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https://www.readbyqxmd.com/read/28079849/role-of-serial-f-18-fdg-pet-ct-scans-in-assessing-treatment-response-and-predicting-relapses-in-patients-with-symptomatic-sarcoidosis
#1
Venkata Nagarjuna Maturu, Sampanna Jung Rayamajhi, Ritesh Agarwal, Ashutosh Nath Aggarwal, Dheeraj Gupta, Bhagwant Rai Mittal
: ackground: Monitoring disease activity in sarcoidosis remains a clinical challenge as there is no gold standard. Positron emission tomography (PET) imaging is a novel tool to assess the metabolic activity. There is limited data on the role of serial PET scans in monitoring the disease activity. METHODS: This is a prospective study of 27 sarcoidosis patients treated with systemic corticosteroids. Patients underwent two serial PET/CT scans: one before initiating therapy and the follow up scan at end of therapy...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28077725/encoding-of-both-reaching-and-grasping-kinematics-in-dorsal-and-ventral-premotor-cortices
#2
Kazutaka Takahashi, Matthew D Best, Noah Huh, Kevin A Brown, Adil A Tobaa, Nicholas G Hatsopoulos
: Classically, it has been hypothesized that reach-to-grasp movements arise from two discrete parieto-frontal cortical networks. As part of these networks, the dorsal premotor cortex has been implicated in the control of reaching movements of the arm, while the ventral premotor cortex has been associated with the control of grasping movements of the hand. Recent studies have shown that such a strict delineation of function along anatomical boundaries is unlikely partly because reaching to different locations can alter distal hand kinematics and grasping different objects can affect kinematics of the proximal arm; Here, we used chronically implanted multi-electrode arrays to record unit spiking activity in both PMd and PMv simultaneously while rhesus macaques engaged in a reach-to-grasp task...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28067697/national-administrative-databases-in-adult-spinal-deformity-surgery-a-cautionary-tale
#3
Aaron J Buckland, Gregory Poorman, Robert Freitag, Cyrus Jalai, Eric O Klineberg, Michael Kelly, Peter G Passias
STUDY DESIGN: Comparison between national administrative databases and a prospective multicenter physician managed database. OBJECTIVES: This study aims to assess the applicability of National Administrative Databases (NADs) in Adult Spinal Deformity (ASD). Our hypothesis is that NADs do not include comparable patients as in a physician-managed database (PMD) for surgical outcomes in adult spinal deformity. SUMMARY OF BACKGROUND DATA: NADs such as National Inpatient Sample (NIS) and National Surgical Quality Improvement Program (NSQIP) provide large numbers of publications owing to ease of data access and lack of IRB approval requirement...
January 6, 2017: Spine
https://www.readbyqxmd.com/read/28060006/resolving-epibole-with-polymeric-membrane-dressings-in-home-care
#4
Kimberly S Bare, Jerri Drain
BACKGROUND: The management of chronic (nonhealing) wounds with epibole is challenging and costly, especially when the problem is not promptly identified or the patient is intolerant to conventional treatments. CASE DESCRIPTION: We describe the use of a polymeric membrane dressing (PMD) in 3 patients with chronic (nonhealing) wounds and epibole who were unable to be treated with traditional interventions such as silver nitrate or sharp debridement. Patient 1 was a 51 year-old male with a right foot stasis ulcer with 60% fibrin/slough to the wound bed, patient 2 was a 58-year-old female with a stage 4 pressure injury of the left hip with undermining, and patient 3 was a 62-year-old female with a dehisced abdominal surgical wound...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28059352/single-channel-5-12-tbit-s-1-28-tbaud-dqpsk-transmission-over-300-km-using-non-coherent-nyquist-pulses
#5
Daiki Suzuki, Koudai Harako, Toshihiko Hirooka, Masataka Nakazawa
We present a single-channel 5.12 Tbit/s polarization-multiplexed DQPSK transmission over 300 km at 1.28 Tbaud using a non-coherent Nyquist pulse. An ultrafast OTDM demultiplexer for 1.28 Tbaud Nyquist pulses was newly developed with a mode-locked fiber laser operating in the L band as a control pulse source. Thanks to the high PMD tolerance of Nyquist pulses, a 300 km transmission was successfully demonstrated for the first time at such a high symbol rate.
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28047403/su-f-j-224-impact-of-4d-pet-ct-on-percist-classification-of-lung-and-liver-metastases-in-nslc-and-colorectal-cancer
#6
J Meier, B Lopez, O Mawlawi
PURPOSE: To quantify the impact of 4D PET/CT on PERCIST metrics in lung and liver tumors in NSCLC and colorectal cancer patients. METHODS: 32 patients presenting lung or liver tumors of 1-3 cm size affected by respiratory motion were scanned on a GE Discovery 690 PET/CT. The bed position with lesion(s) affected by motion was acquired in a 12 minute PET LIST mode and unlisted into 8 bins with respiratory gating. Three different CT maps were used for attenuation correction: a clinical helical CT (CT_clin), an average CT (CT_ave), and an 8-phase 4D CINE CT (CT_cine)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046598/su-f-t-334-has-imrt-changed-the-impact-of-mlc-leaf-width-a-systematic-review-and-meta-analysis-of-tps-studies
#7
M Luzzara, L Santoro, K Brown
PURPOSE: We have performed a systematic review and meta-analysis in order to compare MLC leaf width used for different treatment techniques such as conformal and IMRT. METHODS: Medline and Google scholar databases have been searched using the "MLC leaf width" keywords with a cut-off date of 31st December 2015, considering only peer-reviewed papers. We have defined as intervention the MLC leaf width of 5 and 2.5 mm. We used the Conformity Index (CI) as the outcome subjected to the analysis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042027/distant-heterotopic-callosal-connections-to-premotor-cortex-in-non-human-primates
#8
F Lanz, V Moret, R Ambett, C Cappe, E M Rouiller, G Loquet
Cortico-cortical connectivity has become a major focus of neuroscience in the last decade but most of the connectivity studies focused on intrahemispheric circuits. Little has been reported about information acquired and processed in the premotor cortex and its functional connection with its homotopic counterpart in the opposite hemisphere via the corpus callosum. In non-human primates (macaques) lateralization is not well documented and its exact role is still unknown. The present study confirms in two macaques the existence of homotopic contralateral projections and completes the picture by further exploring heterotopic (non-motor) callosal projections...
December 30, 2016: Neuroscience
https://www.readbyqxmd.com/read/28028140/comparative-evaluation-of-a-silicone-membrane-as-an-alternative-to-skin-for-testing-mosquito-repellents
#9
Natasha M Agramonte, Salvador A Gezan, Ulrich R Bernier
Repellents prevent mosquito bites and help reduce mosquito-borne disease, a global public health issue. Laboratory-based repellent bioassays predict the ability of compounds to deter mosquito feeding, but the variety of repellent bioassays and statistical analysis methods makes it difficult to compare results across methodologies. The most realistic data are collected when repellents are applied on the skin; however, this method exposes volunteers to chemicals and mosquito bites. Silicone membranes were investigated as an alternative to human skin in assays of repellent efficacy...
December 27, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28018572/placental-methylome-analysis-from-a-prospective-autism-study
#10
Diane I Schroeder, Rebecca J Schmidt, Florence K Crary-Dooley, Cheryl K Walker, Sally Ozonoff, Daniel J Tancredi, Irva Hertz-Picciotto, Janine M LaSalle
BACKGROUND: Autism spectrum disorders (ASD) are increasingly prevalent neurodevelopmental disorders that are behaviorally diagnosed in early childhood. Most ASD cases likely arise from a complex mixture of genetic and environmental factors, an interface where the epigenetic marks of DNA methylation may be useful as risk biomarkers. The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and highly methylated domains (HMDs) reflective of methylation patterns observed in the early embryo...
2016: Molecular Autism
https://www.readbyqxmd.com/read/28005150/early-trends-in-bronchoscopic-lung-volume-reduction-a-systematic-review-and-meta-analysis-of-efficacy-parameters
#11
REVIEW
Abhishek Kumar, Rajany Dy, Kanwaljit Singh, M Jeffery Mador
INTRODUCTION: The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS: Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analysis was performed for the BLVR modalities with ≥3 trials. Of the 18 shortlisted publications, only valves (four trials; n = 159) and coils (six trials; n = 194) qualified for meta-analysis...
December 22, 2016: Lung
https://www.readbyqxmd.com/read/28002200/association-between-expression-of-inflammatory-markers-in-normal-breast-tissue-and-mammographic-density-among-premenopausal-and-postmenopausal-women
#12
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, François Sanschagrin, Alexandre Bureau, Brigitte Poirier, Caroline Diorio
OBJECTIVE: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer and activator of transcription 3) and anti-inflammatory markers (transforming growth factor-β, interleukin 10, and lactoferrin) in normal breast tissue with mammographic density, a strong breast cancer risk indicator, among 163 breast cancer patients...
December 19, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28001243/accuracy-of-clinical-diagnosis-for-the-identification-of-potentially-malignant-disorders-and-malignant-lip-lesions
#13
Marina Curra, Gabriela Salvadori, Roger Junges, Manoel Sant'ana Filho, Fernando Neves Hugo, Manoela Domingues Martins
The aim of this study was to assess the accuracy of clinical diagnosis for lip lesions based on sensitivity and specificity. The retrospective analysis focused on the detection of lesions caused by potentially malignant disorders (PMDs) and malignant lesions (n = 1195). All cases were classified as benign, PMD, and malignant lesions. Concordance between diagnoses based on clinical examination and those based on histopathological analysis was assessed, and accuracy for the identification of PMD and malignant lesions was calculated...
December 22, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/28000061/depression-during-the-menopause-transition-impact-on-quality-of-life-social-adjustment-and-disability
#14
Bathsheba A Wariso, Gioia M Guerrieri, Karla Thompson, Deloris E Koziol, Nazli Haq, Pedro E Martinez, David R Rubinow, Peter J Schmidt
The impact of depression on quality of life (QOL) and social support has neither been well characterized in clinical samples of women with perimenopausal depression (PMD) nor have the relative contributions of depression and other menopausal symptoms (e.g., hot flushes) to declining QOL been clarified. In this study, we compared QOL measures, social support, and functional disability in PMD and non-depressed perimenopausal women. We evaluated women aged 40-60 years who presented with menstrual cycle irregularity, elevated plasma FSH levels, and met criteria for perimenopause...
December 21, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27998850/-subtractive-selex-using-agar-beads-for-screening-dna-aptamers-with-specific-affinity-to-hiv-gp41-antigen
#15
Kun Li, Chen-Lin Xiu, Li-Ming Gao, Ming Shi, Yue Zhai
OBJECTIVE: To obtain DNA aptamers with a highly specific affinity to HIV gp41 antigen using SELEX screening for detection of HIV. METHODS: The specific DNA aptamers of HIV gp41 antigen were screened from the double-stranded DNA derived from the single-stranded DNA (ssDNA) library with agarose beads as the supportive medium and HIV gp41 antigen as the target molecule using SELEX technique and real-time quantitative PCR. RESULTS: The secondary ssDNA library obtained after 6 rounds of screening was amplified by PCR to obtain dsDNA...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27997936/a-review-of-recommendations-on-the-safe-and-effective-use-of-topical-mosquito-repellents
#16
Cameron E Webb, Isabel Mr Hess
Mosquito-borne disease is an annual problem in Australia, with endemic pathogens such as Ross River virus infecting thousands of people each year. The recent emergence of Zika virus in South America and the Pacific, together with ongoing outbreaks of dengue viruses in Southeast Asia, generated great community interest in the most effective strategies to avoid mosquito bites. Large-scale mosquito control programs are not common in Australia and are limited in New South Wales (NSW). The use of topical insect repellents is a key recommendation by health authorities to prevent mosquito-borne disease...
December 14, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27966571/vitamin-d-and-serum-leptin-a-systematic-review-and-meta-analysis-of-observational-studies-and-randomized-controlled-trials
#17
REVIEW
M Hajimohammadi, S Shab-Bidar, T R Neyestani
We aimed to investigate the potential association between vitamin D and serum leptin levels by pooling together the results from observational studies and clinical trials. A systematic literature search of PubMed, Scopus and Google Scholar was conducted up to March 2015. The analysis of observational studies was conducted on six papers that reported nine correlation coefficients using Fisher's Z and its standard error. Then, effect sizes of eligible trials were pooled using random-effects models (the DerSimonian-Laird estimator)...
December 14, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27942912/distinguishing-features-of-psychogenic-functional-versus-organic-hemifacial-spasm
#18
José Fidel Baizabal-Carvallo, Joseph Jankovic
Hemifacial spasm (HFS) is one of the most common presentations in patients with cranial psychogenic (functional) movement disorders (PMD). Medical records and videos of patients with PMD and HFS were reviewed to identify those with psychogenic HFS and to compare the phenomenology of psychogenic HFS with organic HFS. We identified 18 (9.8%) patients with psychogenic HFS from a cohort of 184 patients with PMDs. There were 14 (78%) women and 4 men, with a mean age at onset of 33 ± 13.5 years. These were compared with 37 consecutive patients with organic (primary) HFS...
December 9, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27900250/effect-of-tens-on-stimulation-of-saliva-in-postmenopausal-women-with-or-without-oral-dryness-an-interventional-study
#19
Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta
BACKGROUND: Decreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modalities had been tried with variable results and associated side effects or discomfort. AIM: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females with and without oral dryness...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27882623/concise-review-stem-cell-based-treatment-of-pelizaeus-merzbacher-disease
#20
REVIEW
M Joana Osorio, David H Rowitch, Paul Tesar, Marius Wernig, Martha S Windrem, Steven A Goldman
Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutation in the proteolipid protein-1 (PLP1) gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD exhibits phenotypic variability that reflects its considerable genotypic heterogeneity, but all forms of the disease result in central hypomyelination, associated in most cases with early neurological dysfunction, progressive deterioration, and ultimately death. PMD may present as a connatal, classic and transitional forms, or as the less severe spastic paraplegia type 2 and PLP-null phenotypes...
November 23, 2016: Stem Cells
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