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https://www.readbyqxmd.com/read/28741794/ecological-segregation-moderates-a-climactic-conclusion-to-trout-hybridization
#1
Michael K Young, Daniel J Isaak, Kevin S McKelvey, Taylor M Wilcox, Matthew R Campbell, Matthew P Corsi, Dona L Horan, Michael K Schwartz
Invasive hybridization, in which an introduced species may introgressively hybridize with a native taxon and threaten its persistence, is prominently featured in the conservation literature. One of the most frequently cited examples of this phenomenon involves interactions between native westslope cutthroat trout Oncorhynchus clarkii lewisi and introduced rainbow trout O. mykiss in a portion of the U.S. Northern Rocky Mountains (Allendorf & Leary, 1988). This article is protected by copyright. All rights reserved...
July 25, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28722720/a-guiding-map-for-inflammation
#2
Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath, Evangelos J Giamarellos-Bourboulis, Douglas Golenbock, Mark S Gresnigt, Michael T Heneka, Hal M Hoffman, Richard Hotchkiss, Leo A B Joosten, Daniel L Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H G Mills, Kristen L Nowak, Luke A O'Neill, Peter Pickkers, Tom van der Poll, Paul M Ridker, Joost Schalkwijk, David A Schwartz, Britta Siegmund, Clifford J Steer, Herbert Tilg, Jos W M van der Meer, Frank L van de Veerdonk, Charles A Dinarello
Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.
July 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28720629/a-group-visit-initiative-improves-advance-care-planning-documentation-among-older-adults-in-primary-care
#3
Hillary D Lum, Rebecca L Sudore, Daniel D Matlock, Elizabeth Juarez-Colunga, Jacqueline Jones, Molly Nowels, Robert S Schwartz, Jean S Kutner, Cari R Levy
INTRODUCTION: Group visits for advance care planning (ACP) may help patients document preferences for decision makers and future care. We assessed the impact of a primary care-based ACP group visit (ACP-GV) intervention on older adults' ACP documentation and why patients participated. METHODS: Older adults (>65 years) in primary care participated in a 2-session ACP-GV intervention that promotes group dynamics, peer-based learning, and goal setting. Charts were reviewed at baseline, 3 months, and 12 months for documentation of decision makers and ACP forms...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28712573/ve-cadherin-phosphorylation-regulates-endothelial-fluid-shear-stress-responses-through-the-polarity-protein-lgn
#4
Daniel E Conway, Brian G Coon, Madhusuthan Budatha, Paul T Arsenovic, Fabrizio Orsenigo, Florian Wessel, Jiasheng Zhang, Zhenwu Zhuang, Elisabetta Dejana, Dietmar Vestweber, Martin A Schwartz
Fluid shear stress due to blood flow on the vascular endothelium regulates blood vessel development, remodeling, physiology, and pathology [1, 2]. A complex consisting of PECAM-1, VE-cadherin, and vascular endothelial growth factor receptors (VEGFRs) that resides at endothelial cell-cell junctions transduces signals important for flow-dependent vasodilation, blood vessel remodeling, and atherosclerosis. PECAM-1 transduces forces to activate src family kinases (SFKs), which phosphorylate and transactivate VEGFRs [3-5]...
July 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28658579/connecting-protein-conformation-and-dynamics-with-ligand-receptor-binding-using-three-color-f%C3%A3-rster-resonance-energy-transfer-tracking
#5
Mark Kastantin, David Faulón Marruecos, Navdeep Grover, Sean Yu McLoughlin, Daniel K Schwartz, Joel L Kaar
Specific binding between biomolecules, i.e., molecular recognition, controls virtually all biological processes including the interactions between cells and biointerfaces, both natural and synthetic. Such binding often relies on the conformation of biomacromolecules, which can be highly heterogeneous and sensitive to environmental perturbations, and therefore difficult to characterize and control. An approach is demonstrated here that directly connects the binding kinetics and stability of the protein receptor integrin αvβ3 to the conformation of the ligand fibronectin (FN), which are believed to control cellular mechanosensing...
July 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28658234/corrigendum-cd32a-is-a-marker-of-a-cd4-t-cell-hiv-reservoir-harbouring-replication-competent-proviruses
#6
Benjamin Descours, Gaël Petitjean, José-Luis López-Zaragoza, Timothée Bruel, Raoul Raffel, Christina Psomas, Jacques Reynes, Christine Lacabaratz, Yves Levy, Olivier Schwartz, Jean Daniel Lelievre, Monsef Benkirane
This corrects the article DOI: 10.1038/nature21710.
June 28, 2017: Nature
https://www.readbyqxmd.com/read/28640828/bovine-leukemia-virus-linked-to-breast-cancer-in-australian-women-and-identified-before-breast-cancer-development
#7
Gertrude C Buehring, HuaMin Shen, Daniel A Schwartz, James S Lawson
Bovine leukemia virus (BLV), a common virus of cattle globally, was believed for decades not to infect humans. More recent techniques (in situ PCR and DNA sequencing) enabled detection of BLV in human breast tissue, and determination of its significant association with breast cancer in a US population. Using similar techniques to study 96 Australian women, we report here detection of retrotranscribed BLV DNA in breast tissue of 40/50(80%) of women with breast cancer versus 19/46(41%) of women with no history of breast cancer, indicating an age-adjusted odds ratio and confidence interval of 4...
2017: PloS One
https://www.readbyqxmd.com/read/28640031/identifying-gaps-in-the-performance-of-pediatric-trainees-who-receive-marginal-unsatisfactory-ratings
#8
Su-Ting T Li, Daniel J Tancredi, Alan Schwartz, Ann Guillot, Ann Burke, R Franklin Trimm, Susan Guralnick, John D Mahan, Kimberly A Gifford
PURPOSE: To perform a derivation study to determine in which subcompetencies marginal/unsatisfactory pediatric residents had the greatest deficits compared with their satisfactorily performing peers and which subcompetencies best discriminated between marginal/unsatisfactory and satisfactorily performing residents. METHOD: Multi-institutional cohort study of all 21 milestones (rated on four or five levels) reported to the Accreditation Council for Graduate Medical Education, and global marginal/unsatisfactory versus satisfactory performance reported to the American Board of Pediatrics...
June 20, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28631307/interventions-for-the-prevention-of-recurrent-erysipelas-and-cellulitis
#9
REVIEW
Adam Dalal, Marina Eskin-Schwartz, Daniel Mimouni, Sujoy Ray, Walford Days, Emmilia Hodak, Leonard Leibovici, Mical Paul
BACKGROUND: Erysipelas and cellulitis (hereafter referred to as 'cellulitis') are common bacterial skin infections usually affecting the lower extremities. Despite their burden of morbidity, the evidence for different prevention strategies is unclear. OBJECTIVES: To assess the beneficial and adverse effects of antibiotic prophylaxis or other prophylactic interventions for the prevention of recurrent episodes of cellulitis in adults aged over 16. SEARCH METHODS: We searched the following databases up to June 2016: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and LILACS...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28628351/sleep-in-adolescents-and-young-adults-in-the-year-after-cancer-treatment
#10
Lauren C Daniel, Richa Aggarwal, Lisa A Schwartz
PURPOSE: Adolescents and young adults (AYA) with cancer are a vulnerable group facing more intense treatments, higher symptom burden, and poorer treatment outcomes relative to younger children. Sleep disruption is common during cancer treatment and sleep problems persist into adulthood for some survivors of AYA cancer. The developmental period of adolescence/emerging adulthood confers greater biological and behavioral risk for insufficient sleep relative to older or younger ages. Thus, understanding AYA sleep disturbances shortly after completing treatment can inform interventions to manage cancer-related symptoms and improve quality of life...
June 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28617996/gradient-nonlinearity-effects-on-upper-cervical-spinal-cord-area-measurement-from-3d-t1-weighted-brain-mri-acquisitions
#11
Nico Papinutto, Rohit Bakshi, Antje Bischof, Peter A Calabresi, Eduardo Caverzasi, R Todd Constable, Esha Datta, Gina Kirkish, Govind Nair, Jiwon Oh, Daniel Pelletier, Dzung L Pham, Daniel S Reich, William Rooney, Snehashis Roy, Daniel Schwartz, Russell T Shinohara, Nancy L Sicotte, William A Stern, Ian Tagge, Shahamat Tauhid, Subhash Tummala, Roland G Henry
PURPOSE: To explore (i) the variability of upper cervical cord area (UCCA) measurements from volumetric brain 3D T1 -weighted scans related to gradient nonlinearity (GNL) and subject positioning; (ii) the effect of vendor-implemented GNL corrections; and (iii) easily applicable methods that can be used to retrospectively correct data. METHODS: A multiple sclerosis patient was scanned at seven sites using 3T MRI scanners with the same 3D T1 -weighted protocol without GNL-distortion correction...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28607687/glomerular-filtration-rate-trends-during-follow-up-in-children-with-steroid-sensitive-nephrotic-syndrome
#12
Sulaiman Alsaidi, Daniel Wagner, Silviu Grisaru, Julian Midgley, Lorraine Hamiwka, Andrew Wade, Alberto Nettel-Aguirre, Susan Samuel
BACKGROUND: Overall prognosis of children with steroid-sensitive nephrotic syndrome (SSNS) is regarded as generally favorable. However, only a few recent studies have evaluated changes in kidney function and blood pressure over time in children with SSNS. OBJECTIVES: We describe clinical features of SSNS patients and characterize changes in calculated estimated glomerular filtration rate (eGFR) and use of antihypertensive medications during follow-up. DESIGN: This is a retrospective cohort study...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28598928/occupation-and-obstructive-sleep-apnea-a-meta-analysis
#13
Daniel A Schwartz, Denis Vinnikov, Paul D Blanc
OBJECTIVE: Obstructive sleep apnea (OSA) remains a prevalent condition, but its occupational burden is unclear. We carried out a systematic review to characterize the consistency and magnitude of occupational associations with OSA. METHODS: We studied OSA within three occupational categories: commercial drivers, organic solvent-exposed workers, other selected occupations. We performed a meta-analysis on the prevalence of OSA among drivers and the risk of OSA associated with solvent exposure...
June 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28557947/validity-evidence-from-ratings-of-pediatric-interns-and-subinterns-on-a-subset-of-pediatric-milestones
#14
Teri L Turner, Vasudha L Bhavaraju, Ulana A Luciw-Dubas, Patricia J Hicks, Sara Multerer, Amanda Osta, Jennifer McDonnell, Sue Poynter, Daniel J Schumacher, Rebecca Tenney-Soeiro, Linda Waggoner-Fountain, Alan Schwartz
PURPOSE: To investigate evidence for validity of faculty members' pediatric milestone (PM) ratings of interns (first-year residents) and subinterns (fourth-year medical students) on nine subcompetencies related to readiness to serve as a pediatric intern in the inpatient setting. METHOD: The Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network (APPD LEARN) and the National Board of Medical Examiners collaborated to investigate the utility of assessments of the PMs for trainees' performance...
June 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28544348/galectin-1-promotes-an-m2-macrophage-response-to-polydioxanone-scaffolds
#15
Daniel Abebayehu, Andrew Spence, Barbara D Boyan, Zvi Schwartz, John J Ryan, Michael J McClure
Regulating soft tissue repair to prevent fibrosis and promote regeneration is central to creating a microenvironment conducive to soft tissue development. Macrophages play an important role in this process. The macrophage response can be modulated using biomaterials, altering cytokine and growth factor secretion to promote regeneration. Electrospun polydioxanone (PDO) fiber scaffolds promoted an M2 phenotype when macrophages were cultured on large diameter, highly porous scaffolds, but an M1 phenotype on smaller diameter fibers...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28502388/the-grapefruit-an-alternative-arthroscopic-tool-skill-platform
#16
David A Molho, Stephen M Sylvia, Daniel L Schwartz, Sara L Merwin, I Martin Levy
PURPOSE: To establish the construct validity of an arthroscopic training model that teaches arthroscopic tool skills including triangulation, grasping, precision biting, implant delivery and ambidexterity and uses a whole grapefruit for its training platform. METHODS: For the grapefruit training model (GTM), an arthroscope and arthroscopic instruments were introduced through portals cut in the grapefruit skin of a whole prepared grapefruit. After institutional review board approval, participants performed a set of tasks inside the grapefruit...
May 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28473303/gapmap-enabling-comprehensive-autism-resource-epidemiology
#17
Nikhila Albert, Jena Daniels, Jessey Schwartz, Michael Du, Dennis P Wall
BACKGROUND: For individuals with autism spectrum disorder (ASD), finding resources can be a lengthy and difficult process. The difficulty in obtaining global, fine-grained autism epidemiological data hinders researchers from quickly and efficiently studying large-scale correlations among ASD, environmental factors, and geographical and cultural factors. OBJECTIVE: The objective of this study was to define resource load and resource availability for families affected by autism and subsequently create a platform to enable a more accurate representation of prevalence rates and resource epidemiology...
May 4, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28471438/electronic-health-record-phenotype-in-subjects-with-genetic-variants-associated-with-arrhythmogenic-right-ventricular-cardiomyopathy-a-study-of-30-716-subjects-with-exome-sequencing
#18
Christopher M Haggerty, Cynthia A James, Hugh Calkins, Crystal Tichnell, Joseph B Leader, Dustin N Hartzel, Christopher D Nevius, Sarah A Pendergrass, Thomas N Person, Marci Schwartz, Marylyn D Ritchie, David J Carey, David H Ledbetter, Marc S Williams, Frederick E Dewey, Alexander Lopez, John Penn, John D Overton, Jeffrey G Reid, Matthew Lebo, Heather Mason-Suares, Christina Austin-Tse, Heidi L Rehm, Brian P Delisle, Daniel J Makowski, Vishal C Mehra, Michael F Murray, Brandon K Fornwalt
PurposeArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease. Clinical follow-up of incidental findings in ARVC-associated genes is recommended. We aimed to determine the prevalence of disease thus ascertained.MethodsIndividuals (n = 30,716) underwent exome sequencing. Variants in PKP2, DSG2, DSC2, DSP, JUP, TMEM43, or TGFβ3 that were database-listed as pathogenic or likely pathogenic were identified and evidence-reviewed. For subjects with putative loss-of-function (pLOF) variants or variants of uncertain significance (VUS), electronic health records (EHR) were reviewed for ARVC diagnosis, diagnostic criteria, and International Classification of Diseases (ICD-9) codes...
May 4, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28440982/-intelligence-quotient-loss-in-mexican-pottery-artisan-s-children
#19
Daniel Estrada-Sánchez, Bret Ericson, Cuauhtémoc Arturo Juárez-Pérez, Guadalupe Aguilar-Madrid, Lina Hernández, Sandra Gualtero, Jack Caravanos
BACKGROUND: In Mexico, artisans frequently use lead oxide or greta in order to produce utensils, which are destined to preparation and storage of food and drinks. Additionally, the risk of lead poisoning of artisans and their families is greater than in general population, and within these families, children are the most susceptible to lead poisoning. The aim of this study was to estimate IQ loss in Mexican children from potter families exposed to lead. METHODS: Lead concentrations in soil were determined in 19 potter's homes that functioned as pottery workshops in seven Mexican states between 2009 and 2012...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28440802/genetic-hurdles-limit-the-arms-race-between-prochlorococcus-and-the-t7-like-podoviruses-infecting-them
#20
Daniel A Schwartz, Debbie Lindell
Phages and hosts coexist in nature with a high degree of population diversity. This is often explained through coevolutionary models, such as the arms race or density-dependent fluctuating selection, which differ in assumptions regarding the emergence of phage mutants that overcome host resistance. Previously, resistance in the abundant marine cyanobacterium, Prochlorococcus, was found to occur frequently. However, little is known about the ability of phages to overcome this resistance. Here we report that, in some cases, T7-like cyanophage mutants emerge to infect resistant Prochlorococcus strains...
August 2017: ISME Journal
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