Read by QxMD icon Read

t1 colorectal

Britton Trabert, Ronald C Eldridge, Ruth M Pfeiffer, Meredith S Shiels, Troy J Kemp, Chantal Guillemette, Patricia Hartge, Mark E Sherman, Louise A Brinton, Amanda Black, Anil K Chaturvedi, Allan Hildesheim, Sonja I Berndt, Mahboobeh Safaeian, Ligia Pinto, Nicolas Wentzensen
Inflammation is proposed to increase risk of developing endometrial cancer, but few prospective epidemiologic studies have investigated the relationship between circulating inflammation markers and endometrial cancer risk. In a nested case-control study within the PLCO Screening Trial we measured serum levels of 64 inflammation-related biomarkers in 284 incident endometrial cancer cases and 284 matched controls. Using multivariable logistic regression inflammation markers were evaluated individually and combined into a cross-validated inflammation score...
October 22, 2016: International Journal of Cancer. Journal International du Cancer
Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Masahiro Yoshimura, Tomoharu Shimizu, Masaji Tani, Ryoji Kushima, Kiyoshi Murata
PURPOSE: To evaluate the feasibility of assessing advanced T-stage (T3-T4) colorectal carcinomas by correlating MRI with histopathological findings. MATERIALS AND METHODS: The study population comprised 31 patients with 32 lesions (22 colon and 10 rectal carcinomas). The relationship between the tumor and bowel layers on T2- and contrast-enhanced T1-weighted images (T2WI, CE-T1WI), bowel wall deformity, and the linear architecture of subserosal fat on T2WI scans was independently assessed by two radiologists...
October 18, 2016: Japanese Journal of Radiology
Abou Diallo, Mélanie Deschasaux, Valentin Partula, Paule Latino-Martel, Bernard Srour, Serge Hercberg, Pilar Galan, Philippine Fassier, Françoise Guéraud, Fabrice H Pierre, Mathilde Touvier
Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulation by an antioxidant supplementation and lipid intake. This prospective study included 4646 women from the SU.VI.MAX trial (daily low-dose antioxidants vs. placebo)...
October 12, 2016: Oncotarget
Mitsutoshi Miyasaka, Daisuke Tsurumaru, Yusuke Nishimuta, Yoshiki Asayama, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda
OBJECTIVE: To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)-i.e., the intestinal lateral deformity-in CT colonography (CTC). MATERIALS AND METHODS: 34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i...
October 7, 2016: Japanese Journal of Radiology
Yara Backes, Leon Mg Moons, Marco R Novelli, Jeroen D van Bergeijk, John N Groen, Tom Cj Seerden, Matthijs P Schwartz, Wouter H de Vos Tot Nederveen Cappel, Bernhard Wm Spanier, Joost Mj Geesing, Koen Kessels, Marjon Kerkhof, Peter D Siersema, G Johan A Offerhaus, Anya N Milne, Miangela M Lacle
T1 colorectal cancer can be mimicked by pseudo-invasion in pedunculated polyps. British guidelines are currently one of the few which recommend diagnostic confirmation of T1 colorectal cancer by a second pathologist. The aim of this study was to provide insights into the accuracy of histological diagnosis of pedunculated T1 colorectal cancer in daily clinical practice. A sample of 128 cases diagnosed as pedunculated T1 colorectal cancer between 2000 and 2014 from 10 Dutch hospitals was selected for histological review...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Makoto Sanomura, Shinji Tanaka, Yuichi Sasaki, Shinya Fukunishi, Kazuhide Higuchi
BACKGROUND/AIMS: We established a new colorectal T1 invasion depth sub-classification and evaluated it to determine whether total excisional biopsy can be performed on colorectal carcinoma (CRC) cases using narrow-band imaging (NBI) magnification. METHODS: The cases included 73 T1 carcinomas selected from 173 early CRC cases. The T1 invasion depth sub-classification was defined as follows: T1a, invasion less than 1,000 μm from the inferior border of the muscularis mucosae; T1b-1, between T1a and T1b-2; and T1b-2, T1b lesions with invasion from the deepest part of the carcinoma to within 1,000 μm of the superior border of the muscularis propria...
September 28, 2016: Digestion
Y Backes, A Moss, J B Reitsma, P D Siersema, L M G Moons
OBJECTIVES: Optical diagnosis of T1 colorectal cancer (CRC) and T1 CRC with deep submucosal invasion is important in guiding the treatment strategy. The use of advanced imaging is not standard clinical practice in Western countries. A systematic review and meta-analysis were conducted comparing the accuracy of narrow band imaging (NBI), magnifying chromoendoscopy (MCE), and gross morphological features (GMF) seen with conventional view for the optical diagnosis of T1 CRC and deep submucosal invasion...
September 20, 2016: American Journal of Gastroenterology
Ozlem Gorukmez, Tahsin Yakut, Orhan Gorukmez, Sebnem Ozemri Sag, Ali Topak, Serdar Sahinturk, Ozkan Kanat
Colorectal cancer (CRC) is reported to be the third most common cancer worldwide and the fourth most common cause of cancer related deaths. CRC is considered to be a multifactorial disease whose risk varies due to the complex interaction between individual genetic basis and exposure to multiple endogenous factors. Glutathione S-transferases are pro-carcinogenic in CRC and are required for the conjugation between chemotherapeutics and broad spectrum xenobiotics. One hundred and eleven patients with CRC and 128 control subjects without any cancer history were enrolled in this study...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
N V Soldatkina, O I Kit, Yu A Gevorkyan, A G Milakin
AIM: to define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). MATERIAL AND METHODS: The investigation was concerned with the data of 150 patients with T1-4N0-2M0-1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. RESULTS: Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63...
2016: Terapevticheskiĭ Arkhiv
Bun Kim, Eun Hye Kim, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim, Hoguen Kim, Sung Pil Hong
Though endoscopic treatment is an option for T1 colorectal cancer (CRC), the optimal indications and long-term outcomes of this strategy need to be validated. Therefore, the aim of this study is to investigate long-term outcomes of endoscopy versus surgery and optimal indications for endoscopic treatment of T1 CRC.This retrospective study included 428 T1 CRC patients treated with initial endoscopy (n = 224) or surgery (n = 204) at Severance Hospital between 2005 and 2012. Patients were subdivided into 4 groups according to conventional indications (CIs) for endoscopic treatment: negative lateral/vertical margins; submucosal invasion depth within 1000 μm; no lymphovascular invasion (LVI); well or moderately differentiated...
September 2016: Medicine (Baltimore)
Johannes A Govaert, Marta Fiocco, Wouter A van Dijk, Nikki E Kolfschoten, Hubert A Prins, Jan-Willem T Dekker, Rob A E M Tollenaar, Pieter J Tanis, Michel W J M Wouters
OBJECTIVE: To compare actual 90-day hospital costs between elective open and laparoscopic colon and rectal cancer resection in a daily practice multicenter setting stratified for operative risk. BACKGROUND: Laparoscopic resection has developed as a commonly accepted surgical procedure for colorectal cancer. There are conflicting data on the influence of laparoscopy on hospital costs, without separate analyses based on operative risk. METHODS: Retrospective analyses using a population-based database (Dutch Surgical Colorectal Audit)...
September 8, 2016: Annals of Surgery
Tim D G Belderbos, Felice N van Erning, Ignace H J T de Hingh, Martijn G H van Oijen, Valery E P P Lemmens, Peter D Siersema
BACKGROUND & AIMS: There is controversy over the optimal management for T1 colorectal cancer (T1 CRC). This study compared initial endoscopic resection with or without additional surgery, or initial surgery for T1 CRC, and assessed risk factors for lymph node metastases (LNMs) and long-term recurrence. METHODS: We performed a registration study that included all patients diagnosed with T1 CRC from 1995 through 2011 in the southeast area of The Netherlands (n = 1315)...
September 5, 2016: Clinical Gastroenterology and Hepatology
Takahide Shinagawa, Soichiro Ishihara, Hiroaki Nozawa, Koji Murono, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hironori Yamaguchi, Akimasa Hayashi, Mariko Tanaka, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723)...
September 2, 2016: Clinics and Research in Hepatology and Gastroenterology
Eisar Al-Sukhni, Kristopher Attwood, Emmanuel M Gabriel, Charles M Levea, Kazunori Kanehira, Steven J Nurkin
BACKGROUND: Lymphovascular and perineural invasion (LVI and PNI) are associated with poor outcomes in several cancers. We sought to identify clinical variables associated with LVI and PNI in colorectal cancer (CRC) and to determine their impact on survival. METHODS: A retrospective review was performed of the National Cancer Data Base (NCDB), 2004-2011. Patients with CRC and a documented LVI or PNI status were included. Multivariate analysis was conducted to examine the associations between clinical variables and LVI/PNI, PNI and survival, and LVI/PNI and lymph node (LN) status in patients with T1 and T2 tumors...
September 3, 2016: International Journal of Surgery
Edwin E G W Ter Voert, Linda Heijmen, Cornelis J A Punt, Johannes H W de Wilt, Hanneke W M van Laarhoven, Arend Heerschap
The purpose of this work was to improve dynamic contrast enhanced MRI (DCE-MRI) of liver lesions by removing motion corrupted images as identified by a structural similarity (SSIM) algorithm, and to assess the effect of this correction on the pharmacokinetic parameter K(trans) using automatically determined arterial input functions (AIFs). Fifteen patients with colorectal liver metastases were measured twice with a T1 weighted multislice 2D FLASH sequence for DCE-MRI (time resolution 1.2 s). AIFs were automatically derived from contrast inflow in the aorta of each patient...
November 2016: NMR in Biomedicine
Aldona Mularczyk, Maciej Gonciarz
UNLABELLED: The carcinogenesis of colorectal cancer involves many factors, which modify the functioning of cells and can include prostaglandins. Resection of tumours and/or radiotherapy provide potentially curative therapy for cancer of the rectum. AIM: The aim of the study was to asses the effects of neoadiuvant teleradiotherapy on PGE2 concentrations in the serum and in the resected bowel tissue as well as on COX-2 gene expression in patients with rectal cancer...
August 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Aldona Mularczyk, Maciej Gonciarz
UNLABELLED: The carcinogenesis of colorectal cancer involves many factors, which modify the functioning of cells and can include prostaglandins. Resection of tumours and/or radiotherapy provide potentially curative therapy for cancer of the rectum. AIM: The aim of the study was to asses the effects of neoadiuvant teleradiotherapy on PGE2 concentrations in the serum and in the resected bowel tissue as well as on COX-2 gene expression in patients with rectal cancer...
July 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Yuichi Mori, Shin-Ei Kudo, Shungo Endo, Chiyo Maeda, Shumpei Mukai, Yasuharu Maeda, Shinichi Kataoka, Kenichi Takeda, Katsuro Ichimasa, Hideyuki Miyachi, Naruhiko Sawada, Eiji Hidaka, Fumio Ishida
Currently, depressed type T1 colorectal cancer is often detected and its malignant potential is being revealed. However, few reports have focused on the morphology of T2 colorectal cancer types. The aim of the present retrospective study was to clarify the characteristics of colorectal T2 cancer types derived from depressed type T1 cancer. The present study included 195 patients with colorectal T2 cancer surgically resected at a referral hospital between April 2001 and April 2009. A total of 48 lesions (25%) with lymph node metastasis and 4 (2%) with distant metastasis were found...
September 2016: Molecular and Clinical Oncology
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Hejun Zhang, Kaida Ji, Jun Huang, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
This prospective study sought to investigate the prediction of preoperative metabolic syndrome and its components for the risk of colorectal cancer (CRC) mortality by analyzing a subset of data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. In total, 1,318 CRC patients who received radical resection were consecutively enrolled between January 2000 and December 2008. The median follow-up time was 58.6 months, with 412 deaths from CRC. The CRC patients with metabolic syndrome had significantly shorter median survival time (MST) than those without (50...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
Manon van der Vlugt, Sascha Corrie van Doorn, Junfeng Wang, Barbara Aj Bastiaansen, Lowewijk Aa Brosens, Paul Fockens, Evelien Dekker
BACKGROUND AND STUDY AIMS: As colorectal cancer screening programs are being implemented worldwide, an increasing number of early (T1) cancers are being diagnosed. These cancers should be recognized during colonoscopy because they require a specific therapeutic approach. Several studies have shown that Asian experts can reliably recognize T1 cancers during colonoscopy. In daily practice, however, accurate endoscopic diagnosis of T1 cancers still seems challenging. We evaluated the performance of optical diagnosis of T1 cancers by European colonoscopy experts, general gastroenterologists and gastrointestinal fellows...
July 2016: Endoscopy International Open
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"