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https://www.readbyqxmd.com/read/28209906/first-evaluation-of-pet-based-human-biodistribution-and-dosimetry-of-18-f-faza-a-tracer-for-imaging-tumor-hypoxia
#1
Savi Annarita, Elena Incerti, Federico Fallanca, Valentino Bettinardi, Francesca Rossetti, Cristina Monterisi, Antonia Compierchio, Giampiero Negri, Piero Zannini, Luigi Gianolli, Maria Picchio
Fluorine-18 labelled fluoroazomycinarabinoside ((18)F-FAZA) is a positron emission tomography (PET) biomarker for non-invasive identification of regional tumor hypoxia. Aim of the present Phase I study was to firstly evaluate in non-small cell lung cancer patients the human biodistribution and dosimetry of (18)F-FAZA. Methods: Five patients awaiting surgical resection after histologically proven or radiologically suspected non-small cell lung cancer were prospectively enrolled for the study. The patients underwent a PET/computed tomography (CT) study after the injection of 371±32 MBq of (18)F-FAZA...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28193134/non-coronary-vascular-calcification-bone-mineral-density-and-muscle-mass-in-institutionalized-frail-nonagenarians
#2
Fernando Idoate, Eduardo L Cadore, Alvaro Casas-Herrero, Fabricio Zambom-Ferraresi, Nicolas Martinez-Velilla, Leocadio Rodriguez-Mañas, Pedro M Azkarate, Martim Bottaro, Robison Ramírez-Vélez, Mikel Izquierdo
The purpose of this study was to compare the vascular calcification at thoracic (TAC) and ab-dominal (AAC) aorta, iliac (IAC) and femoral (FAC) arteries, and bone mineral density (BMD) of the lumbar vertebrae between frail and robust nonagenarians, as well as to verify the associations between vascular calcification with BMD, muscle tissue quality and quantity in both groups. Forty-two elderly subjects participated in this study: 29 institutionalized frail (92.0±3.2 years) and 13 ro-bust (89.0±4.0 years) elderly participants...
February 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28183279/three-dimensional-comparison-of-intramuscular-fat-content-between-young-and-old-adults
#3
Akito Yoshiko, Maya Hioki, Nana Kanehira, Kiyoshi Shimaoka, Teruhiko Koike, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima
BACKGROUND: Fat infiltration within skeletal muscle is known as intramuscular fat (IMF), which increases with aging. Studies have assessed IMF content, using the mid-thigh as a representative location. However, three-dimensional IMF distribution is not well understood. The aim of this study was to compare the IMF content in young and old adults by assessing its distribution along the length of the thigh. METHODS: Consecutive transaxial images of the right thighs in 15 young (age, 21...
February 10, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28174660/mrgfus-for-desmoid-tumors-within-the-thigh-early-clinical-experiences
#4
Matthew D Bucknor, Viola Rieke
BACKGROUND: Desmoid tumors are benign but locally aggressive non-malignant tumors derived from fibroblasts. Surgery, chemotherapy, and radiation therapy have been the mainstay of treatment, but recurrence is common and side effects can result in significant morbidity. In this case series, we highlight our experiences performing treatments in the thigh, including strategies for optimizing ablation size and safety. CASE PRESENTATION: Since December 2014, 14 magnetic resonance-guided focused ultrasound (MRgFUS) treatments for desmoid tumors were performed at our institution in seven patients...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28160398/failed-percutaneous-vertebroplasty-due-to-insufficient-correction-of-intravertebral-instability-in-kummell-s-disease-a-case-report
#5
Jung Eun Kim, Sang Sik Choi, Mi Kyoung Lee, Dong Kyu Lee, Seung Inn Cho
Kummell's disease, caused by osteonecrosis of the vertebral body, is a cause of vertebral collapse. In Kummell's disease, intravertebral instability from non-union between the cement and bone after percutaneous vertebroplasty (PVP) can cause persistent severe pain and dysfunction. A 75-year-old woman presented with severe pain in the lower back, both buttocks, groin, and both posterior thighs for a period of 30 days. Lumbar radiographs and magnetic resonance images showed an acute compression fracture of the first lumbar vertebra with an intravertebral cleft filled with fluid...
February 3, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28153563/perforator-free-flaps-in-head-and-neck-reconstruction-a-single-center-low-volume-experience
#6
Annelies Weckx, Natalie Loomans, Olivier Lenssen
OBJECTIVE: The aim of this article is to investigate the results of free-flap reconstructions in the head and neck area in a secondary low-volume institution and compare these with the literature. STUDY DESIGN: A retrospective study was performed of all patients who underwent free-flap reconstructive surgery in our institution from January 9, 2011, to July 12, 2015, by one young surgeon in a one-team approach. The types of flaps applied, defect sites, pathology, anastomotic details, success and complication rates, lengths of stay, and patients' ages and comorbidities were analyzed...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28150324/sonographic-evaluation-of-fetal-adrenal-gland-in-gestational-diabetes-relation-to-fetal-growth-and-maternal-biochemical-markers
#7
Jose Garcia-Flores, Mireia Cruceyra, Marina Cañamares, Ainhoa Garicano, Mercedes Espada, Olga Nieto, Ines Tamarit, Ricardo Sainz de la Cuesta
OBJECTIVES: To relate measurements and volume of the fetal adrenal gland in third trimester ultrasound in diabetic pregnancies (1) to birth weight; (2) to other sonographic markers of diabetic fetopathy (expected fetal weight, sectional area, and fractional volume in fetal limbs); and (3) to maternal biochemical markers of diabetes (HbA1c, leptin). METHODS: Fetal adrenal gland measurements were obtained between 32 and 34 weeks. The gland length, width, depth, and volume (by Virtual Organ Computer-Aided Analysis [VOCAL]) were measured for total gland and fetal zone...
February 2, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28141810/validation-of-blood-volume-fraction-quantification-with-3d-gradient-echo-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-porcine-skeletal-muscle
#8
Stefan Hindel, Anika Söhner, Marc Maaß, Wolfgang Sauerwein, Dorothe Möllmann, Hideo Andreas Baba, Martin Kramer, Lutz Lüdemann
The purpose of this study was to assess the accuracy of fractional blood volume (vb) estimates in low-perfused and low-vascularized tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The results of different MRI methods were compared with histology to evaluate the accuracy of these methods under clinical conditions. vb was estimated by DCE-MRI using a 3D gradient echo sequence with k-space undersampling in five muscle groups in the hind leg of 9 female pigs. Two gadolinium-based contrast agents (CA) were used: a rapidly extravasating, extracellular, gadolinium-based, low-molecular-weight contrast agent (LMCA, gadoterate meglumine) and an extracellular, gadolinium-based, albumin-binding, slowly extravasating blood pool contrast agent (BPCA, gadofosveset trisodium)...
2017: PloS One
https://www.readbyqxmd.com/read/28122635/comparative-analyses-of-muscle-mri-and-muscular-function-in-anti-synthetase-syndrome-patients-and-matched-controls-a-cross-sectional-study
#9
Helena Andersson, Eva Kirkhus, Torhild Garen, Ragnhild Walle-Hansen, Else Merckoll, Øyvind Molberg
BACKGROUND: Magnetic resonance imaging (MRI) of thigh muscles is increasingly used to assess disease activity and damage extent in chronic myositis, but the validity of the findings is not clear. Here, the primary aim was to compare thigh MRI findings in patients having chronic myositis associated with anti-synthetase syndrome (ASS) and in matched healthy controls. METHODS: Cross-sectional analyses of thigh muscle MRI, muscular function and creatinine kinase (CK) were performed in 68 ASS patients (median disease duration 71 months) and 67 controls matched for age and gender...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28117037/validity-of-estimating-muscle-and-fat-volume-from-a-single-mri-section-in-older-adults-with-sarcopenia-and-sarcopenic-obesity
#10
Y X Yang, M S Chong, W S Lim, L Tay, S Yew, A Yeo, C H Tan
AIM: To determine if there is a correlation between the cross-sectional areas (CSAs) in a single section and the volumes of muscles and fat in the thigh of sarcopenic and sarcopenic obesity (SO) populations using magnetic resonance imaging (MRI), and to assess the correlation between thigh MRI data and patient health status, i.e., normal, obese, sarcopenia, and SO. MATERIALS AND METHODS: One hundred and ninety community-dwelling older adults were recruited and categorised into four subgroups based on Asian established criteria: normal, obese, sarcopenia, and SO...
January 20, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28109678/paclitaxel-induced-increase-in-mitochondrial-volume-mediates-dysregulation-of-intracellular-ca-2-in-putative-nociceptive-glabrous-skin-neurons-from-the-rat
#11
Eser Yilmaz, Simon C Watkins, Michael S Gold
We have recently demonstrated that in a rat model of chemotherapy-induced peripheral neuropathy (CIPN), there is a significant decrease in the duration of the depolarization-evoked Ca(2+) transient in small diameter, IB4+, and capsaicin-responsive neurons innervating the glabrous skin of the hindpaw. This change was specific to the transient duration and significantly smaller if not undetectable in neurons innervating the dorsal skin of the hindpaw or the skin of the inner thigh. Given the importance of mitochondria in intracellular Ca(2+) regulation and the findings of chemotherapy-associated increase in mitotoxicity along the sensory neuron axons, we hypothesized that CIPN is due to both increases and decreases in mitochondria function, with changes manifest in distinct subpopulations of afferents...
January 16, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28089468/obtain-a-outcome-benefits-of-tranexamic-acid-in-hip-arthroplasty-a%C3%A2-randomized-double-blinded-controlled-trial
#12
Andrew Fraval, Peter Effeney, Lena Fiddelaers, Belinda Smith, Ben Towell, Phong Tran
BACKGROUND: We examined whether the blood conserving effect of tranexamic acid (TXA) in total hip arthroplasty using the direct anterior approach, translates to an effect on functional outcomes in the perioperative period. METHODS: We conducted a single-center, randomized, double-blinded, placebo-controlled trial. One hundred one patients were randomized to receive either TXA or an equivalent volume of normal saline. The primary outcome measure was thigh swelling...
December 8, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28060999/statistical-image-domain-multi-material-decomposition-for-dual-energy-ct
#13
Yi Xue, Ruoshui Ruan, Xiuhua Hu, Yu Kuang, Jing Wang, Yong Long, Tianye Niu
PURPOSE: Dual-energy CT (DECT) enhances tissue characterization because of its basis material decomposition capability. In addition to conventional two-material decomposition from DECT measurements, multi-material decomposition (MMD) is required in many clinical applications. To solve the ill-posed problem of reconstructing multiple-material images from dual-energy measurements, additional constraints are incorporated into the formulation, including volume and mass conservation and the assumptions that at most three materials in each pixel and various material types among pixels...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28046024/chest-fat-quantification-via-ct-based-on-standardized-anatomy-space-in-adult-lung-transplant-candidates
#14
Yubing Tong, Jayaram K Udupa, Drew A Torigian, Dewey Odhner, Caiyun Wu, Gargi Pednekar, Scott Palmer, Anna Rozenshtein, Melissa A Shirk, John D Newell, Mary Porteous, Joshua M Diamond, Jason D Christie, David J Lederer
PURPOSE: Overweight and underweight conditions are considered relative contraindications to lung transplantation due to their association with excess mortality. Yet, recent work suggests that body mass index (BMI) does not accurately reflect adipose tissue mass in adults with advanced lung diseases. Alternative and more accurate measures of adiposity are needed. Chest fat estimation by routine computed tomography (CT) imaging may therefore be important for identifying high-risk lung transplant candidates...
2017: PloS One
https://www.readbyqxmd.com/read/28038376/lean-muscle-volume-of-the-thigh-has-a-stronger-relationship-with-muscle-power-than-muscle-strength-in-women-with-knee-osteoarthritis
#15
Michael J Davison, Monica R Maly, Peter J Keir, Sandani M Hapuhennedige, Amie T Kron, Jonathan D Adachi, Karen A Beattie
BACKGROUND: Thigh lean muscle and intramuscular fat have been implicated in the impairment of physical function observed in people with knee osteoarthritis. We investigated the relationships of quadriceps and hamstrings intramuscular fat fraction and lean muscle volume with muscle power and strength, controlling for neuromuscular activation, and physical performance in women with knee OA. METHODS: Women (n=20) 55years or older with symptomatic, radiographic knee osteoarthritis underwent a 3...
January 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/27999722/effect-of-different-foam-rolling-volumes-on-knee-extension-fatigue
#16
Estêvão Rios Monteiro, Victor Gonçalves Corrêa Neto
BACKGROUND: Foam rolling (FR) is a common intervention utilized for the purpose of acutely increasing range-of-motion without subsequent decreases in performance. FR is characterized as an active technique which subject performs upon themselves. Thus, it is believed that the accumulated fatigue can influence whether the task can be continued. PURPOSE: To analyze the effect of different foam rolling volumes on fatigue of the knee extensors. METHODS: Twenty-five recreationally active females (age 27...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27998663/reconstruction-with-soft-tissue-free-flaps-for-large-defects-after-the-resection-of-giant-facial-neurofibroma
#17
L Hu, Y Xi, Y Wang, L Jiannan, J Han, Y Miao, S Gokavarapu, C Zhang, L Xu
Giant facial neurofibroma leads to disfigurement and functional and neurological deficits. Surgical resection is the mainstay of treatment and poses a great challenge to the surgeon with regard to the restoration of the defects arising from tumour resection. The cases of three male and three female patients diagnosed with giant facial neurofibroma, who underwent radical resection and reconstruction with soft tissue free flaps between 2008 and 2015, were analyzed retrospectively. Clinical data including patient sex, age, preoperative embolization of the nutrient artery, volume of blood loss, type and size of flaps used for reconstruction, and complications were recorded...
December 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27987620/validation-of-the-novel-venous-drainage-index-with-stepwise-increases-in-thigh-compression-pressure-in-the-quantification-of-venous-obstruction
#18
Christopher R Lattimer, Stephen Doucet, George Geroulakos, Evi Kalodiki
BACKGROUND: Venous drainage from the leg is poorly understood, and it is difficult to quantify it hemodynamically. Attempts have been made using duplex ultrasound scanning and venous occlusion air plethysmography (APG). However, they have limited value in day-to-day clinical practice. This is because venous drainage measurements have never been validated successfully against increasing obstruction pressures. The hypothesis is that the novel gravitational venous drainage index (VDI) in milliliters/second is reduced in response to increasing venous obstruction, and the aim was to quantify this, using stepwise inflations of a thigh cuff...
January 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27958689/predictive-value-of-a-day-orthostatic-loading-test-for-the-reversibility-of-the-great-saphenous-vein-reflux-after-phlebectomy-of-all-varicous-tributaries
#19
Yurii T Tsukanov, Anton Y Tsukanov
BACKGROUND: To evaluate predictive value of a day orthostatic loading test (DOL-test) for the reversibility of the great saphenous vein (GSV) reflux after phlebectomy of all varicose tributaries (VTs). METHODS: Prospective cohort study.Patients with reflux in the GSV were included. Patients were treated by phlebectomy for all VTs of the GSV. GSV reflux was measured during a duplex ultrasound examination with DOL-test according to: 1) reflux location and donor vein; 2) reflux extent (RE) of the GSV was evaluated according to the number of zones of reflux (NZR) which included three thigh and three calf zones; 3) reflux duration (RD); 4) peak reflux velocity (PRV) in GSV reflux point of initiation; 5) the diameter of the GSV; 6) orthostatic gradient (OG) - difference between evening and morning values of the GSV diameter...
December 13, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27955950/resistive-training-and-molecular-regulators-of-vascular-metabolic-risk-in-chronic-stroke
#20
Alice S Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M Ivey
BACKGROUND: Peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC-1α) gene and Sirtuin-1 (SIRT-1) respond to physiological stimuli and regulate insulin resistance. Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. Resistive training (RT) reduces hyperinsulinemia and improves insulin action in chronic stroke...
December 9, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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