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BDNF DRD2 Interaction

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https://www.readbyqxmd.com/read/27228124/genetic-polymorphisms-and-the-adequacy-of-brain-stimulation-state-of-the-art
#1
Amene Saghazadeh, Shadi A Esfahani, Nima Rezaei
INTRODUCTION: Heterogeneity of therapeutic response to brain stimulation techniques has inspired scientists to uncover the secrets to success or failure of these projects. Genetic polymorphisms are one of the major causes of this heterogeneity. AREAS COVERED: More than twenty genetic variants within more than ten genes (e.g. BDNF, COMT, DRD2, TRPV1, 5-HT1A, 5-HHT, P2RX7, VEGF, TPH1, TPH2, ACE, APOE, GNB3, NET, NMDA receptors, and RGS4) have been investigated, among which the BDNF gene and its polymorphism, Val66Met, is the best documented variant...
September 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/26926580/interactive-effects-of-age-and-multi-gene-profile-on-motor-learning-and-sensorimotor-adaptation
#2
Fatemeh Noohi, Nate B Boyden, Youngbin Kwak, Jennifer Humfleet, Martijn L T M Müller, Nicolaas I Bohnen, Rachael D Seidler
The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes...
April 2016: Neuropsychologia
https://www.readbyqxmd.com/read/25778907/the-dyx2-locus-and-neurochemical-signaling-genes-contribute-to-speech-sound-disorder-and-related-neurocognitive-domains
#3
J D Eicher, C M Stein, F Deng, A A Ciesla, N R Powers, R Boada, S D Smith, B F Pennington, S K Iyengar, B A Lewis, J R Gruen
A major milestone of child development is the acquisition and use of speech and language. Communication disorders, including speech sound disorder (SSD), can impair a child's academic, social and behavioral development. Speech sound disorder is a complex, polygenic trait with a substantial genetic component. However, specific genes that contribute to SSD remain largely unknown. To identify associated genes, we assessed the association of the DYX2 dyslexia risk locus and markers in neurochemical signaling genes (e...
April 2015: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/25148110/effects-of-comt-drd2-bdnf-and-apoe-genotypic-variation-on-treatment-efficacy-and-cognitive-side-effects-of-electroconvulsive-therapy
#4
Chad A Bousman, Natalie Katalinic, Donel M Martin, Deidre J Smith, Anna Ingram, Nathan Dowling, Chee Ng, Colleen K Loo
OBJECTIVES: The aim of this study was to explore the main and interaction effects of the COMT Val158Met, DRD2 C957T, BDNF Val66Met, and APOE polymorphisms on treatment efficacy and cognitive side effects of electroconvulsive therapy (ECT). METHODS: A total of 117 adult inpatients with a diagnosis of major depressive disorder recruited from 3 hospitals were administered the Montgomery-Äsberg Depression Rating Scale and a cognitive battery assessing global cognition, anterograde memory, executive function, speed and concentration, as well as retrograde memory at baseline and after ECT treatment...
June 2015: Journal of ECT
https://www.readbyqxmd.com/read/24819687/genetic-heterogeneity-in-adolescents-depressive-symptoms-in-response-to-victimization
#5
Nisha C Gottfredson, Vangie A Foshee, Susan T Ennett, Brett Haberstick, Andrew Smolen
This study had two objectives: first, to determine the degree to which experiences of victimization by peers during adolescence led to a subsequent rise in depressive symptoms, and second, to identify genetic markers that predict depressive reactivity to victimization. We used a cohort sequential design to obtain a longitudinal sample of 1,475 adolescents (3,263 observations) in Grades 8 to 12 (56% female; 47% Black, 46% White). Multilevel growth curve models were used to assess whether victimization predicted depressive symptoms 6 months later, beyond baseline trajectories for depressive symptoms...
2015: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/24704148/chronic-lsd-alters-gene-expression-profiles-in-the-mpfc-relevant-to-schizophrenia
#6
David A Martin, Danuta Marona-Lewicka, David E Nichols, Charles D Nichols
Chronic administration of lysergic acid diethylamide (LSD) every other day to rats results in a variety of abnormal behaviors. These build over the 90 day course of treatment and can persist at full strength for at least several months after cessation of treatment. The behaviors are consistent with those observed in animal models of schizophrenia and include hyperactivity, reduced sucrose-preference, and decreased social interaction. In order to elucidate molecular changes that underlie these aberrant behaviors, we chronically treated rats with LSD and performed RNA-sequencing on the medial prefrontal cortex (mPFC), an area highly associated with both the actions of LSD and the pathophysiology of schizophrenia and other psychiatric illnesses...
August 2014: Neuropharmacology
https://www.readbyqxmd.com/read/24001007/polymorphisms-in-the-dopamine-receptor-2-gene-region-influence-improvements-during-working-memory-training-in-children-and-adolescents
#7
Stina Söderqvist, Hans Matsson, Myriam Peyrard-Janvid, Juha Kere, Torkel Klingberg
Studying the effects of cognitive training can lead to finding better treatments, but it can also be a tool for investigating factors important for brain plasticity and acquisition of cognitive skills. In this study, we investigated how single-nucleotide polymorphisms (SNPs) and ratings of intrinsic motivation were associated to interindividual differences in improvement during working memory training. The study included 256 children aged 7-19 years who were genotyped for 13 SNPs within or near eight candidate genes previously implicated in learning: COMT, SLC6A3 (DAT1), DRD4, DRD2, PPP1R1B (DARPP32), MAOA, LMX1A, and BDNF...
January 2014: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/23327578/pharmacogenetics-of-clinical-response-to-risperidone
#8
REVIEW
Adrián Llerena, Roland Berecz, Eva Peñas-Lledó, Agnes Süveges, Humberto Fariñas
Despite risperidone's proven safety and efficacy, existing pharmacogenetic knowledge could be applied to improve its clinical use. The present work aims to summarize the information about genetic polymorphisms affecting risperidone adverse reactions and efficacy during routine clinical practice. The most relevant genes involved in the metabolism of the drug (i.e., CYP2D6, CYP3A and ABCB1) appear to have the greatest potential to predict differences in plasma concentrations of the drug and its interactions, but also relate to side effects, such as neuroleptic syndrome, weight gain or polydipsia...
January 2013: Pharmacogenomics
https://www.readbyqxmd.com/read/23318717/sex-specific-effects-of-weight-affecting-gene-variants-in-a-life-course-perspective-the-hunt-study-norway
#9
K Kvaløy, B Kulle, P Romundstad, T L Holmen
OBJECTIVE: The impact of previously identified genetic variants directly or indirectly associated with obesity, were investigated at birth, adolescence and adulthood to provide knowledge concerning timing and mechanisms of obesity susceptibility with focus on sex differences. DESIGN: Twenty four previously identified obesity- and eating disorder susceptibility loci were tested for association with adiposity traits at birth (ponderal index (PI)), adolescence and young adulthood (body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR)) in 1782 individuals from the HUNT study...
September 2013: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/23103549/bdnf-val66met-and-drd2-taq1a-polymorphisms-interact-to-influence-ptsd-symptom-severity-a-preliminary-investigation-in-a-south-african-population
#10
Sian M J Hemmings, Lindi I Martin, Marisa Klopper, Lize van der Merwe, Lisa Aitken, Erika de Wit, Gillian F Black, Eileen G Hoal, Gerhard Walzl, Soraya Seedat
BACKGROUND: We evaluated the role that selected variants in serotonin transporter (5-HTT), dopamine receptor 2 (DRD2) and brain-derived neurotrophic factor (BDNF) genes play in PTSD symptom severity in an at-risk population. We also investigated the interaction between the genetic variants to determine whether these variables and the interactions between the variables influenced the severity of PTSD symptoms. METHODS: PTSD symptoms were quantitatively assessed using the Davidson Trauma Scale (DTS) in 150 participants from an at-risk South African population...
January 10, 2013: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/22615781/candidate-gene-based-association-study-of-antipsychotic-induced-movement-disorders-in-long-stay-psychiatric-patients-a-prospective-study
#11
P Roberto Bakker, Egbert Bakker, Najaf Amin, Cornelia M van Duijn, Jim van Os, Peter N van Harten
OBJECTIVE: Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2). METHODS: Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1...
2012: PloS One
https://www.readbyqxmd.com/read/22514151/the-interaction-between-bdnf-and-drd2-in-bipolar-ii-disorder-but-not-in-bipolar-i-disorder
#12
Chih-Chun Huang, Yun-Hsuan Chang, Sheng-Yu Lee, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru-Band Lu
Bipolar I (BP-I) and bipolar II (BP-II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP-I and BP-II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain-derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder...
July 2012: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/22507762/psychotropic-drug-effects-on-gene-transcriptomics-relevant-to-parkinson-s-disease
#13
REVIEW
Edward C Lauterbach
OBJECTIVES: Psychotropic drugs are widely prescribed in Parkinson's disease (PD) without regard to their pathobiological effects, and these drugs affect the transcription of a large number of genes. Effects of these drugs on PD risk gene transcription were therefore surveyed. METHODS: Results summarize a comprehensive survey of psychotropic effects on messenger ribonucleic acid (mRNA) expression evident in published data for 70 genes linked to PD risk. RESULTS: Psychotropic drugs can meaningfully affect PD risk gene mRNA transcription, including antipsychotics (upregulate dopamine receptors D2 and D3 (DRD2, DRD3); downregulate low-density lipoprotein receptor-related protein 8 (LRP8), ubiquitin carboxyl-terminal esterase L1 (UCHL1, also known as PARK5)), haloperidol (upregulates DRD3, parkin (PRKN, also known as PARK2), DRD2; downregulates brain-derived neurotrophic factor (BDNF)), risperidone (upregulates monoamine oxidase B (MAOB), DRD2), olanzapine (upregulates transmembrane protein 163 (TMEM163), BDNF, glutathione S-transferase mu 1 (GSTM1), MAOB, DRD2, solute carrier organic anion transporter family, member 3A1 (SLCO3A1)), aripiprazole (upregulates DRD2), quetiapine, paliperidone, lurasidone, carbamazepine, and many antidepressants (upregulate BDNF), lithium and bupropion (downregulate BDNF), amitriptyline (upregulates DRD3, DRD2), imipramine (upregulates BDNF, DRD3, DRD2), desipramine (upregulates BDNF, DRD3), and fluoxetine (upregulates acid beta-glucosidase (GBA), coiled-coil domain containing 62 (CCDC62), BDNF, DRD3, UCHL1, unc-13 homolog B (UNC13B), and perhaps huntingtin interacting protein 1 related (HIP1R); downregulates microtubule-associated protein tau (MAPT), methylcrotonoyl-coenzyme A carboxylase I (MCCC1), GSTM1, 28kDa calbindin 1 (CALB1))...
August 7, 2012: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/21261454/double-dissociation-of-dopamine-genes-and-timing-in-humans
#14
Martin Wiener, Falk W Lohoff, H Branch Coslett
A number of lines of evidence implicate dopamine in timing [Rammsayer, T. H. Neuropharmacological approaches to human timing. In S. Grondin (Ed.), Psychology of time (pp. 295-320). Bingley, UK: Emerald, 2008; Meck, W. H. Neuropharmacology of timing and time perception. Brain Research, Cognitive Brain Research, 3, 227-242, 1996]. Two human genetic polymorphisms are known to modulate dopaminergic activity. DRD2/ANKK1-Taq1a is a D(2) receptor polymorphism associated with decreased D(2) density in the striatum [Jönsson, E...
October 2011: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/21097659/interaction-effect-of-functional-variants-of-the-bdnf-and-drd2-ankk1-gene-is-associated-with-alexithymia-in-healthy-human-subjects
#15
COMPARATIVE STUDY
Nora T Walter, Christian Montag, Sebastian A Markett, Martin Reuter
OBJECTIVE: To test the hypothesis that the interaction between the brain-derived neurotrophic factor (BDNF) and dopamine receptor D(2) (DRD2)/ANKK1 gene contributes to individual differences in alexithymia. The personality construct of alexithymia refers to difficulties in emotional self-regulation and contributes as a risk factor to several mental disorders. Alexithymic individuals show an impoverished conscious experience of emotions but an intact autonomic emotional response. Persons with high alexithymia scores reportedly show a reduced activation of the anterior cingulate cortex (ACC) during the processing of emotional stimuli...
January 2011: Psychosomatic Medicine
https://www.readbyqxmd.com/read/19207030/genetic-susceptibility-to-schizophrenia-role-of-dopaminergic-pathway-gene-polymorphisms
#16
Meenal Gupta, Chitra Chauhan, Pallav Bhatnagar, Simone Gupta, Sandeep Grover, Prashant K Singh, Meera Purushottam, Odity Mukherjee, Sanjeev Jain, Samir K Brahmachari, Ritushree Kukreti
AIM: We investigated 16 polymorphisms from three genes, dopamine receptor D2 (DRD2), catechol-O-methyl transferase (COMT) and brain derived neurotrophic factor (BDNF), which are involved in the dopaminergic pathways, and have been reported to be associated with susceptibility to schizophrenia and response to antipsychotic therapy. MATERIALS & METHODS: Single-locus association analyses of these polymorphisms were carried out in 254 patients with schizophrenia and 225 controls, all of southern Indian origin...
February 2009: Pharmacogenomics
https://www.readbyqxmd.com/read/17126903/the-genetic-background-to-ptsd
#17
REVIEW
B F P Broekman, M Olff, F Boer
Although extensive research has already been done on the genetic bases of psychiatric disorders, little is known about polygenetic influences in posttraumatic stress disorder (PTSD). This article reviews molecular genetic studies relating to PTSD that were found in a literature search in Medline, Embase and Web of Science. Association studies have investigated 8 major genotypes in connection with PTSD. They have tested hypotheses involving key candidate genes in the serotonin (5-HTT), dopamine (DRD2, DAT), glucocorticoid (GR), GABA (GABRB), apolipoprotein systems (APOE2), brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY)...
2007: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/15952869/genetics-and-epigenetics-in-major-psychiatric-disorders-dilemmas-achievements-applications-and-future-scope
#18
REVIEW
Hamid M Abdolmaleky, Sam Thiagalingam, Marsha Wilcox
No specific gene has been identified for any major psychiatric disorder, including schizophrenia, in spite of strong evidence supporting a genetic basis for these complex and devastating disorders. There are several likely reasons for this failure, ranging from poor study design with low statistical power to genetic mechanisms such as polygenic inheritance, epigenetic interactions, and pleiotropy. Most study designs currently in use are inadequate to uncover these mechanisms. However, to date, genetic studies have provided some valuable insight into the causes and potential therapies for psychiatric disorders...
2005: American Journal of Pharmacogenomics: Genomics-related Research in Drug Development and Clinical Practice
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