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https://www.readbyqxmd.com/read/24524923/the-diagnosis-of-multiple-sclerosis-and-the-various-related-demyelinating-syndromes-a-critical-review
#1
REVIEW
Dimitrios Karussis
Multiple sclerosis (MS), is a chronic disease of the central nervous system (CNS) characterized by loss of motor and sensory function, that results from immune-mediated inflammation, demyelination and subsequent axonal damage. MS is one of the most common causes of neurological disability in young adults. Several variants of MS (and CNS demyelinating syndromes in general) have been nowadays defined in an effort to increase the diagnostic accuracy, to identify the unique immunopathogenic profile and to tailor treatment in each individual patient...
February 2014: Journal of Autoimmunity
https://www.readbyqxmd.com/read/24514081/the-spectrum-of-post-vaccination-inflammatory-cns-demyelinating-syndromes
#2
REVIEW
Dimitrios Karussis, Panayiota Petrou
A wide variety of inflammatory diseases temporally associated with the administration of various vaccines, has been reported in the literature. A PubMed search from 1979 to 2013 revealed seventy one (71) documented cases. The most commonly reported vaccinations that were associated with CNS demyelinating diseases included influenza (21 cases), human papilloma virus (HPV) (9 cases), hepatitis A or B (8 cases), rabies (5 cases), measles (5 cases), rubella (5 cases), yellow fever (3 cases), anthrax (2 cases),meningococcus (2 cases) and tetanus (2 cases)...
March 2014: Autoimmunity Reviews
https://www.readbyqxmd.com/read/15727225/lessons-from-the-neuropathology-of-atypical-forms-of-multiple-sclerosis
#3
REVIEW
C Stadelmann, W Brück
Multiple sclerosis (MS) is characterized by multiple demyelinated inflammatory lesions disseminated in the central nervous system (CNS). Additional features of MS pathology include axonal loss and gliosis. Remyelination may take place predominantly in the early stages of lesion formation. Pathologically, important inter-individual differences have been observed with respect to oligodendrocyte preservation. Furthermore, different mechanisms of demyelination, such as T-cell/macrophage-mediated demyelination, antibody/complement-mediated demyelination, and primary damage of the oligodendrocyte have been observed in individual MS patients...
November 2004: Neurological Sciences
https://www.readbyqxmd.com/read/9778261/a-subgroup-of-multiple-sclerosis-patients-with-anticardiolipin-antibodies-and-unusual-clinical-manifestations-do-they-represent-a-new-nosological-entity
#4
D Karussis, R R Leker, A Ashkenazi, O Abramsky
The presence of antibodies to cardiolipin (ACL Abs) has been reported in some patients suffering from multiple sclerosis (MS), especially of the "neuromyelitic" type. In addition, bright T2-imaging foci (unidentified bright objects) are occasionally detected on brain magnetic resonance imaging (MRI) scans, in patients with antiphospholipid syndrome. From a cohort of 100 patients with a probable or definite diagnosis of MS according to Poser's criteria, we isolated a subgroup of 20 patients (8 males and 12 females) consistently positive for ACL Abs...
October 1998: Annals of Neurology
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