keyword
MENU ▼
Read by QxMD icon Read
search

PIV

keyword
https://www.readbyqxmd.com/read/29157863/structure-activity-relationship-study-of-aib-containing-amphipathic-helical-peptide-cyclic-rgd-conjugates-as-carriers-for-sirna-delivery
#1
Shun-Ichi Wada, Anna Takesada, Yurie Nagamura, Eri Sogabe, Rieko Ohki, Junsuke Hayashi, Hidehito Urata
The conjugation of Aib-containing amphipathic helical peptide with cyclo(-Arg-Gly-Asp-d-Phe-Cys-) (cRGDfC) at the C-terminus of the helix peptide (PI) has been reported to be useful for constructing a carrier for targeted siRNA delivery into cells. In order to explore structure-activity relationships for the development of potential carriers for siRNA delivery, we synthesized conjugates of Aib-containing amphipathic helical peptide with cRGDfC at the N-terminus (PII) and both the N- and C-termini (PIII) of the helical peptide...
November 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29157142/experimental-study-on-centerline-velocities-of-a-rectangular-capture-hood-under-realistic-conditions
#2
Xinjian He, Braxton V Lewis, Steven E Guffey
Capture hoods are an important component of a local ventilation system designed to reduce exposures to airborne contaminants. The velocity at any point along the centerline of the hood (Vx) is currently estimated using one of many predictive equations developed since the 1930's. It is unproven that those predictive equations for Vx are accurate, despite the prodigious number of studies concerning them. Among other issues, almost all experimental verifications were conducted for conditions that were either unrealistically ideal without competing air currents (e...
November 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29148768/the-cyanopivaloyl-ester-in-the-automated-solid-phase-synthesis-of-oligorhamnans
#3
Anne Geert Volbeda, Jeanine van Mechelen, Nico Meeuwenoord, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
The development of effective protecting group chemistry is an important driving force behind the progress in the synthesis of complex oligosaccharides. Automated solid phase oligosaccharide synthesis is an attractive technique for the rapid assembly of oligosaccharides build up of repetitive elements. The fact that (harsh) reagents are used in excess in multiple reaction cycles make this technique extra demanding on the protecting groups used. Here, the synthesis of a set of oligorhamnan fragments is reported using the cyanopivaloyl (PivCN) ester, to ensure effective neighboring group participation during the glycosylation events...
November 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29131644/simultaneous-introduction-of-two-nitroxides-in-the-reaction-a-new-approach-to-the-synthesis-of-heterospin-complexes
#4
Victor Ovcharenko, Olga Kuznetsova, Elena Fursova, Gleb Letyagin, Galina Romanenko, Artem Bogomyakov, Ekaterina Zueva
A new approach to the synthesis of multispin compounds has been developed, namely, the simultaneous introduction of two different stable nitroxides (nitronyl nitroxide and imino nitroxide) in a reaction with a metal ion. An important characteristic of the new method is that nitronyl nitroxide and imino nitroxide introduced in the reaction with the metal are the products of different series; i.e., the nitronyl nitroxide molecule differs from the imino nitroxide molecule not only in one additional oxygen molecule per molecule but also in another substituent in the side chain of the organic paramagnet...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29124548/development-of-an-experimental-and-digital-cardiovascular-arterial-model-for-transient-hemodynamic-and-postural-change-studies-a-preliminary-framework-analysis
#5
Rodward L Hewlin, John P Kizito
The ultimate goal of the present work is to aid in the development of tools to assist in the treatment of cardiovascular disease. Gaining an understanding of hemodynamic parameters for medical implants allow clinicians to have some patient-specific proposals for intervention planning. In the present work an experimental and digital computational fluid dynamics (CFD) arterial model consisting of a number of major arteries (aorta, carotid bifurcation, cranial, femoral, jejunal, and subclavian arteries) were fabricated to study: (1) the effects of local hemodynamics (flow parameters) on global hemodynamics (2) the effects of transition from bedrest to upright position (postural change) on hemodynamics, and (3) diffusion of dye (medical drug diffusion simulation) in the arterial system via experimental and numerical techniques...
November 9, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29115357/measuring-biotherapeutic-viscosity-and-degradation-on-chip-with-particle-diffusometry
#6
K N Clayton, D Lee, S T Wereley, T L Kinzer-Ursem
In the absence of efficient ways to test drug stability and efficacy, pharmaceuticals that have been stored outside of set temperature conditions are destroyed, often at great cost. This is especially problematic for biotherapeutics, which are highly sensitive to temperature fluctuations. Current platforms for assessing the stability of protein-based biotherapeutics in high throughput and in low volumes are unavailable outside of research and development laboratories and are not efficient for use in production, quality control, distribution, or clinical settings...
November 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29102273/hemodynamic-assessment-of-extra-cardiac-tricuspid-valves-using-particle-image-velocimetry
#7
Munirah Ismail, Foad Kabinejadian, Yen Ngoc Nguyen, Edgar Tay Lik Wui, Sangho Kim, Hwa Liang Leo
There has not been much progress in the development of transcatheter tricuspid valves to treat tricuspid regurgitation because of the difficulty in anchoring a stented valve onto the complex tricuspid annulus. Hence, the concept of heterotopic implantation of the transcatheter tricuspid valve onto the cavo-atrial junction was proposed. However, to date there has been no detailed in vitro investigation of the hemodynamic performance of this new device. The study utilises both 2-D and 3-D particle image velocimetry (PIV) to interrogate the flow patterns in the vicinity of the extra-cardiac tricuspid valves in an in vitro physiological flow loop, specifically at four measurement locations in the cavo-atrial anatomy...
December 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29095180/a-randomized-double-blind-trial-to-determine-if-vapocoolant-in-the-adult-population-improves-patient-perception-of-pain-with-peripheral-intravascular-access
#8
Courtney Edwards, Christina Noah
The purpose of this study was to investigate whether the use of a topical anesthetic spray (vapocoolant) at the site of intravenous access reduces pain and anxiety associated with peripheral intravenous (PIV) catheter insertion in an adult emergency department population. A randomized, double-blind, placebo-controlled, single-center trial, conducted from July to August, in an adult emergency department where 72 patients with orders for PIV insertion receiving either topical vapocoolant spray (n = 38) or placebo spray (n = 34)...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29093083/dynamics-of-sendai-virus-spread-clearance-and-immunotherapeutic-efficacy-after-hematopoietic-cell-transplant-imaged-non-invasively-in-mice
#9
Heba H Mostafa, Peter Vogel, Ashok Srinivasan, Charles J Russell
There are no approved vaccines or virus-specific treatments for human parainfluenza viruses (PIVs), which have recently been reclassified into species human respirovirus 1 and 3 and human rubulavirus 2 and 4 These viruses cause morbidity and mortality in immunocompromised patients including those undergoing hematopoietic cell transplant (HCT). No small-animal models exist for non-invasive imaging of respiratory viral infection in the HCT host despite the utility such a system would offer to monitor prolonged infection, its clearance, and treatment options...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29082600/analysis-of-left-ventricular-fluid-dynamics-in-dilated-cardiomyopathy-by-echocardiographic-particle-image-velocimetry
#10
Chouchou Tang, Yizhong Zhu, Jing Zhang, Chengcheng Niu, Dan Liu, Yacong Liao, Lijun Zhu, Qinghai Peng
OBJECTIVE: The aim was to analyze left ventricular (LV) fluid dynamics in dilated cardiomyopathy (DCM) by using echocardiographic particle image velocimetry (E-PIV). METHODS: Twenty patients with DCM and twenty healthy volunteers were examined. LV ultrasound contrast was administered by intravenous bolus injection. At least three dynamic contrast-enhanced echocardiographic images of cardiac cycles from apical three-chamber view and four-chamber view were obtained...
October 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/29073316/observational-study-of-peripheral-intravenous-catheter-outcomes-in-adult-hospitalized-patients-a-multivariable-analysis-of-peripheral-intravenous-catheter-failure
#11
Nicole Marsh, Joan Webster, Emily Larson, Marle Cooke, Gabor Mihala, Claire M Rickard
BACKGROUND: Almost 70% of hospitalized patients require a peripheral intravenous catheter (PIV), yet up to 69% of PIVs fail prior to completion of therapy. OBJECTIVE: To identify risk factors associated with PIV failure. DESIGN: A single center, prospective, cohort study. SETTING: Medical and surgical wards of a tertiary hospital located in Queensland, Australia. PARTICIPANTS: Adult patients requiring a PIV...
October 18, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29049327/characteristics-of-pulsatile-flows-in-curved-stenosed-channels
#12
Hyeonji Hong, Eunseop Yeom, Ho Seong Ji, Hyun Dong Kim, Kyung Chun Kim
Spatial and temporal variations of the hemodynamic features occur under pulsatile conditions in complex vessel geometry. Wall shear stress affected by the disturbed flow can result in endothelial cell dysfunction, which leads to atherogenesis and thrombosis. Therefore, detailed understanding of the hemodynamic characteristics in a curved stenosed channel is highly important when examining the pathological effects of hemodynamic phenomena on the progression of atherosclerosis. The present study measures the velocity fields of pulsatile flows with three different Reynolds numbers in 3D curved vessel models with stenosis using time-resolved particle image velocimetry (PIV)...
2017: PloS One
https://www.readbyqxmd.com/read/29026342/flow-visualization-over-a-thick-blunt-trailing-edge-airfoil-with-base-cavity-at-low-reynolds-numbers-using-piv-technique
#13
Gholamhossein Taherian, Mahdi Nili-Ahmadabadi, Mohammad Hassan Karimi, Mohammad Reza Tavakoli
ABSTRACT: In this study, the effect of cutting the end of a thick airfoil and adding a cavity on its flow pattern is studied experimentally using PIV technique. First, by cutting 30% chord length of the Riso airfoil, a thick blunt trialing-edge airfoil is generated. The velocity field around the original airfoil and the new airfoil is measured by PIV technique and compared with each other. Then, adding two parallel plates to the end of the new airfoil forms the desired cavity. Continuous measurement of unsteady flow velocity over the Riso airfoil with thick blunt trailing edge and base cavity is the most important innovation of this research...
2017: Journal of Visualization
https://www.readbyqxmd.com/read/29022157/radiosurgery-in-trochlear-and-abducens-nerve-schwannomas-case-series-and-systematic-review
#14
Iulia Peciu-Florianu, Constantin Tuleasca, Jean-Nicolas Comps, Luis Schiappacasse, Michele Zeverino, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Schwannomas involving the occulomotor cranial nerves  (CNs; III, IV and VI), can be disabling, due to the associated diplopia and decreased quality of life and are extremely rare. We evaluated the role of Gamma Knife surgery (GKS) in these cases. METHODS: Five patients with CN IV and VI schwannomas (three and two, respectively) were treated in Lausanne University Hospital between 2010 and 2015. Four benefitted from upfront GKS and one from a combined approach (planned subtotal resection followed by GKS), due to a large preoperative tumour volume (size, 3 × 2 × 2...
October 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28954850/the-power-speed-relationship-is-u-shaped-in-two-free-flying-hawkmoths-manducasexta
#15
Kajsa Warfvinge, Marco KleinHeerenbrink, Anders Hedenström
A flying animal can minimize its energy consumption by choosing an optimal flight speed depending on the task at hand. Choice of flight speed can be predicted by modelling the aerodynamic power required for flight, and this tool has previously been used extensively in bird migration research. For insects, however, it is uncertain whether any of the commonly used power models are useful, as insects often operate in a very different flow regime from vertebrates. To investigate this, we measured aerodynamic power in the wake of two Manduca sexta flying freely in a wind tunnel at 1-3...
September 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28945628/improvements-to-phakometry-using-bessel-beams
#16
Marwan Suheimat, Dipesh Bhattarai, Hannah K Maher, Meera Chandra, William Chelepy, Sarah K Halloran, Andrew J Lambert, David A Atchison
SIGNIFICANCE: The main problem with phakometry is the low visibility of the third Purkinje image. We built a phakometer using Bessel beams, which have properties of being resistant to diffraction and the potential for self-reconstruction. This instrument had lenticular images three times brighter than those of a conventional phakometer. PURPOSE: To investigate Purkinje image brightness, accuracy, and repeatability of a "Bessel" phakometer compared with those of a conventional phakometer...
November 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28913988/prevalence-of-respiratory-viral-infections-in-korean-adult-asthmatics-with-acute-exacerbations-comparison-with-those-with-stable-state
#17
Ki Hyun Seo, Da Jeong Bae, Ji Na Kim, Ho Sung Lee, Yong Hoon Kim, Jong Sook Park, Myung Shin Kim, Hun Soo Chang, Ji Hye Son, Dong Gyu Baek, Jun Suk Lee, Choon Sik Park
PURPOSE: Viral infections are involved in ~50% of exacerbations among Caucasian adult asthmatics. However, there have been few reports on the causative virus of exacerbations in Korean adult asthmatics. Thus, we compared frequencies and types of viruses between lower respiratory tract illnesses (LRTIs) with exacerbations (exacerbated LRTIs) and those without exacerbations (stable LRTIs) to evaluate contribution of respiratory viruses to exacerbations. METHODS: Viral RNA was extracted from sputum using the Viral Gene-spin™ Kit...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28910397/a-three-dimensional-strain-measurement-method-in-elastic-transparent-materials-using-tomographic-particle-image-velocimetry
#18
Azuma Takahashi, Sara Suzuki, Yusuke Aoyama, Mitsuo Umezu, Kiyotaka Iwasaki
BACKGROUND: The mechanical interaction between blood vessels and medical devices can induce strains in these vessels. Measuring and understanding these strains is necessary to identify the causes of vascular complications. This study develops a method to measure the three-dimensional (3D) distribution of strain using tomographic particle image velocimetry (Tomo-PIV) and compares the measurement accuracy with the gauge strain in tensile tests. METHODS AND FINDINGS: The test system for measuring 3D strain distribution consists of two cameras, a laser, a universal testing machine, an acrylic chamber with a glycerol water solution for adjusting the refractive index with the silicone, and dumbbell-shaped specimens mixed with fluorescent tracer particles...
2017: PloS One
https://www.readbyqxmd.com/read/28890680/study-of-flow-behaviors-of-droplet-merging-and-splitting-in-microchannels-using-micro-piv-measurement
#19
Feng Shen, Yi Li, Zhaomiao Liu, XiuJun Li
Droplet merging and splitting are important droplet manipulations in droplet-based microfluidics. However, the fundamental flow behaviors of droplets were not systematically studied. Hence, we designed two different microstructures to achieve droplet merging and splitting respectively, and quantitatively compared different flow dynamics in different microstructures for droplet merging and splitting via micro-particle image velocimetry (micro-PIV) experiments. Some flow phenomena of droplets different from previous studies were observed during merging and splitting using a high-speed microscope...
April 2017: Microfluidics and Nanofluidics
https://www.readbyqxmd.com/read/28868996/comparison-of-the-luminex-nxtag-respiratory-pathogen-panel-and-a-multiplex-in-house-real-time-pcr-panel-for-the-detection-of-respiratory-viruses-in-symptomatic-patients
#20
Andrew David Sails, Gary Eltringham, Manoj Valappil, Sheila Waugh, David Saunders
PURPOSE: To evaluate the Luminex NxTAG respiratory pathogen panel (NxTAG RPP) for the detection of respiratory viruses in clinical samples from patients with the symptoms of respiratory infection. METHODOLOGY: The NxTAG RPP was compared to an in-house multiplex real-time PCR panel (LDT) for the detection of respiratory viruses in 314 clinical samples from patients with the symptoms of respiratory infection. RESULTS: Thirty-one samples were negative in both tests and 193 samples contained a single virus that was detected in both tests...
September 4, 2017: Journal of Medical Microbiology
keyword
keyword
71217
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"