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https://www.readbyqxmd.com/read/28231347/histomorphometric-results-after-postextraction-socket-healing-with-different-biomaterials-a-systematic-review-of-the-literature-and-meta-analysis
#1
Stefano Corbella, Silvio Taschieri, Luca Francetti, Roberto Weinstein, Massimo Del Fabbro
PURPOSE: The aim of this systematic review was to investigate which material is the most effective bone substitute for alveolar bone healing by evaluating histomorphometric outcomes after healing of postextraction sockets in humans. MATERIALS AND METHODS: A manual and electronic search (PubMed, EMBASE, Cochrane Library) was performed using a search string prepared ad hoc. Data were statistically analyzed by calculating weighted mean percentage of new bone formation (primary outcome) and weighted mean percentage of residual biomaterial, soft/connective tissue, and nonmineralized tissue (secondary outcomes) in the biopsies...
February 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28231082/rheometric-non-isothermal-gelatinization-kinetics-of-chickpea-flour-based-gluten-free-muf%C3%AF-n-batters-with-added-biopolymers
#2
María Dolores Alvarez, Francisco Javier Cuesta, Beatriz Herranz, Wenceslao Canet
An attempt was made to analyze the elastic modulus (G0) of chickpea flour (CF)-based muffin batters made with CF alone and with added biopolymers (whey protein (WP), xanthan gum (XG), inulin (INL), and their blends) in order to evaluate their suitability to be a wheat flour (WF) substitute in muffins, and to model the heat-induced gelatinization of batters under non-isothermal heating condition from 25 ◦C to 90 ◦C. A rheological approach is proposed to determine the kinetic parameters (reaction order (n), frequency factor (k0), and activation energy (Ea)) using linearly-increasing temperature...
January 2, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230776/effects-and-side-effects-of-using-sorafenib-and-sunitinib-in-the-treatment-of-metastatic-renal-cell-carcinoma
#3
REVIEW
Caroline Randrup Hansen, Daniela Grimm, Johann Bauer, Markus Wehland, Nils E Magnusson
In recent years, targeted therapies have proven beneficial in terms of progression-free survival (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC). The tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib are included in international clinical guidelines as first-line and second-line therapy in mRCC. Hypertension is an adverse effect of these drugs and the degree of hypertension associates with the anti-tumour effect. Studies have compared newer targeted drugs to sorafenib and sunitinib in terms of PFS, OS, quality of life and safety profiles...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230284/formation-of-%C3%AE-lactones-with-anti-baeyer-villiger-regiochemistry-investigations-into-the-mechanism-of-the-cerium-catalyzed-aerobic-coupling-of-%C3%AE-oxoesters-with-enol-acetates
#4
Jens Christoffers, Irina Geibel, Anna Dierks, Thomas Müller
The cerium-catalyzed, aerobic coupling of β-oxoesters with enol acetates and dioxygen yields δ-lactones with a 1,4-diketone moiety. In contrast to the Baeyer-Villiger oxidation (BVO), where the higher substituted residue migrates, in this case of an oxidative C-C coupling reaction the less substituted alkyl residue undergoes a 1,2-shift. An endoperoxidic oxycarbenium ion comparable to the Criegee intermediate in the BVO is proposed as a reaction intermediate and submitted to conformational analysis by computational methods...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28229476/initial-medication-non-adherence-prevalence-and-predictive-factors-in-a-cohort-of-1-6-million-primary-care-patients
#5
I Aznar-Lou, A Fernández, M Gil-Girbau, M Fajó-Pascual, P Moreno-Peral, M T Peñarrubia-Maria, A Serrano-Blanco, A Sánchez-Niubó, M March-Pujol, A M Jové, M Rubio-Valera
INTRODUCTION: Adherence to medicines is vital in treating diseases. Initial medication non-adherence (IMNA) - defined as not obtaining a medication the first time it is prescribed - has been poorly explored. Previous studies show IMNA rates between 6 and 28% in Primary Care (PC). The aims of this study were to determine prevalence and predictive factors of IMNA in the most prescribed and expensive pharmacotherapeutic groups in the Catalan health system. METHODS: Retrospective, register-based cohort study which linked Catalan PC System (Spain) prescription and invoicing databases...
February 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28229145/oxidation-potentials-of-phenols-and-anilines-correlation-analysis-of-electrochemical-and-theoretical-values
#6
Ania S Pavitt, Eric J Bylaska, Paul G Tratnyek
Phenols and anilines have been studied extensively as reductants of environmental oxidants (such as manganese dioxide) and as reductates (e.g., model contaminants) that are transformed by environmental oxidants (ozone, triple organic matter, etc.). The thermodynamics and kinetics of these reactions have been interpreted using oxidation potentials for substituted phenols and anilines, often using a legacy experimental dataset that is of uncertain quality. Although there are many alternative oxidation potential data, there has been little systematic analysis of the relevance, reliability, and consistency of the data obtained by different methods...
February 23, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28228231/evaluating-community-pharmacists-perspectives-and-practices-concerning-generic-medicines-substitution-in-saudi-arabia-a-cross-sectional-study
#7
Fahad S Alkhuzaee, Hamdan M Almalki, Ammar Y Attar, Shoeab I Althubiani, Wassam Ali Almuallim, Ejaz Cheema, Muhammad Abdul Hadi
OBJECTIVES: To assess the community pharmacists' knowledge, attitude, perception and current practices towards generic medicines substitution in Saudi Arabia. METHODS: A cross-sectional study was conducted between February and March 2016 in the Makkah region, Saudi Arabia. A 25-item, structured, validated, pilot-tested and self-completed questionnaire was used to achieve study objectives. A 4-step systematic sampling technique was used to recruit community pharmacists...
December 2016: Health Policy
https://www.readbyqxmd.com/read/28225773/whole-genome-duplication-and-molecular-evolution-in-cornus-l-cornaceae-insights-from-transcriptome-sequences
#8
Yan Yu, Qiuyun Xiang, Paul S Manos, Douglas E Soltis, Pamela S Soltis, Bao-Hua Song, Shifeng Cheng, Xin Liu, Gane Wong
The pattern and rate of genome evolution have profound consequences in organismal evolution. Whole-genome duplication (WGD), or polyploidy, has been recognized as an important evolutionary mechanism of plant diversification. However, in non-model plants the molecular signals of genome duplications have remained largely unexplored. High-throughput transcriptome data from next-generation sequencing have set the stage for novel investigations of genome evolution using new bioinformatic and methodological tools in a phylogenetic framework...
2017: PloS One
https://www.readbyqxmd.com/read/28225619/charge-transfer-induced-para-selective-sp2-c-h-bond-activation-of-arenes-by-use-of-a-hypervalent-iodine-compound-a-theoretical-study
#9
Jiyang Zhao, Shuhua Li
The reaction mechanism of the C-H bond activation of toluene promoted by the hypervalent iodine compound TIPP-I(OH)OTs was investigated in detail by density functional theory calculations. Our calculations show that a plausible reaction pathway of the C-H bond activation of toluene contains two stages: (1) the ligand exchange process on TIPP-I(OH)OTs, involving the substitution of the hydroxyl group and tosyloxyl group with TfOH; (2) the C-H bond activation of toluene promoted by the hypervalent iodine center with the assistance of the triflate anion...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28225601/rational-optimization-of-diphenyl-ether-binding-kinetics-to-the-enoyl-acp-reductase-fabi1-from-burkholderia-pseudomallei
#10
Carla Maya Neckles, Sandra Eltschkner, Jason Ellsworth Cummings, Maria Hirschbeck, Fereidoon Daryaee, Gopal R Bommineni, Zhuo Zhang, Lauren A Spagnuolo, Weixuan Yu, Shabnam Davoodi, Richard A Slayden, Caroline Kisker, Peter J Tonge
There is growing awareness of the link between drug-target residence time and in vivo drug activity, and there are increasing efforts to determine the molecular factors that control the lifetime of a drug-target complex. Rational alterations in drug-target residence time require knowledge of both the ground and transition states on the inhibition reaction coordinate, and we have determined the structure-kinetic relationship for 22 ethyl or hexyl substituted diphenyl ethers that are slow-binding inhibitors of bpFabI1, the enoyl-ACP reductase FabI1 from Burkholderia pseudomallei...
February 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28224500/automated-estimation-of-mouse-social-behaviors-based-on-a-hidden-markov-model
#11
Toshiya Arakawa, Akira Tanave, Aki Takahashi, Satoshi Kakihara, Tsuyoshi Koide, Takashi Tsuchiya
Recent innovations in sensing and Information and Communication Technology (ICT) have enabled researchers in animal behavior to collect an enormous amount of data. Consequently, the development of an automated system to substitute for some of the observations and analyses that are performed currently by expert researchers is becoming a crucial issue so that the vast amount of accumulated data can be processed efficiently. For this purpose, we introduce a process for the automated classification of the social interactive status of two mice in a square field on the basis of a Hidden Markov model (HMM)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28224003/darwinism-for-the-genomic-age-connecting-mutation-to-diversification
#12
Xia Hua, Lindell Bromham
A growing body of evidence suggests that rates of diversification of biological lineages are correlated with differences in genome-wide mutation rate. Given that most research into differential patterns of diversification rate have focused on species traits or ecological parameters, a connection to the biochemical processes of genome change is an unexpected observation. While the empirical evidence for a significant association between mutation rate and diversification rate is mounting, there has been less effort in explaining the factors that mediate this connection between genetic change and species richness...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28223393/novel-bacterial-topoisomerase-inhibitors-with-potent-broad-spectrum-activity-against-drug-resistant-bacteria
#13
Cédric Charrier, Anne-Marie Salisbury, Victoria J Savage, Thomas Duffy, Emmanuel Moyo, Nathan Chaffer-Malam, Nicola Ooi, Rebecca Newman, Jonathan Cheung, Richard Metzger, David McGarry, Mark Pichowicz, Ralph Sigerson, Ian R Cooper, Gary Nelson, Hayley S Butler, Mark Craighead, Andrew J Ratcliffe, Stuart A Best, Neil R Stokes
The Novel Bacterial Topoisomerase Inhibitor class is an investigational type of antibacterial inhibitor of DNA gyrase and topoisomerase IV that do not have cross-resistance with the quinolones. Here, we report the evaluation of the in vitro properties of a new series of this type of small molecules. Exemplar compounds selectively and potently inhibited the catalytic activities of Escherichia coli DNA gyrase and topoisomerase IV but did not block the DNA breakage-reunion step. Compounds showed broad-spectrum inhibitory activity against a wide range of Gram-positive and Gram-negative pathogens, including biodefence microorganisms, and Mycobacterium tuberculosis No cross-resistance with quinolone-resistant Staphylococcus aureus and E...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28222679/comparative-mitogenomics-indicates-respiratory-competence-in%C3%A2-parasitic-viscum-despite%C3%A2-loss-of-complex-i%C3%A2-and-extreme-sequence%C3%A2-divergence-and-reveals-horizontal-gene-transfer-and-remarkable%C3%A2-variation-in-genome-size
#14
Elizabeth Skippington, Todd J Barkman, Danny W Rice, Jeffrey D Palmer
BACKGROUND: Aerobically respiring eukaryotes usually contain four respiratory-chain complexes (complexes I-IV) and an ATP synthase (complex V). In several lineages of aerobic microbial eukaryotes, complex I has been lost, with an alternative, nuclear-encoded NADH dehydrogenase shown in certain cases to bypass complex I and oxidize NADH without proton translocation. The first loss of complex I in any multicellular eukaryote was recently reported in two studies; one sequenced the complete mitogenome of the hemiparasitic aerial mistletoe, Viscum scurruloideum, and the other sequenced the V...
February 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28221706/4-5-dimethyl-2-iodoxybenzenesulfonic-acid-catalyzed-site-selective-oxidation-of-2-substituted-phenols-to-1-2-quinols
#15
Muhammet Uyanik, Tatsuya Mutsuga, Kazuaki Ishihara
A site-selective hydroxylative dearomatization of 2-substituted phenols to either 1,2-benzoquinols or their cyclodimers, catalyzed by 4,5-dimethyl-2-iodoxybenzenesulfonic acid with Oxone, has been developed. Natural products such as biscarvacrol and lacinilene C methyl ether could be synthesized efficiently under mild reaction conditions. Furthermore, both the reaction rate and site selectivity could be further improved by the introduction of a trialkylsilylmethyl substituent at the 2-position of phenols...
February 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28221250/factors-associated-with-discontinuation-of-anti-tnf-inhibitors-among-persons-with-ibd-a-population-based-analysis
#16
Laura E Targownik, Aruni Tennakoon, Stella Leung, Lisa M Lix, Zoann Nugent, Harminder Singh, Charles N Bernstein
INTRODUCTION: Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation of anti-TNF therapy is a marker of lack of effectiveness, intolerance, and patient/physician practice preferences. METHODS: We identified all persons with IBD in Manitoba who were dispensed infliximab (IFX) and adalimumab (ADA) between 2001 and 2014...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28221147/-update-in-the-management-of-ureteral-lithiasis-semirigid-and-flexible-ureterorenoscopy
#17
Carlos Torrecilla Ortiz, Sergi Colom Feixas
OBJECTIVE: The contribution of therapeutic ureteroscopy done by Perez Castro in 1980 varied the management algorithm for ureteral lithiasis worldwide. The techniques of Retrograde Ureteroscopy and transrenal antegrade ureteroscopy led to the abandonment of open surgery for the treatment of ureteral lithiasis. Only Shock wave lithotripsy has maintained similar success rates in selected cases. METHODS: Descriptive analysis of the semirigid and flexible ureteroscopy techniques performed in our department over the last 10 years giving detail on the technique and safety tips to increase the efficacy and efficiency of ureteroscopy...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28221047/excited-state-proton-transfer-in-indigo
#18
Joao Pina, Daniela Santos Sarmento, Marco Accoto, Pier Luigi Gentili, Luigi Vaccaro, Adelino M Galvão, J Sérgio Seixas de Melo
Excited state proton transfer (ESPT) in Indigo (Ind) and its mono hexyl-substituted derivative (NHxInd) in solution was investigated experimentally as a function of solvent viscosity, polarity and temperature, and theoretically by time-dependent DFT (TDDFT) calculations. Although a single emission band is observed, the fluorescence decays (collected at different wavelengths along the emission band using time-correlated single photon counting (TCSPC)) are bi-exponential, with two identical decay times but different pre-exponential factors, consistent with the existence of excited state keto and enol species...
February 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28220915/modulation-of-the-co2-fixation-in-dinickel-azacryptands
#19
F Möller, L Castañeda-Losada, J R C Junqueira, R G Miller, M L Reback, B Mallick, M van Gastel, U-P Apfel
While bimetallic azacryptands are known to selectively coordinate CO2, there is little knowledge on how different substitution patterns of the azacryptand cage structure influence CO2 coordination. Stopped-flow UV-vis spectroscopy, electrochemical analysis and DFT calculations were performed on a series of dinickel azacryptands and showed different rates of CO2 coordination to the complexes. We herein present data showing that the different flexibility of the azacryptands is directly responsible for the difference in the CO2 uptake capability of dinickel azacryptand complexes...
February 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28220653/systematic-review-of-the-oncological-and-functional-outcomes-of-pelvic-organ-preserving-cystectomy-compared-with-standard-radical-cystectomy-in-women-who-undergo-curative-surgery-and-orthotopic-neobladder-substitution-for-bladder-cancer
#20
REVIEW
Erik Veskimäe, Yann Neuzillet, Mathieu Rouanne, Steven MacLennan, Thomas B L Lam, Yuhong Yuan, Eva Compérat, Nigel C Cowan, Georgios Gakis, Antoine G van der Heijden, Maria J Ribal, J Alfred Witjes, Thierry Lebrét
CONTEXT: Pelvic-organ preserving radical cystectomy (POPRC) for female patients may improve postoperative sexual and urinary functions without compromising the oncological outcome compared with standard radical cystectomy (RC). OBJECTIVE: To determine the effect of POPRC on sexual, oncological and urinary outcomes compared with RC in women who undergo standard curative surgery and orthotopic neobladder substitution for bladder cancer (BCa). EVIDENCE ACQUISITION: Medline, Embase, Cochrane controlled trials databases and clinicaltrial...
February 20, 2017: BJU International
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