keyword
https://read.qxmd.com/read/38247004/the-epidemiology-and-the-pathogen-distribution-of-pediatric-dacryocystitis-in-chinese-population-2017-2022
#1
JOURNAL ARTICLE
Zhihong Sun, Mingchao Li, Huiqing Sun
BACKGROUND: Dacryocystitis is a common disease in pediatric ophthalmology. Analysis of basic information, flora distribution, and characteristics of information on drug-resistant bacteria in children with dacryocystitis for 6 years, providing evidence for ophthalmologic infection prevention and clinical management strategies. METHODS: A retrospective cohort study was conducted to evaluate the demographics of dacryocystitis in children and microbiological characteristics of secretion cultures, and to analyze the basic information, distribution of pathogenic bacteria, drug resistance, and to plot trendsand distribution pie charts according to the years...
January 22, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38241304/incidence-pathogens-and-antimicrobial-resistance-of-blood-and-cerebrospinal-fluid-isolates-from-a-tertiary-neonatal-unit-in-south-africa-a-10-year-retrospective-review
#2
JOURNAL ARTICLE
Reenu Thomas, Claude Ondongo-Ezhet, Nini Motsoaledi, Mike Sharland, Michelle Clements, Sithembiso Velaphi
OBJECTIVE: To determine trends in incidence, etiology and antimicrobial susceptibility of blood and cerebrospinal fluid (CSF) culture confirmed infections in hospitalized infants in a large tertiary neonatal unit in South Africa. METHODS: Single-center, retrospective review of laboratory records of bacteria and fungi, and their susceptibility profiles, isolated from blood and CSF of infants hospitalized in the neonatal unit at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa, from 1st January 2010 to 31st December 2019...
2024: PloS One
https://read.qxmd.com/read/37849791/a-multicenter-epidemiological-and-pathogenic-characteristics-study-of-community-acquired-bacterial-meningitis-children-in-china-results-from-the-chinese-pediatric-bacterial-meningitis-surveillance-cpbms-2019-2020
#3
JOURNAL ARTICLE
Caiyun Wang, Hongmei Xu, Gang Liu, Jing Liu, Hui Yu, Biquan Chen, Guo Zheng, Min Shu, Lijun Du, Zhiwei Xu, Lisu Huang, Haibo Li, Sainan Shu, Yinghu Chen
OBJECTIVE: To explore the epidemiological and pathogenic characteristics of children with community-acquired bacterial meningitis. METHODS: A multicenter, retrospective study was conducted among CABM patients under 15 years old from 33 hospitals in China from 2019 to 2020. The medical record, laboratory, and microbiological data were collected and analyzed. RESULTS: A total of 1610 children with CABM were identified and presented at a median onset age of 45 days of whom 955 (59...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37810008/congenital-pulmonary-lymphatic-duct-hypoplasia-in-a-fetus-with-hydrops-fetalis-found-at-delivery-a-case-report
#4
Hua-Chu Zuo, Lin-Sheng Zhao, Mei-Jiao Qi, Xiao-Li Hu
OBJECTIVE: To elaborate the clinical characteristics of congenital pulmonary lymphangiectasia in a neonate with hydrops fetalis. This could be an alert in considering it as a differential diagnosis for neonates with acute respiratory failure. METHODS: We reviewed and analyzed single-center registry patients who underwent cadaveric autopsies in the Department of Pathology at Children's Hospital from January 1, 2010 to December 31, 2021. We aimed to explore the perinatal clinical manifestations associated with congenital pulmonary lymphangiectasis (CPL)...
September 2023: Heliyon
https://read.qxmd.com/read/37364138/etiology-of-bacterial-sepsis-and-isolate-resistance-patterns-in-hospitalized-neonates-in-zambia
#5
JOURNAL ARTICLE
Franklyn N Egbe, Carter Cowden, Lawrence Mwananyanda, Cassandra Pierre, James Mwansa, Chileshe Lukwesa Musyani, Angela Lyondo, Monica L Kapasa, Sylvia Machona, Moses M Chilufya, Gertrude Munanjala, Susan E Coffin, Davidson H Hamer, Matthew A Bates
BACKGROUND: The Sepsis Prevention in Neonates in Zambia study is a prospective cohort study that evaluated an infection prevention and control (IPC) bundle in the University Teaching Hospital neonatal intensive care unit (NICU) in Lusaka, Zambia. We present here the etiologies, antimicrobial resistance profiles, and associated mortality of bloodstream infections (BSI) in this cohort. METHODS: Venous blood was collected from neonates with clinically suspected sepsis and cultured with an automated blood culture system...
June 26, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/37007668/neonatal-covid-19-with-atypical-lung-cystic-lesions-mimicking-congenital-pulmonary-airway-malformation-a-diagnostic-dilemma
#6
Salman Ghazwani
The COVID-19 epidemic is a major public health emergency that has affected every part of society worldwide, including neonates with different clinical presentations. It is essential to differentiate between increased incidence of complications related to this infection rather than an underlying congenital etiology. We report a rare case with atypical lung cystic lesions, diagnosed initially as congenital pulmonary airway malformation (CPAM) with management controversy but which turned out to be a COVID-19 viral pneumonia complication...
2023: International Medical Case Reports Journal
https://read.qxmd.com/read/36945972/can-surfactants-affect-mortality-and-morbidity-in-term-infants-with-respiratory-failure
#7
JOURNAL ARTICLE
Senem Alkan Özdemir, Özlem Yılman, Şebnem Çalkavur, Tülin Gökmen Yıldırım
BACKGROUND: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. METHODS: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system...
December 2022: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/36864913/bacterial-meningitis-in-africa
#8
REVIEW
Tatiana Barichello, Carlos Henrique Rocha Catalão, Ursula K Rohlwink, Martijn van der Kuip, Dan Zaharie, Regan S Solomons, Ronald van Toorn, Marceline Tutu van Furth, Rodrigo Hasbun, Federico Iovino, Vivian Ssonko Namale
Bacterial meningitis differs globally, and the incidence and case fatality rates vary by region, country, pathogen, and age group; being a life-threatening disease with a high case fatality rate and long-term complications in low-income countries. Africa has the most significant prevalence of bacterial meningitis illness, and the outbreaks typically vary with the season and the geographic location, with a high incidence in the meningitis belt of the sub-Saharan area from Senegal to Ethiopia. Streptococcus pneumoniae (pneumococcus) and Neisseria meningitidis (meningococcus) are the main etiological agents of bacterial meningitis in adults and children above the age of one...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36846166/the-dilemma-of-improving-rational-antibiotic-use-in-pediatric-community-acquired-pneumonia
#9
REVIEW
Phuong T K Nguyen, Paul D Robinson, Dominic A Fitzgerald, Ben J Marais
Pneumonia is the number one cause of disease and deaths in children under five years old, outside the neonatal period, with the greatest number of cases reported from resource-limited settings. The etiology is variable, with not much information on the local etiology drug resistance profile in many countries. Recent studies suggest an increasing contribution from respiratory viruses, also in children with severe pneumonia, with an increased relative contribution in settings that have good vaccine coverage against common bacterial pathogens...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/36671251/epidemiological-analysis-of-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-outbreak-in-a-neonatal-clinic-in-poland
#10
JOURNAL ARTICLE
Agata Pruss, Paweł Kwiatkowski, Helena Masiuk, Iwona Bilska, Stefania Giedrys-Kalemba, Barbara Dołęgowska
Klebsiella pneumoniae is one of the most common etiological agents isolated from epidemic outbreaks in neonatal wards. We describe how an extended-spectrum β-lactamase-producing K. pneumoniae (ESBL-KP) outbreak in a neonatal ward was extinguished. During the outbreak, which lasted over two months, 26 neonates were tested for K. pneumoniae , and 42 environmental swabs were taken. Drug susceptibility was determined for the isolated strains, and their virulence and phylogenetic similarity were checked. ESBL-KP colonization was confirmed in 18 neonates, and six were also confirmed to be infected...
December 28, 2022: Antibiotics
https://read.qxmd.com/read/36275054/etiology-and-clinical-characteristics-of-neonatal-sepsis-in-different-medical-setting-models-a-retrospective-multi-center-study
#11
JOURNAL ARTICLE
Yuanqiang Yu, Qingyi Dong, Suping Li, Huaxue Qi, Xin Tan, Hong Ouyang, Jintao Hu, Wen Li, Tao Wang, Yonghui Yang, Xiaoyun Gong, Xiaori He, Pingyang Chen
Objective: General hospitals admit lower gestational age neonates than maternal and child health care centers, therefore associated with a higher morbidity and mortality. This study aimed to assess the etiology and clinical characteristics of neonatal sepsis in different medical setting models. Methods: Neonates admitted to 5 tertiary medical centers, including one national general hospital, two maternal and child health care hospitals and two regional general hospitals, in central-south China with culture-proven sepsis between January 2010 and December 2019 were included in the study...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/36187926/rare-variant-collapsing-analyses-identified-risk-genes-for-neonatal-acute-respiratory-distress-syndrome
#12
JOURNAL ARTICLE
Huiyao Chen, Xiang Chen, Liyuan Hu, Chang Ye, Jiantao Zhang, Guoqiang Cheng, Lin Yang, Yulan Lu, Xinran Dong, Wenhao Zhou
BACKGROUND: Acute respiratory distress syndrome (ARDS) could account for a considerable proportion of neonatal death, while the genetic etiology and pathophysiology of neonatal ARDS remain elusive. In this case-control study, 515 neonates were enrolled in the China Neonatal Genomes Project (CNGP, NCT03931707) from August 2016 to June 2021, including 196 ARDS and 319 non-ARDS matched by sex, gestational age, birth weight, perinatal asphyxia, pneumonia, sepsis, and necrotizing enterocolitis...
2022: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/36169007/lung-ultrasound-to-diagnose-infectious-pneumonia-of-newborns-a-prospective-multicenter-study
#13
JOURNAL ARTICLE
Hai-Ran Ma, Bi-Ying Deng, Jing Liu, Peng Jiang, Yan-Lei Xu, Xiu-Yun Song, Jie Li, Li-Han Huang, Ling-Yun Bao, Rui-Yan Shan, Wei Fu
INTRODUCTION: Whether lung ultrasound (LUS) can be used for pathogenic diagnosis remains controversial. This study was conducted to clarify whether ultrasound has diagnostic value for etiology. METHODS: A total of 135 neonatal pneumonia patients with an identified pathogen were enrolled from the newborn intensive care units of 10 tertiary hospitals in China. The study ran from November 2020 to December 2021. The infants were divided into various groups according to pathogens, time of infection, gestational age, and disease severity...
September 28, 2022: Pediatric Pulmonology
https://read.qxmd.com/read/36062911/fetoplacental-pathology-of-equine-abortion-premature-birth-and-neonatal-loss-due-to-chlamydia-psittaci
#14
JOURNAL ARTICLE
Angela P Begg, Joan Carrick, Catherine Chicken, Anna Blishen, Kristen Todhunter, Kieran Eamens, Cheryl Jenkins
This report describes the fetoplacental pathology of Chlamydia psittaci- associated abortion, premature birth, and neonatal loss in 46 of 442 equine abortion investigations between 2015 and 2019. Seven abortions, 26 premature births, and 13 neonatal deaths with positive C. psittaci polymerase chain reaction (PCR) were evaluated. In 83% of cases (38/46), C. psittaci infection was considered as the primary cause of loss based on quantitative PCR (qPCR) confirmation, pathological findings, and exclusion of other causes, and was supported by Chlamydia spp immunolabeling in fetoplacental lesions...
September 5, 2022: Veterinary Pathology
https://read.qxmd.com/read/35922194/-clinical-characteristics-of-14-cases-of-neonatal-tracheotomy-in-neonatal-intensive-care-unit
#15
JOURNAL ARTICLE
J W Weng, J Yu, F Jin, Y G Peng, J J Zhou, Y Chen, J Zhang, M Y Hei
Objective: To analyze the clinical characteristics of neonatal tracheotomy in neonatal intensive care unit (NICU). Methods: This single-center retrospective study included 14 neonates admitted to NICU of Beijing Children's Hospital, Capital Medical University from January 2016 to August 2021, and were<28 days of age on admission, who met the criteria of tracheotomy and finally completed the procedure. The clinical characteristics including age, weight, duration of ventilation, etiology of tracheotomy, length of hospital stay and prognosis were summarized and analyzed...
August 2, 2022: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/35922186/-value-of-metagenomic-next-generation-sequencing-in-the-etiology-diagnosis-of-bacterial-meningitis-in-children
#16
JOURNAL ARTICLE
Z X Wang, X Wu, J Xu, Y Z Ye, S Z Han, L J Ye, B B Wu, C Q Wang, H Yu
Objective: To explore the value of metagenomic next-generation sequencing (mNGS) in the etiology diagnosis of bacterial meningitis in children. Methods: The etiological results of 189 children diagnosed with "bacterial meningitis" or "purulent meningitis" or "central nervous system infection" in the Children's Hospital of Fudan University from 1st January 2019 to 31st December 2020 were analyzed retrospectively. The cerebrospinal fluid (CFS) of the children with bacterial meningitis was detected by culture and mNGS respectively, and the difference of pathogen detection rate between the 2 methods was analyzed...
August 2, 2022: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/35837238/ventilator-associated-pneumonia-in-neonates-admitted-to-a-tertiary-care-nicu-in-bulgaria
#17
JOURNAL ARTICLE
Vanya R Rangelova, Ralitsa D Raycheva, Ani K Kevorkyan, Maya B Krasteva, Yordan I Kalchev
Ventilator-associated pneumonia (VAP) is the second most common hospital-acquired infection (HAI) among neonatal patients in the intensive care units (ICUs) and is a serious challenge for neonatologists because it affects critically ill patients who need prolonged mechanical ventilation. In Bulgaria, there is no detailed data at regional and national levels on the characteristics of VAP in newborns, which imposes a necessity for specific studies of risk factors and etiology of VAP. The aim of the study was to analyze the frequency, characteristics and risk factors for the occurrence of VAP in newborns hospitalized in intensive care unit...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35678072/polymicrobial-acute-suppurative-parotitis-in-a-33-day-old-infant-a-case-report-and-review-of-the-literature
#18
JOURNAL ARTICLE
D Paouris, T Dallos, V Pitiriga
BACKGROUND: Acute suppurative parotitis (ASP) of neonates is a rare condition characterized by irritability, erythema, and tenderness of the affected gland. METHODS/RESULTS: Only few cases have been reported in Engilsh literature, mostly in male neonates, in a unilateral fashion. In our case, a polymicrobial etiology ( Klebsiella pneumoniae, Staphylococcus aureus, Acinetobacter ursingii , and Acinetobacter junii ) was found. Based on the review of the microbiological findings of cases of ASP in English literature for the years 1970 to 2020, S...
June 9, 2022: Clinical Pediatrics
https://read.qxmd.com/read/35401464/diagnosis-and-surveillance-of-neonatal-infections-by-metagenomic-next-generation-sequencing
#19
JOURNAL ARTICLE
Rong Zhang, Yan Zhuang, Zheng-Hui Xiao, Cai-Yun Li, Fan Zhang, Wei-Qing Huang, Min Zhang, Xiao-Ming Peng, Chao Liu
Microbial infections cause significant morbidity and mortality in neonates. Metagenomic next-generation sequencing is a hypothesis-free and culture-free test that enables broad identification of pathogens and antimicrobial resistance genes directly from clinical samples within 24 h. In this study, we used mNGS for etiological diagnosis and monitoring the efficacy of antibiotic treatment in a cohort of neonatal patients with severe infections. The median age was 19.5 (3-52) days, median gestational age was 37...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/35020289/experience-in-the-diagnosis-of-group-b-streptococcus-infections-in-pregnant-women-and-newborns-in-a-perinatal-center
#20
JOURNAL ARTICLE
Elena Vital Evna Naumkina, E N Kravchenko, L V Kuklina
Serogroup B streptococci (Streptococcus agalactiae) are one of the main etiological agents responsible for the occurrence of severe perinatal infections in both postpartum women and newborns. The experience of microbiological diagnostics of infections caused by streptococcus serogroup B (GBS) according to the data of the microbiological laboratory of the perinatal center is generalized. In the study of biomaterial from patients, the proportion of positive cultures of Streptococcus agalactiae was 2.2% in cervical samples, 8...
December 21, 2021: Klinicheskaia Laboratornaia Diagnostika
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