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https://www.readbyqxmd.com/read/28441607/toxicity-assessment-of-zno-decorated-au-nanoparticles-in-the-mediterranean-clam-ruditapes-decussatus
#1
Badreddine Sellami, Amine Mezni, Abdelhafidh Khazri, Imen Bouzidi, Wiem Saidani, David Sheehan, Hamouda Beyrem
The synthesis of hybrid nanomaterials has greatly increased in recent years due to their special physical and chemical properties. However, information regarding the environmental toxicity associated with these chemicals is limited, in particular in the aquatic environment. In the present study, an experiment was performed in which the marine bivalve (Ruditapes decussatus) was exposed for 14days to 2 concentrations of zinc oxide-decorated Au nanoparticles (Au-ZnONPs: Au-ZnONP50=50μg/L; Au-ZnONP100=100μg/L)...
April 15, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28441601/improving-understanding-of-mixed-land-use-watershed-suspended-sediment-regimes-mechanistic-progress-through-high-frequency-sampling
#2
Elliott Kellner, Jason A Hubbart
Given the importance of suspended sediment to biogeochemical functioning of aquatic ecosystems, and the increasing concern of mixed-land-use effects on pollutant loading, there is an urgent need for research that quantitatively characterizes spatiotemporal variation of suspended sediment dynamics in contemporary watersheds. A study was conducted in a representative watershed of the central United States utilizing a nested-scale experimental watershed design, including five gauging sites (n=5) partitioning the catchment into five sub-watersheds...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441569/the-cytoskeleton-autophagy-connection
#3
REVIEW
David J Kast, Roberto Dominguez
Actin cytoskeleton dynamics play vital roles in most forms of intracellular trafficking by promoting the biogenesis and transport of vesicular cargoes. Mounting evidence indicates that actin dynamics and membrane-cytoskeleton scaffolds also have essential roles in macroautophagy, the process by which cellular waste is isolated inside specialized vesicles called autophagosomes for recycling and degradation. Branched actin polymerization is necessary for the biogenesis of autophagosomes from the endoplasmic reticulum (ER) membrane...
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28441496/room-temperature-ferromagnetism-in-2d-fe2si-nanosheet-with-enhanced-spin-polarization-ratio
#4
Yingjie Sun, Zhiwen Zhuo, Xiaojun Wu, Jinlong Yang
Searching experimental feasible two-dimensional (2D) ferromagnetic crystals with large spin-polarization ratio, high Curie temperature and large magnetic anisotropic energy is one key to develop next-generation spintronic nano-devices. Here, 2D Fe2Si nanosheet, one counterpart of Hapkeite mineral discovered in meteorite, with novel magnetism is proposed on the basis of first-principles calculations. 2D Fe2Si crystal has a slightly buckled triangular lattice with planar hexacoordinated Si and Fe atoms. The spin-polarized calculations with hybrid HSE06 function method indicate that 2D Fe2Si is a ferromagnetic half metal at its ground state with 100% spin-polarization ratio at Fermi energy level...
April 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28441487/the-isomeric-preference-of-an-atypical-dopamine-transporter-inhibitor-contributes-to-its-selection-of-the-transporter-conformation
#5
Ara M Abramyan, Sebastian Stolzenberg, Zheng Li, Claus J Loland, Frank Noé, Lei Shi
Cocaine, a widely abused psychostimulant, inhibits the dopamine transporter (DAT) by trapping the protein in an outward-open conformation, whereas atypical DAT inhibitors such as benztropine have low abuse liability and prefer less outward-open conformations. Here, we use a spectrum of computational modeling and simulation approaches to obtain the underlying molecular mechanism in atomistic detail. Interestingly, our quantum mechanical calculations and molecular dynamics (MD) simulations suggest that a benztropine derivative JHW007 prefers a different stereoisomeric conformation of tropane in binding to DAT compared to that of a cocaine derivative, CFT...
April 25, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28441467/distribution-of-mammal-functional-diversity-in-the-neotropical-realm-influence-of-land-use-and-extinction-risk
#6
José F González-Maya, Enrique Martínez-Meyer, Rodrigo Medellín, Gerardo Ceballos
Functional diversity represents a measure of diversity that incorporates the role of species in an ecosystem, and therefore its dynamics and resilience. Assessing its drivers and spatial variation represents an important step forward in our understanding of functional ecosystem dynamics and it is also necessary to achieve a comprehensive conservation planning. In this paper, we assessed mammal functional diversity for the 218 ecoregions within the Neotropical realm. We evaluated the overall influence and spatial variation of species richness, ecoregion extent, intervention and species at risk on functional diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28441354/design-and-development-of-a-three-component-force-sensor-for-milling-process-monitoring
#7
Yingxue Li, Yulong Zhao, Jiyou Fei, Yafei Qin, You Zhao, Anjiang Cai, Song Gao
A strain-type three-component table dynamometer is presented in this paper, which reduces output errors produced by cutting forces imposed on the different milling positions of a workpiece. A sensor structure with eight parallel elastic beams is proposed, and sensitive regions and Wheastone measuring circuits are also designed in consideration of eliminating the influences of the eccentric forces. To evaluate the sensor decoupling performance, both of the static calibration and dynamic milling test were implemented in different positions of the workpiece...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28441081/comparison-of-size-modulation-standard-automated-perimetry-and-conventional-standard-automated-perimetry-with-a-10-2-test-program-in-glaucoma-patients
#8
Kazunori Hirasawa, Natsumi Takahashi, Tsukasa Satou, Masayuki Kasahara, Kazuhiro Matsumura, Nobuyuki Shoji
PURPOSE: This prospective observational study compared the performance of size modulation standard automated perimetry with the Octopus 600 10-2 test program, with stimulus size modulation during testing, based on stimulus intensity and conventional standard automated perimetry, with that of the Humphrey 10-2 test program in glaucoma patients. METHODS: Eighty-seven eyes of 87 glaucoma patients underwent size modulation standard automated perimetry with Dynamic strategy and conventional standard automated perimetry using the SITA standard strategy...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28440948/novel-reduction-sensitive-micellar-nanoparticles-assembled-from-rituximab-doxorubicin-conjugates-as-smart-and-intuitive-drug-delivery-systems-for-the-treatment-of-non-hodgkin-s-lymphoma
#9
Huabin Yin, Tong Meng, Ling Shu, Min Mao, Lei Zhou, Haiyan Chen, Dianwen Song
In this study, a novel reduction-sensitive drug delivery system, the Rituximab-Doxorubicin (RTX-DOX) micellar nanoparticle (RDMN), was specially designed for targeted delivery and release of DOX in Non-Hodgkin's Lymphoma (NHL) cells. The RDMN was fabricated by self-assembling of amphiphilic RTX-DOX conjugates (RDCs), which were synthesized by conjugating the hydrophilic Fab fragments of RTX (an anti-CD20 monoclonal antibody) and hydrophobic DOXs by a reduction-responsive linker, 3-(2-Pyridyldithio) propionyl hydrazide (PDPH)...
April 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28440813/instability-of-default-mode-network-connectivity-in-major-depression-a-two-sample-confirmation-study
#10
T Wise, L Marwood, A M Perkins, A Herane-Vives, R Joules, D J Lythgoe, W-M Luh, S C R Williams, A H Young, A J Cleare, D Arnone
Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in connectivity strength over time in major depression. We assessed stability of connectivity in major depression between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), key nodes in the DMN that are implicated in ruminative cognitions...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28440643/field-calibration-of-xad-based-passive-air-sampler-on-the-tibetan-plateau-wind-influence-and-configuration-improvement
#11
Ping Gong, Xiao-Ping Wang, Xiande Liu, Frank Wania
The passive air sampler based on XAD-2 resin (XAD-PAS) has proven useful for collecting atmospheric persistent organic pollutants (POPs) in remote regions. Whereas laboratory studies have shown that, due to the open bottom of its housing, the passive sampling rate (PSR) of the XAD-PAS is susceptible to wind and other processes causing air turbulence, the sampler has not been calibrated in the field at sites experiencing high winds. In this study, the PSRs of the XAD-PAS were calibrated at three sites on the Tibetan Plateau, covering a wide range in temperature (T), pressure (P) and wind speed (v)...
April 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28440392/suppressive-role-of-diallyl-trisul%C3%AF-de-in-the-activated-platelet-mediated-hematogenous-metastasis-of-mda-mb-231-human-breast-cancer-cells
#12
Yuping Liu, Yang Zhao, Yingyu Wang, Pingting Zhu, Zhonghong Wei, Siliang Wang, Li Tao, Zhaoguo Liu, Hongyan Wu, Xiaobo Sheng, Yin Lu
Accumulating evidence has indicated that garlic consumption may reduce the risk of developing several types of cancer, and extensive studies have revealed the effects of its bioactive component, diallyl trisulfide (DATS), on the proliferation and apoptosis of tumor cells. The present study was undertaken to examine whether DATS affects hematogenous metastasis. In view of the dynamic crosstalk interplayed by tumor cells and platelets in hematogenous metastasis, we attempted to demonstrate the role of DATS in the metastatic behavior of MDA-MB-231 human breast cancer cells, which were co-incubated with activated platelets...
April 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28440386/effect-of-chemical-structure-of-s-nitrosothiols-on-nitric-oxide-release-mediated-by-the-copper-sites-of-a-metal-organic-framework-based-environment
#13
Kiara Taylor-Edinbyrd, Tanping Li, Revati Kumar
The effect of chemical structure of different biologically compatible S-nitrosothiols on the solvation environment at catalytic copper sites in a metal organic framework (MOF) suspended in a solution of ethanol is probed using computational methods. The use of a copper based MOF as a storage vehicle and catalyst (copper sites of the MOF) in the controlled and sustained release of chemically stored nitric oxide (NO) from S-nitrosocysteine has been shown to occur both experimentally and computationally [J. Am...
April 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28440282/understanding-the-rising-phase-of-the-pm2-5-concentration-evolution-in-large-china-cities
#14
Baolei Lv, Jun Cai, Bing Xu, Yuqi Bai
Long-term air quality observations are seldom analyzed from a dynamic view. This study analyzed fine particulate matter (PM2.5) pollution processes using long-term PM2.5 observations in three Chinese cities. Pollution processes were defined as linearly growing PM2.5 concentrations following the criteria of coefficient of determination R(2) > 0.8 and duration time T ≥ 18 hrs. The linear slopes quantitatively measured pollution levels by PM2.5 concentrations rising rates (PMRR, μg/(m(3)·hr))...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439461/quantitative-assessment-of-fibroblast-growth-factor-receptor-1-expression-in-neurons-and-glia
#15
Lisha Choubey, Jantzen C Collette, Karen Müller Smith
BACKGROUND: Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS). For example, the FGFR1 receptor is important for proliferation and fate specification of radial glial cells in the cortex and hippocampus, oligodendrocyte proliferation and regeneration, midline glia morphology and soma translocation, Bergmann glia morphology, and cerebellar morphogenesis. In addition, FGFR1 signaling in astrocytes is required for postnatal maturation of interneurons expressing parvalbumin (PV)...
2017: PeerJ
https://www.readbyqxmd.com/read/28439075/switch-from-ambient-to-focal-processing-mode-explains-the-dynamics-of-free-viewing-eye-movements
#16
Junji Ito, Yukako Yamane, Mika Suzuki, Pedro Maldonado, Ichiro Fujita, Hiroshi Tamura, Sonja Grün
Previous studies have reported that humans employ ambient and focal modes of visual exploration while they freely view natural scenes. These two modes have been characterized based on eye movement parameters such as saccade amplitude and fixation duration, but not by any visual features of the viewed scenes. Here we propose a new characterization of eye movements during free viewing based on how eyes are moved from and to objects in a visual scene. We applied this characterization to data obtained from freely-viewing macaque monkeys...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439032/inactivation-of-transcriptional-regulators-during-within-household-evolution-of-escherichia-coli
#17
Dagmara I Kisiela, Matthew Radey, Sandip Paul, Stephen Porter, Kseniya Polukhina, Veronika Tchesnokova, Sofiya Shevchenko, Diana Chan, Maliha Aziz, Timothy J Johnson, Lance B Price, James R Johnson, Evgeni V Sokurenko
We analyzed the within-household evolution of two household-associated Escherichia coli strains from pandemic clonal group ST131-H30, using isolates recovered from five individuals within two families, each of which had a distinct strain. Family 1's strain was represented by a urine isolate from the index patient (older sister) with recurrent cystitis, and a blood isolate from her younger sister with fatal urosepsis. Family 2's strain was represented by a urine isolate from the index patient (father) with pyelonephritis and renal abscesses, blood and kidney drainage isolates from the daughter with emphysematous pyelonephritis, and urine and fecal isolates from the mother with cystitis...
April 24, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28438701/unique-parallel-radiations-of-high-mountainous-species-of-the-genus-sedum-crassulaceae-on-the-continental-island-of-taiwan
#18
Takuro Ito, Chih-Chieh Yu, Koh Nakamura, Kuo-Fang Chung, Qin-Er Yang, Cheng-Xin Fu, Zhe-Chen Qi, Goro Kokubugata
We explored the temporal and spatial diversification of the plant genus Sedum L. (Crassulaceae) in Taiwan based on molecular analysis of nrITS and cpDNA sequences from East Asian Sedum members. Our phylogenetic and ancestral area reconstruction analysis showed that Taiwanese Sedum comprised two lineages that independently migrated from Japan and Eastern China. Furthermore, the genetic distances among species in these two clades were smaller than those of other East Asian Sedum clades, and the Taiwanese members of each clade occupy extremely varied habitats with similar niches in high-mountain regions...
April 21, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28438665/effective-connectivity-gateways-to-the-theory-of-mind-network-in-processing-communicative-intention
#19
Marco Tettamanti, Matilde M Vaghi, Bruno G Bara, Stefano F Cappa, Ivan Enrici, Mauro Adenzato
An Intention Processing Network (IPN), involving the medial prefrontal cortex, precuneus, bilateral posterior superior temporal sulcus, and temporoparietal junctions, plays a fundamental role in comprehending intentions underlying action goals. In a previous fMRI study, we showed that, depending on the linguistic or extralinguistic (gestural) modality used to convey the intention, the IPN is complemented by activation of additional brain areas, reflecting distinct modality-specific input gateways to the IPN...
April 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28438102/mapping-a-careflow-network-to-assess-the-connectedness-of-connected-health
#20
Noel Carroll, Ita Richardson
Connected Health is an emerging and rapidly developing field which has the potential to transform healthcare service systems by increasing its safety, quality and overall efficiency. From a healthcare perspective, process improvement models have mainly focused on the static workflow viewpoint. The objective of this article is to study and model the dynamic nature of healthcare delivery, allowing us to identify where potential issues exist within the service system and to examine how Connected Health technological solutions may support service efficiencies...
April 1, 2017: Health Informatics Journal
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