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https://www.readbyqxmd.com/read/28231660/-effect-of-telbivudine-on-infants-born-to-hbsag-positive-mothers-with-non-hypo-response-to-hepatitis-b-vaccine-during-their-second-and-third-trimesters-of-pregnancy
#1
X X Xu, B Wang, X F Wang, H X Wen, F Zhang, Z Q Yang, H Y Hao, T Wang, X H Shi, Z D Fu, B Wang, S P Wang
Objective: To explore the effect of telbivudine treatment in a prevention program on infants born to HBsAg-positive mothers with non-/hypo-responsiveness to hepatitis B vaccine. Methods: A retrospective cohort study with a total of 321 HBsAg-positive pregnant women and their infants enrolled, was conducted. The mothers were recruited from the Third People' s Hospital of Taiyuan, from July 2011 to January 2013. According to the situation of telbivudine intake in second and third trimesters of pregnancy, the participants were divided into two groups: with telbivudine-treated or as control...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231656/-acute-effect-of-ambient-air-pollution-on-small-airway-lung-functions-among-school-children-in-shanghai
#2
L J Zhang, C Y Guo, H H Xu, D Xu, X B Shen, X Y Du, M H Zhang, J G Tan, J H Zhang, C Y Dong, H L Qian, Y W Shi, M Z Pan, X D Zhou
Objective: To study the acute effects of compound ambient air pollution on small airway lung functions among school children in Shanghai. Method: A longitudinal survey on lung functions was conducted among 233 school-children from three schools (A, B and C, located in innerring, mid-ring and outer-ring areas). Lung function test was performed once a week for 3 times respectively, among children in school A and B in Dec. 2013 and in school C in Dec. 2014. The fourth lung function test was tested in Jun. 2014 and May 2015 in the respective schools...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231490/lipid-droplet-growth-regulation-of-a-dynamic-organelle
#3
REVIEW
David Barneda, Mark Christian
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic cells, it is adipocytes that present the widest range of sizes up to the massive unilocular droplet of a white adipocyte. Our knowledge of the proteins and associated processes that control LD dynamics is improving...
February 20, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28231060/improving-quality-in-the-preanalytical-phase-through-innovation-on-behalf-of-the-european-federation-for-clinical-chemistry-and-laboratory-medicine-eflm-working-group-for-preanalytical-phase-wg-pre
#4
Giuseppe Lippi, Geoffrey S Baird, Giuseppe Banfi, Karin Bölenius, Janne Cadamuro, Stephen Church, Michael P Cornes, Anna Dacey, Antoine Guillon, Georg Hoffmann, Mads Nybo, Lakdasa Devananda Premawardhana, María Salinas, Sverre Sandberg, Robbert Slingerland, Ana Stankovic, Sylte Marit Sverresdotter, Pieter Vermeersch, Ana-Maria Simundic
It is now undeniable that laboratory testing is vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite the many advances made for achieving a high degree of quality and safety in the analytical part of diagnostic testing, many hurdles in the total testing process remain, especially in the preanalytical phase ranging from test ordering to obtaining and managing the biological specimens. The Working Group for the Preanalytical Phase (WG-PRE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has planned many activities aimed at mitigating the vulnerability of the preanalytical phase, including the organization of three European meetings in the past 7 years...
February 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28231032/effects-of-live-trapping-and-isoflurane-anesthesia-on-free-ranging-american-martens-martes-americana
#5
Maria C Spriggs, Lisa I Muller, Paul Keenlance, Robert L Sanders, Jill C Witt, Debra L Miller
Seventy-two free-ranging American martens ( Martes americana ) in Michigan were immobilized using isoflurane from 2011 to 2015. In total, 129 anesthetic procedures were performed with no mortalities. Hypothermia and hyperthermia were the most common anesthetic complications, and the mean rectal temperatures were significantly higher during summer than in winter. Dental abnormalities were common; the majority of abnormal findings were broken or discolored teeth attributed to previous dental trauma and were not trap-induced...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28230921/prevalence-of-promoter-mutations-in-the-tert-gene-in-oral-cavity-squamous-cell-carcinoma
#6
Kai-Ping Chang, Chun-I Wang, Curtis R Pickering, Yenlin Huang, Chi-Neu Tsai, Ngan-Ming Tsang, Huang-Kai Kao, Ming-Huei Cheng, Jeffrey N Myers
BACKGROUND: Mutations in the human telomerase reverse transcriptase (TERT) promoter contribute to increased TERT activity. The purpose of the present study was to assess the prevalence of TERT promoter mutations in oral cavity squamous cell carcinoma (SCC). METHODS: Total DNA was extracted from 201 oral cavity SCC tumors and adjacent normal tissues. Primers were used to amplify the sequence region containing 2 TERT promoter mutations (C228T and C250T) that were then sequenced using the Sanger method...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28230831/incidence-of-multiple-myeloma-among-cleanup-workers-of-the-chornobyl-accident-and-their-survival
#7
D Bazyka, N Gudzenko, I Dyagil, N Trotsiuk, E Gorokh, Z Fedorenko, V Chumak, E Bakhanova, I Ilienko, A Romanenko
: The study presents the updated data on the multiple myeloma (MM) incidence in Ukrainian cleanup workers after the Chornobyl accident and their survival. The epidemiological analysis is based on the extended follow-up period to identify new MM cases for higher statistical power and to collect additional data on the disease course and outcome for the survival analysis. The objective of the study was to analyze the MM incidence and survival in Chornobyl cleanup workers in 1996-2013 in comparison with the national MM statistical data...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230588/how-to-expose-the-entire-sella-floor-with-minimal-manipulation-during-an-endoscopic-endonasal-transsphenoidal-approach
#8
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Yong Jin Park, Soo Whan Kim, Jin Hee Cho, Boo-Young Kim, Sung Won Kim
OBJECTIVE: A method of opening the posterior ethmoid air cells with minimal manipulation is important for adequate exposure of the sella floor and minimal nasal morbidity. METHODS: Between February 2009 and August 2016, 373 patients with skull-base tumors underwent surgery via endoscopic endonasal transsphenoidal approach with the 2-nostrils/4-hands technique using this technique. RESULTS: A linear incision was made laterally toward one-third of the superior turbinate along the superior border of the sphenoid sinus ostium...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230406/test-retest-reliability-of-the-facial-expression-labeling-task
#9
Jennifer L Cecilione, Lance M Rappaport, Brad Verhulst, Dever M Carney, R J R Blair, Melissa A Brotman, Ellen Leibenluft, Daniel S Pine, Roxann Roberson-Nay, John M Hettema
Recognizing others' emotional expressions is vital for socioemotional development; impairments in this ability occur in several psychiatric disorders. Further study is needed to map the development of this ability and to evaluate its components as potential transdiagnostic endophenotypes. Before doing so, however, research is required to substantiate the test-retest reliability of scores of the face emotion identification tasks linked to developmental psychopathology. The current study estimated test-retest reliability of scores of one such task, the facial expression labeling task (FELT) among a sample of twin children (N = 157; ages 9-14)...
February 23, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28230247/digest-less-than-the-sum-of-its-parts-negative-epistasis-in-bacterial-swarming
#10
Sonia Singhal, Katrina van Raay
Understanding how mutations change phenotypes is vital to evolutionary biology. However, predicting evolutionary outcomes is complicated by the fact that a mutation's effect may depend on the individual's genetic background. Epistasis occurs when interactions among different genes or mutations result in phenotypes that differ from the sum of their parts. Uncovering epistasis usually involves genetic engineering of point mutations and then comparing the phenotypic effect of each mutation individually against its effect in combination with others (e...
February 23, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28230178/large-area-growth-of-multi-layer-hexagonal-boron-nitride-on-polished-cobalt-foils-by-plasma-assisted-molecular-beam-epitaxy
#11
Zhongguang Xu, Hao Tian, Alireza Khanaki, Renjing Zheng, Mohammad Suja, Jianlin Liu
Two-dimensional (2D) hexagonal boron nitride (h-BN), which has a similar honeycomb lattice structure to graphene, is promising as a dielectric material for a wide variety of potential applications based on 2D materials. Synthesis of high-quality, large-size and single-crystalline h-BN domains is of vital importance for fundamental research as well as practical applications. In this work, we report the growth of h-BN films on mechanically polished cobalt (Co) foils using plasma-assisted molecular beam epitaxy...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230034/effect-of-dezocine-combined-with-propofol-on-painless-gastroscopy-in-patients-with-suspect-gastric-carcinoma
#12
Ji Ma, Peng Zhang, Yixuan Zhang, Zong Chen, Wenqi Xin, Donghang Zhang, Chuangeng Ma
OBJECTIVE: To evaluate the effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma. METHODS: Forty-three patients with gastric carcinoma who have underwent painless gastroscopy were retrospectively analyzed. For the 43 patients, 21 patients received propofol 1 mg/kg for painless gastroscopy (control group) and other 22 cases received dezocine 20 µg/kg plus propofol 1 mg/kg for painless gastroscopy (experiment group)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229942/dissecting-the-role-of-the-elongation-factor-1a-isoforms-in-hepatocellular-carcinoma-cells-by-liposome-mediated-delivery-of-sirnas
#13
Rossella Farra, Bruna Scaggiante, Chiara Guerra, Gabriele Pozzato, Mario Grassi, Fabrizio Zanconati, Francesca Perrone, Cinzia Ferrari, Francesco Trotta, Gabriele Grassi, Barbara Dapas
Eukaryotic elongation factor 1A (eEF1A), a protein involved in protein synthesis, has two major isoforms, eEF1A1 and eEF1A2. Despite the evidences of their involvement in hepatocellular carcinoma (HCC), the quantitative contribution of each of the two isoforms to the disease is unknown. We depleted the two isoforms by means of siRNAs and studied the effects in three different HCC cell lines. Particular care was dedicated to select siRNAs able to target each of the two isoform without affecting the other one...
February 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28229841/-neuroimaging-and-blood-biomarkers-in-functional-prognosis-after-stroke
#14
REVIEW
João Paulo Branco, Joana Santos Costa, João Sargento-Freitas, Sandra Oliveira, Bruno Mendes, Jorge Laíns, João Pinheiro
INTRODUCTION: Stroke remains one of the leading causes of morbidity and mortality around the world and it is associated with an important long-term functional disability. Some neuroimaging resources and certain peripheral blood or cerebrospinal fluid proteins can give important information about etiology, therapeutic approach, follow-up and functional prognosis in acute ischemic stroke patients. However, among the scientific community, there is currently more interest in the stroke vital prognosis over the functional prognosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229491/osnla1-a-ring-type-ubiquitin-ligase-maintains-phosphate-homeostasis-in-oryza-sativa-via-degradation-of-phosphate-transporters
#15
Wenhao Yue, Yinghui Ying, Chuang Wang, Yang Zhao, Changhe Dong, James Whelan, Huixia Shou
Inorganic phosphate (Pi) transporters (PTs) play vital roles in Pi uptake and translocation in plants. Under Pi sufficient conditions, PTs are degraded to prevent excess Pi accumulation. The mechanisms targeting PTs for degradation are not fully elucidated. In this study, we found that the Oryza sativa (rice) ortholog of Arabidopsis thaliana Nitrogen Limitation Adaptation (NLA), OsNLA1 protein, a RING-type E3 ubiquitin-ligase, was predominantly localized in the plasma membrane, and could interact with rice phosphate transporters OsPT2 and OsPT8...
February 23, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28229476/initial-medication-non-adherence-prevalence-and-predictive-factors-in-a-cohort-of-1-6-million-primary-care-patients
#16
I Aznar-Lou, A Fernández, M Gil-Girbau, M Fajó-Pascual, P Moreno-Peral, M T Peñarrubia-Maria, A Serrano-Blanco, A Sánchez-Niubó, M March-Pujol, A M Jové, M Rubio-Valera
INTRODUCTION: Adherence to medicines is vital in treating diseases. Initial medication non-adherence (IMNA) - defined as not obtaining a medication the first time it is prescribed - has been poorly explored. Previous studies show IMNA rates between 6 and 28% in Primary Care (PC). The aims of this study were to determine prevalence and predictive factors of IMNA in the most prescribed and expensive pharmacotherapeutic groups in the Catalan health system. METHODS: Retrospective, register-based cohort study which linked Catalan PC System (Spain) prescription and invoicing databases...
February 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28229412/isolation-characterization-and-expansion-of-cancer-stem-cells
#17
Luke A Torre-Healy, Artem Berezovsky, Justin D Lathia
The ability to isolate, characterize, and expand distinct tumor cell populations from primary tissue or xenografts is vital to identifying molecular mechanisms specific to cancer stem cells. Once cells have been extracted from tissue, there are multiple methods by which they can be sorted and cultured. We will describe the approaches that can be taken from cancer stem cell isolation through expansion, including Magnetic-activated Cell Sorting (MACS), Fluorescence-activated Cell Sorting (FACS), the use of reporter systems, and various cell culture methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229383/mirna-based-heavy-metal-homeostasis-and-plant-growth
#18
Ali Noman, Muhammad Aqeel
Plants have been naturally gifted with mechanisms to adjust under very high or low nutrient concentrations. Heavy metal toxicity is considered as a major growth and yield-limiting factor for plants. This stress includes essential as well as non-essential metals. MicroRNAs (miRNAs) are known for mediating post-transcriptional regulation by cleaving transcripts or translational inhibition. It is commonly agreed that an extensive understanding of plant miRNAs will significantly help in the induction of tolerance against environmental stresses...
February 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28229353/cardiorespiratory-instability-in-monitored-step-down-unit-patients-using-cluster-analysis-to-identify-patterns-of-change
#19
Eliezer L Bose, Gilles Clermont, Lujie Chen, Artur W Dubrawski, Dianxu Ren, Leslie A Hoffman, Michael R Pinsky, Marilyn Hravnak
Cardiorespiratory instability (CRI) in monitored step-down unit (SDU) patients has a variety of etiologies, and likely manifests in patterns of vital signs (VS) changes. We explored use of clustering techniques to identify patterns in the initial CRI epoch (CRI1; first exceedances of VS beyond stability thresholds after SDU admission) of unstable patients, and inter-cluster differences in admission characteristics and outcomes. Continuous noninvasive monitoring of heart rate (HR), respiratory rate (RR), and pulse oximetry (SpO2) were sampled at 1/20 Hz...
February 22, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28229352/linshom-thermodynamic-sensor-is-a-reliable-alternative-to-capnography-for-monitoring-respiratory-rate
#20
David Preiss, Benjamin A Drew, James Gosnell, Bhavani S Kodali, James H Philip, Richard D Urman
Monitoring ventilation accurately is a technically challenging, yet indispensable aspect of patient care in the intra- and post-procedural settings. A new prototypical device known as the Linshom Respiratory Monitoring Device (LRMD) has been recently designed to non-invasively, inexpensively, and portably measure respiratory rate. The purpose of this study was to measure the accuracy and variability of LRMD measurements of respiratory rate relative to the measurement of capnography. In this prospective study, participants were enrolled and individually fitted with a face mask monitored by the LRMD and capnography...
February 22, 2017: Journal of Clinical Monitoring and Computing
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