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https://www.readbyqxmd.com/read/28095951/simulated-microgravity-effects-on-nonsmall-cell-lung-cancer-cell-proliferation-and-migration
#1
Jae Ho Chung, Chi Bum Ahn, Kuk Hui Son, Eunjue Yi, Ho Sung Son, Han-Sung Kim, Sung Ho Lee
BACKGROUND: Despite improvements in medical technology, lung cancer metastasis remains a global health problem. The effects of microgravity on cell morphology, structure, functions, and their mechanisms have been widely studied; however, the biological effects of simulated microgravity on the interaction between cells and its eventual influence on the characteristics of cancer cells are yet to be discovered. We examined the effects of simulated microgravity on the metastatic ability of different lung cancer cells using a random positioning machine...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28092029/an-efficient-semi-supervised-learning-approach-to-predict-sh2-domain-mediated-interactions
#2
Kousik Kundu, Rolf Backofen
Src homology 2 (SH2) domain is an important subclass of modular protein domains that plays an indispensable role in several biological processes in eukaryotes. SH2 domains specifically bind to the phosphotyrosine residue of their binding peptides to facilitate various molecular functions. For determining the subtle binding specificities of SH2 domains, it is very important to understand the intriguing mechanisms by which these domains recognize their target peptides in a complex cellular environment. There are several attempts have been made to predict SH2-peptide interactions using high-throughput data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28080293/proximal-contact-repair-of-complex-amalgam-restorations
#3
M N Zguri, J A Casey, J P Jessup, K S Vandewalle
The carving of a complex amalgam restoration may occasionally result in light proximal contact with the adjacent tooth. The purpose of this study was to investigate the strength of complex amalgam restorations repaired with a proximal slot amalgam preparation. Extracted human third molars of similar coronal size were sectioned 1 mm apical to the height of the contour using a saw and were randomly distributed into 9 groups of 10 teeth each. One pin was placed at each line angle of the flattened dentinal tooth surface...
January 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28068295/support-vector-machines-to-detect-physiological-patterns-for-eeg-and-emg-based-human-computer-interaction-a-review
#4
L R Quitadamo, F Cavrini, L Sbernini, F Riillo, L Bianchi, S Seri, G Saggio
Support vector machines (SVMs) are widely used classifiers for detecting physiological patterns in human-computer interaction (HCI). Their success is due to their versatility, robustness and large availability of free dedicated toolboxes. Frequently in the literature, insufficient details about the SVM implementation and/or parameters selection are reported, making it impossible to reproduce study analysis and results. In order to perform an optimized classification and report a proper description of the results, it is necessary to have a comprehensive critical overview of the applications of SVM...
January 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28067801/easy-handling-of-sensors-and-actuators-over-tcp-ip-networks-by-open-source-hardware-software
#5
Andrés Mejías, Reyes S Herrera, Marco A Márquez, Antonio José Calderón, Isaías González, José Manuel Andújar
There are several specific solutions for accessing sensors and actuators present in any process or system through a TCP/IP network, either local or a wide area type like the Internet. The usage of sensors and actuators of different nature and diverse interfaces (SPI, I2C, analogue, etc.) makes access to them from a network in a homogeneous and secure way more complex. A framework, including both software and hardware resources, is necessary to simplify and unify networked access to these devices. In this paper, a set of open-source software tools, specifically designed to cover the different issues concerning the access to sensors and actuators, and two proposed low-cost hardware architectures to operate with the abovementioned software tools are presented...
January 5, 2017: Sensors
https://www.readbyqxmd.com/read/28052254/pan-cancer-immunogenomic-analyses-reveal-genotype-immunophenotype-relationships-and-predictors-of-response-to-checkpoint-blockade
#6
Pornpimol Charoentong, Francesca Finotello, Mihaela Angelova, Clemens Mayer, Mirjana Efremova, Dietmar Rieder, Hubert Hackl, Zlatko Trajanoski
The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the majority of patients do not respond to immunotherapy, making the identification of predictive markers and the mechanisms of resistance an area of intense research. To increase our understanding of tumor-immune cell interactions, we characterized the intratumoral immune landscapes and the cancer antigenomes from 20 solid cancers and created The Cancer Immunome Atlas (https://tcia...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28046974/su-g-jep3-08-robotic-system-for-ultrasound-tracking-in-radiation-therapy
#7
I Kuhlemann, P Jauer, A Schweikard, F Ernst
PURPOSE: For safe and accurate real-time tracking of tumors for IGRT using 4D ultrasound, it is necessary to make use of novel, high-end force-sensitive lightweight robots designed for human-machine interaction. Such a robot will be integrated into an existing robotized ultrasound system for non-invasive 4D live tracking, using a newly developed real-time control and communication framework. METHODS: The new KUKA LWR iiwa robot is used for robotized ultrasound real-time tumor tracking...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027952/internet-addiction-in-adolescence-neurobiological-psychosocial-and-clinical-issues
#8
REVIEW
L Cerniglia, F Zoratto, S Cimino, G Laviola, M Ammaniti, W Adriani
Despite it has not been formally included in DSM-5 as a disorder, 'Internet addiction (IA)' has become a worldwide issue. It can be broadly defined as a non-chemical, behavioral addiction, which involves human-machine interaction. We pinpoint it as an "instrumental" form of social interaction (i.e. mediated by machines), a notion that appears useful for the sake of possible preclinical modeling. The features of Internet use reveals as addictive when this comes at the expense of genuine real-life sociability, with an overlap towards the hikikomori phenomenon (i...
December 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28024389/tribotronic-transistor-array-as-an-active-tactile-sensing-system
#9
Zhi Wei Yang, Yaokun Pang, Limin Zhang, Cunxin Lu, Jian Chen, Tao Zhou, Chi Zhang, Zhong Lin Wang
Large-scale tactile sensor arrays are of great importance in flexible electronics, human-robot interaction, and medical monitoring. In this paper, a flexible 10 × 10 tribotronic transistor array (TTA) is developed as an active tactile sensing system by incorporating field-effect transistor units and triboelectric nanogenerators into a polyimide substrate. The drain-source current of each tribotronic transistor can be individually modulated by the corresponding external contact, which has induced a local electrostatic potential to act as the conventional gate voltage...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28018838/a-motion-sensing-based-framework-for-robotic-manipulation
#10
Hao Deng, Zeyang Xia, Shaokui Weng, Yangzhou Gan, Peng Fang, Jing Xiong
To data, outside of the controlled environments, robots normally perform manipulation tasks operating with human. This pattern requires the robot operators with high technical skills training for varied teach-pendant operating system. Motion sensing technology, which enables human-machine interaction in a novel and natural interface using gestures, has crucially inspired us to adopt this user-friendly and straightforward operation mode on robotic manipulation. Thus, in this paper, we presented a motion sensing-based framework for robotic manipulation, which recognizes gesture commands captured from motion sensing input device and drives the action of robots...
2016: Robotics and Biomimetics
https://www.readbyqxmd.com/read/28005908/a-machine-learning-approach-for-using-the-postmortem-skin-microbiome-to-estimate-the-postmortem-interval
#11
Hunter R Johnson, Donovan D Trinidad, Stephania Guzman, Zenab Khan, James V Parziale, Jennifer M DeBruyn, Nathan H Lents
Research on the human microbiome, the microbiota that live in, on, and around the human person, has revolutionized our understanding of the complex interactions between microbial life and human health and disease. The microbiome may also provide a valuable tool in forensic death investigations by helping to reveal the postmortem interval (PMI) of a decedent that is discovered after an unknown amount of time since death. Current methods of estimating PMI for cadavers discovered in uncontrolled, unstudied environments have substantial limitations, some of which may be overcome through the use of microbial indicators...
2016: PloS One
https://www.readbyqxmd.com/read/28000607/polychromatic-ssvep-stimuli-with-subtle-flickering-adapted-to-brain-display-interactions
#12
Yu-Yi Chien, Fang-Cheng Lin, John Zao, Ching-Chi Chou, Yi-Pai Huang, Heng-Yuan Kuo, Yijun Wang, Tzyy-Ping Jung, Han-Ping D Shieh
OBJECTIVE: Interactive displays armed with natural user interfaces (NUIs) will likely lead the next breakthrough in consumer electronics, and brain-computer interfaces (BCIs) are often regarded as the ultimate NUI-enabling machines to respond to human emotions and mental states. Steady-state visual evoked potentials (SSVEPs) are a commonly used BCI modality due to the ease of detection and high information transfer rates. However, the presence of flickering stimuli may cause user discomfort and can even induce migraines and seizures...
December 21, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27974556/rplp1-and-rplp2-are-essential-flavivirus-host-factors-that-promote-early-viral-protein-accumulation
#13
Rafael K Campos, Benjamin Wong, Xuping Xie, Yi-Fan Lu, Pei-Yong Shi, Julien Pompon, Mariano A Garcia-Blanco, Shelton S Bradrick
: The Flavivirus genus contains several arthropod-borne viruses that pose global health threats, including dengue viruses (DENV), yellow fever virus (YFV) and Zika virus (ZIKV). In order to understand how these viruses replicate in human cells, we previously conducted genome-scale RNAi screens to identify candidate host factors. In these screens we identified ribosomal proteins RPLP1 and RPLP2 (RPLP1/2) to be among the most crucial putative host factors required for DENV and YFV infection...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27965104/identification-of-risk-pathways-and-functional-modules-for-coronary-artery-disease-based-on-genome-wide-snp-data
#14
Xiang Zhao, Yi-Zhao Luan, Xiaoyu Zuo, Ye-Da Chen, Jiheng Qin, Lv Jin, Yiqing Tan, Meihua Lin, Naizun Zhang, Yan Liang, Shao-Qi Rao
Coronary artery disease (CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism (SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium (WTCCC) SNP datasets of CAD and control samples were used to assess the joint effect of multiple genetic variants at the pathway level, using logistic kernel machine regression model...
December 2016: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/27956633/neuroadaptive-technology-enables-implicit-cursor-control-based-on-medial-prefrontal-cortex-activity
#15
Thorsten O Zander, Laurens R Krol, Niels P Birbaumer, Klaus Gramann
The effectiveness of today's human-machine interaction is limited by a communication bottleneck as operators are required to translate high-level concepts into a machine-mandated sequence of instructions. In contrast, we demonstrate effective, goal-oriented control of a computer system without any form of explicit communication from the human operator. Instead, the system generated the necessary input itself, based on real-time analysis of brain activity. Specific brain responses were evoked by violating the operators' expectations to varying degrees...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27918593/observing-consistency-in-online-communication-patterns-for-user-re-identification
#16
Ikuesan Richard Adeyemi, Shukor Abd Razak, Mazleena Salleh, Hein S Venter
Comprehension of the statistical and structural mechanisms governing human dynamics in online interaction plays a pivotal role in online user identification, online profile development, and recommender systems. However, building a characteristic model of human dynamics on the Internet involves a complete analysis of the variations in human activity patterns, which is a complex process. This complexity is inherent in human dynamics and has not been extensively studied to reveal the structural composition of human behavior...
2016: PloS One
https://www.readbyqxmd.com/read/27917105/eeg-negativity-in-fixations-used-for-gaze-based-control-toward-converting-intentions-into-actions-with-an-eye-brain-computer-interface
#17
Sergei L Shishkin, Yuri O Nuzhdin, Evgeny P Svirin, Alexander G Trofimov, Anastasia A Fedorova, Bogdan L Kozyrskiy, Boris M Velichkovsky
We usually look at an object when we are going to manipulate it. Thus, eye tracking can be used to communicate intended actions. An effective human-machine interface, however, should be able to differentiate intentional and spontaneous eye movements. We report an electroencephalogram (EEG) marker that differentiates gaze fixations used for control from spontaneous fixations involved in visual exploration. Eight healthy participants played a game with their eye movements only. Their gaze-synchronized EEG data (fixation-related potentials, FRPs) were collected during game's control-on and control-off conditions...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27910886/sequential-information-in-a-great-ape-utterance
#18
Pawel Fedurek, Klaus Zuberbühler, Christoph D Dahl
Birdsong is a prime example of acoustically sophisticated vocal behaviour, but its complexity has evolved mainly through sexual selection to attract mates and repel sexual rivals. In contrast, non-human primate calls often mediate complex social interactions, but are generally regarded as acoustically simple. Here, we examine arguably the most complex call in great ape vocal communication, the chimpanzee (Pan troglodytes schweinfurthii) 'pant hoot'. This signal consists of four acoustically distinct phases: introduction, build-up, climax and let-down...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895194/systematic-characterization-and-prediction-of-human-hypertension-genes
#19
Yan-Hui Li, Gai-Gai Zhang, Nanping Wang
Hypertension is a major cardiovascular risk factor and accounts for a large part of cardiovascular mortality. In this work, we analyzed the properties of hypertension genes and found that when compared with genes not yet known to be involved in hypertension regulation, known hypertension genes display distinguishing features: (1) hypertension genes tend to be located at network center; (2) hypertension genes tend to interact with each other; and (3) hypertension genes tend to enrich in certain biological processes and show certain phenotypes...
November 28, 2016: Hypertension
https://www.readbyqxmd.com/read/27881783/multivariate-brain-prediction-of-heart-rate-and-skin-conductance-responses-to-social-threat
#20
Hedwig Eisenbarth, Luke J Chang, Tor D Wager
: Psychosocial stressors induce autonomic nervous system (ANS) responses in multiple body systems that are linked to health risks. Much work has focused on the common effects of stress, but ANS responses in different body systems are dissociable and may result from distinct patterns of cortical-subcortical interactions. Here, we used machine learning to develop multivariate patterns of fMRI activity predictive of heart rate (HR) and skin conductance level (SCL) responses during social threat in humans (N = 18)...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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