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https://www.readbyqxmd.com/read/29345207/thresholds-and-interpretations-how-clinical-competency-committees-identify-pediatric-residents-with-performance-concerns
#1
Daniel J Schumacher, Catherine Michelson, Sue Poynter, Michelle M Barnes, Su-Ting T Li, Natalie Burman, Daniel J Sklansky, Lynn Thoreson, Sharon Calaman, Beth King, Alan Schwartz, Sean Elliott, Tanvi Sharma, Javier Gonzalez Del Rey, Kathleen Bartlett, Shannon E Scott-Vernaglia, Kathleen Gibbs, Jon F McGreevy, Lynn C Garfunkel, Caren Gellin, John G Frohna
BACKGROUND: Clinical competency committee (CCC) identification of residents with performance concerns is critical for early intervention. METHODS: Program directors and 94 CCC members at 14 pediatric residency programs responded to a written survey prompt asking them to describe how they identify residents with performance concerns. Data was analyzed using thematic analysis. RESULTS: Six themes emerged from analysis and were grouped into two domains...
January 2018: Medical Teacher
https://www.readbyqxmd.com/read/29344318/noninvasive-long-term-monitoring-of-actinic-keratosis-and-field-cancerization-following-treatment-with-ingenol-mebutate-gel-0-015
#2
Orit Markowitz, Katie Wang, Amanda Levine, Michelle Schwartz, Sumeet Minhas, Eleanor Feldman, Daniel M Siegel
OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. SETTING: An outpatient clinic. PARTICIPANTS: Fifteen of the original 28 study patients enrolled in and who completed the extension phase...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29328686/three-dimensional-tracking-of-interfacial-hopping-diffusion
#3
Dapeng Wang, Haichao Wu, Daniel K Schwartz
Theoretical predictions have suggested that molecular motion at interfaces-which influences processes including heterogeneous catalysis, (bio)chemical sensing, lubrication and adhesion, and nanomaterial self-assembly-may be dominated by hypothetical "hops" through the adjacent liquid phase, where a diffusing molecule readsorbs after a given hop according to a probabilistic "sticking coefficient." Here, we use three-dimensional (3D) single-molecule tracking to explicitly visualize this process for human serum albumin at solid-liquid interfaces that exert varying electrostatic interactions on the biomacromolecule...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29317407/a20-haploinsufficiency-ha20-clinical-phenotypes-and-disease-course-of-patients-with-a-newly-recognised-nf-kb-mediated-autoinflammatory-disease
#4
Florence A Aeschlimann, Ezgi D Batu, Scott W Canna, Ellen Go, Ahmet Gül, Patrycja Hoffmann, Helen L Leavis, Seza Ozen, Daniella M Schwartz, Deborah L Stone, Annet van Royen-Kerkof, Daniel L Kastner, Ivona Aksentijevich, Ronald M Laxer
OBJECTIVES: The association between mutations in TNFAIP3, encoding the NF-kB regulatory protein A20, and a new autoinflammatory disease has recently been recognised. This study aims at describing the clinical phenotypes and disease course of patients with A20 haploinsufficiency (HA20). METHODS: Data for all cases from the initial publication, and additional cases identified through collaborations since, were collected using standardised data collection forms. RESULTS: A total of 16 patients (13 female) from seven families with a genetic diagnosis of HA20 were included...
January 9, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29311653/meta-analysis-of-epigenome-wide-association-studies-of-cognitive-abilities
#5
Riccardo E Marioni, Allan F McRae, Jan Bressler, Elena Colicino, Eilis Hannon, Shuo Li, Diddier Prada, Jennifer A Smith, Letizia Trevisi, Pei-Chien Tsai, Dina Vojinovic, Jeannette Simino, Daniel Levy, Chunyu Liu, Michael Mendelson, Claudia L Satizabal, Qiong Yang, Min A Jhun, Sharon L R Kardia, Wei Zhao, Stefania Bandinelli, Luigi Ferrucci, Dena G Hernandez, Andrew B Singleton, Sarah E Harris, John M Starr, Douglas P Kiel, Robert R McLean, Allan C Just, Joel Schwartz, Avron Spiro, Pantel Vokonas, Najaf Amin, M Arfan Ikram, Andre G Uitterlinden, Joyce B J van Meurs, Tim D Spector, Claire Steves, Andrea A Baccarelli, Jordana T Bell, Cornelia M van Duijn, Myriam Fornage, Yi-Hsiang Hsu, Jonathan Mill, Thomas H Mosley, Sudha Seshadri, Ian J Deary
Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts...
January 8, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29305761/patterns-of-substance-use-and-arrest-histories-among-hospitalized-hiv-drug-users-a-latent-class-analysis
#6
Karen Shiu-Yee, Ahnalee M Brincks, Daniel J Feaster, Jemima A Frimpong, Ank Nijhawan, Raul N Mandler, Robert Schwartz, Carlos Del Rio, Lisa R Metsch
Using baseline data from the NIDA Clinical Trials Network 0049 study (Project HOPE), we performed latent class analyses (LCA) to identify discrete classes, or clusters, of people living with HIV (PLWH) based on their past year substance use behaviors and lifetime arrest history. We also performed multinomial logistic regressions to identify key characteristics associated with class membership. We identified 5 classes of substance users (minimal drug users, cocaine users, substantial cocaine/hazardous alcohol users, problem polysubstance users, substantial cocaine/heroin users) and 3 classes of arrest history (minimal arrests, non-drug arrests, drug-related arrests)...
January 5, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29304990/a-mixed-methods-study-of-symptom-perception-in-patients-with-chronic-heart-failure
#7
Barbara Riegel, Victoria Vaughan Dickson, Christopher S Lee, Marguerite Daus, Julia Hill, Elliane Irani, Solim Lee, Joyce W Wald, Stephen T Moelter, Lisa Rathman, Megan Streur, Foster Osei Baah, Linda Ruppert, Daniel R Schwartz, Alfred Bove
BACKGROUND: Early heart failure (HF) symptoms are frequently unrecognized for reasons that are unclear. We explored symptom perception in patients with chronic HF. METHODS: We enrolled 36 HF out-patients into a longitudinal sequential explanatory mixed methods study. We used objectively measured thoracic fluid accumulation and daily reports of signs and symptoms to evaluate accuracy of detected changes in fluid retention. Patterns of symptom interpretation and response were explored in telephone interviews conducted every 2 weeks for 3-months...
January 3, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29276803/projections-of-temperature-related-excess-mortality-under-climate-change-scenarios
#8
Antonio Gasparrini, Yuming Guo, Francesco Sera, Ana Maria Vicedo-Cabrera, Veronika Huber, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J K Jaakkola, Niilo R I Ryti, Mathilde Pascal, Patrick G Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Diaz, Julio Cesar Cruz, Xerxes Seposo, Ho Kim, Aurelio Tobias, Carmen Iñiguez, Bertil Forsberg, Daniel Oudin Åström, Martina S Ragettli, Yue Leon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel Schwartz, Michelle L Bell, Tran Ngoc Dang, Dung Do Van, Clare Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andy Haines, Ben Armstrong
Background: Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods: We collected observed daily time series of mean temperature and mortality counts for all causes or non-external causes only, in periods ranging from Jan 1, 1984, to Dec 31, 2015, from various locations across the globe through the Multi-Country Multi-City Collaborative Research Network...
December 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29261187/early-cancer-diagnoses-through-brca1-2-screening-of-unselected-adult-biobank-participants
#9
Adam H Buchanan, Kandamurugu Manickam, Michelle N Meyer, Jennifer K Wagner, Miranda L G Hallquist, Janet L Williams, Alanna Kulchak Rahm, Marc S Williams, Zong-Ming E Chen, Chaitali K Shah, Tullika K Garg, Amanda L Lazzeri, Marci L B Schwartz, D'Andra M Lindbuchler, Audrey L Fan, Rosemary Leeming, Pedro O Servano, Ashlee L Smith, Victor G Vogel, Noura S Abul-Husn, Frederick E Dewey, Matthew S Lebo, Heather M Mason-Suares, Marylyn D Ritchie, F Daniel Davis, David J Carey, David T Feinberg, W Andrew Faucett, David H Ledbetter, Michael F Murray
PurposeThe clinical utility of screening unselected individuals for pathogenic BRCA1/2 variants has not been established. Data on cancer risk management behaviors and diagnoses of BRCA1/2-associated cancers can help inform assessments of clinical utility.MethodsWhole-exome sequences of participants in the MyCode Community Health Initiative were reviewed for pathogenic/likely pathogenic BRCA1/2 variants. Clinically confirmed variants were disclosed to patient-participants and their clinicians. We queried patient-participants' electronic health records for BRCA1/2-associated cancer diagnoses and risk management that occurred within 12 months after results disclosure, and calculated the percentage of patient-participants of eligible age who had begun risk management...
October 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29243073/clinical-quantification-of-myocardial-blood-flow-using-pet-joint-position-paper-of-the-snmmi-cardiovascular-council-and-the-asnc
#10
Venkatesh L Murthy, Timothy M Bateman, Rob S Beanlands, Daniel S Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D Cerqueira, Robert A deKemp, E Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P Ficaro, Ernest V Garcia, Henry Gewirtz, Gary V Heller, Howard C Lewin, Saurabh Malhotra, April Mann, Terrence D Ruddy, Thomas H Schindler, Ronald G Schwartz, Piotr J Slomka, Prem Soman, Marcelo F Di Carli, Andrew Einstein, Raymond Russell, James R Corbett
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29242396/clinical-quantification-of-myocardial-blood-flow-using-pet-joint-position-paper-of-the-snmmi-cardiovascular-council-and-the-asnc
#11
Venkatesh L Murthy, Timothy M Bateman, Rob S Beanlands, Daniel S Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D Cerqueira, Robert A deKemp, E Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P Ficaro, Ernest V Garcia, Henry Gewirtz, Gary V Heller, Howard C Lewin, Saurabh Malhotra, April Mann, Terrence D Ruddy, Thomas H Schindler, Ronald G Schwartz, Piotr J Slomka, Prem Soman, Marcelo F Di Carli
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29236593/role-of-genetic-testing-for-inherited-prostate-cancer-risk-philadelphia-prostate-cancer-consensus-conference-2017
#12
Veda N Giri, Karen E Knudsen, William K Kelly, Wassim Abida, Gerald L Andriole, Chris H Bangma, Justin E Bekelman, Mitchell C Benson, Amie Blanco, Arthur Burnett, William J Catalona, Kathleen A Cooney, Matthew Cooperberg, David E Crawford, Robert B Den, Adam P Dicker, Scott Eggener, Neil Fleshner, Matthew L Freedman, Freddie C Hamdy, Jean Hoffman-Censits, Mark D Hurwitz, Colette Hyatt, William B Isaacs, Christopher J Kane, Philip Kantoff, R Jeffrey Karnes, Lawrence I Karsh, Eric A Klein, Daniel W Lin, Kevin R Loughlin, Grace Lu-Yao, S Bruce Malkowicz, Mark J Mann, James R Mark, Peter A McCue, Martin M Miner, Todd Morgan, Judd W Moul, Ronald E Myers, Sarah M Nielsen, Elias Obeid, Christian P Pavlovich, Stephen C Peiper, David F Penson, Daniel Petrylak, Curtis A Pettaway, Robert Pilarski, Peter A Pinto, Wendy Poage, Ganesh V Raj, Timothy R Rebbeck, Mark E Robson, Matt T Rosenberg, Howard Sandler, Oliver Sartor, Edward Schaeffer, Gordon F Schwartz, Mark S Shahin, Neal D Shore, Brian Shuch, Howard R Soule, Scott A Tomlins, Edouard J Trabulsi, Robert Uzzo, Donald J Vander Griend, Patrick C Walsh, Carol J Weil, Richard Wender, Leonard G Gomella
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing...
December 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29205477/quantitative-comparison-of-delayed-ferumoxytol-t1-enhancement-with-immediate-gadoteridol-enhancement-in-high-grade-gliomas
#13
Andrea Horváth, Csanad G Varallyay, Daniel Schwartz, Gerda B Toth, Joao P Netto, Ramon Barajas, Péter Várallyay, László Szidonya, Jenny Firkins, Emily Youngers, Rongwei Fu, Prakash Ambady, Péter Bogner, Edward A Neuwelt
PURPOSE: Delayed ferumoxytol enhancement on T1 -weighted images appears visually similar to gadoteridol enhancement. The purpose of this study was to quantitatively compare ferumoxytol T1 enhancement to gadoteridol enhancement with an objective, semi-automated method. METHODS: 206 sets of post-gadoteridol and 24 h post-ferumoxytol T1 -weighted scans from 58 high grade glioma patients were analyzed (9 pre-chemoradiation, 111 < 90 days post-chemoradiation, 21 > 90 days post-chemoradiation, 65 post-bevacizumab scans)...
December 4, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29198723/dna-methylation-analysis-identifies-loci-for-blood-pressure-regulation
#14
Melissa A Richard, Tianxiao Huan, Symen Ligthart, Rahul Gondalia, Min A Jhun, Jennifer A Brody, Marguerite R Irvin, Riccardo Marioni, Jincheng Shen, Pei-Chien Tsai, May E Montasser, Yucheng Jia, Catriona Syme, Elias L Salfati, Eric Boerwinkle, Weihua Guan, Thomas H Mosley, Jan Bressler, Alanna C Morrison, Chunyu Liu, Michael M Mendelson, André G Uitterlinden, Joyce B van Meurs, Oscar H Franco, Guosheng Zhang, Yun Li, James D Stewart, Joshua C Bis, Bruce M Psaty, Yii-Der Ida Chen, Sharon L R Kardia, Wei Zhao, Stephen T Turner, Devin Absher, Stella Aslibekyan, John M Starr, Allan F McRae, Lifang Hou, Allan C Just, Joel D Schwartz, Pantel S Vokonas, Cristina Menni, Tim D Spector, Alan Shuldiner, Coleen M Damcott, Jerome I Rotter, Walter Palmas, Yongmei Liu, Tomáš Paus, Steve Horvath, Jeffrey R O'Connell, Xiuqing Guo, Zdenka Pausova, Themistocles L Assimes, Nona Sotoodehnia, Jennifer A Smith, Donna K Arnett, Ian J Deary, Andrea A Baccarelli, Jordana T Bell, Eric Whitsel, Abbas Dehghan, Daniel Levy, Myriam Fornage
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry...
November 30, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29187564/a-comparison-of-aspergillus-and-mucorales-pcr-testing-of-different-bal-fractions-from-patients-with-suspected-invasive-pulmonary-fungal-disease
#15
Jan Springer, P Lewis White, Johanna Kessel, Imke Wieters, Daniel Teschner, Daniel Korczynski, Tobias Liebregts, Oliver A Cornely, Stefan Schwartz, Thomas Elgeti, Lisa Meintker, Stefan W Krause, Raquel B Posso, Werner J Heinz, Sandra Fuhrmann, Jörg Janne Vehreschild, Hermann Einsele, Volker Rickerts, Juergen Loeffler
In patients with haematological malignancies, bronchoalveolar lavage fluid specimens (BALF) are commonly used for the diagnosis of mould infections. However, it is not clear whether the cellular pellet (P) or the supernatant fraction (S) of the BALF is optimal for molecular diagnostic testing. Thus, 99 BALF specimens from 96 haematology patients with or without allogeneic hematopoietic stem cell transplant were collected. Pellets and supernatants were processed alone and in combination (S/P) by two fungal-specific real-time PCR assays compliant with international recommendations...
November 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29181861/aneuploidy-tp53-mutation-and-amplification-of-myc-correlate-with-increased-intratumor-heterogeneity-and-poor-prognosis-of-breast-cancer-patients
#16
Johanna Oltmann, Kerstin Heselmeyer-Haddad, Leanora S Hernandez, Rüdiger Meyer, Irianna Torres, Yue Hu, Natalie Doberstein, J Keith Killian, David Petersen, Y Jack Zhu, Daniel C Edelman, Paul S Meltzer, Russell Schwartz, E Michael Gertz, Alejandro A Schäffer, Gert Auer, Jens K Habermann, Thomas Ried
The clinical course of breast cancer varies from one patient to another. Currently, the choice of therapy relies on clinical parameters and histological and molecular tumor features. Alas, these markers are informative in only a subset of patients. Therefore, additional predictors of disease outcome would be valuable for treatment stratification. Extensive studies showed that the degree of variation of the nuclear DNA content, i.e., aneuploidy determines prognosis. Our aim was to further elucidate the molecular basis of aneuploidy...
November 27, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29161008/mapping-the-functional-tortuosity-and-spatio-temporal-heterogeneity-of-porous-polymer-membranes-with-super-resolution-nanoparticle-tracking
#17
Yu Cai, Daniel K Schwartz
As particles flow through porous media, they follow complex pathways and experience heterogeneous environments that are challenging to characterize. Tortuosity is often used as a parameter to characterize the complexity of pathways in porous materials and is useful in understanding hindered mass transport in industrial filtration and mass separation processes. However, conventional calculations of tortuosity provide only average values under static conditions; they are insensitive to the intrinsic heterogeneity of porous media and do not account for potential effects of operating conditions...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29123087/live-imaging-molecular-changes-in-junctional-tension-upon-ve-cadherin-in-zebrafish
#18
Anne Karine Lagendijk, Guillermo A Gomez, Sungmin Baek, Daniel Hesselson, William E Hughes, Scott Paterson, Daniel E Conway, Heinz-Georg Belting, Markus Affolter, Kelly A Smith, Martin A Schwartz, Alpha S Yap, Benjamin M Hogan
Forces play diverse roles in vascular development, homeostasis and disease. VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells, serving as a tension-transducer. To explore tensile changes across VE-cadherin in live zebrafish, we tailored an optical biosensor approach, originally established in vitro. We validate localization and function of a VE-cadherin tension sensor (TS) in vivo. Changes in tension across VE-cadherin observed using ratio-metric or lifetime FRET measurements reflect acto-myosin contractility within endothelial cells...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29106329/the-naims-cooperative-pilot-project-design-implementation-and-future-directions
#19
Jiwon Oh, Rohit Bakshi, Peter A Calabresi, Ciprian Crainiceanu, Roland G Henry, Govind Nair, Nico Papinutto, R Todd Constable, Daniel S Reich, Daniel Pelletier, William Rooney, Daniel Schwartz, Ian Tagge, Russell T Shinohara, Jack H Simon, Nancy L Sicotte
The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29090534/challenges-and-advantages-in-wide-field-optical-coherence-tomography-angiography-imaging-of-the-human-retinal-and-choroidal-vasculature-at-1-7-mhz-a-scan-rate
#20
Raju Poddar, Justin V Migacz, Daniel M Schwartz, John S Werner, Iwona Gorczynska
We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks...
October 2017: Journal of Biomedical Optics
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