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https://www.readbyqxmd.com/read/28340494/postoperative-care-of-patients-with-high-grade-glioma-is-there-a-real-need-for-the-neurocritical-icu-and-early-ct-scan
#1
Roberto Altieri, Fabio Cofano, Alessandro Agnoletti, Riccardo Fornaro, Marco Ajello, Francesco Zenga, Alessandro Ducati, Diego Garbossa
Background Pressure on economic resources now requires a careful rationalization of services. For adult patients with supratentorial gliomas, there is no consensus on the real need for care in a postoperative neurocritical intensive care unit (NICU) and on the timing of a postsurgical computed tomography (CT) scan. In this retrospective nonrandomized study, we assessed if and when there is a real need for NICU and if an early CT scan could be justified in the absence of neurologic worsening. Methods Of 264 patients, 21 were admitted to the NICU after the procedure as planned before the surgery for their clinical features (Karnofsky performance status < 70, American Society of Anesthesiologists score > 2, or Charlson Comorbidity Index > 5)...
March 24, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28340473/enantiomers-of-triclabendazole-sulfoxide-analytical-and-semipreparative-hplc-separation-absolute-configuration-assignment-and-transformation-into-sodium-salt
#2
Rosella Ferretti, Simone Carradori, Paolo Guglielmi, Marco Pierini, Adriano Casulli, Roberto Cirilli
Direct HPLC separation of the enantiomers of triclabendazole sulfoxide (TCBZ-SO), which is the main metabolite of the anthelmintic drug triclabendazole, was carried out using the polysaccharide-based Chiralpak AS-H and Chiralpak IF-3 chiral stationary phases (CSPs). The chromatographic behaviour of both CSPs was evaluated and compared using normal-phase and reversed-phase eluents at different column temperatures. The eluent mixture of n-hexane-2-propanol-trifluoroacetic acid 70:30:0.1 (v/v/v) and a column temperature of 40°C were identified as the best operational conditions to carry out semipreparative enantioseparations on a 1-cm I...
March 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28340394/assessment-of-engineered-surfaces-roughness-by-high-resolution-3d-sem-photogrammetry
#3
L C Gontard, J D López-Castro, L González-Rovira, J M Vázquez-Martínez, F M Varela-Feria, M Marcos, J J Calvino
We describe a methodology to obtain three-dimensional models of engineered surfaces using scanning electron microscopy and multi-view photogrammetry (3DSEM). For the reconstruction of the 3D models of the surfaces we used freeware available in the cloud. The method was applied to study the surface roughness of metallic samples patterned with parallel grooves by means of laser. The results are compared with measurements obtained using stylus profilometry (PR) and SEM stereo-photogrammetry (SP). The application of 3DSEM is more time demanding than PR or SP, but it provides a more accurate representation of the surfaces...
March 7, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28340140/lipidomic-profiling-of-endometrial-fluid-in-women-with-ovarian-endometriosis
#4
Francisco Domínguez, Marcos Ferrando, Patricia Díaz-Gimeno, Fernando Quintana, Gemma Fernández, Inés Castells, Carlos Simón
The proteomic content of the endometrial fluid from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail. This study is a comparative untargeted lipidomic analysis of human endometrial fluid obtained from thirty-five patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography (UPLC) coupled to mass spectrometry (MS). 123 out of the 457 metabolites identified in the endometrial fluid were found to be significantly differentially expressed between ovarian endometriosis versus controls...
March 18, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28340112/long-term-mortality-of-patients-with-an-alcohol-related-wernicke-korsakoff-syndrome
#5
Arantza Sanvisens, Paola Zuluaga, Daniel Fuster, Inmaculada Rivas, Jordi Tor, Miguel Marcos, Antonio J Chamorro, Roberto Muga
Aims: To characterize a series of contemporary patients with alcohol-related Wernicke's encephalopathy (WE) or Korsakoff's syndrome (KS) and to update the current prognosis of disease. Methods: Retrospective and prospective study of patients diagnosed with an alcohol-related WE or KS between 2002 and 2011 in a tertiary hospital. Socio-demographic, alcohol use characteristics, signs and symptoms, co-morbidity and blood parameters were obtained at admission. Patients were followed up until 2013 and causes of death were ascertained through the review of charts...
March 10, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28340043/very-long-term-outcome-following-transcatheter-ablation-of-atrial-fibrillation-are-results-maintained-after-10-years-of-follow-up
#6
Fiorenzo Gaita, Marco Scaglione, Alberto Battaglia, Mario Matta, Cristina Gallo, Michela Galatà, Domenico Caponi, Paolo Di Donna, Matteo Anselmino
Aims: Atrial fibrillation (AF) transcatheter ablation is a safe and effective procedure. However, outcome over 10 years of follow-up has never been reported. The aim of this study is to assess outcome, describe predictors of recurrences, and report on quality of life (QoL) the decade after an AF ablation. Methods and results: Patients referred for AF ablation in a single high volume centre from June 2004 to June 2006 were enrolled and followed in a prospective fashion by yearly clinical assessment and Holter monitoring...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339963/anti-apoptotic-effects-of-decyl-gallate-on-the-induction-of-apoptosis-in-a549-pneumocytes-by-paracoccidioides-brasiliensis-gp43
#7
Thais Bernardi, Julhiany de Fátima da Silva, Juliana Vicentin, Haroldo Cesar de Oliveira, Patricia Akemi Assato, Caroline Maria Marcos, Ana Carolina Alves de Paula E Silva, Rosangela Aparecida Moraes da Silva, Luis Octávio Regasini, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Apoptosis is considered an escape mechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties...
March 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28339716/prevalence-antimicrobial-resistance-and-genetic-diversity-of-campylobacter-coli-and-campylobacter-jejuni-in-ecuadorian-broilers-at-slaughter-age
#8
Christian Vinueza-Burgos, Magali Wautier, Delphine Martiny, Marco Cisneros, Inge Van Damme, Lieven De Zutter
Thermotolerant Campylobacter spp. are a major cause of foodborne gastrointestinal infections worldwide. The linkage of human campylobacteriosis and poultry has been widely described. In this study we aimed to investigate the prevalence, antimicrobial resistance and genetic diversity of C. coli and C. jejuni in broilers from Ecuador. Caecal content from 379 randomly selected broiler batches originating from 115 farms were collected from 6 slaughterhouses located in the province of Pichincha during 1 year. Microbiological isolation was performed by direct plating on mCCDA agar...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339378/stability-of-allopurinol-amitriptyline-hydrochloride-carbamazepine-domperidone-isoniazid-ketoconazole-lisinopril-naproxen-paracetamol-acetaminophen-and-sertraline-hydrochloride-in-syrspend-sf-ph4-oral-suspensions
#9
Hudson C Polonini, Sharlene Loures, Edson Peter de Araujo, Marcos Antônio F Brandão, Anderson O Ferreira
Oral liquids are safe alternatives to solid dosage forms, notably for elderly and pediatric patients that present dysphagia. The use of ready-to-use suspending vehicles such as SyrSpend SF PH4 is a suitable resource for pharmacists as they constitute a safe and timesaving option that has been studied often. The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients (allopurinol 20 mg/mL; amitriptyline hydrochloride 10 mg/mL; carbamazepine 25 mg/mL; domperidone 5 mg/mL; isoniazid 10 mg/mL; ketoconazole 20 mg/mL; lisinopril 1 mg/mL; naproxen 25 mg/mL; paracetamol [acetaminophen] 50 mg/mL; and sertraline hydrochloride 10 mg/mL) compounded in oral suspensions using SyrSpend SF PH4 as the vehicle throughout the study period and stored both at controlled refrigerated (2°C to 8°C) and room temperature (20°C to 25°C)...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339360/critical-role-of-stir-mri-in-early-detection-of-post-streptococcal-periostitis-with-dysproteinaemia-goldbloom-s-syndrome
#10
Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English. METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339348/geological-occurrence-mineralogical-characterization-and-risk-assessment-of-potentially-carcinogenic-erionite-in-italy
#11
Matteo Giordani, Michele Mattioli, Paolo Ballirano, Alessandro Pacella, Marco Cenni, Matteo Boscardin, Laura Valentini
Erionite is a zeolite representing a well-known health hazard. In fact, exposure of humans to its fibers has been unequivocally associated with occurrence of malignant mesothelioma. For this reason, a multi-methodological approach, based upon field investigation, morphological characterization, scanning electron microscopy (SEM)/energy-dispersive spectroscopy (EDS) chemical analysis, and structure refinement through X-ray powder diffraction (XRPD), was applied to different samples of potentially carcinogenic erionite from Northern Italy...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28335493/melatonin-mt%C3%A2-and-mt%C3%A2-receptors-in-the-ram-reproductive-tract
#12
Marta González-Arto, David Aguilar, Elena Gaspar-Torrubia, Margarita Gallego, Melissa Carvajal-Serna, Luis V Herrera-Marcos, Edith Serrano-Blesa, Thais Rose Dos Santos Hamilton, Rosaura Pérez-Pé, Teresa Muiño-Blanco, José A Cebrián-Pérez, Adriana Casao
Some melatonin functions in mammals are exerted through MT₁ and MT₂ receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the testis, ampulla, seminal vesicles, and vas deferens, than in the other organs of the reproductive tract (p < 0...
March 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335280/pregnancy-vaccination-with-gold-glyco-nanoparticles-carrying-listeria-monocytogenes-peptides-protects-against-listeriosis-and-brain-and-cutaneous-associated-morbidities
#13
Ricardo Calderón-Gonzalez, Héctor Terán-Navarro, Elisabet Frande-Cabanes, Eva Ferrández-Fernández, Javier Freire, Soledad Penadés, Marco Marradi, Isabel García, Javier Gomez-Román, Sonsoles Yañez-Díaz, Carmen Álvarez-Domínguez
Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91-99 (LLO91-99) or glyceraldehyde-3-phosphate dehydrogenase 1-22 peptide (GAPDH1-22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes...
August 19, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335278/recent-prospects-in-the-inline-monitoring-of-nanocomposites-and-nanocoatings-by-optical-technologies
#14
REVIEW
Elodie Bugnicourt, Timothy Kehoe, Marcos Latorre, Cristina Serrano, Séverine Philippe, Markus Schmid
Nanostructured materials have emerged as a key research field in order to confer materials with unique or enhanced properties. The performance of nanocomposites depends on a number of parameters, but the suitable dispersion of nanoparticles remains the key in order to obtain the full nanocomposites' potential in terms of, e.g., flame retardance, mechanical, barrier, thermal properties, etc. Likewise, the performance of nanocoatings to obtain, for example, tailored surface affinity with selected liquids (e.g...
August 19, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335251/nanostructured-tio%C3%A2-surfaces-promote-human-bone-marrow-mesenchymal-stem-cells-differentiation-to-osteoblasts
#15
Marco Vercellino, Gabriele Ceccarelli, Francesco Cristofaro, Martina Balli, Federico Bertoglio, Gianna Bruni, Laura Benedetti, Maria Antonietta Avanzini, Marcello Imbriani, Livia Visai
Micro- and nano-patterning/modification are emerging strategies to improve surfaces properties that may influence critically cells adherence and differentiation. Aim of this work was to study the in vitro biological reactivity of human bone marrow mesenchymal stem cells (hBMSCs) to a nanostructured titanium dioxide (TiO₂) surface in comparison to a coverglass (Glass) in two different culture conditions: with (osteogenic medium (OM)) and without (proliferative medium (PM)) osteogenic factors. To evaluate cell adhesion, hBMSCs phosphorylated focal adhesion kinase (pFAK) foci were analyzed by confocal laser scanning microscopy (CLSM) at 24 h: the TiO₂ surface showed a higher number of pFAK foci with respect to Glass...
June 24, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335213/biosynthesis-of-metal-nanoparticles-novel-efficient-heterogeneous-nanocatalysts
#16
REVIEW
Jose M Palomo, Marco Filice
This review compiles the most recent advances described in literature on the preparation of noble metal nanoparticles induced by biological entities. The use of different free or substituted carbohydrates, peptides, proteins, microorganisms or plants have been successfully applied as a new green concept in the development of innovative strategies to prepare these nanoparticles as different nanostructures with different forms and sizes. As a second part of this review, the application of their synthetic ability as new heterogonous catalysts has been described in C-C bond-forming reactions (as Suzuki, Heck, cycloaddition or multicomponent), oxidations and dynamic kinetic resolutions...
May 5, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335194/automatic-echographic-detection-of-halloysite-clay-nanotubes-in-a-low-concentration-range
#17
Francesco Conversano, Paola Pisani, Ernesto Casciaro, Marco Di Paola, Stefano Leporatti, Roberto Franchini, Alessandra Quarta, Giuseppe Gigli, Sergio Casciaro
Aim of this work was to investigate the automatic echographic detection of an experimental drug delivery agent, halloysite clay nanotubes (HNTs), by employing an innovative method based on advanced spectral analysis of the corresponding "raw" radiofrequency backscatter signals. Different HNT concentrations in a low range (5.5-66 × 10(10) part/mL, equivalent to 0.25-3.00 mg/mL) were dispersed in custom-designed tissue-mimicking phantoms and imaged through a clinically-available echographic device at a conventional ultrasound diagnostic frequency (10 MHz)...
April 11, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335146/comparison-of-open-and-endovascular-surgery-for-the-treatment-of-the-infections-of-the-thoracic-aorta
#18
Yamume Tshomba, Marco Leopardi, Andrea Kahlberg, Daniele Mascia, Domenico Baccellieri, Germano Melissano, Roberto Chiesa
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335133/aneurysms-of-the-thoraco-abdominal-aorta-a-comparison-with-propensity-score-between-endovascular-repair-and-open-surgery
#19
Yamume Tshomba, Marco Leopardi, Ciro Ferrer, Piergiorgio Cao, Paola De Rango, Fabio Verzini, Germano Melissano, Carlo Coscarella, Roberto Chiesa
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335084/identification-of-new-bmp6-pro-peptide-mutations-in-patients-with-iron-overload
#20
Chiara Piubelli, Annalisa Castagna, Giacomo Marchi, Monica Rizzi, Fabiana Busti, Sadaf Badar, Monia Marchetti, Marco De Gobbi, Antonella Roetto, Luciano Xumerle, Eda Suku, Alejandro Giorgetti, Massimo Delledonne, Oliviero Olivieri, Domenico Girelli
Hereditary Hemochromatosis (HH) is a genetically heterogeneous disorder caused by mutations in at least 5 different genes (HFE, HJV, TFR2, SLC40A1, HAMP) involved in the production or activity of the liver hormone hepcidin, a key regulator of systemic iron homeostasis. Nevertheless, patients with an HH-like phenotype that remains completely/partially unexplained despite extensive sequencing of known genes are not infrequently seen at referral centers, suggesting a role of still unknown genetic factors. A compelling candidate is Bone Morphogenetic Protein 6 (BMP6), which acts as a major activator of the BMP-SMAD signaling pathway, ultimately leading to the upregulation of hepcidin gene transcription...
March 23, 2017: American Journal of Hematology
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