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https://www.readbyqxmd.com/read/29908669/safety-and-efficacy-of-upadacitinib-in-patients-with-rheumatoid-arthritis-and-inadequate-response-to-conventional-synthetic-disease-modifying-anti-rheumatic-drugs-select-next-a-randomised-double-blind-placebo-controlled-phase-3-trial
#1
Gerd R Burmester, Joel M Kremer, Filip Van den Bosch, Alan Kivitz, Louis Bessette, Yihan Li, Yijie Zhou, Ahmed A Othman, Aileen L Pangan, Heidi S Camp
BACKGROUND: Upadacitinib is a selective inhibitor of Janus kinase 1 and was efficacious in phase 2 studies in patients with moderate-to-severe rheumatoid arthritis. We aimed to assess the efficacy of upadacitinib in patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). METHODS: This study is a double-blind, placebo-controlled trial at 150 sites in 35 countries. We enrolled patients aged 18 years or older with active rheumatoid arthritis for 3 months or longer, who had received csDMARDs for at least 3 months with a stable dose for at least 4 weeks before study entry, and had an inadequate response to at least one of the following csDMARDs: methotrexate, sulfasalazine, or leflunomide...
June 12, 2018: Lancet
https://www.readbyqxmd.com/read/29908563/cerebellar-liponeurocytoma-a-rare-entity-a-case-report
#2
Oliver Gembruch, Andreas Junker, Yahya Ahmadipour, Ulrich Sure, Elias Lemonas
BACKGROUND: Cerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation with foci of lipomatous differentiation. Liponeurocytoma develops in adult patients and is defined in the World Health Organization classification of 2016 as a rare benign grade II tumor. CASE PRESENTATION: A 39-year-old Italian man presented to our department suffering from headache and nausea...
June 17, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29908105/phase-ii-trial-of-biweekly-cetuximab-and-irinotecan-as-third-line-therapy-for-pretreated-kras-exon-2-wild-type-colorectal-cancer
#3
Hiroki Osumi, Eiji Shinozaki, Tetsuo Mashima, Takeru Wakatsuki, Mitsukuni Suenaga, Takashi Ichimura, Mariko Ogura, Yumiko Ota, Izuma Nakayama, Daisuke Takahari, Keisho Chin, Yoshio Miki, Kensei Yamaguchi
Efficacy and safety of biweekly cetuximab plus irinotecan were evaluated to provide guidance for its use in Japan as third-line treatment for pretreated metastatic colorectal cancer patients harboring wild-type KRAS Exon 2. Objective response rate was used as primary endpoint based on an expected proportion of 0.23 with confidence width of 0.298 (95% confidence interval, 0.105-0.403), which showed 35 to be the minimal participant number. Forty patients, refractory to first- and second-line chemotherapy containing irinotecan, oxaliplatin, and fluoropyrimidine were enrolled...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29907226/paravertebral-block-associated-with-decreased-opioid-use-and-less-nausea-and-vomiting-after-reduction-mammaplasty
#4
David D Rivedal, Harry S Nayar, Jacqueline S Israel, Glen Leverson, Andrew J Schulz, Tamara Chambers, Ahmed M Afifi, Jocelyn M Blake, Samuel O Poore
BACKGROUND: In light of data finding that postoperative pain, nausea, and vomiting worsen outcomes, a renewed emphasis has been placed on optimizing the perioperative period. Use of preoperative paravertebral block (PVB) has been shown to reduce opioid administration and postoperative nausea and vomiting (PONV) in many surgical populations, though its role in reduction mammaplasty remains undefined. Therefore, we seek to evaluate PVB as an adjunct to general anesthesia (GA) for reduction mammaplasty...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907086/potential-risk-factors-and-prevalence-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-symptoms-in-cameroon
#5
Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga, Hubert Leundji
BACKGROUND: Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought to determine potential risk factors associated with seroprevalence of H. pylori among dyspepsia patients in Cameroon for a better management of the disease. METHODS: The study was carried out from August to December 2014 at Laquintinie Hospital and District Hospital of Bonassama in Douala metropolis...
June 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29906709/short-term-efficacy-and-tolerability-of-lurasidone-in-the-treatment-of-acute-schizophrenia-a-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Wei Zheng, Dong-Bin Cai, Xin-Hu Yang, Lu Li, Qing-E Zhang, Chee H Ng, Gabor S Ungvari, Xian-Bin Li, Yu-Ping Ning, Yu-Tao Xiang
BACKGROUND: Lurasidone, an azapirone derivative, is a novel second generation antipsychotic with potent binding affinity for dopamine D2, serotonin 5-HT2A , 5-HT7, 5-HT1A, and noradrenaline alpha2C receptors. This updated meta-analysis of randomized controlled trials (RCTs) examined the short-term efficacy and tolerability of lurasidone in the treatment of acute schizophrenia. METHODS: Double-blinded RCTs reporting on the short-term effects of lurasidone were included...
June 5, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29906570/randomized-placebo-controlled-phase-iii-trial-of-fosaprepitant-ondansetron-dexamethasone-fond-versus-fond-plus-olanzapine-fond-o-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-patients-with-hematologic-malignancies-receiving-highly-emetogenic
#7
Amber B Clemmons, Julianne Orr, Benjamin Andrick, Arpita Gandhi, Claude Sportes, David DeRemer
Evidence supports olanzapine for prophylaxis of chemotherapy-induced nausea/vomiting (CINV) for highly emetogenic chemotherapy (HEC); however, most studies focus on solid malignancies and single day regimens. A randomized, double-blinded, placebo-controlled trial was conducted to compare addition of olanzapine to triplet therapy (fosaprepitant, ondansetron, dexamethasone; FOND-O) versus triplet therapy alone (FOND) in preventing CINV in hematology patients receiving single and multi-day HEC and hematopoietic cell transplant (HCT) regimens (NCT02635984)...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29906236/the-effect-of-preparative-solid-food-status-on-the-occurrence-of-nausea-vomiting-and-aspiration-symptoms-in-enhanced-ct-examination-prospective-observational-study
#8
Xue Li, Heng Liu, Li Zhao, Junling Liu, Li Cai, Letian Zhang, Lei Liu, Weiguo Zhang
OBJECTIVES: To evaluate the correlation between preparative solid food status and the incidence of nausea, vomiting and aspiration symptoms in contrast-enhanced computed tomography (CT) examination, and to provide direction for standardizing the preparative dietary policies. METHODS: Patients who underwent routine enhanced CT examination at our hospital between June 2015 and June 2017 (110,836 cases) were enrolled and allocated into solid food fasting group (51,807 cases) and solid food non-fasting group (59,029 cases)...
June 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29906034/schmidt%C3%A2-s-syndrome-a-difficult-diagnosis-in-the-latin-american-context
#9
Claudia Barreda-Velit, Rodrigo Salcedo-Pereda, Jesús Ticona
Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. The diagnosis consists in the concomitant presentation of Addison disease, autoimmune thyroid disease and other autoimmune endocrinological conditions. The aim of this paper is to describe a case of Schmidt’s syndrome in the peruvian context and to analyze the difficulties in the diagnosis. Clinical case: We present the case of a 43-year-old woman that presents to the emergency room with headache, nausea, vomits and a “syncope episode”...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905976/pharmacokinetics-safety-and-tolerability-of-rolapitant-administered-intravenously-following-single-ascending-and-multiple-ascending-doses-in-healthy-subjects
#10
Xiaodong Wang, Zhi-Yi Zhang, Jing Wang, Dan Powers, Sujata Arora, Sharon Lu, Vikram Kansra
Rolapitant is a selective and long-acting neurokinin-1 receptor antagonist approved in an oral formulation in combination with dexamethasone and a 5-hydroxytryptamine type 3 receptor antagonist for the prevention of delayed chemotherapy-induced nausea and vomiting in adults. The pharmacokinetic and safety profiles of intravenous (IV) rolapitant were evaluated in two open-label, phase 1 trials in healthy subjects. Single ascending dose (SAD) and multiple ascending dose studies were conducted in one trial (PR-11-5012-C), and a supratherapeutic SAD study was conducted in a separate trial (PR-11-5022-C)...
June 15, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29905918/ocular-symptoms-and-signs-of-chikungunya-fever-in-puerto-rico
#11
Jan P Ulloa-Padilla, Pedro J Dávila, Natalio J Izquierdo, Omar García-Rodríguez, Ivonne Z Jiménez
OBJECTIVE: To determine what ocular symptoms and signs are most common and if there are any associations with comorbid conditions in patients with Chikungunya fever. METHODS: A retrospective data review and analysis of the ocular symptomatology of 139 patients with Chikungunya fever who visited a local emergency room from August through September 2014. Frequencies were calculated, and Pearson's chisquare test employed. All the patients were confirmed as having Chikungunya with IgM (ELISA) before admittance into the study...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905898/phase-i-study-of-the-anti-%C3%AE-5%C3%AE-1-monoclonal-antibody-mint1526a-with-or-without-bevacizumab-in-patients-with-advanced-solid-tumors
#12
Colin D Weekes, Lee S Rosen, Anna Capasso, Kit Man Wong, Weilan Ye, Maria Anderson, Bruce McCall, Jill Fredrickson, Eric Wakshull, Steve Eppler, Quyen Shon-Nguyen, Rupal Desai, Mahrukh Huseni, Priti S Hegde, Tony Pourmohamad, Ina Rhee, Alberto Bessudo
PURPOSE: MINT1526A is a monoclonal antibody that blocks the interaction of integrin alpha 5 beta 1 (α5β1) with its extracellular matrix ligands. This phase I study evaluated the safety and pharmacokinetics of MINT1526A with or without bevacizumab in patients with advanced solid tumors. METHODS: MINT1526A was administered every 3 weeks (Q3W) as monotherapy (arm 1) or in combination with bevacizumab 15 mg/kg, Q3W (arm 2). Each arm included a 3 + 3 dose-escalation stage and a dose-expansion stage...
June 15, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29905841/posterior-fossa-craniotomy-for-adherent-fourth-ventricle-neurocysticercosis
#13
Lynze R Franko, Balaji Pandian, Avneesh Gupta, Luis E Savastano, Kevin S Chen, James Riddell, Daniel A Orringer
BACKGROUND AND IMPORTANCE: Neurocysticercosis (NCC) is an infectious helminthic disease often presenting in patients who have immigration or travel history from areas where NCC is endemic. Fourth ventricle cysts from NCC pose a unique treatment challenge, as there is little consensus on the best treatment. This case study describes the treatment of a patient with fourth ventricle neurocysticercosis (FVNCC), examines the therapeutic decision-making, and provides a video of a posterior fossa craniotomy (PFC) resection of a degenerative cyst...
June 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29905617/impact-of-clinical-guidelines-on-revisits-after-ambulatory-pediatric-adenotonsillectomy
#14
Helen H Lee, Nicholas M Dalesio, Anthony T Lo Sasso, William C Van Cleve
BACKGROUND: Pediatric adenotonsillectomies are common and carry known risks of potentially severe complications. Complications that require a revisit, to either the emergency department or hospital readmission, increase costs and may be tied to lower reimbursements by federal programs. In 2011 and 2012, recommendations by pediatric and surgical organizations regarding selection of candidates for ambulatory procedures were issued. We hypothesized that guideline-associated changes in practice patterns would lower the odds of revisits...
June 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29904615/acute-pericarditis-as-a-presentation-of-adrenal-insufficiency
#15
Sukesh Manthri, Sindhura Bandaru, Abdisamad Ibrahim, Chaitanya K Mamillapalli
Acute pericarditis as a presenting sign of adrenal insufficiency is rarely reported. We present a rare case that highlights pericarditis as a clinical presentation of secondary adrenal insufficiency later complicated by cardiac tamponade. A 44-year-old lady who presented to the hospital with a one-day history of pleuritic chest pain and shortness of breath. In the emergency room, she had a blood pressure of 70/35 mmHg. Laboratory evaluation revealed white blood cell count of 16.08 k/cumm with neutrophilia, normal renal function and elevated troponin (0...
April 13, 2018: Curēus
https://www.readbyqxmd.com/read/29904455/high-grade-atrioventricular-block-in-von-recklinghausen-disease-a-rare-phenomenon
#16
Glenmore Lasam, Marcelina Lasam
A case of a 73-year-old woman with a history of von Recklinghausen disease (neurofibromatosis type 1) who presented initially with a gradual onset of shortness of breath and lightheadedness with no associated fever, chills, angina, palpitations, cough, weight loss, night sweats, nausea, vomiting, or constipation. She was found to be severely bradycardic and in third degree atrioventricular block by her primary care physician. She was admitted in the hospital because of intermittent bouts of lightheadedness and progression of the shortness of breath...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904454/a-rare-case-of-native-mitral-valve-bacillus-cereus-endocarditis-culminating-into-a-cerebrovascular-infarction
#17
Bibai Ren, Glenmore Lasam
We report a case of a 56-year-old man who presented initially with a sudden onset of right-sided facial droop and weakness, aphasia, and confusion with no associated fever, chills, syncope, fatigue, weight loss, night sweats, nausea, vomiting, diarrhea, odontalgia, palpitations, cough, or dyspnea. Code stroke was called and the patient received tissue plasminogen activator (tPA) with subsequent resolution of his symptoms. Cranial magnetic resonance imaging showed left frontal punctate cortical restricted diffusion consistent with subacute to acute infarction...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29903673/clinician-observed-and-patient-reported-toxicities-and-their-association-with-poor-tolerance-to-therapy-in-older-patients-with-head-and-neck-or-lung-cancer-treated-with-curative-radiotherapy
#18
Dominic H Moon, Bhishamjit S Chera, Allison M Deal, Yue Wang, Hyman B Muss, Noam A VanderWalde
OBJECTIVES: The agreement between clinician- and patient-reported toxicities and their association with poor tolerance to therapy were assessed in an older population receiving curative radiotherapy (RT). MATERIALS AND METHODS: Patients ≥ 65 years old with newly-diagnosed head and neck or lung cancer receiving curative RT ± chemotherapy were enrolled on a prospective, observational study. Agreement between clinician (CTCAEv4.02) and patient (PRO-CTCAE, EORTC QLQ-C30) report of toxicities were assessed at baseline, during treatment, and post-treatment...
June 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29903459/single-injection-adductor-canal-block-with-multiple-adjuvants-provides-equivalent-analgesia-when-compared-with-continuous-adductor-canal-blockade-for-primary-total-knee-arthroplasty-a-double-blinded-randomized-controlled-equivalency-trial
#19
James D Turner, Sean W Dobson, Daryl S Henshaw, Christopher J Edwards, Robert S Weller, Jon W Reynolds, Gregory B Russell, Jonathan D Jaffe
BACKGROUND: Peripheral nerve blockade is used to provide analgesia for patients undergoing total knee arthroplasty. This study compared a single-injection adductor canal block (SACB) with adjuvants to continuous adductor canal blockade (CACB). The hypothesis was that the 2 groups would have equivalent analgesia at 30 hours after neural blockade. METHODS: This was a double-blinded, randomized, controlled, equivalency trial. Sixty patients were randomized to either the SACB group (20 mL of 0...
May 24, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29902610/modified-extended-suboccipital-subtonsillar-clipping-of-a-ruptured-proximal-pica-aneurysm-technical-note-with-relevant-anatomical-demonstration
#20
Alberto Di Somma, Paloma Cancela, Magdalena Olivares, Teresa Somma, Antonio López-González, Alvaro Campero, Juan Emmerich, Javier Márquez-Rivas
BACKGROUND: and importance: Lesions located lateral to the lower brainstem, such as proximal posterior inferior cerebellar artery (PICA) aneurysms, are surgically challenging. In this study we report a case of a patient with a left proximal PICA aneurysm that was successfully clipped via a so-called "extended" suboccipital subtonsillar approach, which allowed to obtain proper vascular control without removal of the atlas. The anatomy relevant for this approach has been studied...
June 11, 2018: World Neurosurgery
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