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Hani M Khojah, Sameh Ahmed, Mahran S Abdel-Rahman, Khaled M Alkhalil, Al-Badr Hamza
The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Different biochemical and clinical markers for disease activity were measured and correlated with serum levels of vitamin K homologs. There were no significant differences between RA patients and healthy subjects in demographic data...
October 8, 2016: Journal of Bone and Mineral Metabolism
Zheng-Fei Yan, Pei Lin, Yu-Shuai Wang, Wei Gao, Chang-Tian Li, Moo-Chang Kook, Tae-Hoo Yi
A Gram-negative, aerobic, non-motile, long rods with no flagellum strain, designated THG-YS3.2.1T, was isolated from rhizosphere soil of mugunghwa, collected from Kyung Hee University, Yongin, South Korea. Growth occurred at 10-40 oC (optimum 28 oC), at pH 6.0-8.0 (optimum 7.0) and at 0-1.0% NaCl (optimum 1.0%). The predominant menaquinone was menaquinone-7 (MK-7). The major cellular fatty acids were anteiso-C12:0, iso-C14:0, iso-C15:0, anteiso-C15:0, iso-C15:1 G, anteiso-C15:1 A, C15:0 2OH, C16:0, iso-C16:0, C16:0 3OH, iso-C16:0 3OH, iso-C16:1 G, C17:0 2OH, iso-C17:0 3OH, C17:1 ω6c, C18:3 ω6c (6,9,12), C18:0, summed feature 3 (C16:1 ω7c and/or iso-C15:0 2OH)...
September 13, 2016: International Journal of Systematic and Evolutionary Microbiology
Sofie Hertz Ronn, Torben Harsløf, Steen Bønløkke Pedersen, Bente Langdahl
OBJECTIVE: Clinical studies suggest that vitamin K2 protects against bone loss and fractures, however, the effect on bone quality has never been investigated. We investigated the effect of vitamin MK-7 on undercarboxylated osteocalcin (ucOC), bone mass and quality. DESIGN: We conducted a randomized, placebo-controlled, double-blinded clinical trial. METHODS: We investigated the effect of MK-7 375 µg for 12 months on bone mineral density (BMD) measured by dual x-ray absorptiometry (DXA), bone microarchitecture measured by high resolution peripheral quantitative computed tomography (HRpQCT) and biochemical bone turnover markers in 148 postmenopausal women with osteopenia...
September 13, 2016: European Journal of Endocrinology
Zhiyong Wang, Yuanqing Tan, Ding Xu, Gejiao Wang, Jihong Yuan, Shixue Zheng
A Gram-staining-negative, light pink, non-motile, rod-shaped, aerobic bacterium, designated strain XNV015T, was isolated from a vanadium mine soil. Phylogenetic analyses based on 16S rRNA gene sequences indicated that it belongs to the genus Pedobacter and was closely related to Pedobacter suwonensis DSM18130T (96.93% sequence similarity), 'Pedobacter jeongeungensis KACC 15514T' (96.88 %), Pedobacter alluvionis NWER-II11T (96.66 %), Pedobacter terrae DS-57T (96.54 %), Pedobacter kyungheensis KACC 16221T (96...
September 5, 2016: International Journal of Systematic and Evolutionary Microbiology
Young Joon Oh, Hae-Won Lee, Seul Ki Lim, Min-Sung Kwon, Jieun Lee, Ja-Young Jang, Hae Woong Park, Young-Do Nam, Myung-Ji Seo, Hak-Jong Choi
A novel halophilic bacterium, strain K7(T), was isolated from kimchi, a traditional Korean fermented food. The strain is Gram-positive, motile, and produces terminal endospores. The isolate is facultative aerobic and grows at salinities of 0.0-25.0% (w/v) NaCl (optimum 10-15% NaCl), pH 5.5-8.5 (optimum pH 7.0-7.5), and 15-42°C (optimum 37°C). The predominant isoprenoid quinone in the strain is menaquinone-7 and the peptidoglycan of the strain is meso-diaminopimelic acid. The major fatty acids of the strain are anteisio-C15:0, iso-C15:0, and, C16:0 (other components were < 10...
September 2016: Journal of Microbiology / the Microbiological Society of Korea
Xian Xia, Shijuan Wu, Yushan Han, Shuijiao Liao, Gejiao Wang
A Gram-staining-negative, rod-shaped, motile by gliding and facultative anaerobic bacterial strain, YS-25T, was isolated from sludge of a manganese mine. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain YS-25T formed a single branch within the strains of family Sphingobacteriaceae and showed low similarities to Pedobacter arcticus CCTCC AB 2010223T (91.7%), Pedobacter zeaxanthinifaciens TDMA-5T (91.5%), Pedobacter terricola DS-45T (90.9%), Pedobacter ureilyticus THG-T11T (90.9%), Pseudopedobacter beijingensis MCCC 1A01299T (90...
August 25, 2016: International Journal of Systematic and Evolutionary Microbiology
Lili Niu, Mengjie Xiong, Daochen Zhu, Lei Song, Tianyi Tang, Wenying Li
A novel Gram-stain-positive, strictly aerobic, and endospore-forming rod-shaped bacterial strain 7578-24T was isolated from the ripened Pu'er tea. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain 7578-24T clustered with the species of the genus Pullulanibacillus in the family Sporolactobacillaceae with 97.8-95.2 % sequence similarities and was most closely related to Pullulanibacillus pueri YN3T with a 97.8 % 16S rRNA gene sequence similarity. The DNA-DNA relatedness value between strain 7578-24T and P...
August 15, 2016: International Journal of Systematic and Evolutionary Microbiology
Yushan Han, Fujun Zhang, Qian Wang, Shixue Zheng, Wei Guo, Liang Feng, Gejiao Wang
A Gram-staining positive, strict aerobic, non-motile and rod-shaped bacterial strain, designated YS-17T, was isolated from soil in the Lengshuijiang antimony mine, Hunan province, P. R. China. Comparative 16S rRNA gene sequencing analysis clustered with the Flavihumibacter strains and strain YS-17T was most closely related to Flavihumibacter cheonanensis WS16T (97.2%)Flavihumibacter petaseus T41T (96.6%) and Flavihumibacter solisilvae 3-3T (96.5%). The level of DNA-DNA relatedness between strain YS-17T and F...
August 8, 2016: International Journal of Systematic and Evolutionary Microbiology
Jae-Jin Lee, Yeon Hee Lee, Su Jin Park, Sangyong Lim, Sun-Wook Jeong, Seung-Yeol Lee, Young-Je Cho, Myung Kyum Kim, Hee-Young Jung
A Gram-negative, long rod-shaped, and yellowish bacterium, designated as strain 15J17T(T), was isolated from sediment of the Han River in South Korea after exposure to 3 kGy of gamma radiation. The strain was catalase- and oxidase-positive and showed resistance to gamma radiation-D10 value (i.e., the dose required to reduce the bacterial population by 10-fold) of >4 kGy. Phylogenetic analysis based on the 16S rRNA gene sequence revealed that the strain belonged to the genus Spirosoma and showed moderate degrees of sequence similarity with related species (90...
November 2016: Current Microbiology
Yonghoon Kim, Bobae Kim, Keunsoo Kang, Tae-Young Ahn
A novel bacterial strain designated AA5T was isolated from sediment in a fishbowl. Cells were Gram-stain-negative, rod-shaped, and strictly aerobic, showing gliding motility. Strain AA5T was able to grow at 15-37 ºC, at pH 5.0-8.0, and in the absence of NaCl. The 16S rRNA gene sequence analysis of strain AA5T revealed that it was most closely related to species in the genus Sediminibacterium, showing the highest similarity to S. goheungense (96.6 %). Concordantly, a phylogenetic tree analysis based on the 16S rRNA gene sequences indicated that strain AA5T belongs to the genus Sediminibacterium...
August 4, 2016: International Journal of Systematic and Evolutionary Microbiology
Ji Hee Lee, Mi Sun Kim, Joo Won Kang, Keun Sik Baik, Chi Nam Seong
A non-motile, rod-shaped and pale-pink colored bacterium, designated strain WS71T, was isolated from freshwater collected from the Woopo Wetland (Republic of Korea). Cells were Gram-stain-negative, aerobic, catalase- positive and oxidase- negative. The major fatty acids were summed feature 3 (comprising C16:1 6c and/or C16:1 7c), iso-C17:0 3-OH, C16:0 and iso-C15:0. The strain contained menaquinone 7 (MK-7) and the DNA G+C content was 39.4±0.4 mol%. The major polar lipids were phosphatidylethanolamine and unknown amino lipid...
August 5, 2016: International Journal of Systematic and Evolutionary Microbiology
Dhiraj Kumar Chaudhary, Jaisoo Kim
During the study of bacterial community in forest soil of Kyonggi University, Suwon, South Korea, a glistening yellow-pigmented, Gram-stain-negative, aerobic, motile, and rod shaped bacterium, designated strain C-1-16T, was isolated. This strain was non-sporulating, catalase-negative, and oxidase-positive. It was able to grow at 20-42°C, pH 6.0-9.0, and 0-0.5% (w/v) NaCl concentration. This strain was taxonomically characterized by a polyphasic approach. Based on the results of 16S rRNA gene sequence analysis, strain C-1-16T formed a lineage within the family Chitinophagaceae of the phylum Bacteroidetes and closely related to genera Filimonas (93...
July 28, 2016: International Journal of Systematic and Evolutionary Microbiology
Janish Desai, Yi-Liang Liu, Hongli Wei, Weidong Liu, Tzu-Ping Ko, Rey-Ting Guo, Eric Oldfield
We report the first structure of heptaprenyl diphosphate synthase from Staphylococcus aureus (SaHepPPS), together with an investigation of its mechanism of action and inhibition. The protein is involved in the formation of menaquinone, a key electron transporter in many bacteria, including pathogens. SaHepPPS consists of a "catalytic " subunit (SaHepPPS-2) having two "DDXXD" motifs and a "regulatory" subunit (SaHepPPS-1) that lacks these motifs. High concentrations of the substrates, isopentenyl diphosphate and farnesyl diphosphate, inhibit the enzyme, which is also potently inhibited by bisphosphonates...
September 6, 2016: ChemMedChem
Jingwei Tang, Jing Huang, Zixu Qiao, Rui Wang, Gejiao Wang
Strain TBZ30T was isolated from soil of a heavy-metal contaminated paddy field. Cells of strain TBZ30T were Gram-staining negative, rod-shaped, non-motile and non-spore-forming. The isolate was strictly aerobic, pink-pigmented, catalase- and oxidase- positive and produces exopolysaccharides. Based on 16S rRNA gene phylogeny, strain TBZ30T belonged to the genus Mucilaginibacter and appeared most closely related to Mucilaginibacter gynuensis YC7003T (95.8%), Mucilaginibacter litoreus BR-18T (95.4%) and Mucilaginibacter mallensis MP1X4T (95...
July 13, 2016: International Journal of Systematic and Evolutionary Microbiology
Jun-Lian Gao, Pengbo Sun, Xu-Ming Wang, Tian-Lei Qiu, Fan-Yang Lv, Mei Yuan, Ming-Ming Yang, Jian-Guang Sun
A novel Gram-stain-negative, aerobic and rod-shaped bacterial strain designated 65T was isolated from surface-sterilized root tissue of maize, collected from Fangshan District of Beijing , People's Republic of China, and was subjected to a taxonomic study by using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain 65T belonged to the genus Dyadobacter and had highest 16S rRNA gene sequence similarity to Dyadobacter jiangsuensis CGMCC 1.12969T (99.1 %), Dyadobacter beijingensis CGMCC 1...
July 13, 2016: International Journal of Systematic and Evolutionary Microbiology
Mona Møller, Ingrid M Fange Gjelstad, Ingebjørg Baksaas, Tone Grande, Inger Reidun Aukrust, Christian A Drevon
We investigated the bioavailability of a synthetic form of the vitamin K2 molecule menaquinone-7 (MK-7) in a randomised single-blinded two-way cross-over study. Healthy subjects (20 - 66 years of age) took a single 180 μg dose of synthetic MK-7 or fermentation-derived MK-7, and serum MK-7 concentrations were monitored for 72 hours to calculate AUC(0 - 72 h) and Cmax. We also compared the biological effects of placebo, fermentation-derived MK-7 (90 μg) and 3 doses of synthetic MK-7(45, 90 and 180 μg) in a randomised double-blinded parallel study...
July 4, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Huiqin Huang, Fengzhao Feng, Min Liu, Fute Zhang, Qianguang Sun, Songyu Qin, Shixiang Bao
A Gram-stain-positive, facultatively anaerobic, endospore-forming, irregular rod-shaped bacterium, designated DB13260T, was isolated from tropical rainforest soil in Jianfengling Nature Reserve in Hainan, China. The isolate was found to grow with 0-4 % (w/v) NaCl, at 5-40 °C and pH 6.0-10.5, with an optimum of 0 % NaCl, 30-37 °C and pH 8.5-9.0, respectively. The predominant isoprenoid quinone was menaquinone 7 (MK-7), and the major fatty acids were anteiso-C15:0, iso-C16:0 and C16:0. The G+C content of the genomic DNA was 53...
June 30, 2016: International Journal of Systematic and Evolutionary Microbiology
Jae-Jin Lee, Myung-Suk Kang, Gyung Soon Kim, Chang Soek Lee, Sangyong Lim, Jidam Lee, Si Hyeon Roh, Hyerin Kang, Jung Min Ha, Sojung Bae, Hee-Young Jung, Myung Kyum Kim
A Gram-negative, non-motile, deep yellow colored and rod-shaped bacterium designated strain LCS9T was isolated from a soil sample at the tropical zone within the Ecorium of the National Institute of Ecology in Seocheon, central-western Korea. 16S rRNA gene sequence analysis showed that strain LCS9T clustered with members of the genus Flavisolibacter of the family Chitinophagaceae, phylum Bacteroidetes. Sequence similarities between strain LCS9T and type strains of the genus Flavisolibacter ranged from 94.6 to 94...
June 3, 2016: International Journal of Systematic and Evolutionary Microbiology
Min-Hsiung Pan, Katarzyna Maresz, Pei-Sheng Lee, Jia-Ching Wu, Chi-Tang Ho, Janusz Popko, Dilip S Mehta, Sidney J Stohs, Vladimir Badmaev
Circulatory markers of low-grade inflammation such as tumor necrosis factor-alpha (TNF-α), interleukin-1 alpha (IL-1α), and interleukin-1 beta (IL-1β) positively correlate with endothelial damage, atheroma formation, cardiovascular disease, and aging. The natural vitamin K2-menaquinone-7 (MK-7) added to the cell culture of human monocyte-derived macrophages (hMDMs) at the same time as toll-like receptor (TLR) agonists did not influence the production of TNF-α. When the cells were pretreated up to 6 h with MK-7 before treatment with TLR agonists, MK-7 did not inhibit significantly the production of TNF-α after the TLR activation...
July 2016: Journal of Medicinal Food
Akira Yokota, Fitria Ningsih, Dafina Ghossani Nurlaili, Yasuteru Sakai, Shuhei Yabe, Ariyanti Oetari, Iman Santoso, Wellyzar Sjamsuridzal
A Gram-stain-positive, endospore-forming, aerobic and thermophilic bacterium, designated strain LC2-13AT, was isolated from Cisolok geyser, West Java, Indonesia, at 50 °C. The isolate was rod-shaped and motile by means of peritrichous flagella. The major cellular fatty acids were iso-C16 : 0, C16 : 0 and anteiso-C15 : 0 and the major quinone was menaquinone 7. The major polar lipids were diphosphatidylglycerol, phosphatidylglycerol and phosphatidylethanolamine. The genomic DNA G+C content was 56...
August 2016: International Journal of Systematic and Evolutionary Microbiology
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