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corneal ectasia

Amani E Badawi
PURPOSE: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia. DESIGN: This study is a prospective nonrandomized controlled study. SETTING: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt. METHODS: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm(2) for 9 minutes)...
2016: Clinical Ophthalmology
Katherine Lun, Manotosh Ray
PURPOSE: To report a case of keratectasis of a patient underwent INTRACOR presbyopic treatment 5 years ago. METHODS: Case Report. RESULTS: Fifty-eight-year-old gentleman had presented with deteriorating vision in his left eye. He reported undergoing INTRACOR presbyopic treatment in that eye 5 years ago. At presentation, his best-corrected visual acuity was 20/40. Slit-lamp examination of the left eye showed an ectatic cornea with concentric corneal scars...
October 13, 2016: Eye & Contact Lens
Leopoldo Spadea, Emanuele Tonti, Enzo Maria Vingolo
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment...
2016: Clinical Ophthalmology
Ying Wu, Lei Tian, Li-Qiang Wang, Yi-Fei Huang
This was a prospective controlled clinical trial. 48 myopia patients (96 eyes) were included in this study. After LASIK, accelerated corneal collagen cross-linking (ACXL) was used for myopia treatment. During 6-month follow-up, the results of LASIK-ACXL treatment were studied and compared to the LASIK-only procedure. The results showed that no statistically significant differences in UDVA, CDVA, MRSE, K mean, pachymetry, or ECD were found between the two groups at the visit after 6 months of follow-up (all P > 0...
2016: BioMed Research International
William Joseph Dupps, Ibrahim Seven
PURPOSE: To investigate biomechanical strain as a structural susceptibility metric for corneal ectasia in a large-scale computational trial. METHODS: A finite element modeling study was performed using retrospective Scheimpflug tomography data from 40 eyes of 40 patients. LASIK and PRK were simulated with varied myopic ablation profiles and flap thickness parameters across eyes from LASIK candidates, patients disqualified for LASIK, subjects with atypical topography, and keratoconus subjects in 280 simulations...
August 2016: Transactions of the American Ophthalmological Society
Lia Florim Patrão, Ana Laura Caiado Canedo, João Luiz Peixoto Braga de Azevedo, Rosane Correa, Renato Ambrósio
We report two cases of suspicious asymmetric bow tie and inferior steepening on topographic evaluations with reflection (Placido) and projection (Scheimpflug). Rotating Scheimpflug corneal and anterior segment tomography (Oculus Pentacam HR, Wetzlar, Germany)® was performed in the first case, with a maximal keratometric value (Kmax) of 43.2 D and an overall deviation value from the Belin/Ambrósio Enhanced Ectasia Display (BAD-D) of 1.76, which was observed in the study eye (OD). BAD-D was 6.59 in the fellow eye, which had clinical findings that were consistent with keratoconus stage 2...
July 2016: Arquivos Brasileiros de Oftalmologia
Mohammadali Hasani, Hassan Hashemi, Ebrahim Jafarzadehpur, Abbas Ali Yekta, Nooshin Dadbin, Mehdi Khabazkhoob
PURPOSE: To estimate the fitting parameters of the hybrid contact lens in patients with corneal ectasia using the rigid gas permeable (RGP) lens. METHODS: Thirty-four eyes with corneal ectasia were evaluated in this study. The patients were examined once with the RGP lens and once with the hybrid contact lens. The relationship between the base curvature of the RGP and the vault of the hybrid lens and the correlation between their powers were analyzed. RESULTS: We found a linear relationship between the base curvature of the RGP lens and the vault of the hybrid lens (P < 0...
September 2016: Journal of Current Ophthalmology
Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Christian Jonescu-Cuypers, Cristina Nicula, Dana Dascalescu, Miruna Cristea, Liliana-Mary Voinea
Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus...
2016: Disease Markers
Solon Thanos, Patrick Oellers, Melissa Meyer Zu Hörste, Verena Prokosch, Stefan Schlatt, Berthold Seitz, Zisis Gatzioufas
PURPOSE: Keratoconus (KC) is a corneal ectasia whose pathophysiology is still mostly unknown. We investigated whether thyroid gland dysfunction (TGD) is associated with the development of KC. METHODS: We first conducted an epidemiological study, examining the prevalence of TGD among patients with KC. Then, we compared tear thyroxine (T4) in TGD and immunohistochemical staining of its receptors (T4Rs) between patients with KC and controls. The significance of T4 for corneal metabolism was studied in organotypic tissue cultures from monkey corneas...
October 2016: Cornea
Natasha Pahuja, Rushad Shroff, Pratik Pahanpate, Mathew Francis, Leio Veeboy, Rohit Shetty, Rudy M M A Nuijts, Abhijit Sinha Roy
Irregularity of the Bowman's layer (BL) in keratoconus (KC, sample size (n) = 28) and forme fruste keratoconus (FFKC, n = 18) eyes was evaluated. Subjects underwent high resolution OCT imaging (Bioptigen Inc., USA) and corneal tomography (Pentacam v1.20r41, OCULUS Optikgeräte GmbH, Germany). Anterior edge of the BL was segmented. A Bowman's roughness index (BRI) was defined as the sum of the enclosed areas between segmented edge and a smooth 3(rd) order polynomial fit to the edge. BRI was compared with corneal aberrations, Keratoconus percentage index (KISA), Cone location magnitude index (CLMI) and Belin-Ambrosio enhanced ectasia display overall deviation index (BAD-D)...
August 24, 2016: Journal of Biophotonics
Paolo Vinciguerra, Vito Romano, Pietro Rosetta, Emanuela F Legrottaglie, Magdalena Kubrak-Kisza, Claudio Azzolini, Riccardo Vinciguerra
Purpose. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL). Methods. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity (BSCVA), sphere and cylinder refraction, corneal topography, Scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT), and endothelial cell count were assessed at baseline and at 1, 3, and 6 months of follow-up...
2016: BioMed Research International
Zhe Xu, Jun Jiang, Chun Yang, Shenghai Huang, Mei Peng, Weibo Li, Lele Cui, Jianhua Wang, Fan Lu, Meixiao Shen
Ultra-high resolution optical coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement the thicknesses. The purpose of this study was to validate the diagnostic power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT in the diagnosis of sub-clinical keratoconus (KC). Each eye of 37 KC patients, asymptomatic fellow eyes of 32 KC patients, and each eye of 81 normal subjects were enrolled. Vertical thickness profiles of the corneal epithelium and Bowman's layer were measured by UHR-OCT...
2016: Scientific Reports
Alain Saad, Damien Gatinel
PURPOSE: To evaluate the accuracy of a new objective method based on Placido disk-derived data for the detection of eyes at risk of ectasia. METHODS: One hundred nineteen eyes of 176 patients were included and separated into two groups, normal and forme fruste keratoconus (FFKC), using automated corneal classification software. Normal eyes (n = 114) were classified as negative for keratoconus and keratoconus suspect and had undergone LASIK with unremarkable follow-up for 4 years...
August 1, 2016: Journal of Refractive Surgery
Milorad Milivojević, Vladimir Petrović, Miroslav Vukosavljević, Ivan Marjanović, Mirko Resan
BACKGROUND/AIM: Enlargement of optical zone (OZ) diameter during laser in situ keratomileusis (LASIK) correction of myopia postoperatively improves the optical outcome, however, it also leads to the increased stroma tissue consumption--progressive corneal thinning. The aim of this investigation was to present the possibility of safe OZ enlargement without impairing the structural stability of the cornea, while obtaining an improved optical outcome with LASIK treatment of short-sightedness...
June 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Marcel Y Avila, Mauricio Narvaez, Juan P Castañeda
PURPOSE: To evaluate the effect of genipin, a natural crosslinking agent, in rabbit eyes. SETTING: Department of Ophthalmology, Universidad Nacional de Colombia Centro de Tecnologia Oftalmica, Bogotá, Colombia. DESIGN: Experimental study. METHODS: Ex vivo rabbit eyes (16; 8 rabbits) were treated with genipin 1.00%, 0.50%, and 0.25% for 5 minutes with a vacuum device to increase corneal permeability. Penetration was evaluated using Scheimpflug pachymetry (Pentacam)...
July 2016: Journal of Cataract and Refractive Surgery
Albert Y Cheung, David G Heidemann
PURPOSE: To report a case of globe rupture in a patient with post-laser in situ keratomileusis (LASIK) ectasia after blunt trauma. METHODS: Observational case report. RESULTS: A 42-year-old man with a history of post-LASIK ectasia sustained paracentral corneal rupture secondary to blunt trauma from a fist to his left eye (OS). Slit-lamp examination revealed rupture in the posterior stroma (inferior paracentral) of the OS with an overlying intact LASIK flap; however, the inferior edges of the LASIK flap were Seidel positive...
July 27, 2016: Cornea
Sophia Z Mian, Joshua S Agranat, Deborah S Jacobs
OBJECTIVES: To report experience with Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment for complications after laser in situ keratomileuisis (LASIK). METHODS: Retrospective review of clinical and manufacturing records. A database of patients who underwent PROSE treatment from 1992 to 2007 was searched to yield all patients with history of LASIK. Primary indication for PROSE treatment and year of LASIK is reported as well as history of contact lens intolerance and pretreatment and posttreatment best-corrected visual acuity (BCVA)...
July 27, 2016: Eye & Contact Lens
D P S O'Brart
Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A (UVA) radiation is the first therapeutic modality that appears to arrest the progression of keratoconus and other corneal ectasias. Riboflavin is central to the process, acting as a photosensitizer for the production of oxygen singlets and riboflavin triplets. These free radicals drive the CXL process within the proteins of the corneal stroma, altering its biomechanical properties. Riboflavin also absorbs the majority of the UVA radiation, which is potentially cytotoxic and mutagenic, within the anterior stroma, preventing damage to internal ocular structures, such as the corneal endothelium, lens and retina...
June 2016: Drugs of Today
Jaakko S Mattila, Juha M Holopainen
PURPOSE: To describe a case of bilateral ectasia after small incision lenticule extraction (SMILE) in a patient with early keratoconus. METHODS: Case report. RESULTS: Bilateral SMILE was performed on a patient even though preoperative topographies showed changes indicating early keratoconus. The right eye underwent further photorefractive keratectomy enhancement 18 months later. The patient developed a bilateral corneal ectasia. CONCLUSIONS: This case underlines the importance of thorough preoperative assessment for possible keratoconus suspect changes with corneal topography to avoid postoperative ectasia...
July 1, 2016: Journal of Refractive Surgery
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