keyword
https://read.qxmd.com/read/38482413/construction-of-a-diagnostic-nomogram-model-for-predicting-the-risk-of-lymph-node-metastasis-in-clinical-t1-or-t2-colon-cancer-based-on-the-seer-database
#1
JOURNAL ARTICLE
Weichao Zeng, Jianhua Xu, Zhengrong Liao, Yafeng Sun
BACKGROUND: There are few methods related to predicting lymph node metastasis (LNM) in patients with clinically staged T1 or T2 colon cancer. In this study, we aimed to discover independent risk factors for patients with pathologic T-stage 1 (pT1) or pT2 colon cancer with LNM and to develop a nomogram for predicting the probability of LNM for patients with clinically staged T1 or T2 colon cancer. METHODS: All data were drawn from the Surveillance, Epidemiology, and End Results (SEER) database...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38479259/facile-synthesis-of-manganese-hafnium-nanocomposites-for-multimodal-mri-ct-imaging-and-in-vitro-photodynamic-therapy-of-colon-cancer
#2
JOURNAL ARTICLE
Mingyue Cui, Zhe Tang, Zahoor Ahmad, Chunshu Pan, Yuguang Lu, Kamran Ali, Shuqi Huang, Xiaoqing Lin, Abdul Wahab, M Zubair Iqbal, Xiangdong Kong
Precise diagnosis of complex and soft tumors is challenging, which limits appropriate treatment options to achieve desired therapeutic outcomes. However, multifunctional nano-sized contrast enhancement agents based on nanoparticles improve the diagnosis accuracy of various diseases such as cancer. Herein, a facile manganese-hafnium nanocomposites (Mn3 O4 -HfO2 NCs) system was designed for bimodal magnetic resonance imaging (MRI)/computed tomography (CT) contrast enhancement with a complimentary function of photodynamic therapy...
March 6, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38467166/isolation-and-characterization-of-a-g9p-23-porcine-rotavirus-strain-ahfy2022-in-china
#3
JOURNAL ARTICLE
Jianxin Wang, Jinzhu Zhou, Xuejiao Zhu, Xianyu Bian, Nan Han, Baochao Fan, Laqiang Gu, Xi Cheng, Sufen Li, Ran Tao, Jizong Li, Zhang Xuehan, Bin Li
Rotavirus group A (RVA) is a main pathogen causing diarrheal diseases in humans and animals. Various genotypes are prevalent in the Chinese pig herd. The genetic diversity of RVA lead to distinctly characteristics. In the present study, a porcine RVA strain, named AHFY2022, was successfully isolated from the small intestine tissue of piglets with severe diarrhea. The AHFY2022 strain was identified by cytopathic effects (CPE) observation, indirect immunofluorescence assay (IFA), electron microscopy (EM), high-throughput sequencing, and pathogenesis to piglets...
March 9, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38433058/-colorectal-cancer-with-%C3%AE-catenin-protein-expression-deficiency-a-clinicopathological-analysis
#4
JOURNAL ARTICLE
Y Y Zhang, X Xin, L Q Bi, F Y Shi, R X Cao, Y M Wang, X H Liu
Objective: To investigate the clinicopathological features and molecular characteristics of β-catenin-deficient colorectal cancer. Methods: The clinical, pathological and molecular features of 11 colorectal cancers with β-catenin protein loss diagnosed at the 960th Hospital of People's Liberation Army of China, from January 2012 to November 2022 were analyzed. Results: Among the 11 patients, 3 were males and 8 were females. Their age ranged from 43 to 74 years, with the median age of 59 years. Six were in the left colon and 5 were in the right colon...
March 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38431538/host-rnai-mediated-silencing-of-fusarium-oxysporum-f-sp-lycopersici-specific-fasciclin-like-protein-genes-provides-improved-resistance-to-fusarium-wilt-in-solanum-lycopersicum
#5
JOURNAL ARTICLE
Sambhavana Chauhan, Manchikatla Venkat Rajam
Tomato transgenics expressing dsRNA against FoFLPs act as biofungicides and result in enhanced disease resistance upon Fol infection, by downregulating the endogenous gene expression levels of FoFLPs within Fol. Fusarium oxysporum f. sp. lycopersici (Fol) hijacks plant immunity by colonizing within the host and further instigating secondary infection causing vascular wilt disease in tomato that leads to significant yield loss. Here, RNA interference (RNAi) technology was used to determine its potential in enduring resistance against Fusarium wilt in tomato...
March 3, 2024: Planta
https://read.qxmd.com/read/38423047/stereotactic-ablative-body-radiotherapy-for-primary-kidney-cancer-trog-15-03-fastrack-ii-a-non-randomised-phase-2-trial
#6
RANDOMIZED CONTROLLED TRIAL
Shankar Siva, Mathias Bressel, Mark Sidhom, Swetha Sridharan, Ben G L Vanneste, Ryan Davey, Rebecca Montgomery, Jeremy Ruben, Farshad Foroudi, Braden Higgs, Charles Lin, Avi Raman, Nicholas Hardcastle, Michael S Hofman, Richard De Abreu Lourenco, Mark Shaw, Pascal Mancuso, Daniel Moon, Lih-Ming Wong, Nathan Lawrentschuk, Simon Wood, Nicholas R Brook, Tomas Kron, Jarad Martin, David Pryor
BACKGROUND: Stereotactic ablative body radiotherapy (SABR) is a novel non-invasive alternative for patients with primary renal cell cancer who do not undergo surgical resection. The FASTRACK II clinical trial investigated the efficacy of SABR for primary renal cell cancer in a phase 2 trial. METHODS: This international, non-randomised, phase 2 study was conducted in seven centres in Australia and one centre in the Netherlands. Eligible patients aged 18 years or older had biopsy-confirmed diagnosis of primary renal cell cancer, with only a single lesion; were medically inoperable, were at high risk of complications from surgery, or declined surgery; and had an Eastern Cooperative Oncology Group performance status of 0-2...
March 2024: Lancet Oncology
https://read.qxmd.com/read/38417416/characteristics-and-prognosis-of-sporadic-neoplasias-detected-in-patients-with-ulcerative-colitis
#7
JOURNAL ARTICLE
Noriko Yamamoto, Ken Yamashita, Yudai Takehara, Shin Morimoto, Fumiaki Tanino, Yuki Kamigaichi, Hidenori Tanaka, Koji Arihiro, Fumio Shimamoto, Shiro Oka
INTRODUCTION: Patients with ulcerative colitis (UC) develop not only UC-associated neoplasias but also sporadic neoplasias (SNs). However, few studies have described the characteristics of SNs in patients with UC. Therefore, this study aimed to evaluate the clinical features and prognosis of SNs in patients with UC. METHODS: A total of 141 SNs in 59 patients with UC, detected by surveillance colonoscopy at Hiroshima University Hospital between January 1999 and December 2021, were included...
February 28, 2024: Digestion
https://read.qxmd.com/read/38408871/clinical-utility-of-laser-speckle-contrast-imaging-and-real-time-quantification-of-bowel-perfusion-in-minimally-invasive-left-sided-colorectal-resections
#8
JOURNAL ARTICLE
Garrett C Skinner, Yao Z Liu, Alan E Harzman, Syed G Husain, Alessandra C Gasior, Lisa A Cunningham, Amber L Traugott, Christopher J McCulloh, Matthew F Kalady, Peter C Kim, Emily S Huang
BACKGROUND: Left-sided colorectal surgery demonstrates high anastomotic leak rates, with tissue ischemia thought to influence outcomes. Indocyanine green is commonly used for perfusion assessment, but evidence remains mixed for whether it reduces colorectal anastomotic leaks. Laser speckle contrast imaging provides dye-free perfusion assessment in real-time through perfusion heatmaps and quantification. OBJECTIVE: This study investigates the efficacy of advanced visualization (indocyanine green versus laser speckle contrast imaging) perfusion assessment and utility of laser speckle perfusion quantification in determining ischemic margins...
February 23, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38383162/non-metastatic-colon-cancer-french-intergroup-clinical-practice-guidelines-for-diagnosis-treatments-and-follow-up-tncd-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro-achbt-sfp-afef-and-sfr
#9
Thierry Lecomte, David Tougeron, Romain Chautard, Diane Bressand, Frédéric Bibeau, Benjamin Blanc, Romain Cohen, Jérémie Jacques, Jean-Paul Lagasse, Pierre Laurent-Puig, Come Lepage, Olivier Lucidarme, Jérôme Martin-Babau, Yves Panis, Fabienne Portales, Julien Taieb, Thomas Aparicio, Olivier Bouché
INTRODUCTION: This article is a summary of the French intergroup guidelines regarding the management of non-metastatic colon cancer (CC), revised in November 2022. METHODS: These guidelines represent collaborative work of all French medical and surgical societies involved in the management of CC. Recommendations were graded in three categories (A, B, and C) according to the level of evidence found in the literature published up to November 2022. RESULTS: Initial evaluation of CC is based on clinical examination, colonoscopy, chest-abdomen-pelvis computed tomography (CT) scan, and carcinoembryonic antigen (CEA) assay...
February 20, 2024: Digestive and Liver Disease
https://read.qxmd.com/read/38345215/treatment-decision-for-locally-resected-t1-colorectal-carcinoma-verification-of-the-japanese-guideline-criteria-for-additional-surgery-based-on-long-term-clinical-outcomes
#10
JOURNAL ARTICLE
Shiro Oka, Shinji Tanaka, Yoshiki Kajiwara, Shoichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinich Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro-O Matsushita, Hiro-O Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Kenichi Sugihara, Hideki Ueno
OBJECTIVES: To verify the value of the pathological criteria for additional treatment in locally resected pT1 colorectal carcinoma (CRC) which have been used in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines since 2009. METHODS: We enrolled 4719 patients with pT1 CRC treated at 27 institutions between July 2009 and December 2016 (1259 patients with local resection alone [Group A], 1508 patients with additional surgery after local resection [Group B], and 1952 patients with surgery alone [Group C])...
February 12, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38328238/targeting-the-mswi-snf-complex-in-pou2f-pou2af-transcription-factor-driven-malignancies
#11
Tongchen He, Lanbo Xiao, Yuanyuan Qiao, Olaf Klingbeil, Eleanor Young, Xiaoli S Wu, Rahul Mannan, Somnath Mahapatra, Sanjana Eyunni, Jean Ching-Yi Tien, Xiaoju Wang, Yang Zheng, NamHoon Kim, Heng Zheng, Siyu Hou, Fengyun Su, Stephanie J Miner, Rohit Mehra, Xuhong Cao, A Chandra Sekhar, Susanta Samajdar, Murali Ramachandra, Abhijit Parolia, Christopher R Vakoc, Arul M Chinnaiyan
The POU2F3-POU2AF2/3 (OCA-T1/2) transcription factor complex is the master regulator of the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we found that the POU2F3 molecular subtype of SCLC (SCLC-P) exhibits an exquisite dependence on the activity of the mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complex. SCLC-P cell lines were sensitive to nanomolar levels of a mSWI/SNF ATPase proteolysis targeting chimera (PROTAC) degrader when compared to other molecular subtypes of SCLC...
January 25, 2024: bioRxiv
https://read.qxmd.com/read/38301928/neutrophil-hitchhiking-nanoparticles-enhance-bacteria-mediated-cancer-therapy-via-netosis-reprogramming
#12
JOURNAL ARTICLE
Yuzhen Zhao, Mingge Li, Yue Guo, Jian Jin, Fei Pei, Wenya Wang, Changhua Liu, Wenyan Yu, Jinjin Shi, Na Yin
Bacteria have shown great potential in anti-tumor treatment, and an attenuated strain of Salmonella named VNP20009 has been shown to be safe in clinical trials. However, colonized bacteria recruit neutrophils into the tumor, which release NETs to capture and eliminate bacteria, compromising bacterial-based tumor treatment. In this study, we report a neutrophil hitchhiking nanoparticles (SPPS) that block the formation of NET to enhance bacteria-mediated tumor therapy. In the 4 T1 tumor-bearing mouse model, following 24 h of bacterial therapy, there was an approximately 3...
January 30, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38275405/maternal-exposure-to-endocrine-disrupting-chemicals-analysis-of-their-impact-on-infant-gut-microbiota-composition
#13
JOURNAL ARTICLE
Mirco Vacca, Francesco Maria Calabrese, Federica Loperfido, Beatrice Maccarini, Rosa Maria Cerbo, Eduardo Sommella, Emanuela Salviati, Luana Voto, Maria De Angelis, Gabriele Ceccarelli, Ilaria Di Napoli, Benedetta Raspini, Debora Porri, Elisa Civardi, Francesca Garofoli, Pietro Campiglia, Hellas Cena, Rachele De Giuseppe
Endocrine disruptors (EDCs) are chemicals that interfere with the endocrine system. EDC exposure may contribute to the development of obesity, type 2 diabetes, and cardiovascular diseases by impacting the composition of an infant's gut microbiota during the first 1000 days of life. To explore the relationship between maternal urinary levels of Bisphenol-A and phthalates (UHPLC-MS/MS), and the composition of the infant gut microbiota (16S rDNA) at age 12 months (T3 ) and, retrospectively, at birth (T0 ), 1 month (T1 ), and 6 months (T2 ), stool samples from 20 infants breastfed at least once a day were analyzed...
January 19, 2024: Biomedicines
https://read.qxmd.com/read/38270193/distinguishing-metabolic-signals-of-liver-tumors-from-surrounding-liver-cells-using-hyperpolarized-13-c-mri-and-gadoxetate
#14
JOURNAL ARTICLE
Shubhangi Agarwal, Jeremy Gordon, Robert A Bok, Cornelius von Morze, Daniel B Vigneron, John Kurhanewicz, Michael A Ohliger
PURPOSE: To use the hepatocyte-specific gadolinium-based contrast agent gadoxetate combined with hyperpolarized (HP) [1-13 C]pyruvate MRI to selectively suppress metabolic signals from normal hepatocytes while preserving the signals arising from tumors. METHODS: Simulations were performed to determine the expected changes in HP 13 C MR signal in liver and tumor under the influence of gadoxetate. CC531 colon cancer cells were implanted into the livers of five Wag/Rij rats...
January 25, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38248975/biological-control-activities-of-rhizosphere-fungus-trichoderma-virens-t1-02-in-suppressing-flower-blight-of-flamingo-flower-anthurium-andraeanum-lind
#15
JOURNAL ARTICLE
Dusit Athinuwat, On-Uma Ruangwong, Dulanjalee L Harishchandra, Kitsada Pitija, Anurag Sunpapao
Flower blight caused by Neopestalotiopsis clavispora is an emerging disease of flamingo flower ( Anthurium andraeanum Lind.) that negatively impacts flower production. The use of rhizosphere fungi as biocontrol agents is an alternative way to control this disease instead of using synthetic fungicides. This research aimed to screen the potential of rhizosphere fungi, Trichoderma spp., with diverse antifungal abilities to control N. clavispora and to reduce flower blight in flamingo flowers. A total of ten isolates were tested against N...
January 15, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38213324/expansion-and-polarization-of-human-%C3%AE-%C3%AE-t17-cells-in-vitro-from-peripheral-blood-mononuclear-cells
#16
JOURNAL ARTICLE
Xu Chen, Xiaoling Hu, Fuxiang Chen, Jun Yan
γδ T cells play a critical role in homeostasis and diseases such as infectious diseases and tumors in both mice and humans. They can be categorized into two main functional subsets: IFN-γ-producing γδT1 cells and IL-17-producing γδT17 cells. While CD27 expression segregates these two subsets in mice, little is known about human γδT17 cell differentiation and expansion. Previous studies have identified γδT17 cells in human skin and mucosal tissues, including the oral cavity and colon...
January 5, 2024: Bio-protocol
https://read.qxmd.com/read/38191971/from-sea-to-soil-marine-bacillus-subtilis-enhancing-chickpea-production-through-in-vitro-and-in-vivo-plant-growth-promoting-traits
#17
JOURNAL ARTICLE
Khushbu Rathod, Shruti Rana, Pinakin Dhandhukia, Janki N Thakker
Various strategies are used to augment agricultural output in response to the escalating food requirements stemming from population expansion. Out of various strategies, the use of plant growth-promoting bacteria (PGPB) has shown promise as a viable technique in implementing new agricultural practices. The study of PGPB derived from rhizospheric soil is extensive, but there is a need for more exploration of marine microorganisms. The present research aims to investigate the potential of marine microorganisms as promoters of plant growth...
January 9, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38179614/dietary-intervention-with-edible-film-coated-multistrain-probiotic-lacticaseibacilli-in-nondairy-food-matrices-significantly-increased-the-recovery-of-fecal-viable-lacticaseibacilli-and-improved-the-performance-of-several-colonic-biomarkers-among-slightly-malnourished
#18
JOURNAL ARTICLE
Mosab Gad, Amr S Elbahnasawy, Asmaa A Ramadan, Gamal Abdel Naser Yamamah, Laila Hussein
Probiotic enriched dairy products are widely consumed in Western countries for their beneficial effects on the gastrointestinal tract and overall health. The present study aims to investigate the beneficial effects of probiotic Lacticaseibacilli (LAB) strains in non-dairy food matrices. A blend of edible film-coated probiotic LAB, L. plantarum , L. paracasei , and L. rhamnosus , were incorporated into plain biscuits and dry dates. Design of the randomized controlled study: Children of both sexes (mean age 55...
January 5, 2024: Food & Function
https://read.qxmd.com/read/38157110/multiple-taxa-inoculants-of-arbuscular-mycorrhizal-fungi-enhanced-colonization-frequency-biomass-production-and-water-use-efficiency-of-cassava-manihot-esculenta
#19
JOURNAL ARTICLE
Bolaji Thanni, Roel Merckx, Stefan Hauser, Adeniyi Soretire, Olivier Honnay
Increasing water use efficiency (WUE) in crops is critical to maintaining agricultural production under climate change-exacerbated drought. One of these approaches may consist of leveraging on the beneficial interactions between crops and arbuscular mycorrhizal fungi (AMF). In this study, we investigated how inoculation with AMF from three different taxa (Claroideoglomus etunicatum (T1), Gigaspora margarita (T2), and Rhizophagus irregularis (T3)) and their combination (T123) and a non-inoculated "control" treatment in a greenhouse could achieve increased biomass production and water use efficiency in cassava under three levels of water availability (100% PC, 60%-moderate stress, and 30%-severe stress)...
December 29, 2023: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38155821/patient-educational-videos-on-t1-colorectal-cancer
#20
JOURNAL ARTICLE
Nik Dekkers, Hao Dang, Jolein van der Kraan, James C H Hardwick, Alexandra M J Langers, Jurjen J Boonstra
Video 1Colorectal cancer: how does it develop and how can you detect it? Video 2A polyp suspected to be colorectal cancer: what now? Video 3Early-stage colon cancer with unfavorable features: what now?
December 2023: VideoGIE
keyword
keyword
71120
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.