Yu Chen, Shiqi Huang, Zhen Cui, Xiaoxiang Sun, Yansong Tang, Hongjie Zhang, Zhixi Chen, Rui Jiang, Weina Zhang, Xue Li, Jiayu Chen, Baohua Liu, Ying Jiang, Ke Wei, Zhiyong Mao
Patients with Hutchinson-Gilford progeria syndrome (HGPS) present with a number of premature aging phenotypes, including DNA damage accumulation, and many of them die of cardiovascular complications. Although vascular pathologies have been reported, whether HGPS patients exhibit cardiac dysfunction and its underlying mechanism is unclear, rendering limited options for treating HGPS-related cardiomyopathy. In this study, we reported a cardiac atrophy phenotype in the Lmna G609G/G609G mice (hereafter, HGPS mice)...
November 21, 2023: Proceedings of the National Academy of Sciences of the United States of America