keyword
MENU ▼
Read by QxMD icon Read
search

COMT BDNF Interaction

keyword
https://www.readbyqxmd.com/read/29093492/the-association-between-gene-variants-and-longitudinal-structural-brain-changes-in-psychosis-a-systematic-review-of-longitudinal-neuroimaging-genetics-studies
#1
REVIEW
Julia H Harari, Covadonga M Díaz-Caneja, Joost Janssen, Kenia Martínez, Bárbara Arias, Celso Arango
Evidence suggests that genetic variation might influence structural brain alterations in psychotic disorders. Longitudinal genetic neuroimaging (G-NI) studies are designed to assess the association between genetic variants, disease progression and brain changes. There is a paucity of reviews of longitudinal G-NI studies in psychotic disorders. A systematic search of PubMed from inception until November 2016 was conducted to identify longitudinal G-NI studies examining the link between Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI)-based brain measurements and specific gene variants (SNPs, microsatellites, haplotypes) in patients with psychosis...
November 1, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29056292/epigenetics-and-gene-expression-profile-in-first-episode-psychosis-the-role-of-childhood-trauma
#2
REVIEW
Simona Tomassi, Sarah Tosato
Childhood Trauma (CT) mediation of the epigenome and its impact on gene expression profile could provide a mechanism for the gene-environment interaction underling psychosis. We reviewed the evidence concerning epigenetic and gene expression modifications associated with CT in both First-Episode Psychosis (FEP) and healthy subjects. In order to explore the relative role of psychosis itself in determining these modifications, evidence about FEP and epigenetics/gene expression was also summarized. We performed a systematic search on PubMed, last updated in December 2016...
October 19, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29044248/task-demands-tdcs-intensity-and-the-comt-val-158-met-polymorphism-impact-tdcs-linked-working-memory-training-gains
#3
Jaclyn A Stephens, Kevin T Jones, Marian E Berryhill
Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BDNF val(66)met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902619/a-case-control-association-study-of-12-candidate-genes-and-attempted-suicide-in-french-adolescents
#4
Bojan Mirkovic, David Cohen, Claudine Laurent, Malaika Lasfar, Christophe Marguet, Prsicille Gerardin
Background Suicide is the second leading cause of death for 10-19-year-olds. Evidence has shown that attempted suicide is a complex interplay of genes and environmental factors. In the adult population, possible associations between genetic polymorphisms and suicidal behaviors have been investigated for several genes, most often with inconsistent findings and poor replicability of significant associations. This study aimed to identify gene variants conferring risk for adolescent suicide attempt. Methods We selected the genes and variants after an analysis of the literature and a selection of the most significant associations identified...
September 13, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28867940/genetics-of-generalized-anxiety-disorder-and-related-traits
#5
Michael G Gottschalk, Katharina Domschke
This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenotypes based on family and twin studies. Recent advances of linkage studies, genome-wide association studies, and candidate gene studies (eg, 5-HTT, 5-HT1A, MAOA, BDNF) are outlined. Functional and structural neuroimaging and neurophysiological readouts relating to peripheral stress markers and psychophysiology are further integrated, building a multilevel disease framework...
June 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28865405/the-role-of-stress-regulation-genes-in-moderating-the-association-of-stress-and-daily-life-psychotic-experiences
#6
P Cristóbal-Narváez, T Sheinbaum, I Myin-Germeys, T R Kwapil, M de Castro-Catala, T Domínguez-Martínez, A Racioppi, M Monsonet, L Hinojosa-Marqués, R van Winkel, A Rosa, N Barrantes-Vidal
OBJECTIVE: The interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early-life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early-psychosis and non-clinical groups for these interactions. METHODS: Two hundred and forty-two non-clinical and 96 early-psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress...
October 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28830794/regulation-of-gene-transcription-in-bipolar-disorders-role-of-dna-methylation-in-the-relationship-between-prodynorphin-and-brain-derived-neurotrophic-factor
#7
Claudio D'Addario, Maria Carlotta Palazzo, Beatrice Benatti, Benedetta Grancini, Mariangela Pucci, Andrea Di Francesco, Giulia Camuri, Daniela Galimberti, Chiara Fenoglio, Elio Scarpini, A Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Osso
Bipolar Disorder (BD) is a prevalent and disabling condition, determined by gene-environment interactions, possibly mediated by epigenetic mechanisms. The present study aimed at investigating the transcriptional regulation of BD selected target genes by DNA methylation in peripheral blood mononuclear cells of patients with a DSM-5 diagnosis of type I (BD-I) and type II (BD-II) Bipolar Disorders (n=99), as well as of healthy controls (CT, n=42). The analysis of gene expression revealed prodynorphin (PDYN) mRNA levels significantly reduced in subjects with BD-II but not in those with BD-I, when compared to CT...
August 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28822116/interactions-between-variation-in-candidate-genes-and-environmental-factors-in-the-etiology-of-schizophrenia-and-bipolar-disorder-a-systematic-review
#8
REVIEW
Błażej Misiak, Filip Stramecki, Łukasz Gawęda, Katarzyna Prochwicz, Maria M Sąsiadek, Ahmed A Moustafa, Dorota Frydecka
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28590587/genetic-variants-in-5-httlpr-bdnf-htr1a-comt-and-fkbp5-and-risk-for-treated-depression-after-cancer-diagnosis
#9
Nis P Suppli, Jens D Bukh, Terrie E Moffitt, Avshalom Caspi, Christoffer Johansen, Anne Tjønneland, Lars V Kessing, Susanne O Dalton
BACKGROUND: The role of gene-environment interactions in the pathogenesis of depression is unclear. Previous studies addressed vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants; however, the importance of individual genetic variants, the environmental exposures with which they interact, and the magnitude of the risk conveyed by these interactions remain elusive. METHODS: We included 7,320 people with a first primary cancer identified in the prospective Diet, Cancer and Health study in an exposed-only cohort study...
June 7, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28142064/cannabis-use-comt-bdnf-and-age-at-first-episode-psychosis
#10
Anna Mané, Daniel Bergé, Maria Jose Penzol, Mara Parellada, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Iluminada Corripio, Bibiana Cabrera, Ana Maria Sánchez-Torres, Jerónimo Saiz-Ruiz, Miguel Bernardo, PEPs Group
Although an interaction between COMT Val158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these polymorphisms and early cannabis use and the age at the first episode of psychosis. The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28131014/executive-function-performance-and-change-in-aging-is-predicted-by-apolipoprotein-e-intensified-by-catechol-o-methyltransferase-and-brain-derived-neurotrophic-factor-and-moderated-by-age-and-lifestyle
#11
Shraddha Sapkota, Lars Bäckman, Roger A Dixon
Recent studies have reported several genetic, health, and aging interaction effects in predicting cognitive performance and change. We used an accelerated longitudinal design to examine interactions among genetic, lifestyle, and aging for executive function (EF) in non-demented older adults (n = 634; age range = 53-95 years). The polymorphisms were apolipoprotein E (APOE), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF). We tested (1) independent and additive effects of APOE, COMT, and BDNF and (2) APOE effect modification for COMT + BDNF, on EF performance and 9-year change as separated by age and lifestyle activities...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/27898499/comt-and-bdnf-gene-variants-help-to-predict-alcohol-consumption-in-alcohol-dependent-patients
#12
Anna Klimkiewicz, Anna Mach, Andrzej Jakubczyk, Jakub Klimkiewicz, Anna Wnorowska, Maciej Kopera, Sylwia Fudalej, Margit Burmeister, Kirk Brower, Marcin Wojnar
BACKGROUND: The neurobiology of alcohol dependence (AD) involves alterations in neurotransmitters and the stress response. We hypothesized that an interaction between functional variants of dopaminergic and neurotrophic genes may influence drinking in AD. METHODS: The relationship between alcohol consumption and single-nucleotide polymorphisms, Val66Met in the brain-derived neurotrophic factor (BDNF), and Val158Met in the catechol-O-methyltransferase (COMT), was analyzed among 281 alcohol-dependent individuals...
March 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27853425/interaction-effects-of-bdnf-and-comt-genes-on-resting-state-brain-activity-and-working-memory
#13
Wen Chen, Chunhui Chen, Mingrui Xia, Karen Wu, Chuansheng Chen, Qinghua He, Gui Xue, Wenjing Wang, Yong He, Qi Dong
Catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) genes have been found to interactively influence working memory (WM) as well as brain activation during WM tasks. However, whether the two genes have interactive effects on resting-state activities of the brain and whether these spontaneous activations correlate with WM are still unknown. This study included behavioral data from WM tasks and genetic data (COMT rs4680 and BDNF Val66Met) from 417 healthy Chinese adults and resting-state fMRI data from 298 of them...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27649267/ethnicity-dependent-influence-of-innate-immune-genetic-markers-on-morphine-pca-requirements-and-adverse-effects-in-postoperative-pain
#14
Andrew A Somogyi, Alex T Sia, Ene-Choo Tan, Janet K Coller, Mark R Hutchinson, Daniel T Barratt
Although several genetic factors have been associated with postsurgical morphine requirements, those involving the innate immune system and cytokines have not been well investigated. The aim of this study was to investigate the contribution of genetic variability in innate immune signalling pathways to variability in morphine dosage after elective caesarean section under spinal anaesthesia in 133 Indian, 230 Malay, and 598 Han Chinese women previously studied. Twenty single nucleotide polymorphisms in 14 genes involved in glial activation (TLR2, TLR4, MYD88, MD2), inflammatory signalling (IL2, IL6, IL10, IL1B, IL6R, TNFA, TGFB1, CRP, CASP1), and neuronal regulation (BDNF) were newly investigated, in addition to OPRM1, COMT, and ABCB1 genetic variability identified previously...
November 2016: Pain
https://www.readbyqxmd.com/read/27610078/maoa-influences-the-trajectory-of-attentional-development
#15
Rebecca A Lundwall, Claudia G Rasmussen
Attention is vital to success in all aspects of life (Meck and Benson, 2002; Erickson et al., 2015), hence it is important to identify biomarkers of later attentional problems early enough to intervene. Our objective was to determine if any of 11 genes (APOE, BDNF, HTR4, CHRNA4, COMT, DRD4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25) predicted the trajectory of attentional development within the same group of children between infancy and childhood. We recruited follow up participants from children who participated as infants in visual attention studies and used a similar task at both time points...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27228124/genetic-polymorphisms-and-the-adequacy-of-brain-stimulation-state-of-the-art
#16
REVIEW
Amene Saghazadeh, Shadi A Esfahani, Nima Rezaei
INTRODUCTION: Heterogeneity of therapeutic response to brain stimulation techniques has inspired scientists to uncover the secrets to success or failure of these projects. Genetic polymorphisms are one of the major causes of this heterogeneity. AREAS COVERED: More than twenty genetic variants within more than ten genes (e.g. BDNF, COMT, DRD2, TRPV1, 5-HT1A, 5-HHT, P2RX7, VEGF, TPH1, TPH2, ACE, APOE, GNB3, NET, NMDA receptors, and RGS4) have been investigated, among which the BDNF gene and its polymorphism, Val66Met, is the best documented variant...
September 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27047397/dna-methylation-at-the-neonatal-state-and-at-the-time-of-diagnosis-preliminary-support-for-an-association-with-the-estrogen-receptor-1-gamma-aminobutyric-acid-b-receptor-1-and-myelin-oligodendrocyte-glycoprotein-in-female-adolescent-patients-with-ocd
#17
Judith Becker Nissen, Christine Søholm Hansen, Anna Starnawska, Manuel Mattheisen, Anders Dupont Børglum, Henriette Nørmølle Buttenschøn, Mads Hollegaard
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Non-genetic factors and their interaction with genes have attracted increasing attention. Epigenetics is regarded an important interface between environmental signals and activation/repression of genomic responses. Epigenetic mechanisms have not previously been examined in OCD in children and adolescents. The aim of the present study was to examine the DNA methylation profile of selected genes in blood spots from neonates later diagnosed with OCD and in the same children/adolescents at the time of diagnosis compared with age- and sex-matched controls...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27004987/interaction-of-comt-rs4680-and-bdnf-rs6265-polymorphisms-on-functional-connectivity-density-of-the-left-frontal-eye-field-in-healthy-young-adults
#18
Wei Li, Bing Liu, Jiayuan Xu, Tianzi Jiang, Chunshui Yu
As modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional connectivity density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT × BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U-shape modulation by the presumed dopamine signaling...
July 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26926580/interactive-effects-of-age-and-multi-gene-profile-on-motor-learning-and-sensorimotor-adaptation
#19
Fatemeh Noohi, Nate B Boyden, Youngbin Kwak, Jennifer Humfleet, Martijn L T M Müller, Nicolaas I Bohnen, Rachael D Seidler
The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes...
April 2016: Neuropsychologia
https://www.readbyqxmd.com/read/26721949/glucocorticoid-receptors-brain-derived-neurotrophic-factor-serotonin-and-dopamine-neurotransmission-are-associated-with-interferon-induced-depression
#20
M Udina, R Navinés, E Egmond, G Oriolo, K Langohr, D Gimenez, M Valdés, E Gómez-Gil, I Grande, M Gratacós, F Kapczinski, F Artigas, E Vieta, R Solà, R Martín-Santos
BACKGROUND: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, proinflammatory cytokines change brain function in several ways, such as altering neurotransmitters, the glucocorticoid axis, and apoptotic mechanisms. This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with chronic hepatitis C...
April 2016: International Journal of Neuropsychopharmacology
keyword
keyword
71183
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"