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corneal ectasia

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https://www.readbyqxmd.com/read/28594648/risk-profiles-of-ectasia-after-keratorefractive-surgery
#1
Pushpanjali Giri, Dimitri T Azar
PURPOSE OF REVIEW: To identify and evaluate the risk factors of iatrogenic ectasia after refractive surgery. RECENT FINDINGS: We reviewed recently published papers that identified various risk factors associated with ectasia after LASIK, photorefractive keratectomy, small incision lenticule extraction, and other refractive surgical procedures. We also attempted to evaluate the relative contributions of these factors to the development of ectasia following refractive surgery...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28576215/effect-of-dry-eye-on-scheimpflug-imaging-of-the-cornea-and-elevation-data
#2
Leyla Asena, Dilek D Altınörs, Şefik Cezairlioğlu, Sefer Ogün Bölük
OBJECTIVE: To evaluate the effect of dry eye on Scheimpflug imaging of the cornea and elevation data. DESIGN: Prospective observational study. PARTICIPANTS: Scheimpflug images of 50 patients with dry eye who were being tested for eligibility for corneal refractive surgery were screened. Twelve eyes of 12 patients with abnormal Belin/Ambrosio enhanced ectasia display (BAD) anterior elevation difference were included in the study. The patients had no history of contact lens wear or any other sign of ectasia...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28559422/comparison-of-corneal-dynamic-parameters-and-tomographic-measurements-using-scheimpflug-imaging-in-keratoconus
#3
Tommy Cy Chan, Yu Meng Wang, Marco Yu, Vishal Jhanji
AIM: To compare the diagnostic ability of corneal tomography and corneal dynamic response measurements in normal and keratoconus eyes. METHODS: Consecutive patients with grade II-III keratoconus and age-matched normal subjects were recruited. Corneal imaging was performed using Pentacam (Oculus Optikgeräte, Wetzlar, Germany) and Corvis (Oculus Optikgeräte). A beta version of Corvis software was used with three additional parameters: maximal change of arc length, deformation amplitude (DA) ratio 1 and DA ratio 2...
May 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495906/emergency-corneal-grafting-in-the-uk-a-6-year-analysis-of-the-uk-transplant-registry
#4
Parwez Hossain, Abdo Karim Tourkmani, Dimitri Kazakos, Mark Jones, David Anderson
BACKGROUND: Corneal graft (CG) surgery is the most common and successful tissue transplant worldwide. A small and important group of patients are operated in emergency situations, typically to save a perforated eye. Our knowledge of the indications and outcomes of emergency corneal graft (eCG) is limited. METHODS: Retrospective, multifactorial analysis of all CGs registered by the UK Transplant Service from April 1999 to March 2005. RESULTS: A total of 12 976 CGs were performed...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28470657/-morphologic-corneal-changes-after-crosslinking-for-keratoconus
#5
P L Müller, K U Löffler, M Kohlhaas, F G Holz, M C Herwig-Carl
Keratoconus is a relatively common (1 : 2000) bilateral disease leading to a change in biochemical and biomechanical corneal structure as well as thinning and ectasia. For more than 10 years, crosslinking has been a therapeutic option in cases of progression. Using riboflavin and UVA-radiation, the anterior corneal stroma (300 µm) gets stiffened by crosslinking of collagen fibers. When protocols and limitations are adhered, the procedure is described to be effective and of low-risk. This review gives an overview about physiologic and pathologic changes in keratoconic corneas before and after crosslinking...
May 3, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28450380/in-vivo-confocal-microscopy-and-tear-cytokine-analysis-in-post-lasik-ectasia
#6
Natasha Kishore Pahuja, Rohit Shetty, Rashmi Deshmukh, Anupam Sharma, Rudy M M A Nuijts, Vishal Jhanji, Swaminathan Sethu, Arkasubhra Ghosh
AIM: Corneal keratectasia is one of the complications associated with laser in situ keratomileusis (LASIK) that results in vision impairment. The pathogenesis of post-LASIK ectasia (PLE) remains underexplored. We report the tear cytokine profile and in vivo confocal microscopy (IVCM) findings in eyes with PLE. METHODS: This retrospective study included age-matched 7 (14 eyes) post-LASIK controls (PLCs) and 6 (12 eyes) PLE subjects. Corneal topography was used to categorise the subjects into PLC and PLE groups...
April 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28435217/patient-selection-for-corneal-collagen-cross-linking-an-updated-review
#7
REVIEW
Virgilio Galvis, Alejandro Tello, Alvaro I Ortiz, Luis C Escaf
Corneal cross-linking (CXL) is an option that in the last decade has demonstrated its efficacy and safety in halting the progression of keratoconus (KCN) and other corneal ectasias. Its indication has been extended beyond the classic definition that required evidence of KCN progression, especially in the presence of some risk factors for a possible progression (particularly the younger age). However, the results can be still somewhat variable today. There are several protocols, each with its own advantages and disadvantages...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28426715/acute-hypoxia-influences-collagen-and-matrix-metalloproteinase-expression-by-human-keratoconus-cells-in-vitro
#8
Tina B McKay, Jesper Hjortdal, Shrestha Priyadarsini, Dimitrios Karamichos
Keratoconus (KC) is a progressive corneal ectasia linked to thinning of the central cornea. Hard contact lenses, rigid gas permeable lenses, and scleral lenses are the primary treatment modalities for early to mid- stages of KC to correct refractive error and astigmatism that develops as a result of an irregular corneal structure. These treatments are associated with significant drawbacks, including reduced availability of the tear film and oxygen to the corneal epithelium and stroma. However, it remains unknown whether hypoxia affects corneal integrity in the KC pathobiology...
2017: PloS One
https://www.readbyqxmd.com/read/28410728/corneal-collagen-crosslinking-and-pigment-dispersion-syndrome
#9
Benjamin R LaHood, Sacha Moore
We describe the case of a keratoconus patient with pigment dispersion syndrome (PDS) who was treated for progressive corneal ectasia with corneal collagen crosslinking (CXL). Pigment dispersion syndrome has been shown to have associated morphologic changes of the corneal endothelium. Corneal CXL has the potential to cause toxicity to the corneal endothelium, and adjacent pigment might increase the likelihood of damage. In this case, the presence of PDS had no detrimental effect on the outcome of treatment, and no complications were observed at 12 months follow-up, indicating that it may be safe to perform corneal CXL in the setting of PDS...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28399067/role-of-the-corneal-epithelium-measurements-in-keratorefractive-surgery
#10
REVIEW
Marcella Q Salomão, Ana Luisa Hofling-Lima, Bernardo T Lopes, Ana Laura C Canedo, Daniel G Dawson, Rui Carneiro-Freitas, Renato Ambrósio
PURPOSE OF REVIEW: Refractive surgery has stimulated considerable progress in corneal and anterior segment imaging, and optical characterization of the eye. From front surface corneal topography, we evolved to three-dimensional corneal tomography with limbus to limbus characterization of the front and back corneal surfaces and pachymetric mapping. Corneal anatomical evaluation has further evolved to layered or segmental tomography with the ability to characterize corneal epithelial thickness profile and the elevation of stromal front surface...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28379654/corneal-collagen-crosslinking-for-post-lasik-ectasia-an-australian-study
#11
Jessica Y Tong, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John J Males
PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia...
May 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28359622/-corneal-ectasia-complicating-a-lime-burn
#12
O R Matsanga, O Lezrek, N Boutimzine, A Jait, A K Ntoutoume Rolande, M Laghmari, O Cherkaoui
No abstract text is available yet for this article.
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28355171/glaucoma-mini-shunt-implantation-after-keratoplasty
#13
Jasbeth Ledesma-Gil, María de Los Ángeles García-Rodríguez, Lulu U Gurria, Enrique O Graue-Hernández, Alejandro Navas
PURPOSE: To report the outcomes of patients who underwent miniature glaucoma shunt implantation after secondary glaucoma due to keratoplasty. MATERIALS AND METHODS: Prospective study of consecutive clinical cases who underwent mini-glaucoma shunt implantation following keratoplasty. In brief, a fornix-based conjunctival flap was performed, approximately 50% thickness scleral flap. Mitomycin C 0.025% placed under Tenon's capsule. A 25-G needle created entry for mini-shunt...
April 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28317679/distinguishing-between-contact-lens-warpage-and-ectasia-usefulness-of-optical-coherence-tomography-epithelial-thickness%C3%A2-mapping
#14
Julie M Schallhorn, Maolong Tang, Yan Li, Derek J Louie, Winston Chamberlain, David Huang
PURPOSE: To distinguish between corneal ectasia and contact lens-related warpage by characteristic patterns on corneal topography and optical coherence tomography (OCT) epithelial thickness maps. SETTING: Casey Eye Institute, Portland, Oregon, USA. DESIGN: Prospective and retrospective case series. METHODS: Axial and mean power maps were obtained on corneal topography systems. Epithelial thickness maps were generated using RTVue OCT...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317666/transepithelial-crosslinking-retreatment-of-progressive-corneal-ectasia-unresponsive-to-classic-crosslinking
#15
Roy S Rubinfeld, Rachel H Epstein, Parag A Majmudar, Deborah Kim, Michael Choi, Randy J Epstein
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28315339/elastic-microfibril-distribution-in-the-cornea-differences-between-normal-and-keratoconic-stroma
#16
Tomas L White, Philip N Lewis, Robert D Young, Koji Kitazawa, Tsutomu Inatomi, Shigeru Kinoshita, Keith M Meek
The optical and biomechanical properties of the cornea are largely governed by the collagen-rich stroma, a layer that represents approximately 90% of the total thickness. Within the stroma, the specific arrangement of superimposed lamellae provides the tissue with tensile strength, whilst the spatial arrangement of individual collagen fibrils within the lamellae confers transparency. In keratoconus, this precise stromal arrangement is lost, resulting in ectasia and visual impairment. In the normal cornea, we previously characterised the three-dimensional arrangement of an elastic fiber network spanning the posterior stroma from limbus-to-limbus...
June 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28290963/longitudinal-outcomes-of-u-s-air-force-pilot-applicants-with-waivered-astigmatism
#17
David E Andrus, Jared T Haynes, Steven T Wright
BACKGROUND: Current U.S. Air Force medical standards allow applicants to enter pilot training with up to 1.50 D of astigmatism. However, waivers are considered for individuals with up to 3.00 D of astigmatism. Although typically a benign finding, higher levels of astigmatism may be progressive and can be associated with corneal ectasia (e.g., keratoconus or pellucid marginal degeneration) leading to reduced visual acuity with spectacles and/or soft contact lenses. The goal of this study was to evaluate the long-term outcomes of pilot applicants waivered into training with astigmatism exceeding the aeromedical standard...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28251158/molecular-and-histopathological-changes-associated-with-keratoconus
#18
REVIEW
Mariam Lotfy Khaled, Inas Helwa, Michelle Drewry, Mutsa Seremwe, Amy Estes, Yutao Liu
Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal transplantation in the Western countries. KC usually starts at puberty and progresses until the third or fourth decade; however its progression differs among patients. In the keratoconic cornea, all layers except the endothelium have been shown to have histopathological structural changes. Despite numerous studies in the last several decades, the mechanisms of KC development and progression remain unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28251095/post-photorefractive-keratectomy-corneal-ectasia
#19
Anna M Roszkowska, Margherita S Sommario, Mario Urso, Pasquale Aragona
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#20
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
April 2017: Klinische Monatsblätter Für Augenheilkunde
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