keyword
MENU ▼
Read by QxMD icon Read
search

Addiction syndrome

keyword
https://www.readbyqxmd.com/read/29139482/opioid-misuse-in-gastroenterology-and-non-opioid-management-of-abdominal-pain
#1
REVIEW
Eva Szigethy, Mitchell Knisely, Douglas Drossman
Opioids were one of the earliest classes of medications used for pain across a variety of conditions, but morbidity and mortality have been increasingly associated with their chronic use. Despite these negative consequences, chronic opioid use is increasing worldwide, with the USA and Canada having the highest rates. Chronic opioid use for noncancer pain can have particularly negative effects in the gastrointestinal and central nervous systems, including opioid-induced constipation, narcotic bowel syndrome, worsening psychopathology and addiction...
November 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29130600/opioid-dependence-and-pregnancy-in-early-twentieth-century-america
#2
Nathan Tauger
BACKGROUND AND AIMS: Research on Neonatal Abstinence Syndrome has prompted discussion over how to ensure best outcomes for pregnant women who use drugs and for drug-dependent newborns. Before Neonatal Abstinence Syndrome and the 1980s panic of "crack babies," turn-of-the-century American medical journals discussed infants born to drug-using mothers. This paper aimed to determine whether women who used drugs while pregnant in early twentieth-century America were subject to the stigma many face today...
November 11, 2017: Addiction
https://www.readbyqxmd.com/read/29125116/emerging-roles-of-histidine-triad-nucleotide-binding-protein-1-in-neuropsychiatric-diseases
#3
Yong-Hui Dang, Zhong-Wei Liu, Peng Liu, Jia-Bei Wang
The histidine triad nucleotide binding protein1(HINT1),which belongs to the histidine triad(HIT) enzyme superfamily,exerts its enzymic activities as hydrolase or transferase. Its physiological functions are still unclear. HINT1 protein is expressed in various tissues and plays an important role in transcription and signal transduction. Earlier studies have identified HINT1 as a haplo-insufficient tumor suppressor. Other evidences indicate that HINT1 is involved in a wide variety of physiological processes,some of which are irrelevant with its basic enzymic activities...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29115823/an-overview-of-the-clinical-uses-pharmacology-and-safety-of-modafinil
#4
Eric Murillo-Rodriguez, André Barciela Veras, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado
Modafinil (MOD) is a drug used for the management of excessive daytime sleepiness observed in several sleep disturbances such as shift work sleep disorder, obstructive sleep apnea, restless leg syndrome and narcolepsy. Additionally, a wide scope of medical uses of MOD have been described such as fatigue in subjects with depression as well as patients under chemotherapy. Moreover, there also appear to be a cognitive enhancer drug. In contrast, recent reports have indicated the risk of developing addiction to MOD...
November 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29112519/methadone-versus-buprenorphine-for-opioid-use-dependence-and-risk-of-neonatal-abstinence-syndrome
#5
Lara S Lemon, Steve N Caritis, Raman Venkataramanan, Robert W Platt, Lisa M Bodnar
BACKGROUND: Our objective was to estimate the association between methadone and neonatal abstinence syndrome compared with buprenorphine using a probabilistic bias analysis to account for unmeasured confounding by severity of addiction. METHODS: We used a cohort of live-born infants exposed in utero to methadone or buprenorphine for maternal opioid maintenance therapy at Magee-Womens Hospital in Pittsburgh, PA from 2013-2015 (n=716). We determined exposure and outcome status using pharmacy billing claims...
November 6, 2017: Epidemiology
https://www.readbyqxmd.com/read/29079542/aapt-diagnostic-criteria-for-chronic-abdominal-pelvic-and-urogenital-pain-irritable-bowel-syndrome
#6
QiQi Zhou, Ursula Wesselmann, Lynn Walker, Linda Lee, Lonnie Zeltzer, G Nicholas Verne
In conjuction with the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative strove to develop the characteristics of a diagnostic system useful for clinical and research purposes across disciplines and types of chronic pain conditions. Following the establishment of these characteristics, a working group of clinicians and clinical and basic scientists with expertise in abdominal, pelvic, and urogenital pain began generating core diagnostic criteria and defining the related extraintestinal somatic pain and other symptoms experienced by patients...
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29077140/-deep-brain-stimulation-in-psychiatry
#7
M Figee, C Bervoets, D Denys
BACKGROUND: Deep brain stimulation (DBS) is now used regularly to treat therapy-refractory obsessive-compulsive disorders, and is being applied experimentally for refractory depression, Tourette syndrome, addiction, eating disorders, post-traumatic stress disorder, autism and schizophrenia. AIM: To review the effects and mechanisms of dbs and to consider the future opportunities for this type of treatment in psychiatry. METHOD: We reviewed the literature using PubMed...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29070156/born-into-addiction-neonatal-abstinence-syndrome-and-pediatric-dentistry
#8
Jennifer L Cully
Drug overdose and opioid-involved deaths continue to increase across the United States. An end-condition related to opioid abuse is neonatal abstinence syndrome (NAS). The implications for pregnant or post-partum women using an opioid, whether prescribed or illicit, can have significant effects on their infant. First described in the 1970s, NAS is defined as a postnatal drug withdrawal syndrome that primarily occurs in opioid-exposed infants. There are no nationally accepted, evidence-based treatment protocols for these infants...
September 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29068826/opioid-addiction-in-pregnancy-does-depression-negatively-impact-adherence-with-prenatal-care
#9
Lauren Hensley, Suela Sulo, Sarah Kozmic, Barbara V Parilla
OBJECTIVE: We aimed to evaluate whether depression in pregnancy in women with opioid dependency negatively impacts adherence with prenatal care. METHODS: This was a retrospective chart analysis of opioid-dependent pregnant women over a 6-year period at 2 large referral and tertiary care centers. The primary outcome was adherence with prenatal care based on the concurrent diagnosis of depression. Adherence was assessed by looking at the number of observed versus expected prenatal visits...
October 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29057722/excessive-bodybuilding-as-pathology-a-first-neurophysiological-classification
#10
Moritz Julian Maier, Florian Benedikt Haeussinger, Martin Hautzinger, Andreas Jochen Fallgatter, Ann-Christine Ehlis
OBJECTIVES: Excessive Bodybuilding as a pathological syndrome has been classified based on two different theories: Bodybuilding as dependency or as muscle dysmorphic disorder (MDD). This study is a first attempt to find psychophysiological data supporting one of these classifications. METHODS: 24 participants (bodybuilders vs. healthy controls) were presented with pictures of bodies, exercise equipment or general reward stimuli in a control or experimental condition, and were measured with functional near-infrared spectroscopy (fNIRS)...
October 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29056155/corticotropin-releasing-factor-crf-and-addictive-behaviors
#11
Marisa Roberto, Samantha R Spierling, Dean Kirson, Eric P Zorrilla
Drug addiction is a complex disorder that is characterized by compulsivity to seek and take the drug, loss of control in limiting intake of the drug, and emergence of a withdrawal syndrome in the absence of the drug. The transition from casual drug use to dependence is mediated by changes in reward and brain stress functions and has been linked to a shift from positive reinforcement to negative reinforcement. The recruitment of brain stress systems mediates the negative emotional state produced by dependence that drives drug seeking through negative reinforcement mechanisms, defined as the "dark side" of addiction...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29049120/a-contemporary-medicolegal-analysis-of-outpatient-medication-management-in-chronic-pain
#12
Christopher R Abrecht, Ethan Y Brovman, Penny Greenberg, Ellen Song, James P Rathmell, Richard D Urman
BACKGROUND: Opioids are frequently used in chronic pain management but are associated with significant morbidity and mortality in some patient populations. An important avenue for identifying complications-including serious or rare complications-is the study of closed malpractice claims. The present study is intended to complement the existing closed claims literature by drawing on claims from a more recent timeframe through a partnership with a large malpractice carrier, the Controlled Risk Insurance Company (CRICO)...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29032922/serotonin-transporter-density-in-binge-eating-disorder-and-pathological-gambling-a-pet-study-with-11-c-madam
#13
Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Riitta Parkkola, Hannu Alho, Eveliina Arponen, Valtteri Kaasinen
Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear. Given the crucial role of serotonin in a number of psychiatric disorders, we aimed to compare brain serotonergic function among individuals with BED, PG and healthy controls. Seven BED patients, 13 PG patients and 16 healthy controls were scanned with high-resolution positron emission tomography (PET) using the serotonin transporter (SERT) tracer [(11)C]MADAM...
October 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29018160/dopamine-dysregulation-syndrome-in-parkinson-s-disease-a-systematic-review-of-published-cases
#14
Nicola Warren, Cullen O'Gorman, Alexander Lehn, Dan Siskind
OBJECTIVES: Dopamine dysregulation syndrome (DDS) is an uncommon complication of the treatment of Parkinson's disease, characterised by addictive behaviour and excessive use of dopaminergic medication. DDS may frequently go unrecognised or misdiagnosed. We aimed to clarify current understanding of presentation, risk factors, comorbidities and management of DDS. METHODS: Case reports were identified through a systematic search of databases (PubMed, Embase) with the following terms: dopaminergic dysregulation syndrome, hedonistic homeostatic dysregulation, dopamine/levodopa addiction...
October 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28990851/stability-study-of-a-clonidine-oral-solution-in-a-novel-vehicle-designed-for-pediatric-patients
#15
Arnaud Potier, Julien Voyat, Alain Nicolas
Clonidine hydrochloride is administered to opioid-addicted mothers' neonates to reduce neonatal abstinence syndrome. It is prescribed off-label to neonates at 0.5-1 µg/kg/6 h, alone or in combination. The commercially injectable form of clonidine-Catapressan(®) 0.15 mg/mL-is being orally given after an appropriate dilution in water. However, this practice is not suitable for a perfectly safe and accurate administration. The objectives were to design a 10 µg/mL oral solution of clonidine hydrochloride in Inorpha(®) and to study the stability of this solution by a validated stability-indicating liquid chromatography (LC) method...
October 24, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28974443/toxicological-aspects-of-the-interesterified-fat-from-processed-foods-influences-on-opioid-system-and-its-reward-effects-in-rats
#16
Laura H Milanesi, Karine Roversi, Caren T D Antoniazzi, Hecson J Segat, Maikel Kronbauer, Lívia F D'avila, Verônica T Dias, Marcel H M Sari, Raquel C S Barcelos, Luana H Maurer, Tatiana Emanuelli, Marilise E Burger, Fabíola Trevizol
Considering the high consumption of processed foods, interesterified fat (IF) has been used to replace trans fat, since it may harm nervous system functions. Opioids are intensely used to alleviate pain, and have a highly addictive potential. Therefore, their improper use is related to addiction, tolerance, and withdrawal syndrome. Wistar rats received soybean oil (SO) or IF during gestation, lactation and post-weaning until pups' adolescence. On post-natal day 39, animals received morphine (4 mg/kg i.p.) in the conditioned place preference (CPP) paradigm...
September 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28930612/genetic-addiction-risk-score-gars-%C3%A2-a-predictor-of-vulnerability-to-opioid-dependence
#17
Kenneth Blum, Amanda L C Chen, Panayotis K Thanos, Marcelo Febo, Zsolt Demetrovics, Kristina Dushaj, Abraham Kovoor, David Baron, David E Smith, Alphonso Kenison Roy III, Lyle Fried, Thomas J H Chen, Edwin Chapman, Edward J Modestino, Bruce Steinberg, Rajendra D Badgaiyan
The interaction of neurotransmitters and genes that control the release of dopamine is the Brain Reward Cascade (BRC). Variations within the BRC, whether genetic or epigenetic, may predispose individuals to addictive behaviors and altered pain tolerance. This discussion authored by a group of concerned scientists and clinicians examines the Genetic Addiction Risk Score (GARS), the first test to accurately predict vulnerability to pain, addiction, and other compulsive behaviors, defined as Reward Deficiency Syndrome (RDS)...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28929914/the-conundrum-of-opioid-tapering-in-long-term-opioid-therapy-for-chronic-pain-a-commentary
#18
Ajay Manhapra, Albert A Arias, Jane C Ballantyne
BACKGROUND: In response to the opioid epidemic and new guidelines, many patients on high-dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a unique clinical challenge is emerging: while many on LTOT have poor pain control, functional decline, psychiatric instability, aberrancies and misuse, these issues may often worsen with opioid tapering. Currently, a clear explanation and practical guidance on how to manage this perplexing clinical scenario is lacking...
September 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28922061/alanine-aminotransferase-and-total-bilirubin-are-synergistically-associated-with-metabolic-syndrome-among-middle-aged-and-elderly-japanese-women
#19
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
BACKGROUND: Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Alanine aminotransferase (ALT) at high levels and total bilirubin (T-BiL) at low levels were oxidative potentials, but it was uncertain whether ALT and T-BiL had an additive interaction for the risk of MetS. METHODS: From a single community, we recruited 864 women (70 ± 8 years) during their annual health examination. We cross-sectionally investigated whether ALT and T-BiL are associated with MetS and its components based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report...
October 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28918267/compulsivity-in-opioid-dependence
#20
Serenella Tolomeo, Keith Matthews, Douglas Steele, Alex Baldacchino
OBJECTIVE: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence. METHOD: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n=24), ii) heroin users stabilised on methadone maintenance treatment (n=48), iii) abstinent participants with a history of opioid dependence due to heroin use (n=24) and iv) healthy controls (n=50)...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
keyword
keyword
71189
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"