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https://www.readbyqxmd.com/read/28431329/stealth-recombinant-human-serum-albumin-nanoparticles-conjugating-5-fluorouracil-augmented-drug-delivery-and-cytotoxicity-in-human-colon-cancer-ht-29-cells
#1
Ankita Sharma, Amanpreet Kaur, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
BACKGROUND AND OBJECTIVE: 5-Fluorouracil (5-FU) is a first-line chemotherapeutic drug in colorectal cancer. However, intravenous administration of 5-FU at the dose of 7-12mg/kg exhibits curbs like short half-life (20min) and toxic side-effects on bone marrow cells. Therefore, in present investigation, 5-FU was conjugated to poly (ethylene glycol) anchored recombinant human serum albumin nanoparticles (5-FU-rHSA-PEG-NPs) to improve the pharmacokinetic and therapeutic profiles. METHODS AND RESULTS: The mean particle size of 5-FU-rHSA-NPs was measured to be 44...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28417155/pelvic-floor-symptoms-and-quality-of-life-changes-during-first-pregnancy-a-prospective-cohort-study
#2
Rebecca G Rogers, Cara Ninivaggio, Kelly Gallagher, A Noelle Borders, Clifford Qualls, Lawrence M Leeman
INTRODUCTION AND HYPOTHESIS: We describe pelvic floor function in nulliparous pregnant women. MATERIALS AND METHODS: Nulliparous midwifery patients completed the Incontinence Severity Index (ISI), Pelvic Floor Impact Questionnaire (PFIQ-7), Wexner Fecal Incontinence Scale (W), and answered questions about sexual activity and perineal pain at baseline during the first (T1), second (T2), or third trimester (T3) and repeated in late T3. They also underwent a Pelvic Organ Prolapse Quantification (POP-Q) exam at their baseline visit...
April 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28413659/patient-gender-as-a-factor-associated-with-lymph-node-metastasis-in-t1-colorectal-cancer-a-systematic-review-and-meta-analysis
#3
Katsuro Ichimasa, Shin-Ei Kudo, Hideyuki Miyachi, Yuta Kouyama, Fumio Ishida, Toshiyuki Baba, Atsushi Katagiri, Kunihiko Wakamura, Takemasa Hayashi, Tomokazu Hisayuki, Toyoki Kudo, Masashi Misawa, Yuichi Mori, Shingo Matsudaira, Yui Kimura, Yuki Kataoka
Approximately 10% of patients with T1 colorectal cancer have lymph node metastases (LNM), requiring node dissection along with surgical resection. Patient gender was recently reported to affect the occurrence of LNM. The aim of the present study was to assess whether patient gender was predictive of LNM in T1 colorectal cancer. Public databases, including PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched, using key terms related to 'T1 colorectal cancer' and 'lymph node'. All relevant studies reporting the adjusted odds ratio or risk ratio of LNM in relation to patient gender were included...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28369939/potential-of-a-cure-in-patients-with-colorectal-liver-metastases-and-concomitant-extrahepatic-disease
#4
Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
BACKGROUND AND OBJECTIVES: We aimed to define the cure rate in patients with colorectal liver metastases (CRLM) and concomitant extrahepatic disease (EHD) on the 5-year disease-free survival (DFS) after surgery, and identify the factors for predicting a cure. METHODS: Patients who underwent hepatectomy for CRLM with concomitant EHD were identified. Those followed for >5 years after surgery were enrolled. A cure was defined as DFS of >5 years after the last curative surgery...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28356962/comparative-clinicopathological-characteristics-of-colon-and-rectal-t1-carcinoma
#5
Katsuro Ichimasa, Shin-Ei Kudo, Hideyuki Miyachi, Yuta Kouyama, Takemasa Hayashi, Kunihiko Wakamura, Tomokazu Hisayuki, Toyoki Kudo, Masashi Misawa, Yuichi Mori, Shingo Matsudaira, Eiji Hidaka, Shigeharu Hamatani, Fumio Ishida
Lymph node metastasis significantly influences the management of patients with colorectal carcinoma. It has been observed that the biology of colorectal carcinoma differs by location. The aim of the current study was to retrospectively compare the clinicopathological characteristics of patients with colon and rectal T1 carcinomas, particularly their rates of lymph node metastasis. Of the 19,864 patients who underwent endoscopic or surgical resection of colorectal neoplasms at Showa University Northern Yokohama Hospital, 557 had T1 surgically resected carcinomas, including 457 patients with colon T1 carcinomas and 100 patients with rectal T1 carcinomas...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28349592/clinical-impact-of-surveillance-colonoscopy-using-magnification-without-diminutive-polyp-removal
#6
Yuki Ninomiya, Shiro Oka, Shinji Tanaka, Kazuki Boda, Ken Yamashita, Kyoku Sumimoto, Daiki Hirano, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Taiji Matsuo, Kazuaki Chayama
BACKGROUND AND AIM: Endoscopic removal of all adenomas during colonoscopy is recommended in Western countries. This study evaluated the usefulness of magnifying colonoscopy without removal of diminutive (≤ 5 mm) colorectal polyps. METHODS: Patients with diminutive polyps who were observed for over 5 years using magnification at Hiroshima University Hospital were selected retrospectively. Lesions ≥ 6 mm in size, depressed lesions, and lesions with type V pit pattern were indications for endoscopic resection...
March 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28323275/risk-for-incomplete-resection-after-macroscopic-radical-endoscopic-resection-of-t1-colorectal-cancer-a-multicenter-cohort-study
#7
Y Backes, W H de Vos Tot Nederveen Cappel, J van Bergeijk, F Ter Borg, M P Schwartz, B W M Spanier, J M J Geesing, K Kessels, M Kerkhof, J N Groen, F H J Wolfhagen, T C J Seerden, N van Lelyveld, G J A Offerhaus, P D Siersema, M M Lacle, L M G Moons
OBJECTIVES: The decision to perform secondary surgery after endoscopic resection of T1 colorectal cancer (CRC) depends on the risk of lymph node metastasis and the risk of incomplete resection. We aimed to examine the incidence and risk factors for incomplete endoscopic resection of T1 CRC after a macroscopic radical endoscopic resection. METHODS: Data from patients treated between 2000 and 2014 with macroscopic complete endoscopic resection of T1 CRC were collected from 13 hospitals...
March 21, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28301099/comparison-of-four-mri-protocols-for-detection-of-extrahepatic-colorectal-cancer-metastases
#8
Kim Sivesgaard, Maria Louise Jöhnk, Lars P Larsen, Michael Sørensen, Stine Kramer, Vibeke Berg Løgager, Flemming Hansen, Erik Morre Pedersen
PURPOSE: To compare three magnetic resonance imaging (MRI) protocols containing diffusion-weighted imaging with background suppression (DWIBS) and one traditional protocol for detecting extrahepatic colorectal cancer metastases. MATERIALS AND METHODS: Thirty patients with extrahepatic colorectal cancer metastases were scanned in three stations from the skull base to the upper thighs using a 1.5T MRI system with six different MRI sequences; transverse and coronal T2 -weighted (T2 W) turbo spin-echo (TSE), coronal short tau inversion recovery (STIR), 3D T1 W TSE, DWIBS, and a contrast-enhanced T1 W 3D gradient echo (GRE) sequence...
March 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28270669/a-trend-of-preference-of-magnifying-chromoendoscopy-to-narrow-band-imaging-in-diagnosis-of-t1-colorectal-cancer-with-deep-invasion-could-be-observed
#9
Qing-Wei Zhang, Xin-Tian Zhang, Ying Zhou, Zhi-Zheng Ge, Xiao-Bo Li
No abstract text is available yet for this article.
March 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28260648/impact-of-freeze-thaw-cycles-on-circulating-inflammation-marker-measurements
#10
Wen-Yi Huang, Troy J Kemp, Ruth M Pfeiffer, Ligia A Pinto, Allan Hildesheim, Mark P Purdue
BACKGROUND: Circulating inflammation markers are being increasingly measured in prospective cohorts to investigate cancer etiology. However, it is unclear how the measurements are affected by the freeze-thaw cycles of the specimens prior to marker analysis. METHODS: We compared concentrations of 45 inflammation markers between paired serum vials of 55 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial that have undergone one (T1), two (T2), and three (T3) freeze-thaw cycles at the time of assay...
March 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28258664/surgical-and-not-analgesic-technique-affects-postoperative-inflammation-following-colorectal-cancer-surgery-a-prospective-randomized-study
#11
W Siekmann, C Eintrei, A Magnuson, A Sjölander, P Matthiessen, P Myrelid, A Gupta
AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery. METHODS: 96 patients scheduled for open or laparoscopic surgery were randomized to epidural analgesia (group E) or patient controlled intravenous analgesia (group P)...
March 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28251101/comparative-analysis-of-colorectal-carcinoma-staging-using-operative-histopathology-and-computed-tomography-findings
#12
Subhash Chander Singla, Dhawal Kaushal, Harinder Singh Sagoo, Nalini Calton
BACKGROUND: The staging of colorectal carcinoma using 3 modalities viz operative, histopathology and CT scan has been subject of interest in accurately defining the extent of disease. This retrospective as well as prospective study was carried out at CMC, Ludhiana, Punjab from November 2011 to May 2014. AIM: The objective of this study was to assess the usefulness and accuracy of CT scan findings to state the extent and spread of colorectal malignancy and to correlate these findings with histopathological diagnosis...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28194568/t1-colon-cancer-in-the-era-of-screening-risk-factors-and-treatment
#13
F Bianco, S De Franciscis, A Belli, A Falato, R Fusco, D F Altomare, A Amato, C R Asteria, A Avallone, G A Binda, L Boccia, P Buzzo, M Carvello, C Coco, P Delrio, P De Nardi, M Di Lena, A Failla, F La Torre, M La Torre, M Lemma, P Luffarelli, G Manca, I Maretto, F Marino, A Muratore, A Pascariello, S Pucciarelli, D Rega, V Ripetti, G Rizzo, A Serventi, A Spinelli, F Tatangelo, E D L Urso, G M Romano
BACKGROUND: The aim of this study was to identify risk factors for lymph node positivity in T1 colon cancer and to carry out a surgical quality assurance audit. METHODS: The sample consisted of consecutive patients treated for early-stage colon lesions in 15 colorectal referral centres between 2011 and 2014. The study investigated 38 factors grouped into four categories: demographic information, preoperative data, indications for surgery and post-operative data...
February 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28194526/long-term-outcomes-after-treatment-for-t1-colorectal-carcinoma-a-multicenter-retrospective-cohort-study-of-hiroshima-gi-endoscopy-research-group
#14
Yuzuru Tamaru, Shiro Oka, Shinji Tanaka, Shinji Nagata, Yuko Hiraga, Toshio Kuwai, Akira Furudoi, Tadamasa Tamura, Masaki Kunihiro, Hideharu Okanobu, Koichi Nakadoi, Hiroyuki Kanao, Makoto Higashiyama, Koji Arihiro, Kazuya Kuraoka, Fumio Shimamoto, Kazuaki Chayama
BACKGROUND: We aimed to clarify the long-term outcomes of patients with T1 colorectal carcinoma (CRC) after endoscopic resection (ER) and surgical resection. METHODS: We examined T1 CRC patients treated during 1992-2008 and who had ≥5 years of follow-up. Patients who did not meet the curative criteria after ER according to the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines were defined as "non-endoscopically curable" and classified into three groups: ER alone (Group A: 121 patients), additional surgery after ER (Group B: 238 patients), and surgical resection alone (Group C: 342 patients)...
February 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28169236/the-clinical-and-pathological-features-affecting-the-time-of-relapse-in-patients-with-early-stage-colorectal-cancer
#15
Doğan Yazilitas, Nuriye Özdemir, Ozan Yazıcı, Cemil Hocazade, Nebi Serkan Demirci, Nurullah Zengin
BACKGROUND: The relapses of colorectal cancer (CRC) frequently occur in 2 years period after the time of diagnosis. However, a considerable proportion of patients relapse in the late period. AIM: The aim of the present study is to define the factors predicting the early and late relapses of patients with early stage CRC. MATERIALS AND METHODS: A total of 250 patients with CRC, who relapsed after completion of primary therapy between 2005 and 2014, were enrolled in the study...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28052292/evaluation-for-the-clinical-efficacy-of-colon-capsule-endoscopy-in-the-detection-of-laterally-spreading-tumors
#16
COMPARATIVE STUDY
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
https://www.readbyqxmd.com/read/27992283/transanal-endoscopic-microsurgery-combined-with-laparoscopic-colectomy-for-synchronous-colorectal-tumors-a-word-of-caution
#17
Nida Issa, Yaniv Fenig, Muhammad Khatib, Mustafa Yasin, Eldad Powsner, Wisam Khoury
BACKGROUND: The incidence of malignant synchronous colorectal tumors (SCRT) is between 2% and 5%, and the association of synchronous adenomatous polyps in colon cancer has been reported to be 15%-50%. Surgical resection is the primary treatment option for SCRT not amendable to endoscopic resection. Lesions in adjacent segments are usually treated with more extensive resection; however, there is still some controversy on how to best treat synchronous lesions in separate segments, especially when the rectum is involved...
December 19, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27926556/natural-orifice-specimen-extraction-with-single-stapling-colorectal-anastomosis-for-laparoscopic-anterior-resection-feasibility-outcomes-and-technical-considerations
#18
Bansal Saurabh, Sheng-Chi Chang, Tao-Wei Ke, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, William Tzu-Liang Chen, Abe Fingerhut
BACKGROUND: Double and triple stapling techniques to close the rectal stump in laparoscopic anterior resection are fraught with technical drawbacks that could possibly be avoided with the use of the single stapling technique. However, little is known of its safety in laparoscopic surgery or outcomes when combined with natural orifice specimen extraction. OBJECTIVE: This study aims to analyze the feasibility and the operative and immediate postoperative outcomes of single-stapled anastomosis and natural orifice specimen extraction with conventional techniques...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27885555/meat-intake-cooking-methods-and-doneness-and-risk-of-colorectal-tumours-in-the-spanish-multicase-control-study-mcc-spain
#19
Jordi de Batlle, Esther Gracia-Lavedan, Dora Romaguera, Michelle Mendez, Gemma Castaño-Vinyals, Vicente Martín, Núria Aragonés, Inés Gómez-Acebo, Rocío Olmedo-Requena, José Juan Jimenez-Moleon, Marcela Guevara, Mikel Azpiri, Cristóbal Llorens-Ivorra, Guillermo Fernandez-Tardon, Jose Andrés Lorca, José María Huerta, Victor Moreno, Elena Boldo, Beatriz Pérez-Gómez, Jesús Castilla, Tania Fernández-Villa, Juan Pablo Barrio, Montserrat Andreu, Antoni Castells, Trinidad Dierssen, Jone M Altzibar, Manolis Kogevinas, Marina Pollán, Pilar Amiano
PURPOSE: Although there is convincing evidence that red and processed meat intake increases the risk of colorectal cancer (CRC), the potential role of meat cooking practices has not been established yet and could partly explain the current heterogeneity of results among studies. Therefore, we aimed to investigate the association between meat consumption and cooking practices and the risk of CRC in a population-based case-control study. METHODS: A total of 1671 CRC cases and 3095 controls recruited in Spain between September 2008 and December 2013 completing a food frequency questionnaire with a meat-specific module were included in the analyses...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27855352/primary-hepatic-schwannoma-a-case-report
#20
Masaki Yamamoto, Kiyoshi Hasegawa, Junichi Arita, Ryohei Maeno, Nobuhisa Akamatsu, Junichi Kaneko, Takeyuki Watadani, Naoki Okura, Akimasa Hayashi, Junji Shibahara, Yoshihiro Sakamoto, Kuni Ohtomo, Masashi Fukayama, Norihiro Kokudo
INTRODUCTION: A hepatic schwannoma is extremely rare and difficult to diagnose preoperatively. PRESENTATION OF CASE: We report the case of a 47-year-old male patient who was referred to our hospital for the close investigation of a hepatic tumor which had not been detected two years earlier. An enhanced computed tomography revealed a well-circumscribed and encapsulated tumor with a size of 50mm which was adjacent to the inferior vena cava (IVC) and the right hepatic vein...
2016: International Journal of Surgery Case Reports
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