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Lithium disease

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https://www.readbyqxmd.com/read/29768193/gsk3%C3%AE-regulates-brain-energy-metabolism
#1
Stephen A Martin, Dylan C Souder, Karl N Miller, Josef P Clark, Abdul Kader Sagar, Kevin W Eliceiri, Luigi Puglielli, T Mark Beasley, Rozalyn M Anderson
GSK3β is a serine threonine kinase implicated in the progression of Alzheimer's disease. Although the role of GSK3β in growth and pathology has been extensively studied, little is known about the metabolic consequences of GSK3β manipulation, particularly in the brain. Here, we show that GSK3β regulates mitochondrial energy metabolism in human H4 neuroglioma cells and rat PC12-derived neuronal cells and that inhibition of GSK3β in mice in vivo alters metabolism in the hippocampus in a region-specific manner...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29749462/immunotherapy-by-targeting-of-vgkc-complex-for-seizure-control-and-prevention-of-cognitive-impairment-in-a-mouse-model-of-epilepsy
#2
Zhiliang Fan, Xiaojuan Feng, Zhigang Fan, Xingyuan Zhu, Shaohua Yin
Epilepsy is a type of refractory neurologic disorder mental disease, which is associated with cognitive impairments and memory dysfunction. However, the potential mechanisms of epilepsy are not well understood. Previous evidence has identified the voltage gated potassium channel complex (VGKC) as a target in various cohorts of patients with epilepsy. In the present study, the efficacy of an antibody against VGKC (anti‑VGKC) for the treatment of epilepsy in mice was investigated. A mouse model of lithium‑pilocarpine temporal lobe epilepsy was established and anti‑VGKC treatment was administered for 30 days...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748111/dat-spect-imaging-in-cases-of-drug-induced-parkinsonism-in-a-specialty-movement-disorders-practice
#3
Jacob Yomtoob, Kimberly Koloms, Danny Bega
OBJECTIVE: Compare clinical characteristics and outcomes in cases where DAT-SPECT imaging is used to distinguish Parkinson's disease from Drug-Induced Parkinsonsim. BACKGROUND: Clinical uncertainty in diagnosing Parkinson's disease is common when patients are on dopamine-blocking medications. DAT-SPECT imaging can improve diagnostic certainty but little data are available on clinical characteristics and outcomes associated with normal and abnormal scan results. METHODS: Retrospective chart review of patients seen at a movement disorders center between 2011 and 2017 where DAT-SPECT was ordered to distinguish Parkinson's disease from Drug-induced Parkinsonism...
May 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29737895/treatment-of-seborrheic-dermatitis-a-comprehensive-review
#4
Luis J Borda, Marina Perper, Jonette E Keri
Seborrheic Dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating associated symptoms, such as pruritus; and maintaining remission with long-term therapy...
May 8, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29722029/a-regulatory-loop-connecting-wnt-signaling-and-telomere-capping-possible-therapeutic-implications-for-dyskeratosis-congenita
#5
REVIEW
Rafael Jesus Fernandez, F Brad Johnson
The consequences of telomere dysfunction are most apparent in rare inherited syndromes caused by genetic deficiencies in factors that normally maintain telomeres. The principal disease is known as dyskeratosis congenita (DC), but other syndromes with similar underlying genetic defects share some clinical aspects with this disease. Currently, there are no curative therapies for these diseases of telomere dysfunction. Here, we review recent findings demonstrating that dysfunctional (i.e., uncapped) telomeres can downregulate the WNT pathway, and that restoration of WNT signaling helps to recap telomeres by increasing expression of shelterins, proteins that naturally bind and protect telomeres...
April 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29713199/severe-mental-illness-and-chronic-kidney-disease-a-cross-sectional-study-in-the-united-kingdom
#6
Masao Iwagami, Kathryn E Mansfield, Joseph F Hayes, Kate Walters, David Pj Osborn, Liam Smeeth, Dorothea Nitsch, Laurie A Tomlinson
Objective: We investigated the burden of chronic kidney disease (CKD) among patients with severe mental illness (SMI). Methods: We identified patients with SMI among all those aged 25-74 registered in the UK Clinical Practice Research Datalink as on March 31, 2014. We compared the prevalence of CKD (two measurements of estimated glomerular filtration rate <60 mL/min/1.73 m2 for ≥3 months) and renal replacement therapy between patients with and without SMI. For patients with and without a history of lithium prescription separately, we used logistic regression to examine the association between SMI and CKD, adjusting for demographics, lifestyle characteristics, and known CKD risk factors...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29644863/reversible-cation-selective-attachment-and-self-assembly-of-human-tau-on-supported-brain-lipid-membranes
#7
Stefania A Mari, Susanne Wegmann, Katharina Tepper, Bradley Hyman, Eva-Maria Mandelkow, Eckhard Mandelkow, Daniel J Müller
Misfolding and aggregation of the neuronal, microtubule associated protein tau is involved in the pathogenesis of Alzheimer's disease and tauopathies. It has been proposed that neuronal membranes could play a role in tau release, internalization and aggregation, and that tau aggregates could exert toxicity via membrane permeabilization. Whether and how tau interacts with lipid membranes remains a matter of discussion. Here, we characterize the interaction of full-length human tau (htau40) with supported lipid membranes (SLMs) made from brain total lipid extract by time-lapse high-resolution atomic force microscopy (AFM)...
April 12, 2018: Nano Letters
https://www.readbyqxmd.com/read/29643002/3d-printing-of-a-lithium-calcium-silicate-crystal-bioscaffold-with-dual-bioactivities-for-osteochondral-interface-reconstruction
#8
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29614649/chronic-lithium-treatment-increases-telomere-length-in-parietal-cortex-and-hippocampus-of-triple-transgenic-alzheimer-s-disease-mice
#9
Giancarlo de Mattos Cardillo, Vanessa de Jesus Rodrigues De-Paula, Eliza Hiromi Ikenaga, Luciana Rodrigues Costa, Sergio Catanozi, Evelin Lisete Schaeffer, Wagner Farid Gattaz, Daniel Shikanai Kerr, Orestes Vicente Forlenza
Telomere length (TL) is a biomarker of cell aging, and its shortening has been linked to several age-related diseases. In Alzheimer's disease (AD), telomere shortening has been associated with neuroinflammation and oxidative stress. The majority of studies on TL in AD were based on leucocyte DNA, with little information about its status in the central nervous system. In addition to other neuroprotective effects, lithium has been implicated in the maintenance of TL. The present study aims to determine the effect of chronic lithium treatment on TL in different regions of the mouse brain, using a triple-transgenic mouse model (3xTg-AD)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#10
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29606078/risk-factors-for-utilization-of-acute-care-services-for-lithium-toxicity
#11
Lauren J Heath, Sarah J Billups, Kerri M Gaughan, Kristen N Gardner, Daniel Dugan, Sheila R Botts
OBJECTIVE: This study evaluated risk factors for utilization of acute care services (ACS) (hospitalization or emergency department or urgent care visit) for lithium toxicity and the prevalence of lithium toxicity in a large, ambulatory population. METHODS: A nested case-control study compared lithium users with ACS utilization for lithium toxicity (case group) to lithium users without toxicity (control group) by using data from Kaiser Permanente Colorado for patients with at least one lithium prescription purchase...
April 2, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29603378/wireless-implantable-coil-with-parametric-amplification-for-in-vivo-electron-paramagnetic-resonance-oximetric-applications
#12
Ayano Enomoto, Chunqi Qian, Nallathamby Devasahayam, Shun Kishimoto, Nobu Oshima, Burchelle Blackman, Rolf E Swenson, James B Mitchell, Alan P Koretsky, Murali C Krishna
PURPOSE: To develop an implantable wireless coil with parametric amplification capabilities for time-domain electron paramagnetic resonance (EPR) spectroscopy operating at 300 MHz. METHODS: The wireless coil and lithium phthalocyanine (LiPc), a solid paramagnetic probe, were each embedded individually in a biocompatible polymer polydimethoxysiloxane (PDMS). EPR signals from the LiPc embedded in PDMS (LiPc/PDMS) were generated by a transmit-receive surface coil tuned to 300 MHz...
March 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29590494/endocrinopathies-and-renal-outcomes-in-lithium-therapy-impact-of-lithium-toxicity
#13
R Dineen, D Bogdanet, D Thompson, C J Thompson, L A Behan, A P McKay, G Boran, C Wall, J Gibney, V O'Keane, M Sherlock
Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects. Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Study design: A retrospective analysis was performed of the prevalence of lithium toxicity and renal, thyroid and parathyroid dysfunction in our study population...
December 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29554960/evaluation-of-a-novel-quantitative-canine-species-specific-point-of-care-assay-for-c-reactive-protein
#14
Sarah Hindenberg, Melanie Keßler, Sabine Zielinsky, Judith Langenstein, Andreas Moritz, Natali Bauer
BACKGROUND: Species-specific point-of-care tests (POCT) permit a rapid analysis of canine C-reactive protein (CRP), enabling veterinarians to include CRP in clinical decisions. Aim of the study was to evaluate a novel POCT for canine CRP (Point Strip™ Canine CRP Assay) run on a small in-house-analyzer (Point Reader™ V) using lithium heparin plasma and to compare assay performance to an already established canine CRP assay (Gentian Canine CRP Immunoassay) run on two different bench top analyzers serving as reference methods (ABX Pentra 400, AU 5800)...
March 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29549796/post-treatment-with-the-glp-1-analogue-liraglutide-alleviate-chronic-inflammation-and-mitochondrial-stress-induced-by-status-epilepticus
#15
Rui-Fang Wang, Guo-Fang Xue, Christian Hölscher, Miao-Jing Tian, Peng Feng, Ji-Ying Zheng, Dong-Fang Li
Glucagon-like peptide-1(GLP-1) is a growth factor that has neuroprotective and anti-inflammatory properties. The protease resistant GLP-1 analogue liraglutide has been shown to be neuroprotective in previous studies in animal models of Alzheimer's disease or Parkinson's disease. Status epilepticus (SE) is a complex disorder, involving many underlying pathological processes, including excitotoxic and chronic inflammatory events. The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model...
March 9, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29549438/pre-clinical-evaluation-of-oxychip-for-long-term-epr-oximetry
#16
Huagang Hou, Nadeem Khan, Sangeeta Gohain, M Lakshmi Kuppusamy, Periannan Kuppusamy
Tissue oxygenation is a critical parameter in various pathophysiological situations including cardiovascular disease and cancer. Hypoxia can significantly influence the prognosis of solid malignancies and the efficacy of their treatment by radiation or chemotherapy. Electron paramagnetic resonance (EPR) oximetry is a reliable method for repeatedly assessing and monitoring oxygen levels in tissues. Lithium octa-n-butoxynaphthalocyanine (LiNc-BuO) has been developed as a probe for biological EPR oximetry, especially for clinical use...
March 16, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29545118/cognitive-benefits-of-lithium-chloride-in-app-ps1-mice-are-associated-with-enhanced-brain-clearance-of-%C3%AE-amyloid
#17
Yijun Pan, Jennifer L Short, Stephanie A Newman, Kwok H C Choy, Durgesh Tiwari, Christopher Yap, Danielle Senyschyn, William A Banks, Joseph A Nicolazzo
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer's disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid (Aβ) levels, and the brain clearance of Aβ is reduced in AD. Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Aβ. The brain clearance of intracerebroventricularly (icv) administered125 I-Aβ42 was assessed in male Swiss outbred mice administered daily oral NaCl or LiCl (300 mg/kg for 21 days)...
March 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29531810/lithium-induces-mesenchymal-epithelial-differentiation-during-human-kidney-development-by-activation-of-the-wnt-signalling-system
#18
Karen L Price, Maria Kolatsi-Joannou, Chiara Mari, David A Long, Paul J D Winyard
Kidney function is directly linked to the number of nephrons which are generated until 32-36 weeks gestation in humans. Failure to make nephrons during development leads to congenital renal malformations, whilst nephron loss in adulthood occurs in progressive renal disease. Therefore, an understanding of the molecular processes which underlie human nephron development may help design new treatments for renal disease. Mesenchyme to epithelial transition (MET) is critical for forming nephrons, and molecular pathways which control rodent MET have been identified...
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29526990/false-positive-tsh-receptor-antibody-a-pitfall-of-third-generation-tsh-receptor-antibody-measurements-in-neonates
#19
Michiko Wada, Makoto Kita, Kaoru Kawasaki, Toru Kusakabe, Tetsuya Tagami, Noriko Satoh-Asahara, Akira Shimatsu, Koshi Hashimoto
Maternal Graves' disease (GD) during pregnancy may influence thyroid function in fetuses. Neonates born to mothers with high serum TSH receptor antibody (TRAb) levels have been reported to develop 'neonatal GD'. Therefore, evaluations of serum thyroid hormone and TRAb levels in neonates upon birth are crucial for a prompt diagnosis. At delivery, we measured TRAb with third-generation TRAb test using an M22 human monoclonal antibody in neonates by collecting umbilical cord blood in a blood collection tube with lithium-heparin, which provides a whole blood/plasma sample...
March 10, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29522578/-chronic-kidney-disease-and-renal-failure-due-to-lithium-treatment
#20
Georgina P Ossani, Diego J Martino, Jorge E Toblli
Lithium has been approved for the treatment of bipolar disorder since the 1970s and even today it is considered a first-line drug for the treatment of this disease. As bipolar disorder often begins between 15-35 years of age and requires long-term treatment, the assessment of the adverse effects of the drugs used is critical. Recently, there has been renewed interest on the risk of chronic kidney disease and kidney failure induced by lithium, with findings suggesting that both complications could be more frequent than previously considered...
September 2017: Vertex: Revista Argentina de Psiquiatriá
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