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https://www.readbyqxmd.com/read/29767469/cd109-deficiency-induces-osteopenia-with-an-osteoporosis-like-phenotype-in-vivo
#1
Shinji Mii, Akiyoshi Hoshino, Atsushi Enomoto, Yoshiki Murakumo, Masako Ito, Akira Yamaguchi, Masahide Takahashi
Osteoporosis is a global public health problem that is increasing along with an aging population. A major determinant of osteoporosis is high bone turnover, which results from osteoclast activation. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, a deficiency that leads to a psoriasis-like skin inflammation in mice. Although the expression of CD109 has been reported in mouse pre-osteoclast cells, its function in osteoclasts in vivo remains largely unknown. To investigate the physiological role of CD109 in bone metabolism, we analyzed bones from wild-type and CD109-deficient adult mice...
May 16, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29687650/effect-of-protein-supplementation-during-diet-induced-weight-loss-on-muscle-mass-and-strength-a-randomized-controlled-study
#2
Gordon I Smith, Paul K Commean, Dominic N Reeds, Samuel Klein, Bettina Mittendorfer
OBJECTIVE: High protein (particularly leucine-rich whey protein) intake is recommended to mitigate the adverse effect of weight loss on muscle mass. The effectiveness of this approach is unknown. METHODS: Seventy middle-aged (50-65 years old) postmenopausal women with obesity were randomized to (1) weight maintenance (WM), (2) weight loss and the recommended daily allowance for protein (0.8 g/kg/d) (WL group), or (3) weight loss plus whey protein supplementation (total protein: 1...
May 2018: Obesity
https://www.readbyqxmd.com/read/29675640/effects-of-combined-whole-body-electromyostimulation-and-protein-supplementation-on-local-and-overall-muscle-fat-distribution-in-older-men-with-sarcopenic-obesity-the-randomized-controlled-franconia-sarcopenic-obesity-franso-study
#3
Wolfgang Kemmler, Alexandra Grimm, Michael Bebenek, Matthias Kohl, Simon von Stengel
The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a non-intervention control group (CG: n = 34). WB-EMS was conducted 1.5 sessions of 20 min/week for 16 weeks. Whey protein supplementation aimed to ensure a daily intake of 1...
April 19, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#4
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29663025/imaging-appearance-of-well-differentiated-liposarcomas-with-myxoid-stroma
#5
Yoav Morag, Corrie Yablon, Monica Kalume Brigido, Jon Jacobson, David Lucas
OBJECTIVE: Describe the imaging appearance of well-differentiated liposarcoma with myxoid stroma (WDLMS) and correlate with histopathology. MATERIALS AND METHODS: A keyword search of the institution medical records was performed from 1 January 2000 to 30 June 2017. The histopathology slides of cases identified in this fashion were then reviewed by a pathologist. Additional cases were prospectively collected from extramural referrals and tumor boards. Diagnostic imaging studies of pathologically proven cases of WDLMS were then reviewed in consensus and correlated with pathology...
April 16, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29616175/single-lymphaticovenular-anastomosis-for-early-stage-lower-extremity-lymphedema-treated-by-the-superior-edge-of-the-knee-incision-method
#6
Yukio Seki, Akiyoshi Kajikawa, Takumi Yamamoto, Takayuki Takeuchi, Takahiro Terashima, Norimitsu Kurogi
Background: Surgical treatment of lower extremity lymphedema (LEL) remains challenging. Application of the superior-edge-of-the-knee incision method for lymphaticovenular anastomosis (LVA) is reported to have a strong therapeutic effect in patients with LEL because lymph-to-venous flow at the anastomosis is enhanced by knee joint movement during normal walking. We investigated whether a single LVA created by this method is adequate for early LEL. Methods: The study involved 10 patients with LEL characterized by stage 2 or 3 leg dermal backflow and treated by a single LVA at the thigh via the superior-edge-of-the-knee incision method...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29590721/chemerin-blood-levels-are-associated-with-mri-measured-volumes-of-abdominal-adipose-tissue-compartments-and-lifestyle-choices
#7
Tamer Salha, David Andrijević, Zvonimir Vrselja, Vatroslav Šerić, Radivoje Radić, Goran Curic
Obesity is a low-grade chronic inflammatory state, in which a cytokine chemerin with its immunometabolic modulation has an important role. We aimed to study in a healthy population relationships between serum chemerin levels, lifestyle choices and magnetic resonance imaging (MRI) assessed volumes of abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues, which have different cytokine expression profiles. Overall, 73 healthy participants undertook lifestyle questionnaire and underwent anthropometric measurements along with MRI scanning of abdominal SAT and VAT...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29570534/neuromuscular-adaptations-to-work-matched-maximal-eccentric-vs-concentric-training
#8
Sumiaki Maeo, Xiyao Shan, Shun Otsuka, Hiroaki Kanehisa, Yasuo Kawakami
It is unclear whether the superiority of eccentric over concentric training on neuromuscular improvements is due to higher torque (mechanical loading) achievable during eccentric contractions or due to resulting greater total work. PURPOSE: To examine neuromuscular adaptations following maximal eccentric versus concentric training matched for total work. METHODS: Twelve males conducted single-joint isokinetic (180°/s) maximal eccentric contractions of the knee extensors in one leg (ECC-leg) and concentric in the other (CON-leg), 6 sets/session (3-5 sets in the initial 1-3 sessions), 2 sessions/week for 10 weeks...
March 22, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29558775/-chronic-compartment-syndrome
#9
Andreas Gösele-Koppenburg
Chronic compartment syndromes are a rare, but frequently overlooked cause of pain in the locomotor system. Their aetiology is still not fully elucidated. There is an imbalance of muscle volume and space in the compartment. Thickening of the fascia and decreased elasticity lead to a pathological increase in pressure in the compartment under load. Chronic compartment syndromes are found in the foot, lower leg, thigh, forearm, hand, and even the spine. Bilateral compartment syndromes are very common (80 %). The main symptoms are pain in the compartment under physical activity...
March 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29546320/relationship-of-physical-function-to-single-muscle-fiber-contractility-in-older-adults-effects-of-resistance-training-with-and-without-caloric-restriction
#10
Zhong-Min Wang, Xiaoyan Leng, María Laura Messi, Seung J Choi, Anthony P Marsh, Barbara Nicklas, Osvaldo Delbono
Background: Previous studies support beneficial effects of both resistance exercise training (RT) and caloric restriction (CR) on skeletal muscle strength and physical performance. The goal of this study was to determine the effects of adding CR to RT on single-muscle fiber contractility responses to RT in older overweight and obese adults. Methods: We analyzed contractile properties in 1,253 single myofiber from muscle biopsies of the vastus lateralis, as well as physical performance and thigh muscle volume, in 31 older (65-80 yrs), overweight or obese (body mass index= 27-35 kg/m2) men (n=19) and women (n=12) who were randomly assigned to a standardized, progressive RT intervention with CR (RT+CR; n=15) or without CR (RT; n=16) for 5 months...
March 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29545115/pre-and-postoperative-radiotherapy-for-extremity-soft-tissue-sarcoma-evaluation-of-inter-observer-target-volume-contouring-variability-among-french-sarcoma-group-radiation-oncologists
#11
P Sargos, T Charleux, R L Haas, A Michot, C Llacer, L Moureau-Zabotto, G Vogin, C Le Péchoux, C Verry, A Ducassou, M Delannes, A Mervoyer, N Wiazzane, J Thariat, M P Sunyach, M Benchalal, J D Laredo, M Kind, P Gillon, G Kantor
PURPOSE: The purpose of this study was to evaluate, during a national workshop, the inter-observer variability in target volume delineation for primary extremity soft tissue sarcoma radiation therapy. METHODS AND MATERIALS: Six expert sarcoma radiation oncologists (members of French Sarcoma Group) received two extremity soft tissue sarcoma radiation therapy cases 1: one preoperative and one postoperative. They were distributed with instructions for contouring gross tumour volume or reconstructed gross tumour volume, clinical target volume and to propose a planning target volume...
March 12, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29489578/ablation-of-buccal-cancer-and-functionality-buccal-reconstruction-using-an-individuation-anterolateral-thigh-flap
#12
Ting Zhou, Lei Zhang, Guowen Sun, Qingang Hu
The complex area for reconstruction of the head and the neck is the buccal because of difficult anatomy of this region. This article aimed to describe our individualized design for the reconstruction of the buccal using an different categories anterolateral thigh (ALT) flap. Ninety-four patients were involved in this study. Among 94cases, the number of using the musculocutaneous ALT flap was 57, using the fasciocutaneous ALT flap was 25, and using the thin ALT flap was 12. Postoperative vessel thrombosis occurred in 8 flaps, and required operative exploration in the perioperative period, 6 flaps were complete survival after the salvages, 2 flap was failure...
February 27, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29485489/biological-response-to-time-controlled-adaptive-ventilation-depends-on-acute-respiratory-distress-syndrome-etiology
#13
Pedro Leme Silva, Fernanda Ferreira Cruz, Cynthia Dos Santos Samary, Lillian Moraes, Raquel Ferreira de Magalhães, Marcos Vinicius de S Fernandes, Rebeca Bose, Vitor B Pelegati, Hernandes F Carvalho, Vera Luiza Capelozzi, Joshua Satalin, Louis Gatto, Penny Andrews, Nader Habashi, Gary Nieman, Patricia R M Rocco
OBJECTIVES: To compare a time-controlled adaptive ventilation strategy, set in airway pressure release ventilation mode, versus a protective mechanical ventilation strategy in pulmonary and extrapulmonary acute respiratory distress syndrome with similar mechanical impairment. DESIGN: Animal study. SETTING: Laboratory investigation. SUBJECTS: Forty-two Wistar rats. INTERVENTIONS: Pulmonary acute respiratory distress syndrome and extrapulmonary acute respiratory distress syndrome were induced by instillation of Escherichia coli lipopolysaccharide intratracheally or intraperitoneally, respectively...
February 26, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29482601/efficacy-of-high-intensity-low-volume-interval-training-compared-to-continuous-aerobic-training-on-insulin-resistance-skeletal-muscle-structure-and-function-in-adults-with-metabolic-syndrome-study-protocol-for-a-randomized-controlled-clinical-trial-intraining
#14
Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón
BACKGROUND: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect...
February 27, 2018: Trials
https://www.readbyqxmd.com/read/29463385/a-comparison-of-methods-to-determine-center-of-mass-during-pregnancy
#15
Robert D Catena, Christopher P Connolly, Kendra M McGeorge, Nigel Campbell
Balance changes during pregnancy likely occur because of mass gains and mass distribution changes. However, to date there is no way of tracking balance through center of mass motion because no method is available to identify of the body center of mass throughout pregnancy. We compared methods for determining segment masses and torso center of mass location. The availability of a method for tracking these changes during pregnancy will make determining balance changes through center of mass motion an option for future pregnancy balance research...
April 11, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29461377/total-lower-lip-reconstruction-with-functional-gracilis-free-muscle-flap
#16
Mehmet Akif Cakmak, Hakan Cinal, Ensar Zafer Barin, Muhammed Sedat Sakat, Harun Karaduman, Onder Tan
Free flaps based on static slings principles cannot provide esthetic and functional outcomes at a desired level in total or close to total lip loss. Therefore, dynamic methods have become a current issue in recent years and especially the idea of functional gracilis free muscle flap has been suggested. In this study, we present a case of a successful total lower lip repair with this flap.In a 78-year-old female patient who was diagnosed with squamous cell carcinoma involving the entire lower lip, bilateral modified radical neck dissection and full-thickness total resection with 1 cm surgical margin so as to include both commissures of the tumor were performed and then a free gracilis muscle flap was transferred from the same side...
May 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29446524/impact-of-blood-flow-restricted-bodyweight-exercise-on-skeletal-muscle-adaptations
#17
J E Jakobsgaard, M Christiansen, P Sieljacks, J Wang, T Groennebaek, F de Paoli, K Vissing
This study ascertains the ability of bodyweight blood flow-restricted (BFR) exercise training to promote skeletal muscle adaptations of significance for muscle accretion and metabolism. Six healthy young individuals (three males and three females) performed six weeks of bodyweight BFR training. Each session consisted of five sets of sit-to-stand BFR exercise to volitional failure with 30-second inter-set recovery. Prior to, and at least 72 h after training, muscle biopsies were taken from m. vastus lateralis to assess changes in fibre type-specific cross-sectional area (CSA), satellite cell (SC) and myonuclei content and capillarization, as well as mitochondrial protein expression...
February 15, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29415060/precision-of-mri-based-body-composition-measurements-of-postmenopausal-women
#18
RANDOMIZED CONTROLLED TRIAL
Janne West, Thobias Romu, Sofia Thorell, Hanna Lindblom, Emilia Berin, Anna-Clara Spetz Holm, Lotta Lindh Åstrand, Anette Karlsson, Magnus Borga, Mats Hammar, Olof Dahlqvist Leinhard
OBJECTIVES: To determine precision of magnetic resonance imaging (MRI) based fat and muscle quantification in a group of postmenopausal women. Furthermore, to extend the method to individual muscles relevant to upper-body exercise. MATERIALS AND METHODS: This was a sub-study to a randomized control trial investigating effects of resistance training to decrease hot flushes in postmenopausal women. Thirty-six women were included, mean age 56 ± 6 years. Each subject was scanned twice with a 3...
2018: PloS One
https://www.readbyqxmd.com/read/29402350/evaluation-of-volume-of-intramuscular-injection-into-the-caudal-thigh-muscles-of-female-and-male-balb-c-mice-mus-musculus
#19
Alicia M Gehling, Kyle Kuszpit, Emily J Bailey, Krystal H Allen-Worthington, David P Fetterer, Pedro J Rico, Thomas M Bocan, Christian C Hofer
This study presents recommendations for intramuscular injection into the caudal thigh muscle of mice according to analysis of in vivo imaging of intramuscularly injected iohexol, a radiocontrast agent commonly used in CT imaging. An experienced laboratory animal technician using a Hamilton syringe intramuscularly injected iohexol into isoflurane-anesthetized female and male BALB/c mice. Injected volumes (25, 50, 100, and 200 μL) underwent CT scanning at 9 time points over a 3-h period. The distribution of the injectate in the muscles of the rear leg was examined over time for each volume group...
January 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29401199/effect-of-a-16-week-combined-strength-and-plyometric-training-program-followed-by-a-detraining-period-on-athletic-performance-in-pubertal-volleyball-players
#20
Abed Fathi, Raouf Hammami, Jason Moran, Rihab Borji, Sonia Sahli, Haithem Rebai
The purpose of this study was to determine the effects of 16 weeks of combined strength and plyometric training or plyometric training alone, and how a detraining program can modify adaptations in response to the training stimulus. Sixty male volleyball players (circa PHV:-1 to +1 years from PHV) were assigned to a Combined Training group (CTG) (n=20), a Plyometric Training group (PTG) (n=20) or a control group (CG) (n=20). The experimental groups (CTG and PTG) participated in training twice weekly for 16 weeks...
February 1, 2018: Journal of Strength and Conditioning Research
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