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https://www.readbyqxmd.com/read/28052292/evaluation-for-the-clinical-efficacy-of-colon-capsule-endoscopy-in-the-detection-of-laterally-spreading-tumors
#1
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
https://www.readbyqxmd.com/read/27992283/transanal-endoscopic-microsurgery-combined-with-laparoscopic-colectomy-for-synchronous-colorectal-tumors-a-word-of-caution
#2
Nida Issa, Yaniv Fenig, Muhammad Khatib, Mustafa Yasin, Eldad Powsner, Wisam Khoury
BACKGROUND: The incidence of malignant synchronous colorectal tumors (SCRT) is between 2% and 5%, and the association of synchronous adenomatous polyps in colon cancer has been reported to be 15%-50%. Surgical resection is the primary treatment option for SCRT not amendable to endoscopic resection. Lesions in adjacent segments are usually treated with more extensive resection; however, there is still some controversy on how to best treat synchronous lesions in separate segments, especially when the rectum is involved...
December 19, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27926556/natural-orifice-specimen-extraction-with-single-stapling-colorectal-anastomosis-for-laparoscopic-anterior-resection-feasibility-outcomes-and-technical-considerations
#3
Bansal Saurabh, Sheng-Chi Chang, Tao-Wei Ke, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, William Tzu-Liang Chen, Abe Fingerhut
BACKGROUND: Double and triple stapling techniques to close the rectal stump in laparoscopic anterior resection are fraught with technical drawbacks that could possibly be avoided with the use of the single stapling technique. However, little is known of its safety in laparoscopic surgery or outcomes when combined with natural orifice specimen extraction. OBJECTIVE: This study aims to analyze the feasibility and the operative and immediate postoperative outcomes of single-stapled anastomosis and natural orifice specimen extraction with conventional techniques...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27885555/meat-intake-cooking-methods-and-doneness-and-risk-of-colorectal-tumours-in-the-spanish-multicase-control-study-mcc-spain
#4
Jordi de Batlle, Esther Gracia-Lavedan, Dora Romaguera, Michelle Mendez, Gemma Castaño-Vinyals, Vicente Martín, Núria Aragonés, Inés Gómez-Acebo, Rocío Olmedo-Requena, José Juan Jimenez-Moleon, Marcela Guevara, Mikel Azpiri, Cristóbal Llorens-Ivorra, Guillermo Fernandez-Tardon, Jose Andrés Lorca, José María Huerta, Victor Moreno, Elena Boldo, Beatriz Pérez-Gómez, Jesús Castilla, Tania Fernández-Villa, Juan Pablo Barrio, Montserrat Andreu, Antoni Castells, Trinidad Dierssen, Jone M Altzibar, Manolis Kogevinas, Marina Pollán, Pilar Amiano
PURPOSE: Although there is convincing evidence that red and processed meat intake increases the risk of colorectal cancer (CRC), the potential role of meat cooking practices has not been established yet and could partly explain the current heterogeneity of results among studies. Therefore, we aimed to investigate the association between meat consumption and cooking practices and the risk of CRC in a population-based case-control study. METHODS: A total of 1671 CRC cases and 3095 controls recruited in Spain between September 2008 and December 2013 completing a food frequency questionnaire with a meat-specific module were included in the analyses...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27855352/primary-hepatic-schwannoma-a-case-report
#5
Masaki Yamamoto, Kiyoshi Hasegawa, Junichi Arita, Ryohei Maeno, Nobuhisa Akamatsu, Junichi Kaneko, Takeyuki Watadani, Naoki Okura, Akimasa Hayashi, Junji Shibahara, Yoshihiro Sakamoto, Kuni Ohtomo, Masashi Fukayama, Norihiro Kokudo
INTRODUCTION: A hepatic schwannoma is extremely rare and difficult to diagnose preoperatively. PRESENTATION OF CASE: We report the case of a 47-year-old male patient who was referred to our hospital for the close investigation of a hepatic tumor which had not been detected two years earlier. An enhanced computed tomography revealed a well-circumscribed and encapsulated tumor with a size of 50mm which was adjacent to the inferior vena cava (IVC) and the right hepatic vein...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27832648/-head-invasion-is-not-a-metastasis-free-condition-in-pedunculated-t1-colorectal-carcinomas-based-on-the-precise-histopathological-assessment
#6
Yui Jennifer Kimura, Shin-Ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Yuta Kouyama, Masashi Misawa, Yuta Sato, Shingo Matsudaira, Hiromasa Oikawa, Tomokazu Hisayuki, Yuichi Mori, Toyoki Kudo, Noriyuki Ogata, Kenta Kodama, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Toshiyuki Baba, Eiji Hidaka, Fumio Ishida, Shigeharu Hamatani
BACKGROUND/AIM: Previous reports stated that pedunculated T1 colorectal carcinomas with 'head invasion' showed almost no nodal metastasis, requiring endoscopic treatment alone. However, clinically, some lesions develop nodal metastasis. We aimed to validate the necessity of distinguishing between 'pedunculated' and 'non-pedunculated' lesions, and also between 'head' and 'stalk' invasions. METHODS: Initial or additional surgery with lymph node dissection was performed in 76 pedunculated and 594 non-pedunculated cases...
2016: Digestion
https://www.readbyqxmd.com/read/27811313/endoscopic-resection-of-high-risk-t1-colorectal-carcinoma-prior-to-surgical-resection-has-no-adverse-effect-on-long-term-outcomes
#7
A Overwater, K Kessels, S G Elias, Y Backes, B W M Spanier, T C J Seerden, H J M Pullens, W H de Vos Tot Nederveen Cappel, A van den Blink, G J A Offerhaus, J van Bergeijk, M Kerkhof, J M J Geesing, J N Groen, N van Lelyveld, F Ter Borg, F Wolfhagen, P D Siersema, M M Lacle, L M G Moons
OBJECTIVE: It is difficult to predict the presence of histological risk factors for lymph node metastasis (LNM) before endoscopic treatment of T1 colorectal cancer (CRC). Therefore, endoscopic therapy is propagated to obtain adequate histological staging. We examined whether secondary surgery following endoscopic resection of high-risk T1 CRC does not have a negative effect on patients' outcomes compared with primary surgery. DESIGN: Patients with T1 CRC with one or more histological risk factors for LNM (high risk) and treated with primary or secondary surgery between 2000 and 2014 in 13 hospitals were identified in the Netherlands Cancer Registry...
November 3, 2016: Gut
https://www.readbyqxmd.com/read/27770434/prediagnostic-circulating-inflammation-markers-and-endometrial-cancer-risk-in-the-prostate-lung-colorectal-and-ovarian-cancer-plco-screening-trial
#8
Britton Trabert, Ronald C Eldridge, Ruth M Pfeiffer, Meredith S Shiels, Troy J Kemp, Chantal Guillemette, Patricia Hartge, Mark E Sherman, Louise A Brinton, Amanda Black, Anil K Chaturvedi, Allan Hildesheim, Sonja I Berndt, Mahboobeh Safaeian, Ligia Pinto, Nicolas Wentzensen
Inflammation is proposed to increase risk of developing endometrial cancer, but few prospective epidemiologic studies have investigated the relationship between circulating inflammation markers and endometrial cancer risk. In a nested case-control study within the PLCO Screening Trial we measured serum levels of 64 inflammation-related biomarkers in 284 incident endometrial cancer cases and 284 matched controls. Using multivariable logistic regression inflammation markers were evaluated individually and combined into a cross-validated inflammation score...
February 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27757786/mri-can-be-used-to-assess-advanced-t-stage-colon-carcinoma-as-well-as-rectal-carcinoma
#9
Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Masahiro Yoshimura, Tomoharu Shimizu, Masaji Tani, Ryoji Kushima, Kiyoshi Murata
PURPOSE: To evaluate the feasibility of assessing advanced T-stage (T3-T4) colorectal carcinomas by correlating MRI with histopathological findings. MATERIALS AND METHODS: The study population comprised 31 patients with 32 lesions (22 colon and 10 rectal carcinomas). The relationship between the tumor and bowel layers on T2- and contrast-enhanced T1-weighted images (T2WI, CE-T1WI), bowel wall deformity, and the linear architecture of subserosal fat on T2WI scans was independently assessed by two radiologists...
December 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27738321/dietary-iron-intake-and-breast-cancer-risk-modulation-by-an-antioxidant-supplementation
#10
Abou Diallo, Mélanie Deschasaux, Valentin Partula, Paule Latino-Martel, Bernard Srour, Serge Hercberg, Pilar Galan, Philippine Fassier, Françoise Guéraud, Fabrice H Pierre, Mathilde Touvier
Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulation by an antioxidant supplementation and lipid intake. This prospective study included 4646 women from the SU.VI.MAX trial (daily low-dose antioxidants vs. placebo)...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27718049/diagnosis-of-early-colorectal-cancer-invasion-depth-by-quantitative-evaluation-of-the-basal-indentation-in-ct-colonography
#11
Mitsutoshi Miyasaka, Daisuke Tsurumaru, Yusuke Nishimuta, Yoshiki Asayama, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda
OBJECTIVE: To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)-i.e., the intestinal lateral deformity-in CT colonography (CTC). MATERIALS AND METHODS: 34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i...
December 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27713422/diagnosis-of-t1-colorectal-cancer-in-pedunculated-polyps-in-daily-clinical-practice-a-multicenter-study
#12
Yara Backes, Leon Mg Moons, Marco R Novelli, Jeroen D van Bergeijk, John N Groen, Tom Cj Seerden, Matthijs P Schwartz, Wouter H de Vos Tot Nederveen Cappel, Bernhard Wm Spanier, Joost Mj Geesing, Koen Kessels, Marjon Kerkhof, Peter D Siersema, G Johan A Offerhaus, Anya N Milne, Miangela M Lacle
T1 colorectal cancer can be mimicked by pseudo-invasion in pedunculated polyps. British guidelines are currently one of the few which recommend diagnostic confirmation of T1 colorectal cancer by a second pathologist. The aim of this study was to provide insights into the accuracy of histological diagnosis of pedunculated T1 colorectal cancer in daily clinical practice. A sample of 128 cases diagnosed as pedunculated T1 colorectal cancer between 2000 and 2014 from 10 Dutch hospitals was selected for histological review...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27676188/endoscopic-diagnosis-of-the-invasion-depth-of-t1-colorectal-carcinoma-for-endoscopic-resection-by-using-narrow-band-imaging-magnification-as-total-excisional-biopsy
#13
Makoto Sanomura, Shinji Tanaka, Yuichi Sasaki, Shinya Fukunishi, Kazuhide Higuchi
BACKGROUND/AIMS: We established a new colorectal T1 invasion depth sub-classification and evaluated it to determine whether total excisional biopsy can be performed on colorectal carcinoma (CRC) cases using narrow-band imaging (NBI) magnification. METHODS: The cases included 73 T1 carcinomas selected from 173 early CRC cases. The T1 invasion depth sub-classification was defined as follows: T1a, invasion less than 1,000 μm from the inferior border of the muscularis mucosae; T1b-1, between T1a and T1b-2; and T1b-2, T1b lesions with invasion from the deepest part of the carcinoma to within 1,000 μm of the superior border of the muscularis propria...
2016: Digestion
https://www.readbyqxmd.com/read/27644737/narrow-band-imaging-magnifying-chromoendoscopy-and-gross-morphological-features-for-the-optical-diagnosis-of-t1-colorectal-cancer-and-deep-submucosal-invasion-a-systematic-review-and-meta-analysis
#14
REVIEW
Y Backes, A Moss, J B Reitsma, P D Siersema, L M G Moons
OBJECTIVES: Optical diagnosis of T1 colorectal cancer (CRC) and T1 CRC with deep submucosal invasion is important in guiding the treatment strategy. The use of advanced imaging is not standard clinical practice in Western countries. A systematic review and meta-analysis were conducted comparing the accuracy of narrow band imaging (NBI), magnifying chromoendoscopy (MCE), and gross morphological features (GMF) seen with conventional view for the optical diagnosis of T1 CRC and deep submucosal invasion...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27644629/glutathione-s-transferase-t1-m1-and-p1-genetic-polymorphisms-and-susceptibility-to-colorectal-cancer-in-turkey
#15
Ozlem Gorukmez, Tahsin Yakut, Orhan Gorukmez, Sebnem Ozemri Sag, Ali Topak, Serdar Sahinturk, Ozkan Kanat
Colorectal cancer (CRC) is reported to be the third most common cancer worldwide and the fourth most common cause of cancer related deaths. CRC is considered to be a multifactorial disease whose risk varies due to the complex interaction between individual genetic basis and exposure to multiple endogenous factors. Glutathione S-transferases are pro-carcinogenic in CRC and are required for the conjugation between chemotherapeutics and broad spectrum xenobiotics. One hundred and eleven patients with CRC and 128 control subjects without any cancer history were enrolled in this study...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27636928/-multiple-primary-colorectal-cancer-clinical-aspects
#16
N V Soldatkina, O I Kit, Yu A Gevorkyan, A G Milakin
AIM: to define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). MATERIAL AND METHODS: The investigation was concerned with the data of 150 patients with T1-4N0-2M0-1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. RESULTS: Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27631203/the-risk-of-lymph-node-metastasis-makes-it-unsafe-to-expand-the-conventional-indications-for-endoscopic-treatment-of-t1-colorectal-cancer-a-retrospective-study-of-428-patients
#17
Bun Kim, Eun Hye Kim, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim, Hoguen Kim, Sung Pil Hong
Though endoscopic treatment is an option for T1 colorectal cancer (CRC), the optimal indications and long-term outcomes of this strategy need to be validated. Therefore, the aim of this study is to investigate long-term outcomes of endoscopy versus surgery and optimal indications for endoscopic treatment of T1 CRC.This retrospective study included 428 T1 CRC patients treated with initial endoscopy (n = 224) or surgery (n = 204) at Severance Hospital between 2005 and 2012. Patients were subdivided into 4 groups according to conventional indications (CIs) for endoscopic treatment: negative lateral/vertical margins; submucosal invasion depth within 1000 μm; no lymphovascular invasion (LVI); well or moderately differentiated...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27611610/multicenter-stratified-comparison-of-hospital-costs-between-laparoscopic-and-open-colorectal-cancer-resections-influence-of-tumor-location-and-operative-risk
#18
Johannes A Govaert, Marta Fiocco, Wouter A van Dijk, Nikki E Kolfschoten, Hubert A Prins, Jan-Willem T Dekker, Rob A E M Tollenaar, Pieter J Tanis, Michel W J M Wouters
OBJECTIVE: To compare actual 90-day hospital costs between elective open and laparoscopic colon and rectal cancer resection in a daily practice multicenter setting stratified for operative risk. BACKGROUND: Laparoscopic resection has developed as a commonly accepted surgical procedure for colorectal cancer. There are conflicting data on the influence of laparoscopy on hospital costs, without separate analyses based on operative risk. METHODS: Retrospective analyses using a population-based database (Dutch Surgical Colorectal Audit)...
September 8, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27609703/long-term-recurrence-free-survival-after-standard-endoscopic-resection-versus-surgical-resection-of-submucosal-invasive-colorectal-cancer-a-population-based-study
#19
Tim D G Belderbos, Felice N van Erning, Ignace H J T de Hingh, Martijn G H van Oijen, Valery E P P Lemmens, Peter D Siersema
BACKGROUND & AIMS: There is controversy over the optimal management for T1 colorectal cancer (T1 CRC). This study compared initial endoscopic resection with or without additional surgery, or initial surgery for T1 CRC, and assessed risk factors for lymph node metastases (LNMs) and long-term recurrence. METHODS: We performed a registration study that included all patients diagnosed with T1 CRC from 1995 through 2011 in the southeast area of The Netherlands (n = 1315)...
September 5, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27601171/small-colorectal-cancers-resembling-submucosal-tumor-with-massive-submucosal-invasion-and-lymph-node-metastasis-a-report-of-two-cases-and-review-of-the-literature
#20
Takahide Shinagawa, Soichiro Ishihara, Hiroaki Nozawa, Koji Murono, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hironori Yamaguchi, Akimasa Hayashi, Mariko Tanaka, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723)...
September 2, 2016: Clinics and Research in Hepatology and Gastroenterology
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