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Lithium disease

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https://www.readbyqxmd.com/read/29352395/association-between-crp-genetic-diversity-and-bipolar-disorder-comorbid-complications
#1
Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer, Ryad Tamouza
BACKGROUND: Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute phase response molecule, C-reactive protein (CRP). While the genetic diversity of CRP was amply studied in various pathological settings, little is known in BD. METHODS: 568 BD patients along with 163 healthy controls (HC) were genotyped for the following single-nucleotide polymorphisms (SNPs) on the CRP gene: intron rs1417938 (+ 29) T/A, 3'-UTR rs1130864 (+ 1444) G/A, and downstream rs1205 (+ 1846) (C/T)...
January 20, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29346806/lithium-and-renal-impairment-a-review-on-a-still-hot-topic
#2
René Ernst Nielsen, Lars Vedel Kessing, Willem A Nolen, Rasmus W Licht
INTRODUCTION: Lithium is established as an effective treatment of mania, of depression in bipolar and unipolar disorder, and in maintenance treatment of these disorders. However, due to the necessity of monitoring and concerns about irreversible adverse effects, in particular renal impairment, after long-term use, lithium might be underutilized. METHODS: This study reviewed 6 large observational studies addressing the risk of impaired renal function associated with lithium treatment and methodological issues impacting interpretation of results...
January 18, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29260296/lithium-associated-hypercalcemia-pathophysiology-prevalence-management
#3
Adrian D Meehan, Ruzan Udumyan, Mathias Kardell, Mikael Landén, Johannes Järhult, Göran Wallin
BACKGROUND: Lithium-associated hypercalcemia (LAH) is an ill-defined endocrinopathy. The aim of the present study was to determine the prevalence of hypercalcemia in a cohort of bipolar patients (BP) with and without concomitant lithium treatment and to study surgical outcomes for lithium-associated hyperparathyroidism. METHODS: Retrospective data, including laboratory results, surgical outcomes and medications, were collected from 313 BP treated with lithium from two psychiatric outpatient units in central Sweden...
December 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29227034/the-clinical-course-of-late-life-bipolar-disorder-looking-back-and-forward
#4
Annemiek Dols, Nicole Korten, Hannie Comijs, Sigfried Schouws, Moniek van Dijk, Ursula Klumpers, Aartjan Beekman, Ralph Kupka, Max Stek
OBJECTIVES: Little is known about the course of late-life bipolar disorder (LLBD). First, we studied patients with LLBD retrospectively with regard to age at first mood episode, onset polarity, predominant polarity and episode density and its associations with other clinical variables. Next, we examined prospectively the clinical course and its associated factors. METHODS: Data were used from a dynamic cohort (Dutch Older Bipolars [DOBi]) including 101 patients with LLBD (mean age of 68...
December 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29212563/clinically-relevant-and-simple-immune-system-measure-is-related-to-symptom-burden-in-bipolar-disorder
#5
Ole Köhler-Forsberg, Louisa Sylvia, Thilo Deckersbach, Michael Joshua Ostacher, Melvin McInnis, Dan Iosifescu, Charles Bowden, Susan McElroy, Joseph Calabrese, Michael Thase, Richard Charles Shelton, Mauricio Tohen, James Kocsis, Edward Friedman, Terence Ketter, Andrew Alan Nierenberg
OBJECTIVE: Immunological theories, particularly the sickness syndrome theory, may explain psychopathology in mood disorders. However, no clinical trials have investigated the association between overall immune system markers with a wide range of specific symptoms including potential gender differences. METHODS: We included two similar clinical trials, the lithium treatment moderate-dose use study and clinical and health outcomes initiatives in comparative effectiveness for bipolar disorder study, enrolling 765 participants with bipolar disorder...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29200560/a-cross-sectional-study-to-estimate-cardiovascular-risk-factors-in-patients-with-bipolar-disorder
#6
Swetha Reddy Damegunta, Prasad Rao Gundugurti
Background: There is increasing recognition of cardiovascular mortality and comorbidity in bipolar disorder (BD) in the recent times. Framingham 10 years risk of coronary heart disease (CHD) has been a widely accepted as a reliable estimate of cardiovascular risk in the general population. A few studies have estimated the relative risk of developing CHD in BDs, in India. We attempt to present a cross-sectional data from a prospective study to estimate the 10 years cardiovascular risk in BD population...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29179176/neurons-erythrocytes-and-beyond-the-diverse-functions-of-chorein
#7
Florian Lang, Lisann Pelzl, Ludger Schöls, Andreas Hermann, Michael Föller, Tilman E Schäffer, Christos Stournaras
Chorea-acanthocytosis (ChAc), a neurodegenerative disease, results from loss-of-function-mutations of the chorein-encoding gene VPS13A. Affected patients suffer from a progressive movement disorder including chorea, parkinsonism, dystonia, tongue protrusion, dysarthria, dysphagia, tongue and lip biting, gait impairment, progressive distal muscle wasting, weakness, epileptic seizures, cognitive impairment, and behavioral changes. Those pathologies may be paralleled by erythrocyte acanthocytosis. Chorein supports activation of phosphoinositide-3-kinase (PI3K)-p85-subunit with subsequent up-regulation of ras-related C3 botulinum toxin substrate 1 (Rac1) activity, p21 protein-activated kinase 1 (PAK1) phosphorylation, and activation of several tyrosine kinases...
November 28, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29154082/are-preoperative-sestamibi-scans-useful-for-identifying-ectopic-parathyroid-glands-in-patients-with-expected-multigland-parathyroid-disease
#8
Farah Karipineni, Zeyad Sahli, Helina Somervell, Aarti Mathur, Jason D Prescott, Ralph P Tufano, Martha A Zeiger
BACKGROUND: The role of preoperative localization studies in patients with hyperparathyroidism and expected multigland disease remains poorly defined. Our study investigates the usefulness of obtaining preoperative sestamibi scans and ultrasonography of the neck in identifying ectopic glands in this group of patients. METHODS: Under Institutional Review Board approval, we performed a retrospective review of patients who underwent operation for secondary hyperparathyroidism, tertiary hyperparathyroidism, lithium-induced hyperparathyroidism, and multiple endocrine neoplasia syndrome at a tertiary institution between 2004 and 2015...
January 2018: Surgery
https://www.readbyqxmd.com/read/29137395/lithium-chloride-inhibits-titanium-particle-induced-osteoclastogenesis-by-inhibiting-the-nf-%C3%AE%C2%BAb-pathway
#9
Xuanyang Hu, Zhirong Wang, Jiawei Shi, Xiaobin Guo, Liangliang Wang, Zichuan Ping, Yunxia Tao, Huilin Yang, Jun Zhou, Yaozeng Xu, Dechun Geng
Osteoclast over-activation and inflammation responses promote peri-implant osteolysis (PIO), which is the leading cause of aseptic artificial joint loosening. We examined the effect of lithium chloride (LiCl) on wear debris-induced osteoclastogenesis and inflammation. Fifty-Six C57BL/6J male mice were randomly distributed into four groups: sham control (sham, treated with phosphate buffered saline [PBS]), vehicle (treated with titanium/PBS), low-LiCl (L-LiCl, titanium: 50 mg/kg LiCl) and high-LiCl (H-LiCl, titanium: 200 mg/kg LiCl)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29127487/towards-a-unified-understanding-of-lithium-action-in-basic-biology-and-its-significance-for-applied-biology
#10
REVIEW
Eric Jakobsson, Orlando Argüello-Miranda, See-Wing Chiu, Zeeshan Fazal, James Kruczek, Santiago Nunez-Corrales, Sagar Pandit, Laura Pritchet
Lithium has literally been everywhere forever, since it is one of the three elements created in the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from place to place, and has varied widely in specific regions over evolutionary and geologic time. The biological effects of lithium are many and varied. Based on experiments in which animals are deprived of lithium, lithium is an essential nutrient. At the other extreme, at lithium ingestion sufficient to raise blood concentration significantly over 1 mM/, lithium is acutely toxic...
December 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29120844/prevalence-and-clinical-demographic-correlates-of-hyperhomocysteinemia-in-inpatients-with-bipolar-disorder-in-a-han-chinese-population
#11
Shuang-Jiang Zhou, Li-Gang Zhang, Hong-Mei Chen, Ju-Yan Li, Ran Li, Xi-Mei Zhang, Ning Wang, Jair C Soares, Ryan M Cassidy, Yingjun Zheng, Yuping Ning, Shao-Li Wang, Jing-Xu Chen, Xiang-Yang Zhang
Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent in patients with bipolar disorder (BD), placing them at greater risk of cardiovascular disease and possibly serving as a disease biomarker. However, the correlation of HHcy with demographic or clinical parameters is not well known. In this study, we examined the prevalence of HHcy and its association with these parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) levels were determined in 198 BD inpatients and 84 healthy controls...
August 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29111419/diagnosis-of-multiple-system-atrophy
#12
REVIEW
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease. Patients presenting with the cerebellar phenotype of MSA can mimic other adult-onset ataxias due to alcohol, chemotherapeutic agents, lead, lithium, and toluene, or vitamin E deficiency, as well as paraneoplastic, autoimmune, or genetic ataxias...
October 23, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29103043/examining-the-relationship-between-trace-lithium-in-drinking-water-and-the-rising-rates-of-age-adjusted-alzheimer-s-disease-mortality-in-texas
#13
Val Andrew Fajardo, Val Andrei Fajardo, Paul J LeBlanc, Rebecca E K MacPherson
BACKGROUND: Alzheimer's disease (AD) mortality rates have steadily increased over time. Lithium, the current gold standard treatment for bipolar disorder, can exert neuroprotective effects against AD. OBJECTIVE: We examined the relationship between trace levels of lithium in drinking water and changes in AD mortality across several Texas counties. METHODS: 6,180 water samples from public wells since 2007 were obtained and averaged for 234 of 254 Texas counties...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29102713/the-anticonvulsant-activity-and-cerebral-protection-of-chronic-lithium-chloride-via-nmda-receptor-nitric-oxide-and-phospho-erk
#14
Razieh Mohammad Jafari, Mohammad Hossein Ghahremani, Nastaran Rahimi, Amir Shadboorestan, Amir Rashidian, Jamileh Esmaeili, Shahram Ejtemaei Mehr, Ahmad Reza Dehpour
The underlying mechanisms for the neuroprotective effects of lithium chloride in neurodegenerative diseases such as seizures remain unknown. In present study the downstream signaling pathway of phospho-ERK/NMDA receptors/nitric oxide has been studied. For this purpose, acute and chronic effect of lithium in seizure animal model and the interaction of NMDA receptor antagonist (MK-801) and neuronal nitric oxide synthase (nNOS) inhibitor (7-NI) with these neuroprotection has been studied. Acute lithium administration showed pro-convulsive properties in pentylenetetrazole (PTZ)-induced seizure model while chronic treatment increased the seizure threshold significantly...
November 2, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29090066/lithium-chloride-can-induce-differentiation-of-human-immortalized-renvm-cells-into-dopaminergic-neurons
#15
Mitra Soleimani, Nazem Ghasemi
BACKGROUND: Stem cell-based therapy is a novel strategy for the treatment of neurodegenerative diseases. The transplantation of fully differentiated cells instead of stem cells in order to decrease serious adverse complications of stem cell therapy is a new idea. In this study, the effect of lithium chloride on dopaminergic differentiation of human immortalized RenVm cells was investigated in order to access a population of fully differentiated cells for transplantation in Parkinson disease...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29080472/the-expression-of-g-protein-coupled-receptor-kinase-5-and-its-interaction-with-dendritic-marker-microtubule-associated-protein-2-after-status-epilepticus
#16
Xiangchang Zeng, Siyu Chen, Qing Gao, Wenjing Zong, Dejian Jiang, Guirong Zeng, Luping Zhou, Lulu Chen, Wei Luo, Jian Xiao, Bo Xiao, Dongsheng Ouyang, Kai Hu
OBJECTIVE: Acute seizures induced dendritic formation and synaptogenesis promotes aberrant circuitry development and further aggravates underlying conditions towards chronic epilepsy. The G protein-coupled receptor kinase-5 (GRK5) served as a key modulator in neurogenesis and the establishment of functional neuronal circuitry. This included dendritic development, as its dysfunction could cause different central nervous system disorders, including Alzheimer's disease. However, the involvement of GRK5 in the progression of epilepsy remains unclear...
October 13, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29069113/renal-concerns-relative-to-the-use-of-lithium-in-geriatric-bipolar-disorder-patients
#17
Jakub Szpunar, Hitoshi Maeshima, George T Grossberg
BACKGROUND: Lithium is a first-line treatment for bipolar disorder in geriatric patients; however, it has long been associated with potentially significant renal consequences, including chronic kidney disease (CKD). METHODS: We reviewed the available evidence to characterize the effects of lithium on renal function, provide a consensus on periodic monitoring, and propose criteria for transitioning an older patient with bipolar disorder and renal issues to an alternate medication...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29055468/evaluation-of-lithium-serum-level-in-multiple-sclerosis-patients-a-neuroprotective-element
#18
Atieh Karimi, Kobra Bahrampour, Mohammad Amin Momeni Moghaddam, Gholamreza Asadikaram, Ghasem Ebrahimi, Masoud Torkzadeh-Mahani, Mojdeh Esmaeili Tarzi, Mohammad Hadi Nematollahi
INTRODUCTION: It has been claimed that continuous and high production of nitric oxide (NO) and its metabolites may be involved in the pathogenesis of several neurological disorders such as multiple sclerosis. A number of studies have demonstrated that lithium regulates NO levels in disorders of the central nervous system. The aim of this study was to investigate whether NO as a marker of disease activity is correlated with lithium deficiency in relapsing remitting multiple sclerosis (RR-MS)...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29049864/continuation-of-lithium-after-a-diagnosis-of-chronic-kidney-disease
#19
L V Kessing, B Feldt-Rasmussen, P K Andersen, T A Gerds, R W Licht
OBJECTIVE: To investigate whether continued lithium or anticonvulsant treatment after a first diagnosis of chronic kidney disease (CKD) was associated with progression to irreversible end-stage kidney disease. METHODS: Nationwide cohort study including all individuals in Denmark in a period from 1995 to 2012 with a diagnosis of CKD and (i) a history of lithium treatment (N = 754, among whom 238 patients had a diagnosis of bipolar disorder) or (ii) a history of anticonvulsant treatment (N = 5...
December 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29049420/production-of-proinflammatory-mediators-in-activated-microglia-is-synergistically-regulated-by-notch-1-glycogen-synthase-kinase-gsk-3%C3%AE-and-nf-%C3%AE%C2%BAb-p65-signalling
#20
Qiong Cao, Aparna Karthikeyan, S Thameem Dheen, Charanjit Kaur, Eng-Ang Ling
Microglia activation and associated inflammatory response are involved in the pathogenesis of different neurodegenerative diseases. We have reported that Notch-1 and NF-κB/p65 signalling pathways operate in synergy in regulating the production of proinflammatory mediators in activated microglia. In the latter, there is also evidence by others that glycogen synthase kinase 3β (GSK-3β) mediates the release of proinflammatory cytokines but the interrelationships between the three signalling pathways have not been fully clarified...
2017: PloS One
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