keyword
https://read.qxmd.com/read/38163622/human-apoc3-overexpression-aggravates-hyperlipidemia-but-mitigates-diet-induced-coronary-atherosclerotic-disease-in-sr-bi-and-ldl-receptor-double-knockout-mice
#21
JOURNAL ARTICLE
Jiawei Liao, Yuhui Wang, Yao Wang, Jinjin Zhang, Feng Wu, George Liu, Wei Huang, Ying Zhang
No abstract text is available yet for this article.
December 30, 2023: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/38153604/identification-of-hub-genes-to-determine-drug-disease-correlation-in-breast-carcinomas
#22
JOURNAL ARTICLE
Chiranjib Bhowmick, Motiur Rahaman, Shatarupa Bhattacharya, Mandrita Mukherjee, Nishant Chakravorty, Pranab Kumar Dutta, Manjunatha Mahadevappa
The exact molecular mechanism underlying the heterogeneous drug response against breast carcinoma remains to be fully understood. It is urgently required to identify key genes that are intricately associated with varied clinical response of standard anti-cancer drugs, clinically used to treat breast cancer patients. In the present study, the utility of transcriptomic data of breast cancer patients in discerning the clinical drug response using machine learning-based approaches were evaluated. Here, a computational framework has been developed which can be used to identify key genes that can be linked with clinical drug response and progression of cancer, offering an immense opportunity to predict potential prognostic biomarkers and therapeutic targets...
December 28, 2023: Medical Oncology
https://read.qxmd.com/read/38151342/-the-role-of-apolipoprotein-c3-in-the-regulation-of-nonalcoholic-fatty-liver-disease-glucose-and-lipid-metabolism-and-islet-%C3%AE-cell-function
#23
REVIEW
Shan Yan, Zhi-Yong Ding, Yuan Gao, Wang-Jia Mao, Xiao-Yun Cheng
As a member of the apolipoprotein C (ApoC) family with a relatively high content, ApoC3 plays a major role in the regulation of triglyceride metabolism, and plays an important role in the occurrence and development of cardiovascular diseases, glucose and lipid metabolism disorders. Nonalcoholic fatty liver disease (NAFLD) refers to the accumulation of a large amount of fat in the liver in the absence of a history of chronic alcohol consumption or other damage to the liver. A large number of previous studies have shown that there is a correlation between the gene polymorphism and high expression of ApoC3 and NAFLD...
December 25, 2023: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38143756/the-analysis-of-serum-lipids-profile-in-guillain-barre-syndrome
#24
JOURNAL ARTICLE
Lijuan Wang, Yaowei Ding, Jie Liu, Guanghui Zheng, Siwen Li, Wencan Jiang, Kelin Chen, Xin Luan, Yuxin Chen, Siqi Wang, Guojun Zhang
BACKGROUND: Guillain-Barre syndrome (GBS) is an immune-mediated inflammatory peripheral neuropathy. This study aimed to conduct a systematic analysis of the serum lipids profile in GBS. METHODS: We measured the serum lipids profile in 85 GBS patients and compared it with that of 85 healthy controls matched for age and sex. Additionally, we analyzed the correlation between lipids and the severity, subtypes, precursor infections, clinical outcomes, clinical symptoms, immunotherapy, and other laboratory markers of GBS...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38127052/causal-effects-of-lipid-lowering-therapies-on-aging-related-outcomes-and-risk-of-cancers-a-drug-target-mendelian-randomization-study
#25
JOURNAL ARTICLE
Han Chen, Xinyu Tang, Wei Su, Shuo Li, Ruoyun Yang, Hong Cheng, Guoxin Zhang, Xiaoying Zhou
BACKGROUND: Despite the widespread use of statins, newer lipid-lowering drugs have been emerging. It remains unclear how the long-term use of novel lipid-lowering drugs affects the occurrence of cancers and age-related diseases. METHODS: A drug-target Mendelian randomization study was performed. Genetic variants of nine lipid-lowering drug-target genes ( HMGCR, PCKS9, NPC1L1, LDLR, APOB, CETP, LPL, APOC3 , and ANGPTL3 ) were extracted as exposures from the summary data of Global Lipids Genetics Consortium Genome-Wide Association Studies (GWAS)...
December 19, 2023: Aging
https://read.qxmd.com/read/38126174/food-intake-suppresses-apob-secretion-and-fractional-catabolic-rates-in-humans
#26
JOURNAL ARTICLE
Chunyu Zheng, Allison B Andraski, Christina Khoo, Jeremy Furtado, Frank M Sacks
BACKGROUND: Humans spend much of the day in the postprandial state. However, most research and clinical guidelines on plasma lipids pertain to blood drawn after a 12-hour fast. We aimed to study the metabolic differences of apoB lipoproteins between the fasting and postprandial states. METHODS: We investigated plasma apoB metabolism using stable isotope tracers in 12 adult volunteers under fasting and continuous postprandial conditions in a randomized crossover study...
December 21, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38108247/unraveling-potential-sex-specific-effects-of-cardiovascular-medications-on-longevity-using-mendelian-randomization
#27
JOURNAL ARTICLE
Man Ki Kwok, C Mary Schooling
BACKGROUND: Establishing the sex-specific efficacy of cardiovascular medications is pivotal to evidence-based clinical practice, potentially closing the gender gap in longevity. Trials large enough to establish sex differences are unavailable. This study evaluated sex-specific effects of commonly prescribed cardiovascular medications on lifespan. METHODS AND RESULTS: In a two-sample Mendelian randomization study, established genetic variants mimicking effects of lipid-lowering drugs, antihypertensives, and diabetes drugs were applied to genetic associations with lifespan proxied by UK Biobank maternal (n=412 937) and paternal (n=415 311) attained age...
December 18, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/38095804/inhibition-of-angiopoietin-like-protein-3-or-3-8-complex-and-apoc-iii-in-severe-hypertriglyceridemia
#28
REVIEW
Miriam Larouche, Etienne Khoury, Diane Brisson, Daniel Gaudet
PURPOSE OF REVIEW: The role of the inhibition of ANGPTL3 in severe or refractory hypercholesterolemia is well documented, less in severe hyperTG. This review focuses on the preclinical and clinical development of ApoC-III inhibitors and ANGPTL3, 4, and 3/8 complex inhibitors for the treatment of severe or refractory forms of hypertriglyceridemia to prevent cardiovascular disease or other morbidities. RECENT FINDINGS: APOC3 and ANGPTL3 became targets for drug development following the identification of naturally occurring loss of function variants in families with a favorable lipid profile and low cardiovascular risk...
December 14, 2023: Current Atherosclerosis Reports
https://read.qxmd.com/read/38085828/integrative-multianalytical-model-based-on-novel-plasma-protein-biomarkers-for-distinguishing-lung-adenocarcinoma-and-benign-pulmonary-nodules
#29
JOURNAL ARTICLE
Xue Zhang, Longtao Ji, Man Liu, Jiaqi Li, Hao Sun, Feifei Liang, Yutong Zhao, Zhi Wang, Ting Yang, Yulin Wang, Qiufang Si, Renle Du, Liping Dai, Songyun Ouyang
Given the pressing clinical problem of making a decision in diagnosis for subjects with pulmonary nodules, we aimed to discover novel plasma protein biomarkers for lung adenocarcinoma (LUAD) and benign pulmonary nodules (BPNs) and then develop an integrative multianalytical model to guide the clinical management of LUAD and BPN patients. Through label-free quantitative plasma proteomic analysis (data are available via ProteomeXchange with identifier PXD046731), 12 differentially expressed proteins (DEPs) in LUAD and BPN were screened...
December 12, 2023: Journal of Proteome Research
https://read.qxmd.com/read/38082436/genetic-insights-into-the-association-of-statin-and-newer-nonstatin-drug-target-genes-with-human-longevity-a-mendelian-randomization-analysis
#30
JOURNAL ARTICLE
Han Chen, Xiaoying Zhou, Jingwen Hu, Shuo Li, Zi Wang, Tong Zhu, Hong Cheng, Guoxin Zhang
BACKGROUND: It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between different lipid-lowering therapeutic gene targets and human longevity. METHODS: Two-sample Mendelian randomization analyses were conducted. The exposures comprised genetic variants that proxy nine drug target genes mimicking lipid-lowering effects (LDLR, HMGCR, PCKS9, NPC1L1, APOB, CETP, LPL, APOC3, and ANGPTL3)...
December 12, 2023: Lipids in Health and Disease
https://read.qxmd.com/read/38039351/exploring-apolipoprotein-c-iii-pathophysiological-and-pharmacological-relevance
#31
JOURNAL ARTICLE
Chris J Packard, Angela Pirillo, Sotirios Tsimikas, Brian A Ference, Alberico L Catapano
The availability of pharmacological approaches able to effectively reduce circulating low-density lipoprotein cholesterol (LDL-C) has led to a substantial reduction in the risk of atherosclerosis-related cardiovascular disease. However, a residual cardiovascular risk persists in treated individuals with optimal levels of LDL-C. Additional risk factors beyond LDL-C are involved and among these, elevated levels of triglycerides (TG) and triglyceride-rich lipoproteins are causally associated with an increased cardiovascular risk...
December 1, 2023: Cardiovascular Research
https://read.qxmd.com/read/38034491/lipid-lowering-drugs-affect-lung-cancer-risk-via-sphingolipid-metabolism-a-drug-target-mendelian-randomization-study
#32
JOURNAL ARTICLE
Honglin Li, Lei Zhang, Feiran Yang, Xiaoteng Feng, Rong Fu, Ruohan Zhao, Xiurong Li, Huijie Li
Background: The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear. Methods: Genome-wide association study data on low-density lipoprotein (LDL), apolipoprotein B (ApoB), and triglycerides (TG) were used to develop genetic instrumental variables (IVs) for LLDs. Two-step Mendelian randomization analyses were performed to examine the causal relationship between LLDs and lung cancer risk. The effects of ceramide, sphingosine-1-phosphate (S1P), and ceramidases on lung cancer risk were explored, and the proportions of the effects of LLDs on lung cancer risk mediated by sphingolipid metabolism were calculated...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37994343/construction-and-evaluation-of-a-novel-prognostic-risk-model-of-aging-related-genes-in-bladder-cancer
#33
JOURNAL ARTICLE
Delin Wang, Hao Ning, Haihu Wu, Yufeng Song, Yaru Chu, Feifan Liu, Zhenlin Zhao, Fei Wu, Jiaju Lyu
BACKGROUND: Bladder cancer (BLCA) is the most common malignancy of the urinary system. Muscle-invasive bladder cancer (MIBC), which constitutes approximately 25% of all BLCA cases, is characterized by frequent recurrence and early onset of metastasis. Bladder cancer most commonly occurs in elderly patients and is significantly associated with aging. However, the prognostic value of age-related genes in BLCA, especially in MIBC, remains unclear. MATERIALS AND METHODS: Training and testing sets were obtained from The Cancer Genome Atlas BLCA project...
December 2023: Current Urology
https://read.qxmd.com/read/37972731/apolipoprotein-c3-form-begets-function
#34
REVIEW
Karin E Bornfeldt
Increased circulating levels of apolipoprotein C3 (APOC3) predict cardiovascular disease (CVD) risk in humans, and APOC3 promotes atherosclerosis in mouse models. APOC3's mechanism of action is due in large part to its ability to slow the clearance of triglyceride-rich lipoproteins (TRLs) and their remnants when APOC3 is carried by these lipoproteins. However, different pools and forms of APOC3 exert distinct biological effects or associations with atherogenic processes. Thus, lipid-free APOC3 induces inflammasome activation in monocytes whereas lipid particle-bound APOC3 does not...
November 14, 2023: Journal of Lipid Research
https://read.qxmd.com/read/37925679/three-dimensional-chromatin-landscapes-in-hepatocellular-carcinoma-associated-with-hepatitis-b-virus
#35
JOURNAL ARTICLE
Zhao Yang, Mengran Shi, Youfeng Liang, Fuhan Zhang, Cong Li, Yinying Lu, Taian Yin, Zhaohai Wang, Yongchao Li, Mingxuan Hao, Rui Guo, Hao Yang, Guanglin Lei, Fang Sun, Yu Zhang, Zhuoya Deng, Yuying Tian, Linxiang Yu, Changqing Bai, Lei Wang, Chuanxing Wan, Haifeng Wang, Penghui Yang
BACKGROUND: Three-dimensional (3D) chromatin architecture frequently altered in cancer. However, its changes during the pathogenesis of hepatocellular carcinoma (HCC) remained elusive. METHODS: Hi-C and RNA-seq were applied to study the 3D chromatin landscapes and gene expression of HCC and ANHT. Hi-C Pro was used to generate genome-wide raw interaction matrices, which were normalized via iterative correction (ICE). Moreover, the chromosomes were divided into different compartments according to the first principal component (E1)...
November 5, 2023: Journal of Gastroenterology
https://read.qxmd.com/read/37902017/sp1-transcriptionally-upregulates-the-expression-of-apoc3-in-kgn-cells-to-promote-disease-progression-by-regulating-tlr2-nf-%C3%AE%C2%BAb-signalling-pathway
#36
JOURNAL ARTICLE
Na Qi, Liyang Wen, Shiyan Li, Jia Li, Cong Feng
INTRODUCTION: Apolipoprotein C3 (APOC3) is known for its important functions in metabolism-related diseases. However, the function and molecular mechanism of APOC3 in polycystic ovarian syndrome (PCOS) have not been reported. MATERIAL AND METHODS: Quantitative polymerase chain reaction and western blot assays were used to detect the expression of APOC3 in KGN cells. Small interference APOC3 (siAPOC3) was applied to reduce APOC3 expression, and the proliferation ability of human granulosa cell line (KGN cells) was measured by cell counting kit-8 and colony formation assays...
2023: Endokrynologia Polska
https://read.qxmd.com/read/37875594/gene-profiles-and-mutations-in-the-development-of-cataracts-in-the-icr-rat-model-of-hereditary-cataracts
#37
JOURNAL ARTICLE
Masaru Takashima, Kei Taniguchi, Masaya Nagaya, Shunki Yamamura, Yoshihiro Takamura, Masaru Inatani, Masaya Oki
Cataracts are opacifications of the lens that cause loss of visual acuity and ultimately of eyesight. Age-related cataract develops in most elderly people, but the mechanisms of cataract onset are incompletely understood. The Ihara Cataract Rat (ICR) is an animal model of hereditary cataracts showing cortical opacity that commonly develops prematurely. We identified putative mechanisms of cataract onset in the ICR rat model by measuring gene expression changes before and after cortical cataract development and conducting point mutation analysis...
October 24, 2023: Scientific Reports
https://read.qxmd.com/read/37866958/-association-between-apolipoprotein-c-3-sst-%C3%A2-polymorphism-and-serum-lipids-in-patients-with-gestational-diabetes-mellitus
#38
JOURNAL ARTICLE
Fangmei Tang, Huai Bai, Linbo Guan, Xinghui Liu, Ping Fan, Mi Zhou, Yujie Wu, Sixu Liu, Yufeng Wang, Dehua Li
OBJECTIVE: To investigate the apolipoprotein C-3 (APOC3) gene Sst Ⅰ polymorphism and its relationship with changes in serum lipids in patients with gestational diabetes mellitus (GDM). METHODS: A total of 630 pregnant women with GDM and 1027 normal pregnant controls were covered in the study. The genotype and allele frequencies of APOC 3 Sst Ⅰ polymorphism were analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)...
September 2023: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/37853273/apolipoprotein-c-iii-itself-stimulates-the-syk-cpla2-induced-inflammasome-activation-of-macrophage-to-boost-anti-tumor-activity-of-cd8-t-cell
#39
JOURNAL ARTICLE
Xiangyu Hu, Shizhen Ding, Guotao Lu, Zhijie Lin, Liting Liao, Weiming Xiao, Yanbing Ding, Yu Zhang, Zhengbing Wang, Weijuan Gong, Xiaoqin Jia
Increased prevalence of cancer in obese individuals is involved with dyslipidemia- induced chronic inflammation and immune suppression. Although apolipoprotein C-III (ApoC3)-transgenic mice (ApoC3TG mice) or poloxamer 407 (P407)-treated mice had hyperlipidemia, CD8+ T cells with upregulated antitumor activities were observed in ApoC3TG mice, and decreased CD8+ T cell activities were observed in P407-treated mice. Increased ApoC3 expression in hepatocellular carcinoma was associated with increased infiltration of CD8+ T cells and predicted survival...
October 18, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/37792132/updates-in-small-interfering-rna-for-the-treatment-of-dyslipidemias
#40
REVIEW
S Carugo, C R Sirtori, G Gelpi, A Corsini, L Tokgozoglu, M Ruscica
PURPOSE OF REVIEW: Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity lipid-lowering therapies. Beyond the well-known association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular prevention, the atherogenicity of lipoprotein(a) and the impact of triglyceride (TG)-rich lipoproteins cannot be overlooked...
November 2023: Current Atherosclerosis Reports
keyword
keyword
71129
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.