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https://www.readbyqxmd.com/read/28728029/peroxidase-mimetic-activity-of-fe3o4-nanoparticle-prepared-based-on-magnetic-hydrogels-for-hydrogen-peroxide-and-glucose-detection
#1
Shasha Song, Yang Liu, Aixin Song, Zengdian Zhao, Hongsheng Lu, Jingcheng Hao
Stimuli-response magnetic hydrogels were prepared in the mixtures of magnetic surfactants, (CnTAFB(C), n=12, 14, 16), and chiral amphiphiles, sodium cholate (SC). The gelation behavior of CnTAFB(C)/SC were studied in detail. The results proved that the hydrophobicity of surfactants and the hydration radius (Rh) of anions played a vital role in the gelation process. The microstructure of the hydrogels were determined to be three-dimensional network of fibrous aggregates. The formation of the hydrogel fibrils was considered to be mainly driven by a delicate balance of multiple non-covalent interactions including hydrophobic interaction, electrostatic interaction, hydrogen bonding, van der Waals force, and the steric effect of SC molecule...
July 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28728020/neuroscience-inspired-artificial-intelligence
#2
REVIEW
Demis Hassabis, Dharshan Kumaran, Christopher Summerfield, Matthew Botvinick
The fields of neuroscience and artificial intelligence (AI) have a long and intertwined history. In more recent times, however, communication and collaboration between the two fields has become less commonplace. In this article, we argue that better understanding biological brains could play a vital role in building intelligent machines. We survey historical interactions between the AI and neuroscience fields and emphasize current advances in AI that have been inspired by the study of neural computation in humans and other animals...
July 19, 2017: Neuron
https://www.readbyqxmd.com/read/28727686/fbxw7-regulates-disc1-stability-via-the-ubiquitin-proteosome-system
#3
K Yalla, C Elliott, J P Day, J Findlay, S Barratt, Z A Hughes, L Wilson, E Whiteley, M Popiolek, Y Li, J Dunlop, R Killick, D R Adams, N J Brandon, M D Houslay, B Hao, G S Baillie
Disrupted in schizophrenia 1 (DISC1) is a multi-functional scaffolding protein that has been associated with neuropsychiatric disease. The role of DISC1 is to assemble protein complexes that promote neural development and signaling, hence tight control of the concentration of cellular DISC1 in neurons is vital to brain function. Using structural and biochemical techniques, we show for we believe the first time that not only is DISC1 turnover elicited by the ubiquitin proteasome system (UPS) but that it is orchestrated by the F-Box protein, FBXW7...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28727486/association-of-physician-orders-for-life-sustaining-treatment-form-use-with-end-of-life-care-quality-metrics-in-patients-with-cancer
#4
Sandra L Pedraza, Stacey Culp, Mark Knestrick, Evan Falkenstine, Alvin H Moss
PURPOSE: Many patients with advanced cancer receive aggressive treatment near the end of life. The Physician Orders for Life-Sustaining Treatment (POLST) form is an innovation that converts patient preferences into medical orders. We compared the end-of-life care of patients with advanced cancer who had completed POLST forms with that of patients who had advance directives (ADs). METHODS: We studied 2,159 West Virginians with ADs and/or POLST forms in the West Virginia e-Directive Registry who died as a result of cancer between January 2011 and February 2016...
July 20, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28727215/neutrophil-extracellular-traps-coincide-with-a-pro-coagulant-status-of-microcirculatory-endothelium-in-burn-wounds
#5
H Ibrahim Korkmaz, Magda M W Ulrich, Sanne Vogels, Tim de Wit, Paul P M van Zuijlen, Paul A J Krijnen, Hans W M Niessen
Burn-induced tissue loss is partly related to secondary expansion of necrosis into vital dermis neighbouring the initial burn injury. An important factor herein is the severe loss of perfusion of the burn wound, probably caused by microvascular damage induced by the intense local inflammatory responses as well as burn-induced hypercoagulation. We hypothesize that the formation of Neutrophilic Extracellular Traps (NETs) play an important role in this. The purpose of this study was to investigate post-burn intravascular thrombosis, NETs formation and the coagulant state in the microvasculature of burns in both animal models and patients...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28727164/the-innate-host-response-in-caries-and-periodontitis
#6
Joerg Meyle, Henrik Dommisch, Sabine Groeger, Rodrigo A Giacaman, Massimo Costalonga, Mark Herzberg
Innate immunity rapidly defends the host against infectious insults. These reactions are of limited specificity and exhaust without providing long-term protection. Functional fluids and effector molecules contribute to the defence against infectious agents, drive the immune response, and direct the cellular players. AIM: To review the literature and present a summary of current knowledge about the function of tissues, cellular players and soluble mediators of innate immunity relevant to caries and periodontitis...
July 20, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28727118/technical-note-assessment-of-an-alternative-technique-for-measuring-body-temperature-in-pigs
#7
A Petry, W McGilvray, A R Rakhshandeh, A Rakhshandeh
Core body temperature (CBT) is one of the main vital signs that is used to evaluate the health status of pigs. The most common and feasible method for assessing CBT in pigs is rectal temperature (RT). Obtaining RT is stressful for animals, may generate inaccurate results, and has the risk of spreading disease. Infrared imaging (IR) thermography of the body of pigs may be a safer and less stressful alternative to RT. The objective of the current study was to evaluate the efficacy of using IR as an alternative for monitoring CBT in pigs...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727117/relationship-between-ovulation-rate-and-embryonic-characteristics-in-gilts-at-35-d-of-pregnancy
#8
C L A Da Silva, M L W J Broekhuijse, B F A Laurenssen, H A Mulder, E F Knol, B Kemp, N M Soede
This study investigated the relationship between ovulation rate (OR) and embryonic characteristics in gilts. Landrace ( = 86) and Yorkshire x Landrace ( = 212) gilts were inseminated with semen stored for 3 to 5 d (SS1, = 59), 6 to7 d (SS2, = 133), or 8 to 10 d (SS3, = 106), and slaughtered at 35 d of pregnancy. Ovulation rate was assessed by dissection of the corpora lutea on both ovaries. Embryos were classified as vital (VE) by visual appearance and individually weighed (VEg) and the SD of the weight calculated (SDVEg)...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727115/the-microbiota-gut-brain-axis-as-a-key-regulator-of-neural-function-and-the-stress-response-implications-for-human-and-animal-health
#9
N C Wiley, T G Dinan, R P Ross, C Stanton, G Clarke, J F Cryan
The brain-gut-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. Development of a diverse gut microbiota is vital for multiple features of behavior and physiology, as well as many fundamental aspects of brain structure and function. Appropriate early-life assembly of the gut microbiota is also believed to play a role in subsequent emotional and cognitive development. If the composition, diversity, or assembly of the gut microbiota is impaired, this impairment can have a negative impact on host health and lead to disorders such as obesity, diabetes, inflammatory diseases, and even potentially neuropsychiatric illnesses, including anxiety and depression...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727025/effect-of-handling-intensity-at-the-time-of-transport-for-slaughter-on-physiological-response-and-carcass-characteristics-in-beef-cattle-fed-ractopamine-hydrochloride
#10
J A Hagenmaier, C D Reinhardt, S J Bartle, J N Henningson, M J Ritter, M S Calvo-Lorenzo, G J Vogel, C A Guthrie, M G Siemens, D U Thomson
The effects of handling intensity on the physiological response and carcass characteristics of feedlot cattle fed ractopamine hydrochloride were evaluated at the time of transport to slaughter. Eighty steers (BW = 668 ± 36 kg) representing 10 lots of similar breed, frame size, and degree of finish were blocked by lot, stratified by weight, and randomly assigned to 1 of 2 handling intensities (HI) over a 1,600 m dirt alley course: 1) low-stress handling (LSH) or 2) high-stress handling (HSH). For the LSH treatment, 4 penmates were kept at a walk with the use of a lead rider...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28727010/effect-of-experimentally-increased-protein-supply-to-postpartum-dairy-cows-on-plasma-protein-synthesis-rumen-tissue-proliferation-and-immune-homeostasis
#11
M Larsen, C M Røntved, P K Theil, M Khatun, C Lauridsen, N B Kristensen
The effect of experimentally increasing the postpartum protein supply on plasma protein synthesis, rumen tissue proliferation, and immune homeostasis was studied using 8 periparturient Holstein cows in a complete randomized design. At calving, cows were assigned to abomasal infusion of water (CTRL) or casein (CAS) in addition to a lactation diet. Casein infusion was gradually decreased from 696 ± 1 g/d at +2 d relative to calving (DRTC) to 212 ± 10 g/d at +29 DRTC to avoid excessive supply. Synthesis rate of plasma proteins was measured at -14, +4, +15, and +29 DRTC by measuring [C]Phe isotopic enrichment in arterial plasma free Phe, total plasma proteins, and albumin after 3, 5, and 7 h of jugular ring[C]Phe infusion...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726492/does-cognition-specific-computer-training-have-better-clinical-outcomes-than-non-specific-computer-training-a-single-blind-randomized-controlled-trial
#12
Ji-Hyuk Park, Jin-Hyuck Park
OBJECTIVE: The purpose of this study was to investigate differences between non-specific computer training (NCT) and cognition-specific computer training (CCT). DESIGN: Randomized controlled experimental study. SETTING: Local community welfare center. SUBJECTS: A total of 78 subjects with mild cognitive impairment (MCI) were randomly assigned to the NCT ( n = 39) or CCT group ( n = 39). INTERVENTION: The NCT group underwent NCT using Nintendo Wii for improving functional performance, while the CCT group underwent CCT using CoTras for improving function of the cognitive domain specifically...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28726458/getting-started-reply-to-condon-et-al-2017-and-rossiter-2017
#13
Karen A Matthews, Nancy E Adler, Christopher B Forrest, William W Stead
Condon, Weston, and Hill (2017) and Rossiter (2017) expressed concerns about the recommended panel of psychosocial vital signs that should be included in electronic health records (EHRs). Condon et al. (2017) would prefer a broader array of measures and Rossiter (2017) a set of optimal measures based on consensus. Our task was to identify a core set of measures to be used now in all EHRs based on usefulness and low burden. We anticipate that with new evidence, changing needs, and greater input from stakeholders, the recommended measures will be elaborated or modified...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28726456/reconsidering-what-is-vital-about-vital-signs-in-electronic-health-records-comment-on-matthews-et-al-2016
#14
David M Condon, Sara J Weston, Patrick L Hill
The inclusion of psychosocial variables into electronic health records provides a unique opportunity for the translation of findings from social, psychological, and behavioral domains into patient care. This commentary is a response to the recommendations of a committee convened by the Institute of Medicine to address this opportunity (Matthews, Adler, Forrest, & Stead, 2016). We concur with the committee that the inclusion of psychosocial variables in electronic health records will broadly benefit researchers, practitioners, and patients and that there is clear need for a recommended panel of psychosocial measures that is ready for implementation in clinical settings...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28726371/multilayer-regulation-of-atomic-boron-nitride-films-to-improve-oxidation-and-corrosion-resistance-of-cu
#15
Siming Ren, Mingjun Cui, Jibin Pu, Qunji Xue, Liping Wang
Boron nitride (BN) monolayer (1L) with high impermeability and resistivity seems to hold promise as a long-term corrosion barrier for Cu at ambient condition, which is supported by recent researches. Here we perform a complete study of the alternating temperature tests (the sample is exposed in air for 30 days and subsequently heated at 200 ℃ for 2 h) and electrochemical measurements on 1L and multilayers BN coated Cu foils. Results imply that the BN coated Cu foils are less oxidized than uncoated Cu foil after alternating temperature tests, regardless of the layers of BN...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28726343/cultural-misconceptions-and-public-stigma-against-mental-illness-among-lebanese-university-students
#16
Ahmad Rayan, Mirna Fawaz
PURPOSE: The purpose of this study was to examine cultural misconceptions about mental illness and how they are associated with the public stigma against mental illness among Lebanese university students. METHODS: A sample of 203 participants completed the study. Data about cultural misconceptions, attitudes about mental illness, and public stigma of mental illness were obtained. The researchers examined the mean difference in public stigma according to cultural beliefs about mental illness...
July 20, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28726098/magnetic-dependent-atp-pool-in-escherichia-coli
#17
U G Letuta, E I Avdeeva
The ATP pool in Escherichia coli is a magnetic-dependent characteristic of microorganism vital activity. It depends on the values of the external static magnetic field and the existence of magnetic moment of magnesium isotopes nuclei added to the growth nutrient medium. The combined effects of the magnetic field 70-95 mT and magnesium magnetic isotope (25)Mg on E. coli bacteria leads to increase intracellular concentration of ATP. Magnetic-field effects in the range of 0.8-16 mT, registered for all bacteria regardless of the magnesium-isotopic enrichment of nutrient medium, evidence about the sensitivity of intracellular processes to weak magnetic fields...
May 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28726079/bilirubin-enzyme-biosensor-potentiality-and-recent-advances-towards-clinical-bioanalysis
#18
REVIEW
Vinita Hooda, Anjum Gahlaut, Ashish Gothwal, Vikas Hooda
Bilirubin detection plays a major role in healthcare. Its high concentration in human serum is lethal and must be determined accurately. Clinically, it is vital for assessing patients with deleterious health conditions such as jaundice or icterus, hepatitis, mental disorders, cerebral palsy and brain damage especially in the case of neonates. In evaluating the drawbacks regarding the conventional methodology of bilirubin detection, there is need for a superior analytical tool. Bilirubin oxidase (BOx)-based sensors have been designed for the ultrasensitive analysis of bilirubin and quality deliverance of treatment and this review highlights the different mechanisms of bilirubin detection using different modified electrodes...
July 19, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28725865/the-science-of-empathy
#19
Helen Riess
Empathy plays a critical interpersonal and societal role, enabling sharing of experiences, needs, and desires between individuals and providing an emotional bridge that promotes pro-social behavior. This capacity requires an exquisite interplay of neural networks and enables us to perceive the emotions of others, resonate with them emotionally and cognitively, to take in the perspective of others, and to distinguish between our own and others' emotions. Studies show empathy declines during medical training...
June 2017: Journal of patient experience
https://www.readbyqxmd.com/read/28725636/epithelial-to-mesenchymal-transition-in-the-female-reproductive-tract-from-normal-functioning-to-disease-pathology
#20
REVIEW
Olena Bilyk, Mackenzie Coatham, Michael Jewer, Lynne-Marie Postovit
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis...
2017: Frontiers in Oncology
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