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Lithium neuroprotective

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https://www.readbyqxmd.com/read/29203398/metyrapone-prevents-acute-glucose-hypermetabolism-and-short-term-brain-damage-induced-by-intrahippocampal-administration-of-4-aminopyridine-in-rats
#1
Luis García-García, Rubén Fernández de la Rosa, Mercedes Delgado, Ágata Silván, Pablo Bascuñana, Jens P Bankstahl, Francisca Gomez, Miguel A Pozo
Intracerebral administration of the potassium channel blocker 4-aminopyridine (4-AP) triggers neuronal depolarization and intense acute seizure activity followed by neuronal damage. We have recently shown that, in the lithium-pilocarpine rat model of status epilepticus, a single administration of metyrapone, an inhibitor of the 11β-hydroxylase enzyme, had protective properties of preventive nature against signs of brain damage and neuroinflammation. Herein, our aim was to investigate to which extent, pretreatment with metyrapone (150 mg/kg, i...
December 1, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29200666/prevention-of-memory-impairment-and-neurotrophic-factors-increased-by-lithium-in-wistar-rats-submitted-to-pneumococcal-meningitis-model
#2
Lutiana R Simões, Roberta R E S Abreu, Jaqueline S Generoso, Jéssica A Goularte, Allan Collodel, Vijayasree Vayalanellore Giridharan, Anitha Christy Sigamani Arumanayagam, Samira S Valvassori, João Quevedo, Tatiana Barichello
The aim of this study was to investigate the effects of lithium on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) expression in the hippocampus and on memory in experimental pneumococcal meningitis. The mood-stabilizer lithium is known as a neuroprotective agent with many effects on the brain. In this study, animals received either artificial cerebrospinal fluid or Streptococcus pneumoniae suspension at a concentration of 5 × 109 CFU/mL...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29188027/recent-advances-in-the-understanding-and-management-of-bipolar-disorder-in-adults
#3
REVIEW
Janusz K Rybakowski
This article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermore, a poly-gene-environmental interaction in the development of the illness has been demonstrated. For the management of BD, new drugs with putative mood-stabilizing properties have been introduced in the past two decades...
2017: F1000Research
https://www.readbyqxmd.com/read/29183826/developmental-ethanol-induced-sleep-fragmentation-behavioral-hyperactivity-cognitive-impairment-and-parvalbumin-cell-loss-are-prevented-by-lithium-co-treatment
#4
M Lewin, M Ilina, J Betz, K Masiello, M Hui, D A Wilson, M Saito
Developmental ethanol exposure is a well-known cause of lifelong cognitive deficits, behavioral hyperactivity, emotional dysregulation, and more. In healthy adults, sleep is thought to have a critical involvement in each of these processes. Our previous work has demonstrated that some aspects of cognitive impairment in adult mice exposed at postnatal day 7 (P7) to ethanol (EtOH) correlate with slow-wave sleep (SWS) fragmentation (Wilson et al., 2016). We and others have also previously demonstrated that co-treatment with LiCl on the day of EtOH exposure prevents many of the anatomical and physiological impairments observed in adults...
November 26, 2017: Neuroscience
https://www.readbyqxmd.com/read/29103043/examining-the-relationship-between-trace-lithium-in-drinking-water-and-the-rising-rates-of-age-adjusted-alzheimer-s-disease-mortality-in-texas
#5
Val Andrew Fajardo, Val Andrei Fajardo, Paul J LeBlanc, Rebecca E K MacPherson
BACKGROUND: Alzheimer's disease (AD) mortality rates have steadily increased over time. Lithium, the current gold standard treatment for bipolar disorder, can exert neuroprotective effects against AD. OBJECTIVE: We examined the relationship between trace levels of lithium in drinking water and changes in AD mortality across several Texas counties. METHODS: 6,180 water samples from public wells since 2007 were obtained and averaged for 234 of 254 Texas counties...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29102713/the-anticonvulsant-activity-and-cerebral-protection-of-chronic-lithium-chloride-via-nmda-receptor-nitric-oxide-and-phospho-erk
#6
Razieh Mohammad Jafari, Mohammad Hossein Ghahremani, Nastaran Rahimi, Amir Shadboorestan, Amir Rashidian, Jamileh Esmaeili, Shahram Ejtemaei Mehr, Ahmad Reza Dehpour
The underlying mechanisms for the neuroprotective effects of lithium chloride in neurodegenerative diseases such as seizures remain unknown. In present study the downstream signaling pathway of phospho-ERK/NMDA receptors/nitric oxide has been studied. For this purpose, acute and chronic effect of lithium in seizure animal model and the interaction of NMDA receptor antagonist (MK-801) and neuronal nitric oxide synthase (nNOS) inhibitor (7-NI) with these neuroprotection has been studied. Acute lithium administration showed pro-convulsive properties in pentylenetetrazole (PTZ)-induced seizure model while chronic treatment increased the seizure threshold significantly...
November 2, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29055468/evaluation-of-lithium-serum-level-in-multiple-sclerosis-patients-a-neuroprotective-element
#7
Atieh Karimi, Kobra Bahrampour, Mohammad Amin Momeni Moghaddam, Gholamreza Asadikaram, Ghasem Ebrahimi, Masoud Torkzadeh-Mahani, Mojdeh Esmaeili Tarzi, Mohammad Hadi Nematollahi
INTRODUCTION: It has been claimed that continuous and high production of nitric oxide (NO) and its metabolites may be involved in the pathogenesis of several neurological disorders such as multiple sclerosis. A number of studies have demonstrated that lithium regulates NO levels in disorders of the central nervous system. The aim of this study was to investigate whether NO as a marker of disease activity is correlated with lithium deficiency in relapsing remitting multiple sclerosis (RR-MS)...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28965429/clinically-relevant-treatment-considerations-regarding-lithium-use-in-bipolar-disorder
#8
REVIEW
Tara Richardson, Matthew Macaluso
The goal of this paper is to provide a practical, clinically oriented review of lithium, a salt widely used to treat mania since the 1870s and formally approved as a mood stabilizer in 1970. Although lithium is still considered a first-line treatment for bipolar mania in most practice guidelines, its use may be overshadowed by newer psychotropic medications. Areas covered: This paper addresses the historical use of lithium, modern indications for its use, guidelines for prescribing and monitoring continued lithium use, drug-drug interactions, and pharmacodynamics/pharmacokinetic properties...
November 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28942448/antagomirs-targeting-microrna-134-increase-limk1-levels-after-experimental-seizures-in-vitro-and-in-vivo
#9
Jiahang Sun, Xiaoying Gao, Dawei Meng, Yang Xu, Xichun Wang, Xin Gu, Mian Guo, Xiaodong Shao, Hongwen Yan, Chuanlu Jiang, Yongri Zheng
BACKGROUND: MiR-134 is enriched in dendrites of hippocampal neurons and plays crucial roles in the progress of epilepsy. The present study aims to investigate the effects of antagomirs targeting miroRNA-134 (Ant-134) on limk1 expression and the binding of miR-134 and limk1 in experimental seizure. METHODS: Status epilepticus (SE) rat model was established by lithium chloride-pilocarpine injection and was treated with Ant-134 by intracerebroventricular injection...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28885630/from-direct-to-indirect-lithium-targets-a-comprehensive-review-of-omics-data
#10
REVIEW
Magali Roux, Anthony Dosseto
Metal ions are critical to a wide range of biological processes. Among them, lithium (Li) has been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet to grasp the extent of its role in biological processes, despite its molecular targets having been extensively studied. Here we review a wide range of transcriptomic, proteomic and metabolomic studies in order to obtain a full picture of Li effects at various levels. Multifarious patterns of Li-regulated genes, proteins and metabolites are identified...
October 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28852438/effect-of-eugenol-on-lithium-pilocarpine-model-of-epilepsy-behavioral-histological-and-molecular-changes
#11
Sara Joushi, Mahmoud Elahdadi Salmani
OBJECTIVES: Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment. Eugenol is the main component of the essential oil extracted from cloves with the potential to modulate neuronal excitability. Therefore, we investigated the effect of eugenol on convulsive behavior, oxidative stress, and histological changes of the hippocampus in lithium-pilocarpine model of epilepsy...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28841161/disease-modifying-effects-of-the-spider-toxin-parawixin2-in-the-experimental-epilepsy-model
#12
Lívea Dornela Godoy, José Luiz Liberato, Marcus Vinícius Batista Celani, Leonardo Gobbo-Neto, Norberto Peporine Lopes, Wagner Ferreira Dos Santos
(1) Background: Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. It is also the one with the highest percentage of drug-resistance to the current available anti-epileptic drugs (AED). Additionaly, most antiepileptic drugs are only able to control seizures in epileptogenesis, but do not decrease the hippocampal neurodegenerative process. TLE patients have a reduced population of interneuronal cells, which express Parvalbumin (PV) proteins. This reduction is directly linked to seizure frequency and severity in the chronic period of epilepsy...
August 25, 2017: Toxins
https://www.readbyqxmd.com/read/28783519/antimanic-activity-of-minocycline-in-a-gbr12909-induced-model-of-mania-in-mice-possible-role-of-antioxidant-and-neurotrophic-mechanisms
#13
Ana Isabelle G de Queiroz, Adriano José Maia Chaves Filho, Tatiane da Silva Araújo, Camila Nayane Carvalho Lima, Michel de Jesus Souza Machado, André F Carvalho, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, João Quevedo, Danielle Macedo
BACKGROUND: Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the repeated administration of GBR12909 and its prevention/reversal by the mood stabilizing drugs, lithium (Li) and valproate (VAL) as well as by the neuroprotective drug, minocycline (Mino)...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28687854/neuroprotective-effects-of-vitamin-d-alone-or-in-combination-with-lamotrigine-against-lithium-pilocarpine-model-of-status-epilepticus-in-rats
#14
Amal M Mahfoz, Ali F Abdel-Wahab, Mohamed A Afify, Naiyer Shahzad, Ibrahim A A Ibrahim, Naser A ElSawy, Ghazi A Bamagous, Saeed S Al Ghamdi
Status epilepticus (SE) is considered one of the major serious forms of epilepsy with high mortality rate. Since the currently available antiepileptic drugs have low efficacy and high adverse effects, new more efficient and safe therapies are critically needed. There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Recent studies have shown significant prophylactic and therapeutic potential of vitamin D (vit-D) use in many neurological disorders...
July 7, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28638078/the-stress-response-factor-daf-16-foxo-is-required-for-multiple-compound-families-to-prolong-the-function-of-neurons-with-huntington-s-disease
#15
Francesca Farina, Emmanuel Lambert, Lucie Commeau, François-Xavier Lejeune, Nathalie Roudier, Cosima Fonte, J Alex Parker, Jacques Boddaert, Marc Verny, Etienne-Emile Baulieu, Christian Neri
Helping neurons to compensate for proteotoxic stress and maintain function over time (neuronal compensation) has therapeutic potential in aging and neurodegenerative disease. The stress response factor FOXO3 is neuroprotective in models of Huntington's disease (HD), Parkinson's disease and motor-neuron diseases. Neuroprotective compounds acting in a FOXO-dependent manner could thus constitute bona fide drugs for promoting neuronal compensation. However, whether FOXO-dependent neuroprotection is a common feature of several compound families remains unknown...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28624183/the-neuroprotective-effect-of-perampanel-in-lithium-pilocarpine-rat-seizure-model
#16
Ting Wu, Katsutoshi Ido, Yoshihide Osada, Sadaharu Kotani, Akira Tamaoka, Takahisa Hanada
PURPOSE: Status epilepticus (SE) causes irreversible neurodegeneration if not terminated quickly. Perampanel (PER), a potent AMPA receptor antagonist, has previously been shown to terminate seizures in the lithium-pilocarpine SE model. In the present study, we assessed whether PER would also prevent neuronal damage in this model. METHODS: SE was induced in rats using lithium chloride and pilocarpine. Initiation of SE was defined as continuous seizures that exhibited as rearing accompanied by bilateral forelimb clonus (Racine score 4)...
June 16, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28621334/telomere-length-and-bipolar-disorder
#17
Timothy R Powell, Danai Dima, Sophia Frangou, Gerome Breen
Variation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD). We used quantitative polymerase chain reactions and a telomere-sequence to single-copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal smears from 63 patients with BD, 74 first-degree relatives (49 relatives had no lifetime psychopathology and 25 had a non-BD mood disorder) and 80 unrelated healthy individuals...
June 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28545972/lithium-alleviates-neurotoxic-prion-peptide-induced-synaptic-damage-and-neuronal-death-partially-by-the-upregulation-of-nuclear-target-rest-and-the-restoration-of-wnt-signaling
#18
Zhiqi Song, Wei Yang, Xiangmei Zhou, Lifeng Yang, Deming Zhao
Prion diseases are a group of infectious neurodegenerative diseases characterized by multiple neuropathological hallmarks, including accumulation of PrP(Sc), synaptic damage, and neuronal death. We previously reported that the repressor element 1-silencing transcription factor (REST), a novel neuroprotective marker in neurodegeneration, protects neurons against neurotoxic peptide (PrP106-126)-induced neurotoxicity, but fails to maintain survival following prolonged exposure to PrP106-126. Because Wnt signaling partially induces REST and is activated by lithium, we investigated the effects of lithium on REST in prion diseases...
May 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28511952/lithium-ameliorates-lipopolysaccharide-induced-neurotoxicity-in-the-cortex-and-hippocampus-of-the-adult-rat-brain
#19
Muhammad Sohail Khan, Tahir Ali, Muhammad Noman Abid, Myeung Hoon Jo, Amjad Khan, Min Woo Kim, Gwang Ho Yoon, Eun Woo Cheon, Shafiq Ur Rehman, Myeong Ok Kim
Lithium an effective mood stabilizer, primary used in the treatment of bipolar disorders, has been reported as a protective agent in various neurological disorders. In this study, we examined the neuroprotective role of lithium chloride (LiCl) against lipopolysaccharide (LPS) in the cortex and hippocampus of the adult rat brain. We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α)...
May 13, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28495374/metyrapone-prevents-brain-damage-induced-by-status-epilepticus-in-the-rat-lithium-pilocarpine-model
#20
Luis García-García, Ahmed A Shiha, Rubén Fernández de la Rosa, Mercedes Delgado, Ágata Silván, Pablo Bascuñana, Jens P Bankstahl, Francisca Gomez, Miguel A Pozo
The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage. Stress and glucocorticoids markedly contribute to exacerbate neuronal damage induced by seizures but the underlying mechanisms are poorly understood. Herein we sought to investigate whether a single administration of metyrapone (150 mg/kg, i.p.), an 11β-hydroxylase inhibitor, enzyme involved in the peripheral and central synthesis of corticosteroids, had neuroprotective properties in this model...
May 8, 2017: Neuropharmacology
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