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https://www.readbyqxmd.com/read/28750501/the-current-management-of-kidney-disease-in-the-elderly
#1
Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Magdalena Durlik
CKD, diabetes and cardiovascular disease constitute three interrelated conditions of strong public health relevance. Elderly individuals account for the largest and the most rapidly growing age segment of the ESRD population. The elderly are affected by the same types of kidney diseases as younger individuals, but aging itself is associated with a gradual reduction in eGFR, which leads to the diminishment of the functional reserve and makes an individual more vulnerable to injurious effects of hypertension, cardiovascular disease, diabetes, and drugs' toxicity...
July 27, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28750435/-cell-transplantation-in-age-related-macular-degeneration
#2
Bernd Kirchhof
Robert Machemer offers a surgical approach to age-related macular degeneration with his retinal rotation. There is already considerable experimental and clinical knowledge available in Europe and the US on transplantation techniques for age-related macular degeneration. On average, initial visual acuity can be preserved. When photodynamic therapy was standard for exudative AMD, transplantation was superior. Photodynamic therapy could not stop, but was instead able to slow down visual loss. Currently, VEGF-blocker therapy has priority, because the visual acuity can be improved...
July 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28750307/resilient-protein-co-expression-network-in-male-orbitofrontal-cortex-layer-2-3-during-human-aging
#3
Mohan Pabba, Enzo Scifo, Fenika Kapadia, Yuliya S Nikolova, Tianzhou Ma, Naguib Mechawar, George C Tseng, Etienne Sibille
The orbitofrontal cortex (OFC) is vulnerable to normal and pathologic aging. Currently, layer resolution large-scale proteomic studies describing "normal" age-related alterations at OFC are not available. Here, we performed a large-scale exploratory high-throughput mass spectrometry-based protein analysis on OFC layer 2/3 from 15 "young" (15-43 years) and 18 "old" (62-88 years) human male subjects. We detected 4193 proteins and identified 127 differentially expressed (DE) proteins (p-value ≤0.05; effect size >20%), including 65 up- and 62 downregulated proteins (e...
July 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28750224/second-hand-smoke-generated-by-combustion-and-electronic-smoking-devices-used-in-real-scenarios-ultrafine-particle-pollution-and-age-related-dose-assessment
#4
Carmela Protano, Maurizio Manigrasso, Pasquale Avino, Matteo Vitali
Aerosol measurements were carried out in a model room where both combustion (conventional and hand-rolled cigarettes, a cigar and tobacco pipe) and non-combustion (e-cigarette and IQOS®) devices were smoked. The data were used to estimate the dose of particles deposited in the respiratory systems of individuals from 3months to 21years of age using the multiple-path particle dosimetry (MPPD) model. Regardless of the smoking device, the highest doses were received by infants, which reached 9.88×10(8)particles/kg bw during a cigar smoking session...
July 24, 2017: Environment International
https://www.readbyqxmd.com/read/28750126/association-between-c-reactive-protein-and-age-related-macular-degeneration-les-liaisons-dangereuses
#5
Tiarnán D Keenan, Emily Y Chew
No abstract text is available yet for this article.
July 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28750115/association-of-c-reactive-protein-genetic-polymorphisms-with-late-age-related-macular-degeneration
#6
Valentina Cipriani, Ruth E Hogg, Reecha Sofat, Anthony T Moore, Andrew R Webster, John R W Yates, Astrid E Fletcher
Importance: C-reactive protein (CRP) is a circulating inflammatory marker associated with late age-related macular degeneration (AMD). It remains uncertain whether the association between CRP concentrations and AMD is causal. Objective: To assess whether CRP (OMIM 123260) single-nucleotide polymorphisms that influence circulating CRP concentrations are associated with late AMD. Design, Setting, and Participants: Participants in 2 UK, hospital-based, case-control studies (Cambridge AMD study and Moorfields Eye Hospital AMD study) and 1 pan-European, cross-sectional, population-based study (the European Eye [EUREYE] Study) were recruited between November 6, 2000, and April 30, 2007...
July 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28749919/philadelphia-chromosome-like-acute-lymphoblastic-leukemia-progress-in-a-new-cancer-subtype
#7
Julia Wells, Nitin Jain, Marina Konopleva
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a newly described, high-risk subtype of B-cell ALL. It is characterized by a gene expression profile similar to that of Ph-positive ALL; however, the BCR-ABL1 fusion is not present. The World Health Organization classification of myeloid neoplasms and acute leukemia recently was updated to include the Ph-like or BCR-ABL1-like ALL subtype of B-cell ALL as a provisional entity. Unlike Ph-positive ALL, which is characterized by the pathognomonic BCR-ABL1 fusion, Ph-like ALL is characterized by a multitude of different genetic rearrangements and mutations...
July 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28749635/awareness-of-breast-cancer-among-female-care-givers-in-tertiary-cancer-hospital-china
#8
Negalign Getahun Dinegde, Li Xuying
Objective: Breast cancer is a worldwide public health issue and most common cancer diagnosed among women including China, where advanced stages at diagnosis appears to be increasing and an ever-rising incidence twice as fast as global rates. The study was conducted to describe the awareness of breast cancer and associated factors among care giver women in tertiary Cancer Hospital, China. Methods: Institutional based cross-sectional study was conducted among 261 women selected by systematic random sampling. Information provided by the participants was converted into awareness scores for analysis using SPSS version 23...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748504/whole-brain-analyses-of-age-related-microstructural-changes-quantified-using-different-diffusional-magnetic-resonance-imaging-methods
#9
Miho Ota, Noriko Sato, Norihide Maikusa, Daichi Sone, Hiroshi Matsuda, Hiroshi Kunugi
PURPOSE: The new diffusional magnetic resonance imaging (dMRI) techniques, diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) have been developed to clarify the microstructural changes. To our knowledge, however, there is little information on the similarities and differences of these metrics evaluated by the image-by-image paired t test. MATERIALS AND METHODS: Twenty-three healthy subjects underwent dMRI. We estimated the relationships of these metrics evaluated by the image-by-image paired t-test and compared aging effects on each metric...
July 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28748039/age-related-prevalence-and-characteristics-of-aggregatibacter-actinomycetemcomitans-in-periodontitis-patients-living-in-sweden
#10
Rolf Claesson, Carola Höglund-Åberg, Dorte Haubek, Anders Johansson
Background: The presence of Aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. Objective: To study the prevalence of A. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacterium. Design: Data from microbiological analyses of 3459 subgingival plaque samples collected from 1445 patients, 337 'younger' patients (≤35 yrs) and 1108 'older' patients (>35 yrs) during 15 years (2000-2014), has been summerized...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28747539/steroidogenesis-in-leydig-cells-effects-of-aging-and-environmental-factors
#11
Yiyan Wang, Fenfen Chen, Leping Ye, B R Zirkin, H Chen
Serum testosterone (T) levels decrease with aging in both humans and rodents. Using the rat as a model system, it was found that age-related reductions in serum T were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce T in response to luteinizing hormone (LH). Detailed analyses of the steroidogenic pathway have suggested that two defects along the pathway, LH stimulated cAMP production and cholesterol transport to and into the mitochondria, are of particular importance in age-related reductions in T production...
July 26, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28746310/hypothalamic-stem-cells-control-ageing-speed-partly-through-exosomal-mirnas
#12
Yalin Zhang, Min Soo Kim, Baosen Jia, Jingqi Yan, Juan Pablo Zuniga-Hertz, Cheng Han, Dongsheng Cai
It has been proposed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear. Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these hypothalamic cells. Each mouse model consistently displayed acceleration of ageing-like physiological changes or a shortened lifespan. Conversely, ageing retardation and lifespan extension were achieved in mid-aged mice that were locally implanted with healthy hypothalamic stem/progenitor cells that had been genetically engineered to survive in the ageing-related hypothalamic inflammatory microenvironment...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28746172/a-genetic-variant-in-the-catechol-o-methyl-transferase-comt-gene-is-related-to-age-dependent-differences-in-the-therapeutic-effect-of-calcium-channel-blockers
#13
Jiayue Xu, Adrian E Boström, Mohamed Saeed, Raghvendra K Dubey, Gérard Waeber, Peter Vollenweider, Pedro Marques-Vidal, Jessica Mwinyi, Helgi B Schiöth
Hypertension is the leading risk factor for cardiovascular disease and one of the major health concerns worldwide. Genetic factors impact both the risk for hypertension and the therapeutic effect of antihypertensive drugs. Sex- and age-specific variances in the prevalence of hypertension are partly induced by estrogen. We investigated 6 single nucleotide polymorphisms in genes encoding enzymes involved in estrogen metabolism in relation to sex- and age-specific differences in the systolic and diastolic blood pressure (SBP and DBP) outcome under the treatment of diuretics, calcium-channel blockers (CCBs), angiotensin-converting-enzyme inhibitors, and angiotensin-receptor blockers (ARBs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745971/sexuality-and-the-older-woman
#14
Penny Tremayne, Wendy Norton
Sexual health is a key public health issue. The older woman faces a number of changes to her sexual health, wellbeing and sexuality. These changes result in many older women having to adapt to a series of complex transitions that can be challenging. This article aims to identify and explore some of these changes and how they can have a significant impact on women's quality of life. Nurses play an important role in assessing and helping women to manage normal and pathological age-related changes in order to improve the sexual health of older women and ensure they receive the advice and support needed at this stage of their life...
July 27, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28745016/associations-between-self-reported-sleep-quality-and-white-matter-in-community-dwelling-older-adults-a-prospective-cohort-study
#15
Claire E Sexton, Enikő Zsoldos, Nicola Filippini, Ludovica Griffanti, Anderson Winkler, Abda Mahmood, Charlotte L Allan, Anya Topiwala, Simon D Kyle, Kai Spiegelhalder, Archana Singh-Manoux, Mika Kivimaki, Clare E Mackay, Heidi Johansen-Berg, Klaus P Ebmeier
Both sleep disturbances and decline in white matter microstructure are commonly observed in ageing populations, as well as in age-related psychiatric and neurological illnesses. A relationship between sleep and white matter microstructure may underlie such relationships, but few imaging studies have directly examined this hypothesis. In a study of 448 community-dwelling members of the Whitehall II Imaging Sub-Study aged between 60 and 82 years (90 female, mean age 69.2 ± 5.1 years), we used the magnetic resonance imaging technique diffusion tensor imaging to examine the relationship between self-reported sleep quality and white matter microstructure...
July 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28744984/redox-homeostasis-and-age-related-deficits-in-neuromuscular-integrity-and-function
#16
REVIEW
Giorgos K Sakellariou, Adam P Lightfoot, Kate E Earl, Martin Stofanko, Brian McDonagh
Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age-related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase...
July 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28744901/input-and-age-dependent-variation-in-second-language-learning-a-connectionist-account
#17
Marius Janciauskas, Franklin Chang
Language learning requires linguistic input, but several studies have found that knowledge of second language (L2) rules does not seem to improve with more language exposure (e.g., Johnson & Newport, 1989). One reason for this is that previous studies did not factor out variation due to the different rules tested. To examine this issue, we reanalyzed grammaticality judgment scores in Flege, Yeni-Komshian, and Liu's (1999) study of L2 learners using rule-related predictors and found that, in addition to the overall drop in performance due to a sensitive period, L2 knowledge increased with years of input...
July 26, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28744656/arms2-a69s-polymorphism-is-associated-with-the-number-of-ranibizumab-injections-needed-for-exudative-age-related-macular-degeneration-in-a-pro-re-nata-regimen-during-4-years-of-follow-up
#18
Alicia Valverde-Megías, Silvia Veganzones-de-Castro, Juan Donate-López, Maria Luisa Maestro-de-Las-Casas, Alicia Megías-Fresno, Julián García-Feijoo
PURPOSE: To investigate whether single-nucleotide polymorphisms (SNPs) known to be strongly associated with the development of age-related macular degeneration (AMD) have an influence on recurrence rate of choroidal neovascularization (CNV) activity during 4-year ranibizumab treatment for exudative AMD. METHODS: This prospective study included 103 treatment-naïve patients (103 eyes) that received initially a loading dose of 3 monthly ranibizumab injections and thereafter, were treated according to an as-needed regimen for a 4-year follow-up period...
July 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28744281/age-related-variations-in-intestinal-microflora-of-free-range-and-caged-hens
#19
Yizhe Cui, Qiuju Wang, Shengjun Liu, Rui Sun, Yaqiang Zhou, Yue Li
Free range feeding pattern puts the chicken in a mixture of growth materials and enteric bacteria excreted by nature, while it is typically unique condition materials and enteric bacteria in commercial caged hens production. Thus, the gastrointestinal microflora in two feeding patterns could be various. However, it remains poorly understood how feeding patterns affect development and composition of layer hens' intestinal microflora. In this study, the effect of feeding patterns on the bacteria community in layer hens' gut was investigated using free range and caged feeding form...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28744225/is-it-time-to-begin-a-public-campaign-concerning-frailty-and-pre-frailty-a-review-article
#20
REVIEW
Jerzy Sacha, Magdalena Sacha, Jacek Soboń, Zbigniew Borysiuk, Piotr Feusette
Frailty is a state that encompasses losses in physical, psychological or social domains. Therefore, frail people demonstrate a reduced potential to manage external stressors and to respond to life incidents. Consequently, such persons are prone to various adverse consequences such as falls, cognitive decline, infections, hospitalization, disability, institutionalization, and death. Pre-frailty is a condition predisposing and usually preceding the frailty state. Early detection of frailty (i.e., pre-frailty) may present an opportunity to introduce effective management to improve outcomes...
2017: Frontiers in Physiology
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