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corneal ectasia

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https://www.readbyqxmd.com/read/28937143/crab-claw-pattern-on-corneal-topography-pellucid-marginal-degeneration-or-inferior-keratoconus
#1
M Koc, K Tekin, M Inanc, P Kosekahya, P Yilmazbas
PurposeTo evaluate the topographic, tomographic, and densitometric properties of patients with pellucid marginal degeneration (PMD) and inferior keratoconus.Patients and methodsRetrospective, comparative case series. Forty-seven eyes of 32 patients with crab claw patterns were identified from 2751 patients with corneal ectasia. They were divided into two groups, inferior keratoconus and PMD, based on clinical findings. The topographic, tomographic, and densitometric measurements were analyzed.ResultsPMD was detected in 11 eyes of eight patients (mean age 50...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28932341/pathophysiology-of-keratoconus-what-do-we-know-today
#2
Uri Soiberman, James W Foster, Albert S Jun, Shukti Chakravarti
Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28932334/corneal-biomechanics-in-ectatic-diseases-refractive-surgery-implications
#3
Renato Ambrósio, Fernando Faria Correia, Bernardo Lopes, Marcella Q Salomão, Allan Luz, Daniel G Dawson, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Cynthia J Roberts
BACKGROUND: Ectasia development occurs due to a chronic corneal biomechanical decompensation or weakness, resulting in stromal thinning and corneal protrusion. This leads to corneal steepening, increase in astigmatism, and irregularity. In corneal refractive surgery, the detection of mild forms of ectasia pre-operatively is essential to avoid post-operative progressive ectasia, which also depends on the impact of the procedure on the cornea. METHOD: The advent of 3D tomography is proven as a significant advancement to further characterize corneal shape beyond front surface topography, which is still relevant...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28913504/a-review-and-meta-analysis-of-corneal-cross-linking-for-post-laser-vision-correction-ectasia
#4
REVIEW
Qi Wan, Dan Wang, HongQuan Ye, Jing Tang, Yu Han
PURPOSE: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. METHODS: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28905820/recent-advances-in-corneal-collagen-cross-linking
#5
REVIEW
Gitansha Shreyas Sachdev, Mahipal Sachdev
Corneal collagen cross-linking has become the preferred modality of treatment for corneal ectasia since its inception in late 1990s. Numerous studies have demonstrated the safety and efficacy of the conventional protocol. Our understanding of the cross-linking process is ever evolving, with its wide implications in the form of accelerated and pulsed protocols. Newer advancements in technology include various riboflavin formulations and the ability to deliver higher fluence protocols with customised irradiation patterns...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28902010/posterior-amorphous-corneal-dystrophy-associated-with-keratoglobus-a-case-report
#6
Jonathan Fay, Alexandra A Herzlich, George J Florakis
PURPOSE: Posterior amorphous corneal dystrophy (PACD) is a rare disorder characterized by sheet-like opacification of the posterior corneal stroma, corneal thinning, and decreased corneal curvature. It is not known to be associated with progressive corneal ectasia. In this report, we examine the course of a patient with PACD who developed bilateral keratoglobus-type corneal ectasia. METHODS: The clinical history of a single patient is reviewed from birth through age 15...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28900769/interface-scopulariopsis-gracilis-fungal-keratitis-following-descemet-s-stripping-automated-endothelial-keratoplasty-dsaek-with-a-contaminated-graft
#7
Craig Wilde, Marco Messina, Tara Moshiri, Susan E Snape, Senthil Maharajan
PURPOSE: To report for the first time a case of interface Scopulariopsis gracilis fungal keratitis following Descemet's stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft. METHODS: A 57-year-old man with bilateral keratoconus and previous bilateral penetrating keratoplasties (PK) developed graft failure in association with marked corneal ectasia. He underwent a successful DSAEK. Unfortunately, a contaminated graft was transplanted and the following morning we were contacted by the eye bank to inform us a slow-growing fungus had been detected in the culture plates inoculated with dextran solution used to store the issued corneoscleral button...
September 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28880339/comparison-of-corneal-dynamic-and-tomographic-analysis-in-normal-forme-fruste-keratoconic-and-keratoconic-eyes
#8
Yu Meng Wang, Tommy C Y Chan, Marco Yu, Vishal Jhanji
PURPOSE: To investigate and compare the diagnostic ability of corneal tomography and dynamic corneal response to differentiate between normal eyes and those with forme fruste keratoconus and keratoconus. METHODS: Corneal tomography was performed using Pentacam (Pentacam HR; Oculus Optikgeräte, Wetzlar, Germany). Corneal deformation response was captured via Corvis ST (Optikgeräte) using a beta version of Corvis software. Classification analysis between normal eyes and eyes with forme fruste keratoconus and between normal and keratoconic eyes was evaluated using receiver operating characteristic curves...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28876968/corneal-collagen-cross-linking-complications
#9
Charisma B Evangelista, Kathryn M Hatch
Corneal cross-linking was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in April 2016. As this approach becomes more widely used for the treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia, the medical community is becoming more familiar with potential complications associated with this procedure. This article aims to review the reported complications of collagen cross-linking for the treatment of keratoconus and post-LASIK ectasia...
September 6, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28858044/tonometry-after-intrastromal-corneal-ring-segments-for-keratoconus
#10
Paula Arribas-Pardo, Carmen Mendez-Hernandez, Ricardo Cuiña-Sardiña, José Manuel Benitez-Del-Castillo, Julian Garcia-Feijoo
SIGNIFICANCE: Reliable intraocular pressure (IOP) measurement after intrastromal corneal ring segments (ICRS) implantation is a challenge because of altered corneal morphology. In this study, IOP is measured with four tonometers, compared with Goldmann applanation tonometry (GAT) values and the influence of corneal parameters is established. PURPOSE: This study compares IOP measurements made using different tonometers in patients implanted with ICRS and assesses the effects of central corneal thickness (CCT), corneal curvature, and corneal astigmatism on the IOP measurements obtained...
August 25, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28837529/corneal-tomographic-changes-after-uv-cross-linking-for-corneal-ectasia-1-year-results
#11
Zainab Baksoellah, Itay Lavy, Lamis Baydoun, Hilde C M Hooijmaijers, Korine van Dijk, Gerrit R J Melles
PURPOSE: To evaluate changes in maximum keratometry (Kmax), corneal higher-order aberrations (HOAs), and densitometry (backscattered light) up to 1 year after UV cross-linking and their possible relation with changes in the visual outcome. METHODS: Retrospective cohort study on 18 eyes of 16 patients, who underwent UV cross-linking after the Dresden protocol for progressive keratoconus or ectasia after laser-assisted in situ keratomileusis. Corrected distance visual acuity (CDVA), Scheimpflug-based corneal tomography, mean image brightness (corneal densitometry) from the anterior 120 μm of the midcornea, and posterior 60 μm of the central 6 mm of the cornea, and HOAs were evaluated...
August 23, 2017: Cornea
https://www.readbyqxmd.com/read/28815089/risk-assessment-for-corneal-ectasia-following-photorefractive-keratectomy
#12
Nir Sorkin, Igor Kaiserman, Yuval Domniz, Tzahi Sela, Gur Munzer, David Varssano
PURPOSE: To analyze the risk factors associated with a series of ectasia cases following photorefractive keratectomy (PRK) and all published cases. METHODS: In a retrospective study on post-PRK ectasia patients, 9 eyes of 7 patients were included, in addition to 20 eyes of 13 patients from the literature. Risk of post-PRK ectasia was calculated using the ectasia risk score system (ERSS) for laser in situ keratomileusis (LASIK) patients. The percent tissue altered (PTA) was also evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28799822/corneal-ectasia-in-a-boy-with-homozygous-kera-mutation
#13
Arif O Khan
No abstract text is available yet for this article.
August 11, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28777776/immunologic-rejection-episodes-after-deep-anterior-lamellar-keratoplasty-incidence-and-risk-factors
#14
Andres Gonzalez, Marianne O Price, Matthew T Feng, Christopher Lee, Juan G Arbelaez, Francis W Price
PURPOSE: To assess the rejection episode rate after deep anterior lamellar keratoplasty (DALK) and to identify associated risk factors. METHODS: This retrospective review of 251 primary DALK procedures performed by 14 surgeons at a single center between February 2008 and November 2015 evaluated the rejection episode rate and associated risk factors using Kaplan-Meier survival and proportional hazards analyses, which took the length of follow-up into consideration...
September 2017: Cornea
https://www.readbyqxmd.com/read/28749897/role-of-scleral-contact-lenses-in-management-of-coexisting-keratoconus-and-stevens-johnson-syndrome
#15
Varsha M Rathi, Mukesh Taneja, Srikanth Dumpati, Preeji S Mandathara, Virender S Sangwan
PURPOSE: To report the rare coexistence of keratoconus and Stevens-Johnson syndrome (SJS) managed with scleral contact lenses (ScCLs). METHODS: This is a retrospective case series. Five patients (9 eyes) who had coexisting SJS and corneal ectasia were identified from the database during the 2-year period. Diagnosis of SJS was based on a positive history of drug reactions, signs of ocular surface disease, and the presence of keratinization of lid margins. Keratoconus was diagnosed by slit-lamp biomicroscopy...
October 2017: Cornea
https://www.readbyqxmd.com/read/28745658/-results-of-corneal-crosslinking-for-pellucid-marginal-corneal-degeneration
#16
M M Bikbov, V K Surkova, A R Khalimov, E L Usubov
AIM: to evaluate the clinical effectiveness of crosslinking in patients with progressive pellucid marginal corneal degeneration (PMCD). MATERIAL AND METHODS: A total of 9 patients (16 eyes) with progressive PMCD were treated by standard crosslinking. The cornea was saturated with Dextralink solution and UV-A irradiated at 3 mW/cm2 for 30 minutes. The follow-up period was 12 months. RESULTS: One month after treatment, there was a slight decrease in uncorrected and best corrected visual acuity (UCVA and BCVA) - from 0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28726533/ophthalmic-findings-in-patients-with-arterial-tortuosity-syndrome-and-carriers-a-case-series
#17
Joshua S Hardin, Yuri A Zarate, Bert Callewaert, Paul H Phillips, David B Warner
INTRODUCTION: Arterial tortuosity syndrome (ATS) is a rare autosomal recessive disease hallmarked by tortuosity, stenosis, and aneurysm development of large- and medium-sized arteries. Mutations in SLC2A10, a gene that encodes the facilitative glucose transporter GLUT10, cause ATS. Several case reports have noted associated ophthalmic findings such as keratoconus, keratoglobus, and myopia without detailed descriptions or standardized examinations. We report the ophthalmic findings in a cohort of compound heterozygous ATS patients and heterozygous carriers of SLC2A10 mutations...
July 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28700139/oct-layered-tomography-of-the-cornea-provides-new-insights-on-remodeling-after-photorefractive-keratectomy
#18
Rachana S Chandapura, Rohit Shetty, Rushad Shroff, Neha Shilpy, Mathew Francis, Abhijit Sinha Roy
OCT (optical coherence tomography) of corneal layers was generated to analyze the remodeling of the epithelium and stroma after photorefractive keratectomy (PRK). Myopic PRK was performed in 15 patients. One eye underwent manual scraping of epithelium while the other was treated with Epi clear. Epi clear allowed a gentler removal of the epithelium compared to manual scraping. Scheimpflug (Pentacam, OCULUS Optikgerate Gmbh, Wetzlar, Germany) and OCT (RTVue, Optovue Inc., Fremont, California, USA) scans of the cornea were performed before and after PRK (3 months)...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28683485/-therapeutic-options-in-keratoconus
#19
Frederik Raiskup, Janine Lenk, Robert Herber, Zisis Gatzioufas, Eberhard Spörl
A recent epidemiology study revealed that prevalence of keratoconus was much higher than previously assumed. Therefore, it is no longer deemed an "orphan disease", as it has a relevant socioeconomic impact on the healthcare system. One of the most important risk factors for developing keratoconus is chronic eye rubbing which, apart from other known risk factors such as atopy or Down's syndrome, is the only modifiable factor. Informing the patient and offering behavior modifying therapies seems to be essential...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28681903/contralateral-eye-comparison-of-smile-and-flap-based-corneal-refractive-surgery-computational-analysis-of-biomechanical-impact
#20
Ibrahim Seven, Ali Vahdati, Iben Bach Pedersen, Anders Vestergaard, Jesper Hjortdal, Cynthia J Roberts, William J Dupps
PURPOSE: Computational analyses were performed to quantify and directly compare the biomechanical impact of flapless and flap-based procedures in a series of patients undergoing small incision lenticule extraction (SMILE) in one eye and flap-based femtosecond lenticule extraction in the other. METHODS: Tomographic data from 10 eyes of 5 patients undergoing femtosecond laser refractive lenticule extraction for myopic astigmatism with or without a stromal flap (femtosecond lenticule extraction in one eye, SMILE in the contralateral eye) were used to generate computational models...
July 1, 2017: Journal of Refractive Surgery
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