Daniela Quiroz, Satoyo Oya, Diego Lopez-Mateos, Kehan Zhao, Alice Pierce, Lissandro Ortega, Alissza Ali, Pablo Carbonell-Bejerano, Vladimir Yarov-Yarovoy, Sae Suzuki, Gosuke Hayashi, Akihisa Osakabe, J Grey Monroe
DNA repair proteins can be recruited by their histone reader domains to specific epigenomic features, with consequences on intragenomic mutation rate variation. Here, we investigated H3K4me1-associated hypomutation in plants. We first examined two proteins which, in plants, contain Tudor histone reader domains: PRECOCIOUS DISSOCIATION OF SISTERS 5 (PDS5C), involved in homology-directed repair, and MUTS HOMOLOG 6 (MSH6), a mismatch repair protein. The MSH6 Tudor domain of Arabidopsis (Arabidopsis thaliana) binds to H3K4me1 as previously demonstrated for PDS5C, which localizes to H3K4me1-rich gene bodies and essential genes...
March 26, 2024: Plant Cell