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Cardiac radiation

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https://www.readbyqxmd.com/read/28334658/extraction-of-the-3d-local-orientation-of-myocytes-in-human-cardiac-tissue-using-x-ray-phase-contrast-micro-tomography-and-multi-scale-analysis
#1
François Varray, Iulia Mirea, Max Langer, Françoise Peyrin, Laurent Fanton, Isabelle E Magnin
This paper presents a methodology to access the 3D local myocyte arrangements in fresh human post-mortem heart samples. We investigated the cardiac micro-structure at a high and isotropic resolution of 3.5 µm in three dimensions using X-ray phase micro-tomography at the European Synchrotron Radiation Facility. We then processed the reconstructed volumes to extract the 3D local orientation of the myocytes using a multi-scale approach with no segmentation. We created a simplified 3D model of tissue sample made of simulated myocytes with known size and orientations, to evaluate our orientation extraction method...
February 20, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28333397/cardiac-device-implantations-in-obese-patients-success-rates-and-complications
#2
Philipp Attanasio, Philipp Lacour, Andrea Ernert, Burkert Pieske, Wilhelm Haverkamp, Florian Blaschke, Francesco Dalle Vedove, Martin Huemer
BACKGROUND: Obesity is associated with increased complications and potentially worse outcomes for various cardiac interventions. This study analyzed the success rate and complication rates associated with implantation of cardiac implantable electronic devices (CIEDs) in obese patients. HYPOTHESIS: Success rates are lower and complication rates higher in obese patients. METHODS: Consecutive patients undergoing CIED implantation between 2011 and 2015 in our hospital were included...
March 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28333021/a-phase-1-2-trial-of-a-combination-of-paclitaxel-and-trastuzumab-with-daily-irradiation-or-paclitaxel-alone-with-daily-irradiation-after-transurethral-surgery-for-noncystectomy-candidates-with-muscle-invasive-bladder-cancer-trial-nrg-oncology-rtog-0524
#3
M Dror Michaelson, Chen Hu, Huong T Pham, Douglas M Dahl, Chin Lee-Wu, Gregory P Swanson, Jacqueline Vuky, R Jeffrey Lee, Luis Souhami, Brian Chang, Asha George, Howard Sandler, William Shipley
PURPOSE: Bladder preservation therapy is an effective treatment for muscle-invasive urothelial carcinoma (UC). In this study we treated noncystectomy candidates with daily radiation and weekly paclitaxel for 7 weeks. Patients whose tumors showed her2/neu overexpression were additionally treated with weekly trastuzumab. METHODS AND MATERIALS: Sixty-eight evaluable patients were treated with radiation therapy and either paclitaxel + trastuzumab (group 1) or paclitaxel alone (group 2)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28333011/utility-of-deep-inspiration-breath-hold-for-left-sided-breast-radiation-therapy-in-preventing-early-cardiac-perfusion-defects-a-prospective-study
#4
Timothy M Zagar, Orit Kaidar-Person, Xiaoli Tang, Ellen E Jones, Jason Matney, Shiva K Das, Rebecca L Green, Arif Sheikh, Amir H Khandani, William H McCartney, Jorge Daniel Oldan, Terence Z Wong, Lawrence B Marks
PURPOSE: To evaluate early cardiac single photon computed tomography (SPECT) findings after left breast/chest wall postoperative radiation therapy (RT) in the setting of deep inspiration breath hold (DIBH). METHODS AND MATERIALS: We performed a prospective single-institution single-arm study of patients who were planned for tangential RT with DIBH to the left breast/chest wall (± internal mammary nodes). The DIBH was done by use of a controlled surface monitoring technique (AlignRT, Vision RT Ltd, London, UK)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332991/accelerated-total-lymphoid-irradiation-containing-salvage-regimen-for-patients-with-refractory-and-relapsed-hodgkin-lymphoma-20%C3%A2-years-of-experience
#5
Andreas Rimner, Shona Lovie, Meier Hsu, Monica Chelius, Zhigang Zhang, Karen Chau, Alison J Moskowitz, Matthew Matasar, Craig H Moskowitz, Joachim Yahalom
PURPOSE: We report the long-term results of integrated accelerated involved field radiation therapy (IFRT) followed by total lymphoid irradiation (TLI) as part of the high-dose salvage regimen followed by autologous bone marrow transplantation or autologous stem cell transplantation in patients with relapsed or refractory Hodgkin lymphoma (HL). METHODS AND MATERIALS: From November 1985 to July 2008, 186 previously unirradiated patients with relapsed or refractory HL underwent salvage therapy on 4 consecutive institutional review board-approved protocols...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28329054/whole-heart-detailed-and-quantitative-anatomy-myofibre-structure-and-vasculature-from-x-ray-phase-contrast-synchrotron-radiation-based-micro-computed-tomography
#6
Anna Gonzalez-Tendero, Chong Zhang, Vedrana Balicevic, Rubén Cárdenes, Sven Loncaric, Constantine Butakoff, Bruno Paun, Anne Bonnin, Patricia Garcia-Cañadilla, Emma Muñoz-Moreno, Eduard Gratacós, Fatima Crispi, Bart Bijnens
Background: While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels...
March 15, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28319436/estimating-the-risks-of-breast-cancer-radiotherapy-evidence-from-modern-radiation-doses-to-the-lungs-and-heart-and-from-previous-randomized-trials
#7
Carolyn Taylor, Candace Correa, Frances K Duane, Marianne C Aznar, Stewart J Anderson, Jonas Bergh, David Dodwell, Marianne Ewertz, Richard Gray, Reshma Jagsi, Lori Pierce, Kathleen I Pritchard, Sandra Swain, Zhe Wang, Yaochen Wang, Tim Whelan, Richard Peto, Paul McGale
Purpose Radiotherapy reduces the absolute risk of breast cancer mortality by a few percentage points in suitable women but can cause a second cancer or heart disease decades later. We estimated the absolute long-term risks of modern breast cancer radiotherapy. Methods First, a systematic literature review was performed of lung and heart doses in breast cancer regimens published during 2010 to 2015. Second, individual patient data meta-analyses of 40,781 women randomly assigned to breast cancer radiotherapy versus no radiotherapy in 75 trials yielded rate ratios (RRs) for second primary cancers and cause-specific mortality and excess RRs (ERRs) per Gy for incident lung cancer and cardiac mortality...
March 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28318657/radiation-dose-among-different-cardiac-and-vascular-invasive-procedures-the-rodeo-study
#8
Alessandro Sciahbasi, Giuseppe Ferrante, Dionigi Fischetti, Daniel Jonathan Miklin, Alessandro Sarandrea, Valentina Schirripa, Fabrizio Guarracini, Arash Arya, Giorgio Loreni, Antonio Bruni, Stefano Rigattieri, Massimiliano Marini, Simone Vagnarelli, Germano Scevola, Bernhard Reimers, Gerhard Hindricks, Mauricio Cohen
BACKGROUND: Interventional radiology and cardiology procedures contribute significantly to the collective dose of radiation exposure from medical interventions. Recent and dedicated studies comparing directly these procedures in term of patient radiation exposure are lacking. Our aim was to compare radiation exposure among different interventional procedures performed under fluoroscopic guidance. METHODS: The RODEO study (NCT: 02972736) is an international observational retrospective multicenter study enrolling all patients undergoing diagnostic or interventional procedures performed by different interventional operators (i...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28315200/radiation-induced-cardiovascular-disease
#9
REVIEW
Deepa Raghunathan, Misha Iftikhar Khilji, Saamir A Hassan, Syed Wamique Yusuf
PURPOSE OF REVIEW: Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This review summarizes the pathology, incidence, clinical presentation, and management of cardiac events after radiation therapy. RECENT FINDINGS: Mediastinal radiation therapy accelerates the atherosclerosis process, resulting in early onset coronary artery disease...
May 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28315122/cardio-oncology-the-nuclear-option
#10
REVIEW
Jorge A Alvarez, Raymond R Russell
PURPOSE OF REVIEW: Cardio-oncology focuses increased effort to decrease cancer treatment-related cardiotoxicity while continuing to improve outcomes. We sought to synthesize the latest in nuclear cardiology as it pertains to the assessment of left ventricular function in preventative guidelines and comparison to other modalities, novel molecular markers of pre-clinical cardiotoxicity, and its role in cardiac amyloid diagnosis. RECENT FINDINGS: Planar ERNA (equilibrium radionuclide angiocardiography) provides a reliable and proven means of monitoring and preventing anthracycline cardiotoxicity, and SPECT ERNA using solid-state gamma cameras may provide reproducible assessments of left ventricular function with reduced radiation exposure...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28314613/improved-image-quality-with-simultaneously-reduced-radiation-exposure-knowledge-based-iterative-model-reconstruction-algorithms-for-coronary-ct-angiography-in-a-clinical-setting
#11
Florian André, Philipp Fortner, Mani Vembar, Dirk Mueller, Wolfram Stiller, Sebastian J Buss, Hans-Ulrich Kauczor, Hugo A Katus, Grigorios Korosoglou
BACKGROUND: The aim of this study was to assess the potential for radiation dose reduction using knowledge-based iterative model reconstruction (K-IMR) algorithms in combination with ultra-low dose body mass index (BMI)-adapted protocols in coronary CT angiography (coronary CTA). METHODS: Forty patients undergoing clinically indicated coronary CTA were randomly assigned to two groups with BMI-adapted (I: <25.0 kg/m(2), II: <28.0 kg/m(2), III: <30.0 kg/m(2), IV: ≥30...
February 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28301264/cardiac-events-after-radiation-therapy-combined-analysis-of-prospective-multicenter-trials-for-locally-advanced-non-small-cell-lung-cancer
#12
Robert T Dess, Yilun Sun, Martha M Matuszak, Grace Sun, Payal D Soni, Latifa Bazzi, Venkatesh L Murthy, Jason W D Hearn, Feng-Ming Kong, Gregory P Kalemkerian, James A Hayman, Randall K Ten Haken, Theodore S Lawrence, Matthew J Schipper, Shruti Jolly
Purpose Radiation therapy is a critical component in the care of patients with non-small-cell lung cancer (NSCLC), yet cardiac injury after treatment is a significant concern. Therefore, we wished to elucidate the incidence of cardiac events and their relationship to radiation dose to the heart. Patients and Materials Study eligibility criteria included patients with stage II to III NSCLC treated on one of four prospective radiation therapy trials at two centers from 2004 to 2013. All cardiac events were reviewed and graded per Common Terminology Criteria for Adverse Events (v4...
March 16, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28296296/biplane-interventional-pediatric-system-with-cone-beam-ct-dose-and-image-quality-characterization-for-the-default-protocols
#13
Eva Corredoira, Eliseo Vañó, Luis Alejo, Carlos Ubeda, Federico Gutiérrez-Larraya, Julia Garayoa
The aim of this study was to assess image quality and radiation dose of a biplane angiographic system with cone-beam CT (CBCT) capability tuned for pediatric cardiac procedures. The results of this study can be used to explore dose reduction techniques. For pulsed fluoroscopy and cine modes, polymethyl methacrylate phantoms of various thicknesses and a Leeds TOR 18-FG test object were employed. Various fields of view (FOV) were selected. For CBCT, the study employed head and body dose phantoms, Catphan 504, and an anthropomorphic cardiology phantom...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296294/electrocardiogram-gated-coronary-ct-angiography-dose-estimates-using-impact
#14
Masanao Kobayashi, Yasuki Asada, Kosuke Matsubara, Shouichi Suzuki, Kichiro Koshida, Yuta Matsunaga, Tomonobu Haba, Ai Kawaguchi, Hiroshi Toyama, Ryoichi Kato
The primary study objective was to assess radiation doses using a modified form of the Imaging Performance Assessment of Computed Tomography (CT) scanner (ImPACT) patient dosimetry for cardiac applications on an Aquilion ONE ViSION Edition scanner, including the Ca score, target computed tomography angiography (CTA), prospective CTA, continuous CTA/cardiac function analysis (CFA), and CTA/CFA modulation. Accordingly, we clarified the CT dose index (CTDI) to determine the relationship between heart rate (HR) and X-ray exposure...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295547/practitioner-perceptions-of-the-anesthetic-needs-for-magnetic-resonance-imaging-in-pediatric-patients
#15
Glenn E Mann, Adam Canter, Singh Nair, Donna LaMonica, Madelyn Kahana, Jennifer Yoo, Ellise Delphin
There is currently an increasing use of magnetic resonance imaging (MRI) as a diagnostic tool in the pediatric population(1). MRI is often viewed as an ideal diagnostic modality because it does not require exposure to ionizing radiation, provides superior soft tissue image quality compared with computed tomography (CT) and is thus well-suited for neurological, musculoskeletal, cardiac, thoracic, and abdominal studies(2). However, MRIs require patient cooperation and extended time periods of immobility, as the studies are often long, loud, and may induce claustrophobia (2-7)...
March 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28295525/advantages-and-pitfalls-of-pocket-ultrasound-vs-daily-chest-radiography-in-the-coronary-care-unit-a-single-user-experience
#16
Colin T Phillips, Warren J Manning
BACKGROUND: Pocket ultrasonography may enhance patient diagnosis and care. We sought to assess pocket ultrasound in detecting common conditions in the coronary care unit (CCU) compared to portable daily chest radiography (CXR) and conventional transthoracic echocardiography (TTE). METHODS: An experienced pocket ultrasound user performed a pocket ultrasound examination for interstitial edema, pneumonia, central line seen in the right ventricle, pleural and pericardial effusions, left atrial enlargement, and cardiomegaly...
March 14, 2017: Echocardiography
https://www.readbyqxmd.com/read/28289524/assessment-of-stable-coronary-artery-disease-by-cardiovascular-magnetic-resonance-imaging-current-and-emerging-techniques
#17
REVIEW
James R J Foley, Sven Plein, John P Greenwood
Coronary artery disease (CAD) is a leading cause of death and disability worldwide. Cardiovascular magnetic resonance (CMR) is established in clinical practice guidelines with a growing evidence base supporting its use to aid the diagnosis and management of patients with suspected or established CAD. CMR is a multi-parametric imaging modality that yields high spatial resolution images that can be acquired in any plane for the assessment of global and regional cardiac function, myocardial perfusion and viability, tissue characterisation and coronary artery anatomy, all within a single study protocol and without exposure to ionising radiation...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28288480/the-effect-of-heart-rate-on-exposure-window-and-best-phase-for-stress-perfusion-computed-tomography-lessons-from-the-core320-study
#18
Chloe Steveson, Joanne D Schuijf, Andrea L Vavere, Richard T Mather, Teresa Caton, Vishal Mehra, Aisha Betoko, Christopher Cox, Joao Ac Lima, Richard T George
OBJECTIVES: The aim of this study is to evaluate the effect of heart rate on exposure window, best phase, and image quality for stress computed tomography perfusion (CTP) in the CORE320 study. METHODS: The CTP data sets were analyzed to determine the best phase for perfusion analysis. A predefined exposure window covering 75% to 95% of the R-R cycle was used. RESULTS: Of the 368 patients included in the analysis, 93% received oral β blockade before the rest scan...
March 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28287916/the-effect-of-contrast-medium-on-radiation-dose-in-ct-part-ii-a-systematic-evaluation-across-58-patient-models
#19
Pooyan Sahbaee, Ehsan Abadi, W Paul Segars, Daniele Marin, Rendon C Nelson, Ehsan Samei
Purpose To estimate the radiation dose as a result of contrast medium administration in a typical abdominal computed tomographic (CT) examination across a library of contrast material-enhanced computational patient models. Materials and Methods In part II of this study, first, the technique described in part I of this study was applied to enhance the extended cardiac-torso models with patient-specific iodine-time profiles reflecting the administration of contrast material. Second, the patient models were deployed to assess the patient-specific organ dose as a function of time in a typical abdominal CT examination using Monte Carlo simulation...
March 13, 2017: Radiology
https://www.readbyqxmd.com/read/28283317/pilot-study-to-determine-the-feasibility-of-radiation-therapy-for-dogs-with-right-atrial-masses-and-hemorrhagic-pericardial-effusion
#20
M W Nolan, M M Arkans, D LaVine, T DeFrancesco, J A Myers, E H Griffith, L P Posner, B W Keene, S P Tou, T L Gieger
OBJECTIVES: To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs. ANIMALS: Six dogs with echocardiographic evidence of a right atrial/auricular mass, and hemorrhagic pericardial effusion, were enrolled in a prospective, single-arm clinical trial. METHODS: A single fraction of 12 Gy was delivered using conformal external beam irradiation. Serum cardiac troponin I and plasma concentrations of vascular endothelial growth factor were quantified before, 4 and 24 h after RT...
March 7, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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