keyword
MENU ▼
Read by QxMD icon Read
search

t1 colorectal

keyword
https://www.readbyqxmd.com/read/29310604/a-modified-tnm-staging-system-for-non-metastatic-colorectal-cancer-based-on-nomogram-analysis-of-seer-database
#1
Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan, Kefeng Ding
BACKGROUND: To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rationality of enhancing T stage's weighting in our previously proposed T-plus staging system. METHODS: Total 115,377 non-metastatic CRC patients from SEER were randomly grouped as training and testing set by ratio 1:1. The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29298873/multicentre-prospective-evaluation-of-real-time-optical-diagnosis-of-t1-colorectal-cancer-in-large-non-pedunculated-colorectal-polyps-using-narrow-band-imaging-the-optical-study
#2
Yara Backes, Matthijs P Schwartz, Frank Ter Borg, Frank H J Wolfhagen, John N Groen, Wouter H de Vos Tot Nederveen Cappel, Jeroen van Bergeijk, Joost M J Geesing, Bernhard W M Spanier, Paul Didden, Frank P Vleggaar, Miangela M Lacle, Sjoerd G Elias, Leon M G Moons
OBJECTIVE: This study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs). DESIGN: In this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29261319/facile-deposition-of-manganese-dioxide-to-albumin-bound-paclitaxel-nanoparticles-for-modulation-of-hypoxic-tumor-microenvironment-to-improve-chemoradiation-therapy
#3
Lingtong Meng, Yali Cheng, Shaoju Gan, Zhicheng Zhang, Xiaoning Tong, Lei Xu, Xing Jiang, Yishen Zhu, Jinhui Wu, Ahu Yuan, Yiqiao Hu
Tumor microenvironment with hypoxia and excess hydrogen peroxide (H2O2), tremendously limits the effect of chemoradiation therapy of colorectal cancer. For the first time, we developed a facile method to deposit manganese dioxide (MnO2) on the surface of albumin bound paclitaxel nanoparticles (ANPs-PTX) to obtain MnO2 functioned ANPs-PTX (MANPs-PTX). In the tumor microenvironment, MANPs-PTX could consume excess hydrogen peroxide (H2O2) to produce abundant oxygen for tumor oxygenation and improve chemoradiation therapy...
December 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29250584/endoscopic-full-thickness-resection-for-t1-early-rectal-cancer-a-case-series-and-video-report
#4
Paola Soriani, Gian Eugenio Tontini, Helmut Neumann, Germana de Nucci, Domenico De Toma, Barbara Bruni, Sara Vavassori, Luca Pastorelli, Maurizio Vecchi, Pavlos Lagoussis
Background and study aims:  Endoscopic treatment of malignant colorectal polyps is often challenging, especially for early rectal cancer (ERC) localized close to the dentate line. Conversely, the surgical approach may result in temporary or definitive stoma and in frequent post-surgical complications. The Full-Thickness Resection Device (FTRD ® ) System (Ovesco Endoscopy, Tübingen, Germany) is a novel system that, besides having other indications, appears to be promising for wall-thickness excision of intestinal T1 carcinoma following incomplete endoscopic resection...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29233113/clinicopathologic-and-endoscopic-features-of-early-stage-colorectal-serrated-adenocarcinoma
#5
Daiki Hirano, Shiro Oka, Shinji Tanaka, Kyoku Sumimoto, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Yuji Urabe, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
BACKGROUND: Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aimed to clarify the clinicopathologic and endoscopic characteristics of early-stage SACs. METHODS: Forty consecutive early-stage SAC patients at Hiroshima University Hospital were enrolled; SACs were classified into epithelial serration (Group A, n = 17) and non-epithelial serration (Group B, n = 23) groups...
December 12, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29231608/-influence-of-electroacupuncture-pretreatment-on-intestinal-function-in-the-patients-of-colorectal-cancer-surgery
#6
Sicong Mai, Jinhai Meng, Wenjuan Wang, Shuhui Lang
OBJECTIVE: To observe the effects of electroacupuncture (EA) pretreatment on the intestinal function, inflammatory reaction and blood lactic acid in the patients of colorectal cancer surgery. METHODS: Sixty patients of colorectal cancer laparotomy at selective period, aged from 18 to 59 years old were selected. According toⅠ-Ⅲ grade of American Society of Anesthesiologists (ASA), the patients were randomized into group A (total intravenous anesthesia), group B[total intravenous anesthesia combined with EA pretreatment at Zusanli (ST 36), Shangjuxu (ST 37) and Xiajuxu (ST 39) on the right side] and group C[total intravenous anesthesia combined with EA pretreatment at Zhongwan (CV 12), Tianshu (ST 25), Zusanli (ST 36), Shangjuxu (ST 37) and Xiajuxu (ST 39) on the right side], 20 cases in each one...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29218320/predictive-relevance-of-lymphovascular-invasion-in-t1-colorectal-cancer-before-endoscopic-treatment
#7
Kazuya Inoki, Taku Sakamoto, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hirokazu Taniguchi, Shigeki Sekine, Yukihide Kanemitsu, Yuichiro Ohe, Yutaka Saito
Background and aim:  The depth of tumor invasion is currently the only reliable predictive risk factor for lymph node metastasis before endoscopic treatment for colorectal cancer. However, the most important factor to predict lymph node metastasis has been suggested to be lymphovascular invasion rather than the depth of invasion. Thus, the aim of this study was to investigate the predictive relevance of lymphovascular invasion before endoscopic treatment. Methods:  The data on pT1 colorectal cancers that were resected endoscopically or surgically from 2007 to 2015 were retrospectively reviewed...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29204060/post-colonoscopy-colorectal-cancer-rate-in-the-era-of-high-definition-colonoscopy
#8
Mineo Iwatate, Tomoyuki Kitagawa, Yasumi Katayama, Naohiko Tokutomi, Shinichi Ban, Santa Hattori, Noriaki Hasuike, Wataru Sano, Yasushi Sano, Masaya Tamano
AIM: To investigate the post-colonoscopy colorectal cancer (PCCRC) rate for high-definition (HD) colonoscopy compared with that for standard-definition colonoscopy reported previously. METHODS: Using medical records at Sano Hospital (SH) and Dokkyo Medical University Koshigaya Hospital (DMUKH), we retrospectively obtained data on consecutive patients diagnosed as having CRC between January 2010 and December 2015. The definition of PCCRC was diagnosis of CRC between 7 and 36 mo after initial high-definition colonoscopy that had detected no cancer, and patients were divided into a PCCRC group and a non-PCCRC group...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29199088/a-microrna-signature-associated-with-metastasis-of-t1-colorectal-tumors-to-lymph-nodes
#9
Tsuyoshi Ozawa, Raju Kandimalla, Feng Gao, Hiroaki Nozawa, Keisuke Hata, Hiroshi Nagata, Satoshi Okada, Daisuke Izumi, Hideo Baba, James Fleshman, Xin Wang, Toshiaki Watanabe, Ajay Goel
Most T1 colorectal tumors treated by radical surgery can now be cured by endoscopic submucosal dissection. Although 70%-80% of T1 colorectal tumors are classified as high risk, fewer than 16% of these patients actually have lymph node metastases. Biomarkers are needed to identify patients with T1 tumors with the highest risk of metastasis, to prevent unnecessary radical surgeries. We collected data from the Cancer Genome Atlas and identified 5 microRNAs (MIR32, MIR181B, MIR193B, MIR195, and MIR 411) with significant changes in expression in T1 and T2 colorectal tumors with vs without lymphatic invasion...
November 30, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29184880/histopathologic-risk-factors-for-lymph-node-metastasis-in-patients-with-t1-colorectal-cancer
#10
Ryun Kyong Ha, Kyung Su Han, Dae Kyung Sohn, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Jong Hee Hyun, Min Jung Kim, Sung Chan Park, Jae Hwan Oh
Purpose: Evaluating the risk of lymph node metastasis (LNM) is critical for determining subsequent treatments following endoscopic resection of T1 colorectal cancer (CRC). This study analyzed histopathologic risk factors for LNM in patients with T1 CRC. Methods: This study involved 745 patients with T1 CRC who underwent endoscopic (n = 97) or surgical (n = 648) resection between January 2001 and December 2015 at the National Cancer Center, Korea. LNM in endoscopically resected patients, which could not be evaluated directly, was estimated indirectly based on follow-up results and histopathologic reports of salvage surgery...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29177161/early-gastroenteropancreatic-neuroendocrine-tumors-endoscopic-therapy-and-surveillance
#11
REVIEW
Hans Scherübl, Guillaume Cadiot
Neuroendocrine neoplasias (NEN) of the stomach, duodenum, pancreas, appendix, or rectum that are ≤1 cm in size as well as well-differentiated with World Health Organization grade 1 (G1) can be considered 'early' neuroendocrine tumors; they have a very good prognosis. Regarding prognosis, neuroendocrine tumors (NET) G1 must be distinguished from well-differentiated NET G2 and poorly differentiated neuroendocrine carcinomas (NEC) G3. NET are increasing, with a rise in the age-adjusted incidence in the USA by about 700% in the last 40 years...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29175408/circadian-variations-in-the-pharmacokinetics-of-capecitabine-and-its-metabolites-in-rats
#12
Shinji Kobuchi, Yukiko Yazaki, Yukako Ito, Toshiyuki Sakaeda
Capecitabine, an orally available prodrug of 5-fluorouracil, is widely used to treat patients with colorectal cancer. Although various studies have shown circadian variations in plasma 5-fluorouracil concentrations during long-term infusion, it is still unknown whether circadian variations also exist following administration of capecitabine. The present study aimed to investigate whether the pharmacokinetics of capecitabine and its metabolites, including 5-fluorouracil, vary according to administration time in rats...
November 23, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29137091/the-effects-of-hypervolemic-infusion-on-microcirculation-perfusion-of-patients-during-laparoscopic-colorectal-surgery
#13
RANDOMIZED CONTROLLED TRIAL
Yunxin Deng, Qianlin Zhu, Buwei Yu, Minhua Zheng, Jue Jin
The aim of this study is to assess the effects of hypervolemic infusion with different solutions on microcirculation perfusion during laparoscopic colorectal surgery.Thirty-six patients were randomly divided into Ringer lactate solution [RL] group, succinylated gelatin injection [Gel] group, and hypertonic saline hydroxyethyl starch 40 injection [HS] group. Hypervolemic infusion was performed during the induction period of general anesthesia. Arterial blood-gas parameters, noninvasive hemodynamics, gastric tonometry values, and central venous pressure (CVP) were compared at baseline (T1); the end of hypervolemic infusion (T2); 5 min (T3), 15 min (T4), 30 min (T5), and 60 min (T6) during pneumoperitoneum; 5 min (T7), 15 min (T8), and 25 min (T9) after pneumoperitoneum...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29133757/soluble-triggering-receptor-expressed-on-myeloid-cells-1-and-inflammatory-markers-in-colorectal-cancer-surgery-a-prospective-cohort-study
#14
Lovorka Ðerek, Dražen Servis, Adriana Unić
BACKGROUND: Major abdominal surgery, including colorectal cancer (CRC) surgery, leads to systemic inflammatory response syndrome that can be detected and monitored with inflammatory markers testing. The aims of the study were to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) in following the inflammatory response in CRC surgery and postoperative period, as well as to determine if duration of the surgery and the time that the colon has been opened during the surgery (open colon time [OCT]) reflect a larger surgical stress through inflammatory markers rise...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29132333/oestrogen-receptor-beta-isoform-expression-in-sporadic-colorectal-cancer-familial-adenomatous-polyposis-and-progressive-stages-of-colorectal-cancer
#15
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. METHODS: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29120905/fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-pet-ct-can-predict-prognosis-in-patients-with-colorectal-cancer-after-curative-surgical-resection
#16
Jeong Won Lee, Moo-Jun Baek, Tae Sung Ahn, Sang Mi Lee
OBJECTIVE: This study investigated the relationship of fluorine-18-fluorodeoxyglucose (F-FDG) uptake of bone marrow (BM) on PET/computed tomography (PET/CT) with clinicopathologic factors and survival in patients with colorectal cancer. PATIENTS AND METHODS: The study retrospectively included 226 patients with colorectal cancer who underwent F-FDG PET/CT for staging workup and treated with curative surgical resection. The maximum F-FDG uptake of primary cancer (Tmax) and mean F-FDG uptake of BM [BM standardized uptake value (SUV)] were derived from PET/CT images...
November 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29112994/risk-of-recurrence-after-endoscopic-resection-of-early-colorectal-cancer-with-positive-margins
#17
Je-Wook Shin, Kyung Su Han, Jong Hee Hyun, Sang Jae Lee, Bun Kim, Chang Won Hong, Byung Chang Kim, Dae Kyung Sohn, Hee Jin Chang, Min Jung Kim, Sung Chan Park, Jae Hwan Oh
Background and study aim Additional surgery is recommended if an endoscopically resected T1 colorectal cancer (CRC) specimen shows a positive resection margin. We aimed to investigate the significance of a positive resection margin in endoscopically resected T1 CRC. Patients and methods We enrolled 265 patients with T1 CRC who underwent endoscopic resection between January 2001 and December 2016. The inclusion criteria were: 1) complete resection by endoscopy, and 2) pathology of a positive margin. Among the 265 patients, 213 underwent additional surgery and 52 did not...
November 7, 2017: Endoscopy
https://www.readbyqxmd.com/read/29098429/clinical-outcomes-of-deep-invasive-submucosal-colorectal-cancer-after-esd
#18
Daisuke Watanabe, Takashi Toyonaga, Makoto Ooi, Tetsuya Yoshizaki, Yoshiko Ohara, Shinwa Tanaka, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeru Matsuda, Yasuo Sumi, Mari Nishio, Hiroshi Yokozaki, Takeshi Azuma
BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery under certain conditions. However, limited information is available on the clinical course of T1b colorectal cancer (CRC) after ESD. The aim of the study was to clarify the feasibility of ESD for T1b CRC. PATIENTS AND METHODS: Three hundred and two patients with 312 T1 CRC were identified in this retrospective cohort study. All patients were treated with ESD, other endoscopic treatments, or surgery...
November 2, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29095681/randomized-trial-of-conquerfear-a-novel-theoretically-based-psychosocial-intervention-for-fear-of-cancer-recurrence
#19
RANDOMIZED CONTROLLED TRIAL
Phyllis N Butow, Jane Turner, Jemma Gilchrist, Louise Sharpe, Allan Ben Smith, Joanna E Fardell, Stephanie Tesson, Rachel O'Connell, Afaf Girgis, Val J Gebski, Rebecca Asher, Cathrine Mihalopoulos, Melanie L Bell, Karina Grunewald Zola, Jane Beith, Belinda Thewes
Purpose Fear of cancer recurrence (FCR) is prevalent, distressing, and long lasting. This study evaluated the impact of a theoretically/empirically based intervention (ConquerFear) on FCR. Methods Eligible survivors had curable breast or colorectal cancer or melanoma, had completed treatment (not including endocrine therapy) 2 months to 5 years previously, were age > 18 years, and had scores above the clinical cutoff on the FCR Inventory (FCRI) severity subscale at screening. Participants were randomly assigned at a one-to-one ratio to either five face-to-face sessions of ConquerFear (attention training, metacognitions, acceptance/mindfulness, screening behavior, and values-based goal setting) or an attention control (Taking-it-Easy relaxation therapy)...
December 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29067939/a-case-of-total-laparoscopic-sigmoidectomy-involving-the-use-of-needle-forceps-and-transanal-specimen-extraction-for-sigmoid-colon-cancer
#20
Rina Takahashi, Kazuhiro Sakamoto, Hisashi Ro, Kazumasa Kure, Masaya Kawai, Shun Ishiyama, Kiichi Sugimoto, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki
A 76-year-old male underwent endoscopic mucosal resection for a stage T1 tumour of the sigmoid colon. We performed laparoscopic sigmoidectomy through 5 ports using needlescopic instruments. The resected specimen was extracted from the abdominal cavity transanally. After attaching an anvil to the sigmoidal stump, the rectal stump was reclosed using an endoscopic linear stapler, and then, colorectal anastomosis was conducted using the double stapling technique. Performing transanal specimen extraction using needlescopic forceps improves aesthetic outcomes and reduces post-operative pain and the risk of abdominal incisional hernias...
October 23, 2017: Journal of Minimal Access Surgery
keyword
keyword
71119
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"