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https://www.readbyqxmd.com/read/28214717/an-interactive-medical-image-segmentation-framework-using-iterative-refinement
#1
Pratik Kalshetti, Manas Bundele, Parag Rahangdale, Dinesh Jangra, Chiranjoy Chattopadhyay, Gaurav Harit, Abhay Elhence
Segmentation is often performed on medical images for identifying diseases in clinical evaluation. Hence it has become one of the major research areas. Conventional image segmentation techniques are unable to provide satisfactory segmentation results for medical images as they contain irregularities. They need to be pre-processed before segmentation. In order to obtain the most suitable method for medical image segmentation, we propose MIST (Medical Image Segmentation Tool), a two stage algorithm. The first stage automatically generates a binary marker image of the region of interest using mathematical morphology...
February 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28212616/general-practitioners-views-on-long-term-prescription-and-use-of-problematic-and-potentially-inappropriate-medication-for-oldest-old-patients-a-qualitative-interview-study-with-gps-cim-triad-study
#2
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G Riedel-Heller, Wolfgang Maier, Frank Jessen, Martin Scherer
BACKGROUND: Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM. METHODS: As part of the CIM-TRIAD study, we conducted semi-structured, qualitative interviews with 47 general practitioners, discussing 25 patients with and 22 without PIM (according to the PRISCUS list)...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28212602/happi-2-a-comprehensive-and-high-quality-map-of-human-annotated-and-predicted-protein-interactions
#3
Jake Y Chen, Ragini Pandey, Thanh M Nguyen
BACKGROUND: Human protein-protein interaction (PPI) data is essential to network and systems biology studies. PPI data can help biochemists hypothesize how proteins form complexes by binding to each other, how extracellular signals propagate through post-translational modification of de-activated signaling molecules, and how chemical reactions are coupled by enzymes involved in a complex biological process. Our capability to develop good public database resources for human PPI data has a direct impact on the quality of future research on genome biology and medicine...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28211190/technology-to-engage-hospitalised-patients-in-their-nutrition-care-a-qualitative-study-of-usability-and-patient-perceptions-of-an-electronic-foodservice-system
#4
S Roberts, A P Marshall, R Gonzalez, W Chaboyer
BACKGROUND: Active patient involvement in nutrition care may improve dietary intakes in hospital. Our team is developing an innovative programme allowing patients to self-assess and self-monitor their nutrition at the bedside. The present study aimed to assess usability and patient perceptions of an electronic foodservice system (EFS) for participating in nutrition care. METHODS: This qualitative study was conducted in an Australian tertiary hospital. Participants were sampled purposively and included patients who were able to provide informed consent and communicate in English...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28209561/co-creating-and-evaluating-a-web-app-mapping-real-world-health-care-services-for-students-the-servi-share-protocol
#5
Ilaria Montagni, Emmanuel Langlois, Jérôme Wittwer, Christophe Tzourio
BACKGROUND: University students aged 18-30 years are a population group reporting low access to health care services, with high rates of avoidance and delay of medical care. This group also reports not having appropriate information about available health care services. However, university students are at risk for several health problems, and regular medical consultations are recommended in this period of life. New digital devices are popular among the young, and Web-apps can be used to facilitate easy access to information regarding health care services...
February 16, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28208763/iterative-development-of-an-online-dietary-recall-tool-intake24
#6
Emma Simpson, Jennifer Bradley, Ivan Poliakov, Dan Jackson, Patrick Olivier, Ashley J Adamson, Emma Foster
Collecting large-scale population data on dietary intake is challenging, particularly when resources and funding are constrained. Technology offers the potential to develop novel ways of collecting large amounts of dietary information while making it easier, more convenient, intuitive, and engaging for users. INTAKE24 is an online multiple pass 24 h dietary recall tool developed for use in national food and nutrition surveys. The development of INTAKE24 was a four-stage iterative process of user interaction and evaluation with the intended end users, 11-24 years old...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28207882/improving-brain-computer-interface-research-through-user-involvement-the-transformative-potential-of-integrating-civil-society-organisations-in-research-projects
#7
Bernd Carsten Stahl, Kutoma Wakunuma, Stephen Rainey, Christian Hansen
Research on Brain Computer Interfaces (BCI) often aims to provide solutions for vulnerable populations, such as individuals with diseases, conditions or disabilities that keep them from using traditional interfaces. Such research thereby contributes to the public good. This contribution to the public good corresponds to a broader drive of research and funding policy that focuses on promoting beneficial societal impact. One way of achieving this is to engage with the public. In practical terms this can be done by integrating civil society organisations (CSOs) in research...
2017: PloS One
https://www.readbyqxmd.com/read/28207400/a-low-cost-adaptive-balance-training-platform-for-stroke-patients-a-usability-study
#8
Sunny Verma, Deepesh Kumar, Animesh Kumawat, Anirban Dutta, Uttama Lahiri
Stroke patients usually suffer from asymmetric posture due to hemi-paresis that can result in reduced postural controllability leading to a balance deficit. This deficit increases the risk of falls, which often makes them dependent on caregivers for community ambulation, thus deteriorating their quality of life. Conventional balance training involves rehabilitation exercises performed under physiotherapist's supervision where the scarcity of trained professionals as well as the cost of clinic-based rehabilitation programs can deter stroke survivors from undergoing regular balance training...
February 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28204845/mirnas-target-databases-developmental-methods-and-target-identification-techniques-with-functional-annotations
#9
REVIEW
Nagendra Kumar Singh
PURPOSE: microRNA (miRNA) regulates diverse biological mechanisms and metabolisms in plants and animals. Thus, the discoveries of miRNA has revolutionized the life sciences and medical research.The miRNA represses and cleaves the targeted mRNA by binding perfect or near perfect or imperfect complementary base pairs by RNA-induced silencing complex (RISC) formation during biogenesis process. One miRNA interacts with one or more mRNA genes and vice versa, hence takes part in causing various diseases...
February 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28198540/subadult-sex-estimation-from-diaphyseal-dimensions
#10
Kyra E Stull, Ericka N L'Abbé, Stephen D Ousley
OBJECTIVES: Many studies on subadult sex estimation focus on elements that express sexually dimorphic features in adults. In contrast, diaphyseal dimensions have been shown to display sex-specific differences prior to adolescence. The current study evaluates the use of diaphyseal dimensions in subadult sex estimation. MATERIALS AND METHODS: Eighteen postcranial measurements from six long bones were collected on Lodox Statscan radiographic images of 1,310 modern South African children between birth and 12 years of age...
February 15, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28198356/a-comparison-study-of-visually-stimulated-brain-computer-and-eye-tracking-interfaces
#11
Kaori Suefusa, Toshihisa Tanaka
OBJECTIVE: Brain--computer interfacing (BCI) based on visual stimuli detects the target on a screen on which a user is focusing. The detection of the gazing target can be achieved by tracking gaze positions with a video camera, which is called eye tracking or eye tracking interfaces (ETIs). Both types of interfaces have been developed in different communities. Thus, little work on the comprehensive comparison between these two types of interfaces has been reported. This paper quantitatively compares the performance of these two interfaces on the same experimental platform...
February 15, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28197092/bci-control-of-heuristic-search-algorithms
#12
Marc Cavazza, Gabor Aranyi, Fred Charles
The ability to develop Brain-Computer Interfaces (BCI) to Intelligent Systems would offer new perspectives in terms of human supervision of complex Artificial Intelligence (AI) systems, as well as supporting new types of applications. In this article, we introduce a basic mechanism for the control of heuristic search through fNIRS-based BCI. The rationale is that heuristic search is not only a basic AI mechanism but also one still at the heart of many different AI systems. We investigate how users' mental disposition can be harnessed to influence the performance of heuristic search algorithm through a mechanism of precision-complexity exchange...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28193871/optimizing-virtual-reality-for-all-users-through-gaze-contingent-and-adaptive-focus-displays
#13
Nitish Padmanaban, Robert Konrad, Tal Stramer, Emily A Cooper, Gordon Wetzstein
From the desktop to the laptop to the mobile device, personal computing platforms evolve over time. Moving forward, wearable computing is widely expected to be integral to consumer electronics and beyond. The primary interface between a wearable computer and a user is often a near-eye display. However, current generation near-eye displays suffer from multiple limitations: they are unable to provide fully natural visual cues and comfortable viewing experiences for all users. At their core, many of the issues with near-eye displays are caused by limitations in conventional optics...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193506/evaluation-of-genemarker-%C3%A2-hts-for-improved-alignment-of-mtdna-mps-data-haplotype-determination-and-heteroplasmy-assessment
#14
Mitchell M Holland, Erica D Pack, Jennifer A McElhoe
Existing software has not allowed for effective alignment of mitochondrial (mt) DNA sequence data generated using a massively parallel sequencing (MPS) approach, combined with the ability to perform a detailed assessment of the data. The regions of sequence that are typically difficult to align are homopolymeric stretches, isolated patterns of SNPs (single nucleotide polymorphisms), and INDELs (insertions/deletions). A custom software solution, GeneMarker(®) HTS, was developed and evaluated to address these limitations, and to provide a user-friendly interface for forensic practitioners and others interested in mtDNA analysis of MPS data...
February 6, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28193497/i-act-therefore-i-err-eeg-correlates-of-success-and-failure-in-a-virtual-throwing-game
#15
Boris Yazmir, Miriam Reiner
What are the neural responses to success and failure in a throwing task? To answer this question, we compared Event Related Potentials (ERPs) correlated with success and failure during a highly-ecological-virtual game. Participants played a tennis-like game in an immersive 3D virtual world, against a computer player, by controlling a virtual tennis racket with a force feedback robotic arm. Results showed that success, i.e. hitting the target, and failure, by missing the target, evoked ERP's that differ by peak, latencies, scalp signal distributions, sLORETA source estimation, and time-frequency patterns...
February 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28193066/proof-of-principle-of-rtlc-an-open-source-software-developed-for-image-evaluation-and-multivariate-analysis-of-planar-chromatograms
#16
Dimitri Fichou, Petar Ristivojević, Gertrud E Morlock
High-performance thin-layer chromatography (HPTLC) is an advantageous analytical technique for analysis of complex samples. Combined with multivariate data analysis, it turns out to be a powerful tool for profiling of many samples in parallel. So far, chromatogram analysis has been time-consuming and required the application of at least two software packages to convert HPTLC chromatograms into a numerical data matrix. Hence, this study aimed to develop a powerful, all in one open-source software for user-friendly image processing and multivariate analysis of HPTLC chromatograms...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191571/a-computer-based-prediction-platform-for-the-reaction-of-ozone-with-organic-compounds-in-aqueous-solution-kinetics-and-mechanisms
#17
Minju Lee, Lorenz C Blum, Emanuel Schmid, Kathrin Fenner, Urs von Gunten
Ozonation of secondary wastewater effluents can reduce the discharge of micropollutants by transforming their chemical structures. Therefore, a better understanding of the formation of transformation products during ozonation is important. In this study, a computer-based prediction platform for the kinetics and mechanisms of the reactions of ozone with organic compounds was developed to enable in silico predictions of transformation products. With the developed prediction platform, reaction kinetics expressed as second-order rate constants for the reactions of ozone with selected organic compounds (kO3, M(-1) s(-1)) can be predicted based on an adapted kO3 prediction model from a previous study (Lee et al...
February 13, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28190994/suepdf-a-program-to-obtain-quantitative-pair-distribution-functions-from-electron-diffraction-data
#18
Dung Trung Tran, Gunnar Svensson, Cheuk-Wai Tai
SUePDF is a graphical user interface program written in MATLAB to achieve quantitative pair distribution functions (PDFs) from electron diffraction data. The program facilitates structural studies of amorphous materials and small nanoparticles using electron diffraction data from transmission electron microscopes. It is based on the physics of electron scattering as well as the total scattering methodology. A method of background modeling is introduced to treat the intensity tail of the direct beam, inelastic scattering and incoherent multiple scattering...
February 1, 2017: Journal of Applied Crystallography
https://www.readbyqxmd.com/read/28188483/integrating-cad-modules-in-a-pacs-environment-using-a-wide-computing-infrastructure
#19
Jorge J Suárez-Cuenca, Amara Tilve, Ricardo López, Gonzalo Ferro, Javier Quiles, Miguel Souto
PURPOSE: The aim of this paper is to describe a project designed to achieve a total integration of different CAD algorithms into the PACS environment by using a wide computing infrastructure. METHODS: The aim is to build a system for the entire region of Galicia, Spain, to make CAD accessible to multiple hospitals by employing different PACSs and clinical workstations. The new CAD model seeks to connect different devices (CAD systems, acquisition modalities, workstations and PACS) by means of networking based on a platform that will offer different CAD services...
February 10, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28187703/ihms-a-database-integrating-human-histone-modification-data-across-developmental-stages-and-tissues
#20
Yanglan Gan, Han Tao, Jihong Guan, Shuigeng Zhou
BACKGROUND: Differences in chromatin states are critical to the multiplicity of cell states. Recently genome-wide histone modification maps of diverse human developmental stages and tissues have been charted. DESCRIPTION: To facilitate the investigation of epigenetic dynamics and regulatory mechanisms in cellular differentiation processes, we developed iHMS, an integrated human histone modification database that incorporates massive histone modification maps spanning different developmental stages, lineages and tissues ( http://www...
February 11, 2017: BMC Bioinformatics
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