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https://www.readbyqxmd.com/read/28655210/diagnosis-and-management-of-myocardial-involvement-in-systemic-immune-mediated-diseases-a-position-statement-of-the-european-society-of-cardiology-working-group-on-myocardial-and-pericardial-disease
#1
Alida L P Caforio, Yehuda Adler, Carlo Agostini, Yannick Allanore, Aris Anastasakis, Michael Arad, Michael Böhm, Philippe Charron, Perry M Elliott, Urs Eriksson, Stephan B Felix, Pablo Garcia-Pavia, Eric Hachulla, Stephane Heymans, Massimo Imazio, Karin Klingel, Renzo Marcolongo, Marco Matucci Cerinic, Antonis Pantazis, Sven Plein, Valeria Poli, Angelos Rigopoulos, Petar Seferovic, Yehuda Shoenfeld, Josè L Zamorano, Ales Linhart
No abstract text is available yet for this article.
June 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28655169/hospital-at-home-integrated-care-programme-for-the-management-of-disabling-health-crises-in-older-patients-comparison-with-bed-based-intermediate-care
#2
Miquel À Mas, Marco Inzitari, Sergi Sabaté, Sebastià J Santaeugènia, Ramón Miralles
Objective: to analyse the clinical impact of a home-based Intermediate Care model in the Catalan health system, comparing it with usual bed-based care. Design: quasi-experimental longitudinal study. Setting: hospital Municipal de Badalona and El Carme Intermediate Care Hospital, Badalona, Catalonia, Spain. Participants: we included older patients with medical and orthopaedic disabling health crises in need of Comprehensive Geriatric Assessment (CGA) and rehabilitation...
June 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28654819/the-expression-of-connexins-and-sox2-reflects-the-plasticity-of-glioma-stem-like-cells
#3
Joana Balça-Silva, Diana Matias, Luiz Gustavo Dubois, Brenno Carneiro, Anália do Carmo, Henrique Girão, Fernanda Ferreira, Valeria Pereira Ferrer, Leila Chimelli, Paulo Niemeyer Filho, Hermínio Tão, Olinda Rebelo, Marcos Barbosa, Ana Bela Sarmento-Ribeiro, Maria Celeste Lopes, Vivaldo Moura-Neto
Glioblastoma (GBM) is the most malignant primary brain tumor, with an average survival rate of 15 months. GBM is highly refractory to therapy, and such unresponsiveness is due, primarily, but not exclusively, to the glioma stem-like cells (GSCs). This subpopulation express stem-like cell markers and is responsible for the heterogeneity of GBM, generating multiple differentiated cell phenotypes. However, how GBMs maintain the balance between stem and non-stem populations is still poorly understood. We investigated the GBM ability to interconvert between stem and non-stem states through the evaluation of the expression of specific stem cell markers as well as cell communication proteins...
June 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28654785/global-incidence-of-oral-and-oropharynx-cancer-in-patients-younger-than-45-years-versus-older-patients-a%C3%A2-systematic-review
#4
REVIEW
Aisha A Hussein, Marco N Helder, Jan G de Visscher, C René Leemans, Boudewijn J Braakhuis, Henrica C W de Vet, Tymour Forouzanfar
Head and neck squamous cell carcinoma (HNSCC) is typically regarded as a disease of elderly people. However, increasing numbers of patients worldwide with HNSCC at younger age (defined as <45 years old) have been reported in recent years. To assess geographical variations and trends worldwide in incidence of oral and oropharyngeal cancer in young patients, a systematic review was conducted in PubMed and Google scholar databases from 1975 to June 2016. Seventy-eight studies were selected for further study...
June 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28654692/heart-rate-variability-as-predictor-of-mortality-in-sepsis-a-prospective-cohort-study
#5
Fábio M de Castilho, Antonio Luiz P Ribeiro, José Luiz P da Silva, Vandack Nobre, Marcos R de Sousa
BACKGROUND: Sepsis is a serious medical condition with increasing prevalence and high mortality. The role of the autonomic nervous system in pathophysiology of sepsis has been increasingly researched. The objective of this study is to evaluate the Heart rate variability (HRV) as a predictor of mortality in septic patients. METHODS: This was a prospective cohort of patients diagnosed with sepsis. Patient recruitment was carried out at ICU in tertiary university hospital between March 2012 and February 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28654678/genetic-factors-affecting-ebv-copy-number-in-lymphoblastoid-cell-lines-derived-from-the-1000-genome-project-samples
#6
Rajendra Mandage, Marco Telford, Juan Antonio Rodríguez, Xavier Farré, Hafid Layouni, Urko M Marigorta, Caitlin Cundiff, Jose Maria Heredia-Genestar, Arcadi Navarro, Gabriel Santpere
Epstein-Barr virus (EBV), human herpes virus 4, has been classically associated with infectious mononucleosis, multiple sclerosis and several types of cancers. Many of these diseases show marked geographical differences in prevalence, which points to underlying genetic and/or environmental factors. Those factors may include a different susceptibility to EBV infection and viral copy number among human populations. Since EBV is commonly used to transform B-cells into lymphoblastoid cell lines (LCLs) we hypothesize that differences in EBV copy number among individual LCLs may reflect differential susceptibility to EBV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28654500/commentary-on-physical-exercise-and-physical-activity-for-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-literature-review
#7
Patrick van der Torre, Marco van Brussel
No abstract text is available yet for this article.
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654365/treatment-efficacy-adherence-and-quality-of-life-among-women-younger-than-35-years-in-the-international-breast-cancer-study-group-text-and-soft-adjuvant-endocrine-therapy-trials
#8
Poornima Saha, Meredith M Regan, Olivia Pagani, Prudence A Francis, Barbara A Walley, Karin Ribi, Jürg Bernhard, Weixiu Luo, Henry L Gómez, Harold J Burstein, Vani Parmar, Roberto Torres, Josephine Stewart, Meritxell Bellet, Antonia Perelló, Faysal Dane, Antonio Moreira, Daniel Vorobiof, Michelle Nottage, Karen N Price, Alan S Coates, Aron Goldhirsch, Richard D Gelber, Marco Colleoni, Gini F Fleming
Purpose To describe benefits and toxicities of adjuvant endocrine therapies in women younger than 35 years with breast cancer (n = 582) enrolled in the Suppression of Ovarian Function Trial (SOFT) and Tamoxifen and Exemestane Trial (TEXT). Methods In SOFT, women still premenopausal after surgery with or without chemotherapy were randomly assigned to tamoxifen alone, tamoxifen plus ovarian function suppression (OFS), or exemestane plus OFS. In TEXT, all received OFS with or without concomitant chemotherapy and were randomly assigned to exemestane plus OFS or tamoxifen plus OFS...
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28654357/patients-with-paediatric-onset-multiple-sclerosis-are-at-higher-risk-of-cognitive-impairment-in-adulthood-an-italian-collaborative-study
#9
Luis Ruano, Mariana Branco, Emilio Portaccio, Benedetta Goretti, Claudia Niccolai, Francesco Patti, Clara Chisari, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Marta Simone, Rosa Gemma Viterbo, Maria Pia Amato
BACKGROUND: Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term cognitive outcomes. OBJECTIVE: To compare the prevalence and profile of CI between adults with a history of POMS and those with classic, adult-onset multiple sclerosis (AOMS). METHODS: Cognitive performance was assessed through the Brief Repeatable Battery (BRB) and the Stroop Test in consecutive patients referred to six Italian MS centres...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28654327/a-new-facet-of-vitamin-b12-gene-regulation-by-cobalamin-based-photoreceptors
#10
S Padmanabhan, Marco Jost, Catherine L Drennan, Montserrat Elías-Arnanz
Living organisms sense and respond to light, a crucial environmental factor, using photoreceptors, which rely on bound chromophores such as retinal, flavins, or linear tetrapyrroles for light sensing. The discovery of photoreceptors that sense light using 5'-deoxyadenosylcobalamin, a form of vitamin B12 that is best known as an enzyme cofactor, has expanded the number of known photoreceptor families and unveiled a new biological role of this vitamin. The prototype of these B12-dependent photoreceptors, the transcriptional repressor CarH, is widespread in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response...
June 20, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28654243/mitochondria-targeted-triphenylphosphonium-based-compounds-syntheses-mechanisms-of-action-and-therapeutic-and-diagnostic-applications
#11
Jacek Zielonka, Joy Joseph, Adam Sikora, Micael Hardy, Olivier Ouari, Jeannette Vasquez-Vivar, Gang Cheng, Marcos Lopez, Balaraman Kalyanaraman
Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium moiety to a pharmacophore of interest. Other delocalized lipophilic cations, such as rhodamine, natural and synthetic mitochondria-targeting peptides, and nanoparticle vehicles, have also been used for mitochondrial delivery of small molecules...
June 27, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28654019/preventive-effect-of-cow-s-milk-fermented-with-lactobacillus-paracasei-cba-l74-on-common-infectious-diseases-in-children-a-multicenter-randomized-controlled-trial
#12
Giovanni Corsello, Maurizio Carta, Roberto Marinello, Marina Picca, Giulio De Marco, Maria Micillo, Dante Ferrara, Patrizia Vigneri, Gaetano Cecere, Pasqualina Ferri, Paola Roggero, Giorgio Bedogni, Fabio Mosca, Lorella Paparo, Rita Nocerino, Roberto Berni Canani
Background: Fermented foods have been proposed to prevent common infectious diseases (CIDs) in children attending day care or preschool. OBJECTIVES: To investigate the efficacy of dietary supplementation with cow's skim milk fermented with the probiotic Lactobacillus paracasei CBA L74 in reducing CIDs in children attending day care or preschool. Methods: Multicenter, randomized, double-blind, placebo-controlled trial on healthy children (aged 12-48 months) consuming daily 7 grams of cow's skim milk fermented with L...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28653499/exercise-s-effect-on-mobility-disability-in-older-adults-with-and-without-obesity-the-life-study-randomized-clinical-trial
#13
Stephen B Kritchevsky, Laura Lovato, Elizabeth P Handing, Steven Blair, Anda Botoseneanu, Jack M Guralnik, Christine Liu, Abby King, Anthony P Marsh, Marco Pahor, W Jack Rejeski, Bonnie Spring, Todd Manini
OBJECTIVE: Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program. METHODS: MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2...
July 2017: Obesity
https://www.readbyqxmd.com/read/28653366/method-and-excel-vba-algorithm-for-modeling-master-recession-curve-using-trigonometry-approach
#14
Kristijan Posavec, Marco Giacopetti, Marco Materazzi, Steffen Birk
A new method was developed and implemented into an Excel Visual Basic for Applications (VBAs) algorithm utilizing trigonometry laws in an innovative way to overlap recession segments of time series and create master recession curves (MRCs). Based on a trigonometry approach, the algorithm horizontally translates succeeding recession segments of time series, placing their vertex, that is, the highest recorded value of each recession segment, directly onto the appropriate connection line defined by measurement points of a preceding recession segment...
June 26, 2017: Ground Water
https://www.readbyqxmd.com/read/28653293/erratum-to-numerical-modelling-of-femur-fracture-and-experimental-validation-using-bone-simulant
#15
Miguel Marco, Eugenio Giner, Ricardo Larraínzar-Garijo, José Ramón Caeiro, María Henar Miguélez
No abstract text is available yet for this article.
June 26, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28653246/allergy-and-sexual-behaviours-an-update
#16
REVIEW
Marco Caminati, Veronica Giorgis, Boaz Palterer, Francesca Racca, Chiara Salvottini, Oliviero Rossi
The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients...
June 26, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28653055/the-application-of-rapid-prototyping-to-improve-bone-reconstruction-in-immediate-dentoalveolar-restoration-a-case-report
#17
José Carlos Martins da Rosa, Marcos Alexandre Fadanelli, Diego Zimmerman, Ariádene Cristina Pértile de Oliveira Rosa
PURPOSE: This article describes the use of rapid prototyping (RP) for diagnosis, planning, and execution of the reconstruction of hard and soft tissue in socket defects using immediate dentoalveolar restoration (IDR). SUMMARY: In cases of tissue loss in anterior dental areas, esthetic rehabilitation poses a major challenge with respect to treatment planning with the goal of long-term tissue maintenance. The IDR technique consists of immediate reconstruction in a single procedure of bone and soft tissue around implants placed immediately after extraction, and prosthetic rehabilitation...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28653051/posterior-indirect-adhesive-%C3%A2-restorations-updated-indications-%C3%A2-and-the-morphology-driven-%C3%A2-preparation-technique
#18
Marco Veneziani
The aim of this article is to identify the indications for adhesively cemented restorations and to provide a correct step-by-step protocol for clinicians. New cavity preparation principles are based on morphological considerations in terms of geometry (maximum profile line and inclination of cusp lines), and structure (dentin concavity and enamel convexity). In this article, we discuss previous preparation concepts that were not designed purely for adhesive restorations and were therefore not conservative enough or suitable for adhesive procedures...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28653048/porcelain-veneer-post-bonding-crack-repair-by-resin-infiltration
#19
Marco Gresnigt, Michel Magne, Pascal Magne
Ceramic laminate veneer restorations are indicated in several clinical situations. Indirect restorations are usually chosen if the less-invasive options - bleaching, resin infiltration, or composite resin restorations - are not possible, or when it is too difficult to achieve an esthetically pleasing result in the long term. Bonded indirect partial restorations are highly dependent on their adhesive interface, as these thin restorations have a relatively low cohesive strength. Therefore, preservation of sound enamel, conditioning of the restorations and of the substrate, and luting procedures are of paramount importance for a successful outcome...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28652629/-observant-ii-observational-study-of-effectiveness-of-transcatheter-aortic-valve-implantation-with-new-generation-devices-for-severe-aortic-stenosis-treatment-study-protocol
#20
Fulvia Seccareccia, Giuseppe Tarantini, Francesco Bedogni, Sergio Berti, Gennaro Santoro, Corrado Tamburino, Gian Paolo Ussia, Marco Barbanti, Massimo Baiocchi, Marco Ranucci, Paola D'Errigo, Stefano Rosato, Giuseppe Musumeci
BACKGROUND: The rapid spread of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis in the last decade in Italy has led to a gradually increasing use of TAVI procedures also in patients potentially eligible for aortic valve replacement (AVR). For this subset of patients, the OBSERVANT study (2011-2012) evaluated the short- and medium term outcome of TAVI vs AVR, at least for the first generations of TAVI devices, but failed to gather information on all the technological innovations occurred in recent years...
June 2017: Giornale Italiano di Cardiologia
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