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https://www.readbyqxmd.com/read/28905498/effect-of-bimagrumab-on-thigh-muscle-volume-and-composition-in-men-with-casting-induced-atrophy
#1
Daniel S Rooks, Didier Laurent, Jens Praestgaard, Scott Rasmussen, Michael Bartlett, László B Tankó
BACKGROUND: Patients experiencing disuse atrophy report acute loss of skeletal muscle mass which subsequently leads to loss of strength and physical capacity. In such patients, especially the elderly, complete recovery remains a challenge even with improved nutrition and resistance exercise. This study aimed to explore the clinical potential of bimagrumab, a human monoclonal antibody targeting the activin type II receptor, for the recovery of skeletal muscle volume from disuse atrophy using an experimental model of lower extremity immobilization...
September 14, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28893206/efficacy-of-blood-flow-restriction-exercise-during-dialysis-for-end-stage-kidney-disease-patients-protocol-of-a-randomised-controlled-trial
#2
Matthew J Clarkson, Steve F Fraser, Paul N Bennett, Lawrence P McMahon, Catherine Brumby, Stuart A Warmington
BACKGROUND: Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a rare addition to standard care. Hypothetically, blood flow restriction exercise performed during haemodialysis can provide greater value for time spent exercising, reducing this time burden while producing similar or greater outcomes. This study will explore the efficacy of blood flow restriction exercise for enhancing strength and physical function among haemodialysis patients...
September 11, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28887332/the-cerebro-cardiovascular-response-to-periodic-squat-stand-maneuvers-in-healthy-subjects-a-time-domain-analysis
#3
Sam C Barnes, Naomi Ball, Victoria Joanna Haunton, Thompson G Robinson, Ronney B Panerai
BACKGROUND: Squat-stand maneuvers (SSMs) have been used to improve the coherence of transfer function analysis (TFA) estimates during the assessment of dynamic cerebral autoregulation (dCA). There is a need to understand the influence of peripheral changes resulting from SSMs on cerebral blood flow, which might confound estimates of dCA. METHODS: 29 healthy subjects underwent recordings at rest (5 min standing) and 15 SSMs (0.05Hz). Heart rate (3-lead ECG), end-tidal CO2 (capnography), blood pressure (Finometer), cerebral blood velocity (CBV, transcranial Doppler, MCA) and the angle of the thigh (tilt sensor) were measured continuously...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28855188/an-excitatory-reflex-from-the-superficial-peroneal-nerve-to-the-bladder-in-cats
#4
Michelle Yu, Jamie Uy, Xuewen Jiang, Xing Li, Cameron Jones, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study in α-chloralose anesthetized cats discovered an excitatory peroneal nerve-to-bladder reflex. A urethral catheter was used to infuse the bladder with saline and record bladder pressure changes. Electrical stimulation was applied to the superficial peroneal nerve to trigger a reflex bladder activity. With the bladder distended at a volume about 90% of bladder capacity, superficial peroneal nerve stimulation (PNS) at 1-3 Hz and threshold (T) intensity for inducing muscle twitching on the posterior thigh induced large amplitude (40-150 cmH2O) bladder contractions...
August 30, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28846613/method-for-estimating-three-dimensional-knee-rotations-using-two-inertial-measurement-units-validation-with-a-coordinate-measurement-machine
#5
Rachel V Vitali, Stephen M Cain, Ryan S McGinnis, Antonia M Zaferiou, Lauro V Ojeda, Steven P Davidson, Noel C Perkins
Three-dimensional rotations across the human knee serve as important markers of knee health and performance in multiple contexts including human mobility, worker safety and health, athletic performance, and warfighter performance. While knee rotations can be estimated using optical motion capture, that method is largely limited to the laboratory and small capture volumes. These limitations may be overcome by deploying wearable inertial measurement units (IMUs). The objective of this study is to present a new IMU-based method for estimating 3D knee rotations and to benchmark the accuracy of the results using an instrumented mechanical linkage...
August 27, 2017: Sensors
https://www.readbyqxmd.com/read/28846496/whole-body-imaging-of-tissue-specific-insulin-sensitivity-and-body-composition-by-using-an-integrated-pet-mr-system-a-feasibility-study
#6
Emil Johansson, Mark Lubberink, Kerstin Heurling, Jan W Eriksson, Stanko Skrtic, Håkan Ahlström, Joel Kullberg
Purpose To develop, evaluate, and demonstrate the feasibility of a whole-body protocol for simultaneous assessment of tissue-specific insulin-mediated fluorine 18 ((18)F) fluorodeoxyglucose (FDG) influx rates, tissue depots, and whole-body insulin sensitivity (referred to as the M value). Materials and Methods An integrated positron emission tomography (PET)/magnetic resonance (MR) imaging system combined with hyperinsulinemic euglycemic clamp (HEC) was used. Dynamic whole-body PET imaging was used to determine the insulin-mediated (18)F-FDG tissue influx rate (Ki) in the whole-body region by using the Patlak method...
August 25, 2017: Radiology
https://www.readbyqxmd.com/read/28841698/long-term-follow-up-of-mri-changes-in-thigh-muscles-of-patients-with-facioscapulohumeral-dystrophy-a-quantitative-study
#7
Farzad Fatehi, Emmanuelle Salort-Campana, Arnaud Le Troter, Emilie Lareau-Trudel, Mark Bydder, Alexandre Fouré, Maxime Guye, David Bendahan, Shahram Attarian
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common hereditary muscular disorders. Currently FSHD has no known effective treatment and detailed data on the natural history are lacking. Determination of the efficacy of a given therapeutic approach might be difficult in FSHD given the slow and highly variable disease progression. Magnetic resonance imaging (MRI) has been widely used to qualitatively and quantitatively evaluate in vivo the muscle alterations in various neuromuscular disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28835396/human-dorsal-root-ganglion-in-vivo-morphometry-and-perfusion-in-fabry-painful-neuropathy
#8
Tim Godel, Philipp Bäumer, Mirko Pham, Anja Köhn, Nicole Muschol, Moritz Kronlage, Jennifer Kollmer, Sabine Heiland, Martin Bendszus, Victor-Felix Mautner
OBJECTIVE: To evaluate functional and morphometric magnetic resonance neurography of the dorsal root ganglion and peripheral nerve segments in patients with Fabry painful neuropathy. METHODS: In this prospective study, the lumbosacral dorsal root ganglia and proximal peripheral nerve segments of the lower extremity were examined in 11 male patients with Fabry disease by a standardized 3T magnetic resonance neurography protocol. Volumes of L3 to S2 dorsal root ganglia, perfusion parameters of L5-S1 dorsal root ganglia and the spinal nerve L5, and the cross-sectional area of the proximal sciatic nerve were compared to healthy controls...
August 23, 2017: Neurology
https://www.readbyqxmd.com/read/28806771/effect-of-knee-alignment-on-the-quadriceps-femoris-muscularity-cross-sectional-comparison-of-trained-versus-untrained-individuals-in-both-sexes
#9
Ryoichi Ema, Taku Wakahara, Kuniaki Hirayama, Yasuo Kawakami
Knee alignment is suggested to be a factor affecting each quadriceps femoris muscle size, and knee alignment such as Q-angle differs between men and women. Also, training can induce inhomogeneous hypertrophy among the quadriceps femoris, thereby leading to different component characteristics of the muscles. If Q-angle is a major determinant of the quadriceps femoris muscularity, it is hypothesized that the sex-related difference in the quadriceps femoris muscularity, if any, is further highlighted in trained individuals, being associated with Q-angle...
2017: PloS One
https://www.readbyqxmd.com/read/28772277/factors-to-consider-when-deciding-on-the-type-of-free-flap-reconstruction-of-head-and-neck-soft-tissue-defects
#10
Mohammed Thabet Aladimi, Bo Han, Chunjie Li, Hussein Helal, Zhenjie Gao, Longjiang Li
OBJECTIVES: The aim of the study was to evaluate the functional and aesthetic outcomes on donor and recipient sites and to determine the effects of technical factors including flap thickness and vessel diameters measured by ultrasonography as well as the size of the defect and postoperative volume reduction of the flaps measured by magnetic resonance imaging (MRI). METHODS: In patients who had undergone soft tissue reconstructive surgery between March 2013 and March 2016 using 55 anterolateral thigh flaps (ALTFs), 30 radial forearm flaps (RFFs), and 18 latissimus dorsi flaps (LDFs), color Doppler ultrasonography was performed to measure the thickness of the flap at the site of the perforator...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28761699/high-intensity-flywheel-exercise-and-recovery-of-atrophy-after-90-days-bed-rest
#11
Daniel L Belavý, Hiroshi Ohshima, Jörn Rittweger, Dieter Felsenberg
AIMS: To investigate differential muscle atrophy during bed-rest, the impact of a high-intensity concentric-eccentric (flywheel) resistance exercise countermeasure and muscle recovery after bed-rest. METHODS: Twenty-five healthy male subjects underwent 90 dayshead-down tilt bed-rest. Volume of individual lower-limb muscles was measured via MRI before, twice during and four times up to 1 year after bed-rest. Subjects were either inactive (n=16) or performed flywheel exercise every third day of bed-rest (n=9)...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28752648/foetal-fractional-thigh-volume-an-early-3d-ultrasound-marker-of-neonatal-adiposity
#12
J A Roelants, M J Vermeulen, I V Koning, I A L Groenenberg, S P Willemsen, A C S Hokken-Koelega, K F M Joosten, I K M Reiss, R P M Steegers-Theunissen
BACKGROUND: The predisposition for obesity is suggested to originate in the prenatal period. Prenatal markers are needed to identify foetuses at risk for neonatal adiposity, as early marker of childhood obesity. OBJECTIVE: The aim of this study is to assess the association between foetal fractional thigh volume (TVol) and neonatal percentage fat mass from mid-gestation onward. METHODS: In this perinatal cohort study, singleton pregnancies with term born infants were included...
August 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28747264/free-flap-surgical-correction-of-facial-deformity-after-anteromedial-maxillectomy
#13
Shunji Sarukawa, Hideaki Kamochi, Tadahide Noguchi, Ataru Sunaga, Hirokazu Uda, Yoshiyuki Mori, Hiroshi Nishino, Kotaro Yoshimura
Anteromedial maxillectomy is typically performed in conjunction with low-dose radiotherapy and intraarterial chemotherapy. In doing so, the extent of surgical defects is reduced. However, nasal deviation and oral incompetence may ensue, due to cicatricial contracture of wounds, and may be distressing to these patients. Herein, we report a series of eight free perforator flap procedures (anterolateral thigh [ALT] flap, 6; thoracodorsal artery perforator [TAP] flap, 2) used to correct such deformities. The TAP flap was combined with scapular tip [ST] osseous flap in patients with added zygomatic prominence defects...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28742086/predictive-models-for-estimating-visceral-fat-the-contribution-from-anthropometric-parameters
#14
Claudia Porto Sabino Pinho, Alcides da Silva Diniz, Ilma Kruze Grande de Arruda, Ana Paula Dornelas Leão Leite, Marina de Moraes Vasconcelos Petribú, Isa Galvão Rodrigues
BACKGROUND: Excessive adipose visceral tissue (AVT) represents an independent risk factor for cardiometabolic alterations. The search continues for a highly valid marker for estimating visceral adiposity that is a simple and low cost tool able to screen individuals who are highly at risk of being viscerally obese. The aim of this study was to develop a predictive model for estimating AVT volume using anthropometric parameters. OBJECTIVE: Excessive adipose visceral tissue (AVT) represents an independent risk factor for cardiometabolic alterations...
2017: PloS One
https://www.readbyqxmd.com/read/28737564/localized-leg-volume-index-a-new-method-for-body-type-corrected-evaluation-of-localized-leg-lymphedematous-volume-change
#15
Takumi Yamamoto, Nana Yamamoto, Hidehiko Yoshimatsu, Yukio Seki, Akiyoshi Kajikawa
BACKGROUND: Volume measurement is one of the most common evaluations for lower-extremity lymphedema. However, volume comparison between different patients with different physique may be inappropriate, and it is difficult to evaluate localized limb volume change using leg volume evaluation. METHODS: Localized leg volumes (Vk, k = 1-5) and localized leg volume indices (LEVIk) at 5 points (1, thigh; 2, knee; 3, lower leg; 4, ankle; 5, foot) of 106 legs of 53 examinees with no leg edema were calculated based on physical measurements, leg circumferences and lengths, and body mass index (BMI)...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28679199/ultrasound-guided-genitofemoral-nerve-block-for-inguinal-hernia-repair-in-the-male-adult-a-randomized-controlled-pilot-study
#16
Luciano Frassanito, Bruno A Zanfini, Sara Pitoni, Paolo Germini, Miryam Del Vicario, Gaetano Draisci
BACKGROUND: Ultrasound-guided (USG) ilioinguinal/iliohypogastric nerve (II/IHN) block is a widely validated anesthetic technique for inguinal herniorrhaphy. As the spermatic cord, scrotum, and adjacent thigh receive sensory innervation from the genital branch of genitofemoral nerve (GFN), the addition of GFN block has been suggested to improve the quality of perioperative anesthesia and analgesia. The aim of this study is to compare GFN block plus II/IHN block with II/IHN block alone for intraoperative anesthesia and post-operative pain management...
July 5, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28676289/differential-characteristics-of-skeletal-muscle-in-community-dwelling-older-adults
#17
Minoru Yamada, Yosuke Kimura, Daisuke Ishiyama, Naohito Nishio, Yuki Abe, Tomohiro Kakehi, Junko Fujimoto, Tomoya Tanaka, Shunsuke Ohji, Yuhei Otobe, Shingo Koyama, Yukiko Okajima, Hidenori Arai
BACKGROUND: Sarcopenia is diagnosed on the basis of skeletal muscle mass and muscle strength/function. However, more simple and accurate measures for muscle mass and muscle strength/function should be explored. OBJECTIVE: The aim of this study was to compare the skeletal muscle characteristics at each stage of sarcopenia (normal, presarcopenia, dynapenia, and sarcopenia) via ultrasonography, multifrequency bioelectrical impedance analysis (BIA), and physical assessment batteries in community-dwelling older adults...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28664576/exercise-versus-vasodilator-stress-limb-perfusion-imaging-for-the-assessment-of-peripheral-artery-disease
#18
Brian P Davidson, J Todd Belcik, Gregory Landry, Joel Linden, Jonathan R Lindner
PURPOSE: Our aim was to determine whether pharmacologic vasodilation is an alternative to exercise stress during limb perfusion imaging for peripheral artery disease (PAD). METHODS: Quantitative contrast-enhanced ultrasound (CEU) perfusion imaging of the bilateral anterior thigh and calf was performed in nine control subjects and nine patients with moderate to severe PAD at rest and during vasodilator stress with dipyridamole. For those who were able, CEU of the calf was then performed during modest plantar flexion exercise (20 watts)...
August 2017: Echocardiography
https://www.readbyqxmd.com/read/28653345/treatment-of-sarcopenia-with-bimagrumab-results-from-a-phase-ii-randomized-controlled-proof-of-concept-study
#19
Daniel Rooks, Jens Praestgaard, Sam Hariry, Didier Laurent, Olivier Petricoul, Robert G Perry, Estelle Lach-Trifilieff, Ronenn Roubenoff
OBJECTIVES: To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations. DESIGN: A 24-week, randomized, double-blind, placebo-controlled, parallel-arm, proof-of-concept study. SETTING: Five centers in the United States. PARTICIPANTS: Community-dwelling adults (N = 40) aged 65 and older with gait speed between 0.4 and 1.0 m/s over 4 m and an appendicular skeletal muscle index of 7...
June 27, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28651860/fractional-fetal-thigh-volume-in-the-prediction-of-normal-and%C3%A2-abnormal-fetal-growth-during-the-third-trimester-of%C3%A2-pregnancy
#20
Louise E Simcox, Jenny E Myers, Tim J Cole, Edward D Johnstone
BACKGROUND: Currently, 2-dimensional ultrasound estimation of fetal size rather than fetal growth is used to define fetal growth restriction, but single estimates in late pregnancy lack sensitivity and may identify small for gestational age rather than growth restriction. Single or longitudinal measures of 3-dimensional fractional thigh volume may address this problem. OBJECTIVE: We sought to derive normal values for 3-dimensional fractional thigh volume in the third trimester, determine if fractional thigh volume is superior to 2-dimensional ultrasound biometry alone for detecting fetal growth restriction, and determine whether individualized growth assessment parameters have the potential to identify fetal growth restriction remote from term delivery...
June 23, 2017: American Journal of Obstetrics and Gynecology
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