Kyung Jae Lee, Jin Soo Moon, Jin Gyu Lim, Homin Huh, Jeong Eun Ahn, Lia Kim, Nan Young Kim, Jae Sung Ko
BACKGROUND AND AIM: The aim of this study was to investigate the comprehensive genetic effects of exploratory variants of LYPLAL1, GCKR, HSD17B13, TRIB1, APOC3, MBOAT7, and PARVB on pediatric nonalcoholic fatty liver disease in addition to the previously reported variants of TM6SF2, PNPLA3, and SAMM50 in Korean children. METHODS: A prospective case-control study was conducted involving 309 patients diagnosed using ultrasound and 339 controls. Anthropometric measurements, liver function tests, and metabolic marker analysis were conducted, and fibrosis scores were calculated...
February 28, 2024: Journal of Gastroenterology and Hepatology