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https://www.readbyqxmd.com/read/26379421/does-the-type-of-treatment-have-an-influence-on-utility-values-in-a-glaucoma-population
#1
Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Sirley Maria Freitas, Alfredo Chaoubah
PURPOSE: To assess the impact of glaucoma therapy on utility values in a glaucoma population. METHODS: A cross-sectional study of consecutive glaucoma patients was conducted. Utility values were obtained using the time trade-off method. Visual function variables (visual acuity and mean deviation in the better eye) and sociodemographic and clinical characteristics (age, sex, race, educational level, type of glaucoma, current and past glaucoma treatments, and comorbidities) were also obtained for statistical analysis...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26168898/melatonin-minocycline-and-ascorbic-acid-reduce-oxidative-stress-and-viral-titers-and-increase-survival-rate-in-experimental-venezuelan-equine-encephalitis
#2
Nereida Valero, Jesús Mosquera, Sirley Alcocer, Ernesto Bonilla, Jenny Salazar, Melchor Álvarez-Mon
Venezuelan equine encephalitis (VEE) virus causes an acute central nervous system infection in human and animals. Melatonin (MLT), minocycline (MIN) and ascorbic acid (AA) have been shown to have antiviral activities in experimental infections; however, the mechanisms involved are poorly studied. Therefore, the aim of this study was to determine the effects of those compounds on the viral titers, NO production and lipid peroxidation in the brain of mice and neuroblastoma cultures infected by VEE virus. Infected mouse (10 LD50) were treated with MLT (500 μg/kg bw), MIN (50mg/kg bw) or AA (50mg/kg bw)...
October 5, 2015: Brain Research
https://www.readbyqxmd.com/read/25884712/auditory-steady-state-responses-in-school-aged-children-a-pilot-study
#3
Luciana Macedo de Resende, Sirley Alves da Silva Carvalho, Thamara Suzi Dos Santos, Filipe Ibraim Abdo, Matheus Romão, Marcela Cristina Ferreira, Carlos Julio Tierra-Criollo
BACKGROUND: The use of Auditory Steady-State Responses (ASSRs) for auditory screening in school-aged children, particularly in children who are difficult to test and children with disabilities, has not been explored yet. This pilot study investigated the use of ASSR for auditory screening in school-aged children. MATERIALS AND METHODS: A cross-sectional pilot study of 23 children aged 9 to 11 with normal-hearing thresholds and seven age-matched children with permanent moderate-to-profound bilateral hearing loss were examined...
2015: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/25779833/auditory-steady-state-responses-in-school-aged-children-a-pilot-study
#4
Luciana Macedo de Resende, Sirley Alves da Silva Carvalho, Thamara Suzi Dos Santos, Filipe Ibraim Abdo, Matheus Romão, Marcela Cristina Ferreira, Carlos Julio Tierra-Criollo
BACKGROUND: The use of Auditory Steady-State Responses (ASSRs) for auditory screening in school-aged children, particularly in children who are difficult to test and children with disabilities, has not been explored yet. This pilot study investigated the use of ASSR for auditory screening in school-aged children. MATERIALS AND METHODS: A cross-sectional pilot study of 23 children aged 9 to 11 with normal-hearing thresholds and seven age-matched children with permanent moderate-to-profound bilateral hearing loss were examined...
December 2015: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/25382426/hearing-health-network-a-spatial-analysis
#5
Camila Ferreira de Rezende, Sirley Alves da Silva Carvalho, Fernanda Jorge Maciel, Raimundo de Oliveira Neto, Darlan Venâncio Thomaz Pereira, Stela Maris Aguiar Lemos
INTRODUCTION: In order to meet the demands of the patient population with hearing impairment, the Hearing Health Care Network was created, consisting of primary care actions of medium and high complexity. Spatial analysis through geoprocessing is a way to understand the organization of such services. OBJECTIVE: To analyze the organization of the Hearing Health Care Network of the State of Minas Gerais. METHODS: Cross-sectional analytical study using geoprocessing techniques...
May 2015: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/25166050/normocalcemic-primary-hyperparathyroidism-long-term-follow-up-associated-with-multiple-adenomas
#6
Larissa Pimentel, Sirley Portela, Alyne Loureiro, Francisco Bandeira
Normocalcemic primary hyperparathyroidism (NPHPT) is a condition characterized by elevation of the parathyroid hormone (PTH) in the presence of normal serum calcium and the absence of secondary causes. The case described illustrates the long-term follow-up of a postmenopausal woman with NPHPT patient who progressed with multiple adenomas. This case reports a 77-year-old female who has chronic generalized pain and osteoporosis. Her initial serum PTH was 105 pg/mL, with total serum calcium of 9.6 mg/dL, albumin 4...
July 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/25057514/food-safety-control-of-zeranol-through-voltammetric-immunosensing-on-au-pt-bimetallic-nanoparticle-surfaces
#7
Matías Regiart, Sirley V Pereira, Viviana G Spotorno, Franco A Bertolino, Julio Raba
This study reports an accurate and sensitive strategy for zeranol (ZER) determination in bovine urine samples. ZER is a mycotoxin widely used as a synthetic growth promoter in the livestock production whose residues could present a potential risk for human health. Therefore, its use as an animal feed additive has been banned in most countries. ZER determination was accomplished using an electrochemical system in which bimetallic Au-Pt nanoparticles (Au-PtNPs) were electro-synthesized on a screen-printed carbon electrode (SPCE)...
September 21, 2014: Analyst
https://www.readbyqxmd.com/read/24983904/silica-nanoparticle-based-microfluidic-immunosensor-with-laser-induced-fluorescence-detection-for-the-quantification-of-immunoreactive-trypsin
#8
Marco A Seia, Patricia W Stege, Sirley V Pereira, Irma E De Vito, Julio Raba, Germán A Messina
The purpose of this study was to develop a silica nanoparticle-based immunosensor with laser-induced fluorescence (LIF) as a detection system. The proposed device was applied to quantify the immunoreactive trypsin (IRT) in cystic fibrosis (CF) newborn screening. A new ultrasonic procedure was used to extract the IRT from blood spot samples collected on filter papers. After extraction, the IRT reacted immunologically with anti-IRT monoclonal antibodies immobilized on a microfluidic glass chip modified with 3-aminopropyl functionalized silica nanoparticles (APSN-APTES-modified glass chips)...
October 15, 2014: Analytical Biochemistry
https://www.readbyqxmd.com/read/24908405/zinc-oxide-nanoparticles-based-microfluidic-immunosensor-applied-in-congenital-hypothyroidism-screening
#9
Marco A Seia, Sirley V Pereira, Martin A Fernández-Baldo, Irma E De Vito, Julio Raba, Germán A Messina
In this article, we present an innovative approach for congenital hypothyroidism (CHT) screening. This pathology is the most common preventable cause of mental retardation, affecting newborns around the world. Its consequences could be avoided with an early diagnosis through the thyrotropin (TSH) level measurement. To accomplish the determination of TSH, synthesized zinc oxide (ZnO) nanobeads (NBs) covered by chitosan (CH), ZnO-CH NBs, were covalently attached to the central channel of the designed microfluidic device...
July 2014: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/24758098/-methotrexate-as-inducer-of-proinflammatory-cytokines-by-epithelial-cells
#10
Alejandra Morón-Medina, Ninoska Viera, Thaís Rojas de Morales, Sirley Alcocer, Dinorath Bohorquez
Methotrexate (MTX), a drug commonly used in childhood cancer, has also been indicated as a cytotoxic agent of the oral mucosa, which can trigger the inflammatory process and increase the vascularity of epithelial tissues during the early stages of oral mucositis. The aim of this study was to determine the production of proinflammatory cytokines IL-1beta, IL-6 y TNF-alpha in epithelial cell cultures treated with MTX. Epithelial cells of human larynx, obtained from the cell line Hep-2, were cultured with different doses of MTX during different incubation times...
March 2014: Investigación Clínica
https://www.readbyqxmd.com/read/24648717/utility-values-for-glaucoma-in-brazil-and-their-correlation-with-visual-function
#11
Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Sirley Maria Freitas, Alfredo Chaoubah
PURPOSE: We sought to identify the utility values in a group of Brazilian patients with primary open-angle glaucoma (POAG), and to assess its impact on visual acuity (VA) and mean deviation index values. MATERIALS AND METHODS: This was a cross-sectional study of consecutive patients with POAG, who were interviewed using three methods for obtaining utility values: time trade-off (TTO), standard gamble anchored at risk of death (SG1), and standard gamble anchored at risk of blindness (SG2)...
2014: Clinical Ophthalmology
https://www.readbyqxmd.com/read/24564623/increased-prevalence-of-early-cochlear-damage-in-young-patients-with-type-1-diabetes-detected-by-distortion-product-otoacoustic-emissions
#12
COMPARATIVE STUDY
Carla Tomaz Botelho, Sirley Alves da Silva Carvalho, Ivani Novato Silva
OBJECTIVE: To evaluate the hearing of adolescents with diabetes mellitus type 1(DM1) by otoacoustic emissions (OAEs), and by comparing different tests with pure-tone audiometry to identify potential early cochlear impairments. DESIGN: Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAEs), and distortion product otoacoustic emissions (DPOAEs) were performed in a group of adolescents with and without DM1. Clinical characteristics, disease duration, and glycated haemoglobin levels were studied...
June 2014: International Journal of Audiology
https://www.readbyqxmd.com/read/24354243/-frequency-of-gastrointestinal-signs-and-symptoms-of-dengue-analysis-of-a-cohort-of-1484-patients
#13
Anyelo Durán, Edixon Ochoa, Sirley Alcocer, María Gómez, María Millano, Olga Martínez, Mery Maldonado, Nereida Valero
Dengue is characterized by fever, headache, arthralgia and myalgia. The presence of gastrointestinal signs and symptoms (GISS) is considered a sign of alarm in dengue; however, little information exists regarding the occurrence of these events. The aim of this study was to determine the frequency of gastrointestinal signs and symptoms in a cohort of patients with dengue. A total of 1484 medical records of patients with confirmed dengue were reviewed and classified as: dengue without warning signs (DNWS) (n = 700), dengue with warning signs (DWWS) (n = 700) and severe dengue (SD) (n = 84)...
September 2013: Investigación Clínica
https://www.readbyqxmd.com/read/23201457/dengue-nonstructural-protein-1-status-is-not-associated-to-circulating-levels-of-interleukin-17-c-reactive-protein-and-complement-in-children-with-acute-dengue
#14
Ányelo Duran, Nereida Valero, Jesús Mosquera, Héctor Pons, Mariana Torres, Sirley Alcocer, José L Castillo
BACKGROUND: During dengue infection increase in plasma level of various substances have been reported. Some of those molecules are related to the virus biology and others result of the interaction virus-host. Nonstructural protein-1 (NS1) secreted by dengue virus has been reported to have a role in dengue pathogenesis. NS1 is capable of interacting with complement to evade viral clearance. However, there is little information about the presence of serum NS1 and the levels of other molecules related to dengue pathogenesis...
March 2013: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/23152652/quality-of-life-of-glaucoma-patients-under-medical-therapy-with-different-prostaglandins
#15
Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Sirley Maria Freitas, Alfredo Chaoubah
PURPOSE: To assess the quality of life of glaucoma patients under medical therapy with different prostaglandin analogs. METHODS: A cross-sectional study of consecutive glaucoma patients was designed. We assessed the patients' quality of life through the Brazilian 25-question version of the National Eye Institute Visual Functioning Questionnaire, comprising 12 subscales (general health, general vision, ocular pain, near vision, distance vision, social function, mental health, role limitations, dependency, driving, color vision, and peripheral vision) and a total composite score...
2012: Clinical Ophthalmology
https://www.readbyqxmd.com/read/22444569/electrochemical-detection-of-a-powerful-estrogenic-endocrine-disruptor-ethinylestradiol-in-water-samples-through-bioseparation-procedure
#16
Noelia A Martínez, Sirley V Pereira, Franco A Bertolino, Rudolf J Schneider, Germán A Messina, Julio Raba
The synthetic estrogen ethinylestradiol (EE2) is an active component of oral contraceptives (OCs), considered as an endocrine disrupting compound (EDC). It is excreted from humans and released via sewage treatment plant effluents into aquatic environments. EDCs are any environmental pollutant chemical that, once incorporated into an organism, affects the hormonal balance of various species including humans. Its presence in the environment is becoming of great importance in water quality. This paper describes the development of an accurate, sensitive and selective method for capture, preconcentration and determination of EE2 present in water samples using: magnetic particles (MPs) as bioaffinity support for the capture and preconcentration of EE2 and a glassy carbon electrode modified with multi-walled carbon nanotubes (MWCNTs/GCE) as detection system...
April 20, 2012: Analytica Chimica Acta
https://www.readbyqxmd.com/read/22415564/multimorbidity-and-associated-factors-in-brazilian-women-aged-40-to-65-years-a-population-based-study
#17
Vanessa de Souza Santos Machado, Ana Lúcia Ribeiro Valadares, Lúcia Simões da Costa-Paiva, Sirley S Moraes, Aarão Mendes Pinto-Neto
OBJECTIVE: The aim of this study was to evaluate the presence of multimorbidity and associated factors in Brazilian women aged 40 to 65 years with 11 or more years of school education. METHODS: A secondary analysis of a cross-sectional population-based study was conducted using an anonymous self-report questionnaire completed by 377 women. The number of reported morbid conditions was evaluated (depression, hypertension, diabetes mellitus, urinary incontinence, and insomnia) and classified as none or one and two or more morbid conditions...
May 2012: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/22407390/quality-of-life-of-medically-versus-surgically-treated-glaucoma-patients
#18
Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Sirley Maria Freitas, Alfredo Chaoubah
PURPOSE: To assess and compare the impact of medical and surgical glaucoma treatments on patients' health-related Quality of Life (QoL). MATERIALS AND METHODS: We used the 25-question version of the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) for this cross-sectional study. Patients were divided into 3 groups: 1 (medical treatment); 2 (surgical treatment), and 3 (medical and surgical treatment). Comparisons among groups were carried out for demographic and clinical characteristics and for the NEI VFQ-25 scores...
June 2013: Journal of Glaucoma
https://www.readbyqxmd.com/read/22392245/tympanometry-with-226-and-1000-hertz-tone-probes-in-infants
#19
Luciana Macedo de Resende, Juliana Dos Santos Ferreira, Sirley Alves da Silva Carvalho, Isamara Simas Oliveira, Iara Barreto Bassi
UNLABELLED: This study aimed at describing and analyzing tympanometric results obtained with 226 Hz and 1000 Hz probe tones; checking for correlations between tympanometry, otoacoustic emissions and otoscopic examination; describing abnormal results found in the evaluation procedures. METHODS: Double-blind and prospective study. Our sample included 70 babies, between 7 days and one month and 13 days of age, without risk indicators for hearing loss, evaluated in the State Neonatal Hearing Screening Program...
February 2012: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/21984978/a-microfluidic-device-based-on-a-screen-printed-carbon-electrode-with-electrodeposited-gold-nanoparticles-for-the-detection-of-igg-anti-trypanosoma-cruzi-antibodies
#20
Sirley V Pereira, Franco A Bertolino, Martín A Fernández-Baldo, Germán A Messina, Eloy Salinas, María I Sanz, Julio Raba
In this article we report the development of an integrated microfluidic system coupled to a screen-printed carbon electrode (SPCE) applied to the quantitative determination of IgG specific antibodies present in serum samples of patients that suffer from Chagas disease. This relevant parasitic infection caused by the hemoflagellate protozoan Trypanosoma cruzi represents a major public health concern in Latin America. In order to perform the detection of mentioned antibodies, SPCE coupled to a microfluidic device was modified by electrodeposition of gold nanoparticles (AuNPs) and functionalized with Trypanosoma cruzi proteins from epimastigote membranes...
November 21, 2011: Analyst
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