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https://www.readbyqxmd.com/read/28641223/paternal-bisphenol-a-diet-changes-prefrontal-cortex-proteome-and-provokes-behavioral-dysfunction-in-male-offspring
#1
Guangying Luo, Ruifen Wei, Shaolin Wang, Jundong Wang
Relatively little attention has been given paternal effects on next generation. Given that Bisphenol A (BPA), a ubiquitous compound in maternal diet, may disrupt brain development and behavior, we hypothesized that paternal BPA diet (PBD) could affect offspring development. Prefrontal cortex (PFC), a vital brain region, is involved in emotion and social behavior. To test whether PBD could alter developing PFC, we carried out a proteomics approach for PFC in male juvenile offspring that responded to PBD (50 mg BPA/kg diet)...
June 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28641218/on-the-overlap-of-vital-exhaustion-and-depression
#2
EDITORIAL
R Bianchi, I S Schonfeld, E Laurent
No abstract text is available yet for this article.
April 28, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28641046/exploring-the-health-needs-of-aging-lgbt-adults-in-the-cape-fear-region-of-north-carolina
#3
Noell L Rowan, Kelsey Beyer
This study explored issues of culturally sensitive health care practice and needs among lesbian, gay, bisexual and transgender aging adults in coastal North Carolina. Survey data from 2013 to 2015 were analyzed using frequencies and logistic regression on concerns with culturally sensitive health needs for the LGBT aging adult population. Results indicated that the largest problem was a history of being verbally harassed (n = 115; 51.57%) and a need for more culturally sensitive health care provisions. A large majority of participants requested an improvement in offering of LGBT specific social activities (n = 149), recreational activities (n = 116), and art and cultural activities (n = 112)...
June 22, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28640728/wound-bed-preparation-a-vital-step-in-the-healing-process
#4
Simon Barrett
Non-healing wounds are a significant burden to healthcare systems, where it is estimated that 4-5% of the adult population has a problem wound at any one time ( Guest et al, 2017 ). It is suggested that infection is the most frequent complication in non-healing wounds where it can prolong patient treatment times and increase resource use ( Gottrup et al, 2013 ). Wound infection develops as a result of an imbalance between the patient's immune system and the conditions in the wound, which subsequently can promote bacterial proliferation ( Wounds UK, 2013 )...
June 22, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28637207/the-use-of-semitranslucent-rubber-pledgets-during-microsurgical-dissection-of-cerebellopontine-angle-tumors-technical-note
#5
Marcus D Mazur, Richard Gurgel, Joel D MacDonald
BACKGROUND AND IMPORTANCE: Dissection of cerebellopontine angle (CPA) tumors that abut or adhere to the brainstem or cranial nerves can be a challenging surgical endeavor. We describe the use of semitranslucent latex rubber pledgets in the tumor-brain interface as a method to improve visualization and protection of vital tissue during microsurgical dissection of CPA masses. The rubber pledgets are fashioned by cutting circular discs out of the cuff portion of talc-free, partially opaque latex gloves...
June 20, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28637180/participatory-design-of-probability-based-decision-support-tools-for-in-hospital-nurses
#6
Alvin D Jeffery, Laurie L Novak, Betsy Kennedy, Mary S Dietrich, Lorraine C Mion
Objective: To describe nurses' preferences for the design of a probability-based clinical decision support (PB-CDS) tool for in-hospital clinical deterioration. Methods: A convenience sample of bedside nurses, charge nurses, and rapid response nurses ( n  = 20) from adult and pediatric hospitals completed participatory design sessions with researchers in a simulation laboratory to elicit preferred design considerations for a PB-CDS tool. Following theme-based content analysis, we shared findings with user interface designers and created a low-fidelity prototype...
June 19, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28637145/amount-of-balance-necessary-for-the-independence-of-transfer-and-stair-climbing-in-stroke-inpatients
#7
Takaaki Fujita, Atsushi Sato, Yuji Ohashi, Kazutaka Nishiyama, Takuro Ohashi, Kazuhiro Yamane, Yuichi Yamamoto, Kenji Tsuchiya, Koji Otsuki, Fusae Tozato
PURPOSE: The purpose of this study was to clarify the amount of balance necessary for the independence of transfer and stair-climbing in stroke patients. METHOD: This study included 111 stroke inpatients. Simple and multiple regression analyses were conducted to establish the association between the FIM(®) instrument scores for transfer or stair-climbing and Berg Balance Scale. Furthermore, receiver operating characteristic curves were used to elucidate the amount of balance necessary for the independence of transfer and stair-climbing...
February 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28637022/cdkn2a-methylation-in-esophageal-cancer-a-meta-analysis
#8
Chongchang Zhou, Jinyun Li, Qun Li
CDKN2A is a tumor suppressor gene and is frequently inactivated in human cancers by hypermethylation of its promoter. However, the role and diagnostic value of CDKN2A methylation in esophageal cancer (EC) remains controversial. Therefore, we performed a meta-analysis, including data from 42 articles (2656 ECs, 612 precancerous lesions, and 2367 controls). A significant increase in the frequency of CDKN2A methylation was identified during EC carcinogenesis: cancer vs. controls, odds ratio (OR) = 12.60 (95 % CI, 8...
June 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636922/an-experimental-framework-for-quantifying-bacterial-tolerance
#9
Asher Brauner, Noam Shoresh, Ofer Fridman, Nathalie Q Balaban
Antibiotic tolerance and persistence are often associated with treatment failure and relapse, yet are poorly characterized. In distinction from resistance, which is measured using the minimum inhibitory concentration metric, tolerance and persistence values are not currently evaluated in the clinical setting, and so are overlooked when a course of treatment is prescribed. In this article, we introduce a metric and an automated experimental framework for measuring tolerance and persistence. The tolerance metric is the minimum duration for killing 99% of the population, MDK99, which can be evaluated by a statistical analysis of measurements performed manually or using a robotic system...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28636890/memory-t-cells-a-helpful-guard-for-allogeneic-hematopoietic-stem-cell-transplantation-without-causing-graft-versus-host-disease
#10
REVIEW
Wei Huang, Nelson J Chao
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (AHSCT) and the major cause of nonrelapse morbidity and mortality of AHSCT. In AHSCT, donor T cells facilitate hematopoietic stem cell (HSC) engraftment, contribute to anti-infection immunity, and mediate graft-versus-leukemia (GVL) responses. However, activated alloreactive T cells also attack recipient cells in vital organs, leading to GVHD. Different T-cell subsets, including naïve T (TN) cells, memory T (TM) cells, and regulatory T (Treg) cells mediate different forms of GVHD and GVL; TN cells mediate severe GVHD, whereas TM cells do not cause GVHD, but preserve T-cell function including GVL...
June 13, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28636404/examining-the-association-between-health-literacy-and-medication-adherence-among-older-adults
#11
Tilicia L Mayo-Gamble, Charles Mouton
Health literacy plays a vital role in patients' understanding of their prescribed medication instructions. To inform strategies to assist providers in communicating in a manner that is easily understood by patients, it would be beneficial to determine the relationship between health literacy and the day-to-day aspects of medication adherence. This study identified: 1) differences of health literacy levels in medication adherence; 2) the association between health literacy and medication adherence; and 3) and factors associated with medication adherence score...
June 21, 2017: Health Communication
https://www.readbyqxmd.com/read/28636208/a-phase-i-trial-of-prn1008-a-novel-reversible-covalent-inhibitor-of-bruton-s-tyrosine-kinase-in-healthy-volunteers
#12
Patrick F Smith, Janakan Krishnarajah, Philip A Nunn, Ron J Hill, Dane Karr, D Tam, Mohammad Masjedizadeh, Jens O Funk, Steve G Gourlay
AIM: To evaluate the safety, tolerability, and PK/PD of PRN1008, a novel BTK inhibitor, in healthy volunteers, and thus determine the dose range for future clinical studies. METHODS: This was a two-part randomized, placebo controlled study in healthy volunteers using a liquid formulation. Part I was a single ascending dose design with dose levels of 50 to 1200 mg (n=6 active, 2 placebo per cohort); Part II was a multiple ascending dose design, with dose regimens ranging from 300 mg to 900 mg daily, either qd or bd for 10 days...
June 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28636192/intestinal-barrier-integrity-and-inflammatory-bowel-disease-stem-cell-based-approaches-to-regenerate-the-barrier
#13
REVIEW
Fredrik E O Holmberg, Jannie Pedersen, Peter Jørgensen, Christoffer Soendergaard, Kim B Jensen, Ole H Nielsen
Disruption of normal barrier function is a fundamental factor in the pathogenesis of inflammatory bowel disease, which includes increased epithelial cell death, modified mucus configuration, altered expression and distribution of tight junction-proteins, along with a decreased expression of antimicrobial peptides. Inflammatory bowel disease is associated with life-long morbidity for affected patients, and both the incidence and prevalence is increasing globally, resulting in substantial economic strain for society...
June 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28636116/curriculum-content-and-assessment-of-pre-clinical-dental-skills-a-survey-of-undergraduate-dental-education-in-europe
#14
J Field, S Stone, C Orsini, A Hussain, S Vital, A Crothers, D Walmsley
INTRODUCTION: Since 1981, the qualifications for various healthcare professionals across the European Union have enjoyed mutual recognition in accordance with the EU Directive 81/1057/EEC. Whilst the directive includes dental practitioners, it is recognised that significant variation exists in curriculum structure, content and scope of practice across institutions. This article aimed to explore pan-European practice in relation to curriculum content, teaching and learning strategies and assessment of pre-clinical dental skills...
June 21, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28636054/guidelines-for-surgical-approaches-for-minimally-invasive-plate-osteosynthesis-in-cats
#15
Philipp A Schmierer, Antonio Pozzi
OBJECTIVES: Minimally invasive plate osteosynthesis (MIPO) is one of the most recent fixation techniques that embody the concept of biological osteosynthesis. Several studies evaluating MIPO in dogs have been published in the recent years. However, there are few clinical reports of MIPO in cats and no description of the surgical approaches. The purpose of our study was to describe the safe corridors for plate insertion in cats using the MIPO technique. METHODS: The surgical approaches for the humerus, radius-ulna, femur and tibia were developed after reviewing the described techniques and surgical approaches for MIPO in dogs, while considering any relevant anatomical difference between dogs and cats...
June 21, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28635984/anxiety-and-depression-associated-with-burden-in-caregivers-of-patients-with-brain-metastases
#16
Marlon G Saria, Natasia S Courchesne, Lorraine Evangelista, Joshua L Carter, Daniel A MacManus, Mary Kay Gorman, Adeline M Nyamathi, Linda R Phillips, David E Piccioni, Santosh Kesari, Sally L Maliski
PURPOSE/OBJECTIVES: To describe and examine the relationship between caregiver burden and the affective disorders anxiety and depression in caregivers of patients with brain metastases.
. DESIGN: Cross-sectional, descriptive, correlational.
. SETTING: Moores Cancer Center at the University of California, San Diego. 
. SAMPLE: 56 family caregivers of patients with brain metastases from solid tumors at other primary sites...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28635471/off-camera
#17
Ed Freshwater
Wearing body cameras at work is a terrible idea, especially in settings where establishing a trusting therapeutic relationship is vital (readers' panel, 14 June).
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635447/-your-core-nursing-skills-are-vital
#18
(no author information available yet)
After taking up a nursing career in his thirties, Major Rob Instrell qualified in Southampton in 2002. He worked mainly in emergency care, and is now lead practitioner in critical care outreach at Blackpool Teaching Hospitals NHS Foundation Trust. In his military career, he has served as a troop commander and as the unit adjutant for 335 Medical Evacuation, and has been the regiment's clinical lead for the past four years.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28635289/exploring-the-drug-resistance-of-hcv-protease
#19
Garima Jindal, Dibyendu Mondal, Arieh Warshel
Hepatitis C virus (HCV) currently affects several million people across the globe. One of the major classes of drugs inhibits the NS3/4A protease of the polyprotein chain. Efficacy of these drugs is severely limited due to the high mutation rate that results in several genetically related quasispecies. The molecular mechanism of drug resistance is generally based on structural studies and binding free energies. However, prediction of new mutations requires a quantity that can define both binding free energy of the drug as well as the parameters (kcat and KM) for the natural substrate...
June 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28635088/arts-and-cultural-activity-a-vital-part-of-the-health-and-care-system
#20
Paul L Cann
This article discusses how the arts and cultural activities are a vital part of a health and care system and have potential to fulfil the theme of active ageing. The changing nature of care provision in response to demographic change, fiscal pressure and increasingly consumerist attitudes on the part of care users, is considered. Selected examples of how participation in arts and cultural activities increases not only well-being but also health outcomes are then outlined. The article highlights the potential of 'cultural commissioning' and within that 'arts on prescription' - public funding of arts-related activities for people with care needs - and advocates investment in arts and cultural activities to better meet the demands of health, social care and aged care...
June 2017: Australasian Journal on Ageing
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