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https://www.readbyqxmd.com/read/28523540/rubinstein-taybi-syndrome-and-epigenetic-alterations
#1
Edward Korzus
Rubinstein-Taybi syndrome (RSTS) is a rare genetic disorder in humans characterized by growth and psychomotor delay, abnormal gross anatomy, and mild to severe mental retardation (Rubinstein and Taybi, Am J Dis Child 105:588-608, 1963, Hennekam et al., Am J Med Genet Suppl 6:56-64, 1990). RSTS is caused by de novo mutations in epigenetics-associated genes, including the cAMP response element-binding protein (CREBBP), the gene-encoding protein referred to as CBP, and the EP300 gene, which encodes the p300 protein, a CBP homologue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28518097/light-sheet-based-fluorescence-microscopy-of-living-or-fixed-and-stained-tribolium-castaneum-embryos
#2
Frederic Strobl, Selina Klees, Ernst H K Stelzer
The red flour beetle Tribolium castaneum has become an important insect model organism in developmental genetics and evolutionary developmental biology. The observation of Tribolium embryos with light sheet-based fluorescence microscopy has multiple advantages over conventional widefield and confocal fluorescence microscopy. Due to the unique properties of a light sheet-based microscope, three dimensional images of living specimens can be recorded with high signal-to-noise ratios and significantly reduced photo-bleaching as well as photo-toxicity along multiple directions over periods that last several days...
April 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28514427/illuminating-developmental-biology-through-photochemistry
#3
Lukasz Kowalik, James K Chen
Developmental biology has been continually shaped by technological advances, evolving from a descriptive science into one immersed in molecular and cellular mechanisms. Most recently, genome sequencing and 'omics' profiling have provided developmental biologists with a wealth of genetic and biochemical information; however, fully translating this knowledge into functional understanding will require new experimental capabilities. Photoactivatable probes have emerged as particularly valuable tools for investigating developmental mechanisms, as they can enable rapid, specific manipulations of DNA, RNA, proteins, and cells with spatiotemporal precision...
May 17, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28508696/a-bibliometric-analysis-of-occupational-therapy-publications
#4
Ted Brown, Sharon A Gutman, Yuh-Shan Ho, Kenneth N K Fong
BACKGROUND: Bibliometrics involves the statistical analysis of the publications in a specific discipline or subject area. A bibliometric analysis of the occupational therapy refereed literature is needed. AIM: A bibliometric analysis was completed of the occupational therapy literature from 1991-2014, indexed in the Science Citation Index-Expanded or the Social Sciences Citation Index. METHOD: Publications were searched by title, abstract, keywords, and KeyWords Plus...
May 16, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28508672/assessing-infant-oriented-care-with-developmental-support-approach-in-iranian-nicus
#5
Mostajab Razavi Nejad, Zahra Eskandary, Mohammad Heidarzadeh, Abolfazl Afjeh, Amir Almasi-Hashiani, Forouzan Akrami
INTRODUCTION: Developmental care program is a comprehensive program to reduce secondary effects of NICU and special care on brain development in premature infants. This study aimed to assess neonatal care situation in Iranian NICUs based on developmental approach to design and provide clinical guidelines for daily care for the care givers and the infant's family. METHODS: This was a cross-sectional study conducted in NICUS in Iran. A total of 23 NICUs of 9 Universities of Medical Sciences were investigated...
May 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28503769/identification-of-factors-required-for-m-6-a-mrna-methylation-in-arabidopsis-reveals-a-role-for-the-conserved-e3-ubiquitin-ligase-hakai
#6
Kamil Růžička, Mi Zhang, Ana Campilho, Zsuzsanna Bodi, Muhammad Kashif, Mária Saleh, Dominique Eeckhout, Sedeer El-Showk, Hongying Li, Silin Zhong, Geert De Jaeger, Nigel P Mongan, Jan Hejátko, Ykä Helariutta, Rupert G Fray
N6-adenosine methylation (m(6) A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemistry, we identified a core set of mRNA m(6) A writer proteins in Arabidopsis thaliana. The components required for m(6) A in Arabidopsis included MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI. Downregulation of these proteins led to reduced relative m(6) A levels and shared pleiotropic phenotypes, which included aberrant vascular formation in the root, indicating that correct m(6) A methylation plays a role in developmental decisions during pattern formation...
May 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/28493364/explicating-the-role-of-empathic-processes-in-substance-use-disorders-a-conceptual-framework-and-research-agenda
#7
Suena H Massey, Rebecca L Newmark, Lauren S Wakschlag
ISSUES: Elucidating the role of empathic processes in developmental pathways to substance use disorders could have important implications for prevention. APPROACH: We searched the biomedical and social sciences literature to determine what is known about empathy and psychopathological manifestations of severe lack of empathy in the initiation, development and maintenance of psychoactive substance use. Thirty-seven empirical studies were identified and formally reviewed...
May 10, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28488810/one-gene-multiple-alleles-insights-into-the-microevolution-of-pigmentation-polymorphisms
#8
M Emília Santos
Understanding how phenotypic variation is generated and maintained, and the evolutionary forces that shape these processes is the main goal of evolutionary biology. Great progress has been made in uncovering the genetic basis of morphological diversity, yet little is known about both the genetics and developmental basis of discrete polymorphisms segregating in wild populations. Exploring variation in developmental mechanisms at the population level can address the long-standing question of whether the mechanisms of change are the same at the micro- and macroevolutionary scale...
May 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28486128/a-geometric-model-of-stripe-refinement
#9
Eric D Siggia
Organizing data about patterning and morphogenesis into a coherent framework remains a challenge in developmental biology. Reporting in Science, Corson et al. (2017) apply innovative analysis to an old problem of bristle patterns in Drosophila, reducing the nonlinear interactions among tens of cells to a succinct model with quantitative predictions.
May 8, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28482854/medical-decision-making-in-children-and-adolescents-developmental-and-neuroscientific-aspects
#10
REVIEW
Petronella Grootens-Wiegers, Irma M Hein, Jos M van den Broek, Martine C de Vries
BACKGROUND: Various international laws and guidelines stress the importance of respecting the developing autonomy of children and involving minors in decision-making regarding treatment and research participation. However, no universal agreement exists as to at what age minors should be deemed decision-making competent. Minors of the same age may show different levels of maturity. In addition, patients deemed rational conversation-partners as a child can suddenly become noncompliant as an adolescent...
May 8, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28475257/v-design-based-approaches-for-improving-measurement-in-developmental-science
#11
Jonathan Rush, Scott M Hofer
The study of change and variation within individuals, and the relative comparison of changes across individuals, relies on the assumption that observed measurements reflect true change in the construct being measured. Measurement properties that change over time, contexts, or people pose a fundamental threat to validity and lead to ambiguous conclusions about change and variation. We highlight such measurement issues from a within-person perspective and discuss the merits of measurement-intensive research designs for improving precision of both within-person and between-person analysis...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28475256/i-developmental-methodology-as-a-central-subdiscipline-of-developmental-science
#12
Noel A Card
This first chapter introduces the main goals of the monograph and previews the remaining chapters. The goals of this monograph are to provide summaries of our current understanding of advanced developmental methodologies, provide information that can advance our understanding of human development, identify shortcomings in our understanding of developmental methodology, and serve as a flagpost for organizing developmental methodology as a subdiscipline within the broader field of developmental science. The remaining chapters in this monograph address issues in design (sampling and big data), longitudinal data analysis, and issues of replication and research accumulation...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28475255/observations-about-how-we-learn-about-methodology-and-statistics
#13
Paul E Jose
The overarching theme of this monograph is to encourage developmental researchers to acquire cutting-edge and innovative design and statistical methods so that we can improve the studies that we execute on the topic of change. Card, the editor of the monograph, challenges the reader to think about works such as the present one as contributing to the new subdiscipline of developmental methodology within the broader field of developmental science. This thought-provoking stance served as the stimulus for the present commentary, which is a collection of observations on "how we learn about methodology and statistics...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28475254/ii-more-than-just-convenient-the-scientific-merits-of-homogeneous-convenience-samples
#14
Justin Jager, Diane L Putnick, Marc H Bornstein
Despite their disadvantaged generalizability relative to probability samples, nonprobability convenience samples are the standard within developmental science, and likely will remain so because probability samples are cost-prohibitive and most available probability samples are ill-suited to examine developmental questions. In lieu of focusing on how to eliminate or sharply reduce reliance on convenience samples within developmental science, here we propose how to augment their advantages when it comes to understanding population effects as well as subpopulation differences...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28475252/iii-from-small-to-big-methods-for-incorporating-large-scale-data-into-developmental-science
#15
Pamela E Davis-Kean, Justin Jager
For decades, developmental science has been based primarily on relatively small-scale data collections with children and families. Part of the reason for the dominance of this type of data collection is the complexity of collecting cognitive and social data on infants and small children. These small data sets are limited in both power to detect differences and the demographic diversity to generalize clearly and broadly. Thus, in this chapter we will discuss the value of using existing large-scale data sets to tests the complex questions of child development and how to develop future large-scale data sets that are both representative and can answer the important questions of developmental scientists...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28475251/vii-replication-research-accumulation-and-meta-analysis-in-developmental-science
#16
Noel A Card
The progression of scientific knowledge requires replication of research results and an orderly accumulation of research knowledge. However, developmental science, like many other sciences, has too often prioritized individual studies at the expense of replication and synthesis efforts. In this chapter, I describe the concepts of replication and research accumulation and consider both their barriers and potentials for developmental science. I emphasize the importance of considering effect sizes rather than statistical significance, and I describe meta-analysis as a powerful tool in facilitating research accumulation and in guiding replication efforts...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28470439/accelerating-progress-a-new-era-of-research-on-character-development
#17
EDITORIAL
Sarah Clement, Richard Bollinger
Adolescent character development is a high priority for educators, policymakers, and front-line youth workers. To meet this growing demand, and as exemplified in the five articles in this special section, character development scholars are drawing from a range of academic disciplines to push beyond the traditional boundaries of the science of character development. These articles highlight important trends in character research, including the co-development of a subset of character strengths, the articulation of developmental trajectories of character, the use of advanced methodological approaches, and the implications for education...
May 3, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28458499/gender-gap-in-science-technology-engineering-and-mathematics-stem-current-knowledge-implications-for-practice-policy-and-future-directions
#18
Ming-Te Wang, Jessica L Degol
Although the gender gap in math course-taking and performance has narrowed in recent decades, females continue to be underrepresented in math-intensive fields of Science, Technology, Engineering, and Mathematics (STEM). Career pathways encompass the ability to pursue a career as well as the motivation to employ that ability. Individual differences in cognitive capacity and motivation are also influenced by broader sociocultural factors. After reviewing research from the fields of psychology, sociology, economics, and education over the past 30 years, we summarize six explanations for US women's underrepresentation in math-intensive STEM fields: (a) cognitive ability, (b) relative cognitive strengths, (c) occupational interests or preferences, (d) lifestyle values or work-family balance preferences, (e) field-specific ability beliefs, and (f) gender-related stereotypes and biases...
March 2017: Educational Psychology Review
https://www.readbyqxmd.com/read/28438675/integrating-cell-biology-and-proteomic-approaches-in-plants
#19
Tomáš Takáč, Olga Šamajová, Jozef Šamaj
Significant improvements of protein extraction, separation, mass spectrometry and bioinformatics nurtured advancements of proteomics during the past years. The usefulness of proteomics in the investigation of biological problems can be enhanced by integration with other experimental methods from cell biology, genetics, biochemistry, pharmacology, molecular biology and other omics approaches including transcriptomics and metabolomics. This review aims to summarize current trends integrating cell biology and proteomics in plant science...
April 21, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28435745/a-consult-service-to-support-and-promote-community-based-research-tracking-and-evaluating-a-community-based-research-consult-service
#20
Clara M Pelfrey, Katrice D Cain, Mary Ellen Lawless, Earl Pike, Ashwini R Sehgal
PURPOSE: This study describes the design, operation and evaluation of a community-based research (CBR) consult service within the setting of a Clinical and Translational Science Award (CTSA) institution. To our knowledge, there are no published evaluations of a CBR consult service at a CTSA hub. METHODS: A community-based research Consult Service was created to support faculty, health care providers/research coordinators, trainees, community-based organizations and community members...
February 2017: J Clin Transl Sci
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