keyword
https://read.qxmd.com/read/38537152/ligand-field-sensitive-spin-acceleration-in-the-iron-catalyzed-2-2-cycloaddition-of-unactivated-alkenes-and-dienes
#1
JOURNAL ARTICLE
Hanna H Cramer, Coralie Duchemin, Carli B Kovel, Junho Kim, Matthew V Pecoraro, Paul J Chirik
Redox-active pyridine(diimine) (PDI) iron catalysts promote the reversible [2 + 2] cycloaddition of alkenes and dienes to cyclobutane derivatives that have applications ranging from fuels to chemically recyclable polymers. Metallacycles were identified as key intermediates, and spin crossover from the singlet to the triplet surface was calculated to facilitate the reductive coupling step responsible for the formation of the four-membered ring. In this work, a series of sterically and electronically differentiated PDI ligands was studied for the [2 + 2] cycloaddition of ethylene and butadiene to vinylcyclobutane...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38535577/-staphylococcus-capitis-central-line-associated-bloodstream-infections-in-the-neonatal-intensive-care-unit-a-single-center-four-year-experience-in-central-line-management-during-sepsis-treatment
#2
JOURNAL ARTICLE
Anna Sala, Valentina Pivetti, Alessandra Vittorini, Claudia Viggiano, Francesca Castoldi, Valentina Fabiano, Gianluca Lista, Francesco Cavigioli
Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). Staphylococcus capitis is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus...
March 7, 2024: Pathogens
https://read.qxmd.com/read/38535572/genetic-diversification-and-resistome-of-coagulase-negative-staphylococci-from-nostrils-of-healthy-dogs-and-dog-owners-in-la-rioja-spain
#3
JOURNAL ARTICLE
Idris Nasir Abdullahi, Carmen Lozano, Carmen González-Azcona, Myriam Zarazaga, Carmen Torres
Coagulase-negative staphylococci (CoNS) species in healthy dogs and their owners could be transferred between these hosts and carry diverse antimicrobial resistance (AMR) genes of public health concern. This study determined the frequency, diversity, and AMR genes of nasal CoNS from healthy dogs and in-contact people as well as the rate of intra-household (between healthy dogs and dog-owners) transmission of CoNS. Nasal samples were collected and processed from 34 dogs and 41 humans from 27 households, and CoNS identification was done by MALDI-TOF-MS...
March 5, 2024: Pathogens
https://read.qxmd.com/read/38535298/effects-of-different-feed-additives-on-intestinal-metabolite-composition-of-weaned-piglets
#4
JOURNAL ARTICLE
Mingxuan Zhao, Jian Zhang, Fuzhou Liu, Lv Luo, Mingbang Wei, Yourong Ye, Chamba Yangzom, Peng Shang
To study the effects of different feed additives on the weaning stress of Tibetan piglets, we selected 28 healthy, 30-day-old Tibetan weaned piglets and divided them into four groups, namely, the control group (basal feed without any antibiotic additions) (Nor), the group with the addition of the antibiotic lincomycin (Ant), the group with the addition of fifteen-flavor black pills of Tibetan medicine (Tib), and the group with the addition of fecal bacterial supernatant (Fec). We measured growth performance, blood physiological indexes, and metabolomics...
February 26, 2024: Metabolites
https://read.qxmd.com/read/38534682/in-vitro-microevolution-and-co-selection-assessment-of-amoxicillin-and-cefotaxime-impact-on-escherichia-coli-resistance-development
#5
JOURNAL ARTICLE
Ádám Kerek, Bence Török, Levente Laczkó, Zoltán Somogyi, Gábor Kardos, Krisztián Bányai, Eszter Kaszab, Krisztina Bali, Ákos Jerzsele
The global spread of antimicrobial resistance has become a prominent issue in both veterinary and public health in the 21st century. The extensive use of amoxicillin, a beta-lactam antibiotic, and consequent resistance development are particularly alarming in food-producing animals, with a focus on the swine and poultry sectors. Another beta-lactam, cefotaxime, is widely utilized in human medicine, where the escalating resistance to third- and fourth-generation cephalosporins is a major concern. The aim of this study was to simulate the development of phenotypic and genotypic resistance to beta-lactam antibiotics, focusing on amoxicillin and cefotaxime...
March 7, 2024: Antibiotics
https://read.qxmd.com/read/38534107/signaling-through-the-salmonella-pbga-lapb-regulatory-complex-activates-lpxc-proteolysis-and-limits-lipopolysaccharide-biogenesis-during-stationary-phase-growth
#6
JOURNAL ARTICLE
Joshua A Mettlach, Melina B Cian, Medha Chakraborty, Zachary D Dalebroux
Salmonella enterica serovar Typhimurium ( S . Typhimurium) controls lipopolysaccharide (LPS) biosynthesis by regulating proteolysis of LpxC, the rate-limiting enzyme and target of preclinical antibiotics. PbgA/YejM/LapC regulates LpxC levels and controls outer membrane (OM) LPS composition at the log-to-stationary phase transition. Suppressor substitutions in <u>L</u>PS <u>a</u>ssembly <u>p</u>rotein <u>B</u> (LapB/YciM) rescue the LPS and OM integrity defects of pbgA -mutant S ...
March 27, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38533010/vacancy-induced-enhanced-photocatalytic-activity-of-nitrogen-doped-cuo-nps-synthesized-by-co-precipitation-method
#7
JOURNAL ARTICLE
Md Jannatul Ferdous Anik, Samiya Rahman Mim, Syed Sammo Swapno, Sirajum Munira, Oishy Roy, Md Muktadir Billah
The chemical co-precipitation method, an effective approach in the synthesis of nanomaterials, was used to synthesize CuO nanoparticles (NPs). Structural and morphological modification of undoped and nitrogen (N) doped CuO nanoparticles were studied thoroughly using X-ray diffraction (XRD), FT-IR and field emission scanning electron microscope (FE SEM). Doping effect on defects was investigated using X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and photoluminescence (PL) spectroscopy. Thus, the effect of doping on crystallinity, crystallite size, strain induced in lattice, defects and electron-hole recombination rate were investigated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532808/large-scale-pan-genomic-analysis-of-mycobacterium-tuberculosis-reveals-key-insights-into-molecular-evolutionary-rate-of-specific-processes-and-functions
#8
JOURNAL ARTICLE
Eshan Bundhoo, Anisah W Ghoorah, Yasmina Jaufeerally-Fakim
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), an infectious disease that is a major killer worldwide. Due to selection pressure caused by the use of antibacterial drugs, Mtb is characterised by mutational events that have given rise to multi drug resistant (MDR) and extensively drug resistant (XDR) phenotypes. The rate at which mutations occur is an important factor in the study of molecular evolution, and it helps understand gene evolution. Within the same species, different protein-coding genes evolve at different rates...
2024: Evolutionary Bioinformatics Online
https://read.qxmd.com/read/38531669/h3k4me1-recruits-dna-repair-proteins-in-plants
#9
JOURNAL ARTICLE
Daniela Quiroz, Satoyo Oya, Diego Lopez-Mateos, Kehan Zhao, Alice Pierce, Lissandro Ortega, Alissza Ali, Pablo Carbonell-Bejerano, Vladimir Yarov-Yarovoy, Sae Suzuki, Gosuke Hayashi, Akihisa Osakabe, J Grey Monroe
DNA repair proteins can be recruited by their histone reader domains to specific epigenomic features, with consequences on intragenomic mutation rate variation. Here, we investigated H3K4me1-associated hypomutation in plants. We first examined two proteins which, in plants, contain Tudor histone reader domains: PRECOCIOUS DISSOCIATION OF SISTERS 5 (PDS5C), involved in homology-directed repair, and MUTS HOMOLOG 6 (MSH6), a mismatch repair protein. The MSH6 Tudor domain of Arabidopsis (Arabidopsis thaliana) binds to H3K4me1 as previously demonstrated for PDS5C, which localizes to H3K4me1-rich gene bodies and essential genes...
March 26, 2024: Plant Cell
https://read.qxmd.com/read/38530999/the-influence-of-habitual-physical-activity-and-sedentary-behavior-on-objective-and-subjective-hot-flashes-at-midlife
#10
JOURNAL ARTICLE
Sarah Witkowski, Quinn White, Sofiya Shreyer, Daniel E Brown, Lynnette Leidy Sievert
OBJECTIVE: The purpose of this study was to evaluate relationships between physical activity, sedentary time, and hot flashes during both waking and sleeping periods using concurrent objective and subjective measures of hot flashes in midlife women. METHODS: Women aged 45 to 55 years (n = 196) provided self-reported data on physical activity and underwent 24 hours of hot flash monitoring using sternal skin conductance. Participants used event marking and logs to indicate when hot flashes were perceived...
March 25, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38530769/ba-3-snga-10-x-in-x-o-20-0-%C3%A2-x-%C3%A2-2-site-selective-doping-band-structure-engineering-and-photocatalytic-overall-water-splitting
#11
JOURNAL ARTICLE
Weihua Li, Guangxiang Lu, Yanhong Ding, Rihong Cong, Tao Yang
Developing new photocatalysts and deciphering the structure-property relationship are always the central topics in photocatalysis. In this study, a new photocatalyst Ba3 SnGa10 O20 containing two d10 metal cations was prepared by a high temperature solid state reaction, and its crystal structure was investigated by Rietveld refinements of monochromatic X-ray powder diffraction data for the first time. There are 2 Ba, 4 metal cations and 6 O independent atoms in a unit cell. Sn4+ and Ga3+ co-occupy the octahedral cavities named M1 and M2 sites, and the other two metal sites are fully occupied by Ga3+ ...
March 26, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38529929/auto-phylo-v2-and-auto-phylo-pipeliner-building-advanced-flexible-and-reusable-pipelines-for-phylogenetic-inferences-estimation-of-variability-levels-and-identification-of-positively-selected-amino-acid-sites
#12
JOURNAL ARTICLE
Hugo López-Fernández, Miguel Pinto, Cristina P Vieira, Pedro Duque, Miguel Reboiro-Jato, Jorge Vieira
The vast amount of genome sequence data that is available, and that is predicted to drastically increase in the near future, can only be efficiently dealt with by building automated pipelines. Indeed, the Earth Biogenome Project will produce high-quality reference genome sequences for all 1.8 million named living eukaryote species, providing unprecedented insight into the evolution of genes and gene families, and thus on biological issues. Here, new modules for gene annotation, further BLAST search algorithms, further multiple sequence alignment methods, the adding of reference sequences, further tree rooting methods, the estimation of rates of synonymous and nonsynonymous substitutions, and the identification of positively selected amino acid sites, have been added to auto-phylo (version 2), a recently developed software to address biological problems using phylogenetic inferences...
March 27, 2024: Journal of Integrative Bioinformatics
https://read.qxmd.com/read/38527577/autonomic-neuronal-modulations-in-cardiac-arrhythmias-current-concepts-and-emerging-therapies
#13
REVIEW
Ravina Rai, Virendra Singh, Zaved Ahmad, Abhishek Jain, Deepali Jat, Siddhartha Kumar Mishra
The pathophysiology of atrial fibrillation and ventricular tachycardia that result in cardiac arrhythmias is related to the sustained complicated mechanisms of the autonomic nervous system. Atrial fibrillation is when the heart beats irregularly, and ventricular arrhythmias are rapid and inconsistent heart rhythms, which involves many factors including the autonomic nervous system. It's a complex topic that requires careful exploration. Cultivation of speculative knowledge on atrial fibrillation; the irregular rhythm of the heart and ventricular arrhythmias; rapid oscillating waves resulting from mistakenly inconsistent P waves, and the inclusion of an autonomic nervous system is an inconceivable approach toward clinical intricacies...
March 23, 2024: Physiology & Behavior
https://read.qxmd.com/read/38526391/potential-risks-and-benefits-of-desiccated-thyroid-extract-for-the-treatment-of-hypothyroidism-a-systematic-review
#14
JOURNAL ARTICLE
Kamilla Ryom Riis, Camilla Bøgelund Larsen, Steen Joop Bonnema
BACKGROUND: Desiccated thyroid extract (DTE) is no longer recommended for treatment of hypothyroidism but is still in use. This review aimed to summarize the available literature on treatment with DTE in adult hypothyroid patients. METHODS: The search was conducted up until the 6th of January 2024 in six electronic databases. Two reviewers independently screened all search results. The retrieved studies compared DTE treatment with levothyroxine or combination therapy with liothyronine and levothyroxine...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38525761/the-prevalence-risk-factors-and-antimicrobial-resistance-determinants-of-helicobacter-pylori-detected-in-dyspeptic-patients-in-north-central-bangladesh
#15
JOURNAL ARTICLE
Syeda Jannatul Ferdaus, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Nazia Haque, Mohammad Sadekuzzaman, Mohammad Reazul Karim, Syed Mahmudul Islam, Abdullah Al Mamun, Fardousi Akter Sathi, Proma Basak, Rifat Binte Nahid, Suraiya Aktar, Nobumichi Kobayashi
Chronic infection of Helicobacter pylori represents a key factor in the etiology of gastrointestinal diseases, with high endemicity in South Asia. The present study aimed to determine the prevalence of H. pylori among dyspeptic patients in north-central Bangladesh (Mymensingh) and analyze risk factors of infection and antimicrobial resistance (AMR) determinants in the pathogen. Endoscopic gastrointestinal biopsy samples were collected from dyspeptic patients for a one-year period from March 2022 and were checked for the presence of H...
February 22, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38525695/effects-of-acute-and-developmental-exposure-to-bisphenol-s-on-chinese-medaka-oryzias-sinensis
#16
JOURNAL ARTICLE
Bingying Li, Yongsi Huang, Duan Pi, Xiang Li, Yafen Guo, Zhiying Liang, Xiaohong Song, Junjie Wang, Xuegeng Wang
Bisphenol S (BPS), one of the substitutes for bisphenol A (BPA), is widely used in various commodities. The BPS concentrations in surface water have gradually increased in recent years, making it a predominant bisphenol analogue in the aquatic environment and raising concerns about its health and ecological effects on aquatic organisms. For this study, we conducted a 96 h acute toxicity test and a 15-day developmental exposure test to assess the adverse effects of BPS exposure in Chinese medaka ( Oryzias sinensis ), a new local aquatic animal model...
March 22, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38522658/elements-of-the-c-terminal-tail-of-a-c-terminal-domain-homolog-of-the-orange-carotenoid-protein-determining-xanthophyll-uptake-from-liposomes
#17
JOURNAL ARTICLE
Kristina Likkei, Marcus Moldenhauer, Neslihan N Tavraz, Nikita A Egorkin, Yury B Slonimskiy, Eugene G Maksimov, Nikolai N Sluchanko, Thomas Friedrich
Carotenoids perform multifaceted roles in life ranging from coloration over light harvesting to photoprotection. The Orange Carotenoid Protein (OCP), a light-driven photoswitch involved in cyanobacterial photoprotection, accommodates a ketocarotenoid vital for its function. OCP extracts its ketocarotenoid directly from membranes, or accepts it from homologs of its C-terminal domain (CTDH). The CTDH from Anabaena (AnaCTDH) was shown to be important for carotenoid transfer and delivery from/to membranes. The C-terminal tail of AnaCTDH is a critical structural element likely serving as a gatekeeper and facilitator of carotenoid uptake from membranes...
March 22, 2024: Biochimica et Biophysica Acta. Bioenergetics
https://read.qxmd.com/read/38522603/pesticide-risk-assessment-in-european-agriculture-distribution-patterns-ban-substitution-effects-and-regulatory-implications
#18
JOURNAL ARTICLE
Luisa Gensch, Kerstin Jantke, Livia Rasche, Uwe A Schneider
This study estimates the risks of agricultural pesticides on non-target organisms and the environment by combining detailed pesticide application data for 2015 with the Danish risk indicator Pesticide Load. We quantify and map the pesticide load of 59 pesticides on 28 crops and pastures in the EU. Furthermore, we investigate how recent bans on 14 pesticides in the EU could reduce pesticide use and load. Key findings show that the highest pesticide loads per hectare occur in Cyprus and the Netherlands due to high application rates and a high proportion of vegetable production...
March 22, 2024: Environmental Pollution
https://read.qxmd.com/read/38521294/ross-procedure-valve-function-clinical-outcomes-and-predictors-after-25-years-follow-up
#19
REVIEW
Laura Pardo González, Martín Ruiz-Ortiz, Mónica Delgado, Sara Rodriguez, Rafael Villalba, Carlos Merino, Jaime Casares, Dolores Mesa, José Suarez de Lezo, Manuel Pan
The following letter presents an answer of a comment of our work titled "Ross procedure: valve function, clinical outcomes and predictors after 25 years' follow-up," recently published in your journal by Rangwala et al1 . As our colleagues point out, the Ross procedure has excellent survival rates but a significant risk of valve dysfunction and therefore reintervention at follow-up. Although the survival advantage with the Ross procedure appears to be consistent compared with mechanical valve substitutes, this benefit is not as clear compared with biological valve substitutes...
March 21, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38518848/substitution-of-dietary-monounsaturated-fatty-acids-from-olive-oil-for-saturated-fatty-acids-from-lard-increases-ldl-apolipoprotein-b-100-fractional-catabolic-rate-in-subjects-with-dyslipidemia-associated-with-insulin-resistance-a-randomized-controlled-trial
#20
JOURNAL ARTICLE
Louis-Charles Desjardins, Francis Brière, André J Tremblay, Maryka Rancourt-Bouchard, Jean-Philippe Drouin-Chartier, Jacques Corbeil, Valéry Lemelin, Amélie Charest, Ernst J Schaefer, Benoît Lamarche, Patrick Couture
BACKGROUND: The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown. OBJECTIVE: This study aimed to evaluate the impact of substituting MUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo)B-containing lipoproteins and on the plasma lipidomic profile in adults with IR-induced dyslipidemia...
March 20, 2024: American Journal of Clinical Nutrition
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