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https://www.readbyqxmd.com/read/29242062/rationale-and-design-of-the-sail-trial-for-intramuscular-injection-of-allogeneic-mesenchymal-stromal-cells-in-no-option-critical-limb-ischemia
#1
Joep G J Wijnand, Martin Teraa, Hendrik Gremmels, Femke C C van Rhijn-Brouwer, Gert J de Borst, Marianne C Verhaar
BACKGROUND: Critical limb ischemia (CLI) represents the most severe form of peripheral artery disease and has an immense impact on quality of life, morbidity, and mortality. A considerable proportion of CLI patients are ineligible for revascularization, leaving amputation as the only option. Mesenchymal stromal cells (MSCs), because of their vasculoregenerative and immunomodulatory characteristics, have emerged as a potential new treatment. METHODS: The primary objective of this trial is to investigate whether intramuscular administration of allogeneic bone marrow (BM)-derived MSCs is safe and potentially effective...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29239030/neuromuscular-training-reduces-lower-limb-injuries-in-elite-female-basketball-players-a-cluster-randomized-controlled-trial
#2
Matteo Bonato, Roberto Benis, Antonio La Torre
The study was a two-armed, parallel group, cluster randomized controlled trial in which 15 teams (160 players) were assigned to either an experimental group (EG, 8 teams n=86), which warmed-up with bodyweight neuromuscular exercises, or a control group (CG, 7 teams, n=74) that performed standard tactical-technical exercises before training. All injuries during the 2015-2016 regular season were counted. Epidemiologic incidence proportion and incidence rate, were also calculated. Counter movement jump (CMJ) and composite Y-Excursion balance test (YBT) were used to assess lower limb strength, and postural control...
December 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29231241/population-based-incidence-and-melanoma-specific-survival-of-cutaneous-malignant-melanoma-in-a-colombian-population-2000-2009
#3
Evy Reyes, Claudia Uribe, Esther de Vries
BACKGROUND: Demographic, clinical, and morphological characteristics of cutaneous melanoma are unknown for the Colombian population. We aim to provide these characteristics as well as population-based incidence and survival data. METHODS: All patients with an invasive cutaneous melanoma diagnosed in the period 2000-2009 registered in the population-based cancer registry of the metropolitan area of Bucaramanga were included for analysis (n = 169). Age-standardized incidence rates were calculated and melanoma-specific and overall survival estimated with follow-up until June 9, 2016, using Kaplan-Meier methodology, stratifying for gender, anatomical localization, and type of affiliation to the social security system...
December 12, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29225897/-bottom-hung-window-trauma-in-cats-neurological-evaluation-and-outcome-in-71-cats-with-bilateral-hindlimb-injury
#4
Gabriele M Gradner, Lina Dogman-Rauberger, Gilles Dupré
Objectives: Influence of neurological status on the mortality rate of paraparetic/paralysed cats presenting after entrapment in a bottom-hung window was evaluated. It was hypothesised that (1) loss of deep pain sensation at admission would not be a negative prognostic factor for regaining motor function and that (2) mortality rate would be influenced by the severity of neurological grade upon admission. Methods: Clinical and pathological data of affected cats that presented at our institution between 2001 and 2012 for this specific trauma were collected retrospectively: breed, age, sex, last contact with owner (<3 hours and >3 hours), whether the cat was suffering from monoparesis or paraparesis/paraplegia, duration of hospitalisation, rectal temperature, surface temperature of the skin of the hindlimbs, femoral pulse and tone of the pelvic musculature...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29224944/use-of-the-wound-ischemia-foot-infection-classification-system-in-hemodialysis-patients-after-endovascular-treatment-for-critical-limb-ischemia
#5
Takahiro Tokuda, Keisuke Hirano, Yasunari Sakamoto, Shisuke Mori, Norihiro Kobayashi, Motoharu Araki, Masahiro Yamawaki, Yoshiaki Ito
OBJECTIVE: The Wound, Ischemia, foot Infection (WIfI) classification system is used to predict the amputation risk in patients with critical limb ischemia (CLI). The validity of the WIfI classification system for hemodialysis (HD) patients with CLI is still unknown. This single-center study evaluated the prognostic value of WIfI stages in HD patients with CLI who had been treated with endovascular therapy (EVT). METHODS: A retrospective analysis was performed of collected data on CLI patients treated with EVT between April 2007 and December 2015...
December 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29214122/peripheral-nerve-sheath-tumors-of-the-upper-extremity-and-hand-in-patients-with-neurofibromatosis-type-1-topography-of-tumors-and-evaluation-of-surgical-treatment-in-62-patients
#6
Reinhard E Friedrich, Caroline Diekmeier
Objective: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome with a tendency to develop peripheral nerve sheath tumors (PNST). Plexiform neurofibromas (PNF) are detected in a high proportion of affected patients. The tumors can lead to severe disfigurement and are classified as precancerous. This study examines the surgical procedures that have been performed on large PNST of the upper limb and hand, and investigates whether a specific distribution pattern of the tumors can be detected in surgically treated cases...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/29209662/prehistoric-women-s-manual-labor-exceeded-that-of-athletes-through-the-first-5500-years-of-farming-in-central-europe
#7
Alison A Macintosh, Ron Pinhasi, Jay T Stock
The intensification of agriculture is often associated with declining mobility and bone strength through time, although women often exhibit less pronounced trends than men. For example, previous studies of prehistoric Central European agriculturalists (~5300 calibrated years BC to 850 AD) demonstrated a significant reduction in tibial rigidity among men, whereas women were characterized by low tibial rigidity, little temporal change, and high variability. Because of the potential for sex-specific skeletal responses to mechanical loading and a lack of modern comparative data, women's activity in prehistory remains difficult to interpret...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29209506/border-terriers-under-primary-veterinary-care-in-england-demography-and-disorders
#8
Dan G O'Neill, Elisabeth C Darwent, David B Church, Dave C Brodbelt
Background: The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using de-identified electronic patient record data within the VetCompass™ Programme. Results: Annual birth proportion for Border Terriers showed a decreasing trend from 1.46% in 2005 to 0.78% in 2014. The median adult bodyweight for males (10...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/29208323/evaluation-of-posterior-cruciate-ligament-and-intercondylar-notch-in-subjects-with-anterior-cruciate-ligament-tear-a-comparative-flexed-knee-3d-magnetic-resonance-imaging-study
#9
Atul K Taneja, Frederico C Miranda, Marco K Demange, Marcelo P Prado, Durval C B Santos, Laercio A Rosemberg, Ronaldo H Baroni
PURPOSE: To determine if posterior cruciate ligament (PCL) and intercondylar notch (IN) morphometries and volumetrics act as risk factors for anterior cruciate ligament (ACL) tears. METHODS: A prospective case-controlled magnetic resonance imaging (MRI) study was conducted with subjects presenting noncontact knee injuries. Exclusion criteria were previous surgery, PCL tear, osteoarthritis, tumors, or infectious and inflammatory conditions. All participants underwent a flexed-knee 3-dimensional (3D) magnetic resonance imaging (MRI) to uniformly straighten PCL...
December 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29202988/mobile-phone-generated-vibrations-used-to-detect-diabetic-peripheral-neuropathy
#10
Jonathan David May, Matthew William John Morris
BACKGROUND: In the current United Kingdom population the incidence of diabetic peripheral neuropathy is increasing. The presence of diabetic neuropathy affects decision making and treatment options. This study seeks to evaluate if the vibrations generated from a mobile phone can be used to screen patients for diabetic peripheral neuropathy. METHODS: This study comprised of 61 patients; a control group of 21 patients; a lower limb injury group of 19 patients; a diabetic peripheral neuropathy group of 21 patients...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29200424/arm-rehabilitation-in-post-stroke-subjects-a-randomized-controlled-trial-on-the-efficacy-of-myoelectrically-driven-fes-applied-in-a-task-oriented-approach
#11
Johanna Jonsdottir, Rune Thorsen, Irene Aprile, Silvia Galeri, Giovanna Spannocchi, Ettore Beghi, Elisa Bianchi, Angelo Montesano, Maurizio Ferrarin
PURPOSE: Motor recovery of persons after stroke may be enhanced by a novel approach where residual muscle activity is facilitated by patient-controlled electrical muscle activation. Myoelectric activity from hemiparetic muscles is then used for continuous control of functional electrical stimulation (MeCFES) of same or synergic muscles to promote restoration of movements during task-oriented therapy (TOT). Use of MeCFES during TOT may help to obtain a larger functional and neurological recovery than otherwise possible...
2017: PloS One
https://www.readbyqxmd.com/read/29191577/electrical-stimulation-of-the-insular-cortex-as-a-novel-target-for-the-relief-of-refractory-pain-an-experimental-approach-in-rodents
#12
Luiz Fabio Dimov, Elaine Flamia Toniolo, Heloísa Alonso-Matielo, Daniel Ciampi de Andrade, Luis Garcia-Larrea, Gerson Ballester, Manoel Jacobsen Teixeira, Camila Squarzoni Dale
Cortical electrical stimulation (CES) has shown to be an effective therapeutic alternative for neuropathic pain refractory to pharmacological treatment. The primary motor cortex(M1) was the main cortical target used in the vast majority of both invasive and non-invasive studies. Despite positive results M1-based approaches still fail to relieve pain in a significant proportion of individuals. It has been advocated that the direct stimulation of cortical areas directly implicated in the central integration of pain could increase the efficacy of analgesic brain stimulation...
November 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29178940/restoration-of-motor-control-and-proprioceptive-and-cutaneous-sensation-in-humans-with-prior-upper-limb-amputation-via-multiple-utah-slanted-electrode-arrays-useas-implanted-in-residual-peripheral-arm-nerves
#13
Suzanne Wendelken, David M Page, Tyler Davis, Heather A C Wark, David T Kluger, Christopher Duncan, David J Warren, Douglas T Hutchinson, Gregory A Clark
BACKGROUND: Despite advances in sophisticated robotic hands, intuitive control of and sensory feedback from these prostheses has been limited to only 3-degrees-of-freedom (DOF) with 2 sensory percepts in closed-loop control. A Utah Slanted Electrode Array (USEA) has been used in the past to provide up to 81 sensory percepts for human amputees. Here, we report on the advanced capabilities of multiple USEAs implanted in the residual peripheral arm nerves of human amputees for restoring control of 5 DOF and sensation of up to 131 proprioceptive and cutaneous hand sensory percepts...
November 25, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29170258/mechanisms-for-the-functional-differentiation-of-the-propulsive-and-braking-roles-of-the-forelimbs-and-hindlimbs-during-quadrupedal-walking-in-primates-and-felines
#14
Michael C Granatosky, Aidan Fitzsimons, Angel Zeininger, Daniel Schmitt
During quadrupedal walking in most animals, the forelimbs play a net braking role while the hindlimbs are net propulsive. However, the mechanism by which this differentiation occurs remains unclear. Here we test two models to explain this pattern using primates and felines: (1) the Horizontal Strut Effect (in which limbs are modeled as independent struts), and (2) the Linked Strut Model (in which limbs are modeled as linked struts with a center of mass in between). Video-recordings were used to determine point of contact, mid-stance, and limb protraction/retraction duration...
November 23, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29168277/congenital-limb-deficiencies-and-major-associated-anomalies-in-alberta-for-the-years-1980-2012
#15
Tanya Bedard, R Brian Lowry, Barbara Sibbald, Susan Crawford, Gerhard N Kiefer
There is a wide range of the proportion of congenital anomalies associated with limb deficiencies reported in the literature. This variation is primarily attributed to methodology and classification differences. The distribution of associated anomalies among cases with congenital limb deficiencies in Alberta born between January 1, 1980 and December 31, 2012 is described. Of the 170 cases identified, most were live born (75.3%), male (61.8%), had longitudinal limb deficiencies (78.8%), and had associated anomalies outside the musculoskeletal system (77...
November 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29157680/immediate-and-late-outcomes-of-endovascular-therapy-for-lower-extremity-arteries-in-buerger-disease
#16
Dae-Hoon Kim, Young-Guk Ko, Chul-Min Ahn, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
OBJECTIVE: Buerger disease is a rare inflammatory vasculopathy presenting with severe claudication or critical limb ischemia. In this study, we sought to evaluate the feasibility and clinical outcomes of endovascular therapy for Buerger disease involving arteries in the lower extremities. METHODS: Between January 2006 and May 2016, there were 44 Buerger disease patients (43 men; mean age, 40.4 ± 9.6 years) with 50 target limbs treated by endovascular therapy at the Severance Cardiovascular Hospital...
November 17, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29153498/hemodynamic-assessment-before-and%C3%A2-after-endovascular-therapy-for-critical%C3%A2-limb-ischemia-and-association-with-clinical-outcomes
#17
Grant W Reed, Laura Young, Imad Bagh, Michael Maier, Mehdi H Shishehbor
OBJECTIVES: This study sought to determine the relationship between change in ankle-brachial index (ABI) and toe-brachial index (TBI) and outcomes following revascularization of critical limb ischemia (CLI). BACKGROUND: An increase in ABI of 0.15 after revascularization for peripheral artery disease with claudication is considered significant. However, the utility of using change in ABI or TBI to predict outcomes in patients with CLI is unproven. METHODS: This was an observational study of 218 patients with Rutherford class V or VI CLI that underwent endovascular therapy...
November 7, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29153109/non-invasive-blood-pressure-measurement-in-ferrets-mustela-putorius-furo-using-high-definition-oscillometry
#18
Y R A van Zeeland, A Wilde, I H Bosman, J J Uilenreef, B Egner, N J Schoemaker
This study was conducted to validate the use of high definition oscillometry (HDO) for non-invasive blood pressure (NIBP) measurements in ferrets and to establish reference ranges for NIBP in minimally sedated, healthy, young adult ferrets (<4years of age). The bias, limits of agreement and correlation for HDO compared to direct arterial blood pressure (DABP) measurement were established in 14 anaesthetised ferrets. Measurements were performed at the forelimb, hind limb and tail under hypo- (<110mmHg), normo- (110-170mmHg) and hypertensive (>170mmHg) conditions...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29152190/sex-and-weaponry-the-distribution-of-toxin-storage-glands-on-the-bodies-of-male-and-female-cane-toads-rhinella-marina
#19
Wei Chen, Cameron M Hudson, Jayna L DeVore, Richard Shine
The parotoid macroglands of bufonid anurans store (and can expel) large volumes of toxic secretions and have attracted detailed research. However, toxins also are stored in smaller glands that are distributed on the limbs and dorsal surface of the body. Female and male cane toads (Rhinella marina) differ in the location of toxin-storage glands and the extent of glandular structures. Female toads store a larger proportion of their toxins in the parotoids than males as well as (to a lesser extent) in smaller glands on the forelimbs...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#20
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
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