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https://www.readbyqxmd.com/read/27900250/effect-of-tens-on-stimulation-of-saliva-in-postmenopausal-women-with-or-without-oral-dryness-an-interventional-study
#1
Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta
BACKGROUND: Decreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modalities had been tried with variable results and associated side effects or discomfort. AIM: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females with and without oral dryness...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27882623/concise-review-stem-cell-based-treatment-of-pelizaeus-merzbacher-disease
#2
M Joana Osorio, David H Rowitch, Paul Tesar, Marius Wernig, Martha S Windrem, Steven A Goldman
Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutation in the proteolipid protein-1 (PLP1) gene, which encodes the proteolipid protein of myelinating oligodendroglia. PMD exhibits phenotypic variability that reflects its considerable genotypic heterogeneity, but all forms of the disease result in central hypomyelination, associated in most cases with early neurological dysfunction, progressive deterioration, and ultimately death. PMD may present as a connatal, classic and transitional forms, or as the less severe spastic paraplegia type 2 and PLP-null phenotypes...
November 23, 2016: Stem Cells
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#3
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
November 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27857406/joint-cd-and-pmd-monitoring-based-on-a-pair-of-low-bandwidth-coherent-receivers
#4
Yuli Chen, Qi Sui, Zhaohui Li, Zihao Liang, Weiping Liu
A joint chromatic dispersion (CD) and 1st order polarization mode dispersion (PMD) monitoring technique for both a coherent and a non-coherent single carrier system based on a pair of cost effective low-bandwidth coherent receivers is proposed and experimentally demonstrated. By jointly detecting the narrow band around ± 1/2 baud rate, the CD and PMD can be estimated simultaneously by time domain correlation and Stokes space rotational angle recovery, respectively. The CD estimation range is theoretically infinite and the PMD estimation range is limited to the maximum of 1/2 symbol period...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27852735/trial-to-trial-adjustments-of-speed-accuracy-tradeoffs-in-premotor-and-primary-motor-cortex
#5
David Thura, Guido Guberman, Paul Cisek
Recent studies have shown that activity in sensorimotor structures varies depending on the speed-accuracy trade-off (SAT) context in which a decision is made. Here, we test the hypothesis that the same areas also reflect a more local adjustment of SAT established between individual trials, based on the outcome of the previous decision. Two monkeys performed a reaching decision task in which sensory evidence continuously evolves during the time course of a trial. In two SAT contexts, we compared neural activity in trials following a correct choice versus those following an error...
November 16, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27844565/depressive-symptomatology-after-spinal-cord-injury-a-multi-center-investigation-of-multiple-racial-ethnic-groups
#6
Yue Cao, Chao Li, Anne Gregory, Susan Charlifue, James S Krause
OBJECTIVE: To identify (1) racial-ethnic differences in depressive symptomatology after spinal cord injury (SCI) and (2) the relationship of multiple additional factors to depressive symptoms, including health behaviors, employment, fatigue, and pain interference. DESIGN: Cross-sectional Setting: Data were collected at 3 specialty hospitals in different regions of the USA (Southeastern, Mountain, Western). PARTICIPANTS: Participants (N = 1,063) were identified from outpatient records of the 3 hospitals with oversampling of racial-ethnic minority groups...
November 15, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27832654/predictive-and-prognostic-value-of-early-disease-progression-by-pet-evaluation-in-advanced-non-small-cell-lung-cancer
#7
Giuseppe Luigi Banna, Giuseppe Anile, Giorgio Russo, Paolo Vigneri, Marine Castaing, Maurizio Nicolosi, Salvatore Strano, Stefania Gieri, Rosaria Spina, Domenico Patanè, Giacomo Calcara, Filippo Fraggetta, Francesco Marletta, Alessandro Stefano, Massimo Ippolito
OBJECTIVE: To assess the predictive and prognostic value of progressive metabolic disease (PMD) by the use of early 18Fluorodeoxyglucose positron emission tomography (18FDG-PET) in patients with clinical stage IV non-small cell lung cancer (NSCLC) treated with first-line chemotherapy. METHODS: An 18FDG-PET performed following the first cycle of chemotherapy (PET-1) was compared with a pretreatment 18FDG-PET (PET-0) and a computed tomography (CT) scan after the third cycle (CT-3)...
November 11, 2016: Oncology
https://www.readbyqxmd.com/read/27832607/role-of-human-premotor-dorsal-region-in-learning-a-conditional-visuo-motor-task
#8
Pranav J Parikh, Marco Santello
Conditional learning is an important component of our everyday activities, e.g. handling a phone or sorting work files and requires identification of the arbitrary stimulus, accurate selection of the motor response, monitoring of the response, and storing in memory the stimulus-response association for future recall. Learning this type of conditional visuo-motor task appears to engage the premotor dorsal region (PMd). However, the extent to which PMd might be involved in specific or all processes of conditional learning is not well understood...
November 2, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27828487/joint-tracking-and-equalization-scheme-for-multi-polarization-effects-in-coherent-optical-communication-systems
#9
Yiqiao Feng, Linqian Li, Jiachuan Lin, Hengying Xu, Wenbo Zhang, Xianfeng Tang, Lixia Xi, Xiaoguang Zhang
We propose a joint multi-polarization-effect tracking and equalization method based on two extended Kalman filters, which can cope with state of polarization (SOP) tracing, polarization demultiplexing, equalization for polarization dependent loss (PDL) and polarization mode dispersion (PMD) in PDM-M-QAM coherent optical communication system. The mathematical model of the proposed method is given and analyzed in detail. Through simulation, the proposed method is proved to be very effective in a 28 Gbaud/s PDM-16QAM system...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27828151/four-step-shear-method-for-the-absolute-measurement-of-a-flat-surface-based-on-phase-measuring-deflectometry
#10
Kewei E, Dahai Li, Chen Zhang, Tao Zhang, Mengyang Li, Qin Wang, Chengying Jin, Zhao Xiong
This paper proposes a new shearing approach to eliminate the systematic errors in phase measuring deflectometry (PMD). Besides a normal measurement using PMD, another three measurements are taken when the test surfaces are translated and rotated with an amount of known magnitude in our proposed method. The four measurements give three sheared wavefronts, and then the difference Zernike polynomial fitting and a least squares algorithm are proposed to reconstruct the true test surface figure. The proposed method is demonstrated and verified through computer simulation and experimental results...
October 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27826107/increased-functional-connectivity-one-week-after-motor-learning-and-tdcs-in-stroke-patients
#11
Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, Yves Vandermeeren
Recent studies using resting-state functional magnetic resonance imaging (rs-fMRI) demonstrated that changes in functional connectivity (FC) after stroke correlate with recovery. The aim of this study was to explore whether combining motor learning to dual transcranial direct current stimulation (dual-tDCS, applied over both primary motor cortices (M1)) modulated FC in stroke patients. Twenty-two chronic hemiparetic stroke patients participated in a baseline rs-fMRI session. One week later, dual-tDCS/sham was applied during motor skill learning (intervention session); one week later, the retention session started with the acquisition of a run of rs-fMRI imaging...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27807519/observation-of-implied-motion-in-a-work-of-art-modulates-cortical-connectivity-and-plasticity
#12
Carmen Concerto, Carmenrita Infortuna, Ludovico Mineo, Manuel Pereira, David Freedberg, Eileen Chusid, Eugenio Aguglia, Fortunato Battaglia
Following the discovery of mirror neurons, much attention has been de-voted to understanding the neural responses evoked by observation of implied motion in works of art. Neuroimaging studies have demonstrated that dorsal premotor cortex (PMd) is commonly involved during observation of movements but the role of the inhibitory and excitatory connections between PMd and primary motor cortex (M1) during observation of implied motion remains uncertain. In this study, using high and low frequency repetitive transcranial magnetic stimulation (rTMS), we examined PMd-M1 connectivity and plasticity during observation of Michelangelo's frescos with and without implied motion (Sistine Chapel, 1508-1512)...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27801896/alterations-in-amygdala-prefrontal-circuits-in-infants-exposed-to-prenatal-maternal-depression
#13
J Posner, J Cha, A K Roy, B S Peterson, R Bansal, H C Gustafsson, E Raffanello, J Gingrich, C Monk
Prenatal exposure to maternal depression is common and puts offspring at risk for developing a range of neuropsychiatric disorders. Despite its prevalence and adverse associations, neurobiological processes by which prenatal maternal depression (PMD) confers risk remain poorly understood. Maternal mood and fetal behavior were assessed between 34 and 37 gestational weeks. Using resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI, we examined functional and structural connectivity within amygdala-prefrontal circuits in 64 infants (mean age=5...
November 1, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27793435/a-novel-plp1-mutation-associated-with-optic-nerve-enlargement-in-two-siblings-with-pelizaeus-merzbacher-disease-a-new-mri-finding
#14
Efterpi Pavlidou, Vijaya Ramachandran, Veronica Govender, Clare Wilson, Rini Das, Victoria Vlachou, Evangelos Pavlou, Anand Saggar, Kshitij Mankad, Maria Kinali
Pelizaeus-Merzbacher disease (PMD) is a rare, X-linked disorder characterized by hypomyelination of the Central Nervous System due to mutations in the PLP1 gene. Certain mutations of the PLP1 gene correlate with specific clinical phenotypes and neuroimaging findings. We herein report a novel mutation of the PLP1 gene in two siblings with PMD associated with a rare and protean neuroimaging finding of optic nerve enlargement. To the best of our knowledge this is the first time that this novel mutation H133P of PLP1 gene is identified and clinically associated with optic nerve enlargement in PMD patients...
October 25, 2016: Brain & Development
https://www.readbyqxmd.com/read/27761519/the-largest-response-component-in-the-motor-cortex-reflects-movement-timing-but-not-movement-type
#15
Matthew T Kaufman, Jeffrey S Seely, David Sussillo, Stephen I Ryu, Krishna V Shenoy, Mark M Churchland
Neural activity in monkey motor cortex (M1) and dorsal premotor cortex (PMd) can reflect a chosen movement well before that movement begins. The pattern of neural activity then changes profoundly just before movement onset. We considered the prediction, derived from formal considerations, that the transition from preparation to movement might be accompanied by a large overall change in the neural state that reflects when movement is made rather than which movement is made. Specifically, we examined "components" of the population response: time-varying patterns of activity from which each neuron's response is approximately composed...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27737355/assessment-of-serum-copper-iron-and-immune-complexes-in-potentially-malignant-disorders-and-oral-cancer
#16
Ritu Tiwari, Chaya Manoranjini David, Datturao Ramanand Mahesh, Uma Sambargi, Kademadkal Javaraiah Rashmi, Prabhavati Benakanal
Potentially malignant disorders (PMDs) of oral cavity and oral cancer remain a cause of serious concern despite intensive research and development. Diet and immunity have been identified to play a crucial role as modifying factors in these diseases. Our study intended to explore this relationship by estimating and comparing the serum levels of copper, iron and circulating immune complexes (CICs) in patients diagnosed with PMDs and oral cancer and normal healthy individuals. In this study, 40 histopathologically diagnosed cases of PMDs and oral cancer were included along with 30 healthy controls and 5 ml of venous blood was drawn using venipuncture...
October 10, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27721186/the-properties-and-utility-of-the-core-measure-of-melancholia
#17
REVIEW
Gordon Parker, Stacey McCraw
BACKGROUND: The CORE measure was designed to assess a central feature of melancholia - signs of psychomotor disturbance (PMD) - and so provide an alternate non-symptom based measure of melancholia or of its probability. This review evaluates development and application studies undertaken over the last 25 years to consider how well it has met its original objectives. METHODS: All studies published using the CORE measure as either the only or an adjunctive measure of melancholia were obtained and are considered in this review...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27709139/the-suppression-of-metastatic-lung-cancer-by-pulmonary-administration-of-polymer-nanoparticles-for-co-delivery-of-doxorubicin-and-survivin-sirna
#18
Caina Xu, Huayu Tian, Ping Wang, Yanbing Wang, Xuesi Chen
A pH-sensitive co-delivery system was designed for the treatment of metastatic lung cancers by pulmonary delivery of doxorubicin (DOX) and Survivin siRNA. Conjugates PEI-BMPH-DOX (PMD) of polyethylenimine (PEI) with DOX were developed via a pH-sensitive hydrazine bond (3-maleimidopropionic acid hydrazide, BMPH). Furthermore, the PMD/Survivin siRNA complex nanoparticles were prepared by electrostatic interaction between cationic PMD and anionic Survivin siRNA. The drug release of DOX from PMD conjugates increased with decreasing pH values...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27690653/thermal-injury-to-corticospinal-tracts-and-postoperative-motor-deficits-after-laser-interstitial-thermal-therapy
#19
Mayur Sharma, Ghaith Habboub, Mandana Behbahani, Danilo Silva, Gene H Barnett, Alireza M Mohammadi
OBJECTIVE Laser interstitial thermal therapy (LITT) has been increasingly used to treat deep-seated tumors. Despite its being minimally invasive, there is a risk of LITT damaging adjacent critical structures, including corticospinal tracts (CSTs). In this study, the authors investigated the predictive value of overlap between the hyperthermic field and CSTs in determining postoperative motor deficit (PMDs). METHODS More than 140 patients underwent an LITT procedure in our institution between April 2011 and June 2015...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27665271/nutritional-interventions-in-primary-mitochondrial-disorders-developing-an-evidence-base
#20
REVIEW
Kathryn M Camp, Danuta Krotoski, Melissa A Parisi, Katrina A Gwinn, Bruce H Cohen, Christine S Cox, Gregory M Enns, Marni J Falk, Amy C Goldstein, Rashmi Gopal-Srivastava, Gráinne S Gorman, Stephen P Hersh, Michio Hirano, Freddie Ann Hoffman, Amel Karaa, Erin L MacLeod, Robert McFarland, Charles Mohan, Andrew E Mulberg, Joanne C Odenkirchen, Sumit Parikh, Patricia J Rutherford, Shawne K Suggs-Anderson, W H Wilson Tang, Jerry Vockley, Lynne A Wolfe, Steven Yannicelli, Philip E Yeske, Paul M Coates
In December 2014, a workshop entitled "Nutritional Interventions in Primary Mitochondrial Disorders: Developing an Evidence Base" was convened at the NIH with the goals of exploring the use of nutritional interventions in primary mitochondrial disorders (PMD) and identifying knowledge gaps regarding their safety and efficacy; identifying research opportunities; and forging collaborations among researchers, clinicians, patient advocacy groups, and federal partners. Sponsors included the NIH, the Wellcome Trust, and the United Mitochondrial Diseases Foundation...
November 2016: Molecular Genetics and Metabolism
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