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https://www.readbyqxmd.com/read/29134398/micrornas-and-their-role-for-t-stage-determination-and-lymph-node-metastasis-in-early-colon-carcinoma
#1
Melanie Rammer, Gerald Webersinke, Sophie Haitchi-Petnehazy, Eva Maier, Hubert Hackl, Pornpimol Charoentong, Theodora Malli, Maria Steinmair, Andreas L Petzer, Holger Rumpold
Worldwide, colon cancer is among the most common cancer entities. Understanding the molecular background is the key to enable accurate stage determination, which is crucial to assess optimal therapy options. The search for preoperative biomarkers is ongoing. In recent years, several studies have proposed a diagnostic and prognostic role for miRNAs in cancer. Aim of this study was to evaluate miRNA expression patterns correlating with tumor stage, especially lymph node metastasis, in primary colon carcinoma tissue...
November 13, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29133757/soluble-triggering-receptor-expressed-on-myeloid-cells-1-and-inflammatory-markers-in-colorectal-cancer-surgery-a-prospective-cohort-study
#2
Lovorka Ðerek, Dražen Servis, Adriana Unić
BACKGROUND: Major abdominal surgery, including colorectal cancer (CRC) surgery, leads to systemic inflammatory response syndrome that can be detected and monitored with inflammatory markers testing. The aims of the study were to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) in following the inflammatory response in CRC surgery and postoperative period, as well as to determine if duration of the surgery and the time that the colon has been opened during the surgery (open colon time [OCT]) reflect a larger surgical stress through inflammatory markers rise...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29118979/the-effects-of-starter-microbiota-and-the-early-life-feeding-of-medium-chain-triglycerides-on-the-gastric-transcriptome-profile-of-2-or-3-week-old-cesarean-delivered-piglets
#3
Paolo Trevisi, Davide Priori, Vincenzo Motta, Diana Luise, Alfons J M Jansman, Sietse-Jan Koopmans, Paolo Bosi
Background: The stomach is an underestimated key interface between the ingesta and the digestive system, affecting the digestion and playing an important role in several endocrine functions. The quality of starter microbiota and the early life feeding of medium chain triglycerides may affect porcine gastric maturation. Two trials (T1, T2) were carried out on 12 and 24 cesarean-delivered piglets (birth, d0), divided over two microbiota treatments, but slaughtered and sampled at two or three weeks of age, respectively...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29097918/gd-3-asparagine-anionic-linear-globular-dendrimer-second-generation-g2-complexes-novel-nanobiohybrid-theranostics
#4
Nasim Hashempour Alamdari, Mahmood Alaei-Beirami, Seyed Ataollah Sadat Shandiz, Hadi Hejazinia, Rahimeh Rasouli, Mostafa Saffari, Seyed Esmaeil Sadat Ebrahimi, Artin Assadi, Mehdi Shafiee Ardestani
Designing a unique theranostic biocompatible, biodegradable, and cost-effective agent which is easy to be synthesized as a biohybrid material was the aim of this study. In this matter, asparagine attached to anionic linear globular dendrimer G2 (as a biocompatible, biodegradable, and cost-effective agent which is negatively charged nanosized and water soluble polymer that outweighs other traditionally used dendrimers) and finally contrast agent (Gd(3+)) was loaded (which made complexes) in synthesized asparagine-dendrimer...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29068160/the-effect-of-fluoride-on-the-structure-function-and-proteome-of-intestinal-epithelia
#5
Flávia Amadeu de Oliveira, Lesley J MacVinish, Simran Amin, Duleni Herath, Pia Jeggle, Ioanna Mela, Maria Pieri, Chetanya Sharma, Gavin E Jarvis, Flávia M Levy, Mariana R Santesso, Zohaib N Khan, Aline L Leite, Rodrigo C Oliveira, Marília A R Buzalaf, J Michael Edwardson
Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we examined the effects of fluoride on the transepithelial ion transport and resistance of three intestinal epithelia. We used the Caco-2 cell line as a model of human intestinal epithelium, and rat and mouse colonic epithelia for purposes of comparison...
October 25, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29067939/a-case-of-total-laparoscopic-sigmoidectomy-involving-the-use-of-needle-forceps-and-transanal-specimen-extraction-for-sigmoid-colon-cancer
#6
Rina Takahashi, Kazuhiro Sakamoto, Hisashi Ro, Kazumasa Kure, Masaya Kawai, Shun Ishiyama, Kiichi Sugimoto, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki
A 76-year-old male underwent endoscopic mucosal resection for a stage T1 tumour of the sigmoid colon. We performed laparoscopic sigmoidectomy through 5 ports using needlescopic instruments. The resected specimen was extracted from the abdominal cavity transanally. After attaching an anvil to the sigmoidal stump, the rectal stump was reclosed using an endoscopic linear stapler, and then, colorectal anastomosis was conducted using the double stapling technique. Performing transanal specimen extraction using needlescopic forceps improves aesthetic outcomes and reduces post-operative pain and the risk of abdominal incisional hernias...
October 23, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29053818/effect-of-dietary-supplementation-of-nitrocompounds-on-salmonella-colonization-and-ileal-immune-gene-expression-in-laying-hens-challenged-with-salmonella-enteritidis
#7
Pratima Adhikari, D E Cosby, N A Cox, W K Kim
Foodborne disease caused by Salmonella Enteritidis (SE) is one of the important public health and economic concerns. A study was conducted to determine the effect of supplementation with 2-nitroethanol (NE) and 2-nitropropanol (NP) on Salmonella recovery of internal organs as well as on the immune gene expression in the ileum of laying hens. Thirty-six White Leghorns were orally gavaged with nalidixic acid resistant Salmonella Enteritidis (SENR). Hens were housed individually in wire-laying cages and randomly assigned to six dietary treatments: T1 = SENR unchallenged (negative control), T2 = SENR challenged (positive control), T3 = SENR challenged + 100 ppm NE, T4 = SENR challenged + 200 ppm NE, T5 = SENR challenged + 100 ppm NP, and T6 = SENR challenged + 200 ppm NP...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/28983781/the-distribution-of-lymph-node-metastases-and-their-size-in-colon-cancer
#8
Yusuke Yamaoka, Yusuke Kinugasa, Akio Shiomi, Tomohiro Yamaguchi, Hiroyasu Kagawa, Yushi Yamakawa, Akinobu Furutani, Shoichi Manabe
PURPOSE: The purpose of this study is to clarify the optimal extent of lymph node dissection for colon cancer by evaluating the distributions of lymph node metastases and lymph node size according to tumor location and T stage. METHODS: This study enrolled 662 patients who underwent curative resection for primary colon cancer between 2013 and 2015. Lymph node regions were classified into pericolic, intermediate, and main nodes. The short-axis diameter of each dissected lymph node was measured...
October 5, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28919031/a-pilot-study-to-assess-near-infrared-laparoscopy-with-indocyanine-green-icg-for-intraoperative-sentinel-lymph-node-mapping-in-early-colon-cancer
#9
A C Currie, A Brigic, S Thomas-Gibson, N Suzuki, M Moorghen, J T Jenkins, O D Faiz, R H Kennedy
BACKGROUND: Previous attempts at sentinel lymph node (SLN) mapping in colon cancer have been compromised by ineffective tracers and the inclusion of advanced disease. This study evaluated the feasibility of fluorescence detection of SLNs with indocyanine green (ICG) for lymphatic mapping in T1/T2 clinically staged colonic malignancy. METHODS: Consecutive patients with clinical T1/T2 stage colon cancer underwent endoscopic peritumoral submucosal injection of indocyanine green (ICG) for fluorescence detection of SLN using a near-infrared (NIR) camera...
August 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28916141/in-vivo-multimodal-tumor-imaging-and-photodynamic-therapy-with-novel-theranostic-agents-based-on-the-porphyrazine-framework-chelated-gadolinium-iii-cation
#10
Diana V Yuzhakova, Svetlana A Lermontova, Ilya S Grigoryev, Maria S Muravieva, Alena I Gavrina, Marina V Shirmanova, Irina V Balalaeva, Larisa G Klapshina, Elena V Zagaynova
BACKGROUND: A promising strategy for cancer diagnosis and therapy is the development of an agent for multimodal imaging and treatment. In the present paper we report on two novel multifunctional agents prepared on the porphyrazine pigment platform using a gadolinium (III) cation chelated by red-fluorescent tetrapyrrole macrocycles (GdPz1 and GdPz2). METHODS: Spectral and magnetic properties of the compounds were analyzed. Monitoring of GdPz1 and GdPz2 accumulation in the murine colon carcinoma CT26 was performed in vivo using fluorescence imaging and MRI...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28884768/the-composition-of-potentially-bioactive-triterpenoid-glycosides-in-red-raspberry-is-influenced-by-tissue-extraction-procedure-and-genotype
#11
Gordon J McDougall, J William Allwood, Gema Pereira-Caro, Emma M Brown, Cheryl Latimer, Gary Dobson, Derek Stewart, Nigel G Ternan, Roger Lawther, Gloria O'Connor, Ian Rowland, Alan Crozier, Chris I R Gill
The beneficial effects of consumption of berry fruits on a range of chronic diseases has been attributed (at least in part) to the presence of unique phytochemicals. Recently, we identified novel ursolic acid-based triterpenoid glycosides (TTPNs) in raspberry fruit and demonstrated their survival in human ileal fluids after feeding which confirmed their colon-availability in vivo. In this paper, in vitro digestion studies demonstrated that certain TTPNs were stable under gastrointestinal conditions and confirmed that these components may have been responsible for bioactivity noted in previous studies...
September 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28865071/promising-cellulolytic-fungi-isolates-for-rice-straw-degradation
#12
Diana Catalina Pedraza-Zapata, Andrea Melissa Sánchez-Garibello, Balkys Quevedo-Hidalgo, Nubia Moreno-Sarmiento, Ivonne Gutiérrez-Rojas
The objective of this study was to evaluate the potential of eight fungal isolates obtained from soils in rice crops for straw degradation in situ. From the initial eight isolates, Pleurotus ostreatus T1.1 and Penicillium sp. HC1 were selected for further characterization based on qualitative cellulolytic enzyme production and capacity to use rice straw as a sole carbon source. Subsequently, cellulolytic, xylanolytic, and lignolytic (Pleurotus ostreatus) activity on carboxymethyl cellulose, oat xylan, and rice straw with different nitrogen sources was evaluated...
September 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28836166/laparoscopic-complete-mesocolic-excision-via-mesofascial-separation-for-left-sided-colon-cancer
#13
Shinichiro Mori, Yoshiaki Kita, Kenji Baba, Masayuki Yanagi, Kan Tanabe, Yasuto Uchikado, Hiroshi Kurahara, Takaaki Arigami, Yoshikazu Uenosono, Yuko Mataki, Akihiro Nakajo, Kosei Maemura, Shoji Natsugoe
PURPOSE: To evaluate the safety and feasibility of laparoscopic complete mesocolic excision (CME) via mesofascial separation for left-sided colon cancer. METHODS: We evaluated prospectively collected data on 65 consecutive patients with stage I-III left-sided colon cancer, who underwent laparoscopic CME between October 2011 and September 2016. After the exclusion of 5 patients who had T4b or other active tumors, 60 patients were the subjects of this analysis. The completeness of CME, preservation of the hypogastric nerve, operative data, pathological findings, complications, and length of hospital stay were assessed...
August 23, 2017: Surgery Today
https://www.readbyqxmd.com/read/28807337/evaluation-of-cd43-expression-in-non-hematopoietic-malignancies
#14
Bjorn H Batdorf, Steven H Kroft, Paul R Hosking, Alexandra M Harrington, Alexander C Mackinnon, Horatiu Olteanu
OBJECTIVES: CD43 is normally expressed only on the surface of leukocytes, and is considered a sensitive and specific marker for hematologic malignancies. As such, it may have diagnostic utility in confirming hematolymphoid lineage in cases that are negative for CD45. Aberrant CD43 expression has been described in non-hematopoietic tumors, although literature data on this topic is variable and sometimes contradictory. To clarify and expand on existing literature findings, we evaluated CD43 expression by immunohistochemistry (IHC) in a large cohort (307) of non-hematopoietic neoplasms, including poorly differentiated malignancies...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28804643/local-staging-of-sigmoid-colon-cancer-using-mri
#15
Claus Dam, Jan Lindebjerg, Anders Jakobsen, Lars Henrik Jensen, Hans Rahr, Søren Rafael Rafaelsen
BACKGROUND: An accurate radiological staging of colon cancer is crucial to select patients who may benefit from neoadjuvant chemotherapy. PURPOSE: To evaluate the diagnostic accuracy of preoperative magnetic resonance imaging (MRI) in identifying locally advanced sigmoid colon cancer, poor prognostic factors, and the inter-observer variation of the tumor apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Using 1...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28743236/assessing-the-adequacy-of-lymph-node-yield-for-different-tumor-stages-of-colon-cancer-by-nodal-staging-scores
#16
Zhenyu Wu, Guoyou Qin, Naiqing Zhao, Huixun Jia, Xueying Zheng
BACKGROUND: According to the current official guidelines, at least 12 lymph nodes (LNs) are qualified as an adequate sampling for colon cancer patients. However, patients evaluated with less nodes were still common in the United States, and the prevalence of positive nodal disease may be under-estimated because of the false-negative assessment. In this study, we present a statistical model that allows preoperative determination of the minimum number of lymph nodes needed to confirm a node-negative disease with certain confidence...
July 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28681123/estrogen-receptor-%C3%AE-as-a-prognostic-marker-of-tumor-progression-in-colorectal-cancer-with-familial-adenomatous-polyposis-and-sporadic-polyps
#17
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Fábio de Oliveira Ferreira, Wilson Toshihiko Nakagawa, Ranyell Matheus Sobreira Batista Spencer, Tiago Santoro Bezerra, Philip Edward Boggiss, Ademar Lopes
The incidence of colorectal cancer (CRC) is lower in women than in men, and sex steroids can be considered contributing factors because oral contraception usage and estrogen replacement therapy are associated with decreased risk. Conversely, colorectal polyp development in familial adenomatous polyposis (FAP) begins during puberty. The objectives were to evaluate the relationship between the expression of these hormone receptors and adenoma-carcinoma progression, CRC stage and overall survival. We studied 120 A...
July 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28643309/-comparison-of-clinicopathological-features-and-prognosis-between-left-sided-colon-cancer-and-right-sided-colon-cancer
#18
Xianhua Gao, Guanyu Yu, Peng Liu, Liqiang Hao, Lianjie Liu, Wei Zhang
OBJECTIVE: To compare the clinicopathological features and prognosis between left-sided colon cancer (LC) and right-sided colon cancer (RC). METHODS: Clinicopathological and follow-up data of 2 174 colon carcinoma cases undergoing resection at Shanghai Changhai Hospital of The Second Military Medical University from January 2000 to December 2010 were retrospectively analyzed. Patients with transverse colon cancer, overlapping position, unknown location, recurrent cancer, multiple primary cancer, concomitant malignant tumors, preoperative chemotherapy, local resection, incomplete clinical data and missed follow up were excluded...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28616857/mr-imaging-features-of-intestinal-phytobezoar
#19
Lintao Qu, Jun Li, Bin Wang
PURPOSE: The aim of this study is to explore MR features and imaging mechanism of intestinal phytobezoar and to deepen the understanding of intestinal phytobezoar. METHODS: Eighteen cases of intestinal phytobezoar (including 15 cases in small intestine and 3 cases in colon) underwent MR examinations. Summing-up and analyzing MR features combinded with intraoperative findings. RESULTS: All 18 cases of intestinal phytobezoar showed irregular shape low signal on T2-weighted image, which was named coke sign in this study...
November 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28556280/endoscopic-submucosal-dissection-of-t1-cancer-with-colonic-diverticulum-by-pocket-creation-method
#20
LETTER
Naohisa Yoshida, Yuji Naito, Mitsuo Kishimoto
No abstract text is available yet for this article.
May 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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