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https://www.readbyqxmd.com/read/29768703/a-statistical-tool-for-risk-assessment-as-function-of-number-of-retrieved-lymph-nodes-from-rectal-cancer-patients
#1
Zhenyu Wu, Guoyou Qin, Naiqing Zhao, Huixun Jia, Xueying Zheng
PURPOSE: Although a minimum of 12 lymph nodes (LNs) has been recommended for colorectal cancer, there remains considerable debates for rectal cancer patients. Inadequacy of examined LNs would lead to under-staging, and inappropriate treatment as a consequence. We describe statistical tool that allows an estimate the probability of false-negative nodes. METHODS: A total of 26,778 adenocarcinoma rectum cancer patients with tumour stage (T stage) 1-3, diagnosed between 2004 and 2013, who did not receive neoadjuvant therapies and had at least one histologically assessed LN, were extracted from the Surveillance, Epidemiology and End Results (SEER) database...
May 16, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29766157/dual-acting-antitumor-pt-iv-prodrugs-of-kiteplatin-with-dichloroacetate-axial-ligands
#2
Salvatore Savino, Valentina Gandin, James D Hoeschele, Cristina Marzano, Giovanni Natile, Nicola Margiotta
With the aim to obtain dual acting drugs able to target both nuclear DNA and mitochondria, Pt(iv) kiteplatin derivatives having dichloroacetate (DCA) ligands in axial positions have been synthesized. The rather fast hydrolysis (t1/2 of ca. 1 h) and reduction (by ascorbic acid) of these Pt(iv) derivatives did not impede a potent pharmacological effect on tumor cells. Moreover, similarly to kiteplatin, also the Pt(iv)-DCA compounds proved to be capable of overcoming oxaliplatin-resistance, which is particularly important in view of the fact that metastatic colorectal cancer is the third most common cancer in males and the second in females...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29748707/risk-factors-of-recurrence-in-t1-colorectal-cancers-treated-by-endoscopic-resection-alone-or-surgical-resection-with-lymph-node-dissection
#3
Yuta Kouyama, Shin-Ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Shingo Matsudaira, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Fumio Ishida, Shigeharu Hamatani
PURPOSE: The recurrence of T1 colorectal cancers is relatively rare, and the prognostic factors still remain obscure. This study aimed to clarify the risk factors for recurrence in patients with T1 colorectal cancers treated by endoscopic resection (ER) alone or surgical resection (SR) with lymph node dissection, respectively. METHODS: We reviewed 930 patients with resected T1 colorectal cancers (mean follow-up, 52.3 months). Patients were divided into two groups: those who underwent ER alone (298 cases), and those who underwent initial or additional SR with lymph node dissection (632 cases)...
May 11, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29739071/cd24-overexpression-related-to-lymph-node-invasion-and-poor-prognosis-of-colorectal-cancer
#4
Ji-Lin Wang, Chun-Rong Guo, Wen-Yu Su, Ying-Xuan Chen, Jie Xu, Jing-Yuan Fang
BACKGROUND: Cluster of differentiation 24 (CD24) has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD24 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. METHODS: A comprehensive literature search was performed using Medline, Embase, Web of Science, and CNKI, and the statistical analysis was conducted using Stata software. RESULTS: A total of thirteen studies including 2,180 cases were included in this meta-analysis...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29731961/macrophages-induce-budding-in-aggressive-human-colon-cancer-subtypes-by-protease-mediated-disruption-of-tight-junctions
#5
Kari Trumpi, Nicola Frenkel, Timo Peters, Nicoline M Korthagen, Jennifer M J Jongen, Daniëlle Raats, Helma van Grevenstein, Yara Backes, Leon M Moons, Miangela M Lacle, Jan Koster, Danny Zwijnenburg, Inne H M Borel Rinkes, Onno Kranenburg
Primary human colorectal tumors with a high stromal content have an increased capacity to metastasize. Cancer-associated fibroblasts (CAFs) promote metastasis, but the contribution of other stromal cell types is unclear. Here we searched for additional stromal cell types that contribute to aggressive tumor cell behavior. By making use of the 'immunome compendium'-a collection of gene signatures reflecting the presence of specific immune cell-types-we show that macrophage signatures are most strongly associated with a high CAF content and with poor prognosis in multiple large cohorts of primary tumors and liver metastases...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29726125/long-term-oncological-outcomes-of-local-excision-versus-radical-resection-for-early-colorectal-cancer-in-young-patients-without-preoperative-chemoradiotherapy-a-population-based-propensity-matching-study
#6
Bin Cao, Li Min, Shengtao Zhu, Haiyun Shi, Shutian Zhang
The incidence and mortality of colorectal carcinoma are rising in young adults. This population-based propensity matching study aimed to compare long-term oncological outcomes of local excision with radical resection for early localized colorectal cancer (CRC) in young patients without preoperative chemoradiotherapy. Patients under 45 years old with T1 colon or rectal adenocarcinoma who underwent local excision or radical resection were included from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2014...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29713641/treatment-of-elderly-patients-with-colorectal-cancer
#7
REVIEW
Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. As society ages, the number of elderly patients with CRC will increase. The percentage of patients with right-sided colon cancer and the incidence of microsatellite instability are higher in elderly than in younger patients with CRC. Moreover, the higher incidence of comorbid diseases in elderly patients indicates the need for less invasive treatment strategies. For example, care should be taken in performing additional surgery after endoscopic submucosal dissection for elderly patients with high-risk T1 CRC...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29667054/connecting-gastrointestinal-cancer-risk-to-cadmium-and-lead-exposure-in-the-chaoshan-population-of-southeast-china
#8
Xueqiong Lin, Lin Peng, Xijin Xu, Yanrong Chen, Yuling Zhang, Xia Huo
Cadmium (Cd) and lead (Pb) pose a serious threat to human health because of its carcinogenicity. China ranks first according to the Global Cancer Report for 2014 in newly diagnosed gastrointestinal cancers and cancer deaths. The aim of the present study was to evaluate the association of Cd and Pb burden with the risk of gastrointestinal cancers in a hospital-based case-control study from southern regions of China, Chaoshan area. A total of 279 hospitalized patients were recruited in this study, of which 167 were gastrointestinal cancer cases (70 esophageal cancer, 51 gastric cancer, and 46 colorectal cancer), and 112 controls were recruited from two hospitals in the Chaoshan area of southeast China...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29652113/neutrophil-to-lymphocyte-ratio-nlr-predicts-risk-of-nodal-involvement-in-t1-colorectal-cancer-patients
#9
Damiano Caputo, Alessandro Coppola, Vincenzo LA Vaccara, Silvia Angeletti, Gianluca Rizzo, Massimo Ciccozzi, Claudio Coco, Roberto Coppola
BACKGROUND: Risk of nodal involvement in T1 colorectal cancer is assessed by tumor histological features. In several tumours, the ratio between neutrophils and lymphocytes (NLR) or platelets and lymphocytes (PLR) have been applied to lymph-node metastases prediction. The aim of this study was to evaluate the role of NLR, derived NLR (dNLR) and PLR in predicting nodal involvement in T1 colorectal cancers. METHODS: NLR, derived NLR (dNLR) and PLR in surgical resected T1 colorectal cancers were retrospectively calculated and analysed in nodal positive and negative cases...
April 12, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29650851/-a-case-of-isolated-lateral-pelvic-lymph-node-recurrence-after-tme-for-early-lower-rectal-cancer-treated-with-laparoscopic-lateral-lymph-node-dissection
#10
Ryuichiro Kimura, Masayoshi Yasui, Masayuki Ohue, Yusuke Takahashi, Norikatsu Miyoshi, Yoshitomo Yanagimoto, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Moon Jeong-Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Yoshiyuki Fujiwara, Hiroshi Miyata, Masahiko Yano, Masato Sakon
There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29627288/multiparametric-whole-body-mri-with-diffusion-weighted-imaging-and-adc-mapping-for-the-identification-of-visceral-and-osseous-metastases-from-solid-tumors
#11
Michael A Jacobs, Katarzyna J Macura, Atif Zaheer, Emmanuel S Antonarakis, Vered Stearns, Antonio C Wolff, Thorsten Feiweier, Ihab R Kamel, Richard L Wahl, Li Pan
RATIONALE AND OBJECTIVES: The purpose of this study was to investigate the use of multiparametric, whole-body, diffusion-weighted imaging (WB-DWI) and apparent diffusion coefficient (ADC) maps with T2 -weighted magnetic resonance imaging (MRI) at 3T for the detection and monitoring of metastatic disease in patients. MATERIALS AND METHODS: Fifty-four participants (32 healthy subjects and 22 patients) were scanned with WB-DWI methods using a 3T MRI scanner. Axial, sagittal, or coronal fat-suppressed T2 -weighted (T2 WI), T1 -weighted (T1 WI), and DWI images were acquired...
April 4, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29482251/-french-comment-on-article-artificial-intelligence-may-help-in-predicting-the-need-for-additional-surgery-after-endoscopic-resection-of-t1-colorectal-cancer
#12
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Endoscopy
https://www.readbyqxmd.com/read/29477926/colorectal-intussusception-secondary-to-primary-rectal-melanoma-a-novel-case-report
#13
Colin McQuade, Peadar S Waters, Ciara O'Brien, Stephen Crowther, William Torreggiani, Dara O Kavanagh
INTRODUCTION: Intussusception in adults is a rare condition, accounting for just 5% of all cases. Approximately 50% of cases of large intestine intussusception occur due to a malignant neoplasm. We present here a novel case report of colo-rectal intussusception arising secondary to a primary rectal melanoma. PRESENTATION OF CASE: We present the case of an 85 year-old patient, who underwent a colonoscopy for investigation of weight loss and altered bowel habit. At colonoscopy, a pigmented polypoid mass was visualised in the upper third of the rectum...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29456729/expression-of-matrix-metalloproteinase-7-correlates-with-the-invasion-of-t1-colorectal-carcinoma
#14
Fumihiko Urushibara, Eisuke Shiozawa, Hideyuki Miyachi, Masashi Misawa, Tomonari Cho, Yusuke Takehara, Nana Arai, Toshitaka Funaki, Sakiko Tazawa, Mayumi Homma, Tomoko Norose, Mutsuko Omatsu, Toshiko Yamochi, Toshiaki Kunimura, Genshu Tate, Kazuho Honda, Ishida Fumio, Shin-Ei Kudo, Masafumi Takimoto
T1 colorectal carcinomas (CRCs) are an initial site of metastatic spread. Various risk factors for lymph node metastasis have been investigated in T1 CRCs. However, the major step in the entire process of metastasis remains unclear. In terms of carcinoma invasion and metastasis, matrix metalloproteinases (MMPs) have recently gained increasing attention. Notably, MMP-7 is frequently overexpressed in CRCs, but its implication has not been determined in T1 CRCs yet. The present study aimed to clarify the associations between the pathological risk factors of T1 CRCs and MMP-7...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29447923/the-significance-of-tumor-budding-in-t1-colorectal-carcinoma-the-most-reliable-predictor-of-lymph-node-metastasis-especially-in-endoscopically-resected-t1-colorectal-carcinoma
#15
So Jeong Lee, Ahrong Kim, Young Keum Kim, Won Young Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Geum Am Song, Do Youn Park
Endoscopic resection is widely recognized as a first-line treatment for T1 colorectal cancers (CRC), although additional surgical intervention may be indicated based on the risk of lymph node (LN) metastasis. However, risk factors for LN metastasis in T1 CRC not fully established. We investigated the clinicopathological features of T1 CRC and evaluated their association with lymph node metastasis in 133 cases of T1 CRC, consisting of 87 cases with first-line endoscopic resection (EMR) followed by additional surgery and 46 cases with primary surgical resection...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29445855/-treatment-strategy-for-early-stage-rectal-cancer-t1-carcinoma
#16
REVIEW
G Liebig-Hörl, C Puchner, M Gerken, M Klinkhammer-Schalke, A Fürst
BACKROUND: A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors...
February 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29423221/a-phase-i-clinical-trial-of-dtcapfs-a-derivative-of-a-novel-human-hormone-peptide-for-the-treatment-of-advanced-metastatic-solid-tumors
#17
Salomon M Stemmer, Ofer Benjaminov, Michael H Silverman, Uziel Sandler, Ofer Purim, Naomi Sender, Chen Meir, Pnina Oren-Apoteker, Joel Ohana, Yoram Devary
The aim of the present phase I first-in-human study was to investigate the safety/efficacy of dTCApFs (a novel hormone peptide that enters cells through the T1/ST2 receptor), in advanced/metastatic solid tumors. The primary objective of this open-label dose-escalation study was to determine the safety profile of dTCApFs. The study enrolled patients (aged ≥18 years) with pathologically confirmed locally advanced/metastatic solid malignancies, who experienced treatment failure or were unable to tolerate previous standard therapy...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29407693/the-value-of-red-blood-cell-distribution-width-in-diagnosis-of-patients-with-colorectal-cancer
#18
Dianyu Yang, Wenqiang Quan, Junlu Wu, Xiaoyi Ji, Yan Dai, Weidong Xiao, Helen Chew, Zujun Sun, Dong Li
BACKGROUND: Red blood cell distribution width (RDW) is a parameter of standard full blood count tests that reflects the size variability of erythrocytes In recent studies, RDW levels have been associated with ischemic heart disease, acute and chronic heart failure, hypertension, and inflammatory bowel disease. However, it is unclear whether RDW is associated with colorectal cancer. METHODS: Eighty-five patients were diagnosed with colorectal cancer. Fifty-four other patients each diagnosed with colon polyps during the same period served as the control group...
April 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29405471/quantitative-mri-in-murine-radiation-induced-rectocolitis-comparison-with-histopathological-inflammation-score
#19
Magaly Zappa, Sabrina Doblas, Dominique Cazals-Hatem, Fabien Milliat, Jérémy Lavigne, Fanny Daniel, Abelhak Jallane, Philippe Garteiser, Valérie Vilgrain, Eric Ogier-Denis, Bernard E Van Beers
Murine radiation-induced rectocolitis is considered to be a relevant animal model of gastrointestinal inflammation. The purpose of our study was to compare quantitative MRI and histopathological features in this gastrointestinal inflammation model. Radiation rectocolitis was induced by localized single-dose radiation (27 Gy) in Sprague-Dawley rats. T2 -weighted, T1 -weighted and diffusion-weighted MRI was performed at 7 T in 16 rats between 2 and 4 weeks after irradiation and in 10 control rats. Rats were sacrificed and the histopathological inflammation score of the colorectal samples was assessed...
April 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29397654/full-thickness-resection-device-for-complex-colorectal-lesions-in-high-risk-patients-as-a-last-resort-endoscopic-treatment-initial-clinical-experience-and-review-of-the-current-literature
#20
Edris Wedi, Beatrice Orlandini, Mark Gromski, Carlo Felix Maria Jung, Irina Tchoumak, Stephanie Boucher, Volker Ellenrieder, Jürgen Hochberger
The full-thickness resection device (FTRD) is a novel endoscopic device approved for the resection of colorectal lesions. This case-series describes the device and its use in high-risk patients with colorectal lesions and provides an overview of the potential indications in recently published data. Between December 2014 and September 2015, 3 patients underwent endoscopic full thickness resection using the FTRD for colorectal lesions: 1 case for a T1 adenocarcinoma in the region of a surgical anastomosis after recto-sigmoidectomy, 1 case for a non-lifting colonic adenoma with low-grade dysplasia in an 89-year old patient and 1 for a recurrent adenoma with high-grade dysplasia in a young patient with ulcerative rectocolitis who was under immunosuppression after renal transplantation...
January 2018: Clinical Endoscopy
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