Zhao Yang, Mengran Shi, Youfeng Liang, Fuhan Zhang, Cong Li, Yinying Lu, Taian Yin, Zhaohai Wang, Yongchao Li, Mingxuan Hao, Rui Guo, Hao Yang, Guanglin Lei, Fang Sun, Yu Zhang, Zhuoya Deng, Yuying Tian, Linxiang Yu, Changqing Bai, Lei Wang, Chuanxing Wan, Haifeng Wang, Penghui Yang
BACKGROUND: Three-dimensional (3D) chromatin architecture frequently altered in cancer. However, its changes during the pathogenesis of hepatocellular carcinoma (HCC) remained elusive. METHODS: Hi-C and RNA-seq were applied to study the 3D chromatin landscapes and gene expression of HCC and ANHT. Hi-C Pro was used to generate genome-wide raw interaction matrices, which were normalized via iterative correction (ICE). Moreover, the chromosomes were divided into different compartments according to the first principal component (E1)...
November 5, 2023: Journal of Gastroenterology