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https://www.readbyqxmd.com/read/29144817/seasonal-variation-of-vitamin-d-and-serum-thyrotropin-levels-and-its-relationship-in-a-euthyroid-caucasian-population
#1
Gautam Das, Peter N Taylor, Heather Javaid, Brian P Tennant, John Geen, Andrew Aldridge, Onyebuchi Okosieme
OBJECTIVES: It is unclear whether seasonal variations in vitamin D concentrations affect the hypothalamo-pituitary-thyroid (HPT) axis. We investigated the seasonal variability of vitamin D and serum thyrotropin (TSH) levels and their inter-relationship. METHODS: Analysis of 401 patients referred with non-specific symptoms of tiredness who had simultaneous measurements of 25(OH)D3 and thyroid function. Patients were categorised according to the season of blood sampling and their vitamin D status...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29115448/mapks-and-nf%C3%A2-%C3%AE%C2%BAb-pathway-inhibitory-effect-of-bisdemethoxycurcumin-on-phorbol%C3%A2-12%C3%A2-myristate%C3%A2-13%C3%A2-acetate-and-a23187%C3%A2-induced-inflammation-in-human-mast-cells
#2
Ryong Kong, Ok-Hwa Kang, Yun-Soo Seo, Tian Zhou, Sang-A Kim, Dong-Won Shin, Dong-Yeul Kwon
Inflammation‑associated damage may occur in any tissue following infection, exposure to toxins, following ischemia, and in allergic and auto‑immune reactions. Inflammation may also result from mast cell degranulation induced by the intracellular calcium concentration. The inflammatory process may be inhibited by compounds that affect mast cells. Bisdemethoxycurcumin [1,7‑bis(4‑hydroxyphenyl) hepta‑1,6‑diene‑3,5‑dione, BDCM] is the active component of turmeric. It has anticancer, antioxidant and antibacterial properties...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29107664/eruption-of-lymphocyte-recovery-with-atypical-lymphocytes-mimicking-a-primary-cutaneous-t-cell-lymphoma-a-series-of-12-patients
#3
Charlotte Hurabielle, Emilie Sbidian, Helmut Beltraminelli, Brigitte Bouchindhomme, Catherine Chassagne-Clément, Brigitte Balme, Céline Bossard, Marie-Hélène Delfau-Larue, Pierre Wolkenstein, Olivier Chosidow, Catherine Cordonnier, Andrea Toma, Cécile Pautas, Nicolas Ortonne
Eruption of lymphocyte recovery (ELR) may occur during bone marrow aplasia after chemotherapies. We reviewed the clinical and pathologic features of 12 patients (male/female: 7/5, median age: 61years) with an atypical ELR histologically mimicking a primary cutaneous T-cell lymphoma (CTCL) such as Sézary Syndrome or CD30+ T-cell lymphoproliferative disorder (LPD). All the patients displayed an erythematous maculopapular eruption on the trunk and the limbs, associated with fever. All but one had received a polychemotherapy for an acute myeloid leukemia (n=10) or an urothelial carcinoma (n=1) before the occurrence of the skin eruption...
October 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/29096830/serum-of-patients-with-antiphospholipid-syndrome-induces-adhesion-molecules-in-endothelial-cells
#4
Bettina Engel, Gregor Müller, Beate Roch, Hans-Egbert Schröder, Martin Aringer, Stefan R Bornstein, Henning Morawietz
OBJECTIVE: The antiphospholipid syndrome (APS) is a systemic auto-immune disease with an unclear pathophysiology. The aim of our study was to understand the development of APS on a cellular level. Therefore, we analyzed the influence of human serum of APS patients on endothelial expression of specific genes and proteins in comparison to a control group. METHODS: In this study, we analyzed the expression of ICAM-1, VCAM-1, E-selectin and annexin V in primary cultures of human umbilical vein endothelial cells (HUVEC) in response to 10% (v/v) serum of control patients (n = 6), patients with systemic lupus erythematosus (SLE) and no APS (n = 4) or APS patients (n = 9) for 24 h...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29091929/the-cathelicidin-protein-cramp-is-a-potential-atherosclerosis-self-antigen-in-apoe-mice
#5
Peter M Mihailovic, Wai Man Lio, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Kuang-Yuh Chyu, Prediman K Shah, Bojan Cercek, Paul C Dimayuga
Auto-immunity is believed to contribute to inflammation in atherosclerosis. The antimicrobial peptide LL-37, a fragment of the cathelicidin protein precursor hCAP18, was previously identified as an autoantigen in psoriasis. Given the reported link between psoriasis and coronary artery disease, the biological relevance of the autoantigen to atherosclerosis was tested in vitro using a truncated (t) form of the mouse homolog of hCAP18, CRAMP, on splenocytes from athero-prone ApoE(-/-) mice. Stimulation with tCRAMP resulted in increased CD8+ T cells with Central Memory and Effector Memory phenotypes in ApoE(-/-) mice, differentially activated by feeding with normal chow or high fat diet...
2017: PloS One
https://www.readbyqxmd.com/read/29080553/comprehensive-approach-to-study-complement-c4-in-systemic-lupus-erythematosus-gene-polymorphisms-protein-levels-and-functional-activity
#6
M W P Tsang-A-Sjoe, I E M Bultink, L A Korswagen, A van der Horst, I Rensink, M de Boer, D Hamann, A E Voskuyl, D Wouters
Genetic variation of the genes encoding complement component C4 is strongly associated with systemic lupus erythematosus (SLE), a chronic multi-organ auto-immune disease. This study examined C4 and its isotypes on a genetic, protein, and functional level in 140 SLE patients and 104 healthy controls. Gene copy number (GCN) variation, silencing CT-insertion, and the retroviral HERV-K(C4) insertion) were analyzed with multiplex ligation-dependent probe amplification. Increased susceptibility to SLE was found for low GCN (≪2) of C4A...
October 25, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29077480/social-emotional-aspects-of-quality-of-life-in-multiple-sclerosis
#7
Heidemarie Lex, Sara Weisenbach, Jacob Sloane, Sana Syed, Eva Rasky, Wolfgang Freidl
Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system. It leads to many impairments including physical, cognitive, psychological, and social challenges. Our study examined gender and cultural associations with quality of life (QoL), personal characteristics, and benefits from having MS among those with MS. The study was conducted in Austria and the United States. The sample included 128 participants, 64 in each country, of whom 78 were women and 50 were men aged between 20 and 57 years...
October 27, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29065233/-chronic-inflammatory-demyelinating-polyradiculoneuropathy-clinical-aspects-and-new-animal-models-of-auto-immunity-to-nodal-components
#8
Isabel Illa
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic and treatable disorder of the peripheral nerves with clinical and immunological heterogeneity.
October 24, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29055475/neuromyelitis-optica-spectrum-disorder-mimicking-multiple-sclerosis
#9
Lucas C van Rooij, Mike P Wattjes, Brigit A de Jong, Bob W van Oosten
BACKGROUND: MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. OBJECTIVE: Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29050651/-movement-disorders-an-update
#10
M Béreau, C Tranchant
Movement disorders (tremor, chorea, dystonia, tics, and myoclonus) are related to basal ganglia and/or interconnected brain areas dysfunction. Clinical examination is a key point in order to characterize the abnormal movement and identify associated signs that can guide etiological approach. Iatrogenic diseases will be systematically ruled out before conducting additional investigations (brain MRI, electrophysiological studies). Wilson disease, but also other treatable metabolic and/or genetic diseases, and auto-immune diseases will be systematically considered...
October 16, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29045188/rapid-evolution-of-thyroid-dysfunction-in-patients-treated-with-nivolumab
#11
Grenye O'Malley, Hanna J Lee, Samir Parekh, Matthew D Galsky, Cardinale B Smith, Philip Friedlander, Robert T Yanagisawa, Emily J Gallagher
OBJECTIVE: To describe the evolution of thyroid dysfunction in a series of patients with cancer treated with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) monoclonal antibody, nivolumab. METHODS: Cases of thyroid dysfunction after initiation of checkpoint inhibitor treatment were identified from the Division of Endocrinology clinical practice at Mount Sinai Hospital, New York from April 2016 to February 2017. Charts were reviewed to identify patients treated with nivolumab with new onset of thyroid dysfunction...
October 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29028829/sodium-excretion-is-higher-in-patients-with-rheumatoid-arthritis-than-in-matched-controls
#12
Sarah Marouen, Guilhem du Cailar, Rachel Audo, Cedric Lukas, Gaelle Vial, Anne Tournadre, Emmanuel Barrat, Jean Ribstein, Bernard Combe, Jacques Morel, Claire I Daien
OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849±1,350 vs...
2017: PloS One
https://www.readbyqxmd.com/read/28990564/-mirnas-new-actors-in-the-physiopathology-of-multiple-sclerosis
#13
Ferdinand Jagot, Nathalie Davoust
Multiple sclerosis (MS) is an auto-immune demyelinating disorder characterized by a chronic neuro-inflammatory process associated with an infiltration of the central nervous system (CNS) by autoreactive lymphocytes. The etiology of the disease remains unclear but the recent discovery of a dysregulated miRNA network in both cells and extracellular fluids of MS patients has brought new insights on the pathophysiological mechanisms involved in this disorder. miRNAs can induce a T cell polarization towards a pathological Th17 or Th1 phenotype and a deleterious activation of microglia, the CNS-resident macrophages...
June 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28979622/-vitiligo-revealing-vogt-koyanagi-harada-disease
#14
Mohamed El Amraoui, Youssef Zemmez, Ahmed Bouhamidi, Rachid Frikh, Naoufal Hjira, Mohammed Boui
Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28977749/chemical-approaches-to-modulating-complement-mediated-diseases
#15
Abishek Iyer, Weijun Xu, Robert C Reid, David P Fairlie
Numerous diseases are driven by chronic inflammation, placing major burdens on our health systems. Controlling inflammation is an important preventative and therapeutic goal. Over forty 'Complement' proteins are produced in blood or on cell surfaces through activation of the Complement protein network by infection or injury. These proteins complement immune cells and antibodies to identify, tag, destroy and eliminate pathogens and infected or damaged cells, and repair tissues. If the inflammatory stimulus is not removed by localized acute immune responses, Complement activation may be prolonged or misdirected to healthy cells, and chronic inflammation can lead to inflammatory or auto-immune diseases...
October 4, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28971103/towards-developing-a-vaccine-for-rheumatic-heart-disease
#16
REVIEW
Geethanjali Devadoss Gandhi, Navaneethakrishnan Krishnamoorthy, Ussama M Abdel Motal, Magdi Yacoub
Rheumatic heart disease (RHD) is the most serious manifestations of rheumatic fever, which is caused by group A Streptococcus (GAS or Streptococcus pyogenes) infection. RHD is an auto immune sequelae of GAS pharyngitis, rather than the direct bacterial infection of the heart, which leads to chronic heart valve damage. Although antibiotics like penicillin are effective against GAS infection, improper medical care such as poor patient compliance, overcrowding, poverty, and repeated exposure to GAS, leads to acute rheumatic fever and RHD...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28971075/relationship-between-sleep-pain-and-inflammatory-markers-in-patients-with-rheumatoid-arthritis
#17
Majid Purabdollah, Sima Lakdizaji, Azad Rahmani
Introduction: Rheumatoid Arthritis (RA) is known as a progressive chronic auto-immune disease. Measurement of inflammatory markers are applied for follow up the activity of disease. So determining factors that effects these markers such as sleep and pain can help to prevent the severity of disease. The aim of study was to determine the relationship between sleep disorders, pain and inflammatory markers in patients with RA. Methods: Participants included 210 patients with RA referred to educational medical clinics of Imam Reza and Sina in Tabriz selected by convenience sampling...
September 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28969235/super-refractory-status-epilepticus-a-therapeutic-challenge-in-paediatrics
#18
Shrikiran Aroor, Kanaparthi Shravan, Suneel C Mundkur, C Jayakrishnan, Sai Sripad Rao
A status epilepticus which persists for 24 hours or more after starting treatment with anaesthesia or has recurred inspite of general anaesthesia is known as Super-Refractory Status Epilepticus (SRSE). It includes cases where status epilepticus recurs on reduction or withdrawal of anaesthesia. SRSE, though infrequently seen, constitutes a medical emergency due to the associated high morbidity and mortality. No clear cut guidelines are available till date for the management of SRSE. Most of the published literature was case reports and expert opinion...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969181/a-rare-cause-of-anaemia-in-hiv-aids
#19
Samarth Virmani, Rama Bhat, Raghavendra Rao, Ruchee Khanna, Lipisha Agarwal
Patients living with HIV are commonly diagnosed with anaemia which can have various aetiologies. However, one of the rare causes of anaemia in such patients is Auto Immune Haemolytic Anaemia (AIHA), which is difficult to diagnose due to the absence of reticulocytosis in HIV patients. Such patients can be treated with corticosteroids which can gradually be tapered off over a period of time. The following is a case of a 52-year-old male living with HIV who was diagnosed to have AIHA and was successfully treated with steroids...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28961019/damage-associated-molecular-patterns-and-their-role-as-initiators-of-inflammatory-and-auto-immune-signals-in-systemic-lupus-erythematosus
#20
Karen Álvarez, Gloria Vasquez
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce inflammation and immune responses in the absence of infection. An increasing number of DAMPs have been linked to the pathogenesis of many auto-immune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis, and systemic sclerosis (SSc); as they promote the maturation/activation of different immune cells and pro-inflammatory cytokines production associated with these diseases...
September 3, 2017: International Reviews of Immunology
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