keyword
https://read.qxmd.com/read/38392812/transcriptome-analysis-reveals-mycelial-and-fruiting-responses-to-lithium-chloride-in-coprinopsis-cinerea
#1
JOURNAL ARTICLE
Po-Lam Chan, Hoi-Shan Kwan, Yichun Xie, Ka-Hing Wong, Jinhui Chang
Lithium chloride (LiCl) has been used in signalling and molecular studies of animals, plants, and yeast. However, information on its roles in basidiomycetous fungi is still limited. In this study, we used RNA-Seq to study the effects of LiCl on Coprinopsis cinerea . LiCl enhanced mycelial growth and inhibited fruiting body formation in C. cinerea . RNA-Seq of the LiCl-treated C. cinerea resulted in a total of 14,128 genes. There were 1199 differentially expressed genes (DEGs) between the LiCl-treated samples and control samples in the mycelium stage (the first time point), and 1391 DEGs were detected when the control samples were forming hyphal knots while the treated samples were still in the mycelium (the second time point)...
February 9, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38352486/disrupted-mitochondrial-response-to-nutrients-is-a-presymptomatic-event-in-the-cortex-of-the-app-saa-knock-in-mouse-model-of-alzheimer-s-disease
#2
Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, Horst Wallrabe, Evelyn Pardo, Taylor Kim, Shagufta Rehman Alam, Song Hu, Ammasi Periasamy, George S Bloom
INTRODUCTION: Reduced brain energy metabolism, mTOR dysregulation, and extracellular amyloid-β oligomer (xcAβO) buildup characterize AD; how they collectively promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit N utrient-induced M itochondrial A ctivity (NiMA) in cultured neurons. We now report NiMA disruption in vivo . METHODS: Brain energy metabolism and oxygen consumption were recorded in APP SAA/+ mice using two-photon fluorescence lifetime imaging and multiparametric photoacoustic microscopy...
February 4, 2024: bioRxiv
https://read.qxmd.com/read/38352041/lithium-effects-in-animal-models-of-vanishing-white-matter-are-not-promising
#3
JOURNAL ARTICLE
Diede Witkamp, Ellen Oudejans, Leoni Hoogterp, Gino V Hu-A-Ng, Kathryn A Glaittli, Tamara J Stevenson, Marleen Huijsmans, Truus E M Abbink, Marjo S van der Knaap, Joshua L Bonkowsky
Vanishing white matter (VWM) is a devastating autosomal recessive leukodystrophy, resulting in neurological deterioration and premature death, and without curative treatment. Pathogenic hypomorphic variants in subunits of the eukaryotic initiation factor 2B (eIF2B) cause VWM. eIF2B is required for regulating the integrated stress response (ISR), a physiological response to cellular stress. In patients' central nervous system, reduced eIF2B activity causes deregulation of the ISR. In VWM mouse models, the extent of ISR deregulation correlates with disease severity...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38253804/marked-alteration-of-phosphoinositide-signaling-associated-molecules-in-postmortem-prefrontal-cortex-with-bipolar-disorder
#4
JOURNAL ARTICLE
Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe
AIM: The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabolic pathway of phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) and glycogen synthase kinase 3β (GSK3β), which have been assumed to be the targets of mood stabilizers such as lithium, in the postmortem brains of patients with BD...
January 22, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/37958600/transcriptional-regulation-of-the-human-5-ht1a-receptor-gene-by-lithium-role-of-deaf1-and-gsk3%C3%AE
#5
JOURNAL ARTICLE
Emerson F Harkin, Georges Nasrallah, Brice Le François, Paul R Albert
Serotonin 1A (5-HT1A) autoreceptors located on serotonin neurons inhibit their activity, and their upregulation has been implicated in depression, suicide and resistance to antidepressant treatment. Conversely, post-synaptic 5-HT1A heteroreceptors are important for antidepressant response. The transcription factor deformed epidermal autoregulatory factor 1 (Deaf1) acts as a presynaptic repressor and postsynaptic enhancer of 5-HT1A transcription, but the mechanism is unclear. Because Deaf1 interacts with and is phosphorylated by glycogen synthase kinase 3β (GSK3β)-a constitutively active protein kinase that is inhibited by the mood stabilizer lithium at therapeutic concentrations-we investigated the role of GSK3β in Deaf1 regulation of human 5-HT1A transcription...
October 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37860772/addition-of-exogenous-diacylglycerol-enhances-wnt-%C3%AE-catenin-signaling-through-stimulation-of-macropinocytosis
#6
JOURNAL ARTICLE
Yagmur Azbazdar, Nydia Tejeda-Munoz, Julia C Monka, Alex Dayrit, Grace Binder, Gunes Ozhan, Edward M De Robertis
Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by potentiation of the effects of added Wnt3a recombinant protein or the glycogen synthase kinase 3 (GSK3) inhibitor lithium chloride (LiCl, which mimics Wnt signaling) in luciferase transcriptional reporter assays. In a colorectal carcinoma cell line in which mutation of adenomatous polyposis coli (APC) causes constitutive Wnt signaling, DAG addition increased levels of nuclear β-catenin, and this increase was partially inhibited by an inhibitor of macropinocytosis...
October 20, 2023: IScience
https://read.qxmd.com/read/37844866/chir99021-causes-inactivation-of-tyrosine-hydroxylase-and-depletion-of-dopamine-in-rat-brain-striatum
#7
JOURNAL ARTICLE
Sally Hamdon, Pol Fernandez-Gonzalez, Muhammad Yusof Omar, Marta González-Sepúlveda, Jordi Ortiz, Carles Gil
CHIR99021, also known as laduviglusib or CT99021, is a Glycogen-synthase kinase 3β (GSK3β) inhibitor, which has been reported as a promising drug for cardiomyocyte regeneration or treatment of sensorial hearing loss. Since the activation of dopamine (DA) receptors regulates dopamine synthesis and they can signal through the β-arrestin pathway and GSK3β, we decided to check the effect of GSK3β inhibitors (CHIR99021, SB216763 and lithium ion) on the control of DA synthesis. Using ex vivo experiments with minces from rat brain striatum, we observed that CHIR99021, but not SB216763 or lithium, causes complete abrogation of both DA synthesis and accumulation, pointing to off-target effects of CHIR99021...
October 14, 2023: Neuropharmacology
https://read.qxmd.com/read/37754222/involvement-of-glycogen-synthase-kinase-3%C3%AE-gsk3%C3%AE-in-formation-of-phosphorylated-tau-and-death-of-retinal-ganglion-cells-of-rats-caused-by-optic-nerve-crush
#8
JOURNAL ARTICLE
Yurie Fukiyama, Takahisa Hirokawa, Shinji Takai, Teruyo Kida, Hidehiro Oku
Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is involved in death of retinal ganglion cells (RGCs) after optic nerve crush (ONC). It has been proposed that glycogen synthase kinase 3β (GSK3β) is involved in the hyperphosphorylation of tau in Alzheimer's disease. To determine the roles of GSK3β in tauopathy-related death of RGCs, lithium chloride (LiCl), a GSK3β inhibitor, was injected intravitreally just after ONC...
August 22, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37436577/cytomegalovirus-infection-induces-alzheimer-s-disease-associated-alterations-in-tau
#9
JOURNAL ARTICLE
Prapti H Mody, Kelsey N Marvin, DiAnna L Hynds, Laura K Hanson
Alzheimer's disease (AD) manifests with loss of neurons correlated with intercellular deposition of amyloid (amyloid plaques) and intracellular neurofibrillary tangles of hyperphosphorylated tau. However, targeting AD hallmarks has not as yet led to development of an effective treatment despite numerous clinical trials. A better understanding of the early stages of neurodegeneration may lead to development of more effective treatments. One underexplored area is the clinical correlation between infection with herpesviruses and increased risk of AD...
July 12, 2023: Journal of Neurovirology
https://read.qxmd.com/read/37055897/advances-in-the-therapeutic-potential-of-inhibitors-targeting-glycogen-synthase-kinase-3-in-inflammatory-diseases
#10
JOURNAL ARTICLE
Yifan Zhu, Hui Wang, Yueyue Guo, Jie Cao, Huanqiu Li
Glycogen synthase kinase-3 (GSK3) is one of the important serine/threonine protein kinases and has two isoforms, namely, GSK3α and GSK3β. GSK3 inhibits glycogen synthase activity through phosphorylation. It plays a key role in various pathophysiological processes, such as differentiation, immunity, metabolism, cell death, and cell survival. Therefore, GSK3 has evolved as an important therapeutic target for treating neurological diseases, inflammatory diseases, and cancer. In addition, GSK3 regulates inflammatory processes through NF-κB-induced expression of various cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6...
April 12, 2023: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/37028761/the-ubiquitin-ligase-herc4-suppresses-mafa-transcriptional-activity-triggered-by-gsk3%C3%AE-in-myeloma-by-atypical-k63-linked-polyubiquitination
#11
JOURNAL ARTICLE
Zubin Zhang, Mei Li, Peng Lin, Ying Ren, Yuanming He, Siyu Wang, Yujia Xu, Biyin Cao, Guanghui Wang, Michael F Moran, Xinliang Mao
MafA and c-Maf are close members of the Maf transcription factor family and indicators of poor prognosis of multiple myeloma (MM). Our previous study finds that the ubiquitin ligase HERC4 induces c-Maf degradation but stabilizes MafA, and the mechanism is elusive. In the present study we find that HERC4 interacts with MafA and mediates its K63-linked polyubiquitination at K33. Moreover, HERC4 inhibits MafA phosphorylation and its transcriptional activity triggered by glycogen synthase kinase 3β (GSK3β)...
April 5, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/36949769/effects-of-glycogen-synthase-kinase-3%C3%AE-activity-inhibition-on-cognitive-behavioral-and-hippocampal-ultrastructural-deficits-in-adulthood-associated-with-adolescent-methamphetamine-exposure
#12
JOURNAL ARTICLE
Peng Yan, Jincen Liu, Haotian Ma, Yue Feng, Jingjing Cui, Yuying Bai, Xin Huang, Yongsheng Zhu, Shuguang Wei, Jianghua Lai
OBJECTIVE: Glycogen synthase kinase-3β (GSK3β) has been implicated in the maintenance of synaptic plasticity, memory process, and psychostimulant-induced behavioral effects. Hyperactive GSK3β in the Cornu Ammonis 1 (CA1) subregion of the dorsal hippocampus (DHP) was associated with adolescent methamphetamine (METH) exposure-induced behavioral and cognitive deficits in adulthood. This study aimed to evaluate the possible therapeutic effects of GSK3β inhibition in adulthood on adolescent METH exposure-induced long-term neurobiological deficits...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36923652/editorial-the-protein-kinase-gsk3-in-neurobiological-functions-and-neuronal-disorders
#13
EDITORIAL
Florian Plattner, Shin-Ichi Hisanaga, Raymond Chuen-Chung Chang, Anna Matynia
No abstract text is available yet for this article.
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36795689/administration-of-a-single-dose-of-lithium-ameliorates-rhabdomyolysis-associated-acute-kidney-injury-in-rats
#14
JOURNAL ARTICLE
Maria Heloisa Massola Shimizu, Rildo Aparecido Volpini, Ana Carolina de Bragança, Mariana Moura Nascimento, Desiree Rita Denelle Bernardo, Antonio Carlos Seguro, Daniele Canale
Rhabdomyolysis is characterized by muscle damage and leads to acute kidney injury (AKI). Clinical and experimental studies suggest that glycogen synthase kinase 3β (GSK3β) inhibition protects against AKI basically through its critical role in tubular epithelial cell apoptosis, inflammation and fibrosis. Treatment with a single dose of lithium, an inhibitor of GSK3β, accelerated recovery of renal function in cisplatin and ischemic/reperfusion-induced AKI models. We aimed to evaluate the efficacy of a single dose of lithium in the treatment of rhabdomyolysis-induced AKI...
2023: PloS One
https://read.qxmd.com/read/36753380/lithium-induced-ciliary-lengthening-sparks-arp2-3-complex-dependent-endocytosis
#15
JOURNAL ARTICLE
Brae M Bigge, Larissa L Dougherty, Prachee Avasthi
Ciliary length is highly regulated, but can be disrupted by lithium, which causes ciliary elongation across cell types and organisms. We used the algal system Chlamydomonas reinhardtii to investigate the mechanism behind lithium-induced ciliary elongation. Protein synthesis is not required for lengthening and the target of lithium, GSK3, has substrates that can influence membrane dynamics. Further, ciliary assembly requires a supply of ciliary membrane as well protein.  Lithium-treated cilia elongate normally with Brefeldin treatment, but Dynasore treatment produced defective lengthening suggesting a source of membrane from the cell surface rather than the Golgi...
February 8, 2023: Molecular Biology of the Cell
https://read.qxmd.com/read/36701987/lithium-affects-the-circadian-clock-in-the-choroid-plexus-a-new-role-for-an-old-mechanism
#16
JOURNAL ARTICLE
Karolína Liška, Tereza Dočkal, Pavel Houdek, Martin Sládek, Vendula Lužná, Kateryna Semenovykh, Milica Drapšin, Alena Sumová
Lithium is an effective mood stabilizer, but the mechanism of its therapeutic action is not well understood. We investigated the effect of lithium on the circadian clock located in the ventricle barrier complex containing the choroid plexus (CP), a part of the glymphatic system that influences gross brain function via the production of cerebrospinal fluid. The mPer2Luc mice were injected with lithium chloride (LiCl) or vehicle, and their effects on the clock gene Nr1d1 in CP were detected by RT qPCR. CP organotypic explants were prepared to monitor bioluminescence rhythms in real time and examine the responses of the CP clock to LiCl and inhibitors of glycogen synthase kinase-3 (CHIR-99021) and protein kinase C (chelerythrine)...
March 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36526850/evaluation-of-in-vivo-lithium-chloride-effects-as-a-gsk3-%C3%AE-inhibitor-on-human-adipose-derived-stem-cells-differentiation-into-oligodendrocytes-and-re-myelination-in-an-animal-model-of-multiple-sclerosis
#17
JOURNAL ARTICLE
Sahar Ghosouri, Mitra Soleimani, Mohammad Bakhtiari, Nazem Ghasemi
BACKGROUND: The application of neuroprotective agents in combination with stem cells is considered a potential effective treatment for multiple sclerosis (MS). Therefore, the effects of lithium chloride as a neuroprotective agent and a GSK3-β inhibitor were evaluated in combination with human adipose derived stem cells on re-myelination, oligodendrocyte differentiation, and functional recovery. METHODS: After inducing a mouse model of MS and proving it by the hanging wire test, the mice were randomly assigned to five experimental groups: Cup, Sham, Li, hADSC, and Li + hADSC...
December 17, 2022: Molecular Biology Reports
https://read.qxmd.com/read/36504683/inhibition-of-glycogen-synthase-kinase-3-by-lithium-a-mechanism-in-search-of-specificity
#18
REVIEW
Dipashree Chatterjee, Jean Martin Beaulieu
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of lithium ions on mood regulation in bipolar disorder and other mental illnesses, including major depression, cyclothymia, and schizophrenia. Contribution of GSK3 is supported by evidence obtained from animal and patient derived model systems. However, the two GSK3 enzymes, GSK3α and GSK3β, have more than 100 validated substrates. They are thus central hubs for major biological functions, such as dopamine-glutamate neurotransmission, synaptic plasticity (Hebbian and homeostatic), inflammation, circadian regulation, protein synthesis, metabolism, inflammation, and mitochondrial functions...
2022: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36463453/low-dose-lithium-supplementation-influences-gsk3%C3%AE-activity-in-a-brain-region-specific-manner-in-c57bl6-male-mice
#19
JOURNAL ARTICLE
Rachel K Fenech, Sophie I Hamstra, Michael S Finch, Chantal R Ryan, Daniel M Marko, Brian D Roy, Val A Fajardo, Rebecca E K MacPherson
BACKGROUND: Lithium, a commonly used treatment for bipolar disorder, has been shown to have neuroprotective effects for other conditions including Alzheimer's disease via the inhibition of the enzyme glycogen synthase kinase-3 (GSK3). However, dose-dependent adverse effects of lithium are well-documented, highlighting the need to determine if low doses of lithium can reliably reduce GSK3 activity. OBJECTIVE: The purpose of this study was to evaluate the effects of a low-dose lithium supplementation on GSK3 activity in the brain of an early, diet-induced Alzheimer's disease model...
December 1, 2022: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/36209826/low-dose-lithium-supplementation-promotes-adipose-tissue-browning-and-sarco-endo-plasmic-reticulum-ca-2-atpase-uncoupling-in-muscle
#20
JOURNAL ARTICLE
Mia S Geromella, Chantal R Ryan, Jessica L Braun, Michael S Finch, Lucas A Maddalena, Olivia Bagshaw, Briana Hockey, Fereshteh Moradi, Rachel K Fenech, Jisook Ryoo, Daniel M Marko, Roopan Dhaliwal, Jake Sweezey-Munroe, Sophie I Hamstra, Georgina Gardner, Sebastian Silvera, Rene Vandenboom, Brian D Roy, Jeffrey A Stuart, Rebecca E K MacPherson, Val A Fajardo
Sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA) uncoupling in skeletal muscle, and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue are two primary mechanisms implicated in energy expenditure. Here, we investigated the effects of glycogen synthase kinase 3 (GSK3) inhibition via lithium chloride (LiCl) treatment on SERCA uncoupling in skeletal muscle and UCP1 expression in adipose. C2C12 and 3T3-L1 cells treated with LiCl had increased SERCA uncoupling and UCP1 protein levels, respectively, ultimately raising cellular respiration; however, this was only observed when LiCl treatment occurred throughout differentiation...
October 6, 2022: Journal of Biological Chemistry
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