patients over 20 years old who were all histopathologically confirmed to have sinonasal malignancies from September 2001 to April 2014 were assessed retrospectively. Abnormal RPLNs were determined as those >5 mm in shortest axis or showing heterogeneous enhancement on axial images...
December 2014: Neuroradiology
Ju Wan Kang, Jeong Hong Kim
An 87-year-old man presented with a 1-week history of transient facial numbness, followed by the onset of left diplopia 1 month later. In the neurological examination, he was found to have left abducens nerve palsy. A brain MRI showed an infiltrative lesion invading the left posterior nasal cavity and pterygopalatine fossa, and extending into the left paracavernous region. The histological diagnosis was diffuse large B-cell lymphoma. We report an unusual case of diffuse large B-cell lymphoma occurring in the sinonasal tract with unilateral abducens nerve palsy presenting as an early feature...
November 2013: Journal of Craniofacial Surgery
Yukie Shimizu, Khin Khin Tha, Akihiro Iguchi, Yuko Cho, Atsushi Yoshida, Noriyuki Fujima, Akiko Tsukahara, Hiroki Shirato, Satoshi Terae
Posterior reversible encephalopathy syndrome (PRES) is characterized by reversible vasogenic edema affecting the subcortical white matter of bilateral occipital and parietal lobes. We describe a case of isolated posterior fossa involvement of PRES which occurred during remission induction chemotherapy for T-cell acute lymphoblastic leukemia. Both the brainstem and cerebellum were extensively involved, but the supratentorial structures were completely spared. The follow-up magnetic resonance images revealed reversibility of most lesions...
October 2013: Neuroradiology Journal
Rakan Bokhari, Ahmad Ghanem, Mahmoud Alahwal, Saleh Baeesa
Primary central nervous lymphoma (PCNSL) is a rare variant of extranodal non-Hodgkin's lymphoma with a especially poor prognosis. The diagnosis is usually encountered in immunodeficient patients but is also encountered, albeit uncommonly, in the immunocompetent. We present a 50-year-old male who developed signs and symptoms of increased intracranial pressure. Imaging revealed the presence of a fourth ventricle mass with obstructive hydrocephalus. First, the patient underwent emergency endoscopic third ventriculostomy followed, few days later, by complete tumor resection via a posterior fossa craniotomy...
2013: Case Reports in Oncological Medicine
Philippe Métellus, Thierry Faillot, Jacques Guyotat, Walid Farah, Luc Bauchet, Françoise Mornex, Philippe Menei
Surgical excision in brain metastases has been well evaluated in unique metastases. Two randomized phase III trials have shown that combined with adjuvant whole brain radiotherapy, it significantly improves overall survival. However, even in the presence of multiple brain metastases, surgery may be useful in large, symptomatic or life-threatening lesions (posterior fossa tumor with mass effect). Also, even in lesions amenable to radiosurgery, surgical resection is preferred when tumors displayed cystic or necrotic aspect with important edema or when located in highly eloquent areas or cortico-subcortically...
January 1, 2013: Bulletin du Cancer
Gloria von Geldern, Carlos A Pardo, Peter A Calabresi, Scott D Newsome
A 38-year-old woman was diagnosed with cutaneous anaplastic T-cell lymphoma that proved refractory to methotrexate, bexarotene, denileukin diftitox, interferon γ-1b, interferon α-2b, vorinostat, and pralatrexate. She was therefore started on the newly approved monoclonal anti-CD30 antibody brentuximab vedotin. Treatment with brentuximab 1.8 mg/kg IV every 3 weeks quickly led to disappearance of her cutaneous tumors. The day after her second brentuximab infusion she developed word-finding difficulties and unsteady gait...
November 13, 2012: Neurology
Tom Sutherland, Kelvin Yap, Elaine Liew, Con Tartaglia, Mai Pang, Nicholas Trost
INTRODUCTION: To define the features of primary central nervous system lymphoma (PCNSL) on MRI in immunocompetent patients. METHODS: A retrospective review of the authors' institutional database was performed to identify histologically proven cases of PCNSL. Images were retrieved and reviewed with respect to location, lesion number, size, signal intensity, enhancement characteristics, oedema and necrosis. RESULTS: Thirty-one cases of histologically proven PCNSL had available imaging...
June 2012: Journal of Medical Imaging and Radiation Oncology
Akira Yokote, Yoshio Tsuboi, Kousuke Fukuhara, Jun Tsugawa, Hirosato Inoue, Mikiko Aoki, Kazuki Nabeshima, Hitoshi Tsugu, Toru Inoue, Tatsuo Yamada
Bilateral abducens nerve palsy is an unusual clinical presentation, which could be caused by stroke, aneurysm, trauma and malignant neoplasm. We describe here a patient with bilateral abducens nerve palsy caused by large B cell lymphoma originated from clivus. An 83-year-old woman admitted to our hospital because of diplopia and severe posterior neck pain. Her diplopia developed one month before and progressed to her admission. Neurological examination revealed bilateral abducens nerve palsy. Brain MRI with enhancement lesion in the clivus, suggesting that bilateral petroclival segment of the abducens nerves were affected by the lesion...
2012: Rinshō Shinkeigaku, Clinical Neurology
Atsushi Kuge, Shinya Sato, Kaori Sakurada, Sunao Takemura, Takamasa Kayama
Atypical teratoid rhabdoid tumor (AT/RT) is a rare entity. In the central nervous system, AT/RT generally arises from the posterior fossa of infants and behaves aggressively. AT/RT is reported to arise from the infratentorial region (63%) and other sites, such as the suprasellar region, cerebellopontine angle, and spinal cord. The pineal region is rare (6%) as a site of origin. Radiation-induced brain tumors are well known. In this report, we present a case of a pineal region tumor causing acute hydrocephalus that could be pathologically diagnosed as AT/RT following prophylactic cranial irradiation for acute lymphoblastic leukemia...
July 2012: Brain Tumor Pathology
Stefan Grau, Ulrich Schueller, Carolin Weiss, Jörg-Christian Tonn
BACKGROUND: Most primary lymphomas of the central nervous system (CNS) are of B-cell origin and are found intra-axially, with a few reported cases of skull base tumors involving the upper clivus or sellar region or both. In this case, a tumor resembling a clivus meningioma without osseous involvement was surgically removed and turned out to be a primary T-cell lymphoma. CASE REPORT: A 60-year-old woman presented with slight right-sided abducens nerve palsy. Cranial imaging revealed an extra-axial mass at the caudal clivus resembling a meningioma...
October 2010: World Neurosurgery
V Tronnier, G Pannier, S Gottschalk, D Petersen, E Reusche, H Merz
UNLABELLED: We present an unusual case of a patient with trigeminal pain and hypesthesia suggesting trigeminal schwannoma, where histology demonstrated an inflammatory lesion of the Gasserian ganglion. CLINICAL PRESENTATION: Patient history and imaging were typical for a trigeminal schwannoma with a dumbbell growth in the middle and posterior fossa. Surgery was performed and resection of a firm mass intermingled with fascicles originating from the ganglion and the mandibular branch was carried out via a subtemporal approach...
May 2010: Central European Neurosurgery
Shiro Baba, Takayuki Matsuo, Shunsuke Ishizaka, Minoru Morikawa, Kazuhiko Suyama, Izumi Nagata
Granulocytic sarcoma consists of neoplastic granulocytic precursors and myeloblasts. It is a focal lesion seen in 2-10.9% of acute myelogenous leukaemia (AML) patients. It usually develops either concurrently with the AML or after a remission. On rare occasions, it may be an initial manifestation of AML. Most common involvement sites are bone, periostium, soft tissue, lymph nodes and skin. Intracranial granulocytic sarcoma rarely occurs in meningeal or parenchymal form. We present an extremely rare case of intracranial granulocytic sarcoma extending from the posterior fossa to the carotid space via the jugular foramen in a 69 year old female...
January 2010: No Shinkei Geka. Neurological Surgery
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