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https://www.readbyqxmd.com/read/29792679/a-nanozyme-and-ambient-light-based-smartphone-platform-for-simultaneous-detection-of-dual-biomarkers-from-exposure-to-organophosphorus-pesticides
#1
Yuting Zhao, Mingming Yang, Qiangqiang Fu, Hui Ouyang, Wei Wen, Yang Song, Chengzhou Zhu, Yuehe Lin, Dan Du
A transparent, lateral-flow test strip coupled with a smartphone-based ambient light sensor was first proposed for detect-ing enzymatic inhibition and phosphorylation. The principle of the platform is based on the simultaneous measurement of the total amount of the enzyme and enzyme activity to biomonitor exposure to organophosphorus (OP) pesticides. In this study, butyrylcholinesterase (BChE) was adopted as the model enzyme and ethyl paraoxon was chosen as an analyte representing OP pesticides. The total amount of BChE was quantified by a sensitive colorimetric signal originating from a sandwich immunochromatographic assay utilizing PtPd nanoparticles as a polyphenol oxidase-mimicking probe, which provided a higher sensitivity than that of a peroxidase-like probe...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792326/common-principles-of-molecular-electronics-and-nanoscale-electrochemistry
#2
Paulo Roberto Bueno
The merging of nanoscale electronics and electrochemistry can potentially modernize the way electronic devices are currently engineered or constructed. It is well known that the greatest challenges will involve not only miniaturizing and improving the performance of mobile devices, but also manufacturing reliable electrical vehicles, and engineering more efficient solar panels and energy storage systems. These are just a few examples of how technological innovation is dependent on both electrochemical and electronic elements...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791713/the-transradial-approach-for-lower-extremity-vascular-intervention
#3
Rami O Tadros, Vivek S Prakash, Melissa J Baldwin, Adam Korayem, Michael L Marin, Peter L Faries
Simultaneous technological advancements in both imaging as well as devices have resulted in an expansion of endovascular options for vascular access. In particular, radial access has traditionally been more favored for coronary interventions; its use in the aortoiliac and lower extremity vasculature has been constrained by the length of devices and the size of sheaths required. However, with increasing catheter shaft lengths, in addition to new thin-walled sheaths allowing for downsizing, the ability to perform transradial interventions on infrainguinal and infrageniculate vessels has been more readily facilitated...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791260/assessment-of-the-power-required-for-optimal-use-of-current-inhalation-devices
#4
Gerhard Pohlmann, Jens M Hohlfeld, Peter Haidl, Jelena Pankalla, Rolf Michael Cloes
BACKGROUND: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a clear overview on performance requirements of standard inhalation devices that should be met by the patient's breathing power and to develop a new method to measure the individual performance data. MATERIALS AND METHODS: An optimum and still acceptable required breathing power (P in watts) was calculated for each device with the aid of individual device flow rates (determined by a literature search) and the flow resistances (by measuring the pressure drop over the different inhalation devices)...
May 23, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29791243/amcp-partnership-forum-managing-care-in-the-wave-of-precision-medicine
#5
(no author information available yet)
Precision medicine, the customization of health care to an individual's genetic profile while accounting for biomarkers and lifestyle, has increasingly been adopted by health care stakeholders to guide the development of treatment options, improve treatment decision making, provide more patient-centered care, and better inform coverage and reimbursement decisions. Despite these benefits, key challenges prevent its broader use and adoption. On December 7-8, 2017, the Academy of Managed Care Pharmacy convened a group of stakeholders to discuss these challenges and provide recommendations to facilitate broader adoption and use of precision medicine across health care settings...
May 23, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29790793/increased-arterial-stiffness-similar-findings-in-patients-with-inflammatory-bowel-disease-without-prior-hypertension-or-diabetes-and-in-patients-with-well-controlled-hypertension
#6
Radovan Prijić, Vedran Premužić, Marko Brinar, Željko Krznarić, Bojan Jelaković, Silvija Čuković-Čavka
PURPOSE: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. MATERIALS AND METHODS: A total of 89 inflammatory bowel disease patients (60 patients with Crohn's disease and 29 patients with ulcerative colitis, age range 20-64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25-69 years, 41 (56...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790741/entrapment-of-prostate-cancer-circulating-tumor-cells-with-a-sequential-size-based-microfluidic-chip
#7
Xiang Ren, Brittni Foster, Parham Ghassemi, Jeannine S Strobl, Bethany A Kerr, Masoud Agah
Circulating tumor cells (CTCs) are broadly accepted as an indicator for early cancer diagnosis and disease severity. However, there is currently no reliable method available to capture and enumerate all CTCs as most systems require either an initial CTC isolation or antibody-based capture for CTC enumeration. Many size-based CTC detection and isolation microfluidic platforms were presented in the past few years. Here we describe a new size-based, multiple-row cancer cell entrapment device that captured LNCaP-C4-2 prostate cancer cells with >95% efficiency when in spiked mouse whole blood at ~50 cells/mL...
May 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29790724/neuroprotection-in-traumatic-brain-injury
#8
Masoom Desai, Abhi Jain
PURPOSE: Traumatic brain injury has a high incidence worldwide and is associated with significant morbidity and mortality. Moreover, TBI has enduring implications in several domains and limits overall quality of life even in the survivors. Neuroprotective strategies are needed to limit morbidity and mortality associated with this disease process. Insight into the failure of these strategies is required to pursue future research successfully. BACKGROUND: Several different approaches involving pharmacological, surgical and usage of certain devices have been attempted in traumatic brain injury...
May 22, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29790719/less-is-more-as-less-as-reasonably-achievable-stenting-alaras-strategy-in-the-femoropopliteal-area
#9
Koen Deloose, Joren Callaert
BACKGROUND: Although evidence supports that the performance of drug coated balloons seems to be lesion complexity independent, it is quite clear that in long lesions, severe calcified lesions and chronic total occlusions, the bail out stent ratio is very high and that the "leaving nothing behind" strategy remains a dream in a lot of our daily cases. On the other side of the spectrum, "full metal jackets" of nitinol stents are creating even more problems. Stent fractures, intimal hyperplasia and reintervention difficulties complicate the recurrent vascular disease treatment...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790670/reference-equations-for-the-interpretation-of-forced-expiratory-and-plethysmographic-measurements-in-infants
#10
Zihang Lu, Rachel E Foong, Krzysztof Kowalik, Theo J Moraes, Aimee Dubeau, Diana Lefebvre, Stephanie D Davis, Susan Balkovec, Allan Becker, Piush Mandhane, Stuart E Turvey, Wendy Lou, Malcolm R Sears, Felix Ratjen, Padmaja Subbarao
BACKGROUND: Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equations were similar to forced flow measures and plethysmographic infant pulmonary function testing data collected in the Canadian Healthy Infant Longitudinal Development (CHILD) Study...
May 23, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29790612/split-axilla-comparison-study-of-0-5-mhz-invasive-bipolar-radiofrequency-treatment-using-insulated-microneedle-electrodes-for-primary-axillary-hyperhidrosis
#11
S B Cho, J Park, Z Zheng, K H Yoo, H Kim
BACKGROUND: Energy-delivering devices can be used to induce thermal coagulation of the eccrine sweat glands for treating primary axillary hyperhidrosis (PAH). OBJECTIVE: The objective of this study was to compare the efficacy and safety of invasive, bipolar radiofrequency (RF) treatment for PAH. METHODS: A split-axilla study was performed to compare the clinical outcomes of 0.5 MHz, invasive, bipolar RF treatment with treatment settings of a longer conduction time and lower power (LC/LP) vs a shorter conduction time and higher power (SC/HP) for treating PAH...
May 23, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29790104/beneficial-effects-of-antioxidant-furfuryl-palmitate-in-non-pharmacologic-treatments-prescription-emollient-devices-peds-for-atopic-dermatitis-and-related-skin-disorders
#12
REVIEW
Paolo Daniele Pigatto, Marco Diani
INTRODUCTION: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. The aim of this review was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, and furfuryl derivatives. METHODS: A PubMed/Google Scholar search was conducted using the term "furfuryl palmitate" (and its derivatives, including AR-GG27® ) combined with "skin," "atopic dermatitis," and "atopic eczema...
May 22, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29789641/diurnal-blood-pressure-changes
#13
REVIEW
Kei Asayama, Michihiro Satoh, Masahiro Kikuya
The definition of diurnal blood pressure changes varies widely, which can be confusing. Short-term blood pressure variability during a 24-h period and the dipping status of diurnal blood pressure can be captured by ambulatory blood pressure monitoring, and these metrics are reported to have prognostic significance for cardiovascular complications. Morning blood pressure surge also indicates this risk, but its effect may be limited to populations with specific conditions. Meanwhile, the combined use of conventional office blood pressure and out-of-office blood pressure allows us to identify people with white-coat and masked hypertension...
May 23, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29789461/co-morbidities-as-predictors-of-airflow-limitation-among-smokers-in-england
#14
Reem Kayyali, Yusur Hassan, Iman Hesso, Roshan Siva
The prevalence of co-morbidities among patients with Chronic Obstructive Pulmonary Disease (COPD) is well documented in the literature. Therefore, this pilot study aimed to identify whether co-morbidities screening would enhance COPD case-finding. Smoking patients were approached at Croydon University Hospital and two local community pharmacies (CPs). Their co-morbidities, respiratory symptoms, smoking pack-years and exercise capacity were collected. Airflow limitation was determined using handheld spirometry (COPD-6) device...
May 22, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29789238/a-phase-1-study-of-safety-and-immunogenicity-following-intradermal-administration-of-a-tetravalent-dengue-vaccine-candidate
#15
Lisa A Jackson, Richard Rupp, Athanasia Papadimitriou, Derek Wallace, Marsha Raanan, Kelley J Moss
BACKGROUND: As part of the ongoing search for an effective dengue vaccine, Takeda performed a phase 1b study to investigate the safety and immunogenicity of an early low-dose tetravalent dengue vaccine candidate formulation (LD-TDV), based on an attenuated serotype 2 backbone, when administered intradermally with an injector device (PharmaJet®), or needle-syringe. METHODS: The study was performed in two centers in the US, in healthy 18-45 year old subjects with no history of dengue vaccination or disease...
May 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29788224/iron-sequestration-in-microbiota-biofilms-as-a-novel-strategy-for-treating-inflammatory-bowel-disease
#16
Jean-Paul Motta, Thibault Allain, Luke E Green-Harrison, Ryan A Groves, Troy Feener, Hena Ramay, Paul L Beck, Ian A Lewis, John L Wallace, Andre G Buret
Significant alterations of intestinal microbiota and anemia are hallmarks of inflammatory bowel disease (IBD). It is widely accepted that iron is a key nutrient for pathogenic bacteria, but little is known about its impact on microbiota associated with IBD. We used a model device to grow human mucosa-associated microbiota in its physiological anaerobic biofilm phenotype. Compared to microbiota from healthy donors, microbiota from IBD patients generate biofilms ex vivo that were larger in size and cell numbers, contained higher intracellular iron concentrations, and exhibited heightened virulence in a model of human intestinal epithelia in vitro and in the nematode Caenorhabditis elegans...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787873/transforaminal-endoscopic-decompression-for-foot-drop-twelve-years-after-lumbar-total-disc-replacment-technical-note
#17
Albert E Telfeian, Adetokunbo Oyelese, Jared Fridley, Ziya L Gokaslan
Lumbar total disc replacement (LTDR) is considered for the treatment of lumbar degenerative disc disease with the hope that by preserving motion the long-term fusion complication of adjacent segment disease can be avoided. The complications of LTDR can be divided into approach-related and long-term complications. Very little has been described about the complications and treatment for complications more than 10 years after the device has been implanted. Here we describe a tranforaminal endoscopic discectomy procedure for a patient presenting with foot drop twelve years after a L5-S1 total disc replacement...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787037/effects-of-perinatal-exposure-to-dibutyltin-chloride-on-fat-and-glucose-metabolism-in-mice-and-molecular-mechanisms-in-vitro
#18
Raquel Chamorro-García, Bassem M Shoucri, Sigal Willner, Heidi Käch, Amanda Janesick, Bruce Blumberg
BACKGROUND: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT during in utero development at relatively high doses, but little was known about the effects of DBT exposure at environmentally relevant doses on endpoints such as obesity and metabolic disease. OBJECTIVES: We tested the potential obesogenic effects of DBT using in vitro and in vivo models...
May 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29786781/the-ejes-3d-tool-for-personalized-prescription-of-exercise-in-axial-spondyloarthritis-through-multimedia-animations-pilot-study
#19
Mariano Tomás Flórez, Raquel Almodóvar, Fernando García Pérez, Ana Belén Rodríguez Cambrón, Loreto Carmona, María Ángeles Pérez Manzanero, Juan Aboitiz Cantalapiedra, Ana Urruticoechea-Arana, Carlos J Rodríguez Lozano, Carmen Castro, Cristina Fernández-Carballido, Eugenio de Miguel, Eva Galíndez, José Luis Álvarez Vega, Juan Carlos Torre Alonso, Luis F Linares, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Pedro Zarco
To develop and evaluate a web application based on multimedia animations, combined with a training program, to improve the prescription of exercises in spondyloarthritis (SpA). After a review of exercises included in the main clinical trials and recommendations of international societies, a multidisciplinary team-rehabilitators, rheumatologists, physiotherapists, computer scientists and graphic designers-developed a web application for the prescription of exercises (EJES-3D). Once completed, this was presented to 12 pairs of rehabilitators-rheumatologists from the same hospital in a workshop...
May 21, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29786679/-the-rationale-for-the-application-of-photomagnetic-therapy-in-the-treatment-of-dermatitis
#20
N I Schastnaya, V S Ulashchyk
BACKGROUND: in spite of the fact that photomagnetic therapy with the use of the FotoSPOK device (Magnomed Ltd., Belarus) is already used in the medical practice, the application of this method for the management of many diseases remains to be substantiated on the scientifically sound grounds. AIM: The objective of the present study was to evaluate the effectiveness of photomagnetic therapy in the treatment of the local inflammatory process in the skin and to elaborate the rationale for the application of this technique in the treatment of contact dermatitis...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
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