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https://www.readbyqxmd.com/read/29166757/hybrid-imaging-of-musculoskeletal-infections
#1
Andor W Glaudemans, Napoleone Prandini, Marco DI Girolamo, Giuseppe Argento, Chiara Lauri, Elena Lazzeri, Mario Muto, Luca M Sconfienza, Alberto Signore
This review article highlights the role of radiological and nuclear medicine techniques in diagnosis of musculoskeletal infections with particular regard to hybrid imaging of osteomyelitis, prosthetic joint infections, sternal infections and spine infections. Authors conclude on the complementary role of the several techniques with indications for an appropriate diagnostic flow chart, in the light of the recent EANM guidelines on infection.
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166602/mucus-detachment-by-host-metalloprotease-meprin-%C3%AE-requires-shedding-of-its-inactive-pro-form-which-is-abrogated-by-the-pathogenic-protease-rgpb
#2
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C Hansson, Peter J Dempsey, Christoph Becker-Pauly
The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelial cells. Hence, regulation of meprin β shedding and activation is important for physiological and pathophysiological conditions. Here, we demonstrate that meprin β activation and shedding are mutually exclusive events. Employing ex vivo small intestinal organoid and cell culture experiments, we found that ADAM-mediated shedding is restricted to the inactive pro-form of meprin β and is completely inhibited upon its conversion to the active form at the cell surface...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166551/evaluation-of-markers-out-of-the-steroid-profile-for-the-screening-of-testosterone-misuse-part-ii-intramuscular-administration
#3
Aristotelis Kotronoulas, Àlex Gomez-Gómez, Andreu Fabregat, Jordi Segura, Sheng Yang, Yanyi Xing, Wu Moutian, Josep Marcos, Jesús Joglar, Rosa Ventura, Oscar J Pozo
In the fight against doping, the introduction of alternative markers to the steroid profile can be considered as an effective approach to improve the screening capabilities for the detection of testosterone (T) misuse. The aim of this study was to evaluate the potential of several T metabolites (cysteinyl conjugated and glucuronoconjugated resistant to enzymatic hydrolysis) to detect both the transdermal and the intramuscular administration of T. In a first part of the study, we studied the potential of these metabolites for the detection of T transdermal administration...
November 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29166469/charles-miller-fisher-the-65th-anniversary-of-the-publication-of-his-groundbreaking-study-transient-monocular-blindness-associated-with-hemiplegia
#4
Tiago Fernando Souza de Araújo, Marcos Lange, Viviane H Zétola, Ayrton Massaro, Hélio A G Teive
Charles Miller Fisher is considered the father of modern vascular neurology and one of the giants of neurology in the 20th century. This historical review emphasizes Prof. Fisher's magnificent contribution to vascular neurology and celebrates the 65th anniversary of the publication of his groundbreaking study, "Transient Monocular Blindness Associated with Hemiplegia."
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166462/effects-of-an-alternating-work-shift-on-air-traffic-controllers-and-the-relationship-with-excessive-daytime-sleepiness-and-stress
#5
Ângela M Freitas, Mirna Wetters Portuguez, Thaís Russomano, Marcos de Freitas, Silvio Luis da Silva Silvello, Jaderson Costa da Costa
OBJECTIVE: To evaluate symptoms of stress and excessive daytime sleepiness (EDS) in air traffic control (ATC) officers in Brazil. METHODS: Fifty-two ATC officers participated, based at three air traffic control units, identified as A, B and C. Stress symptoms were assessed using the Lipp Inventory of Stress Symptoms for Adults, and EDS by the Epworth Sleepiness Scale. RESULTS: The sample mean age was 37 years, 76.9% of whom were male. Excessive daytime sleepiness was identified in 25% of the ATC officers, with 84...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166086/focused-conformational-sampling-in-proteins
#6
Marco Bacci, Cassiano Langini, Jiří Vymětal, Amedeo Caflisch, Andreas Vitalis
A detailed understanding of the conformational dynamics of biological molecules is difficult to obtain by experimental techniques due to resolution limitations in both time and space. Computer simulations avoid these in theory but are often too short to sample rare events reliably. Here we show that the progress index-guided sampling (PIGS) protocol can be used to enhance the sampling of rare events in selected parts of biomolecules without perturbing the remainder of the system. The method is very easy to use as it only requires as essential input a set of several features representing the parts of interest sufficiently...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166085/confirming-the-relationship-between-first-hyperpolarizability-and-the-bond-length-alternation-coordinate-for-merocyanine-dyes
#7
Idney Brandão, Leandro R Franco, Tertius L Fonseca, Marcos A Castro, Herbert C Georg
We investigated the first electronic hyperpolarizability of a typical merocyanine dye in several solvents in a wide range of dielectric constants. The equilibrium geometry of the molecule was obtained in each solvent by employing an optimization technique allied to atomistic simulations. The results confirm, for the first time with a realistic model of the molecular environment, the relationship between the first electronic hyperpolarizability (β) and the bond length alternation (BLA) coordinate, with a maximum value of β for intermediate positive BLA and a vanishing β when the BLA goes to zero...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166043/comment-on-temperature-fluctuations-and-the-thermodynamic-determination-of-the-cooperativity-length-in-glass-forming-liquids-j-chem-phys-146-104501-2017
#8
Andrea Alessandrini, Marco Pieruccini, Elpidio Tombari
No abstract text is available yet for this article.
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166014/probing-the-surface-of-platinum-during-the-hydrogen-evolution-reaction-in-alkaline-electrolyte
#9
Kelsey A Stoerzinger, Marco Favaro, Philip N Ross, Junko Yano, Zhi Liu, Zahid Hussain, Ethan J Crumlin
Understanding the surface chemistry of electrocatalysts in operando can bring insight into the reaction mechanism, and ultimately the design of more efficient materials for sustainable energy storage and conversion. Recent progress in synchrotron based X-ray spectroscopies for in operando characterization allows us to probe the solid/liquid interface directly while applying an external potential, applied here to the model system of Pt in alkaline electrolyte for the hydrogen evolution reaction (HER). We employ ambient pressure X-ray photoelectron spectroscopy (AP-XPS) to identify the oxidation and reduction of Pt-oxides and hydroxides on the surface as a function of applied potential, and further assess the potential for hydrogen adsorption and absorption (hydride formation) during and after the HER...
November 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29165917/a-novel-multisite-confocal-system-for-rapid-ca-2-imaging-from-submicron-structures-in-brain-slices
#10
Luiza Filipis, Karima Ait Ouares, Philippe Moreau, Dimitrii Tanese, Valeria Zampini, Andrea Latini, Chun Bleau, Charlie Bleau, Jeremy Graham, Marco Canepari
In brain slices, resolving fast Ca(2+) fluorescence signals from submicron structures is typically achieved using two-photon or confocal scanning microscopy, an approach that limits the number of scanned points. The novel multiplexing confocal system presented here overcomes this limitation. This system is based on a fast spinning disk, a multimode diode laser and a novel high-resolution CMOS camera. The spinning disk, running at 20,000 rpm, has custom-designed spiral pattern that maximises light collection while rejecting out-of-focus fluorescence to resolve signals from small neuronal compartments...
November 22, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29165708/separase-prevents-genomic-instability-by-controlling-replication-fork-speed
#11
Francesco Cucco, Elisa Palumbo, Serena Camerini, Barbara D'Alessio, Valentina Quarantotti, Maria Luisa Casella, Ilaria Maria Rizzo, Dubravka Cukrov, Domenico Delia, Antonella Russo, Marco Crescenzi, Antonio Musio
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin complex, allowing the dissolution of sister chromatid cohesion. Here we provide evidence that Separase participates in genomic stability maintenance by controlling replication fork speed. We found that Separase interacted with the replication licensing factors MCM2-7, and genome-wide data showed that Separase co-localized with MCM complex and cohesin...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165643/expanding-the-repertoire-of-dna-shape-features-for-genome-scale-studies-of-transcription-factor-binding
#12
Jinsen Li, Jared M Sagendorf, Tsu-Pei Chiu, Marco Pasi, Alberto Perez, Remo Rohs
Uncovering the mechanisms that affect the binding specificity of transcription factors (TFs) is critical for understanding the principles of gene regulation. Although sequence-based models have been used successfully to predict TF binding specificities, we found that including DNA shape information in these models improved their accuracy and interpretability. Previously, we developed a method for modeling DNA binding specificities based on DNA shape features extracted from Monte Carlo (MC) simulations. Prediction accuracies of our models, however, have not yet been compared to accuracies of models incorporating DNA shape information extracted from X-ray crystallography (XRC) data or Molecular Dynamics (MD) simulations...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165618/human-specific-mutations-and-positively-selected-sites-in-marco-confer-functional-changes
#13
Kyle E Novakowski, Nicholas V L Yap, Charles Yin, Kaori Sakamoto, Bryan Heit, G Brian Golding, Dawn M E Bowdish
Macrophage Receptor with COllagenous structure (MARCO) is a class A scavenger receptor that binds, phagocytoses, and modifies inflammatory responses to bacterial pathogens. Multiple candidate gene approach studies have shown that polymorphisms in MARCO are associated with susceptibility or resistance to Mycobacterium tuberculosis infection, but how these variants alter function is not known. To complement candidate gene approach studies, we previously used phylogenetic analyses to identify a residue, glutamine 452 (Q452), within the ligand-binding Scavenger Receptor Cysteine Rich (SRCR) domain as undergoing positive selection in humans...
November 20, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29165379/role-of-non-coding-rnas-in-the-etiology-of-bladder-cancer
#14
REVIEW
Caterina Gulìa, Stefano Baldassarra, Fabrizio Signore, Giuliano Rigon, Valerio Pizzuti, Marco Gaffi, Vito Briganti, Alessandro Porrello, Roberto Piergentili
According to data of the International Agency for Research on Cancer and the World Health Organization (Cancer Incidence in Five Continents, GLOBOCAN, and the World Health Organization Mortality), bladder is among the top ten body locations of cancer globally, with the highest incidence rates reported in Southern and Western Europe, North America, Northern Africa and Western Asia. Males (M) are more vulnerable to this disease than females (F), despite ample frequency variations in different countries, with a M:F ratio of 4...
November 22, 2017: Genes
https://www.readbyqxmd.com/read/29165322/treatment-planning-with-intensity-modulated-particle-therapy-for-multiple-targets-in-stage-iv-non-small-cell-lung-cancer
#15
Kristjan Anderle, Joep Stroom, Sandra Vieira, Nuno Pimentel, Carlo Greco, Marco Durante, Christian Graeff
Intensity modulated particle therapy (IMPT) can produce highly conformal plans, but is limited in advanced lung cancer patients with multiple lesions due to motion and planning complexity. A 4D IMPT optimization including all motion states was expanded to include multiple targets, where each target (isocenter) is designated to specific field(s). Furthermore, to achieve stereotactic treatment planning objectives, target and OAR weights plus objective doses were automatically iteratively adapted. Finally, 4D doses were calculated for different motion scenarios...
November 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29165305/abdominal-actinomycetoma-with-double-aetiology-due-to-nocardia-brasiliensis-and-actinomadura-madurae
#16
Alexandro Bonifaz, María Del Carmen Padilla, Denisse Vázquez-González, Marco A Hernández, Mariana Saldaña, Rigoberto Hernández-Castro, Andrés Tirado-Sánchez
No abstract text is available yet for this article.
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29165074/state-of-the-art-of-dental-adhesive-systems
#17
Jefferson Ricardo Pereira, Saulo Pamato, Marcos Vargas, Newton Fahl
BACKGROUND: The large dependence on a dental substrate type to bond strength has leveraged the research on materials and techniques that perform different clinical behavior, promoting a stable bonding over time. Bonding to tooth structure has different clinical behaviors and is dependent on several factors. OBJECTIVE: The aim of this paper is to reflect on the state of the art of adhesive systems since Buonocore's experiments to current days. METHODS: An electronic search was conducted on PubMed databases and supplemented with a manual study of relevant references...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29165046/phytophthora-parasitica-effector-pprxlr2-suppresses-nicotiana-benthamiana-immunity
#18
Ronaldo J D Dalio, Heros José Máximo, Tiago Silva Oliveira, Renata Dias, Michele Breton, Henrique Leme Felizatti, Marcos Antonio Antonio Machado
Phytophthora species secrete several classes of effector proteins during interaction with their hosts. These proteins can have multiple functions including modulation of host physiology and immunity. The RxLR effectors have the ability to enter plant cells using the plant machinery. Some of these effectors have been characterized as immunity suppressors; however, very little is known about their functions in the interaction between Phytophthora parasitica and its hosts. Using a bioinformatics pipeline, we have identified 172 candidate RxLR effectors (CREs) in the isolate IAC 01_95 of P...
November 22, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29165030/in-mammalian-skeletal-muscle-phosphorylation-of-tomm22-by-protein-kinase-csnk2-ck2-controls-mitophagy
#19
Bojana Kravic, Angelika B Harbauer, Vanina Romanello, Luca Simeone, F-Nora Vögtle, Tobias Kaiser, Marion Straubinger, Danyil Huraskin, Martin Böttcher, Cristina Cerqua, Eva Denise Martin, Daniel Poveda-Huertes, Andreas Buttgereit, Adam J Rabalski, Dieter Heuss, Rüdiger Rudolf, Oliver Friedrich, David Litchfield, Michael Marber, Leonardo Salviati, Dimitrios Mougiakakos, Winfried Neuhuber, Marco Sandri, Chris Meisinger, Said Hashemolhosseini
In yeast, Tom22 the central component of the TOMM (translocase of outer mitochondrial membrane) receptor complex is responsible for the recognition and translocation of synthesized mitochondrial precursor proteins, and its protein kinase CK2-dependent phosphorylation is mandatory for TOMM complex biogenesis and proper mitochondrial protein import. In mammals, the biological function of protein kinase CSNK2/CK2 remains vastly elusive and it is unknown whether CSNK2-dependent phosphorylation of TOMM protein subunits has a similar role as that in yeast...
November 22, 2017: Autophagy
https://www.readbyqxmd.com/read/29165008/building-upon-the-success-of-cart19-chimeric-antigen-receptor-t-cells-for-hematologic-malignancies
#20
Antonia Rotolo, Anastasios Karadimitris, Marco Ruella
Chimeric antigen receptor T cell (CART) therapy has dramatically changed the therapeutic prospects for B cell malignancies. Over the last decade CD19-redirected CART have demonstrated the ability to induce deep, long-lasting remissions and possibly cure patients with relapsing B cell neoplasms. Such impressive results with CART19 fostered efforts to expand this technology to other incurable malignancies that naturally do not express CD19, such as acute myeloid leukemia (AML), Hodgkin lymphoma (HL) and multiple myeloma (MM)...
November 22, 2017: Leukemia & Lymphoma
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