Chuyu Pan, Shiqiang Cheng, Li Liu, Yujing Chen, Peilin Meng, Xuena Yang, Chun'e Li, Jingxi Zhang, Zhen Zhang, Huijie Zhang, Bolun Cheng, Yan Wen, Yumeng Jia, Feng Zhang
BACKGROUND: Rare variants are believed to play a substantial role in the genetic architecture of mental disorders, particularly in coding regions. However, limited evidence supports the impact of rare variants on anxiety. METHODS: Using whole-exome sequencing data from 200,643 participants in the UK Biobank, we investigated the contribution of rare variants to anxiety. Firstly, we computed genetic risk score (GRS) of anxiety utilizing genotype data and summary data from a genome-wide association study (GWAS) on anxiety disorder...
December 26, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry