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https://www.readbyqxmd.com/read/29346182/atypical-teratoid-rhabdoid-tumor-of-the-cauda-equina-in-a-child-report-of-a-very-unusual-case
#1
James M Shiflett, Betty L Herrington, David A Joyner, Ali G Saad
Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive malignant primitive neoplasms that commonly occur in children younger than 2 years of age. The prognosis is generally dismal with a median survival time of <1 year. The majority of AT/RT occur in the posterior fossa and less frequently the supratentorium. Primary pediatric spinal AT/RT are exceedingly rare and only 15 cases have been reported to date. Here we report a very unusual case of primary spinal AT/RT extensively involving the spinal cord from T11 down to the cauda equina...
January 16, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29346039/evaluation-of-a-french-regional-telemedicine-network-dedicated-to-neurological-emergencies-a-14-year-study
#2
Elisabeth Medeiros de Bustos, Eric Berthier, Didier Chavot, Benjamin Bouamra, Thierry Moulin
BACKGROUND: Equality in healthcare between urban and rural areas is problematic in France. Telemedicine networks are expected to improve equality in expertise assessment. We aimed to evaluate the use and impact of a regional rural French telemedicine network, dedicated to medical and surgical neurological emergencies, on interhospital patient transfers. METHODS: Eight community hospital emergency departments were remotely connected to the only university hospital in Franche-Comté, France...
January 18, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29345503/effectiveness-of-the-biophysical-barriers-to-the-peridural-fibrosis-in-rat-laminectomy-model
#3
Ibrahim Akkurt, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yıldıran, Mustafa Ogden, Egemen Nursoy, Elif Sari
PURPOSE: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. AIM OF THE STUDY: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP)...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29344232/novel-combination-of-paraspinal-keyhole-surgery-with-a-tubular-retractor-system-leads-to-significant-improvements-in-lumbar-intraspinal-extramedullary-schwannomas
#4
Yuandong Zhuang, Gangfeng Cai, Chaofeng Fu, Weiqiang Zhang, Wei Zhao, Rui Wang, Chunhua Wang, Songsheng Shi, Chunmei Chen
The aim of the present study was to investigate the efficacy of combining paraspinal keyhole surgery with a tubular retractor system for the microsurgical removal of lumbar intraspinal extramedullary schwannomas. A retrospective analysis was conducted of 56 patients with lumbar intraspinal extramedullary schwannomas who were treated using the microsurgical paraspinal keyhole approach with a tubular retractor system. The mean ± standard deviation was calculated for the following parameters: Surgery time (96...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29338744/new-insights-in-the-relative-radiobiological-effectiveness-of-proton-irradiation
#5
REVIEW
K Ilicic, S E Combs, T E Schmid
BACKGROUND: Proton radiotherapy is a form of charged particle therapy that is preferentially applied for the treatment of tumors positioned near to critical structures due to their physical characteristics, showing an inverted depth-dose profile. The sparing of normal tissue has additional advantages in the treatment of pediatric patients, in whom the risk of secondary cancers and late morbidity is significantly higher. Up to date, a fixed relative biological effectiveness (RBE) of 1...
January 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29336291/extent-of-surgery-in-endoscopic-transsphenoidal-skull-base-approaches-and-the-effects-on-sinonasal-morbidity
#6
Vincent Wu, Michael D Cusimano, John M Lee
BACKGROUND: Endoscopic transsphenoidal skull base surgery (ETSS) is now considered the criterion standard approach for resection of pituitary adenomas and other midline anterior skull base lesions. Normal sinonasal structures are resected during ETSS, which raises concerns for nasal morbidity and patient-based outcome. OBJECTIVE: To perform a surgical outcome assessment by examining whether the extent of ETSS approaches affected patient-specific sinonasal quality of life as measured by the 22-item Sino-Nasal Outcome Test (SNOT-22)...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29334442/a-rare-initial-presentation-of-primary-diffuse-leptomeningeal-pnet-in-a-10-year-old-male
#7
Peter Paul Lim, Jagadeesh Ramdas, Michal Ann Miller, Conrad Schuerch, George Wu
Primary leptomeningeal primitive neuroectodermal tumors (PNETs) are extremely rare childhood central nervous system malignancies harboring a very poor prognosis. There is no consensus treatment for these tumors to date. We report a case of a 10-year-old male who presented with mental status change, hydrocephalus, intracranial and spinal diffuse leptomeningeal enhancement without a primary mass upon cranial imaging and a negative initial biopsy until five months into his presentation. He responded significantly well to initial chemotherapy and radiotherapy...
December 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29331746/canadian-neurosurgery-educators-views-on-stereotactic-radiosurgery-in-residency-training
#8
Nardin Samuel, Justine Philteos, Naif M Alotaibi, Christopher Ahuja, Alireza Mansouri, Abhaya V Kulkarni
OBJECTIVE: Despite the increasing prominence of stereotactic radiosurgery (SRS) in treating intracranial and spinal pathologies, there is currently a dearth of exposure to this modality in neurosurgical residency. To address this gap, the aim of this study is to assess neurosurgery educators' views regarding the current state of SRS exposure, and to identify potential approaches to improve residency education in this domain. METHODS: Qualitative thematic analysis and constructivist grounded theory methodology were employed...
January 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#9
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29328412/therapeutic-efficacy-of-cyclosporin-a-against-spinal-cord-injury-in-rats-with-hyperglycemia
#10
Zhi-Rong Chen, Yi Ma, Hao-Hui Guo, Zhi-Dong Lu, Qun-Hua Jin
The present study aimed to explore the therapeutic effects of cyclosporin A (CsA) on spinal cord injury (SCI) in rats with hyperglycemia and to identify a novel potential method to treat SCI in the presence of hyperglycemia. Female Sprague‑Dawley (SD) rats were randomly allocated into four groups: Sham, SCI, SCI+hyperglycemia and SCI+hyperglycemia+CsA groups. Streptozotocin‑induced hyperglycemic SD rats and a weight‑drop contusion SCI model were established. The Basso, Beattie, Bresnahan scale and inclined plane test were used to evaluate the neurological function of the rats...
January 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325948/spinal-metastasis-resulting-from-atypical-thymic-carcinoid-a-case-report
#11
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29323698/xist-accelerates-neuropathic-pain-progression-through-regulation-of-mir-150-and-zeb1-in-cci-rat-models
#12
Xue-Tao Yan, Jing-Min Lu, Yu Wang, Xiao-Li Cheng, Xiang-Hu He, Wen-Zhong Zheng, Hu Chen, Yan-Lin Wang
LncRNAs are reported to participate in neuropathic pain development. LncRNA X-inactive specific transcript (XIST) is involved in the progression of various cancers. However, the role of XIST in neuropathic pain remains unclear. In our present study, we established a chronic constriction injury (CCI) rat model and XIST was found to be greatly upregulated both in the spinal cord tissues and in the isolated microglias of CCI rats. Inhibition of XIST inhibited neuropathic pain behaviors including mechanical and thermal hyperalgesia...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323045/does-vitamin-c-have-the-ability-to-augment-the-therapeutic-effect-of-bone-marrow-derived-mesenchymal-stem-cells-on-spinal-cord-injury
#13
Nesrine Salem, Mohamed Y Salem, Mohammed M Elmaghrabi, Moataz A Elawady, Mona A Elawady, Dina Sabry, Ashraf Shamaa, Abdel-Haleem H Elkasapy, Noha Ibrhim, Azza Elamir
Methylprednisolone (MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI). Vitamin C (VC) is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs), as multipotent stem cells, are promising candidates in SCI repair. To evaluate the therapeutic effects of MP, VC and BMMSCs on traumatic SCI, 80 adult male rats were randomly divided into seven groups: control, SCI (SCI induction by weight-drop method), MP (SCI induction, followed by administration of 30 mg/kg MP via the tail vein, once every other 6 hours, for five times), VC (SCI induction, followed by intraperitoneal administration of 100 mg/kg VC once a day, for 28 days), MP + VC (SCI induction, followed by administration of MP and VC as the former), BMMSCs (SCI induction, followed by injection of 3 × 106 BMMSCs at the injury site), and BMMSCs + VC (SCI induction, followed by BMMSCs injection and VC administration as the former)...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322259/csf-neurofilament-proteins-as-diagnostic-and-prognostic-biomarkers-for-amyotrophic-lateral-sclerosis
#14
Daniela Rossi, Paolo Volanti, Liliana Brambilla, Tiziana Colletti, Rossella Spataro, Vincenzo La Bella
Elevated cerebrospinal fluid (CSF), Neurofilament Light (NF-L) and phosphorylated Heavy (pNF-H) chain levels have been found in Amyotrophic Lateral Sclerosis (ALS), with studies reporting a correlation of both neurofilaments (NFs) with the disease progression. Here, we measured NF-L and pNF-H concentrations in the CSF of ALS patients from a single tertiary Center and investigated their relationship with disease-related variables. A total of 190 ALS patients (Bulbar, 29.9%; Spinal, 70.1%; M/F = 1.53) and 130 controls with mixed neurological diseases were recruited...
January 10, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29314220/histopathology-of-synovial-cysts-of-the-spine
#15
Ivan Chebib, Connie Y Chang, Joseph H Schwab, Darcy A Kerr, Vikram Deshpande, G Petur Nielsen
AIMS: Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histologic appearances. Not uncommonly, there is discrepancy between the clinico-radiologic diagnosis and histology. Therefore, we sought to characterize the histologic features of tissue submitted as "synovial cysts" of the spine. METHODS: Resected specimens of the spine labeled "synovial cysts" and "lumbar cysts" were histologically evaluated and classified based on histopathologic features...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29313091/intradural-cervical-chordoma-with-diffuse-spinal-leptomeningeal-spread-case-report-and-review-of-the-literature
#16
Jing Zhang, Chuan-Ping Gao, Xue-Jun Liu, Wen-Jian Xu
PURPOSE: Chordoma is a low-grade malignant bone tumor derived from embryonic notochord remnants along the axial skeleton. About 50% of chordomas occur in the sacral vertebrae and 35% in the skull base. Most chordomas are extradural and cause extensive bone destruction. Intradural spinal tumors without bone involvement are rare. METHODS: We herein describe the clinical features of a patient with a chordoma as well as the imaging and pathological manifestations of the tumor...
January 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29312726/is-a-clinical-target-volume-ctv-necessary-for-locally-advanced-non-small-cell-lung-cancer-treated-with-intensity-modulated-radiotherapy-a-dosimetric-evaluation-of-three-different-treatment-plans
#17
Fan Xia, Lijun Zhou, Xi Yang, Li Chu, Xiaofei Zhang, Jinjin Chu, Weigang Hu, Zhengfei Zhu
Background: The aim of this study was to determine the feasibility of omitting the clinical target volume (CTV) in patients with locally advanced non-small cell lung cancer (NSCLC) treated with intensity-modulated radiotherapy (IMRT) by comparing dosimetric characteristics of three different IMRT plans with or without CTV implementation. Methods: Thirteen patients with stage III NSCLC were reviewed. Target volumes were contoured such that the planning target volume (PTV) derived from the gross tumor volume (GTV) directly was named PTV_g and that from GTV plus CTV margin was named PTV_c...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312599/histopathological-molecular-clinical-and-radiological-characterization-of-rosette-forming-glioneuronal-tumor-in-the-central-nervous-system
#18
Chenlong Yang, Jingyi Fang, Guang Li, Shaowu Li, Tingting Ha, Jiangfei Wang, Bao Yang, Jun Yang, Yulun Xu
Objective: A rosette-forming glioneuronal tumor (RGNT) is a rare entity originally described in the fourth ventricle. Recently, RGNTs occurring in extraventricular sites and those with malignant behaviors have been reported. The purpose of this study was to analyze the clinicoradiological and histopathological features, therapeutic strategies, and outcomes of RGNTs. Methods: We enrolled 38 patients diagnosed with RGNTs pathologically between August 2009 and June 2016...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29304115/effects-of-a-self-assembling-peptide-as-a-scaffold-on-bone-formation-in-a-defect
#19
Kei Ando, Shiro Imagama, Kazuyoshi Kobayashi, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Koji Nishida, Yoshihiro Nishida, Naoki Ishiguro
Spinal fusion and bone defect after injuries, removal of bone tumors, and infections need to be repaired by implantation. In an aging society, recovery from these procedures is often difficult. In this study, we found that injection of SPG-178 leads to expression of several bone marker genes and mineralization in vitro, and revealed a significantly higher degree of newly formed bone matrix with use of SPG-178 in vivo. MC3T3-E1 cells were used to evaluate osteoblast differentiation promoted by SPG-178. To analyze gene expression, total RNA was isolated from MC3T3-E1 cells cultured for 7 and 14 days with control medium or SPG-178 medium...
2018: PloS One
https://www.readbyqxmd.com/read/29301180/virtual-preoperative-simulation-for-excision-of-spinal-tumors-surgeon-processing-of-medical-computer-assisted-design-software
#20
Jung Hwan Lee, In Ho Han, Byung Kwan Choi, Kyoung Hyup Nam, Dong Ha Kim, Chi Seung Lee
As medical computer-aided design (CAD) has improved, virtual 3-dimensional medical images have been gaining more easily without any special practice. These images can be applied to various clinical fields. This article illustrates virtual preoperative simulation for excision of spinal tumors using medical CAD software. The software was used directly by the surgeon. The process of virtual preoperative simulation for spinal tumor surgery was found to be not inordinately complicated. And, virtual simulation was helpful in determining surgical steps as well as understanding the surgical anatomy...
December 2017: Korean Journal of Spine
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