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https://www.readbyqxmd.com/read/27919895/plazomicin-activity-against-346-extended-spectrum-%C3%AE-lactamase-ampc-producing-escherichia-coli-urinary-isolates-related-to-aminoglycoside-modifying-enzymes-characterized
#1
Maria Del Carmen López-Diaz, Esther Culebras, Iciar Rodríguez-Avial, Esther Rios, José Manuel Viñuela-Prieto, Juan J Picazo, Carmen Rodríguez-Avial
The activity of plazomicin and clinically relevant aminoglycosides were tested against 346 ESBL/AmpC-producer Escherichia coli urinary isolates and the results were correlated with the presence of aminoglycoside-modifying enzymes (AMEs).Data showed that plazomicin was very active against all ESBL/AmpC-producing E. coli urinary isolates. Its activity was not related to the AME genes studied.
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919890/prevalence-of-esbl-and-or-carbapenemase-producing-escherichia-coli-isolated-from-yellow-legged-gulls-from-barcelona-spain
#2
Andrea Vergara, Cristina Pitart, Tomás Montalvo, Ignasi Roca, Sara Sabaté, Juan Carlos Hurtado, Raquel Planell, Francesc Marco, Beatriz Ramírez, Víctor Peracho, Mercé de Simón, Jordi Vila
Seventy two (54.5%) out of 132 fecal samples were positive for either extended spectrum beta-lactamases (ESBL) (51.5%), carbapenemase (1.5%) or cephamycinase (1.5%) producing Escherichia coli from a group of yellow-legged gulls in Barcelona, Spain. The isolation of two carbapenemase-producing E. coli strains is a matter of concern.
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919513/-rapid-test-for-detection-of-susceptibility-to-cefotaxime-in-enterobacteriaceae
#3
Gemma Jiménez-Guerra, Yannik Hoyos-Mallecot, Javier Rodríguez-Granger, José María Navarro-Marí, José Gutiérrez-Fernández
In this work an "in house" rapid test based on the change in pH that is due to hydrolysis for detecting Enterobacteriaceae susceptible to cefotaxime is evaluated. The strains of Enterobacteriaceae from 1947 urine cultures were assessed using MicroScan panels and the "in house" test. This rapid test includes red phenol solution and cefotaxime. Using MicroScan panels, 499 Enterobacteriaceae isolates were evaluated, which included 27 isolates of Escherichia coli producing extended-spectrum beta-lactamases (ESBL), 16 isolates of Klebsiella pneumoniae ESBL and 1 isolate of Klebsiella oxytoca ESBL...
December 2, 2016: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/27916621/point-should-inhaled-antibiotic-therapy-be-routinely-used-for-the-treatment-of-bacterial-lower-respiratory-tract-infections-in-the-icu-setting-yes
#4
EDITORIAL
Richard G Wunderink
Routine use of aerosolized antibiotics is the most rational approach to the current treatment dilemmas for severe hospital-acquired pneumonia (HAP) requiring endotracheal intubation or ventilator-associated pneumonia (VAP). The two main issues for HAP/VAP are inappropriate initial therapy and ineffective therapy for multidrug resistant (MDR) pathogens, particularly gram negative bacilli such as Pseudomonas aeruginosa and Acinetobacter species. The emergence of extended spectrum beta-lactamases (ESBL) and carbapenem resistance in Enterobacteriaceae (CRE) have made even common pathogens such as Escherichia coli difficult to treat...
November 22, 2016: Chest
https://www.readbyqxmd.com/read/27916471/the-efficacy-of-faropenem-for-patients-with-acute-cystitis-caused-by%C3%A2-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli
#5
Keiko Fujino, Yoshiki Hiyama, Teruhisa Uehara, Koji Ichihara, Jiro Hashimoto, Satoshi Fujii, Masaaki Shinagawa, Satoshi Takahashi, Naoya Masumori
The number of patients with acute cystitis caused by extended spectrum β lactamase (ESBL)-producing Escherichia coli (E. coli) is increasing gradually. Although it is reported that ESBL-producing E. coli are sensitive to faropenem (FRPM), there are few clinical studies on the efficiency of FRPM against acute cystitis caused by the bacteria. Therefore, we retrospectively reviewed the medical charts of patients with acute cystitis caused by ESBL-producing E. coli who were treated with the oral antimicrobial agent faropenem (FRPM) in our institution from June 2011 to May 2015...
December 2, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27911458/spondylodiscitis-a-rare-complication-following-percutaneous-nephrostomy
#6
Francesco Chiancone, Maurizio Fedelini, Clemente Meccariello, Luigi Pucci, Marco Fabiano, Paolo Fedelini
Spondylodiscitis is an inflammation of the intervertebral disc and the adjacent vertebral bodies. The spondylodiscitis can not only be a complication of medical interventions such as an operation near spinal column but also urogenital and vascular interventions and intravenous catheter use. A 71-year-old man was admitted to our emergency department with fever and severe abdominal pain. Antibiotic therapy had been performed with intravenous administration of 2 g of ceftriaxone and the patient underwent the placement of a percutaneous nephrostomy according to Seldinger technique...
November 28, 2016: Urologia
https://www.readbyqxmd.com/read/27905467/direct-identification-of-antibiotic-resistance-genes-on-single-plasmid-molecules-using-crispr-cas9-in-combination-with-optical-dna-mapping
#7
Vilhelm Müller, Fredrika Rajer, Karolin Frykholm, Lena K Nyberg, Saair Quaderi, Joachim Fritzsche, Erik Kristiansson, Tobias Ambjörnsson, Linus Sandegren, Fredrik Westerlund
Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in nanofluidic channels, which provides detailed information about the plasmids present in a bacterial isolate. In a single experiment, we obtain the number of different plasmids in the sample, the size of each plasmid, an optical barcode that can be used to identify and trace the plasmid of interest and information about which plasmid that carries a specific resistance gene...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904884/escherichia-coli-sequence-type-131-h30-is-the-main-driver-of-emerging-extended-spectrum-%C3%AE-lactamase-producing-e-coli-at-a-tertiary-care-center
#8
James R Johnson, Brian Johnston, Paul Thuras, Bryn Launer, Evgeni V Sokurenko, Loren G Miller
The H30 strain of Escherichia coli sequence type 131 (ST131-H30) is a recently emerged, globally disseminated lineage associated with fluoroquinolone resistance and, via its H30Rx subclone, the CTX-M-15 extended-spectrum beta-lactamase (ESBL). Here, we studied the clonal background and resistance characteristics of 109 consecutive recent E. coli clinical isolates (2015) and 41 historical ESBL-producing E. coli blood isolates (2004 to 2011) from a public tertiary care center in California with a rising prevalence of ESBL-producing E...
November 2016: MSphere
https://www.readbyqxmd.com/read/27903600/improved-accuracy-of-cefepime-susceptibility-testing-for-esbl-producing-enterobacteriaceae-using-an-on-demand-digital-dispensing-method
#9
Kenneth P Smith, Thea Brennan-Krohn, Susan Weir, James E Kirby
Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae generally cannot be treated with penicillins and cephalosporins. However, some later generation cephalosporins, including cefepime, are poorly hydrolyzed by specific ESBL enzymes, and certain strains demonstrate in vitro susceptibility to these agents, potentially affording additional treatment opportunities. Moreover, the ability to adjust both dose and dosing interval of β-lactam agents allows treatment of strains with elevated minimal inhibitory concentrations (MICs) formerly classified in the intermediate range...
November 30, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27902433/escherichia-coli-clonal-group-a-cga-among-uropathogenic-infections-in-mexico-city
#10
Angel Manjarrez-Hernandez, José Molina-López, Sandra Gavilanes-Parra, Rigoberto Hernandez-Castro
Escherichia coli clonal group A (CGA) causes urinary tract and other extraintestinal infections in humans. CGA is an important cause of trimethoprim/sulfamethoxazole (SXT)-resistance in extraintestinal pathogens. We examined the extent to which resistance in this area is related to CGA dissemination of E. coli from urinary tract infections (UTIs) in Mexico City. The virulence backgrounds of the isolates were also characterized. In this study, the frequency of resistance to SXT used for UTI treatment was high (56-65%) and CGA isolates accounted for 9 of the 78 SXT-resistant isolates (11...
November 7, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902398/clonal-spread-and-accumulation-of-beta-lactams-resistance-determinants-in-enterobacter-aerogenes-and-enterobacter-cloacae-complex-isolates-from-infection-and-colonization-in-patients-at-a-public-hospital-in-recife-pernambuco-brazil
#11
Adriane Borges Cabral, Maria Amélia Vieira Maciel, Josineide Ferreira Barros, Marcelo Maranhão Antunes, Célia Maria Machado Barbosa de Castro, Ana Catarina Souza Lopes
Enterobacter aerogenes and Enterobacter cloacae complex are the species of this genus most involved in healthcare-associated infections (HAIs), that are ESBL and carbapenemase producers. This study has characterized phenotypically and genotypically 51 isolates of E. aerogenes and E. cloacae complex as originated from infection or colonization in patients admitted to public hospital in Recife, Pernambuco, Brazil, by antimicrobial susceptibility profile, analysis of β-lactamase genes (blaTEM, blaSHV, blaCTX-M, blaKPC, blaVIM, blaIMP and blaSPM), PCR and DNA sequencing, plasmid profile and ERIC-PCR...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902381/detection-of-escherichia-coli-st131-complex-st705-and-klebsiella-pneumoniae-st15-among-fecal-carriage-of-extended-spectrum-betalactamase-and-carbapenemase-producing-enterobacteriaceae
#12
Esther Rios, Maria Carmen López, Iciar Rodríguez-Avial, Esther Culebras, Juan Jose Picazo
The objective of the present study was to evaluate the prevalence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and carbapenemases-producing Enterobacteriaceae (CPE) in non-selected hospitalized and non-hospitalized patients from the same geographic area of Madrid. Among the 501 patients enrolled, 43 (8.6%) carried ESBL-E and 8 (1.6%) patients exhibited CPE. The main intestinal colonizer among ESBL-E was CTX-M-producing Escherichia coli isolates in both settings (community and hospital)...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27899921/high-prevalence-of-%C3%AE-lactamase-and-plasmid-mediated-quinolone-resistance-genes-in-extended-spectrum-cephalosporin-resistant-escherichia-coli-from-dogs-in-shaanxi-china
#13
Xiaoqiang Liu, Haixia Liu, Yinqian Li, Caiju Hao
Objective: The aim of this study was to investigate the occurrence and molecular characterization of extended-spectrum β-lactamases (ESBL), plasmid-mediated AmpC β-lactamase (pAmpC) and carbapenemases as well as plasmid-mediated quinolone-resistant (PMQR) among extended-spectrum cephalosporin-resistant (ESC-R) Escherichia coli from dogs in Shaanxi province in China. Methods: A total of 40 ESC-R Escherichia coli selected from 165 Extraintestinal pathogenic E. coli (ExPEC) isolated from dogs were screened and characterized for the genes encoding for the ESBLs, pAmpC, carbapenemases and PMQR genes by PCR and sequencing...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27898030/assessment-of-the-activity-of-tigecycline-against-gram-positive-and-gram-negative-organisms-collected-from-italy-between-2012-and-2014-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t
#14
Stefania Stefani, Michael J Dowzicky
As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T) we report the in vitro activity of tigecycline and its comparators against Gram-negative and Gram-positive organisms collected from Italian centers between 2012 and 2014. Minimum inhibitory concentrations were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute, and antimicrobial resistance was determined using the European Committee on Antimicrobial Susceptibility Testing interpretive criteria...
November 26, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27895637/high-prevalence-of-esbl-producing-klebsiella-pneumoniae-causing-community-onset-infections-in-china
#15
Jing Zhang, Kai Zhou, Beiwen Zheng, Lina Zhao, Ping Shen, Jinru Ji, Zeqing Wei, Lanjuan Li, Jianying Zhou, Yonghong Xiao
The aim of this work was to investigate the epidemiological and genetic characteristics of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) causing community-onset infections. K. pneumoniae isolates were collected from 31 Chinese secondary hospitals between August 2010 and 2011. Genes encoding ESBL and AmpC beta-lactamases were detected by PCR. The isolates were assigned to sequence types (STs) using multi-locus sequence typing (MLST). Eleven ESBL-Kp strains were selected for whole-genome sequencing (WGS) for investigating the genetic environment and plasmids encoding ESBL genes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27894763/extended-spectrum-beta-lactamase-esbl-producing-bacteria-urinary-tract-infections-and-complex-pediatric-urology
#16
Ruth Wragg, Anna Harris, Mitul Patel, Andrew Robb, Harish Chandran, Liam McCarthy
AIM OF THE STUDY: Extended spectrum beta lactamase (ESBL) producing bacteria are resistant to most beta-lactam antibiotics including third-generation cephalosporins, quinolones and aminoglycosides. This resistance is plasmid-borne and can spread between species. Management of ESBL is challenging in children with recurrent urinary tract infections (UTIs) and complex urological abnormalities. We aim to quantify the risk in children and specifically in urological patients. METHODS: Retrospective review of a microbiology database (April 2014 to November 2015)...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27892858/longitudinal-study-of-ctx-m-esbl-producing-e-coli-strains-on-a-uk-dairy-farm
#17
R A Horton, D Duncan, L P Randall, S Chappell, L A Brunton, R Warner, N G Coldham, C J Teale
The aim of this study was to investigate the bacterial strains and farm environment that may contribute to the persistence of ESBL-producing E. coli on a single UK dairy farm. A longitudinal study was conducted comprising 6 visits, between August and October 2010, followed by a further visit at approximately 69weeks after the initial visit. Faecal and environmental samples were collected from different parts of the farm. The persistence and extent of faecal shedding of ESBL E. coli by individual calves was also determined...
September 30, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27891664/healthcare-costs-doubled-when-children-had-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-bacteria
#18
Oona Nieminen, Matti Korppi, Merja Helminen
AIM: The impact of the emergence of antimicrobial resistant organisms has rarely been studied in children, including the healthcare costs of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria. We evaluated the effect of ESBL on UTI healthcare costs and risk factors for paediatric UTIs. METHODS: This retrospective case-control study covered 2005-2014 and focused on children below 16 years of age treated in a University hospital: 22 children with UTIs caused by ESBL-producing bacteria and 56 ESBL-negative UTI controls...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27890813/international-travel-is-a-risk-factor-for-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-acquisition-in-children-a-case-case-control-study-in-an-urban-u-s-hospital
#19
Jonathan P Strysko, Vidya Mony, Jeremiah Cleveland, Hanna Siddiqui, Peter Homel, Christina Gagliardo
BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL) infections are increasing in both adults and children. The aim of this study was to describe the epidemiology of children with ESBL in an ethnically-diverse population, to determine what proportion of these infections were community-onset, and to identify risk factors predisposing children to ESBL acquisition. METHODS: A case-case-control study of children aged 0-18 years was conducted from 2012 to 2014...
November 24, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27890442/predominance-of-healthcare-associated-cases-among-episodes-of-community-onset-bacteraemia-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#20
Jean-Ralph Zahar, Philippe Lesprit, Stephane Ruckly, Aurelia Eden, Hitoto Hikombo, Louis Bernard, Stephan Harbarth, Jean-François Timsit, Christian Brun-Buisson
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) are endemic pathogens worldwide. Infection with ESBL-PE may be associated with inadequate antibiotic therapy and a poor outcome. However, risk factors for ESBL-PE community-acquired infections are ill-defined. An observational multicentre study was performed in 50 hospitals to identify the prevalence of and risk factors for community-acquired ESBL-PE bacteraemia. All patients presenting with community-onset Enterobacteriaceae bacteraemia were recorded over a 2-month period (between June and November 2013)...
November 16, 2016: International Journal of Antimicrobial Agents
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