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Cardiac radiation

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https://www.readbyqxmd.com/read/28109921/coronary-artery-pet-mr-imaging-feasibility-limitations-and-solutions
#1
Philip M Robson, Marc R Dweck, Maria Giovanna Trivieri, Ronan Abgral, Nicolas A Karakatsanis, Johanna Contreras, Umesh Gidwani, Jagat P Narula, Valentin Fuster, Jason C Kovacic, Zahi A Fayad
OBJECTIVES: The aims of this study were to describe the authors' initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using (18)F-fluorodeoxyglucose ((18)F-FDG) and (18)F-sodium fluoride ((18)F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients. BACKGROUND: Recently, PET imaging has been applied to the aortic valve and regions of atherosclerosis...
January 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28100220/effect-of-patient-s-age-on-the-profitability-of-inpatient-cardiac-catheterization-a-contribution-margin-analysis-of-frequently-performed-procedures-over-a-5-year-period
#2
Gunnar Plehn, Thomas Butz, Petra Maagh, Axel Meissner
BACKGROUND: Due to a continuing age shift in the German society hospital providers are concerned about the additional costs associated with the treatment of elderly patients. It is not clear if cardiac catheterization in aged patients leads to higher resource utilization and if DRG-revenues do compensate for this factor. METHODS: Procedure-related and administrative data of all patients who underwent cardiac catheterization at a tertiary heart center between 2007 and 2011 were collected and analyzed...
January 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28098222/dose-dependency-and-reversibility-of-radiation-induced-injury-in-cardiac-explant-derived-cells-of-mice
#3
Lan Luo, Chen Yan, Yoshishige Urata, Al Shaimaa Hasan, Shinji Goto, Chang-Ying Guo, Shouhua Zhang, Tao-Sheng Li
We evaluated the dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells (CDCs), a mixed cell population grown from heart tissues. Adult C57BL/6 mice were exposed to 0, 10, 50 and 250 mGy γ-rays for 7 days and atrial tissues were collected for experiments 24 hours after last exposure. The number of CDCs was significantly decreased by daily exposure to over 250 mGy. Interestingly, daily exposure to over 50 mGy significantly decreased the c-kit expression and telomerase activity, increased 53BP1 foci in the nuclei of CDCs...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096044/use-of-transesophageal-echocardiography-and-contrast-echocardiography-in-the-evaluation-of-cardiac-masses
#4
Hongmei Xia, Ling Gan, Yan Jiang, Qi Tang, Ping Zhang, Xuefeng Tang, Li Wen, Zheng Liu, Yunhua Gao
OBJECTIVES: To determine whether the combination of transesophageal echocardiography (TEE) and contrast echocardiography (CE) accurately diagnose suspected cardiac masses using large sample data. METHODS: Patients with cardiac masses undergoing surgical treatment were enrolled in this study. Routine transthoracic echocardiography (TTE) and TEE examinations were carried out, and CE examinations were carried out when needed. All patients' clinical data and imaging features were retrospectively reviewed...
January 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28095159/validation-and-modification-of-a-prediction-model-for-acute-cardiac-events-in-patients-with-breast-cancer-treated-with-radiotherapy-based-on-three-dimensional-dose-distributions-to-cardiac-substructures
#5
Veerle A B van den Bogaard, Bastiaan D P Ta, Arjen van der Schaaf, Angelique B Bouma, Astrid M H Middag, Enja J Bantema-Joppe, Lisanne V van Dijk, Femke B J van Dijk-Peters, Laurens A W Marteijn, Gertruida H de Bock, Johannes G M Burgerhof, Jourik A Gietema, Johannes A Langendijk, John H Maduro, Anne P G Crijns
Purpose A relationship between mean heart dose (MHD) and acute coronary event (ACE) rate was reported in a study of patients with breast cancer (BC). The main objective of our cohort study was to validate this relationship and investigate if other dose-distribution parameters are better predictors for ACEs than MHD. Patients and Methods The cohort consisted of 910 consecutive female patients with BC treated with radiotherapy (RT) after breast-conserving surgery. The primary end point was cumulative incidence of ACEs within 9 years of follow-up...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28095022/estimating-effective-dose-of-radiation-from-pediatric-cardiac-ct-angiography-using-a-64-mdct-scanner-new-conversion-factors-relating-dose-length-product-to-effective-dose
#6
Sigal Trattner, Anjali Chelliah, Peter Prinsen, Carrie B Ruzal-Shapiro, Yanping Xu, Sachin Jambawalikar, Maxwell Amurao, Andrew J Einstein
OBJECTIVE: The purpose of this study is to determine the conversion factors that enable accurate estimation of the effective dose (ED) used for cardiac 64-MDCT angiography performed for children. MATERIALS AND METHODS: Anthropomorphic phantoms representative of 1- and 10-year-old children, with 50 metal oxide semiconductor field-effect transistor dosimeters placed in organs, underwent scanning performed using a 64-MDCT scanner with different routine clinical cardiac scan modes and x-ray tube potentials...
January 17, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28092496/the-effect-of-contrast-material-on-radiation-dose-at-ct-part-i-incorporation-of-contrast-material-dynamics-in-anthropomorphic-phantoms
#7
Pooyan Sahbaee, W Paul Segars, Daniele Marin, Rendon C Nelson, Ehsan Samei
Purpose To develop a method to incorporate the propagation of contrast material into computational anthropomorphic phantoms for estimation of organ dose at computed tomography (CT). Materials and Methods A patient-specific physiologically based pharmacokinetic (PBPK) model of the human cardiovascular system was incorporated into 58 extended cardiac-torso (XCAT) patient phantoms. The PBPK model comprised compartmental models of vessels and organs unique to each XCAT model. For typical injection protocols, the dynamics of the contrast material in the body were described according to a series of patient-specific iodine mass-balance differential equations, the solutions to which provided the contrast material concentration time curves for each compartment...
January 13, 2017: Radiology
https://www.readbyqxmd.com/read/28089778/image-noise-reduction-technology-reduces-radiation-in-a-radial-first-cardiac-catheterization-laboratory
#8
Ateka Gunja, Yagya Pandey, Hui Xie, Beata M Wolska, Adhir R Shroff, Amer K Ardati, Mladen I Vidovich
BACKGROUND: Transradial coronary angiography (TRA) has been associated with increased radiation doses. We hypothesized that contemporary image noise reduction technology would reduce radiation doses in the cardiac catheterization laboratory in a typical clinical setting. METHODS AND RESULTS: We performed a single-center, retrospective analysis of 400 consecutive patients who underwent diagnostic and interventional cardiac catheterizations in a predominantly TRA laboratory with traditional fluoroscopy (N=200) and a new image noise reduction fluoroscopy system (N=200)...
December 27, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28081128/radiation-exposure-from-diagnostic-imaging-in-a-cohort-of-pediatric-transplant-recipients
#9
Alexandra Seal, Michael Hawkes, Ravi Bhargava, Michelle Noga, Jutta Preiksaitis, Curtis Mabilangan, Joan Robinson
Recipients of solid organ transplants (SOT) have extensive diagnostic imaging (DI). The purpose of this study was to quantify this exposure. Children from northern Alberta with SOTs at Stollery Children's Hospital, Edmonton, Alberta January 1, 2006, to July 31, 2012, were included. Effective doses of radiation were estimated using published norms for DI performed post-transplant up to October 16, 2014. The 54 eligible children had 6215 DI studies (5628 plain films, 293 computerized tomography (CT) scans, 149 positron emission topography (PET) -CT scans, 47 nuclear medicine scans and 98 cardiac catheterizations)...
2017: PloS One
https://www.readbyqxmd.com/read/28068237/reassessing-the-time-course-for-radiation-induced-cardiac-mortality-in-patients-with-breast-cancer
#10
Lawrence B Marks, Timothy M Zagar, Orit Kaidar-Person
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28054837/radiosurgery-alters-the-endothelial-surface-proteome-externalized-intracellular-molecules-as-potential-vascular-targets-in-irradiated-brain-arteriovenous-malformations
#11
Lucinda S McRobb, Vivienne S Lee, Margaret Simonian, Zhenjun Zhao, Santhosh George Thomas, Markus Wiedmann, Jude V Amal Raj, Michael Grace, Vaughan Moutrie, Matthew J McKay, Mark P Molloy, Marcus A Stoodley
Stereotactic radiosurgery (SRS) is an established treatment for brain arteriovenous malformations (AVMs) that drives blood vessel closure through cellular proliferation, thrombosis and fibrosis, but is limited by a delay to occlusion of 2-3 years and a maximum treatable size of 3 cm. In this current study we used SRS as a priming tool to elicit novel protein expression on the endothelium of irradiated AVM vessels, and these proteins were then targeted with prothrombotic conjugates to induce rapid thrombosis and vessel closure...
January 5, 2017: Radiation Research
https://www.readbyqxmd.com/read/28052027/estrogen-receptor-%C3%AE-ligation-inhibits-hodgkin-lymphoma-growth-by-inducing-autophagy
#12
Marina Pierdominici, Angela Maselli, Silvia L Locatelli, Laura Ciarlo, Giuseppa Careddu, Mario Patrizio, Barbara Ascione, Antonella Tinari, Carmelo Carlo-Stella, Walter Malorni, Paola Matarrese, Elena Ortona
Although Hodgkin lymphoma (HL) is curable with current therapy, at least 20% of patients relapse or fail to make complete remission. In addition, patients who achieve long-term disease-free survival frequently undergo infertility, secondary malignancies, and cardiac failure, which are related to chemotherapeutic agents and radiation therapies. Hence, new therapeutic strategies able to counteract the HL disease in this important patient population are still a matter of study. Estrogens, in particular 17β-estradiol (E2), have been suggested to play a role in lymphoma cell homeostasis by estrogen receptors (ER) β activation...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28048767/su-f-i-77-radiation-dose-in-cardiac-catheterization-procedures-impact-of-a-systematic-reduction-in-pulsed-fluoroscopy-frame-rate
#13
C Schultz, S Dixon
PURPOSE: To evaluate whether one small systematic reduction in fluoroscopy frame rate has a significant effect on the total air kerma and/or dose area product for diagnostic and interventional cardiac catheterization procedures. METHODS: The default fluoroscopy frame rate (FFR) was lowered from 15 to 10 fps in 5 Siemens™ Axiom Artis cardiac catheterization labs (CCL) on July 1, 2013. A total of 7212 consecutive diagnostic and interventional CCL procedures were divided into two study groups: 3602 procedures from 10/1/12 -6/30/13 with FFR of 15 fps; and 3610 procedures 7/1/13 - 3/31/14 at 10 fps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048739/tu-ab-207a-03-image-quality-dose-and-clinical-applications
#14
F Dong
: Practicing medical physicists are often time charged with the tasks of evaluating and troubleshooting complex image quality issues related to CT scanners. This course will equip them with a solid and practical understanding of common CT imaging chain and its major components with emphasis on acquisition physics and hardware, reconstruction, artifacts, image quality, dose, and advanced clinical applications. The core objective is to explain the effects of these major system components on the image quality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048692/mo-fg-207b-01-thorax-lung
#15
H Aerts
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048400/th-b-207b-00-pediatric-image-quality-optimization
#16
Christina Sammet
: This imaging educational program will focus on solutions to common pediatric image quality optimization challenges. The speakers will present collective knowledge on best practices in pediatric imaging from their experience at dedicated children's hospitals. One of the most commonly encountered pediatric imaging requirements for the non-specialist hospital is pediatric CT in the emergency room setting. Thus, this educational program will begin with optimization of pediatric CT in the emergency department...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048247/we-fg-202-10-assessing-hepatocellular-carcinoma-hcc-response-to-sbrt-using-dce-mri
#17
Y Yuan, M Buckstein, M Chao, K Rosenzweig, Y Lo
PURPOSE: To investigate the feasibility of using DCE-MRI to assess treatment response of HCC to SBRT. METHODS: For seven liver HCC patients treated by photon SBRT with radiation dose ranging from 35 to 50 Gy in 5 fractions, T1-weighted DCE-MRI was performed before and at 1-3 months after the treatment. Each study included one pre-contrast and five post Gd-EOB-DTPA-enhanced imaging series. The target tumor and the liver were manually outlined on the arterial phase images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048031/mo-fg-207b-02-breast
#18
H Li
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048020/tu-ab-207a-00-ct-systems-course
#19
Baojun Li
: Practicing medical physicists are often time charged with the tasks of evaluating and troubleshooting complex image quality issues related to CT scanners. This course will equip them with a solid and practical understanding of common CT imaging chain and its major components with emphasis on acquisition physics and hardware, reconstruction, artifacts, image quality, dose, and advanced clinical applications. The core objective is to explain the effects of these major system components on the image quality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047965/tu-h-campus-jep2-05-can-automatic-delineation-of-cardiac-substructures-on-noncontrast-ct-be-used-for-cardiac-toxicity-analysis
#20
Y Luo, Z Liao, W Jiang, D Gomez, R Williamson, L Court, J Yang
PURPOSE: To evaluate the feasibility of using an automatic segmentation tool to delineate cardiac substructures from computed tomography (CT) images for cardiac toxicity analysis for non-small cell lung cancer (NSCLC) patients after radiotherapy. METHODS: A multi-atlas segmentation tool developed in-house was used to delineate eleven cardiac substructures including the whole heart, four heart chambers, and six greater vessels automatically from the averaged 4DCT planning images for 49 NSCLC patients...
June 2016: Medical Physics
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