keyword
https://read.qxmd.com/read/38146608/are-the-width-length-depth-and-area-of-submucosal-invasion-predictive-of-lymph-node-metastasis-in-pt1-colorectal-cancer
#21
JOURNAL ARTICLE
Olga Maynovskaia, Evgeny Rybakov, Stanislav Chernyshov, Evgeniy Khomyakov, Sergey Achkasov
PURPOSE: Submucosa-limited (pathological T1, pT1) colorectal cancers (CRCs) pose a continuing challenge in the choice of treatment options, which range from local excision to radical surgery. The aim of this study was to evaluate the morphometric and morphologic risk factors associated with regional lymph node metastasis (LNM) in pT1 CRC. METHODS: We performed a histological review of patients who underwent oncological resection between 2016 and 2022. Tumor grade, budding, poorly differentiated clusters (PDCs), cancer gland rupture, lymphovascular invasion (LVI), and presence of deep submucosal invasion (DSI), as well as width, length, total area, and area of DSI, were evaluated as potential risk factors for LNM...
December 26, 2023: Annals of Coloproctology
https://read.qxmd.com/read/38135324/association-between-the-number-of-retrieved-lymph-nodes-and-demographic-tumour-related-characteristics-in-colorectal-cancer-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Qianqian Liu, Min Huang, Jing Yang, Mengyuan Jiang, Ziru Zhao, Haitong Zhao, Tingting He, Yuping Bai, Rui Zhang, Min Zhang
OBJECTIVE: Clinical practice guidelines recommend retrieving at least 12 lymph nodes for correct staging in colorectal cancer. However, it is difficult to retrieve adequate lymph nodes because of various factors. We aimed to evaluate the association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer. DESIGN: Systematic review and meta-analysis of primary studies. DATA SOURCES: PubMed, Embase, Cochrane and Web of Science were searched from January 2016 to June 2023...
December 22, 2023: BMJ Open
https://read.qxmd.com/read/38127660/troubleshooting-tips-for-diagnosing-complex-fetal-genitourinary-malformations
#23
JOURNAL ARTICLE
April M Griffith, Paula J Woodward, Anne M Kennedy
Fetal genitourinary anomalies can present a diagnostic challenge for the radiologist. The absence of a normally located kidney may represent agenesis or be secondary to a fusion or migration abnormality. A dilated renal pelvis should prompt evaluation for a specific cause, including ureteropelvic junction obstruction, reflux, or an obstructed duplicated system. Cystic parenchymal changes are characteristic of a multicystic dysplastic kidney but may also be seen in obstructive cystic dysplasia. There are numerous causes of megacystis including chromosomal (trisomy 18 syndrome), obstruction (posterior urethral valves, urethral atresia), or muscular dysfunction (prune belly syndrome, megacystis microcolon intestinal hypoperistalsis syndrome)...
January 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/38062421/long-term-outcomes-of-single-incision-plus-one-port-laparoscopic-surgery-versus-conventional-laparoscopic-surgery-for-rectosigmoid-cancer-a-randomized-controlled-trial
#24
RANDOMIZED CONTROLLED TRIAL
Xuehua Zhang, Haitao Yuan, Zilin Tan, Gaohua Li, Zhenzhao Xu, Jinfan Zhou, Jie Fu, Mingyi Wu, Jiafei Xi, Yanan Wang
BACKGROUND: Though our previous study has demonstrated that the single-incision plus one-port laparoscopic surgery (SILS + 1) is safe and feasible for sigmoid colon and upper rectal cancer and has better short-term outcomes compared with conventional laparoscopic surgery (CLS), the long-term outcomes of SILS + 1 remains uncertain and are needed to evaluated by an RCT. METHODS: Patients with clinical stage T1-4aN0-2M0 rectosigmoid cancer were enrolled...
December 7, 2023: BMC Cancer
https://read.qxmd.com/read/38058374/indocyanine-green-guided-sentinel-lymph-node-biopsy-may-have-a-high-sensitivity-for-early-t1-t2-colon-cancer-a-prospective-study-in-indian-patients
#25
JOURNAL ARTICLE
Zeeshan Ahmed, Sanjeev M Patil, Anuradha Sekaran, Pradeep Rebala, G V Rao
OBJECTIVES: Indocyanine green (ICG) dye guided near infrared fluorescence (NIR) imaging is a promising tool for mapping lymphatics. The aim of this study was to evaluate the role of ICG guided SLN biopsy in Indian colon cancer patients. MATERIAL AND METHODS: Forty-eight patients of clinically staged T1-T3 node negative colon cancer underwent laparoscopic/open resection. Patients received colonoscopic peritumoral submucosal ICG injections for laparoscopic (n= 32) and subserosal injections for open resections (n= 16) followed by the detection of SLN using NIR camera...
September 2023: Turkish Journal of Surgery
https://read.qxmd.com/read/38040341/hypoxia-activated-glutamine-antagonist-prodrug-combined-with-combretastatin-a4-nanoparticles-for-tumor-selective-metabolic-blockade
#26
JOURNAL ARTICLE
Mengfei Zheng, Hang Xu, Yue Huang, Jiali Sun, Honglei Zhang, Zheng Lv, Zhilin Liu, Zhaohui Tang, Xuesi Chen
6-Diazo-5-oxo-L-norleucine (DON) is a potent glutamine antagonist with toxic side effects; in order to reduce these effects, multiple prodrugs have been designed. However, there are currently no reports of a DON prodrug with a defined mechanism to achieve high tumor selectivity. To improve the selective toxicity of DON to tumor cells while reducing systemic toxicity, a hypoxia-activated prodrug, termed HDON, was designed. HDON achieved remarkable tumor suppression of 76.4 ± 5.2% without leading to weight loss in an H22 murine liver cancer model with high hypoxia...
November 29, 2023: Journal of Controlled Release
https://read.qxmd.com/read/38037206/first-report-of-colletotrichum-gloeosporioides-causing-anthracnose-on-peanut-in-chongqing-china
#27
JOURNAL ARTICLE
Ying Li, Xinying Song, Kang He, Jing Yu, Manlin Xu, Zhiqing Guo, Xin Wang, Xia Zhang
In July 2022, dieback and discoloration were detected on infected stems of peanut in Qijiang District of Chongqing (106.56°E,29.41°N), China, with an incidence up to 5%. These peanut stems had disease symptoms typical of anthracnose with irregular gray-brown spots with dark brown edges, sunken, and necrotic. High temperature and high humidity were favorable for the growth of the pathogen. To isolate the pathogen, we collected 10 typical infected peanuts and cut one piece from each of symptomatic stems, surface sterilized with 0...
November 30, 2023: Plant Disease
https://read.qxmd.com/read/38023437/weighing-the-benefits-of-lymphadenectomy-in-early-stage-colorectal-cancer
#28
REVIEW
Seung Min Baik, Ryung-Ah Lee
Recent advancements in endoscopic procedures have resulted in a growing diagnosis of early colorectal cancer (CRC) cases, where classical en bloc lymph node (LN) dissection is not performed and treatment is terminated with the removal of the main cancer lesion by endoscopy without pathologic LN staging. Although many studies report noninferior outcomes of endoscopic resection in comparison to surgical resection, a cautious approach to completing treatment with endoscopic resection alone is recommended because LN metastases may be present even in early-stage CRC...
November 2023: Annals of Surgical Treatment and Research
https://read.qxmd.com/read/37997340/colonic-de-novo-clear-cell-adenocarcinoma-of-intestinal-type-a-case-report-and-review-of-the-literature
#29
JOURNAL ARTICLE
Fuyu Li, Danni Chen, Jin Chen, Ling Nie
Colorectal clear cell adenocarcinomas are rare tumors. They can be divided into two types: intestinal- and Müllerian-type. Most intestinal-type clear cell adenocarcinomas show a composite morphology, and most early-stage (T1) intestinal-type clear cell adenocarcinomas have an adenoma component. We report an additional early-stage (T1) colonic clear cell adenocarcinoma that was a de novo adenocarcinoma without any adenoma component. It had a pure morphology and the smallest size (0.6 cm) ever reported...
November 23, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/37951362/indiana-pouch-continent-cutaneous-urinary-diversion-after-robotic-assisted-radical-cystectomy-a-16-year-experience
#30
Albert H Kim, Nora H Ruel, Jonathan Yamzon, Ali-Ashgar Zhumkhawala, Clayton S Lau, Bertram E Yuh, Kevin G Chan
BACKGROUND: Population-based practice patterns in the United States reveal continent diversions are only performed in 8-10.4% of patients [1-4]. Ideally, for patients undergoing radical cystectomy the choice of urinary diversion should be influenced by clinical factors and patient preference, with discussions surrounding quality of life. Unfortunately, receipt of continent diversion has been shown to be influenced by a plethora of other factors such as surgeon preference/training, geography, socio-economic status, gender and hospital volume [1-3]...
November 9, 2023: Urology
https://read.qxmd.com/read/37941556/an-artificial-intelligence-prediction-model-outperforms-conventional-guidelines-in-predicting-lymph-node-metastasis-of-t1-colorectal-cancer
#31
JOURNAL ARTICLE
Zheng Hua Piao, Rong Ge, Lu Lu
BACKGROUND: According to guidelines, a lot of patients with T1 colorectal cancers (CRCs) undergo additional surgery with lymph node dissection after being treated by endoscopic resection (ER) despite the low incidence of lymph node metastasis (LNM). AIM: The aim of this study was to develop an artificial intelligence (AI) model to more effectively identify T1 CRCs at risk for LNM and reduce the rate of unnecessary additional surgery. METHODS: We retrospectively analyzed 651 patients with T1 CRCs...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37935373/differences-in-treatment-of-stage-i-colorectal-cancers-a-population-based-study-of-colorectal-cancers-detected-within-and-outside-of-a-screening-program
#32
JOURNAL ARTICLE
Esther Toes-Zoutendijk, Emilie C H Breekveldt, Lisa van der Schee, Iris D Nagtegaal, Marloes A G Elferink, Iris Lansdorp-Vogelaar, Leon M G Moons, Monique E van Leerdam
BACKGROUND:  Screen-detected colorectal cancers (CRCs) are often treated less invasively than stage-matched non-screen-detected CRCs, but the reasons for this are not fully understood. This study evaluated the treatment of stage I CRCs detected within and outside of the screening program in the Netherlands. METHODS : Data from the Netherlands Cancer Registry for all stage I CRCs diagnosed between January 1, 2008 and December 31, 2020 were analyzed, comparing patient, tumor, and treatment characteristics of screen-detected and non-screen-detected stage I CRCs...
January 2024: Endoscopy
https://read.qxmd.com/read/37901402/treatment-for-t1-colorectal-cancers-substratified-by-site-and-size-horses-for-courses
#33
JOURNAL ARTICLE
Kexin Shi, Zhen Yang, Kaiming Leng
BACKGROUND: Owing to advances in diagnostic technology, the diagnosis of T1 colorectal cancers (CRCs) continues to increase. However, the optimal management of T1 CRCs in the Western Hemisphere remains unclear due to limited population-based data directly comparing the efficacy of endoscopic therapy (ET) and surgical resection (SR). The purpose of this study was to report outcome data from a large Western cohort of patients who underwent ET or SR for early CRCs. METHODS: The SEER-18 database was used to identify patients with T1 CRCs diagnosed from 2004 to 2018 treated with ET or SR...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37851522/erratum-high-throughput-identification-of-resistance-to-pseudomonas-syringae-pv-tomato-in-tomato-using-seedling-flood-assay
#34
JOURNAL ARTICLE
(no author information available yet)
An erratum was issued for: High-Throughput Identification of Resistance to Pseudomonas syringae pv. Tomato in Tomato using Seedling Flood Assay. The Introduction, Protocol, Representative Results and Discussion sections were updated. The last paragraph of the Introduction section was updated from: In the seedling flood assay described in this protocol, tomato seedlings are grown on Petri dishes of sterile Murashige and Skoog (MS) media for 10 days and then are flooded with an inoculum containing the bacteria of interest and a surfactant...
October 18, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37841442/phenotypic-heterogeneity-drives-differential-disease-outcome-in-a-mouse-model-of-triple-negative-breast-cancer
#35
JOURNAL ARTICLE
Archana P Thankamony, Sonny Ramkomuth, Shikha T Ramesh, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Alexander Swarbrick, Radhika Nair
The triple negative breast cancer (TNBC) subtype is one of the most aggressive forms of breast cancer that has poor clinical outcome and is an unmet clinical challenge. Accumulating evidence suggests that intratumoral heterogeneity or the presence of phenotypically distinct cell populations within a tumor play a crucial role in chemoresistance, tumor progression and metastasis. An increased understanding of the molecular regulators of intratumoral heterogeneity is crucial to the development of effective therapeutic strategies in TNBC...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37787571/clinical-experience-of-a-smart-articulating-digital-device-for-transanal-minimally-invasive-surgery
#36
JOURNAL ARTICLE
Mohammad Faraz Khan, Emma Kearns, Ronan A Cahill
BACKGROUND: The constrained access associated with transanal minimally invasive surgery has led surgeons to deploy robotic-assisted platforms to offset inherent maneuverability limitations and, perhaps, skills deficits. IMPACT OF INNOVATION: A handheld, powered 5-mm lightweighted laparoendoscopic electromechanical digital device (HandX™, HumanXtensions, Israel) with hardware and software components that convert surgical hand movements precisely to the instrument's articulating tip enabled robotic transanal minimally invasive surgery with its full roticulation for hook diathermy and suturing...
September 25, 2023: Diseases of the Colon and Rectum
https://read.qxmd.com/read/37770605/combined-endoscopic-and-laparoscopic-surgery-cels-for-early-colon-cancer-in-high-risk-patients
#37
JOURNAL ARTICLE
Morten F S Hartwig, Mustafa Bulut, Jens Ravn-Eriksen, Lasse B Hansen, Rasmus D Bojesen, Mads Falk Klein, Henrik L Jakobsen, Morten Rasmussen, Bo Rud, Jens-Ole Eriksen, Susanne Eiholm, Anne-Marie K Fiehn, Phil Quirke, Ismail Gögenur
BACKGROUND: Local excision of early colon cancers could be an option in selected patients with high risk of complications and no sign of lymph node metastasis (LNM). The primary aim was to assess feasibility in high-risk patients with early colon cancer treated with Combined Endoscopic and Laparoscopic Surgery (CELS). METHODS: A non-randomized prospective feasibility study including 25 patients with Performance Status score ≥ 1 and/or American Society of Anesthesiologists score ≥ 3, and clinical Union of International Cancer Control stage-1 colon cancer suitable for CELS resection...
September 28, 2023: Surgical Endoscopy
https://read.qxmd.com/read/37712282/-manganese-based-nanoparticles-for-chemodynamic-therapy-of-gastrointestinal-cancer
#38
JOURNAL ARTICLE
X Lin, M Huang, J Chen, X Zhou, Z Zhong, W Lu, X Huang, T Liu
OBJECTIVE: To investigate the physicochemical features of glucose oxidase-loaded and manganese-based mesoporous silica nanoparticles (MSN@Mn-GOx) and its antitumor effect against gastrointestinal cancer. METHODS: The morphology, particle size and Fenton-like properties of MSN@Mn-GOx nanoparticles were analyzed using transmission electron microscopy (TEM), dynamic light scattering (DLS), Zeta potential analysis, ultraviolet absorption spectroscopy, energy dispersive spectroscopy and X-ray photoelectron spectroscopy...
August 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/37700171/lymph-node-metastases-and-associated-recurrence-free-survival-in-microsatellite-stable-and-unstable-colon-cancer
#39
JOURNAL ARTICLE
Lynn Hakki, Asama Khan, Mithat Gonen, Zsofia Stadler, Neil H Segal, Jinru Shia, Maria Widmar, Iris H Wei, J Joshua Smith, Emmanouil P Pappou, Garrett M Nash, Philip B Paty, Julio Garcia-Aguilar, Martin R Weiser
BACKGROUND: In contrast to microsatellite stable (MSS) colon cancer, predictors of lymph node metastases and their association with recurrence are not well-defined in microsatellite instability (MSI) colon cancer. METHODS: A cohort of nonmetastatic colon cancer patients undergoing surgery between 2015 and 2021 were evaluated for predictors of lymph node metastases (LNMs) and their association with recurrence-free survival (RFS). RESULTS: Of 1466 patients included in the analyses, 361 (25 %) had MSI...
September 12, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37669045/how-does-omitting-additional-surgery-after-local-excision-affect-the-prognostic-outcome-of-patients-with-high-risk-t1-colorectal-cancer
#40
JOURNAL ARTICLE
Akira Ouchi, Koji Komori, Tajika Masahiro, Kazuhiro Toriyama, Yoshiki Kajiwara, Shiro Oka, Yosuke Fukunaga, Kinichi Hotta, Hiroaki Ikematsu, Shunsuke Tsukamoto, Shinji Nagata, Kazutaka Yamada, Maki Konno, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro-O Matsushita, Keisuke Nakai, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Yoichi Ajioka, Kenichi Sugihara, Hideki Ueno
OBJECTIVE: To investigate how omitting additional surgery after local excision (LE) affects patient outcomes in high-risk T1 colorectal cancer (CRC). BACKGROUND: It is debatable whether additional surgery should be performed for all patients with high-risk T1 CRC regardless of the tolerability of invasive procedures. METHODS: Patients who had received LE for T1 CRC at the Japanese Society for Cancer of the Colon and Rectum institutions between 2009 and 2016 were analyzed...
February 1, 2024: Annals of Surgery
keyword
keyword
71120
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.