keyword
https://read.qxmd.com/read/38493358/a-loss-of-function-mutation-in-cldn25-causing-pelizaeus-merzbacher-like-leukodystrophy
#21
JOURNAL ARTICLE
Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell
Claudin-25 (CLDN-25), also known as Claudin containing domain 1, is an uncharacterized claudin family member. It has less conserved amino acid sequences when compared to other claudins. It also has a very broad tissue expression profile and there is currently a lack of functional information from murine knockout models. Here, we report a de novo missense heterozygous variant in CLDN25 (c. 745G>C, p. A249P) found in a patient diagnosed with Pelizaeus-Merzbacher-like leukodystrophy and presenting with symptoms such as delayed motor development, several episodes of tonic absent seizures and generalized dystonia...
March 17, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38493048/plasma-membrane-damage-is-a-new-trigger-of-cellular-senescence
#22
JOURNAL ARTICLE
Nadine Martin, Céline Margand, David Bernard
By blocking proliferation and inducing a secretory phenotype, cellular senescence has beneficial and deleterious effects, the latter being linked to aging. Suda et al. recently reported that plasma membrane (PM) damage (PMD) triggers senescence, suggesting that PMD inducers promote senescence and that the PMD repair machinery can regulate it.
March 15, 2024: Trends in Cell Biology
https://read.qxmd.com/read/38490821/identifying-trusted-local-sources-and-predicting-behavior-change-pathways-according-to-covid-19-vaccination-status-results-of-a-2022-statewide-survey-of-alaskan-adults
#23
JOURNAL ARTICLE
Drew B Cameron, Laura Grage, Rebecca Van Wyck, Alexandra Edwards, Joy Chavez Mapaye, Ann Cheng, Gabriel Garcia
BACKGROUND: Low rates of COVID-19 vaccination remain a substantial public health challenge. Despite early successes, vaccinations of Alaskans trail the US average, drawing attention to the need for better-designed and targeted vaccine confidence interventions. Our objective was to assess levels of community trust and theory-driven predictors of vaccination status to inform the design of future programs. METHODS: We conducted a cross-sectional, telephone-based survey of 940 Alaskan adults between May and June 2022...
March 14, 2024: Vaccine
https://read.qxmd.com/read/38489735/evaluation-of-chatgpt-in-providing-appropriate-fracture-prevention-recommendations-and-medical-science-question-responses-a-quantitative-research
#24
JOURNAL ARTICLE
Jiahao Meng, Ziyi Zhang, Hang Tang, Yifan Xiao, Pan Liu, Shuguang Gao, Miao He
Currently, there are limited studies assessing ChatGPT ability to provide appropriate responses to medical questions. Our study aims to evaluate ChatGPT adequacy in responding to questions regarding osteoporotic fracture prevention and medical science. We created a list of 25 questions based on the guidelines and our clinical experience. Additionally, we included 11 medical science questions from the journal Science. Three patients, 3 non-medical professionals, 3 specialist doctor and 3 scientists were involved to evaluate the accuracy and appropriateness of responses by ChatGPT3...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38486184/pharmacological-labour-pain-interventions-south-african-midwives-perspective
#25
JOURNAL ARTICLE
L E Parkies, D Murray, U B Okafor
Women of childbearing age feel great about giving birth, but the pain could be excruciating depending on their pain tolerances. Midwives requires obstetrical knowledge and skills such as pain management during labour and safety. We explored midwives' perspectives on the utilisation of pharmacological pain alleviation interventions during labour in selected hospitals in Matjhabeng Municipality, Free State province, South Africa. A qualitative study was undertaken, involving a sample of ten midwives, using a semi-structured interview guide...
March 14, 2024: BMC Nursing
https://read.qxmd.com/read/38486065/assessing-the-impact-of-post-mortem-damage-and-contamination-on-imputation-performance-in-ancient-dna
#26
JOURNAL ARTICLE
Antonio Garrido Marques, Simone Rubinacci, Anna-Sapfo Malaspinas, Olivier Delaneau, Bárbara Sousa da Mota
Low-coverage imputation is becoming ever more present in ancient DNA (aDNA) studies. Imputation pipelines commonly used for present-day genomes have been shown to yield accurate results when applied to ancient genomes. However, post-mortem damage (PMD), in the form of C-to-T substitutions at the reads termini, and contamination with DNA from closely related species can potentially affect imputation performance in aDNA. In this study, we evaluated imputation performance (i) when using a genotype caller designed for aDNA, ATLAS, compared to bcftools, and (ii) when contamination is present...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38485833/corpse-or-not-two-peculiar-cases-of-misidentification
#27
JOURNAL ARTICLE
S Plenzig, J Helmus, M Weber, M A Verhoff, V Hachmann
Irrespective of whether they are intended for collectors or for the fetish market, dolls are being produced to look more and more realistic with such a degree of life-like detail that they can be mistaken for a real person. This paper reports two cases of misidentification due to this increasing similarity: In the first case, a sex doll was mistaken for a corpse; in the second case, a corpse was mistaken for a doll. While in the latter case, only medical laypersons were at the discovery site, in the first case, an emergency doctor had issued a medical certificate of death for the purported corpse...
March 15, 2024: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/38483451/quality-and-dependability-of-chatgpt-and-dingxiangyuan-forums-for-remote-orthopedic-consultations-comparative-analysis
#28
JOURNAL ARTICLE
Zhaowen Xue, Yiming Zhang, Wenyi Gan, Huajun Wang, Guorong She, Xiaofei Zheng
BACKGROUND: The widespread use of artificial intelligence, such as ChatGPT (OpenAI), is transforming sectors, including health care, while separate advancements of the internet have enabled platforms such as China's DingXiangYuan to offer remote medical services. OBJECTIVE: This study evaluates ChatGPT-4's responses against those of professional health care providers in telemedicine, assessing artificial intelligence's capability to support the surge in remote medical consultations and its impact on health care delivery...
March 14, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38482452/construction-and-validation-of-a-novel-web-based-nomogram-for-primary-ocular-adnexal-lymphoma-a-real-world-analysis-based-on-the-surveillance-epidemiology-and-end-results-database
#29
JOURNAL ARTICLE
Zhen Chen, Ling Ye, Xia Li
BACKGROUND: The occurrence rate of primary ocular adnexal lymphoma (POAL) is relatively low, and estimation of prognosis of these patients poses significant challenges. This study aims to investigate the independent prognostic factors of POAL patients and establish a predictive model to provide clinical data for the formulation of standardized treatment plans. METHODS: We conducted a retrospective analysis by extracting data of POAL patients diagnosed between 2000 and 2017 from the Surveillance, Epidemiology, and End Results (SEER) database...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38481232/descriptive-feedback-with-targeted-education-to-improve-telephonic-escalation-of-care-a-simulation-based-study
#30
JOURNAL ARTICLE
Aster Kuriakose, Subodhini Puhambugoda Arachchige, Theophilus I Emeto, Matthew I Hiskens, Gopakumar Hariharan
BACKGROUND: Awareness of communication failures in healthcare has necessitated the implementation of standardized, validated handover tools such as Identification, Situation, Background, Assessment, Recommendation (ISBAR). Although educational sessions improve communication, the effectiveness of individualized care escalation communication training is unknown. The primary aim was to conduct a simulation-based study to assess individualized one-on-one communication training for junior medical doctors for improving care escalation in pediatric emergencies...
March 13, 2024: BMC Medical Education
https://read.qxmd.com/read/38478573/application-of-artificial-neural-networks-to-evaluate-femur-development-in-the-human-fetus
#31
JOURNAL ARTICLE
Anna Badura, Mariusz Baumgart, Magdalena Grzonkowska, Mateusz Badura, Piotr Janiewicz, Michał Szpinda, Adam Buciński
The present article concentrates on an innovative analysis that was performed to assess the development of the femur in human fetuses using artificial intelligence. As a prerequisite, linear dimensions, cross-sectional surface areas and volumes of the femoral shaft primary ossification center in 47 human fetuses aged 17-30 weeks, originating from spontaneous miscarriages and preterm deliveries, were evaluated with the use of advanced imaging techniques such as computed tomography and digital image analysis...
2024: PloS One
https://read.qxmd.com/read/38475848/knowledge-attitudes-and-practices-among-medical-workers-toward-outpatient-diabetes-information-platform
#32
JOURNAL ARTICLE
Yi Peng, Jianying Duan, Jian Hou, Nan Xu, Jiaming Wu, Xijing Bao, Qian Yao, Yang Li
BACKGROUND: This study aimed to assess the knowledge, attitudes and practices among medical workers toward outpatient diabetes information platform. METHODS: This web-based cross-sectional study was conducted between May 2023 and June 2023 at the First Hospital of Zhangjiakou, China. A self-designed questionnaire was developed to collect demographic information of medical workers, and assess their knowledge, attitudes and practices toward outpatient diabetes information platform...
March 12, 2024: BMC Health Services Research
https://read.qxmd.com/read/38472600/an-ai-healthcare-ecosystem-framework-for-covid-19-detection-and-forecasting-using-cronasona
#33
REVIEW
Samah A Z Hassan
The primary purpose of this paper is to establish a healthcare ecosystem framework for COVID-19, CronaSona. Unlike some studies that focus solely on detection or forecasting, CronaSona aims to provide a holistic solution, for managing data and/or knowledge, incorporating detection, forecasting, expert advice, treatment recommendations, real-time tracking, and finally visualizing results. The innovation lies in creating a comprehensive healthcare ecosystem framework and an application that not only aids in COVID-19 diagnosis but also addresses broader health challenges...
March 13, 2024: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/38472005/consumer-focus-group-testing-with-stakeholders-to-generate-an-enteral-resuscitation-training-flipbook-for-primary-health-center-and-first-level-hospital-providers-in-nepal
#34
JOURNAL ARTICLE
Stephanie Francalancia, Kajal Mehta, Raslina Shrestha, Diwakar Phuyal, Das Bikash, Manish Yadav, Kiran Nakarmi, Shankar Rai, Sam Sharar, Barclay T Stewart, Gary Fudem
INTRODUCTION: Enteral resuscitation (EResus) is operationally advantageous to intravenous resuscitation for burn-injured patients in some low-resource settings. However, there is minimal guidance and no training materials for EResus tailored to non-burn care providers. We aimed to develop and consumer-test a training flipbook with doctors and nurses in Nepal to aid broader dissemination of this life-saving technique. MATERIALS AND METHODS: We used individual cognitive interviews with Nepali (n = 12) and international (n = 4) burn care experts to define key elements of EResus and specific concepts for its operationalization at primary health centers and first-level hospitals in Nepal...
February 15, 2024: Burns
https://read.qxmd.com/read/38466675/knowledge-attitudes-and-practices-towards-childhood-tuberculosis-among-healthcare-workers-at-two-primary-health-facilities-in-lusaka-zambia
#35
JOURNAL ARTICLE
Paul Chabala Kaumba, Daniel Siameka, Mary Kagujje, Chalilwe Chungu, Sarah Nyangu, Nsala Sanjase, Minyoi Mubita Maimbolwa, Brian Shuma, Lophina Chilukutu, Monde Muyoyeta
BACKGROUND: Zambia is among the 30 high-burden countries for tuberculosis (TB), Human Immunodeficiency Virus (HIV)-associated TB, and multi-drug resistant/rifampicin resistant TB with over 5000 children developing TB every year. However, at least 32% of the estimated children remain undiagnosed. We assessed healthcare workers' (HCWs) knowledge, attitudes, and practices (KAP) towards childhood TB and the factors associated with good KAP towards childhood TB. METHODS: Data was collected at two primary healthcare facilities in Lusaka, Zambia from July to August 2020...
2024: PloS One
https://read.qxmd.com/read/38463405/approach-to-sudden-hearing-loss-among-primary-care-physicians-in-riyadh-saudi-arabia
#36
JOURNAL ARTICLE
Nader F Aldajani, Abdulrahman M Aloufi, Nujud A Binhudayb, Buthaina J Yahya, Abdullah F Alkarni
INTRODUCTION: A medical emergency known as sudden sensorineural hearing loss (SSNHL) affects the ears suddenly, has a considerable probability of negative cognitive and functional outcomes, and can influence the patient's quality of life. Primary care physicians play a crucial role in diagnosing SSNHL and initiating prompt and efficient management since they are the ones who would likely encounter it initially. This study aims to evaluate the present knowledge, diagnostic, and management perspective of SSNHL among primary care physicians in Riyadh, Saudi Arabia...
March 2024: Curēus
https://read.qxmd.com/read/38457545/why-patients-self-refer-to-the-emergency-service-for-nonurgency-a-mix-method-survey-from-a-family-medicine-perspective
#37
JOURNAL ARTICLE
Canan Tuz, Alis Özçakir
The definition of "nonurgent emergency service visits" is visits to conditions for medical conditions that require attention but are not life-threatening immediately or severe enough to require urgent intervention. This study aims to investigate the reasons why patients choose to self-refer to the emergency service (ES) instead of their primary care health center for nonurgent complaints. The study was carried out in a tertiary hospital. The survey consisted of 2 parts with sociodemographic questions, knowledge of their family physician, and the reason why it has been applied to the ES with multiple choice answers...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456456/evaluating-health-systems-efficiency-towards-universal-health-coverage-a-data-envelopment-analysis
#38
JOURNAL ARTICLE
Paul Eze, Chidumebi Judith Idemili, Lucky Osaheni Lawani
To estimate the technical efficiency of health systems toward achieving universal health coverage (UHC) in 191 countries. We applied an output-oriented data envelopment analysis approach to estimate the technical efficiency of the health systems, including the UHC index (a summary measure that captures both service coverage and financial protection) as the output variable and per capita health expenditure, doctors, nurses, and hospital bed density as input variables. We used a Tobit simple-censored regression with bootstrap analysis to observe the socioeconomic and environmental factors associated with efficiency estimates...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://read.qxmd.com/read/38450110/japan-s-healthcare-delivery-system-from-its-historical-evolution-to-the-challenges-of-a-super-aged-society
#39
REVIEW
Teruyuki Katori
Although Japan's healthcare delivery system is highly regarded internationally, the COVID-19 pandemic has exposed its structural problems. Behind these issues lies a history of medical care provisions supported mainly by an unrestricted, "free labeling" system, and independently financed private hospitals. In addition, patients have a high degree of freedom of choice under the Japanese medical insurance system, making it difficult to provide comprehensive and continuous health management from initial diagnosis and treatment (primary care), specialized treatment, to supporting a return to home, providing nursing care and lifestyle support...
February 29, 2024: Global health & medicine
https://read.qxmd.com/read/38445639/dealing-with-fibromyalgia-in-the-family-context-a-qualitative-description-study
#40
JOURNAL ARTICLE
Luz de Myotanh Vázquez Canales, Inmaculada Pereiró Berenguer, Eduardo Aguilar García-Iturrospe, Charo Rodríguez
Headings purpose: Fibromyalgia (FM) is a chronic, nondegenerative disease with important limitations in patients. Its average global prevalence is 1.78%, and women are more affected than men (3:1). Due to the lack of objective diagnostic tools, it is a complex medical condition that is frequently unseen by patients' relatives and doctors, which might nonetheless have a noticeable impact on the patient's entourage. Material and Methods: This qualitative descriptive study aimed to elicit family members' views on how FM affects their lives...
March 6, 2024: Scandinavian Journal of Primary Health Care
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