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https://www.readbyqxmd.com/read/28934789/lack-of-gender-and-age-differences-in-pain-measurements-following-exercise-in-people-with-chronic-whiplash-associated-disorders
#1
Kelly Ickmans, Anneleen Malfliet, Margot De Kooning, Lisa Goudman, Ives Hubloue, Tom Schmitz, Dorien Goubert, Maria Encarnacion Aguilar-Ferrandiz
BACKGROUND: Individuals with chronic whiplash associated disorders (WAD) present persistent pain in the absence of structural pathology. In these people, altered central pain processing and central sensitization are observed. The role of personal factors, such as gender and age, on pain processing mechanisms in chronic WAD, however, is still unclear. OBJECTIVES: This study investigated possible gender- and age-related differences in self-reported and experimental pain measurements in people with chronic WAD...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934619/distinct-brain-metabolic-patterns-separately-associated-with-cognition-motor-function-and-aging-in-parkinson-s-disease-dementia
#2
Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L Goertzen, Andrew Borys, Douglas E Hobson, Seok Min Kim, Chong Sik Lee
We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [(18)F]fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis...
August 31, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28934529/traveling-slow-oscillations-during-sleep-a-marker-of-brain-connectivity-in-childhood
#3
Salome Kurth, Brady A Riedner, Douglas C Dean, Jonathan O'Muircheartaigh, Reto Huber, Oskar G Jenni, Sean C L Deoni, Monique K LeBourgeois
Slow oscillations, a defining characteristic of the nonrapid eye movement sleep electroencephalogram (EEG), proliferate across the scalp in highly reproducible patterns. In adults, the propagation of slow oscillations is a recognized fingerprint of brain connectivity and excitability. In this study, we (1) describe for the first time maturational features of sleep slow oscillation propagation in children (n = 23; 2-13 years) using high-density (hd) EEG and (2) examine associations between sleep slow oscillatory propagation characteristics (ie, distance, traveling speed, cortical involvement) and white matter myelin microstructure as measured with multicomponent Driven Equilibrium Single Pulse Observation of T1 and T2-magnetic resonance imaging (mcDESPOT-MRI)...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934461/effect-of-priming-with-seasonal-influenza-a-h3n2-virus-on-the-prevalence-of-cross-reactive-hemagglutination-inhibition-antibodies-to-swine-origin-a-h3n2-variants
#4
Feng Liu, Vic Veguilla, F Liaini Gross, Eric Gillis, Thomas Rowe, Xiyan Xu, Terrence M Tumpey, Jacqueline M Katz, Min Z Levine, Xiuhua Lu
Background: Recent outbreaks of swine-origin influenza A(H3N2) variant (H3N2v) viruses have raised public health concerns. Previous studies indicated that older children and young adults had the highest levels of hemagglutination-inhibition (HI) antibodies to 2010-2011 H3N2v viruses. However, newly emerging 2013 H3N2v have acquired antigenic mutations in the hemagglutinin at amino acid position 145 (N145K/R). We estimated the levels of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934439/age-related-differences-in-influenza-b-infection-by-lineage-in-a-community-based-sentinel-system-2010-2011-to-2015-2016-canada
#5
Danuta M Skowronski, Catharine Chambers, Gaston De Serres, Suzana Sabaiduc, Anne-Luise Winter, James A Dickinson, Jonathan B Gubbay, Kevin Fonseca, Steven J Drews, Hugues Charest, Christine Martineau, Mel Krajden, Martin Petric, Nathalie Bastien, Yan Li
Age-related differences in influenza B lineage detection were explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2010-2011 to 2015-2016. Whereas >80% of B(Victoria) cases were <40 years old, B(Yamagata) cases showed a bimodal age distribution with 27% who were <20 years old and 61% who were 30-64 years old, but with a notable gap in cases between 20 and 29 years old (4%). Overall, the median age was 20 years lower for B(Victoria) vs B(Yamagata) cases (20 vs 40 years; P < ...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934075/gerontological-education-course-and-experiential-differences-across-academic-colleges
#6
Hardeep K Obhi, Jennifer A Margrett, Yan Su, Sarah L Francis, Young-A Lee, Denise A Crawford, Warren D Franke
A knowledgeable workforce is key to meeting the demands of an aging population that is expected to nearly triple by 2030 and attitudes influence propensity to seek aging-related careers. Post-secondary education offers an opportunity to increase aging-related knowledge and facilitates intergenerational experiential-learning opportunities; however, research is lacking regarding attitudes towards aging and experiences among an academically diverse sample. To address this gap, the aims of this study were to: (1) examine differences in students' attitudes toward older adults by academic college; (2) assess differences in aging-related coursework and course experiences by academic college; and (3) explore key factors associated with students' attitudes toward older adults...
September 21, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28933517/new-treatment-modalities-for-neovascular-age-related-macular-degeneration
#7
Patricio G Schlottmann, Arturo A Alezzandrini, Marcelo Zas, Francisco J Rodriguez, José D Luna, Lihteh Wu
Age-related macular degeneration (AMD) is considered one of the main causes of severe vision loss in older adults. The neovascular form (nAMD) is an advanced stage, which is responsible for the most severe vision loss. Vascular endothelial growth factor (VEGF) is at present the main factor that leads to the development of a neovascular membrane and the increased leakage from the membrane to the retina. At present, anti-VEGF therapy is the only treatment that achieves vision gains in many patients and halts progression in most of them...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28933356/the-association-between-dietary-intake-of-antioxidants-and-ocular-disease
#8
Andrea Braakhuis, Ryan Raman, Ehsan Vaghefi
To assess the association between dietary antioxidant intake and the incidence of the three major oxidative stress-related eye diseases, cataracts, glaucoma, and age-related macular degeneration, 78 cases from the University of Auckland Optometry and Vision Science clinic and 149 controls were recruited. Participants completed an antioxidant food-frequency questionnaire, analysed through multiple logistic regression. Protective associations were identified with higher consumption of fruit and vegetables (OR = 0...
January 30, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28933064/the-influence-of-adipose-tissue-on-brain-development-cognition-and-risk-of-neurodegenerative-disorders
#9
Liliana Letra, Isabel Santana
The brain is a highly metabolic organ and thus especially vulnerable to changes in peripheral metabolism, including those induced by obesity-associated adipose tissue dysfunction. In this context, it is likely that the development and maturation of neurocognitive circuits may also be affected and modulated by metabolic environmental factors, beginning in utero. It is currently recognized that maternal obesity, either pre-gestational or gestational, negatively influences fetal brain development and elevates the risk of cognitive impairment and neuropsychiatric disorders in the offspring...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28932625/vascular-aging-implications-for-cardiovascular-disease-and-therapy
#10
Yohannes T Ghebre, Eduard Yakubov, Wing Tak Wong, Prasanna Krishnamurthy, Nazish Sayed, Andrew G Sikora, Mark D Bonnen
The incidence and prevalence of cardiovascular disease is highest among the elderly, in part, due to deleterious effects of advancing age on the heart and blood vessels. Aging, a known cardiovascular risk factor, is progressively associated with structural and functional changes to the vasculature including hemodynamic disturbance due to increased oxidative stress, premature cellular senescence and impairments in synthesis and/or secretion of endothelium-derived vasoactive molecules. These molecular and physiological changes lead to vessel wall stiffening and thickening, as well as other vascular complications that culminate to loss of vascular tone regulation and endothelial function...
December 2016: Translational Medicine: Current Research
https://www.readbyqxmd.com/read/28932343/babies-smell-wonderful-to-their-parents-teenagers-do-not-an-exploratory-questionnaire-study-on-children-s-age-and-personal-odor-ratings-in-a-polish-sample
#11
Ilona Croy, Tomasz Frackowiak, Thomas Hummel, Agnieszka Sorokowska
INTRODUCTION: Infant body odor is subjectively pleasant to parents and activates reward areas in the brain. Hence, body odor perception might contribute to parental bonding. However, it is unknown whether the perceived pleasantness of children's body odor varies over the course of a child's development. METHODS: Two hundred and thirty-five parents (M = 36.9 years, SD = 7.3) were asked to assess the personal odor pleasantness of their children (N = 367; M = 9...
2017: Chemosensory Perception
https://www.readbyqxmd.com/read/28932005/association-between-hand-muscle-thickness-and-whole-body-skeletal-muscle-mass-in-healthy-adults-a-pilot-study
#12
Akio Morimoto, Tadashi Suga, Nobuaki Tottori, Michio Wachi, Jun Misaki, Ryo Tsuchikane, Tadao Isaka
[Purpose] Handgrip strength is a surrogate indicator for assessing disease-related and age-related skeletal muscle loss. Clinical utility as such a surrogate can be at least partially explained by the close relationship between handgrip strength and whole-body skeletal muscle mass. The handgrip strength is related to hand muscle size. Thus, the present study examined whether hand muscle thickness is associated with whole-body skeletal muscle mass. [Subjects and Methods] Thirty healthy male adults participated in this study...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931831/hyperhomocysteinemia-alters-retinal-endothelial-cells-barrier-function-and-angiogenic-potential-via-activation-of-oxidative-stress
#13
Riyaz Mohamed, Isha Sharma, Ahmed S Ibrahim, Heba Saleh, Nehal M Elsherbiny, Sadanand Fulzele, Khaled Elmasry, Sylvia B Smith, Mohamed Al-Shabrawey, Amany Tawfik
Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in DR and AMD. Our previous work revealed that HHcy altered BRB in retinal endothelial cells in vivo. Here we hypothesize that homocysteine (Hcy) alters retinal endothelial cell barrier function and angiogenic potential via activation of oxidative stress. Human retinal endothelial cells (HRECs) treated with and without different concentrations of Hcy showed a reduction of tight junction protein expression, increased FITC dextran leakage, decreased transcellular electrical resistance and increased angiogenic potential...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931353/blueberry-supplementation-attenuates-microglia-activation-and-increases-neuroplasticity-in-mice-consuming-a-high-fat-diet
#14
Amanda N Carey, Kelsea R Gildawie, Abigail Rovnak, Nopporn Thangthaeng, Derek R Fisher, Barbara Shukitt-Hale
OBJECTIVES: Consuming a high-fat diet (HFD) may result in behavioral deficits similar to those observed in aging animals. Blueberries may prevent and even reverse age-related alterations in neurochemistry and behavior. It was previously demonstrated that middle-aged mice fed HFD had impaired memory; however, supplementation of HFD with blueberry reduced these memory deficits. As a follow-up to that study, the brain tissue from HFD-fed mice with and without blueberry supplementation was assessed to determine the neuroprotective mechanism(s) by which blueberry allayed cognitive dysfunction associated with HFD...
September 21, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28931301/oxidative-stress-assessment-in-alzheimer-s-disease-a-clinic-setting-study
#15
Andrea Vergallo, Linda Giampietri, Filippo Baldacci, Leda Volpi, Lucia Chico, Cristina Pagni, Filippo Sean Giorgi, Roberto Ceravolo, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli
BACKGROUND: Oxidative stress (OS) is a physiological age-related brain process, dramatically overexpressed in neurodegenerative disorders like Alzheimer's disease (AD). Nevertheless, the pathophysiological role of OS in AD pathology has not been clarified yet. OS as a biomarker for AD is a controversial issue. A comparison of previous data is difficult due to a remarkable methodological variability. Most of the previous studies have shown higher levels of OS markers and lower antioxidant power in patients with dementia when compared to mild cognitive impairment (MCI) and healthy controls...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28931202/different-sized-incisions-for-phacoemulsification-in-age-related-cataract
#16
REVIEW
Chongfei Jin, Xinyi Chen, Andrew Law, Yunhee Kang, Xue Wang, Wen Xu, Ke Yao
BACKGROUND: Age-related cataract is the principal cause of blindness and visual impairment in the world. Phacoemulsification is the main surgical procedure used to treat cataract. The comparative effectiveness and safety of different-sized incisions for phacoemulsification has not been determined. OBJECTIVES: The aim of this systematic review was to assess the effectiveness and safety of smaller versus larger incisions for phacoemulsification in age-related cataract...
September 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28930884/rate-of-macular-ganglion-cell-inner-plexiform-layer-thinning-in-glaucomatous-eyes-with-vascular-endothelial-growth-factor-inhibition
#17
Won June Lee, Young Kook Kim, Yong Woo Kim, Jin Wook Jeoung, Seok Hwan Kim, Jang Won Heo, Hyeong Gon Yu, Ki Ho Park
PURPOSE: To evaluate the rate of progressive macular ganglion cell-inner plexiform layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal anti-vascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS: This study was a retrospective modified case control study with fellow-eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography (HD-OCT)...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28930849/analysis-of-risk-factors-for-colonic-diverticular-bleeding-and-recurrence
#18
Masato Taki, Tadayuki Oshima, Katsuyuki Tozawa, Yukako Taniguchi, Toshihiko Tomita, Yoshio Ohda, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
The increase in incidence of colonic diverticular bleeding is relative to an age-related rise in the incidence of colonic diverticulosis and use of antithrombotic medication. However, risk factors related to the onset, recurrence, and prophylaxis have not been established. Therefore, we aimed to determine risk factors for the onset and recurrence of colonic diverticular bleeding.An age- and sex-matched case-control study was performed to assess the risk factors for the onset of colonic diverticular bleeding...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930640/age-related-decline-in-endurance-running-performance-an-example-of-a-multiple-world-records-holder
#19
Romuald Lepers, Thomas Cattagni
This study examined the age-related decline in endurance running performance of one of the greatest master runners ever, Ed Whitlock. His running performances from 1500 m to marathon were analyzed for five periods of 5 years from 65-69 years to 85-89 years. Despite exceptional running performances for his advanced age, the rate of decline in his performances increased after 80 years and was drastically amplified after 85 years.
September 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28930609/age-related-pathological-changes-in-the-pancreas
#20
Yoko Matsuda
Pancreas has a complex histology and is characterized by a combination of endocrine and exocrine cells. Pancreas undergoes various pathological changes with aging characterized by increased fatty replacement, fibrosis, lymphoplasmacytic infiltration, amyloid deposition, a decreased weight as well as development of intra-epithelial neoplastic changes. These age-related alterations lead to diabetes mellitus and can predispose the individual to pancreatic ductal adenocarcinoma. In this review, we summarize age-related morphological and pathological changes of aging in pancreas...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
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