Andrea Boscutti, Alessandro Pigoni, Giuseppe Delvecchio, Matteo Lazzaretti, Gian Mario Mandolini, Paolo Girardi, Adele Ferro, Michela Sala, Vera Abbiati, Marco Cappucciati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Matteo Balestrieri, Giuseppe Damante, Carolina Bonivento, Roberta Rossi, Livio Finos, Alessandro Serretti, Paolo Brambilla, The Gecobip Group
Impulsivity has been proposed as an endophenotype for bipolar disorder (BD); moreover, impulsivity levels have been shown to carry prognostic significance and to be quality-of-life predictors. To date, reports about the genetic determinants of impulsivity in mood disorders are limited, with no studies on BD individuals. Individuals with BD and healthy controls (HC) were recruited in the context of an observational, multisite study (GECOBIP). Subjects were genotyped for three candidate single-nucleotide polymorphisms (SNPs) (5-HTTLPR, COMT rs4680, BDNF rs6265); impulsivity was measured through the Italian version of the Barratt Impulsiveness Scale (BIS-11)...
March 9, 2022: Genes