keyword
https://read.qxmd.com/read/38176157/interactions-between-tdcs-treatment-and-comt-val158met-in-poststroke-cognitive-impairment
#1
JOURNAL ARTICLE
Yinan Ai, Yuanwen Liu, Mingyu Yin, Liying Zhang, Jing Luo, Shuxian Zhang, Li Huang, Chanjuan Zhang, Guirong Liu, Jie Fang, Haiqing Zheng, Lili Li, Xiquan Hu
OBJECTIVE: This study aimed to explore the effect of catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met to post-stroke cognitive impairment (PSCI) and the interaction with transcranial direct current stimulation (tDCS). METHODS: Seventy-six patients with PSCI were randomly assigned to Group (1) (n = 38) to receive anodal tDCS of left dorsolateral prefrontal cortex or Group (2) (n = 38) to receive sham stimulation...
December 27, 2023: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/37754245/dna-methylation-patterns-in-relation-to-acute-severity-and-duration-of-anxiety-and-depression
#2
JOURNAL ARTICLE
Eva Vidovič, Sebastian Pelikan, Marija Atanasova, Katarina Kouter, Indre Pileckyte, Aleš Oblak, Brigita Novak Šarotar, Alja Videtič Paska, Jurij Bon
Depression and anxiety are common mental disorders that often occur together. Stress is an important risk factor for both disorders, affecting pathophysiological processes through epigenetic changes that mediate gene-environment interactions. In this study, we explored two proposed models about the dynamic nature of DNA methylation in anxiety and depression: a stable change, in which DNA methylation accumulates over time as a function of the duration of clinical symptoms of anxiety and depression, or a flexible change, in which DNA methylation correlates with the acute severity of clinical symptoms...
September 6, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37636335/comt-val158met-and-bdnf-val66met-single-nucleotide-polymorphisms-are-not-associated-with-emotional-distress-one-year-after-moderate-severe-traumatic-brain-injury
#3
JOURNAL ARTICLE
Chloe Anderson, Amelia J Hicks, Jai Carmichael, Richard Burke, Jennie Ponsford
Emotional distress is a common, but poorly addressed, feature of moderate-severe traumatic brain injury (TBI). Previously identified sociodemographic, psychological, and injury-related factors account for only a small proportion of the variability in emotional distress post-TBI. Genetic factors may help to further understand emotional distress in this population. The catechol- O -methyltransferase (COMT) Val158 and brain-derived neurotrophic factor (BDNF) 66Met single-nucleotide polymorphisms (SNPs) have been identified as possible contributory factors to outcomes after TBI...
2023: Neurotrauma reports
https://read.qxmd.com/read/37589055/gene-exercise-interaction-on-brain-health-in-children-with-overweight-obesity-the-activebrains-randomized-controlled-trial
#4
JOURNAL ARTICLE
Abel Plaza-Florido, Irene Esteban-Cornejo, Jose Mora-Gonzalez, Lucia V Torres-Lopez, Francisco J Osuna-Prieto, Jose J Gil-Cosano, Shlomit Radom-Aizik, Idoia Labayen, Jonatan R Ruiz, Signe Altmäe, Francisco B Ortega
We investigated the interaction between a genetic score and an exercise intervention on brain health in children with overweight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 years, 59% girls) were randomized into a 20-week combined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms (rs6265 [ BDNF ], rs2253206 [ CREB1 ], rs2289656 [ NTRK2 ], rs4680 [ COMT ], rs429358, and rs7412 [ APOE ]) were genotyped...
August 17, 2023: Journal of Applied Physiology
https://read.qxmd.com/read/37390623/relationship-between-gene-environment-interaction-and-obsessive-compulsive-disorder-a-systematic-review
#5
REVIEW
Lina Wang, Yu Chen, Miao Wang, Chaoben Zhao, Dongdong Qiao
BACKGROUND: Gene-environment interaction (G × E) refers to the change of genetic effects under the participation of environmental factors resulting in differences in genetic expression. G × E has been studied in the occurrence and development of many neuropsychiatric disorders, including obsessive-compulsive disorder (OCD). AIM: A systematic review was conducted to investigate the role of G × E plays in OCD. This review explored the relationship between G × E and the susceptibility to OCD occurrence, disease progression, and treatment response...
August 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37159618/a-review-of-biomarkers-in-delirium-superimposed-on-dementia-dsd-and-their-clinical-application-to-personalized-treatment-and-management
#6
REVIEW
Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafshah
Delirium superimposed on dementia (DSD) occurs when patients with pre-existing dementia develop delirium. This complication causes patients to become impaired, posing safety concerns for both hospital staff and patients. Furthermore, there is an increased risk of worsening functional disability and death. Despite medical advances, DSD provides both diagnostic and therapeutic challenges to providers. Identifying at-risk patients and providing personalized medicine and patient care can decrease disease burden in a time-efficient manner...
May 2023: Curēus
https://read.qxmd.com/read/36873203/the-pharmacogenetics-of-the-new-generation-antipsychotics-a-scoping-review-focused-on-patients-with-severe-psychiatric-disorders
#7
REVIEW
Octavian Vasiliu
Exploring the possible correlations between gene variations and the clinical effects of the new-generation antipsychotics is considered essential in the framework of personalized medicine. It is expected that pharmacogenetic data will be useful for increasing the treatment efficacy, tolerability, therapeutic adherence, functional recovery, and quality of life in patients with severe psychiatric disorders (SPD). This scoping review investigated the available evidence about the pharmacokinetics, pharmacodynamics, and pharmacogenetics of five new-generation antipsychotics, i...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/36519153/intellectual-enrichment-and-genetic-modifiers-of-cognition-and-brain-volume-in-huntington-s-disease
#8
JOURNAL ARTICLE
Marina Papoutsi, Michael Flower, Davina J Hensman Moss, Peter Holmans, Carlos Estevez-Fraga, Eileanoir B Johnson, Rachael I Scahill, Geraint Rees, Douglas Langbehn, Sarah J Tabrizi
An important step towards the development of treatments for cognitive impairment in ageing and neurodegenerative diseases is to identify genetic and environmental modifiers of cognitive function and understand the mechanism by which they exert an effect. In Huntington's disease, the most common autosomal dominant dementia, a small number of studies have identified intellectual enrichment, i.e. a cognitively stimulating lifestyle and genetic polymorphisms as potential modifiers of cognitive function. The aim of our study was to further investigate the relationship and interaction between genetic factors and intellectual enrichment on cognitive function and brain atrophy in Huntington's disease...
2022: Brain communications
https://read.qxmd.com/read/35405173/the-association-between-overnight-recognition-accuracy-and-slow-oscillation-spindle-coupling-is-moderated-by-bdnf-val66met
#9
JOURNAL ARTICLE
Risto Halonen, Liisa Kuula, Jari Lahti, Katri Räikkönen, Anu-Katriina Pesonen
During sleep, memories are consolidated via oscillatory events that occur in temporal and phasic synchrony. Several studies show that sleep spindles peaking close to the depolarized positive peaks of slow oscillations (SO) associate with better retention of memories. The exact timing of this synchrony presumably depends on the properties of the related neural network that, in turn, is affected by certain genetic variants associated with brain development and function. Brain-derived neurotrophic factor (BDNF) Val66Met and Catechol-O-methyltransferase (COMT) Val158Met are repeatedly reported to implicate the structure and function of prefrontal and hippocampal areas as well as molecular events promoting synaptic plasticity...
June 25, 2022: Behavioural Brain Research
https://read.qxmd.com/read/35328036/the-influence-of-5-httlpr-bdnf-rs6265-and-comt-rs4680-polymorphisms-on-impulsivity-in-bipolar-disorder-the-role-of-gender
#10
JOURNAL ARTICLE
Andrea Boscutti, Alessandro Pigoni, Giuseppe Delvecchio, Matteo Lazzaretti, Gian Mario Mandolini, Paolo Girardi, Adele Ferro, Michela Sala, Vera Abbiati, Marco Cappucciati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Matteo Balestrieri, Giuseppe Damante, Carolina Bonivento, Roberta Rossi, Livio Finos, Alessandro Serretti, Paolo Brambilla, The Gecobip Group
Impulsivity has been proposed as an endophenotype for bipolar disorder (BD); moreover, impulsivity levels have been shown to carry prognostic significance and to be quality-of-life predictors. To date, reports about the genetic determinants of impulsivity in mood disorders are limited, with no studies on BD individuals. Individuals with BD and healthy controls (HC) were recruited in the context of an observational, multisite study (GECOBIP). Subjects were genotyped for three candidate single-nucleotide polymorphisms (SNPs) (5-HTTLPR, COMT rs4680, BDNF rs6265); impulsivity was measured through the Italian version of the Barratt Impulsiveness Scale (BIS-11)...
March 9, 2022: Genes
https://read.qxmd.com/read/34827409/associations-of-immune-genetic-variability-with-gulf-war-illness-in-1990-1991-gulf-war-veterans-from-the-gulf-war-illness-consortium-gwic-multisite-case-control-study
#11
JOURNAL ARTICLE
Janet K Coller, Jonathan Tuke, Taylor J Wain, Emily Quinn, Lea Steele, Maria Abreu, Kristina Aenlle, Nancy Klimas, Kimberly Sullivan
Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility. Given the impact of immune responses linked to GWI symptomology, genetic variability that causes persistent inflammatory/immune alterations may be key. This Boston University-based Gulf War Illness Consortium (GWIC) study investigated the impact of single nucleotide polymorphisms (SNPs) in variants of immune and pain genetic markers IL1B , IL2 , IL6 , IL6R , IL10 , TNF , TGF , TLR2 , TLR4 , MD2 , MYD88 , BDNF , CRP , ICE, COMT and OPRM1 on GWI occurrence in a Caucasian subset of Gulf War (GW) veterans with (cases, n = 170) and without (controls, n = 34) GWI...
October 26, 2021: Brain Sciences
https://read.qxmd.com/read/34668150/revelation-of-pivotal-genes-pertinent-to-alzheimer-s-pathogenesis-a-methodical-evaluation-of-32-geo-datasets
#12
JOURNAL ARTICLE
Hema Sree Gns, Saraswathy Ganesan Rajalekshmi, Raghunadha R Burri
Alzheimer's disease (AD), a dreadful neurodegenerative disorder that affects cognitive and behavioral function in geriatric populations, is characterized by the presence of amyloid deposits and neurofibrillary tangles in brain regions. The International D World Alzheimer Report 2018 noted a global prevalence of 50 million AD cases and forecasted a threefold rise to 139 million by 2050. Although there exist numerous genetic association studies pertinent to AD in different ethnicities, critical genetic factors and signaling pathways underlying its pathogenesis remain ambiguous...
February 2022: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/34566593/prenatal-maternal-stress-from-a-natural-disaster-and-hippocampal-volumes-gene-by-environment-interactions-in-young-adolescents-from-project-ice-storm
#13
JOURNAL ARTICLE
Lei Cao-Lei, Sandra Yogendran, Romane Dufoix, Guillaume Elgbeili, David P Laplante, Suzanne King
Gene-by-environment interactions influence brain development from conception to adulthood. In particular, the prenatal period is a window of vulnerability for the interplay between environmental and genetic factors to influence brain development. Rodent and human research demonstrates that prenatal maternal stress (PNMS) alters hippocampal volumes. Although PNMS affects hippocampal size on average, similar degrees of PNMS lead to different effects in different individuals. This differential susceptibility to the effects of PNMS may be due to genetic variants...
2021: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/34413728/the-interplay-between-prenatal-adversity-offspring-dopaminergic-genes-and-early-parenting-on-toddler-attentional-function
#14
JOURNAL ARTICLE
Eszter Szekely, Alexia Jolicoeur-Martineau, Leslie Atkinson, Robert D Levitan, Meir Steiner, John E Lydon, Alison S Fleming, James L Kennedy, Ashley Wazana
Background : Few studies have explored the complex gene-by-prenatal environment-by-early postnatal environment interactions that underlie the development of attentional competence. Here, we examined if variation in dopamine-related genes interacts with prenatal adversity to influence toddler attentional competence and whether this influence is buffered by early positive maternal behavior. Methods : From the Maternal Adversity, Vulnerability and Neurodevelopment cohort, 134 participants (197 when imputing missing data) had information on prenatal adversity (prenatal stressful life events, prenatal maternal depressive symptoms, and birth weight), five dopamine-related genes ( DAT1, DRD4, DRD2, COMT, BDNF ), observed maternal parenting behavior at 6 months and parent-rated toddler attentional competence at 18 and 24 months...
2021: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/34392471/cognitive-impairment-and-associations-with-structural-brain-networks-endocrine-status-and-risk-genotypes-in-newly-orchiectomized-testicular-cancer-patients
#15
JOURNAL ARTICLE
Cecilie R Buskbjerg, Robert Zachariae, Mads Agerbæk, Claus H Gravholt, Lene Haldbo-Classen, S M Hadi Hosseini, Ali Amidi
A higher incidence of cognitive impairment (CI) has previously been reported among orchiectomized testicular cancer patients (TCPs), but little is known about the underlying pathophysiology. The present study assessed CI in newly orchiectomized TCPs and explored the structural brain networks, endocrine status, and selected genotypes. Forty TCPs and 22 healthy controls (HCs) underwent neuropsychological testing and magnetic resonance imaging, and provided a blood sample. CI was defined as a z-score ≤ -2 on one neuropsychological test or ≤ -1...
February 2022: Brain Imaging and Behavior
https://read.qxmd.com/read/34127140/use-of-a-consultation-service-following-pharmacogenomic-testing-in-psychiatry
#16
JOURNAL ARTICLE
Daniel Dowd, David S Krause
BACKGROUND: There is a plethora of drugs available to psychiatrists for treatment of mental illness, which can vary in efficacy, tolerability, metabolic pathways and drug-drug interactions. Psychotropics are the second most commonly listed therapeutic class mentioned in the FDA's Table of Pharmacogenomic Biomarkers in Drug Labeling. Pharmacogenomic (PGx) assays are increasingly used in psychiatry to help select safe and appropriate medication for a variety of mental illnesses. Our commercial laboratory offers PGx expert consultations by PharmDs and PhDs to clinician-users...
April 2021: CNS Spectrums
https://read.qxmd.com/read/34068064/cognitive-impairment-in-parkinson-s-disease-epidemiology-clinical-profile-protective-and-risk-factors
#17
REVIEW
Paulina Gonzalez-Latapi, Ece Bayram, Irene Litvan, Connie Marras
Cognitive impairment is a common non-motor symptom in Parkinson's Disease (PD) and an important source of patient disability and caregiver burden. The timing, profile and rate of cognitive decline varies widely among individuals with PD and can range from normal cognition to mild cognitive impairment (PD-MCI) and dementia (PDD). Beta-amyloid and tau brain accumulation, oxidative stress and neuroinflammation are reported risk factors for cognitive impairment. Traumatic brain injury and pesticide and tobacco exposure have also been described...
May 13, 2021: Behavioral Sciences
https://read.qxmd.com/read/33876571/sex-effects-for-the-interaction-of-dopamine-related-genetic-variants-for-comt-and-bdnf-on-declarative-memory-performance
#18
JOURNAL ARTICLE
Sandra Van der Auwera, Jan Terock, Alexander Teumer, Georg Schomerus, Georg Homuth, Hans J Grabe
Genetic factors are assumed to contribute to memory performance, especially genes affecting the dopaminergic neurotransmission. We aimed to evaluate leading functional genetic variants of the dopamine system, Catechol-O-methyltransferase (COMT) SNP rs4680 and Brain-derived neurotropic factor (BDNF) SNP rs6265, previously found to be associated with memory performance. In two independent general population cohorts (total N = 5937) we investigated direct and interaction effects between COMT and BDNF SNPs on declarative memory performance...
June 2021: Genes, Brain, and Behavior
https://read.qxmd.com/read/33673282/the-interaction-of-selective-a1-and-a2a-adenosine-receptor-antagonists-with-magnesium-and-zinc-ions-in-mice-behavioural-biochemical-and-molecular-studies
#19
JOURNAL ARTICLE
Aleksandra Szopa, Karolina Bogatko, Mariola Herbet, Anna Serefko, Marta Ostrowska, Sylwia Wośko, Katarzyna Świąder, Bernadeta Szewczyk, Aleksandra Wlaź, Piotr Skałecki, Andrzej Wróbel, Sławomir Mandziuk, Aleksandra Pochodyła, Anna Kudela, Jarosław Dudka, Maria Radziwoń-Zaleska, Piotr Wlaź, Ewa Poleszak
The purpose of the study was to investigate whether the co-administration of Mg2+ and Zn2+ with selective A1 and A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, and spontaneous locomotor motility tests in mice were performed. Further, biochemical and molecular studies were conducted. The obtained results indicate the interaction of DPCPX and istradefylline with Mg2+ and Zn2+ manifested in an antidepressant-like effect. The reduction of the BDNF serum level after co-administration of DPCPX and istradefylline with Mg2+ and Zn2+ was noted...
February 12, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/32899127/effects-of-childhood-adversity-and-its-interaction-with-the-maoa-bdnf-and-comt-polymorphisms-on-subclinical-attention-deficit-hyperactivity-symptoms-in-generally-healthy-youth
#20
JOURNAL ARTICLE
Meng-Che Tsai, Kai-Jyun Jhang, Chih-Ting Lee, Yu-Fang Lin, Carol Strong, Yi-Ching Lin, Yi-Ping Hsieh, Chung-Ying Lin
We aimed to investigate the effects of childhood adversity and its interaction with the polymorphisms in the monoamine oxidase A (MAOA), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) genes on attention and hyperactivity disorder (ADHD) symptoms in a community sample of generally healthy youth. Participants (N = 432) completed questionnaires assessing ADHD symptoms (i.e., inattention, hyperactivity, and impulsiveness) and adverse childhood experiences, such as adverse environments (AEs) and childhood maltreatment (CM)...
September 3, 2020: Children
keyword
keyword
71183
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.