Cynthia Owsley, Gerald McGwin, Thomas A Swain, Mark E Clark, Tracy N Thomas, Lukas Goerdt, Kenneth R Sloan, Emily H Trittschuh, Yu Jiang, Julia P Owen, Cecilia S Lee, Christine A Curcio
PURPOSE: Research on Alzheimer's disease (AD) and precursor states demonstrates a thinner retinal nerve fiber layer (NFL) compared to age-similar controls. Because AD and age-related macular degeneration (AMD) both impact older adults and share risk factors, we asked if retinal layer thicknesses, including NFL, are associated with cognition in AMD. METHODS: Adults ≥ 70 years with normal retinal aging, early AMD, or intermediate AMD per Age-Related Eye Disease Study (AREDS) nine-step grading of color fundus photography were enrolled in a cross-sectional study...
May 1, 2024: Investigative Ophthalmology & Visual Science