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https://www.readbyqxmd.com/read/28209069/patterns-of-care-and-survival-outcomes-of-palliative-radiation-for-prostate-cancer-with-bone-metastases-comparison-of-%C3%A2-5-fractions-to-%C3%A2-10-fractions
#1
David Schreiber, Joseph Safdieh, Daniel J Becker, David Schwartz
BACKGROUND: To review the palliative radiation fractionation regimens, trends and survival of men within the National Cancer Database (NCDB) diagnosed with prostate cancer and bony metastases. METHODS: A total of 3,871 patients from the NCDB were included in the analysis (patients treated from 2004-2012). The following fractionation regimens were analyzed [8 Gy × 1, 4 Gy × 5 (short course radiation therapy)], were compared to 3 Gy × 10, 2.50 Gy × 14-15 and 2 Gy × 20-30 (long course radiation therapy)...
January 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28206778/personal-and-cultural-identity-development-in-recently-immigrated-hispanic-adolescents-links-with-psychosocial-functioning
#2
Alan Meca, Raha F Sabet, Colleen M Farrelly, Cynthia G Benitez, Seth J Schwartz, Melinda Gonzales-Backen, Elma I Lorenzo-Blanco, Jennifer B Unger, Byron L Zamboanga, Lourdes Baezconde-Garbanati, Simona Picariello, Sabrina E Des Rosiers, Daniel W Soto, Monica Pattarroyo, Juan A Villamar, Karina M Lizzi
OBJECTIVES: This study examined directionality between personal (i.e., coherence and confusion) and cultural identity (i.e., ethnic and U.S.) as well as their additive effects on psychosocial functioning in a sample of recently immigrated Hispanic adolescents. METHOD: The sample consisted of 302 recent (<5 years) immigrant Hispanic adolescents (53% boys; Mage = 14.51 years at baseline; SD = .88 years) from Miami and Los Angeles who participated in a longitudinal study...
February 16, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28196601/cholinergic-signals-from-the-cns-regulate-g-csf-mediated-hsc-mobilization-from-bone-marrow-via-a-glucocorticoid-signaling-relay
#3
Halley Pierce, Dachuan Zhang, Claire Magnon, Daniel Lucas, John R Christin, Matthew Huggins, Gary J Schwartz, Paul S Frenette
Hematopoietic stem cells (HSCs) are mobilized from niches in the bone marrow (BM) to the blood circulation by the cytokine granulocyte colony-stimulating factor (G-CSF) through complex mechanisms. Among these, signals from the sympathetic nervous system regulate HSC egress via its niche, but how the brain communicates with the BM remains largely unknown. Here we show that muscarinic receptor type-1 (Chrm1) signaling in the hypothalamus promotes G-CSF-elicited HSC mobilization via hormonal priming of the hypothalamic-pituitary-adrenal (HPA) axis...
February 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28194713/use-of-compressive-osseointegration-endoprostheses-for-massive-bone-loss-from-tumor-and-failed-arthroplasty-a-viable-option-in-the-upper-extremity
#4
Krista A Goulding, Adam Schwartz, Steven J Hattrup, R Lor Randall, Donald Lee, Damian M Rispoli, Daniel M Lerman, Christopher Beauchamp
BACKGROUND: Endoprostheses using principles of compressive osseointegration have shown good survivorship in several studies involving the lower extremity; however, no series to our knowledge have documented the use of this technology in the management of massive bone loss in the upper limb. QUESTIONS/PURPOSES: (1) What proportion of upper extremity implants using compressive osseointegration fixation principles achieved durable short-term fixation, and what were the modes of failure? (2) What surgical complications resulted from reconstruction using this technique? METHODS: A multiinstitutional retrospective review identified nine patients (five women; four men) who underwent 13 endoprosthetic replacements between 2003 and 2014 using compressive osseointegration (Compliant(®) Pre-stress Device [CPS]; Biomet Inc, Warsaw, IN, USA) in the upper extremity, including two proximal humeri, two humeral diaphyses, seven distal humeri, and two proximal ulna...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28186535/long-term-risks-of-kidney-living-donation-review-and-position-paper-by-the-era-edta-descartes-working-group
#5
Umberto Maggiore, Klemens Budde, Uwe Heemann, Luuk Hilbrands, Rainer Oberbauer, Gabriel C Oniscu, Julio Pascual, Soren Schwartz Sorensen, Ondrej Viklicky, Daniel Abramowicz
No abstract text is available yet for this article.
February 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28181493/natural-amines-inhibit-activation-of-human-plasmacytoid-dendritic-cells-through-cxcr4-engagement
#6
Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28164012/effect-of-serial-infusions-of-reconstituted-high-density-lipoprotein-cer-001-on-coronary-atherosclerosis-rationale-and-design-of-the-carat-study
#7
Jordan Andrews, Alex Janssan, Tracy Nguyen, Anthony D Pisaniello, Daniel J Scherer, John J P Kastelein, Bela Merkely, Steven E Nissen, Kausik Ray, Gregory G Schwartz, Stephen G Worthley, Connie Keyserling, Jean-Louis Dasseux, Julie Butters, Jacinta Girardi, Rosemary Miller, Stephen J Nicholls
BACKGROUND: High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS)...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28158429/elucidating-arrhythmogenic-mechanisms-of-long-qt-syndrome-calm1-f142l-mutation-in-patient-specific-induced-pluripotent-stem-cell-derived-cardiomyocytes
#8
Marcella Rocchetti, Luca Sala, Lisa Dreizehnter, Lia Crotti, Daniel Sinnecker, Manuela Mura, Luna Simona Pane, Claudia Altomare, Eleonora Torre, Gaspare Mostacciuolo, Stefano Severi, Alberto Porta, Gaetano M De Ferrari, Alfred L George, Peter J Schwartz, Massimiliano Gnecchi, Alessandra Moretti, Antonio Zaza
No abstract text is available yet for this article.
February 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28146567/differential-dna-methylation-regions-in-adult-human-sperm-following-adolescent-chemotherapy-potential-for-epigenetic-inheritance
#9
Margarett Shnorhavorian, Stephen M Schwartz, Barbara Stansfeld, Ingrid Sadler-Riggleman, Daniel Beck, Michael K Skinner
BACKGROUND: The potential that adolescent chemotherapy can impact the epigenetic programming of the germ line to influence later life adult fertility and promote epigenetic inheritance was investigated. Previous studies have demonstrated a number of environmental exposures such as abnormal nutrition and toxicants can promote sperm epigenetic changes that impact offspring. METHODS: Adult males approximately ten years after pubertal exposure to chemotherapy were compared to adult males with no previous exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28122337/prognostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-the-arq-197-215-second-line-study-for-advanced-hepatocellular-carcinoma
#10
Nicola Personeni, Laura Giordano, Giovanni Abbadessa, Camillo Porta, Ivan Borbath, Bruno Daniele, Jean-Luc Van Laethem, Hans Van Vlierberghe, Jörg Trojan, Enrico N De Toni, Antonio Gasbarrini, Monica Lencioni, Maria E Lamar, Yunxia Wang, Dale Shuster, Brian Schwartz, Armando Santoro, Lorenza Rimassa
The ARQ 197-215 study randomized patients to tivantinib or placebo and pre-specified efficacy analyses indicated the predictive value of MET expression as a marker of benefit from tivantinib in hepatocellular carcinoma (HCC). We aimed to explore the neutrophil-to-lymphocyte ratio (NLR) in 98 ARQ 197-215 patients with available absolute neutrophil count and absolute lymphocyte count at baseline. The cut-off value used to define high versus low NLR was 3.0. In univariate analysis, high NLR was associated with hazard ratio (HR) for overall survival (OS) of 1...
January 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28112506/characterizing-substrate-surface-interactions-on-alumina-supported-metal-catalysts-by-dynamic-nuclear-polarization-enhanced-double-resonance-nmr-spectroscopy
#11
Frédéric A Perras, J Daniel Padmos, Robert L Johnson, Lin-Lin Wang, Thomas J Schwartz, Takeshi Kobayashi, J Hugh Horton, James A Dumesic, Brent H Shanks, Duane D Johnson, Marek Pruski
The characterization of nanometer-scale interactions between carbon-containing substrates and alumina surfaces is of paramount importance to industrial and academic catalysis applications, but it is also very challenging. Here, we demonstrate that dynamic nuclear polarization surface-enhanced NMR spectroscopy (DNP SENS) allows the unambiguous description of the coordination geometries and conformations of the substrates at the alumina surface through high-resolution measurements of (13)C-(27)Al distances. We apply this new technique to elucidate the molecular-level geometry of (13)C-enriched methionine and natural abundance poly(vinyl alcohol) adsorbed on γ-Al2O3-supported Pd catalysts, and we support these results with element-specific X-ray absorption near-edge measurements...
February 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098509/-compassionate-use-protocol-for-auditory-brainstem-implantation-in-neurofibromatosis-type-2-early-house-ear-institute-experience
#12
Daniel S Roberts, William H Slattery, Brian S Chen, Steve R Otto, Marc S Schwartz, Gregory P Lekovic
OBJECTIVE: To report the preliminary outcomes of auditory brainstem implantation (ABI) under a compassionate use protocol for two ABI devices that are not approved by the US Food and Drug Administration. METHODS: A retrospective review was performed of neurofibromatosis type 2 (NF2) patients who underwent microsurgery for vestibular schwannoma (VS) and placement of either the Cochlear ABI541 or Med-El Synchrony ABIs. Peri-operative and device- related complications were reviewed...
January 18, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28077629/sun2-silencing-impairs-cd4-t-cell-proliferation-and-alters-sensitivity-to-hiv-1-infection-independently-of-cyclophilin-a
#13
Daniel A Donahue, Françoise Porrot, Norbert Couespel, Olivier Schwartz
: Linker of nucleoskeleton and cytoskeleton (LINC) complexes connect the nucleus to the cytoskeleton in eukaryotic cells. We previously reported that overexpression of SUN2, an inner nuclear membrane protein and LINC complex component, inhibits HIV infection between reverse transcription and nuclear import in a capsid-specific manner. We also reported that SUN2 silencing does not modulate HIV infection in several cell lines. Silencing of SUN2 was recently reported to decrease HIV infection of CD4 T cells, an effect suggested to result from modulation of CypA-dependent steps of HIV infection...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28032315/erratum-to-personal-identity-development-in-hispanic-immigrant-adolescents-links-with-positive-psychosocial-functioning-depressive-symptoms-and-externalizing-problems
#14
Seth J Schwartz, Jennifer B Unger, Alan Meca, Elma I Lorenzo-Blanco, Lourdes Baezconde-Garbanati, Miguel Ángel Cano, Brandy Piña-Watson, José Szapocznik, Byron L Zamboanga, David Córdova, Andrea J Romero, Tae Kyoung Lee, Daniel W Soto, Juan A Villamar, Karina M Lizzi, Sabrina E Des Rosiers, Monica Pattarroyo
No abstract text is available yet for this article.
December 28, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28002742/cadherin-diffusion-in-supported-lipid-bilayers-exhibits-calcium-dependent-dynamic-heterogeneity
#15
Yu Cai, Nitesh Shashikanth, Deborah E Leckband, Daniel K Schwartz
Ca(2+) ions are critical to cadherin ectodomain rigidity, which is required for the activation of adhesive functions. Therefore, changes in Ca(2+) concentration, both in vivo and in vitro, can affect cadherin conformation and function. We employed single-molecule tracking to measure the diffusion of cadherin ectodomains tethered to supported lipid bilayers at varying Ca(2+) concentrations. At a relatively high Ca(2+) concentration of 2 mM, cadherin molecules exhibited a fast diffusion coefficient that was identical to that of individual lipid molecules in the bilayer (Dfast ≈ 3 μm(2)/s)...
December 20, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27998280/misleading-early-blood-volume-changes-obtained-using-ferumoxytol-based-magnetic-resonance-imaging-perfusion-in-high-grade-glial-neoplasms-treated-with-bevacizumab
#16
Joao Prola Netto, Daniel Schwartz, Csanad Varallyay, Rongwei Fu, Bronwyn Hamilton, Edward A Neuwelt
BACKGROUND: Neovascularization, a distinguishing trait of high-grade glioma, is a target for anti-angiogenic treatment with bevacizumab (BEV). This study sought to use ferumoxytol-based dynamic susceptibility contrast magnetic resonance imaging (MRI) to clarify perfusion and relative blood volume (rCBV) changes in glioma treated with BEV and to determine potential impact on clinical management. METHODS: 16 high grade glioma patients who received BEV following post-chemoradiation radiographic or clinical progression were included...
December 20, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27977460/perioperative-outcomes-and-management-in-pediatric-complex-cranial-vault-reconstruction-a-multicenter-study-from-the-pediatric-craniofacial-collaborative-group
#17
Paul A Stricker, Susan M Goobie, Franklyn P Cladis, Charles M Haberkern, Petra M Meier, Srijaya K Reddy, Thanh T Nguyen, Lingyu Cai, Marcia Polansky, Peter Szmuk, John Fiadjoe, Codruta Soneru, Ricardo Falcon, Timothy Petersen, Courtney Kowalczyk-Derderian, Nicholas Dalesio, Stefan Budac, Neels Groenewald, Daniel Rubens, Douglas Thompson, Rheana Watts, Katherine Gentry, Iskra Ivanova, Mali Hetmaniuk, Vincent Hsieh, Michael Collins, Karen Wong, Wendy Binstock, Russell Reid, Kim Poteet-Schwartz, Heike Gries, Rebecca Hall, Jeffrey Koh, Carolyn Bannister, Wai Sung, Ranu Jain, Allison Fernandez, Gerald F Tuite, Ernesto Ruas, Oleg Drozhinin, Lisa Tetreault, Bridget Muldowney, Karene Ricketts, Patrick Fernandez, Lisa Sohn, John Hajduk, Brad Taicher, Jessica Burkhart, Allison Wright, Jane Kugler, Lea Barajas-DeLoa, Meera Gangadharan, Veronica Busso, Kayla Stallworth, Susan Staudt, Kristen L Labovsky, Chris D Glover, Henry Huang, Helena Karlberg-Hippard, Samantha Capehart, Cynthia Streckfus, Kim-Phuong T Nguyen, Peter Manyang, Jose Luis Martinez, Jennifer K Hansen, Heather Mitzel Levy, Alyssa Brzenski, Franklin Chiao, Pablo Ingelmo, Razaz Mujallid, Olutoyin A Olutoye, Tariq Syed, Hubert Benzon, Adrian Bosenberg
BACKGROUND: The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determine perioperative management, outcomes, and complications in children undergoing complex cranial vault reconstruction across North America and to delineate salient features of current practices...
February 2017: Anesthesiology
https://www.readbyqxmd.com/read/27956697/epithelial-hypoxia-inducible-factor-2%C3%AE-facilitates-the-progression-of-colon-tumors-through-recruiting-neutrophils
#18
Daniel Triner, Xiang Xue, Andrew J Schwartz, Inkyung Jung, Justin A Colacino, Yatrik M Shah
Inflammation is a significant risk factor for colon cancer. Recent work has demonstrated essential roles for several infiltrating immune populations in the metaplastic progression following inflammation. Hypoxia and stabilization of hypoxia-inducible factors (HIFs) are hallmark features of inflammation and solid tumors. Previously, we demonstrated an important role for tumor epithelial HIF-2α in colon tumors, however, the function of epithelial HIF-2α as a critical link in the progression of inflammation to cancer has not been elucidated...
December 12, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27956467/linc-complexes-promote-homologous-recombination-in-part-through-inhibition-of-nonhomologous-end-joining
#19
Katherine S Lawrence, Erin C Tapley, Victor E Cruz, Qianyan Li, Kayla Aung, Kevin C Hart, Thomas U Schwartz, Daniel A Starr, JoAnne Engebrecht
The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination. Loss of UNC-84 leads to defects in the loading and disassembly of the recombinase RAD-51. Similar to mutations in Fanconi anemia (FA) genes, unc-84 mutants and human cells depleted of Sun-1 are sensitive to DNA cross-linking agents, and sensitivity is rescued by the inactivation of nonhomologous end joining (NHEJ)...
December 19, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27955697/dna-methylation-signatures-of-chronic-low-grade-inflammation-are-associated-with-complex-diseases
#20
Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M Mendelson, Karen N Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L Waite, Roby Joehanes, Weihua Guan, Jennifer A Brody, Cathy Elks, Riccardo Marioni, Min A Jhun, Golareh Agha, Jan Bressler, Cavin K Ward-Caviness, Brian H Chen, Tianxiao Huan, Kelly Bakulski, Elias L Salfati, Giovanni Fiorito, Simone Wahl, Katharina Schramm, Jin Sha, Dena G Hernandez, Allan C Just, Jennifer A Smith, Nona Sotoodehnia, Luke C Pilling, James S Pankow, Phil S Tsao, Chunyu Liu, Wei Zhao, Simonetta Guarrera, Vasiliki J Michopoulos, Alicia K Smith, Marjolein J Peters, David Melzer, Pantel Vokonas, Myriam Fornage, Holger Prokisch, Joshua C Bis, Audrey Y Chu, Christian Herder, Harald Grallert, Chen Yao, Sonia Shah, Allan F McRae, Honghuang Lin, Steve Horvath, Daniele Fallin, Albert Hofman, Nicholas J Wareham, Kerri L Wiggins, Andrew P Feinberg, John M Starr, Peter M Visscher, Joanne M Murabito, Sharon L R Kardia, Devin M Absher, Elisabeth B Binder, Andrew B Singleton, Stefania Bandinelli, Annette Peters, Melanie Waldenberger, Giuseppe Matullo, Joel D Schwartz, Ellen W Demerath, André G Uitterlinden, Joyce B J van Meurs, Oscar H Franco, Yii-Der Ida Chen, Daniel Levy, Stephen T Turner, Ian J Deary, Kerry J Ressler, Josée Dupuis, Luigi Ferrucci, Ken K Ong, Themistocles L Assimes, Eric Boerwinkle, Wolfgang Koenig, Donna K Arnett, Andrea A Baccarelli, Emelia J Benjamin, Abbas Dehghan
BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. RESULTS: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111)...
December 12, 2016: Genome Biology
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