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https://www.readbyqxmd.com/read/29161008/mapping-the-functional-tortuosity-and-spatio-temporal-heterogeneity-of-porous-polymer-membranes-with-super-resolution-nanoparticle-tracking
#1
Yu Cai, Daniel K Schwartz
As particles flow through porous media, they follow complex pathways and experience heterogeneous environments that are challenging to characterize. Tortuosity is often used as a parameter to characterize the complexity of pathways in porous materials and is useful in understanding hindered mass transport in industrial filtration and mass separation processes. However, conventional calculations of tortuosity provide only average values under static conditions; they are insensitive to the intrinsic heterogeneity of porous media and do not account for potential effects of operating conditions...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29123087/live-imaging-molecular-changes-in-junctional-tension-upon-ve-cadherin-in-zebrafish
#2
Anne Karine Lagendijk, Guillermo A Gomez, Sungmin Baek, Daniel Hesselson, William E Hughes, Scott Paterson, Daniel E Conway, Heinz-Georg Belting, Markus Affolter, Kelly A Smith, Martin A Schwartz, Alpha S Yap, Benjamin M Hogan
Forces play diverse roles in vascular development, homeostasis and disease. VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoskeletons of adjacent cells, serving as a tension-transducer. To explore tensile changes across VE-cadherin in live zebrafish, we tailored an optical biosensor approach, originally established in vitro. We validate localization and function of a VE-cadherin tension sensor (TS) in vivo. Changes in tension across VE-cadherin observed using ratio-metric or lifetime FRET measurements reflect acto-myosin contractility within endothelial cells...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29106329/the-naims-cooperative-pilot-project-design-implementation-and-future-directions
#3
Jiwon Oh, Rohit Bakshi, Peter A Calabresi, Ciprian Crainiceanu, Roland G Henry, Govind Nair, Nico Papinutto, R Todd Constable, Daniel S Reich, Daniel Pelletier, William Rooney, Daniel Schwartz, Ian Tagge, Russell T Shinohara, Jack H Simon, Nancy L Sicotte
The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29090534/challenges-and-advantages-in-wide-field-optical-coherence-tomography-angiography-imaging-of-the-human-retinal-and-choroidal-vasculature-at-1-7-mhz-a-scan-rate
#4
Raju Poddar, Justin V Migacz, Daniel M Schwartz, John S Werner, Iwona Gorczynska
We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29090073/anatomic-humeral-head-replacement-with-a-press-fit-prosthesis-an-in-vivo-radiographic-study
#5
REVIEW
Bryan Vopat, Jeremy Truntzer, Daniel Aaron, Jack Anavian, Joel Schwartz, Andrew Green
No abstract text is available yet for this article.
September 30, 2017: Orthopedic Reviews
https://www.readbyqxmd.com/read/29080642/current-controversies-are-free-vitamin-metabolite-levels-a-more-accurate-assessment-of-vitamin-d-status-than-total-levels
#6
REVIEW
Daniel D Bikle, Sofie Malmstroem, Janice Schwartz
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert their biologic effects. For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)2D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively). Assays to measure the free vitamin D metabolite levels have been developed, and initial studies indicated their value in subjects with altered DBP levels...
December 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29079569/associations-of-nocturnal-blood-pressure-with-cognition-by-self-identified-race-in-middle-aged-and-older-adults-the-genoa-genetic-epidemiology-network-of-arteriopathy-study
#7
Yuichiro Yano, Kenneth R Butler, Michael E Hall, Gary L Schwartz, David S Knopman, Seth T Lirette, Daniel W Jones, James G Wilson, John E Hall, Adolfo Correa, Stephen T Turner, Thomas H Mosley
BACKGROUND: Whether the association of blood pressure (BP) during sleep (nocturnal BP) with cognition differs by race is unknown. METHODS AND RESULTS: Participants in the GENOA (Genetic Epidemiology Network of Arteriopathy) Study underwent ambulatory BP measurements, brain magnetic resonance imaging, and cognitive function testing (the Rey Auditory Verbal Learning Test, the Digit Symbol Substitution Task, and the Trail Making Test Part B) between 2000 and 2007. We examined multivariable linear regression models of the nocturnal BP-cognition association...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29079275/endometriosis-especially-mild-disease-a-risk-factor-for-miscarriages
#8
MULTICENTER STUDY
Alexandra Sabrina Kohl Schwartz, Monika Martina Wölfler, Vera Mitter, Martina Rauchfuss, Felix Haeberlin, Markus Eberhard, Stephanie von Orelli, Bruno Imthurn, Patrick Imesch, Daniel Fink, Brigitte Leeners
OBJECTIVE: To investigate the prevalence of miscarriage in women with endometriosis (WwE) compared with disease-free control women (CW). DESIGN: Cross-sectional analysis nested in a retrospective observational study (n = 940). SETTING: Hospitals and associated private practices. PATIENT(S): Previously pregnant women (n = 268) within reproductive age in matched pairs. INTERVENTION(S): Retrospective analysis of surgical reports and self-administered questionnaires...
November 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29078299/finding-water-scarcity-amid-abundance-using-human-natural-system-models
#9
William K Jaeger, Adell Amos, Daniel P Bigelow, Heejun Chang, David R Conklin, Roy Haggerty, Christian Langpap, Kathleen Moore, Philip W Mote, Anne W Nolin, Andrew J Plantinga, Cynthia L Schwartz, Desiree Tullos, David P Turner
Water scarcity afflicts societies worldwide. Anticipating water shortages is vital because of water's indispensable role in social-ecological systems. But the challenge is daunting due to heterogeneity, feedbacks, and water's spatial-temporal sequencing throughout such systems. Regional system models with sufficient detail can help address this challenge. In our study, a detailed coupled human-natural system model of one such region identifies how climate change and socioeconomic growth will alter the availability and use of water in coming decades...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29075431/the-gapmap-project-a-mobile-surveillance-system-to-map-diagnosed-autism-cases-and-gaps-in-autism-services-globally
#10
Jena Daniels, Jessey Schwartz, Nikhila Albert, Michael Du, Dennis P Wall
Although the number of autism diagnoses is on the rise, we have no evidence-based tracking of size and severity of gaps in access to autism-related resources, nor do we have methods to geographically triangulate the locations of the widest gaps in either the US or elsewhere across the globe. To combat these related issues of (1) mapping diagnosed cases of autism and (2) quantifying gaps in access to key intervention services, we have constructed a crowd-based mobile platform called "GapMap" (http://gapmap.stanford...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29073603/vascular-endothelial-dysfunction-during-cardiac-surgery-on-pump-versus-off-pump-coronary-surgery
#11
Florian Brettner, Daniel Chappell, Lisa Schwartz, Alexander Lukasz, Philipp Kümpers, Bernhard F Becker, Bruno Reichart, Markus Rehm, Dirk Bruegger
BACKGROUND: Cardiac surgery often causes ischemia and development of a systemic inflammatory response syndrome, which impairs vascular barrier function, normally maintained by the endothelial cell line and the endothelial glycocalyx (EG). The EG normally covers and protects healthy endothelial cells throughout the vasculature. The aim of the present study was to assess the disruption of the cellular part of the microvascular barrier by determining parameters of endothelial cell activation known to influence and reflect cell-cell junctional integrity...
October 26, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29053105/biological-and-dosimetric-characterisation-of-spatially-fractionated-proton-minibeams
#12
Juergen Meyer, Robert D Stewart, Daniel Smith, James Eagle, Eunsin Lee, Ning Cao, Eric Ford, Reza Hashemian, Jan Schuemann, Jatinder Saini, Steven Marsh, Robert Emery, Eric Dorman, Jeffrey L Schwartz, George A Sandison
The biological effectiveness of proton beams varies with depth, spot size and lateral distance from the beam central axis. The aim of this work is to incorporate proton relative biological effectiveness (RBE) and equivalent uniform dose (EUD) considerations into comparisons of broad beam and highly modulated proton minibeams. A Monte Carlo model of a small animal proton beamline is presented. Dose and variable RBE is calculated on a per-voxel basis for a range of energies (30-109 MeV). For an open beam, the RBE values at the beam entrance ranged from 1...
October 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29046041/development-and-content-validation-of-the-transition-readiness-inventory-item-pool-for-adolescent-and-young-adult-survivors-of-childhood-cancer
#13
Lisa A Schwartz, Jessica L Hamilton, Lauren D Brumley, Lamia P Barakat, Janet A Deatrick, Dava E Szalda, Katherine B Bevans, Carole A Tucker, Lauren C Daniel, Eliana Butler, Anne E Kazak, Wendy L Hobbie, Jill P Ginsberg, Alexandra M Psihogios, Elizabeth Ver Hoeve, Lisa K Tuchman
Objective: The development of the Transition Readiness Inventory (TRI) item pool for adolescent and young adult childhood cancer survivors is described, aiming to both advance transition research and provide an example of the application of NIH Patient Reported Outcomes Information System methods. Methods: Using rigorous measurement development methods including mixed methods, patient and parent versions of the TRI item pool were created based on the Social-ecological Model of Adolescent and young adult Readiness for Transition (SMART)...
October 1, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29029073/clinical-genetics-and-outcome-of-left-ventricular-non-compaction-cardiomyopathy
#14
Farbod Sedaghat-Hamedani, Jan Haas, Feng Zhu, Christian Geier, Elham Kayvanpour, Martin Liss, Alan Lai, Karen Frese, Regina Pribe-Wolferts, Ali Amr, Daniel Tian Li, Omid Shirvani Samani, Avisha Carstensen, Diana Martins Bordalo, Marion Müller, Christine Fischer, Jing Shao, Jing Wang, Ming Nie, Li Yuan, Sabine Haßfeld, Christine Schwartz, Min Zhou, Zihua Zhou, Yanwen Shu, Min Wang, Kai Huang, Qiutang Zeng, Longxian Cheng, Tobias Fehlmann, Philipp Ehlermann, Andreas Keller, Christoph Dieterich, Katrin Streckfuß-Bömeke, Yuhua Liao, Michael Gotthardt, Hugo A Katus, Benjamin Meder
Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause of heart failure, arrhythmia, thromboembolism, and sudden cardiac death. We sought here to dissect its genetic causes, phenotypic presentation and outcome. Methods and results: In our registry with follow-up of in the median 61 months, we analysed 95 LVNC patients (68 unrelated index patients and 27 affected relatives; definite familial LVNC = 23...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29025028/cohort-profile-pregnancy-and-childhood-epigenetics-pace-consortium
#15
Janine F Felix, Bonnie R Joubert, Andrea A Baccarelli, Gemma C Sharp, Catarina Almqvist, Isabella Annesi-Maesano, Hasan Arshad, Nour Baïz, Marian J Bakermans-Kranenburg, Kelly M Bakulski, Elisabeth B Binder, Luigi Bouchard, Carrie V Breton, Bert Brunekreef, Kelly J Brunst, Esteban G Burchard, Mariona Bustamante, Leda Chatzi, Monica Cheng Munthe-Kaas, Eva Corpeleijn, Darina Czamara, Dana Dabelea, George Davey Smith, Patrick De Boever, Liesbeth Duijts, Terence Dwyer, Celeste Eng, Brenda Eskenazi, Todd M Everson, Fahimeh Falahi, M Daniele Fallin, Sara Farchi, Mariana F Fernandez, Lu Gao, Tom R Gaunt, Akram Ghantous, Matthew W Gillman, Semira Gonseth, Veit Grote, Olena Gruzieva, Siri E Håberg, Zdenko Herceg, Marie-France Hivert, Nina Holland, John W Holloway, Cathrine Hoyo, Donglei Hu, Rae-Chi Huang, Karen Huen, Marjo-Riitta Järvelin, Dereje D Jima, Allan C Just, Margaret R Karagas, Robert Karlsson, Wilfried Karmaus, Katerina J Kechris, Juha Kere, Manolis Kogevinas, Berthold Koletzko, Gerard H Koppelman, Leanne K Küpers, Christine Ladd-Acosta, Jari Lahti, Nathalie Lambrechts, Sabine A S Langie, Rolv T Lie, Andrew H Liu, Maria C Magnus, Per Magnus, Rachel L Maguire, Carmen J Marsit, Wendy McArdle, Erik Melén, Phillip Melton, Susan K Murphy, Tim S Nawrot, Lorenza Nisticò, Ellen A Nohr, Björn Nordlund, Wenche Nystad, Sam S Oh, Emily Oken, Christian M Page, Patrice Perron, Göran Pershagen, Costanza Pizzi, Michelle Plusquin, Katri Raikkonen, Sarah E Reese, Eva Reischl, Lorenzo Richiardi, Susan Ring, Ritu P Roy, Peter Rzehak, Greet Schoeters, David A Schwartz, Sylvain Sebert, Harold Snieder, Thorkild I A Sørensen, Anne P Starling, Jordi Sunyer, Jack A Taylor, Henning Tiemeier, Vilhelmina Ullemar, Marina Vafeiadi, Marinus H Van Ijzendoorn, Judith M Vonk, Annette Vriens, Martine Vrijheid, Pei Wang, Joseph L Wiemels, Allen J Wilcox, Rosalind J Wright, Cheng-Jian Xu, Zongli Xu, Ivana V Yang, Paul Yousefi, Hongmei Zhang, Weiming Zhang, Shanshan Zhao, Golareh Agha, Caroline L Relton, Vincent W V Jaddoe, Stephanie J London
No abstract text is available yet for this article.
September 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023127/surface-mediated-dna-hybridization-effects-of-dna-conformation-surface-chemistry-and-electrostatics
#16
Jeremiah C Traeger, Daniel K Schwartz
Single-molecule Förster Resonance Energy Transfer (FRET) was used to study the dynamic association of mobile donor-labeled ssDNA oligonucleotides ("target") with covalently immobilized complementary acceptor-labeled ssDNA oligonucleotides ("probe"). While probe-target association events were resolved for all experiments, such FRET events were far more likely to occur in systems with complementarity and on hydrophobic, as compared to hydrophilic, surfaces. The distribution of donor-acceptor association-time intervals did not exhibit simple first-order kinetics, and when decomposed into a superposition of first-order processes, only a small fraction of events corresponded to a long-lived state that was presumed to represent true DNA hybridization, while the majority of association events were transient, representing nonspecific associations or partial hybridization...
October 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28970737/association-between-socio-ecological-risk-factor-clustering-and-mental-emotional-and-behavioral-problems-in-hispanic-adolescents
#17
Lila Asfour, Shi Huang, Manuel A Ocasio, Tatiana Perrino, Seth J Schwartz, Daniel J Feaster, Mildred Maldonado-Molina, Hilda Pantin, Guillermo Prado
Compared to non-Hispanic whites, Hispanic adolescents in the U.S. report higher rates of several mental, emotional, and behavioral (MEB) problems such as substance use, sexual risk behaviors, and internalizing and externalizing problems. There is evidence of common pathways in the development of MEB problems with certain subgroups of Hispanic adolescents being at greater risk. In the present article, we report analysis of baseline data for 959 Hispanic adolescents who participated in one of two randomized controlled trials evaluating a family-based preventive intervention...
May 2017: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/28957341/efficacy-and-safety-of-sequential-versus-quadruple-therapy-as-second-line-treatment-for-helicobacter-pylori-infection-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Daniela Munteanu, Ohad Etzion, Gil Ben-Yakov, Daniel Halperin, Leslie Eidelman, Doron Schwartz, Victor Novack, Naim Abufreha, Pavel Krugliak, Alexander Rozenthal, Nava Gaspar, Alexander Moshkalo, Vitaly Dizingof, Alexander Fich
BACKGROUND AND AIMS: Quadruple therapy is recommended as second-line treatment for Helicobacter pylori eradication failure. However, high cost, multiple side effects, and low adherence rates are major drawbacks to its routine use. Our aim was to compare the efficacy and safety of sequential versus quadruple regimens as second line treatment for persistent Helicobacter pylori infection. METHODS: Prospective, randomized, open label trial was conducted at a large academic, tertiary care center in Israel...
2017: PloS One
https://www.readbyqxmd.com/read/28925353/sec17-%C3%AE-snap-and-an-sm-tethering-complex-regulate-the-outcome-of-snare-zippering-in-vitro-and-in-vivo
#19
Matthew L Schwartz, Daniel P Nickerson, Braden T Lobingier, Rachael L Plemel, Mengtong Duan, Cortney G Angers, Michael Zick, Alexey J Merz
Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and its SM subunit Vps33, is followed by subsequent zippering transitions that increase the probability of fusion. Operating independently of Sec18 (NSF) catalysis, Sec17 (α-SNAP) either inhibits or stimulates SNARE-mediated fusion. If HOPS or Vps33 are absent, Sec17 inhibits fusion at an early stage...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28905949/electronic-and-molecular-structure-relations-in-diiron-compounds-mimicking-the-fefe-hydrogenase-active-site-studied-by-x-ray-spectroscopy-and-quantum-chemistry
#20
Ramona Kositzki, Stefan Mebs, Nils Schuth, Nils Leidel, Lennart Schwartz, Michael Karnahl, Florian Wittkamp, Daniel Daunke, Andreas Grohmann, Ulf-Peter Apfel, Frédéric Gloaguen, Sascha Ott, Michael Haumann
Synthetic diiron compounds of the general formula Fe2(μ-S2R)(CO)n(L)6-n (R = alkyl or aromatic groups; L = CN(-) or phosphines) are versatile models for the active-site cofactor of hydrogen turnover in [FeFe]-hydrogenases. A series of 18 diiron compounds, containing mostly a dithiolate bridge and terminal ligands of increasing complexity, was characterized by X-ray absorption and emission spectroscopy in combination with density functional theory. Fe K-edge absorption and Kβ main-line emission spectra revealed the varying geometry and the low-spin state of the Fe(i) centers...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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