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https://www.readbyqxmd.com/read/29663403/smoke-induced-neuromuscular-junction-degeneration-precedes-the-fibre-type-shift-and-atrophy-in-copd
#1
Sophia Kapchinsky, Madhusudanarao Vuda, Kayla Miguez, Daren Elkrief, Angela R de Souza, Carolyn J Baglole, Sudhakar Aare, Norah J MacMillan, Jacinthe Baril, Paul Rozakis, Vita Sonjak, Charlotte Pion, Mylène Aubertin-Leheudre, Jose A Morais, R Thomas Jagoe, Jean Bourbeau, Tanja Taivassalo, Russell T Hepple
A neurological basis for the fast fibre shift and atrophy seen in limb muscle of patients with chronic obstructive pulmonary disease (COPD) has not been considered previously. The objective of our study was: (i) to determine if denervation contributes to fast fibre shift and muscle atrophy in COPD; and (ii) to assess using a preclinical smoking mouse model whether chronic tobacco smoke (TS) exposure could initiate denervation by causing neuromuscular junction (NMJ) degeneration. Vastus lateralis muscle biopsies were obtained from severe COPD patients (n = 10 with low fat free mass index [FFMI], 65 y; n = 15 normal FFMI, 65 y) and healthy age- and activity-matched non-smoker control subjects (CON; n = 11, 67 y), to evaluate morphological and transcriptional markers of denervation...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29657781/comparative-limb-proportions-reveal-differential-locomotor-morphofunctions-of-alligatoroids-and-crocodyloids
#2
Masaya Iijima, Tai Kubo, Yoshitsugu Kobayashi
Although two major clades of crocodylians (Alligatoroidea and Crocodyloidea) were split during the Cretaceous period, relatively few morphological and functional differences between them have been known. In addition, interaction of multiple morphofunctional systems that differentiated their ecology has barely been assessed. In this study, we examined the limb proportions of crocodylians to infer the differences of locomotor functions between alligatoroids and crocodyloids, and tested the correlation of locomotor and feeding morphofunctions...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29655806/is-there-a-role-for-intervention-radiology-for-the-treatment-of-lower-limb-deep-vein-thrombosis-in-the-era-of-direct-oral-anticoagulants-a-comprehensive-review
#3
REVIEW
Marco Marietta, Elisa Romagnoli, Benilde Cosmi, Valeria Coluccio, Mario Luppi
Despite recent advances in the treatment of Deep Vein Thrombosis (DVT) provided by Direct Oral Anticoagulants (DOAC), a substantial proportion of lower limb DVT patients will develop some degree of post-thrombotic syndrome (PTS) within 2 years. Systemic thrombolysis, although effective in reducing the risk of PTS and leg ulceration, is associated with a high risk of major bleeding, making it unsuitable for the vast majority of patients. A local approach, aimed at delivering the fibrinolytic drug directly into, or near to, the thrombus surface, is attractive because of the possibility of lowering of the administered drug dose, thus reducing the bleeding risks...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29649055/the-impact-of-once-versus-twice-daily-enoxaparin-prophylaxis-on-risk-for-venous-thromboembolism-and-clinically-relevant-bleeding
#4
Christopher J Pannucci, Kory I Fleming, Jayant Agarwal, W Bradford Rockwell, Ann Marie Prazak, Arash Momeni
INTRODUCTION: Venous thromboembolism (VTE) is a life or limb threatening complication that occurs in plastic surgery patients. At present, the optimal dose of enoxaparin that balances the risk of VTE and the risk of medication related adverse drug events, specifically bleeding, remains unknown. METHODS: This study compared pharmacodynamic and clinical outcomes, including 90-day VTE and 90-day clinically relevant bleeding, between two prospectively performed clinical trials whose sole difference was post-operative anticoagulation strategy...
March 30, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29624722/volumetric-bone-mineral-density-and-failure-load-of-distal-limbs-predict-incident-clinical-fracture-independent-of-frax-and-clinical-risk-factors-among-older-men
#5
Lisa Langsetmo, Katherine W Peters, Andrew J Burghardt, Kristine E Ensrud, Howard A Fink, Peggy M Cawthon, Jane A Cauley, John T Schousboe, Elizabeth Barrett-Connor, Eric S Orwoll
Our objective was to determine the associations of peripheral bone strength and microarchitecture with incident clinical and major osteoporotic fracture among older men after adjusting for major clinical risk factors. We used a prospective cohort study design with data from 1794 men (mean age 84.4 years) in the Osteoporotic Fractures in Men (MrOS) study. Eligible men attended the Year 14 visit, had high resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia, DXA measured BMD, and were followed for mean 1...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29622543/postoperative-death-after-lower-limb-amputation-in-a-national-prevalent-cohort-of-patients-with-diabetes
#6
Jason K Gurney, James Stanley, Juliet Rumball-Smith, Steve York, Diana Sarfati
OBJECTIVE: The objectives of this study were to 1 ) describe postoperative mortality after lower-limb amputation in a national prevalent cohort of patients with diabetes, and 2 ) investigate whether postoperative mortality differs by demographic subgroup, patient morbidity level, and health system factors related to the facility in which the amputation occurred. RESEARCH DESIGN AND METHODS: A national prevalent cohort of 302,339 individuals diagnosed with diabetes between 2005 and 2014 were followed until the end of 2014 for major and minor lower-limb amputation and subsequent postoperative mortality by using national health data collections...
April 5, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29619928/studies-of-upper-limb-pain-in-occupational-medicine-in-general-practice-and-among-computer-operators
#7
Jørgen Riis Jepsen
Diagnostic consensus criteria cannot be applied in a major proportion of patients with upper limb complaints, many of which are regarded as "non-specific". The three empirical studies in this thesis aimed to address this diagnostic challenge by incorporating representative neurological qualities in the physical examination.
Patterns of muscle weakness, sensory abnormalities and nerve trunk allodynia based on the nerves' topography and their motor and cutaneous innervation were defined to reflect peripheral nerve afflictions and their locations...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29607020/patterns-of-musculoskeletal-growth-and-dimensional-changes-associated-with-selection-and-developmental-plasticity-in-domestic-and-wild-strain-turkeys
#8
Kristin K Stover, Daniel M Weinreich, Thomas J Roberts, Elizabeth L Brainerd
Domestication is a type of experimental evolution in which humans have artificially selected for specific desired traits. Selected strain animals can be utilized to identify correlated responses by comparing them to the wild strain. In particular, domestic turkeys have been selected for increased body mass and high-growth rate, most significantly over the past 60 years. Yet it remains unclear how artificial selection has affected the morphology and evolution of the musculoskeletal system as a whole. Here, we compare growth rate over 21 weeks, hind limb bone scaling across ontogeny via in vivo CT scanning, and muscle proportions in wild and domestic turkeys to identify differences in structural scaling and the potential contributions of selection and developmental plasticity to whole-organism morphology...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29605522/trial-protocol-home-based-exercise-programs-to-prevent-falls-and-upper-limb-dysfunction-among-community-dwelling-older-people-study-protocol-for-the-best-balance-exercise-strength-training-at-home-randomised-controlled-trial
#9
Amanda Bates, Susan Furber, Anne Tiedemann, Karen Ginn, Paul van den Dolder, Kirsten Howard, Adrian Bauman, Cathy Chittenden, Lisa Franco, Michelle Kershaw, Catherine Sherrington
INTRODUCTION: Falling when older is a major public health issue. There is compelling evidence to show that specific exercise programs can reduce the risk and rate of falls in community-dwelling older people. Another major health issue for older people living in the community is upper limb dysfunction, including shoulder pain. Home-based exercise programs appeal to some older people, due to their convenience. RESEARCH QUESTIONS: This trial aims to determine the effectiveness and cost-effectiveness of a home-based lower limb exercise program compared with a home-based upper limb exercise program to prevent falls and upper limb dysfunction among community-dwelling people aged 65+ years...
March 28, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29604401/limb-muscle-quality-and-quantity-in-elderly-adults-with-dynapenia-but-not-sarcopenia-an-ultrasound-imaging-study
#10
Ke-Vin Chang, Wei-Ting Wu, Kuo-Chin Huang, Wei Han Jan, Der-Sheng Han
BACKGROUND: Dynapenia is prevalent in people with reduced skeletal muscle mass, i.e. sarcopenia, but a certain population develops muscle strength loss despite having normal skeletal muscle volume. To date, studies investigating muscle quality and quantity in groups with dynapenia but not sarcopenia are limited. METHODS: Echogenicity and thickness of the biceps brachii, triceps brachii, rectus femoris, and medial gastrocnemius muscles were measured using high-resolution ultrasonography in 140 community-dwelling elderly adults...
March 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29602552/screening-practices-and-associated-anomalies-in-infants-with-anorectal-malformations-results-from-the-midwest-pediatric-surgery-consortium
#11
Peter C Minneci, Rashmi S Kabre, Grace Z Mak, Devin R Halleran, Jennifer N Cooper, Amin Afrazi, Casey M Calkins, Cynthia D Downard, Peter Ehrlich, Jason Fraser, Samir K Gadepalli, Michael A Helmrath, Jonathan E Kohler, Rachel Landisch, Matthew P Landman, Constance Lee, Charles M Leys, Daniel L Lodwick, Rodrigo Mon, Beth McClure, Beth Rymeski, Jacqueline M Saito, Thomas T Sato, Shawn D St Peter, Richard Wood, Marc A Levitt, Katherine J Deans
BACKGROUND: This study evaluates screening practices and the incidence of associated anomalies in infants with anorectal malformations (ARM). METHODS: We performed a multi-institutional retrospective cohort study of children born between 2007 and 2011 who underwent surgery for ARM at 10 children's hospitals. ARM type was classified based on the location of the distal rectum, and all screening studies were reviewed. RESULTS: Among 506 patients, the most common ARM subtypes were perineal fistula (40...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29590559/decreased-prefrontal-oxygenation-elicited-by-stimulation-of-limb-mechanosensitive-afferents-during-cycling-exercise
#12
Ryota Asahara, Kanji Matsukawa
Our laboratory reported using near-infrared spectroscopy that feedback from limb mechanoafferents may decrease prefrontal oxygenated-hemoglobin concentration (Oxy-Hb) during the late period of voluntary and passive cycling. To test the hypothesis that the decreased Oxy-Hb of the prefrontal cortex would be augmented depending on the extent of limb mechanoafferent input, the prefrontal Oxy-Hb response was measured during motor-driven one- and two-legged passive cycling for 1 min at various revolutions of pedal movement in 19 subjects...
March 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29589777/mirror-therapy-and-treadmill-training-for-a-patient-with-chronic-stroke-a-case-report
#13
Patrick Broderick, Frances Horgan, Catherine Blake, Paula Hickey, Joanne O'Reilly, Monika Ehrensberger, Daniel Simpson, David Roberts, Kenneth Monaghan
INTRODUCTION: A large proportion of patients with chronic stroke have permanent lower limb functional disability leading to reduced levels of independent mobility. Individually, both mirror therapy and treadmill training have been shown to improve aspects of lower limb functioning in patients with stroke. This case report examined whether a new combination of both interventions would lead to improvements in lower limb functional disability for a patient with chronic stroke. CASE DESCRIPTION: The participant was a 50-year-old female who had a left middle cerebral artery infarction (47 months' post stroke)...
March 28, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29589075/-operative-treatment-of-diabetics-with-vascular-complications-secondary-data-analysis-of-diagnosis-related-groups-statistics-from-2005-to-2014-in-germany
#14
M Olm, A Kühnl, E Knipfer, M Salvermoser, H-H Eckstein, A Zimmermann
BACKGROUND: In Germany approximately 40,000 amputations per year are performed on patients with diabetes mellitus, often with accompanying vascular complications. OBJECTIVE: The aim of this study was to present the various degrees of severity of the vascular complications and the temporal changes of the treatment options in diabetics with vascular complications in Germany. MATERIAL AND METHODS: The microdata of the diagnosis-related groups (DRG) statistics of the Federal Statistical Office were analyzed over the period from 2005 to 2014...
March 27, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29588132/epidemiology-of-lower-extremity-peripheral-artery-disease-in-veterans
#15
James Willey, Amgad Mentias, Mary Vaughan-Sarrazin, Kimberly McCoy, Gary Rosenthal, Saket Girotra
OBJECTIVE: The objective of this study was to describe the epidemiology, clinical features, outcomes, and predictors of mortality in veterans with peripheral artery disease (PAD). METHODS: We used national data from the Veterans Health Administration from fiscal years 2009 to 2011 to identify patients with a new diagnosis of PAD. Within this cohort, we describe characteristics of the patients, use of recommended medications, and clinical outcomes during a 3-year follow-up (fiscal year 2014)...
March 24, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29587833/use-of-hybrid-assistive-limb-hal-%C3%A2-for-a-postoperative-patient-with-cerebral-palsy-a-case-report
#16
Yuki Mataki, Hiroshi Kamada, Hirotaka Mutsuzaki, Yukiyo Shimizu, Ryoko Takeuchi, Masafumi Mizukami, Kenichi Yoshikawa, Kazushi Takahashi, Mayumi Matsuda, Nobuaki Iwasaki, Hiroaki Kawamoto, Yasuyoshi Wadano, Yoshiyuki Sankai, Masashi Yamazaki
BACKGROUND: The Hybrid Assistive Limb (HAL® ) is an exoskeleton wearable robot suit that assists in voluntary control of knee and hip joint motion. There have been several studies on HAL intervention effects in stroke, spinal cord injury, and cerebral palsy. However, no study has investigated HAL intervention for patients with cerebral palsy after surgery. CASE PRESENTATION: We report a case of using HAL in a postoperative patient with cerebral palsy. A 15-year-old boy was diagnosed with spastic diplegia cerebral palsy Gross Motor Function Classification System level IV, with knee flection contracture, equinus foot, and paralysis of the right upper extremity with adduction contracture...
March 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29579308/the-effect-of-albendazole-treatment-on-non-seizure-outcomes-in-patients-with-symptomatic-neurocysticercosis
#17
Kriti Thapa, Matthew L Romo, Arturo Carpio, Denise Leslie, Howard Andrews, W Allen Hauser, Elizabeth A Kelvin
Background: There is little information about the impact of anthelminthic treatment on clinical symptoms other than seizures in neurocysticercosis (NC). We investigated the effect of albendazole on non-seizure symptoms experienced by patients with NC. Methods: Data are from a randomized controlled trial comparing albendazole plus prednisone with placebo plus prednisone for treatment of NC among 173 patients with active or transitional NC cysts and new-onset symptoms...
March 22, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29576595/therapeutic-efficacy-of-autologous-non-mobilized-enriched-circulating-endothelial-progenitors-in-patients-with-critical-limb-ischemia-the-scelta-trial
#18
Francesco Liotta, Francesco Annunziato, Sergio Castellani, Maria Boddi, Brunetto Alterini, Giovanni Castellini, Benedetta Mazzanti, Lorenzo Cosmi, Manlio Acquafresca, Filippo Bartalesi, Beatrice Dilaghi, Walter Dorigo, Gabriele Graziani, Benedetta Bartolozzi, Guido Bellandi, Giulia Carli, Alessandro Bartoloni, Aaron Fargion, Filippo Fassio, Paolo Fontanari, Giancarlo Landini, Eleonora A M Lucente, Stefano Michelagnoli, Carolina Orsi Battaglini, Grazia Panigada, Clara Pigozzi, Valentina Querci, Veronica Santarlasci, Paola Parronchi, Nicola Troisi, Cristiana Baggiore, Paola Romagnani, Edoardo Mannucci, Riccardo Saccardi, Carlo Pratesi, Gianfranco Gensini, Sergio Romagnani, Enrico Maggi
BACKGROUND: The therapeutic efficacy of bone marrow mononuclear cells (BM-MNC) autotransplantation in critical limb ischemia (CLI) has been reported. Variable proportions of circulating monocytes express low levels of CD34 (CD14+ CD34low cells) and behave in vitro as endothelial progenitor cells (EPCs). The aim of the present randomized clinical trial was to compare the safety and therapeutic effects of enriched circulating EPCs (ECEPCs) with BM-MNC administration.Methods and Results:ECEPCs (obtained from non-mobilized peripheral blood by immunomagnetic selection of CD14+ and CD34+ cells) or BM-MNC were injected into the gastrocnemius of the affected limb in 23 and 17 patients, respectively...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29555530/negative-pressure-wound-therapy-versus-conventional-wound-dressings-in-treatment-of-open-fractures-a-systematic-review-and-meta-analysis
#19
REVIEW
Xi Liu, Hui Zhang, Shiqiang Cen, Fuguo Huang
BACKGROUND: Though several systematic reviews concerned have been published, controversy still exists. The current systematic review was designed to clarify the detailed advantages and disadvantages of the negative pressure wound therapy (NPWT) in treatment of open fractures in comparison with the conventional wound dressings. METHODS: A systematic search was performed in Pubmed, Cochrane Library, Embase, and Google Scholar for the published relevant clinical studies...
March 16, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29555149/the-incidence-prevalence-severity-mechanism-and-body-region-of-injury-in-elite-junior-australian-football-players-a-prospective-cohort-study-over-one-season
#20
Timothy J H Lathlean, Paul B Gastin, Stuart V Newstead, Caroline F Finch
OBJECTIVES: To describe the incidence, prevalence, severity, mechanism and body region of injuries in elite junior Australian football (AF) players over one competitive season in order to help inform injury prevention interventions. DESIGN: Prospective cohort, data collected during the 2014 playing season. METHODS: Player and staff-reported injuries sustained by 562 players from an under-18 state league were entered into an online sports injury surveillance system...
March 14, 2018: Journal of Science and Medicine in Sport
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