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https://www.readbyqxmd.com/read/27926556/natural-orifice-specimen-extraction-with-single-stapling-colorectal-anastomosis-for-laparoscopic-anterior-resection-feasibility-outcomes-and-technical-considerations
#1
Bansal Saurabh, Sheng-Chi Chang, Tao-Wei Ke, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, William Tzu-Liang Chen, Abe Fingerhut
BACKGROUND: Double and triple stapling techniques to close the rectal stump in laparoscopic anterior resection are fraught with technical drawbacks that could possibly be avoided with the use of the single stapling technique. However, little is known of its safety in laparoscopic surgery or outcomes when combined with natural orifice specimen extraction. OBJECTIVE: This study aims to analyze the feasibility and the operative and immediate postoperative outcomes of single-stapled anastomosis and natural orifice specimen extraction with conventional techniques...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27903856/laparoscopic-left-hemicolectomy-for-colon-cancer-in-peritoneal-dialysis-patients-a-valid-and-safe-surgical-technique-to-ensure-peritoneal-dialysis-survival
#2
Sara Auricchio, Giulio Mari, Andrea Galassi, Beatrice Dozio, Marco Pozzi, Dario Maggioni, Renzo Scanziani
A laparoscopic approach represents an effective alternative to open surgery in patients undergoing peritoneal dialysis (PD). In these patients, conventional thinking provides for removal of the peritoneal catheter during left colon resections because of higher risk of patient contamination and peritonitis. The present paper describes 3 cases of laparoscopic left hemicolectomy for colon cancer performed in PD patients without complications and without peritoneal catheter removal, leading to subsequent early PD resumption...
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27882569/selective-reduction-in-the-expression-of-ugts-and-sults-a-novel-mechanism-by-which-piperine-enhances-the-bioavailability-of-curcumin-in-rat
#3
Xiaohui Zeng, Dake Cai, Qiaohuang Zeng, Zhao Chen, Guoping Zhong, Juncheng Zhuo, Haining Gan, Xuejun Huang, Ziming Zhao, Nan Yao, Dane Huang, Chengzhe Zhang, Dongmei Sun, Yuxing Chen
Curcumin (CUR) is known to exert numerous health-promoting effects in pharmacological studies, but its low-bioavailability hinders the development of CUR as a feasible therapeutic agent. Piperine (PIP) has been reported to enhance the bioavailability of CUR, but the underlying mechanism remains poorly understood. In an attempt to find the mechanism by which PIP enhances the bioavailability of CUR, dosage ratio (CUR: PIP) and PIP pre-treatment are hypothesized as key factors for bioavailability improvement in this combination...
November 23, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27873495/the-effectiveness-of-ferritin-as-a-contrast-agent-for-cell-tracking-mri-in-mouse-cancer-models
#4
Chan Wha Lee, Sun Il Choi, Sang Jin Lee, Young Taek Oh, Gunwoo Park, Na Yeon Park, Kyoung Ah Yoon, Sunshin Kim, Daehong Kim, Yun Hee Kim, Jin Suck Suh
PURPOSE: We aimed to investigate the effectiveness of ferritin as a contrast agent and a potential reporter gene for tracking tumor cells or macrophages in mouse cancer models. MATERIALS AND METHODS: Adenoviral human ferritin heavy chain (Ad-hFTH) was administrated to orthotopic glioma models and subcutaneous colon cancer mouse models using U87MG and HCT116 cells, respectively. Brain MR images were acquired before and daily for up to 6 days after the intracranial injection of Ad-hFTH...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27855802/endoscopic-therapy-versus-surgery-for-t1-colon-cancer-defining-model-clinical-practice
#5
EDITORIAL
Patrick Yachimski, Chin Hur
No abstract text is available yet for this article.
December 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27820832/quantitative-multi-parametric-magnetic-resonance-imaging-of-tumor-response-to-photodynamic-therapy
#6
Tom J L Schreurs, Stefanie J Hectors, Igor Jacobs, Holger Grüll, Klaas Nicolay, Gustav J Strijkers
OBJECTIVE: The aim of this study was to characterize response to photodynamic therapy (PDT) in a mouse cancer model using a multi-parametric quantitative MRI protocol and to identify MR parameters as potential biomarkers for early assessment of treatment outcome. METHODS: CT26.WT colon carcinoma tumors were grown subcutaneously in the hind limb of BALB/c mice. Therapy consisted of intravenous injection of the photosensitizer Bremachlorin, followed by 10 min laser illumination (200 mW/cm2) of the tumor 6 h post injection...
2016: PloS One
https://www.readbyqxmd.com/read/27803903/endoscopic-ultrasound-for-staging-of-colonic-cancer-proximal-to-the-rectum-a-systematic-review-and-meta-analysis
#7
REVIEW
Marie Louise Malmstrøm, Adrian Săftoiu, Peter Vilmann, Tobias Wirenfeldt Klausen, Ismail Gögenur
BACKGROUND AND OBJECTIVES: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum. PATIENTS AND METHODS: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard...
September 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27757786/mri-can-be-used-to-assess-advanced-t-stage-colon-carcinoma-as-well-as-rectal-carcinoma
#8
Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Masahiro Yoshimura, Tomoharu Shimizu, Masaji Tani, Ryoji Kushima, Kiyoshi Murata
PURPOSE: To evaluate the feasibility of assessing advanced T-stage (T3-T4) colorectal carcinomas by correlating MRI with histopathological findings. MATERIALS AND METHODS: The study population comprised 31 patients with 32 lesions (22 colon and 10 rectal carcinomas). The relationship between the tumor and bowel layers on T2- and contrast-enhanced T1-weighted images (T2WI, CE-T1WI), bowel wall deformity, and the linear architecture of subserosal fat on T2WI scans was independently assessed by two radiologists...
December 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27756562/cyclic-non-opioid-dynorphin-a-analogues-for-the-bradykinin-receptors
#9
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Sara M Hall, Alexander Kuzmin, David Rankin, Frank Porreca, Josephine Lai, Victor J Hruby
Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that cannot be blocked by opioid antagonists. Our systematic structure-activity relationships study on Dyn A identified lead ligands 1 and 4, along with the key structural feature (i.e. amphipathicity) for the BRs. However, the ligands showed very low metabolic stability in plasma (t1/2 <1h) and therefore, in order to improve their metabolic stabilities with retained biological activities, various modifications were performed...
October 6, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27756521/the-course-of-neuropathic-symptoms-in-relation-to-adjuvant-chemotherapy-among-elderly-patients-with-stage-iii-colon-cancer-a%C3%A2-longitudinal-study
#10
Felice N van Erning, Maryska L G Janssen-Heijnen, Johannes A Wegdam, Gerrit D Slooter, Jan H Wijsman, Art Vreugenhil, Tonneke A J M Beijers, Lonneke V van de Poll-Franse, Valery E P P Lemmens
INTRODUCTION: Among the elderly, the impairment of functional capacities due to neuropathy can have a significant impact. The aim of the present study was to investigate the course of neuropathic symptoms among elderly patients with stage III colon cancer treated with CAPOX (capecitabine, oxaliplatin), capecitabine monotherapy, or no adjuvant chemotherapy. MATERIALS AND METHODS: The Netherlands Cancer Registry was used to select patients with stage III colon cancer and aged ≥ 70 years...
September 17, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27736891/gastrointestinal-dysfunction-in-patients-with-duchenne-muscular-dystrophy
#11
Christian M Lo Cascio, Oliver Goetze, Tsogyal D Latshang, Sena Bluemel, Thomas Frauenfelder, Konrad E Bloch
BACKGROUND: In adult patients with Duchenne muscular dystrophy (DMD) life-threatening constipation has been reported. Since gastrointestinal function in DMD has not been rigorously studied we investigated objective and subjective manifestations of gastrointestinal disturbances in DMD patients. METHODS: In 33 patients with DMD, age 12-41 years, eating behavior and gastrointestinal symptoms were evaluated by questionnaires. Gastric emptying half time (T1/2) and oro-cecal transit time (OCTT) were evaluated by analyzing 13CO2 exhalation curves after ingestion of 13C labeled test meals...
2016: PloS One
https://www.readbyqxmd.com/read/27636928/-multiple-primary-colorectal-cancer-clinical-aspects
#12
N V Soldatkina, O I Kit, Yu A Gevorkyan, A G Milakin
AIM: to define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). MATERIAL AND METHODS: The investigation was concerned with the data of 150 patients with T1-4N0-2M0-1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. RESULTS: Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27619237/discovery-of-stable-non-opioid-dynorphin-a-analogues-interacting-at-the-bradykinin-receptors-for-the-treatment-of-neuropathic-pain
#13
Sara M Hall, Lindsay LeBaron, Cyf Ramos-Colon, Chaoling Qu, Jennifer Yanhua Xie, Frank Porreca, Josephine Lai, Yeon Sun Lee, Victor J Hruby
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are mediated through bradykinin (BK) receptors and that intrathecal (i.th.) administration of our lead ligand 1, [des-Arg(7)]-Dyn A-(4-11), which shows good binding affinity (IC50 = 150 nM) at the BK receptors, blocks Dyn A-induced hyperalgesia in naïve animals and reverses thermal and tactile hypersensitivities in a dose-dependent manner in nerve-injured animals...
September 27, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27611610/multicenter-stratified-comparison-of-hospital-costs-between-laparoscopic-and-open-colorectal-cancer-resections-influence-of-tumor-location-and-operative-risk
#14
Johannes A Govaert, Marta Fiocco, Wouter A van Dijk, Nikki E Kolfschoten, Hubert A Prins, Jan-Willem T Dekker, Rob A E M Tollenaar, Pieter J Tanis, Michel W J M Wouters
OBJECTIVE: To compare actual 90-day hospital costs between elective open and laparoscopic colon and rectal cancer resection in a daily practice multicenter setting stratified for operative risk. BACKGROUND: Laparoscopic resection has developed as a commonly accepted surgical procedure for colorectal cancer. There are conflicting data on the influence of laparoscopy on hospital costs, without separate analyses based on operative risk. METHODS: Retrospective analyses using a population-based database (Dutch Surgical Colorectal Audit)...
September 8, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27605987/evaluation-of-changes-in-streptococcus-mutans-colonies-in-microflora-of-the-indian-population-with-fixed-orthodontics-appliances
#15
Chandresh Shukla, Raj Kumar Maurya, Vinod Singh, Manisha Tijare
BACKGROUND: Orthodontic therapy has oral ecological changes causing increased numbers of mutans streptococci in saliva and plaque. The purpose of this study was to estimate counts and colonization pattern of Streptococcus mutans after application of fixed orthodontic appliances. MATERIALS AND METHODS: Plaque samples of randomly selected sixty patients were collected before placement of orthodontic appliances from buccal and labial aspects of the anterior teeth and four first molars and readings were recorded as T0...
July 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27605431/purification-characterization-cytotoxicity-and-anticancer-activities-of-l-asparaginase-anti-colon-cancer-protein-from-the-newly-isolated-alkaliphilic-streptomyces-fradiae-neae-82
#16
Noura El-Ahmady El-Naggar, Sahar F Deraz, Hoda M Soliman, Nehal M El-Deeb, Sara M El-Ewasy
L-asparaginase is an important enzyme as therapeutic agents used in combination with other drugs in the treatment of acute lymphoblastic leukemia. A newly isolated actinomycetes strain, Streptomyces sp. NEAE-82, was potentially producing extracellular L-asparaginase, it was identified as Streptomyces fradiae NEAE-82, sequencing product was deposited in the GenBank database under accession number KJ467538. L-asparaginase was purified from the crude enzyme using ammonium sulfate precipitation, dialysis and ion exchange chromatography using DEAE Sepharose CL-6B...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27601171/small-colorectal-cancers-resembling-submucosal-tumor-with-massive-submucosal-invasion-and-lymph-node-metastasis-a-report-of-two-cases-and-review-of-the-literature
#17
Takahide Shinagawa, Soichiro Ishihara, Hiroaki Nozawa, Koji Murono, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hironori Yamaguchi, Akimasa Hayashi, Mariko Tanaka, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723)...
September 2, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27579010/evaluation-of-edible-mushroom-oudemansiella-canarii-cultivation-on-different-lignocellulosic-substrates
#18
Feng Xu, Zhiming Li, Yu Liu, Chengbo Rong, Shouxian Wang
In this study, the mycelial growth rate, mycelial colonization time, yield, and biological efficiency of the edible mushroom Oudemansiella canarii were determined, and the effects of different substrate combinations on productivity, chemical contents and amino acids were evaluated. Lignocellulosic wastes, such as cottonseed hull, sawdust, corncob, and their combinations supplemented with 18% wheat bran and 2% lime, were used for the cultivation of O. canarii. The biological efficiency (BE) and essential amino acid content of treatment T1, which consisted of 80% cottonseed hull, were the highest among all the tested treatments...
September 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27566603/laparoscopic-complete-mesocolic-excision-via-combined-medial-and-cranial-approaches-for-transverse-colon-cancer
#19
Shinichiro Mori, Yoshiaki Kita, Kenji Baba, Masayuki Yanagi, Kan Tanabe, Yasuto Uchikado, Hiroshi Kurahara, Takaaki Arigami, Yoshikazu Uenosono, Yuko Mataki, Hiroshi Okumura, Akihiro Nakajo, Kosei Maemura, Shoji Natsugoe
PURPOSE: To evaluate the safety and feasibility of laparoscopic complete mesocolic excision via combined medial and cranial approaches with three-dimensional visualization around the gastrocolic trunk and middle colic vessels for transverse colon cancer. METHODS: We evaluated prospectively collected data of 30 consecutive patients who underwent laparoscopic complete mesocolic excision between January 2010 and December 2015, 6 of whom we excluded, leaving 24 for the analysis...
August 26, 2016: Surgery Today
https://www.readbyqxmd.com/read/27558381/bacterial-colonization-of-the-peri-implant-sulcus-in-dentate-patients-a-prospective-observational-study
#20
M A Stokman, A J van Winkelhoff, A Vissink, F K L Spijkervet, G M Raghoebar
OBJECTIVES: The aim of the present study was to compare the composition of the periodontal microflora at baseline (T0) with the submucosal microflora at least 1 year after implant placement (T1) in periodontally healthy patients. MATERIAL AND METHODS: For all 169 consecutive patients that visited our clinic during 1 year, we determined their periodontal parameters, implant mucosal index, and presence of implant calculus. At T0, self-reported smoking status was recorded and subgingival and submucosal biofilm samples were obtained and analyzed for the presence and numbers of selected periodontal pathogens...
August 24, 2016: Clinical Oral Investigations
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